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data-track-label='10.1038/s41592-024-02445-w, Nature Methods, 1' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02445-w'>The dawn of an era</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Natalie Souza <a class="author-email" href="mailto:desouza@imsb.biol.ethz.ch"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>For <span class="EmphasisTypeItalic">Nature Methods’</span> 20th anniversary, our current and past editors reminisce about their favorite papers, initiatives and projects at the journal.</p> </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p><span>Techniques: </span>Transcriptomics</p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">858</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02445-w</div> <div class="image-search hiddenDesktop"> </div> <div class="image-search hiddenMobile"> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Research Highlight</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02423-2, Nature Methods, 2' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02423-2'>Biocomputation using tristate buffers</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Lin Tang <a class="author-email" href="mailto:Lin.tang@nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>Boolean logic gates are often considered the basic elements to construct more complex computational systems. When applying this approach to biocomputation in mammalian cells, a number of biological challenges, limit the level of achievable</p> <span class="read-more">… </div> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">272</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02423-2</div> <div class="image-search hiddenDesktop"> </div> <div class="image-search hiddenMobile"> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Feature</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02441-0, Nature Methods, 3' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02441-0'>From blobology to atomic resolution</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Allison Doerr <a class="author-email" href="mailto:a.doerr@us.nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>For <span class="EmphasisTypeItalic">Nature Methods’</span> 20th anniversary, our current and past editors reminisce about their favorite papers, initiatives and projects at the journal.</p> </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p><span>Techniques: </span>Cryo-EM, Cryo-electron Tomography</p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">772</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02441-0</div> <div class="image-search hiddenDesktop"> <a href="/articles/10.1038/s41592-024-02441-0" data-track-category="mosaic:search-page" data-track="click" data-track-action="snippetimage_interact" data-track-label="10.1038/s41592-024-02441-0" target="_blank"> <img src="https://media.springernature.com/w200/springer-static/image/art%3A10.1038%2Fs41592-024-02441-0/MediaObjects/41592_2024_2441_Figa_HTML.png" alt=""> </a> </div> <div class="image-search hiddenMobile"> <a href="/articles/10.1038/s41592-024-02441-0" data-track-category="mosaic:search-page" data-track="click" data-track-action="snippetimage_interact" data-track-label="10.1038/s41592-024-02441-0" target="_blank"> <img src="https://media.springernature.com/w200/springer-static/image/art%3A10.1038%2Fs41592-024-02441-0/MediaObjects/41592_2024_2441_Figa_HTML.png" alt=""> </a> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Research Highlight</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02510-4, Nature Methods, 4' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02510-4'>Fallopian tube assembloids</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Madhura Mukhopadhyay <a class="author-email" href="mailto:madhura.mukho@us.nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>Assembloids are next-generation organoids composed of spatially organized cell types in a 3D culture. These systems are highly complex and serve as accurate models to study the composition and function of an organ system. Although assembloids have</p> <span class="read-more">… </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p class="collapsed"> <span>Techniques: </span>Cell And Tissue Culture, 3D Cell Culture, Organoid Culture, Immunohistochemistry, Proteomics... <a class="more-link" href="#">2 more</a> </p> <p class="expanded hidden"> <span>Techniques: </span>Cell And Tissue Culture, 3D Cell Culture, Organoid Culture, Immunohistochemistry, Proteomics, TEM, Time Lapse Microscopy <a class="less-link" href="#">less</a> </p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">114</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02510-4</div> <div class="image-search hiddenDesktop"> </div> <div class="image-search hiddenMobile"> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Research Highlight</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02313-7, Nature Methods, 5' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02313-7'>Linking enhancers to genes</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Lin Tang <a class="author-email" href="mailto:Lin.tang@nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>Enhancers are one of the main players driving spatiotemporal gene expression patterns, and they could harbor genetic variants underlying complex traits and diseases. Despite being paramount to our understanding of gene regulation, “enhancer–gene maps</p> <span class="read-more">… </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p><span>Techniques: </span>Genome-Wide Association Study</p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">1,424</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02313-7</div> <div class="image-search hiddenDesktop"> </div> <div class="image-search hiddenMobile"> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Research Highlight</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02468-3, Nature Methods, 6' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02468-3'>Disentangling