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<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE html> <html lang="en" dir="ltr" version="HTML+RDFa+MathML 1.1" xmlns:dc="http://purl.org/dc/terms/" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:og="http://ogp.me/ns#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#" xmlns:sioct="http://rdfs.org/sioc/types#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:mml="http://www.w3.org/1998/Math/MathML"> <head profile="http://www.w3.org/1999/xhtml/vocab">  <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <script>window.dataLayer = window.dataLayer || [];window.dataLayer.push({"page":{"hwTitle":"Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting: Taking Endometrial Cancer Trials Into the Translational Era","hwUrl":"https://ijgc.bmj.com/content/23/8/1528","hwPath":"/content/23/8/1528","hwType":"journal page"},"user":{"hwMemberID":"","hwLoggedIntoInstitutionID":"","hwLoggedIntoInstitution":"","hwAccessUsageTerms":"guest","hwRegisteredUser":"no","hwHasFullTextAccess":"no","hwEntitled":"no","mail":"e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855"},"content":{"hwIssueDate":"2013-10-01","hwIssueDateTime":"2013-10-01 00:00:00","hwPublicationDate":"2019-02-26","hwPublicationDateTime":"2019-02-26 16:18:32","hwNlmArticleType":"research-article","hwDOI":"10.1097/IGC.0b013e3182a26edb","hwAuthors":"Carien L. Creutzberg,Henry C. Kitchener,Michael J. Birrer,Fabio Landoni,Karen H. Lu,Melanie Powell,Carol Aghajanian,Richard Edmondson,Paul J. Goodfellow,Michael Quinn,Helga B. 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The aims were to review recent advances in molecular pathology of endometrial cancer, focusing on molecular-based therapy, and to identify key hypotheses and issues to be addressed through international collaborative clinical trials. Methods Reviews and summaries of current knowledge were presented followed by parallel working group sessions for surgery, adjuvant and systemic therapy, and translational research. Plenary discussions were held to integrate translational and clinical issues, and a final discussion session to agree on key trial concepts. Results and Conclusions Proposals to take forward on the following trials were agreed: (1) lymphadenectomy to direct adjuvant treatment in women with high-risk endometrial cancer, including a sentinel node substudy; (2) conservative therapy for low-risk endometrial cancers in morbidly obese women with high surgical risks and for fertility-sparing treatment in premenopausal patients; (3) adjuvant therapy for women with early-stage carcinosarcoma. A proposal was made that a GCIG Early Phase Consortium be developed to serve as an international platform for rapid assessment of biomarkers." /> <meta name="DC.Contributor" content="Carien L. Creutzberg" /> <meta name="DC.Contributor" content="Henry C. Kitchener" /> <meta name="DC.Contributor" content="Michael J. Birrer" /> <meta name="DC.Contributor" content="Fabio Landoni" /> <meta name="DC.Contributor" content="Karen H. Lu" /> <meta name="DC.Contributor" content="Melanie Powell" /> <meta name="DC.Contributor" content="Carol Aghajanian" /> <meta name="DC.Contributor" content="Richard Edmondson" /> <meta name="DC.Contributor" content="Paul J. Goodfellow" /> <meta name="DC.Contributor" content="Michael Quinn" /> <meta name="DC.Contributor" content="Helga B. Salvesen" /> <meta name="DC.Contributor" content="Gillian Thomas" /> <meta name="article:published_time" content="2013-10-01" /> <meta name="article:section" content="Cooperative Groups" /> <meta name="citation_title" content="Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting: Taking Endometrial Cancer Trials Into the Translational Era" /> <meta name="citation_abstract" lang="en" content="<h3>Objective</h3> <p>The second Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting was held on December 1, 2012, and included international multidisciplinary representatives of the 24 member groups. The aims were to review recent advances in molecular pathology of endometrial cancer, focusing on molecular-based therapy, and to identify key hypotheses and issues to be addressed through international collaborative clinical trials.</p><h3>Methods</h3> <p>Reviews and summaries of current knowledge were presented followed by parallel working group sessions for surgery, adjuvant and systemic therapy, and translational research. Plenary discussions were held to integrate translational and clinical issues, and a final discussion session to agree on key trial concepts.