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cancer</title> <meta name="description" content="Search results for: testicular cancer"> <meta name="keywords" content="testicular cancer"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="testicular cancer"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2167</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: testicular cancer</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2167</span> Early Metastatic Cancer: A Review of Its Management and Outcomes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Diwei%20Lin">Diwei Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Amanda%20Jia%20Hui%20Tan"> Amanda Jia Hui Tan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In 2012, testicular cancer was estimated to account for 940 disability adjusted life years in Australia; of these, 450 were years lost due to premature death and 500 were years of healthy life lost due to disease, disability or injury. Testicular choriocarcinoma is one of the rarest variants of testicular germ cell tumours, accounting for less than 1% of testicular germ cell tumours and only about 0.19% of all testicular tumours. Management involves radical orchiectomy followed by chemotherapy. Even then, the prognosis is extremely poor. This case report describes a 20-year-old male with pure testicular choriocarcinoma with pulmonary metastases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=testicular%20cancer" title="testicular cancer">testicular cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=choriocarcinoma" title=" choriocarcinoma"> choriocarcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=cryptorchidism" title=" cryptorchidism"> cryptorchidism</a>, <a href="https://publications.waset.org/abstracts/search?q=chemotherapy" title=" chemotherapy"> chemotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=metastatic%20testicular%20cancer" title=" metastatic testicular cancer"> metastatic testicular cancer</a> </p> <a href="https://publications.waset.org/abstracts/11056/early-metastatic-cancer-a-review-of-its-management-and-outcomes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/11056.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">363</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2166</span> Involvement of Multi-Drug Resistance Protein (Mrp) 3 in Resveratrol Protection against Methotrexate-Induced Testicular Damage</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20A.%20Morsy">Mohamed A. Morsy</a>, <a href="https://publications.waset.org/abstracts/search?q=Azza%20A.%20K.%20El-Sheikh"> Azza A. K. El-Sheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdulla%20Y.%20Al-Taher"> Abdulla Y. Al-Taher</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of the present study is to investigate the effect of resveratrol (RES) on methotrexate (MTX)-induced testicular damage. RES (10 mg/kg/day) was given for 8 days orally and MTX (20 mg/kg i.p.) was given at day 4 of experiment, with or without RES in rats. MTX decreased serum testosterone, induced histopathological testicular damage, increased testicular tumor necrosis factor-α level and expression of nuclear factor-κB and cyclooxygenase-2. In MTX/RES group, significant reversal of these parameters was noticed, compared to MTX group. Testicular expression of multidrug resistance protein (Mrp) 3 was three- and five-folds higher in RES- and MTX/RES-treated groups, respectively. In vitro, using prostate cancer cells, each of MTX and RES alone induced cytotoxicity with IC50 0.18 ± 0.08 and 20.5 ± 3.6 µM, respectively. RES also significantly enhanced cytotoxicity of MTX. In conclusion, RES appears to have dual beneficial effect, as it promotes MTX tumor cytotoxicity, while protecting the testes, probably via up-regulation of testicular Mrp3 as a novel mechanism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=resveratrol" title="resveratrol">resveratrol</a>, <a href="https://publications.waset.org/abstracts/search?q=methotrexate" title=" methotrexate"> methotrexate</a>, <a href="https://publications.waset.org/abstracts/search?q=multidrug%20resistance%20protein%203" title=" multidrug resistance protein 3"> multidrug resistance protein 3</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20necrosis%20factor-%CE%B1" title=" tumor necrosis factor-α"> tumor necrosis factor-α</a>, <a href="https://publications.waset.org/abstracts/search?q=nuclear%20factor-%CE%BAB" title=" nuclear factor-κB"> nuclear factor-κB</a>, <a href="https://publications.waset.org/abstracts/search?q=cyclooxygenase-2" title=" cyclooxygenase-2"> cyclooxygenase-2</a> </p> <a href="https://publications.waset.org/abstracts/17378/involvement-of-multi-drug-resistance-protein-mrp-3-in-resveratrol-protection-against-methotrexate-induced-testicular-damage" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17378.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">454</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2165</span> Anomalous Origin of Bilateral Testicular Arteries: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arthi%20Ganapathy">Arthi Ganapathy</a>, <a href="https://publications.waset.org/abstracts/search?q=Arithra%20Banerjee"> Arithra Banerjee</a>, <a href="https://publications.waset.org/abstracts/search?q=Saroj%20Kaler"> Saroj Kaler</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Abdominal aorta is the sole purveyor of all organs in the abdomen. Anomalies of its main trunk or its branches are to be meticulously observed as it effects the perfusion of an organ. Varying patterns of the testicular artery is one of them. The origin and course of testicular arteries have to be identified carefully during various surgical procedures like renal transplant, intra abdominal surgeries and even in orthopedic surgery like spine surgery. With the advent of new intra-abdominal therapeutic and diagnostic techniques, the anatomy of testicular arteries has assumed much more significance. Though the variations of the testicular vein are well documented, the variations of the testicular artery are not so frequent in incidence. We report a case of the bilateral aberrant origin of the testicular artery from polar renal arteries. We also discuss its developmental basis. Such anomalies if left unnoticed will lead to serious intraoperative complications during procedures on retroperitoneal organs. Any damage to testicular arteries will compromise the function of the gonads. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cadaver" title="cadaver">cadaver</a>, <a href="https://publications.waset.org/abstracts/search?q=gonadal" title=" gonadal"> gonadal</a>, <a href="https://publications.waset.org/abstracts/search?q=renal" title=" renal"> renal</a>, <a href="https://publications.waset.org/abstracts/search?q=surgery" title=" surgery"> surgery</a> </p> <a href="https://publications.waset.org/abstracts/77926/anomalous-origin-of-bilateral-testicular-arteries-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77926.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">225</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2164</span> Protective Effect of Thymoquinone against Arsenic-Induced Testicular Toxicity in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amr%20A.%20Fouad">Amr A. Fouad</a>, <a href="https://publications.waset.org/abstracts/search?q=Waleed%20H.%20Albuali"> Waleed H. Albuali</a>, <a href="https://publications.waset.org/abstracts/search?q=Iyad%20Jresat"> Iyad Jresat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The protective effect of thymoquinone (TQ) was investigated in rats exposed to testicular injury induced by sodium arsenite (10mg/kg/day, orally, for two days). TQ treatment (10mg/kg/day, intraperitoneal injection) was applied for five days, starting three day before arsenic administration. TQ significantly attenuated the arsenic-induced decreases of serum testosterone, and testicular reduced glutathione level, and significantly decreased the elevations of testicular malondialdehyde and nitric oxide levels resulted from arsenic administration. Also, TQ ameliorated the arsenic-induced testicular tissue injury observed by histopathological examination. In addition, TQ decreased the arsenic-induced expression of inducible nitric oxide synthase and caspase-3 in testicular tissue. It was concluded that TQ may represent a potential candidate to protect against arsenic-induced testicular injury. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thymoquinone" title="thymoquinone">thymoquinone</a>, <a href="https://publications.waset.org/abstracts/search?q=arsenic" title=" arsenic"> arsenic</a>, <a href="https://publications.waset.org/abstracts/search?q=testes" title=" testes"> testes</a>, <a href="https://publications.waset.org/abstracts/search?q=rats" title=" rats"> rats</a> </p> <a href="https://publications.waset.org/abstracts/6289/protective-effect-of-thymoquinone-against-arsenic-induced-testicular-toxicity-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6289.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">298</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2163</span> Transverse Testicular Ectopia: A Case Report with Review of Literature</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rida%20Ahmad">Rida Ahmad</a>, <a href="https://publications.waset.org/abstracts/search?q=Areej%20S.%20Habib"> Areej S. Habib</a>, <a href="https://publications.waset.org/abstracts/search?q=Sohail%20A.%20Dogar"> Sohail A. Dogar</a>, <a href="https://publications.waset.org/abstracts/search?q=Saqib%20H.%20Qazi"> Saqib H. Qazi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Transverse testicular ectopia is a rare congenital disorder involving mal descent and mal-positioning of the testes, reported in the medical literature about 300 times. Many theories attempt to explain the failure of the testes to migrate to their correct location. While the age at presentation can vary; most cases present in early adolescents or late adulthood. It is often an incidental discovery made during an operative intervention, most commonly during hernia exploration. It can be isolated or present with a plethora of anomalies. We present the case of a 2-year-old male with transverse testicular ectopia who presented with vague abdominal pain. He was managed successfully with the Modified Ombredanne procedure and good outcome 6 months after the procedure. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cryptorchidism" title="cryptorchidism">cryptorchidism</a>, <a href="https://publications.waset.org/abstracts/search?q=persistent%20Mullerian%20duct%20syndrome" title=" persistent Mullerian duct syndrome"> persistent Mullerian duct syndrome</a>, <a href="https://publications.waset.org/abstracts/search?q=transverse%20testicular%20ectopia" title=" transverse testicular ectopia"> transverse testicular ectopia</a>, <a href="https://publications.waset.org/abstracts/search?q=testicular%20mal-descent" title=" testicular mal-descent"> testicular mal-descent</a> </p> <a href="https://publications.waset.org/abstracts/141125/transverse-testicular-ectopia-a-case-report-with-review-of-literature" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141125.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">341</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2162</span> Origanum vulgare as a Possible Modulator of Testicular Endocrine Function in Mice </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eva%20Tvrd%C3%A1">Eva Tvrdá</a>, <a href="https://publications.waset.org/abstracts/search?q=Barbora%20Babe%C4%8Dkov%C3%A1"> Barbora Babečková</a>, <a href="https://publications.waset.org/abstracts/search?q=Michal%20%C4%8Eura%C4%8Dka"> Michal Ďuračka</a>, <a href="https://publications.waset.org/abstracts/search?q=R%C3%B3bert%20Kirchner"> Róbert Kirchner</a>, <a href="https://publications.waset.org/abstracts/search?q=J%C3%BAlius%20%C3%81rvay"> Július Árvay</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study was designed to assess the <em>in vitro</em> effects of <em>Origanum vulgare</em> L. (oregano) extract on the testicular steroidogenesis. We focused on identifying major biomolecules present in the oregano extract, as well as to investigate its <em>in vitro</em> impact on the secretion of cholesterol, testosterone, dehydroepiandrosterone and androstenedione by murine testicular fragments. The extract was subjected to high performance liquid chromatography (HPLC) which identified cyranosid, daidzein, thymol, rosmarinic and trans-caffeic acid among the predominant biochemical components of oregano. For the <em>in vitro</em> experiments, testicular fragments from 20 sexually mature Institute of Cancer Research (ICR) mice were incubated in the absence (control group) or presence of the oregano extract at selected concentrations (10, 100 and 1000 μg/mL) for 24 h. Cholesterol levels were quantified using photometry and the hormones were assessed by ELISA (Enzyme-Linked Immunosorbent Assay). Our data revealed that the release of cholesterol and androstenedione (but not dehydroepiandrosterone and testosterone) by the testicular fragments was significantly impacted by the oregano extract in a dose-dependent fashion. Supplementation of the extract resulted in a significant decline of cholesterol (P < 0.05 in case of 100 μg/mL; P < 0.01 with respect 100 μg/mL extract), as well as androstenedione (P < 0.01 with respect to 100 and 1000 μg/mL extract). Our results suggest that the biomolecules present in <em>Origanum vulgare</em> L. could exhibit a dose-dependent impact on the secretion of male steroids, playing a role in the regulation of testicular steroidogenesis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mice" title="mice">mice</a>, <a href="https://publications.waset.org/abstracts/search?q=Origanum%20vulgare%20L." title=" Origanum vulgare L."> Origanum vulgare L.</a>, <a href="https://publications.waset.org/abstracts/search?q=steroidogenesis" title=" steroidogenesis"> steroidogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=testes" title=" testes "> testes </a> </p> <a href="https://publications.waset.org/abstracts/108962/origanum-vulgare-as-a-possible-modulator-of-testicular-endocrine-function-in-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/108962.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">167</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2161</span> Literature Review of Rare Synchronous Tumours</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Diwei%20Lin">Diwei Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Amanda%20Tan"> Amanda Tan</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajinder%20Singh-Rai"> Rajinder Singh-Rai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We present the first reported case of a concomitant Leydig cell tumor (LCT) and paratesticular leiomyoma in an adult male with a known history of bilateral cryptorchidism. An 80-year-old male presented with a 2-month history of a left testicular lump associated with mild discomfort and a gradual increase in size on a background of bilateral cryptorchidism requiring multiple orchidopexy procedures as a child. Ultrasound confirmed a lesion suspicious for malignancy and he proceeded to a left radical orchidectomy. Histopathological assessment of the left testis revealed a concomitant testicular LCT with malignant features and paratesticular leiomyoma. Leydig cell tumors (LCTs) are the most common pure testicular sex cord-stromal tumors, accounting for up to 3% of all testicular tumors. They can occur at almost any age, but are noted to have a bi-modal distribution, with a peak incidence at 6 to 10 and at 20 to 50 years of age. LCT’s are often hormonally active and can lead to feminizing or virilizing syndromes. LCT’s are usually regarded as benign but can rarely exhibit malignant traits. Paratesticular tumours are uncommon and their reported prevalence varies between 3% and 16%. They occur in a complex anatomical area which includes the contents of the spermatic cord, testicular tunics, epididymis and vestigial remnants. Up to 90% of paratesticular tumours are believed to originate from the spermatic cord, though it is often difficult to definitively ascertain the exact site of origin. Although any type of soft-tissue neoplasm can be found in the paratesticular region, the most common benign tumors reported are lipomas of the spermatic cord, adenomatoid tumours of the epididymis and leiomyomas of the testis. Genetic studies have identified potential mutations that could potentially cause LCTs, but there are no known associations between concomitant LCTs and paratesticular tumors. The presence of cryptorchidism in adults with both LCTs and paratesticular neoplasms individually has been previously reported and it appears intuitive that cryptorchidism is likely to be associated with the concomitant presentation in this case report. This report represents the first documented case in the literature of a unilateral concomitant LCT and paratesticular leiomyoma on a background of bilateral cryptorchidism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=testicular%20cancer" title="testicular cancer">testicular cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=leydig%20cell%20tumour" title=" leydig cell tumour"> leydig cell tumour</a>, <a href="https://publications.waset.org/abstracts/search?q=leiomyoma" title=" leiomyoma"> leiomyoma</a>, <a href="https://publications.waset.org/abstracts/search?q=paratesticular%20neoplasms" title=" paratesticular neoplasms"> paratesticular neoplasms</a> </p> <a href="https://publications.waset.org/abstracts/9864/literature-review-of-rare-synchronous-tumours" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9864.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">361</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2160</span> Reversal of Testicular Damage and Subfertility by Resveratrol </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Samy%20S.%20Eleawa">Samy S. Eleawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahmoud%20A.%20Alkhateeb"> Mahmoud A. Alkhateeb</a>, <a href="https://publications.waset.org/abstracts/search?q=Fahaid%20H.%20Alhashem"> Fahaid H. Alhashem</a>, <a href="https://publications.waset.org/abstracts/search?q=Ismaeel%20bin-Jaliah"> Ismaeel bin-Jaliah</a>, <a href="https://publications.waset.org/abstracts/search?q=Hussein%20F.%20Sakr"> Hussein F. Sakr</a>, <a href="https://publications.waset.org/abstracts/search?q=Hesham%20M.%20Elrefaey"> Hesham M. Elrefaey</a>, <a href="https://publications.waset.org/abstracts/search?q=Abbas%20O.%20Elkarib"> Abbas O. Elkarib</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20A.%20Haidara"> Mohammad A. Haidara</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20S.%20Shatoor"> Abdullah S. Shatoor</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20A.%20Khalil"> Mohammad A. Khalil</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This effect of Resveratrol (RES) against CdCl2- induced toxicity in the rat testes was investigated. Seven experimental groups of adult male rats were formulated as follows: A) Controls + NS, B) Control+ vehicle (saline solution of hydroxypropyl cyclodextrin), C) RES treated, D) CdCl2 +NS, E) CdCl2+ vehicle, F) RES followed by CdCl2 and M) CdCl2 followed by RES. At the end of the protocol, serum levels of FSH, LH, and testosterone were measured in all groups. Testicular levels of TBARS and Super Oxide Dismutase (SOD) activity were also measured. Epidydidimal semen analysis was performed and testicular expression of Bcl-2, p53 and Bax were assessed by RT-PCR. Also, histopathological changes of testes were examined microscopically and described. Pre and Post administration of RES in cadmium chloride-intoxicated rats improved semen parameters including count, motility, daily sperm production and morphology, increased serum concentrations of gonadotropins and testosterone, decreased testicular lipid peroxidation and increased SOD activity. Not only RES attenuated cadmium chloride induced testicular histopathology but was also able to protect against the onset of cadmium chloride testicular toxicity. Cadmium chloride downregulated the anti-apoptotic gene Bcl2 and upregulated the expression of both pro-apoptotic genes p53 and Bax. Resveratrol protected from and partially reversed cadmium chloride testicular via upregulation of Bcl2 and down regulation of p53 and Bax gene expression. Antioxidant activity of RES protects against cadmium chloride testicular toxicity and partially reverses its effect via upregulation of BCl2 and downregulation of p53 and Bax expression. These findings have far reaching implications on subfertility and impotency frequently seen in hypertensive as well as metabolic syndrome patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=resveratrol" title="resveratrol">resveratrol</a>, <a href="https://publications.waset.org/abstracts/search?q=cadmium" title=" cadmium"> cadmium</a>, <a href="https://publications.waset.org/abstracts/search?q=infertility" title=" infertility"> infertility</a>, <a href="https://publications.waset.org/abstracts/search?q=sperm" title=" sperm"> sperm</a>, <a href="https://publications.waset.org/abstracts/search?q=testis" title=" testis"> testis</a>, <a href="https://publications.waset.org/abstracts/search?q=metabolic%20syndrome" title=" metabolic syndrome"> metabolic syndrome</a> </p> <a href="https://publications.waset.org/abstracts/24438/reversal-of-testicular-damage-and-subfertility-by-resveratrol" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24438.