</p><h3>Results and Conclusions</h3> <p>Proposals to take forward on the following trials were agreed: (1) lymphadenectomy to direct adjuvant treatment in women with high-risk endometrial cancer, including a sentinel node substudy; (2) conservative therapy for low-risk endometrial cancers in morbidly obese women with high surgical risks and for fertility-sparing treatment in premenopausal patients; (3) adjuvant therapy for women with early-stage carcinosarcoma. A proposal was made that a GCIG Early Phase Consortium be developed to serve as an international platform for rapid assessment of biomarkers.</p>" /> <meta name="citation_journal_title" content="International Journal of Gynecologic Cancer" /> <meta name="citation_publisher" content="BMJ Specialist Journals" /> <meta name="citation_publication_date" content="2013/10/01" /> <meta name="citation_mjid" content="ijgc;23/8/1528" /> <meta name="citation_id" content="23/8/1528" /> <meta name="citation_public_url" content="https://ijgc.bmj.com/content/23/8/1528" /> <meta name="citation_abstract_html_url" content="https://ijgc.bmj.com/content/23/8/1528.abstract" /> <meta name="citation_full_html_url" content="https://ijgc.bmj.com/content/23/8/1528.full" /> <meta name="citation_pdf_url" content="https://ijgc.bmj.com/content/ijgc/23/8/1528.full.pdf" /> <meta name="citation_issn" content="1048-891X" /> <meta name="citation_issn" content="1525-1438" /> <meta name="citation_doi" content="10.1097/IGC.0b013e3182a26edb" /> <meta name="citation_pmid" content="24257568" /> <meta name="citation_volume" content="23" /> <meta name="citation_issue" content="8" /> <meta name="citation_article_type" content="Research Article" /> <meta name="citation_section" content="Cooperative Groups" /> <meta name="citation_author" content="Carien L. Creutzberg" /> <meta name="citation_author_institution" content="Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands;" /> <meta name="citation_author" content="Henry C. Kitchener" /> <meta name="citation_author_institution" content="Institute of Cancer Sciences, University of Manchester, United Kingdom;" /> <meta name="citation_author" content="Michael J. Birrer" /> <meta name="citation_author_institution" content="Division of Hematology and Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA;" /> <meta name="citation_author" content="Fabio Landoni" /> <meta name="citation_author_institution" content="Division of Gynaecology, European Institute of Oncology, Milan, Italy;" /> <meta name="citation_author" content="Karen H. Lu" /> <meta name="citation_author_institution" content="Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center, Houston, TX;" /> <meta name="citation_author" content="Melanie Powell" /> <meta name="citation_author_institution" content="Department of Clinical Oncology, Barts Health NHS Trust, London, United Kingdom;" /> <meta name="citation_author" content="Carol Aghajanian" /> <meta name="citation_author_institution" content="Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY;" /> <meta name="citation_author" content="Richard Edmondson" /> <meta name="citation_author_institution" content="Department of Gynaecology, Newcastle University and Northern Institute for Cancer Research, Newcastle upon Tyne, United Kingdom;" /> <meta name="citation_author" content="Paul J. Goodfellow" /> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, College of Medicine, Ohio State University, Columbus, OH;" /> <meta name="citation_author" content="Michael Quinn" /> <meta name="citation_author_institution" content="Department of Gynaecologic Oncology, Royal Women’s Hospital, and Melbourne University Dept of Obstetrics and Gynaecology, Australia;" /> <meta name="citation_author" content="Helga B. Salvesen" /> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, Haukeland University Hospital; and Department of Clinical Medicine, University of Bergen, Norway; and" /> <meta name="citation_author" content="Gillian Thomas" /> <meta name="citation_author_institution" content="Department of Radiation Oncology, Sunnybrook Cancer Center, Toronto, Canada." /> <meta name="twitter:title" content="Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting: Taking Endometrial Cancer Trials Into the Translational Era" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:image" content="https://ijgc.bmj.com/pages/wp-content/uploads/sites/73/2019/07/ijgc-social-media-card.jpg" /> <meta name="twitter:description" content="Objective The second Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting was held on December 1, 2012, and included international multidisciplinary representatives of the 24 member groups. The aims were to review recent advances in molecular pathology of endometrial cancer, focusing on molecular-based therapy, and to identify key hypotheses and issues to be addressed through international collaborative clinical trials. Methods Reviews and summaries of current knowledge were presented followed by parallel working group sessions for surgery, adjuvant and systemic therapy, and translational research. Plenary discussions were held to integrate translational and clinical issues, and a final discussion session to agree on key trial concepts. Results and Conclusions Proposals to take forward on the following trials were agreed: (1) lymphadenectomy to direct adjuvant treatment in women with high-risk endometrial cancer, including a sentinel node substudy; (2) conservative therapy for low-risk endometrial cancers in morbidly obese women with high surgical risks and for fertility-sparing treatment in premenopausal patients; (3) adjuvant therapy for women with early-stage carcinosarcoma. A proposal was made that a GCIG Early Phase Consortium be developed to serve as an international platform for rapid assessment of biomarkers." /> <meta name="og-title" property="og:title" content="Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting: Taking Endometrial Cancer Trials Into the Translational Era" /> <meta name="og-url" property="og:url" content="https://ijgc.bmj.com/content/23/8/1528" /> <meta name="og-site-name" property="og:site_name" content="International Journal of Gynecologic Cancer" /> <meta name="og-description" property="og:description" content="Objective The second Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting was held on December 1, 2012, and included international multidisciplinary representatives of the 24 member groups. The aims were to review recent advances in molecular pathology of endometrial cancer, focusing on molecular-based therapy, and to identify key hypotheses and issues to be addressed through international collaborative clinical trials. Methods Reviews and summaries of current knowledge were presented followed by parallel working group sessions for surgery, adjuvant and systemic therapy, and translational research. Plenary discussions were held to integrate translational and clinical issues, and a final discussion session to agree on key trial concepts. Results and Conclusions Proposals to take forward on the following trials were agreed: (1) lymphadenectomy to direct adjuvant treatment in women with high-risk endometrial cancer, including a sentinel node substudy; (2) conservative therapy for low-risk endometrial cancers in morbidly obese women with high surgical risks and for fertility-sparing treatment in premenopausal patients; (3) adjuvant therapy for women with early-stage carcinosarcoma. A proposal was made that a GCIG Early Phase Consortium be developed to serve as an international platform for rapid assessment of biomarkers." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://ijgc.bmj.com/pages/wp-content/uploads/sites/73/2019/07/ijgc-social-media-card.jpg" /> <title>Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting: Taking Endometrial Cancer Trials Into the Translational Era | International Journal of Gynecologic Cancer</title> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__zEtNwUu9MaBwPq3JhYABsUEb8zJetUS42Q04qTPWDcc__wUr2GCCXq5CGuNFk2jmV52iytGLjUd7dn7guJp7QOB0__RDn7aIfjZIdXcl7wVtBcJLKS2b-1gFRdOHlwuadkoAo.css" media="all" /> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__gzhCDL7s2DdMqxGYgWxUMcRJhFfthtVcV5dQFZdV090__yAkxBLUKwF6cHyMzviVeuMUXsvTJC8gS_7UFjY1cM_0__RDn7aIfjZIdXcl7wVtBcJLKS2b-1gFRdOHlwuadkoAo.css" media="all" /> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__s27kGxLMTJcJhg1XDW_9_0Dhn7ft1W-e4jlOnyd7SEo__sXFYuF13EFhuf6XoVwDz0s9rF7BBCr1PbIj-xDo_9vQ__RDn7aIfjZIdXcl7wVtBcJLKS2b-1gFRdOHlwuadkoAo.css" media="all" /> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__XtKusGPLgBKze5RrpZONUSz8F7DuR8EluPkJ4fbdQA4__ndhN8J2Jh8vzutPoTD8e6WYLEOj7xd-3bf1clgdpI8g__RDn7aIfjZIdXcl7wVtBcJLKS2b-1gFRdOHlwuadkoAo.css" media="all" /> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__nM3zSVn8CuB8A94bYOeBMLHDCeibEPsjsW1Doxu5_Xk__WcSYsek5AmWdrYBEq5QSHiOY7a_XCh1A_j0efkZ26FQ__RDn7aIfjZIdXcl7wVtBcJLKS2b-1gFRdOHlwuadkoAo.css" media="all" /> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__-BkZ71IF4pBXmZfP4vYyswWdIhuaKktrUUQ4i2vtUVo__0i_0YcYkMECNn0z7FdhNoJ8gLWleqnTtjnHRAmLijvc__RDn7aIfjZIdXcl7wVtBcJLKS2b-1gFRdOHlwuadkoAo.css" media="all" />  <script src="https://cookie-cdn.cookiepro.com/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="565e50dd-f6e9-46d6-91cd-5c40a270264f"></script> <script type="text/javascript"> function OnetrustAdsConsent(){ if(googletag.apiReady){ //console.log("GoogleTag API ready") googletag.pubads().disableInitialLoad(); 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/><strong>PDF</strong></a></a> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-highwire-article-cat article-category col-narrow-9 col-normal-10" > <div class="pane-content"> <div class="field field-name-field-highwire-article-cat field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Cooperative Groups</div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-article-citation col-mobile-10 col-narrow-10 col-normal-11 article-title" > <div class="pane-content"> <div class="highwire-article-citation highwire-citation-type-highwire-article node3373" data-node-nid="3373" id="node-3373--21975388101" data-pisa="ijgc;23/8/1528" data-pisa-master="ijgc;10.1097/IGC.0b013e3182a26edb" data-apath="/ijgc/23/8/1528.atom"><cite class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-title clearfix"> <div class="highwire-cite-title">Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting: Taking Endometrial Cancer Trials Into the Translational Era</div> <span class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="ijgc;10.1097/IGC.0b013e3182a26edb" data-atom-uri="/ijgc/23/8/1528.atom" data-request-view="full"></span></span> </cite> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-panel-tabs-container col-narrow-12 clear" > <div class="pane-content"> <div data-panels-ajax-tab-preloaded="jnl_template_bmjj_tab_art" id="panels-ajax-tab-container-highwire_article_tabs" class="panels-ajax-tab-container"><div class="panels-ajax-tab-loading" style ="display:none"><img class="loading" src="https://ijgc.bmj.com/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif" alt="Loading" title="Loading" /></div><div class="panels-ajax-tab-wrap-jnl_template_bmjj_tab_art"><div class="panel-display panel-1col clearfix" > <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-markup author-affiliates col-narrow-12 author-affiliates-corresp article" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Carien L. Creutzberg</span><span class="contrib-degrees">, MD, PhD</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">*</a>, </li><li class="contributor" id="contrib-2"><span class="name">Henry C. Kitchener</span><span class="contrib-degrees">, MD</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">†</a>, </li><li class="contributor" id="contrib-3"><span class="name">Michael J. Birrer</span><span class="contrib-degrees">, MD, PhD</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">‡</a>, </li><li class="contributor" id="contrib-4"><span class="name">Fabio Landoni</span><span class="contrib-degrees">, MD</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">§</a>, </li><li class="contributor" id="contrib-5"><span class="name">Karen H. Lu</span><span class="contrib-degrees">, MD</span><a id="xref-aff-5-1" class="xref-aff" href="#aff-5">∥</a>, </li><li class="contributor" id="contrib-6"><span class="name">Melanie Powell</span><span class="contrib-degrees">, MD</span><a id="xref-aff-6-1" class="xref-aff" href="#aff-6">¶</a>, </li><li class="contributor" id="contrib-7"><span class="name">Carol Aghajanian</span><span class="contrib-degrees">, MD</span><a id="xref-aff-7-1" class="xref-aff" href="#aff-7">#</a>, </li><li class="contributor" id="contrib-8"><span class="name">Richard Edmondson</span><span class="contrib-degrees">, MD</span><a id="xref-aff-8-1" class="xref-aff" href="#aff-8">**</a>, </li><li class="contributor" id="contrib-9"><span class="name">Paul J. Goodfellow</span><span class="contrib-degrees">, PhD</span><a id="xref-aff-9-1" class="xref-aff" href="#aff-9">††</a>, </li><li class="contributor" id="contrib-10"><span class="name">Michael Quinn</span><span class="contrib-degrees">, MD</span><a id="xref-aff-10-1" class="xref-aff" href="#aff-10">‡‡</a>, </li><li class="contributor" id="contrib-11"><span class="name">Helga B. Salvesen</span><span class="contrib-degrees">, MD</span><a id="xref-aff-11-1" class="xref-aff" href="#aff-11">§§</a> and </li><li class="last" id="contrib-12"><span class="name">Gillian Thomas</span><span class="contrib-degrees">, MD</span><a