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">535</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2159</span> Relationship between Trauma and Acute Scrotum: Test Torsion and Epididymal Appendix Torsion</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saimir%20Heta">Saimir Heta</a>, <a href="https://publications.waset.org/abstracts/search?q=Kastriot%20Haxhirexha"> Kastriot Haxhirexha</a>, <a href="https://publications.waset.org/abstracts/search?q=Virtut%20Velmishi"> Virtut Velmishi</a>, <a href="https://publications.waset.org/abstracts/search?q=Nevila%20Alliu"> Nevila Alliu</a>, <a href="https://publications.waset.org/abstracts/search?q=Ilma%20Robo"> Ilma Robo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Testicular rotation can occur at any age. The possibility to save the testicle is the fastest possible surgical intervention which is indicated by the presence of acute pain even at rest. The time element is more important to diagnose and proceed further with surgical intervention. Testicular damage is a consequence which mainly depends on the moment of onset of symptoms, at the time when the symptoms are diagnosed, the earliest action to be performed is surgical intervention. Sometimes medical tests are needed to confirm a diagnosis, or to help identify another cause for symptoms; for example, the urine test, that is used to check for infection, associated with the scrotal ultrasound test. Control of blood flow to the longitudinal supply vessels of the testicles is indicated. The sign that indicates testicular rotation is a reduction in blood flow. This is the element which is distinguished from ultrasound examination. Surgery may be needed to determine if the patient’s symptoms are caused by the rotation of the testis or any other condition. Discussion: As a surgical intervention of the emergency, the torsion of the test depends very much on the duration of the torsion, as the success in the life of the testicle depends on the fastest surgical intervention. From the previous clinic, it is noted that in any case presented to the pediatric patient diagnosed with testicular rotation, there is always a link with personal history that the patient refers to the presence of a previous episode of testicular trauma. Literature supports this fact very logically. Conclusions: Salvation without testicular atrophy depends closely on establishing the diagnosis of testicular rotation as soon as possible. Following the logic above, it can be said that the diagnosis for rotation should be performed as soon as possible, to avoid consequences that will not be favorable for the patient. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20scrotum" title="acute scrotum">acute scrotum</a>, <a href="https://publications.waset.org/abstracts/search?q=test%20torsion" title=" test torsion"> test torsion</a>, <a href="https://publications.waset.org/abstracts/search?q=newborns" title=" newborns"> newborns</a>, <a href="https://publications.waset.org/abstracts/search?q=clinical%20presentation" title=" clinical presentation"> clinical presentation</a> </p> <a href="https://publications.waset.org/abstracts/130384/relationship-between-trauma-and-acute-scrotum-test-torsion-and-epididymal-appendix-torsion" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/130384.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">150</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2158</span> Colonization of Embrionic Gonads of Nile Tilapia by Giant Gourami Testicular Germ Cells </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Irma%20Andriani">Irma Andriani</a>, <a href="https://publications.waset.org/abstracts/search?q=Ita%20Djuwita"> Ita Djuwita</a>, <a href="https://publications.waset.org/abstracts/search?q=Komar%20Sumantadinata"> Komar Sumantadinata</a>, <a href="https://publications.waset.org/abstracts/search?q=Alimuddin"> Alimuddin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The recent study has been conducted to develop testicular germ cell transplantation as a tool for preservation and propagation of male germ-plasm from endangered fish species, as well as to produce surrogate broodstock of commercially valuable fish. Giant gourami testis had been used as a model for donor and Nile tilapia larvae as recipient. We developed testicular cell xenotransplantation by optimizing the timing of intraperitoneal cell transplantation to recipient larvae aged 1, 3, 5 and 7 days post hatching (dph). Freshly isolated testis of giant gourami weighing 600–800 g were minced in dissociation medium and then incubated for 3 hours in room temperature to collect monodisperce cell suspension. Donor cells labeled with PKH 26 were transplanted into the peritoneal cavity of Nile tilapia larvae using glass micropipettes. Parameters observed were survival rate of Nile tilapia larvae at 24 hours post transplantation (pt) and colonization efficiency of donor cells at 2 and 3 months pt. The incorporated donor cells were observed under fluorescent microscope. The result showed that the lowest survival rate at 24 hours pt was 1 dph larvae (82.74±6.76%) and the highest survival rate were 3 and 5 dph larvae (95.00±5.00% and 95.00±2.50%, respectively). The highest colonization efficiency was on 3 dph larvae (61.1±34.71%) and the lowest colonization efficiency was on 7 dph larvae (19.43±17.33%). In conclusion, 3 dph Nile tilapia larvae was the best recipient for giant gourami testicular germ cells xenotransplantation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=xenotransplantation" title="xenotransplantation">xenotransplantation</a>, <a href="https://publications.waset.org/abstracts/search?q=testicular%20germ%20cell" title=" testicular germ cell"> testicular germ cell</a>, <a href="https://publications.waset.org/abstracts/search?q=giant%20gourami" title=" giant gourami"> giant gourami</a>, <a href="https://publications.waset.org/abstracts/search?q=Nile%20tilapia" title=" Nile tilapia"> Nile tilapia</a>, <a href="https://publications.waset.org/abstracts/search?q=colonization%20efficiency" title=" colonization efficiency"> colonization efficiency</a> </p> <a href="https://publications.waset.org/abstracts/10265/colonization-of-embrionic-gonads-of-nile-tilapia-by-giant-gourami-testicular-germ-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10265.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">582</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2157</span> Influence of Age on Some Testicular and Spermatic Parameters in Kids and Bucks in Local Breed Arbia in Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Boukhalfa%20Djemouai">Boukhalfa Djemouai</a>, <a href="https://publications.waset.org/abstracts/search?q=Belkadi%20Souhila"> Belkadi Souhila</a>, <a href="https://publications.waset.org/abstracts/search?q=Safsaf%20Boubakeur"> Safsaf Boubakeur</a> </p> <p class="card-text"><strong>Abstract:</strong></p> To increase the profitability of the national herd so that it can meet the needs of the population, Algeria has proceeded to the introduction of new reproductive biotechnologies, including artificial insemination on natural heat, by induction and heat synchronization. This biotechnology uses the male way for the creation and dissemination of genetic progress. The study has focused on 30 goat kids and bucks local breed aged between 03 and 24 months, divided into 03 groups 03-06 months[Grp 1; n=9], 07-10 months [Grp 2; n=13] and 11-24 months [Grp 3; n=8], in order to determine the influence of age on testicular evolution by measurements of testis and scrotum, and the epididymis sperm parameters evaluation. These parameters are influenced by age variations (sperm and spermocytogram). The examined parameters have focused on testicular weight (grams), the scrotal circumference (cm), mass mobility (%), vitality rate (%), sperm concentration (x 109), and percentage of abnormal spermatozoa (%). The ANOVA reveals a significance effect of age on parameters: testis weight, scrotal circumference, sperm concentration, motility varying between high (p < 0.01) to very high significance (p < 0.001), while in viability and abnormalities no significance was observed between all groups. The value of these parameters increased significantly until the age of 02 years, while that of sperm abnormalities has increased in Grp2. The histological study of testicular development shows that the genetic spermatozoa function characterized by cell proliferation, which is more and more intense starting from the age of 05 months and can be considered as an age of puberty in the local breed goat Arbia and increases with animal age. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=kids%20and%20bucks" title="kids and bucks">kids and bucks</a>, <a href="https://publications.waset.org/abstracts/search?q=epididymis%20sperm" title=" epididymis sperm"> epididymis sperm</a>, <a href="https://publications.waset.org/abstracts/search?q=testicular%20measurements" title=" testicular measurements"> testicular measurements</a>, <a href="https://publications.waset.org/abstracts/search?q=Arbia%20breed" title=" Arbia breed"> Arbia breed</a> </p> <a href="https://publications.waset.org/abstracts/125017/influence-of-age-on-some-testicular-and-spermatic-parameters-in-kids-and-bucks-in-local-breed-arbia-in-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/125017.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">132</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2156</span> A Left Testicular Cancer with Multiple Metastases Nursing Experience</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Syue-Wen%20Lin">Syue-Wen Lin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective:This article reviews the care experience of a 40-year-old male patient who underwent a thoracoscopic right lower lobectomy following a COVID-19 infection. His complex medical history included multiple metastases (lungs, liver, spleen, and left kidney) and lung damage from COVID-19, which complicated the weaning process from mechanical ventilation. The care involved managing cancer treatment, postoperative pain, wound care, and palliative care. Methods:Nursing care was provided from August 16 to August 17, 2024. Challenges included difficulty with sputum clearance, which exacerbated the patient's anxiety and fear of reintubation. Pain management strategies combined analgesic drugs, non-drug methods, essential oil massages with family members, and playing the patient’s favorite music to reduce pain and anxiety. Progressive rehabilitation began with stabilizing vital signs, followed by assistance with sitting on the edge of the bed and walking within the ward. Strict sterile procedures and advanced wound care technology were used for daily dressing changes, with meticulous documentation of wound conditions and appropriate dressing selection. Holistic cancer care and palliative measures were integrated to address the patient’s physical and psychological needs. Results:The interdisciplinary care team developed a comprehensive plan addressing both physical and psychological aspects. Respiratory therapy, lung expansion exercises, and a high-frequency chest wall oscillation vest facilitated sputum expulsion and assisted in weaning from mechanical ventilation. The integration of cancer care, pain management, wound care, and palliative care led to improved quality of life and recovery. The collaborative approach between nursing staff and family ensured that the patient received compassionate and effective care. Conclusion: The complex interplay of emergency surgery, COVID-19, and advanced cancer required a multifaceted care strategy. The care team’s approach, combining critical care with tailored cancer and palliative care, effectively improved the patient’s quality of life and facilitated recovery. The comprehensive care plan, developed with family collaboration, provided both high-quality medical care and compassionate support for the terminally ill patient. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multiple%20metastases" title="multiple metastases">multiple metastases</a>, <a href="https://publications.waset.org/abstracts/search?q=testicular%20cancer" title=" testicular cancer"> testicular cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=palliative%20care" title=" palliative care"> palliative care</a>, <a href="https://publications.waset.org/abstracts/search?q=nursing%20experience" title=" nursing experience"> nursing experience</a> </p> <a href="https://publications.waset.org/abstracts/190164/a-left-testicular-cancer-with-multiple-metastases-nursing-experience" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/190164.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">22</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2155</span> The Effect of β-Cryptoxanthin on Testicular Ischemia-Reperfusion Injury in a Rat Model: Evidence from Testicular Histology</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kianoush%20Mohammadnejad">Kianoush Mohammadnejad</a>, <a href="https://publications.waset.org/abstracts/search?q=Rahim%20Mohammadi"> Rahim Mohammadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Soleimanzadeh"> Ali Soleimanzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Shalizar%20Jalai"> Ali Shalizar Jalai</a>, <a href="https://publications.waset.org/abstracts/search?q=Farshid%20Sareafzadeh%20Rezaei"> Farshid Sareafzadeh Rezaei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Testicular torsion and detorsion are significant clinical issues for infertile men. Torsion of the spermatic cord is an emergency condition resulting from the rotation of the testis and epididymis around the axis of the spermatic cord. A rat testis model was used to assess the effects of β-cryptoxanthin on ischemia-reperfusion injury. Twenty healthy male Wistar rats were included and randomized into four investigational groups (n = 5): Group SHAM: In this group, midline incision of the scrotum was performed, and the testicles were taken out for 2 hours with a 720-degree rotation. Group ISCHEMIA: In this group, a midline incision of the scrotum was performed, and the testicles were taken out and underwent ischemia for 2 hours with a 720-degree rotation. Group IS/REP/Oil: In this group, a midline scrotum cut was performed the testicles were taken out, and ischemia was created for 2 hours with a 720-degree rotation and at the end of ischemia 100 µL of corn oil (β-cryptoxanthin solvent) was injected intraperitoneally. Group IS/REP/CRPTXNTN 2.5: The same as group IS/REP/Oil as well as intraperitoneal administration of 100 µL of β-cryptoxanthin (2.5 µg/kg) at the end of ischemia. In all groups, the testes were returned back to the scrotum and, after 60 days, were dissected out and removed for histopathological analyses. β-cryptoxanthin at the dose of 2.5 µg/kg significantly improved histologic indices compared to other treatment groups (p<0.05). β-cryptoxanthin could be helpful in minimizing ischemia-reperfusion injury in testicular tissue exposed to ischemia. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta-cryptoxanthin" title="beta-cryptoxanthin">beta-cryptoxanthin</a>, <a href="https://publications.waset.org/abstracts/search?q=testis" title=" testis"> testis</a>, <a href="https://publications.waset.org/abstracts/search?q=Ischemia-reperfusion" title=" Ischemia-reperfusion"> Ischemia-reperfusion</a>, <a href="https://publications.waset.org/abstracts/search?q=Intraperitoneal" title=" Intraperitoneal"> Intraperitoneal</a> </p> <a href="https://publications.waset.org/abstracts/189306/the-effect-of-v-cryptoxanthin-on-testicular-ischemia-reperfusion-injury-in-a-rat-model-evidence-from-testicular-histology" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/189306.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">18</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2154</span> Comparison of Two Methods of Cryopreservation of Testicular Tissue from Prepubertal Lambs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rensson%20Homero%20Celiz%20Ygnacio">Rensson Homero Celiz Ygnacio</a>, <a href="https://publications.waset.org/abstracts/search?q=Marco%20Aur%C3%A9lio%20Schiavo%20Novaes"> Marco Aurélio Schiavo Novaes</a>, <a href="https://publications.waset.org/abstracts/search?q=Lucy%20Vanessa%20Sulca%20%C3%91aupas"> Lucy Vanessa Sulca Ñaupas</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Paula%20Ribeiro%20Rodrigues"> Ana Paula Ribeiro Rodrigues</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The cryopreservation of testicular tissue emerges as an alternative for the preservation of the reproductive potential of individuals who still cannot produce sperm; however, they will undergo treatments that may affect their fertility (e.g., chemotherapy). Therefore, the present work aims to compare two cryopreservation methods (slow freezing and vitrification) in testicular tissue of prepubertal lambs. For that, to obtain the testicular tissue, the animals were castrated and the testicles were collected immediately in a physiological solution supplemented with antibiotics. In the laboratory, the testis was split into small pieces. The total size of the testicular fragments was 3×3x1 mm³ and was placed in a dish contained in Minimum Essential Medium (MEM-HEPES). The fragments were distributed randomly into non-cryopreserved (fresh control), slow freezing (SF), and vitrified. To SF procedures, two fragments from a given male were then placed in a 2,0 mL cryogenic vial containing 1,0 mL MEM-HEPES supplemented with 20% fetal bovine serum (FBS) and 20% dimethylsulfoxide (DMSO). Tubes were placed into a Mr. Frosty™ Freezing container with isopropyl alcohol and transferred to a -80°C freezer for overnight storage. On the next day, each tube was plunged into liquid nitrogen (NL). For vitrification, the ovarian tissue cryosystem (OTC) device was used. Testicular fragments were placed in the OTC device and exposed to the first vitrification solution composed of MEM-HEPES supplemented with 10 mg/mL Bovine Serum Albumin (BSA), 0.25 M sucrose, 10% Ethylene glycol (EG), 10% DMSO and 150 μM alpha-lipoic acid for four min. The VS1 was discarded and then the fragments were submerged into a second vitrification solution (VS2) containing the same composition of VS1 but 20% EG and 20% DMSO. VS2 was then discarded and each OTC device containing up to four testicular fragments was closed and immersed in NL. After the storage period, the fragments were removed from the NL, kept at room temperature for one min and then immersed at 37 °C in a water bath for 30 s. Samples were warmed by sequentially immersing in solutions of MEM-HEPES supplemented with 3 mg/mL BSA and decreasing concentrations of sucrose. Hematoxylin-eosin staining to analyze the tissue architecture was used. The score scale used was from 0 to 3, classified with a score 0 representing normal morphologically, and 3 were considered a lot of alteration. The histomorphological evaluation of the testicular tissue shows that when evaluating the nuclear alteration (distinction of nucleoli and condensation of nuclei), there are no differences when using slow freezing with respect to the control. However, vitrification presents greater damage (p <0.05). On the other hand, when evaluating the epithelial alteration, we observed that the freezing showed scores statistically equal to the control in variables such as retraction of the basement membrane, formation of gaps and organization of the peritubular cells. The results of the study demonstrated that cryopreservation using the slow freezing method is an excellent tool for the preservation of pubertal testicular tissue. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cryopreservation" title="cryopreservation">cryopreservation</a>, <a href="https://publications.waset.org/abstracts/search?q=slow%20freezing" title=" slow freezing"> slow freezing</a>, <a href="https://publications.waset.org/abstracts/search?q=vitrification" title=" vitrification"> vitrification</a>, <a href="https://publications.waset.org/abstracts/search?q=testicular%20tissue" title=" testicular tissue"> testicular tissue</a>, <a href="https://publications.waset.org/abstracts/search?q=lambs" title=" lambs"> lambs</a> </p> <a href="https://publications.waset.org/abstracts/142928/comparison-of-two-methods-of-cryopreservation-of-testicular-tissue-from-prepubertal-lambs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142928.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">174</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2153</span> Effects of Dietary E on Semen, Hormonal Profile and Testicular Biometry in Teddy Goat Bucks</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Zubair">Muhammad Zubair</a>, <a href="https://publications.waset.org/abstracts/search?q=Maqbool%20Ahmad"> Maqbool Ahmad</a>, <a href="https://publications.waset.org/abstracts/search?q=Al-Hafizah%20Shafia%20Tehseen%20Gul"> Al-Hafizah Shafia Tehseen Gul</a>, <a href="https://publications.waset.org/abstracts/search?q=Shujait%20Ali"> Shujait Ali </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The use of vitamins has significant effects on the reproductive system of mammals. The present study was conducted to investigate the useful effects of vitamin E on reproductive functions of Teddy bucks. For this purpose, 8 adult Teddy bucks were randomly divided into two treatment groups viz; A (control) and B (vitamin E with dose of 200 mg/kg BW/day). These treatments continued for 12 weeks. Semen quality parameters (volume, motility, sperm morphology and sperm DNA integrity) of experimental bucks of each group was evaluated on weekly basis, while testicular measurements (length, scrotal circumference and weights) were recorded at 0 and 12th week of experiment. Serum concentrations of male sex hormones (testosterone, LH, FSH) and cortisol were recorded fortnightly. Similarly, body weights of bucks were also measured fortnightly until completion of the study. The data were subjected to two-way analysis of variance, followed by Duncan test for multiple mean comparisons. Supplementation of vitamin E improved significantly (P<0.05) the semen quality parameter, body weights, testicular measurements and serum levels of sex hormones. However, there was no effect on serum cortisol. It was concluded from the present study that dietary supplementation of vitamin E has beneficial effects on the semen and hormones in male reproductive system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hormones" title="hormones">hormones</a>, <a href="https://publications.waset.org/abstracts/search?q=semen" title=" semen"> semen</a>, <a href="https://publications.waset.org/abstracts/search?q=teddy%20bucks" title=" teddy bucks"> teddy bucks</a>, <a href="https://publications.waset.org/abstracts/search?q=testicular%20measurements" title=" testicular measurements"> testicular measurements</a> </p> <a href="https://publications.waset.org/abstracts/54209/effects-of-dietary-e-on-semen-hormonal-profile-and-testicular-biometry-in-teddy-goat-bucks" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54209.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">292</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2152</span> Protective Effects of Vitamin C and Vitamin E on Experimentally Induced Testicular Torsion and Detorsion in Rat Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anu%20Vinod%20Ranade">Anu Vinod Ranade</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: To evaluate and compare the effects of Vitamin C and Vitamin E on experimentally induced testicular torsion and detorsion in rats. Methods: Forty Male Wistar Albino rats were divided into five groups. Animals in the Group I underwent Sham operation, Group II consisted of animals that were subjected to torsion for three hours followed by detorsion for 24 hours without any treatment. While Group III, IV and V were orally pretreated with Vitamin C (40mg/kg.bw), vitamin E (100mg/kg.bw) and a combination of Vitamin C and vitamin E respectively for a period of 30 days. The testes of the experimental groups were manually rotated to 720° clockwise for three hours and counter rotated for 24 hours to induce ischemia and reperfusion. Sequential biopsies were performed and the testes were collected at the end of 24 hours of detrosion for morphological evaluation. Result: There was a significant decrease in the standard tubular diameter and the epithelial height of the seminiferous tubules in the untreated group when compared to Sham controls. The standard tubular diameter and seminiferous epithelial height showed near normal values when animals were pretreated with Vitamin C and Vitamin E individually or in combination. Conclusion: The results showed that pretreatment of with antioxidants vitamin E and vitamin C when administered prior to testicular torsion in rats significantly reduced the torsion and detorsion induced histopathlogical injury. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=vitamin%20C" title="vitamin C">vitamin C</a>, <a href="https://publications.waset.org/abstracts/search?q=vitamin%20E" title=" vitamin E"> vitamin E</a>, <a href="https://publications.waset.org/abstracts/search?q=standard%20tubular%20diameter" title=" standard tubular diameter"> standard tubular diameter</a>, <a href="https://publications.waset.org/abstracts/search?q=standard%20epithelial%20height" title=" standard epithelial height"> standard epithelial height</a>, <a href="https://publications.waset.org/abstracts/search?q=testicular%20torsion" title=" testicular torsion"> testicular torsion</a> </p> <a href="https://publications.waset.org/abstracts/29446/protective-effects-of-vitamin-c-and-vitamin-e-on-experimentally-induced-testicular-torsion-and-detorsion-in-rat-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29446.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">315</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2151</span> The Effects of Androgen Receptor Mutation on Cryptorchid Testes in 46, XY Female </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ihtisham%20Bukhari">Ihtisham Bukhari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the current study, we enrolled a 46, XY phenotypically female patient bearing testes in her inguinal canal. DNA sequencing of the AR gene detected a missense mutation C.1715A > G (p. Y572C) in exon 2 which is already known to cause Complete androgen insensitivity syndrome (CAIS). We further studied the effects of this mutation on the testicular histopathology of the patient. No spermatocytes were seen in the surface spreading of testicular tissues while H&E staining showed that seminiferous tubules predominantly have only Sertoli cells. To confirm this meiotic failure is likely due to the current AR mutation we performed mRNA expression of genes associated with AR pathway, expression and location of the associated proteins in testicular tissues. Western blot and real-time PCR data showed that the patient had high levels of expression of AMH, SOX9, and INNB in testis. Tubules were stained with SOX9 and AMH which revealed Sertoli cell maturation arrest. Therefore, we suggest that AR mutation enhances AMH expression which ultimately leads to failure in the maturation of Sertoli cells and failure in spermatogenesis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androgen%20receptor" title="androgen receptor">androgen receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=spermatogenesis" title=" spermatogenesis"> spermatogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=infertility" title=" infertility"> infertility</a>, <a href="https://publications.waset.org/abstracts/search?q=Sertoli%20cell%20only%20syndrome" title=" Sertoli cell only syndrome"> Sertoli cell only syndrome</a> </p> <a href="https://publications.waset.org/abstracts/90798/the-effects-of-androgen-receptor-mutation-on-cryptorchid-testes-in-46-xy-female" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/90798.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">143</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2150</span> Oxidative and Hormonal Disruptions Underlie Bisphenol A: Induced Testicular Toxicity in Male Rabbits</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kadry%20M.%20Sadek">Kadry M. Sadek</a>, <a href="https://publications.waset.org/abstracts/search?q=Tarek%20K.%20Abouzed"> Tarek K. Abouzed</a>, <a href="https://publications.waset.org/abstracts/search?q=Mousa%20A.