id="xref-aff-12-1" class="xref-aff" href="#aff-12">∥∥</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>*</sup><span class="addr-line">Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands;</span></address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>†</sup><span class="addr-line">Institute of Cancer Sciences, University of Manchester, United Kingdom;</span></address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>‡</sup><span class="addr-line">Division of Hematology and Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA;</span></address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>§</sup><span class="addr-line">Division of Gynaecology, European Institute of Oncology, Milan, Italy;</span></address></li><li class="aff"><a id="aff-5" name="aff-5"></a><address><sup>∥</sup><span class="addr-line">Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center, Houston, TX;</span></address></li><li class="aff"><a id="aff-6" name="aff-6"></a><address><sup>¶</sup><span class="addr-line">Department of Clinical Oncology, Barts Health NHS Trust, London, United Kingdom;</span></address></li><li class="aff"><a id="aff-7" name="aff-7"></a><address><sup>#</sup><span class="addr-line">Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY;</span></address></li><li class="aff"><a id="aff-8" name="aff-8"></a><address><sup>**</sup><span class="addr-line">Department of Gynaecology, Newcastle University and Northern Institute for Cancer Research, Newcastle upon Tyne, United Kingdom;</span></address></li><li class="aff"><a id="aff-9" name="aff-9"></a><address><sup>††</sup><span class="addr-line">Department of Obstetrics and Gynecology, College of Medicine, Ohio State University, Columbus, OH;</span></address></li><li class="aff"><a id="aff-10" name="aff-10"></a><address><sup>‡‡</sup><span class="addr-line">Department of Gynaecologic Oncology, Royal Women’s Hospital, and Melbourne University Dept of Obstetrics and Gynaecology, Australia;</span></address></li><li class="aff"><a id="aff-11" name="aff-11"></a><address><sup>§§</sup><span class="addr-line">Department of Obstetrics and Gynecology, Haukeland University Hospital; and Department of Clinical Medicine, University of Bergen, Norway; and</span></address></li><li class="aff"><a id="aff-12" name="aff-12"></a><address><sup>∥∥</sup><span class="addr-line">Department of Radiation Oncology, Sunnybrook Cancer Center, Toronto, Canada.</span></address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Address correspondence and reprint requests to Carien L. Creutzberg, MD, PhD, Department of Clinical Oncology, Postzone K1-P, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: <a href="http://c.l.creutzberg@lumc.nl">c.l.creutzberg@lumc.nl</a>.</li></ol></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-markup abstract-with-bc" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" id="content-block" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view "><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><div id="sec-1" class="subsection"><p id="p-3"><strong>Objective</strong> The second Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Clinical Trials Planning Meeting was held on December 1, 2012, and included international multidisciplinary representatives of the 24 member groups. The aims were to review recent advances in molecular pathology of endometrial cancer, focusing on molecular-based therapy, and to identify key hypotheses and issues to be addressed through international collaborative clinical trials.</p></div><div id="sec-2" class="subsection"><p id="p-4"><strong>Methods</strong> Reviews and summaries of current knowledge were presented followed by parallel working group sessions for surgery, adjuvant and systemic therapy, and translational research. Plenary discussions were held to integrate translational and clinical issues, and a final discussion session to agree on key trial concepts.</p></div><div id="sec-3" class="subsection"><p id="p-5"><strong>Results and Conclusions</strong> Proposals to take forward on the following trials were agreed: (1) lymphadenectomy to direct adjuvant treatment in women with high-risk endometrial cancer, including a sentinel node substudy; (2) conservative therapy for low-risk endometrial cancers in morbidly obese women with high surgical risks and for fertility-sparing treatment in premenopausal patients; (3) adjuvant therapy for women with early-stage carcinosarcoma. 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