%20Ayoub"> Mousa A. Ayoub</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The presence of endocrine-disrupting compounds, such as bisphenol A (BPA), in the environment can cause serious health problems. However, there are controversial opinions. This study investigated the reproductive, metabolic, oxidative and immunologic-disrupting effects of bisphenol A in male rabbits. Rabbits were divided into five groups. The first four rabbit groups were administered oral BPA (1, 10, 50, or 100 mg/kg/day) for ten weeks. The fifth group was administered corn oil as the vehicle. BPA significantly decreased serum testosterone, estradiol and the free androgen index (FAI) and significantly increased sex hormone binding globulin (SHBG) compared with the placebo group. The higher doses of BPA showed a significant decrease in follicular stimulating hormone (FSH) and luteinizing hormone (LH). A significant increase in blood glucose levels was identified in the BPA groups. The non-significant difference in insulin levels is a novel finding. The cumulative testicular toxicity of BPA was clearly demonstrated by the dose-dependent decrease in absolute testes weight, primary measures of semen quality and a significant increase in testicular malonaldehyde (MDA). Moreover, BPA significantly decreased total antioxidant capacity (TAC) and significantly increased immunoglobulin G (IgG) at the highest concentration. Our results suggest that BPA, especially at higher doses, is associated with many adverse effects on metabolism, oxidative stress, immunity, sperm quality and markers of androgenic action. These results may reflect the estrogenic effects of BPA, which we hypothesize could be related, in part, to an inhibitory effect on testicular steroidogenesis. The induction of oxidative stress by BPA may play an additional role in testicular toxicity. These results suggest that BPA poses a threat to endocrine and reproductive functions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bisphenol%20A" title="bisphenol A">bisphenol A</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=rabbits" title=" rabbits"> rabbits</a>, <a href="https://publications.waset.org/abstracts/search?q=semen%20quality" title=" semen quality"> semen quality</a>, <a href="https://publications.waset.org/abstracts/search?q=steroidogenesis" title=" steroidogenesis"> steroidogenesis</a> </p> <a href="https://publications.waset.org/abstracts/14594/oxidative-and-hormonal-disruptions-underlie-bisphenol-a-induced-testicular-toxicity-in-male-rabbits" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14594.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">294</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2149</span> Dexamethasone: Impact on Testicular Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sadi-Guettaf%20Hassiba">Sadi-Guettaf Hassiba</a>, <a href="https://publications.waset.org/abstracts/search?q=Hadj-Bekkouche%20Fatima"> Hadj-Bekkouche Fatima</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dexamethasone (Dex) is a synthetic glucocorticoid that is used in therapy. However prolonged treatments with high doses are often required. This causes side effects that interfere with the activity of several endocrine systems, including the gonadotropic axis. The aim of our study is to determine the effect of Dex on testicular function in prepubertal Wistar rats. Newborn Wistar rats are submitted to intraperitoneal injection of Dex (1μg of Dex dissolved in NaCl 0.9% / 5g bw) for 20 days and then sacrificed at the age of 40days. A control group received NaCl 0.9%. The rat is weighed daily. The plasmatic levels of testosterone, LH and FSH were measured by radioimmunoassay. A histo-morphometric study was performed on sections of testis. Treated groups showed a significant decrease in body weight (p < 0.05), testis weight (p < 0.05) and plasma levels of testosterone (p < 0.05), of LH (P < .05) and FSH (p> 0.05). There is a reduction of seminiferous tubules average diameter and also of the seminiferous epithelium thickness with an increasing of lumen tubular. The diameter of the Leydig cells and Sertoli cell nucleus is also significantly reduced. Spermatogenesis is blocked at the stage round spermatid unlike witnesses or elongated spermatid stage is found. These results suggest that Dex administered during neonatal life influences testicular activity in the long term. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dexamethasone" title="dexamethasone">dexamethasone</a>, <a href="https://publications.waset.org/abstracts/search?q=FSH" title=" FSH"> FSH</a>, <a href="https://publications.waset.org/abstracts/search?q=LH" title=" LH"> LH</a>, <a href="https://publications.waset.org/abstracts/search?q=rat" title=" rat"> rat</a>, <a href="https://publications.waset.org/abstracts/search?q=testis" title=" testis"> testis</a>, <a href="https://publications.waset.org/abstracts/search?q=testosterone" title=" testosterone"> testosterone</a> </p> <a href="https://publications.waset.org/abstracts/11940/dexamethasone-impact-on-testicular-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/11940.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">269</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2148</span> Testicular Dose and Associated Risk from Common Pelvis Radiation Therapy in Iran</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahmad%20Shanei">Ahmad Shanei</a>, <a href="https://publications.waset.org/abstracts/search?q=Milad%20Baradaran-Ghahfarokhi"> Milad Baradaran-Ghahfarokhi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study aimed to investigate testicular dose (TD) and the associated risk of heritable disease from common pelvis radiotherapy of male patients in Iran. In this work, the relation between TD and changes in beam energy, pelvis size, source to skin distance (SSD) and beam directions (anterior or posterior) were also evaluated. The values of TDs were measured on 67 randomly selected male patients during common pelvis radiotherapy using 1.17 and 1.33 MeV, Theratron Cobalt-60 unit at SSD of 80 cm and 9 MV, Neptun 10 PC and 18 MV, GE Saturne 20 at SSD of 100 cm at Seyed-Al Shohada Hospital, Isfahan, Iran. Results showed that the maximum TD was up to 12% of the tumor dose. Considering the risk factor for radiation-induced heritable disorders of 0.1% per Sv, an excess risk of hereditary disorders of 72 per 10000 births was conservatively calculated. There was a significant difference in the measured TD using different treatment machines and energies (P < 0.001). The TD at 100 cm SSD were much less than that for 80 cm SSD (P <0.001). The Pearson Correlation test showed that, as expected, there was a strong correlation between TD and patient’s pelvis size (r = 0.275, P <0.001). Using the student’s t-tests, it was found that, there was not a significant difference between TD and beam direction (P = 0.231). Iranian male patients undergoing pelvic radiotherapy have the potential of receiving a TD of more than 1 Gy which might result in temporary azoospermia. The risk for induction of hereditary disorders in future generations should be considered as low but not negligible in comparison with the correspondent nominal risk. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pelvis%20radiotherapy" title="pelvis radiotherapy">pelvis radiotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=testicular%20dose" title=" testicular dose"> testicular dose</a>, <a href="https://publications.waset.org/abstracts/search?q=infertility" title=" infertility"> infertility</a>, <a href="https://publications.waset.org/abstracts/search?q=hereditary%20effects" title=" hereditary effects"> hereditary effects</a> </p> <a href="https://publications.waset.org/abstracts/10918/testicular-dose-and-associated-risk-from-common-pelvis-radiation-therapy-in-iran" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10918.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">545</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2147</span> Assessment of Reproductive Toxicity of Diazinon Pesticide in Male Wistar Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Alfaifi">Mohammad Alfaifi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Organophosphates are among the most widely used synthetic insect pesticides. The widespread use of organophosphates has stimulated research into the possible existence of effects related with their reproductive toxic activity. The present study aimed to assess the effects of diazinon (DIZ) on male reproductive system. DIZ at the dose levels of 1.5, 3.0 and 9.0 mg/kg b. wt./day was administered orally to male rats of Wistar strain for 30 days to evaluate the toxic alterations in testicular histology, biochemistry, sperm dynamics, and testosterone levels. The body weight of animals did not show any significant changes, however, a significant reduction was observed in testes weight. DIZ also brought about marked reduction in epididymal and testicular sperm counts in exposed males and a decrease in serum testosterone concentration. Histopathological examination of testes showed mild to severe degenerative changes in seminiferous tubules at various dose levels. Fertility test showed 79% negative results. All these toxic effects are moderate at low doses and become severe at higher dose levels. From the results of the present study it is concluded that DIZ induces severe testicular damage and results in reduction in sperm count and thus affect fertility. Small changes in sperm counts are known to have adverse affects on human fertility. Therefore, application of such insecticide should be limited to a designed programme. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=reproductive%20toxicity" title="reproductive toxicity">reproductive toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=fertility" title=" fertility"> fertility</a>, <a href="https://publications.waset.org/abstracts/search?q=diazinon" title=" diazinon"> diazinon</a>, <a href="https://publications.waset.org/abstracts/search?q=sperm%20count" title=" sperm count"> sperm count</a> </p> <a href="https://publications.waset.org/abstracts/15763/assessment-of-reproductive-toxicity-of-diazinon-pesticide-in-male-wistar-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15763.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">318</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2146</span> Evaluation of Reproductive Toxicity of Diazinon Pesticide in Male Wistar Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Alfaifi">Mohammad Alfaifi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Alshehri"> Mohammed Alshehri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Organophosphates are among the most widely used synthetic insect pesticides. The widespread use of organophosphates has stimulated research into the possible existence of effects related with their reproductive toxic activity. The present study aimed to assess the effects of diazinon (DIZ) on male reproductive system. DIZ at the dose levels of 1.5, 3.0 and 9.0 mg/kg b. wt./day was administered orally to male rats of Wistar strain for 30 days to evaluate the toxic alterations in testicular histology, biochemistry, sperm dynamics and testosterone levels. The body weight of animals did not show any significant changes; however, a significant reduction was observed in testes weight. DIZ also brought about a marked reduction in epididymal and testicular sperm counts in exposed males and a decrease in serum testosterone concentration. Histopathological examination of testes showed mild to severe degenerative changes in seminiferous tubules at various dose levels. Fertility test showed 79% negative results. All these toxic effects are moderate at low doses and become severe at higher dose levels. From the results of the present study, it is concluded that DIZ induces severe testicular damage and results in a reduction in sperm count and thus affect fertility. Small changes in sperm counts are known to have adverse effects on human fertility. Therefore, application of such insecticide should be limited to a designed programme. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=organophosphates" title="organophosphates">organophosphates</a>, <a href="https://publications.waset.org/abstracts/search?q=reproductive%20toxicity" title=" reproductive toxicity"> reproductive toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=diazinon" title=" diazinon"> diazinon</a>, <a href="https://publications.waset.org/abstracts/search?q=fertility" title=" fertility"> fertility</a> </p> <a href="https://publications.waset.org/abstracts/26063/evaluation-of-reproductive-toxicity-of-diazinon-pesticide-in-male-wistar-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26063.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">410</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2145</span> Mobile Health Approaches in the Management of Breast Cancer: A Qualitative Content Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hyekyung%20Woo">Hyekyung Woo</a>, <a href="https://publications.waset.org/abstracts/search?q=Gwihyun%20Kim"> Gwihyun Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> mHealth, which encompasses mobile health technologies and interventions, is rapidly evolving in various medical specialties, and its impact is evident in oncology. This review describes current trends in research addressing the integration of mHealth into the management of breast cancer by examining evaluations of mHealth and its contributions across the cancer care continuum. Mobile technologies are perceived as effective in prevention and as feasible for managing breast cancer, but the diagnostic accuracy of these tools remains in doubt. Not all phases of breast cancer treatment involve mHealth, and not all have been addressed by research. These drawbacks in the application of mHealth to breast cancer management call for intensified research to strengthen its role in breast cancer care. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mobile%20application" title="mobile application">mobile application</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=content%20analysis" title=" content analysis"> content analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=mHealth" title=" mHealth"> mHealth</a> </p> <a href="https://publications.waset.org/abstracts/78172/mobile-health-approaches-in-the-management-of-breast-cancer-a-qualitative-content-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78172.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">312</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2144</span> Hyaluronic Acid - Alginate Hydrogel for the Transdifferentiation of Testis Cells into Erythrocyte and Hepatocyte-like Cells; A Practice Within an Effective Agent Choice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Leila%20Rashki%20Ghaleno">Leila Rashki Ghaleno</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamad%20Amin%20Hajari"> Mohamad Amin Hajari</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Montazeri"> Leila Montazeri</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdolhossein%20Shahverdi"> Abdolhossein Shahverdi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mojtaba%20Rezazadeh%20Valojerdi"> Mojtaba Rezazadeh Valojerdi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Spermatogonia stem cells (SSCs) exhibit pluripotency, enabling them to undergo differentiation into many cell lineages, including neurons, glia, endothelial cells, and hepatocytes when cultured in vitro. Although the specific mechanisms are not yet fully understood, it has been observed that biopolymer agents, such as hyaluronic acid (HA) and alginate (Alg), have the potential to induce transdifferentiation of SSCs. The current work aimed to examine the process of in vitro spermatogenesis and the conversion of mouse testicular cells into hepatocytes and erythrocyte-like cells utilizing the HA-Alg hydrogel. Method: After being extracted from the testes of a 5-day postpartum mouse (5 DPP), the testicular cells were separated into two enzymatic stages and then put into a composite hydrogel containing 0.5% HA and 1% alginate. On days 14 and 28 of culture, the colonies' growth, the cells' viability, and their histology were assessed. Result: Despite observing significant cell proliferation on day 14 and the development of circular-shaped organoids on day 28, it was noted that the organoids generated in the HA-Alg medium tended to maintain their circular morphology on day 28. Notably, the testicular cells underwent transdifferentiation into cell types resembling erythrocytes and hepatocytes. The hepatocyte-like cells exhibited the presence of glycogen and lipid deposits, indicating their hepatocyte-like characteristics. Interestingly, immunostaining analysis revealed the secretion of albumin and the presence of VEGFR on day 14. However, on day 28, albumin expression was not detected, while the expression of Sox9 (a marker for hepatocytes), Vegf, CD34, and C-kit (markers for erythrocytes) showed increased levels in the gene expression evaluation. Conclusion: The present findings indicated that HA-Alg could be a potent and effective agent for the transdifferentiation of testis cells into erythrocyte and hepatocyte-like cells, as recent studies have confirmed the transformation of SSCs into hepatocyte cells during in vitro culture. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20culture" title="3D culture">3D culture</a>, <a href="https://publications.waset.org/abstracts/search?q=mouse%20testicular%20cell" title=" mouse testicular cell"> mouse testicular cell</a>, <a href="https://publications.waset.org/abstracts/search?q=hyaluronic%20acid" title=" hyaluronic acid"> hyaluronic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20organoids" title=" liver organoids"> liver organoids</a> </p> <a href="https://publications.waset.org/abstracts/171962/hyaluronic-acid-alginate-hydrogel-for-the-transdifferentiation-of-testis-cells-into-erythrocyte-and-hepatocyte-like-cells-a-practice-within-an-effective-agent-choice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171962.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">71</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2143</span> Effect of Visnagin on Altered Steroidogenesis and Spermatogenesis, and Testicular Injury Induced by the Heavy Metal Lead</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saleh%20N.%20Maodaa">Saleh N. Maodaa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Lead (Pb) is an environmental pollutant causing serious health problems, including impairment of reproduction. Visnagin (VIS) is a furanochromone with promising antioxidant and anti-inflammatory effects; however, its protective efficacy against Pb toxicity has not been investigated. Objective: This study evaluated the protective effect of VIS on Pb reproductive toxicity, impaired steroidogenesis and spermatogenesis, oxidative stress and inflammation. Methods: Rats received VIS (30 or 60 mg/kg) and 50 mg/kg lead acetate for 3 weeks, and blood and testes samples were collected. Results: Pb intoxication impaired the pituitary-testicular axis (PTA), manifested by the decreased serum levels of gonadotropins and testosterone. Pb decreased sperm count, motility and viability, increased sperm abnormalities, and downregulated the steroidogenesis markers StAR, CYP17A1, 3β-HSD and 17β-HSD in the testis of rats. VIS significantly increased serum gonadotropins and testosterone, alleviated sperm parameters and upregulated steroidogenesis. In addition, VIS decreased pro-inflammatory cytokines, testicular lipid peroxidation and DNA fragmentation, downregulated Bax, and enhanced antioxidants and Bcl-2 Conclusion: These results demonstrate the protective effect of VIS against Pb reproductive toxicity in rats. VIS improved serum gonadotropins and testosterone, enhanced steroidogenesis and spermatogenesis, and attenuated oxidative injury, inflammation and apoptosis. Therefore, VIS is a promising candidate for the protection against Pb-induced reproduction impairment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pituitary-gonadal%20axis" title="pituitary-gonadal axis">pituitary-gonadal axis</a>, <a href="https://publications.waset.org/abstracts/search?q=cytokines" title=" cytokines"> cytokines</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20damage" title=" DNA damage"> DNA damage</a>, <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title=" apoptosis"> apoptosis</a> </p> <a href="https://publications.waset.org/abstracts/164996/effect-of-visnagin-on-altered-steroidogenesis-and-spermatogenesis-and-testicular-injury-induced-by-the-heavy-metal-lead" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/164996.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">98</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2142</span> Metastasis of Breast Cancer to the Lungs: Implications of Molecular Biology and Treatment Options</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fakhrosadat%20Sajjadian">Fakhrosadat Sajjadian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The majority of deaths in cancer patients are caused by distant metastasis. Breast cancer shows a unique spread pattern, often affecting bone, liver, lung, and brain. Breast cancer can be categorized into various subtypes according to gene expression patterns, and these subtypes exhibit specific preferences for organs where metastasis occurs. Breast tumors with luminal characteristics have a preference for spreading to the bone, whereas basal-like breast cancer (BLBC) shows a tendency to metastasize to the lungs. Still, the mechanisms behind this particular pattern of metastasis in organs have yet to be fully understood. In this evaluation, we will outline the latest progress in molecular signaling pathways and treatment methods for breast cancer lung metastasis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lung%20cancer" title="lung cancer">lung cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20cancer" title=" liver cancer"> liver cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=BLBC" title=" BLBC"> BLBC</a>, <a href="https://publications.waset.org/abstracts/search?q=metastasis" title=" metastasis"> metastasis</a> </p> <a href="https://publications.waset.org/abstracts/185132/metastasis-of-breast-cancer-to-the-lungs-implications-of-molecular-biology-and-treatment-options" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/185132.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">48</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2141</span> Association of Overweight and Obesity with Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amir%20Ghasemlouei">Amir Ghasemlouei</a>, <a href="https://publications.waset.org/abstracts/search?q=Alireza%20Khalaj"> Alireza Khalaj</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In women, cancer of the breast is one of the most common incident cancer and cause of death from cancer .we reviewed the prevalence of obesity and its association with breast cancer. In this study, a total of 25 articles regarding the subject matter of the article have been presented in which 640 patients were examined that 320 patients with breast cancer and 320 were controls. The distribution of breast cancer patients and controls with respect to their anthropometric indices in patients with higher weight, which was statistically significant (60.2 ± 10.2 kg) compared with control group (56.1 ± 11.3 kg). The body mass index of patients was (26.06+/-3.42) and significantly higher than the control group (24.1+/-1.7). Obesity leads to increased levels of adipose tissue in the body that can be stored toxins and carcinogens to produce a continuous supply. Due to the high level of fat and the role of estrogen in a woman is endogenous estrogen of the tumor and regulate the activities of growth steroids, obesity is a risk factor for breast cancer is confirmed. Our study and other studies show that obesity is a risk factor for breast cancer. And with a weight loss intervention for breast cancer can be prevented in the future. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=review%20study" title=" review study"> review study</a>, <a href="https://publications.waset.org/abstracts/search?q=obesity" title=" obesity"> obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=overweight" title=" overweight"> overweight</a> </p> <a href="https://publications.waset.org/abstracts/16945/association-of-overweight-and-obesity-with-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16945.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2140</span> Magnetic Nanoparticles for Cancer Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sachinkumar%20Patil">Sachinkumar Patil</a>, <a href="https://publications.waset.org/abstracts/search?q=Sonali%20Patil"> Sonali Patil</a>, <a href="https://publications.waset.org/abstracts/search?q=Shitalkumar%20Patil"> Shitalkumar Patil</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticles played important role in the biomedicine. New advanced methods having great potential apllication in the diagnosis and therapy of cancer. Now a day’s magnetic nanoparticles used in cancer therapy. Cancer is the major disease causes death. Magnetic nanoparticles show response to the magnetic field on the basis of this property they are used in cancer therapy. Cancer treated with hyperthermia by using magnetic nanoparticles it is unconventional but more safe and effective method. Magnetic nanoparticles prepared by using different innovative techniques that makes particles in uniform size and desired effect. Magnetic nanoparticles already used as contrast media in magnetic resonance imaging. A magnetic nanoparticle has been great potential application in cancer diagnosis and treatment as well as in gene therapy. In this review we will discuss the progress in cancer therapy based on magnetic nanoparticles, mainly including magnetic hyperthermia, synthesis and characterization of magnetic nanoparticles, mechanism of magnetic nanoparticles and application of magnetic nanoparticles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=magnetic%20nanoparticles" title="magnetic nanoparticles">magnetic nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=synthesis" title=" synthesis"> synthesis</a>, <a href="https://publications.waset.org/abstracts/search?q=characterization" title=" characterization"> characterization</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20therapy" title=" cancer therapy"> cancer therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperthermia" title=" hyperthermia"> hyperthermia</a>, <a href="https://publications.waset.org/abstracts/search?q=application" title=" application"> application</a> </p> <a href="https://publications.waset.org/abstracts/31421/magnetic-nanoparticles-for-cancer-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31421.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">639</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2139</span> An Extraction of Cancer Region from MR Images Using Fuzzy Clustering Means and Morphological Operations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ramandeep%20Kaur">Ramandeep Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Gurjit%20Singh%20Bhathal"> Gurjit Singh Bhathal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cancer diagnosis is very difficult task. Magnetic resonance imaging (MRI) scan is used to produce image of any part of the body and provides an efficient way for diagnosis of cancer or tumor. In existing method, fuzzy clustering mean (FCM) is used for the diagnosis of the tumor. In the proposed method FCM is used to diagnose the cancer of the foot. FCM finds the centroids of the clusters of the foot cancer obtained from MRI images. FCM thresholding result shows the extract region of the cancer. Morphological operations are applied to get extracted region of cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=magnetic%20resonance%20imaging%20%28MRI%29" title="magnetic resonance imaging (MRI)">magnetic resonance imaging (MRI)</a>, <a href="https://publications.waset.org/abstracts/search?q=fuzzy%20C%20mean%20clustering" title=" fuzzy C mean clustering"> fuzzy C mean clustering</a>, <a href="https://publications.waset.org/abstracts/search?q=segmentation" title=" segmentation"> segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=morphological%20operations" title=" morphological operations"> morphological operations</a> </p> <a href="https://publications.waset.org/abstracts/5937/an-extraction-of-cancer-region-from-mr-images-using-fuzzy-clustering-means-and-morphological-operations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/5937.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">398</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2138</span> Lived Experience of Breast Cancer for Arab Muslim Women </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nesreen%20M.%20Alqaissi">Nesreen M. Alqaissi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Little is known about the lived experiences of breast cancer among Arab Muslim women. The researcher used a qualitative interpretive phenomenological research design to explore the lived experiences of breast cancer as described by Jordanian Muslim women. A purposive sample of 20 women with breast cancer was recruited. Data were collected utilizing individual semi-structured interviews, and analyzed using Heideggerian Hermeneutical methodology. Results: Five related themes and one constitutive pattern: (a) breast cancer means death; (b) matriarchal family members as important source of support; (c) spirituality as a way to live and survive breast cancer; (d) concealing cancer experiences to protect self and families; (e) physicians as protectors and treatment decision makers; (f) the constitutive pattern: culture influencing Jordanian women experiences with breast cancer. In conclusion, researchers and healthcare providers should consider the influence of culture, spirituality, and families, when caring for women with breast cancer from Jordan. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=Arab%20Muslim" title=" Arab Muslim"> Arab Muslim</a>, <a href="https://publications.waset.org/abstracts/search?q=Jordan" title=" Jordan"> Jordan</a>, <a href="https://publications.waset.org/abstracts/search?q=lived%20experiences" title=" lived experiences"> lived experiences</a>, <a href="https://publications.waset.org/abstracts/search?q=spirituality" title=" spirituality"> spirituality</a>, <a href="https://publications.waset.org/abstracts/search?q=culture" title=" culture "> culture </a> </p> <a href="https://publications.waset.org/abstracts/14317/lived-experience-of-breast-cancer-for-arab-muslim-women" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14317.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">514</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=testicular%20cancer&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=testicular%20cancer&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=testicular%20cancer&page=4">4</a></li> <li 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