parallel processes with BEYOND</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Jean Nakhle <a class="author-email" href="mailto:jean.nakhle@nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>Age acts as a confounding variable for researchers attempting to differentiate between age-related alterations in the brain and pathological changes linked to Alzheimer’s disease (AD). A collaborative study led by Vilas Menon, David A. Bennett, Naomi</p> <span class="read-more">… </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p><span>Techniques: </span>RNA-seq, Machine Learning, Statistical Modeling</p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">182</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02468-3</div> <div class="image-search hiddenDesktop"> </div> <div class="image-search hiddenMobile"> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Research Highlight</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02192-y, Nature Methods, 7' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02192-y'>Development of the human head</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Nina Vogt <a class="author-email" href="mailto:nina.vogt@us.nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>Much of our knowledge about early human development dates back to data collected almost a century ago. “I’m still impressed by what was described at that time … it’s really amazing what they could see just with a basic microscope and</p> <span class="read-more">… </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p><span>Techniques: </span>Whole-mount Immunostaining, Tissue clearing, Light Sheet Microscopy</p> </div> </div> <div class="snippet-techniques"> <div class="models"> <p><span>Models: </span>Homo sapiens</p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">697</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02192-y</div> <div class="image-search hiddenDesktop"> <a href="/articles/10.1038/s41592-024-02192-y" data-track-category="mosaic:search-page" data-track="click" data-track-action="snippetimage_interact" data-track-label="10.1038/s41592-024-02192-y" target="_blank"> <img src="https://media.springernature.com/w200/springer-static/image/art%3A10.1038%2Fs41592-024-02192-y/MediaObjects/41592_2024_2192_Figa_HTML.png" alt=""> </a> </div> <div class="image-search hiddenMobile"> <a href="/articles/10.1038/s41592-024-02192-y" data-track-category="mosaic:search-page" data-track="click" data-track-action="snippetimage_interact" data-track-label="10.1038/s41592-024-02192-y" target="_blank"> <img src="https://media.springernature.com/w200/springer-static/image/art%3A10.1038%2Fs41592-024-02192-y/MediaObjects/41592_2024_2192_Figa_HTML.png" alt=""> </a> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Research Highlight</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02508-y, Nature Methods, 8' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02508-y'>A leap for mesoscale imaging</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Rita Strack <a class="author-email" href="mailto:rita.strack@us.nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>A computational mesoscale microscope offers large-scale volumetric imaging of intravital dynamics with cellular resolution.</p> </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p><span>Techniques: </span>Fluorescence Microscopy, Image Processing, Microscopy, Intravital Microscopy</p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">275</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02508-y</div> <div class="image-search hiddenDesktop"> <a href="/articles/10.1038/s41592-024-02508-y" data-track-category="mosaic:search-page" data-track="click" data-track-action="snippetimage_interact" data-track-label="10.1038/s41592-024-02508-y" target="_blank"> <img src="https://media.springernature.com/w200/springer-static/image/art%3A10.1038%2Fs41592-024-02508-y/MediaObjects/41592_2024_2508_Figa_HTML.png" alt=""> </a> </div> <div class="image-search hiddenMobile"> <a href="/articles/10.1038/s41592-024-02508-y" data-track-category="mosaic:search-page" data-track="click" data-track-action="snippetimage_interact" data-track-label="10.1038/s41592-024-02508-y" target="_blank"> <img src="https://media.springernature.com/w200/springer-static/image/art%3A10.1038%2Fs41592-024-02508-y/MediaObjects/41592_2024_2508_Figa_HTML.png" alt=""> </a> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Research Highlight</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02289-4, Nature Methods, 9' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02289-4'>Automated atomic modeling in cryo-EM maps</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Arunima Singh <a class="author-email" href="mailto:arunima.singh@us.nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>Cryo-electron microscopy (cryo-EM) has fast become an important and almost routine tool for high-resolution structure determination of biomolecules and biomolecular complexes. However, atomic model building in cryo-EM maps requires a high degree of</p> <span class="read-more">… </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p><span>Techniques: </span>Cryo-EM, Structure Determination</p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="views"> Downloads: <span class="green-text">877</span> </span> </div> <div class="version-video"> </div> </div> <div class="p_doi" hidden>10.1038/s41592-024-02289-4</div> <div class="image-search hiddenDesktop"> <a href="/articles/10.1038/s41592-024-02289-4" data-track-category="mosaic:search-page" data-track="click" data-track-action="snippetimage_interact" data-track-label="10.1038/s41592-024-02289-4" target="_blank"> <img src="https://media.springernature.com/w200/springer-static/image/art%3A10.1038%2Fs41592-024-02289-4/MediaObjects/41592_2024_2289_Figa_HTML.png" alt=""> </a> </div> <div class="image-search hiddenMobile"> <a href="/articles/10.1038/s41592-024-02289-4" data-track-category="mosaic:search-page" data-track="click" data-track-action="snippetimage_interact" data-track-label="10.1038/s41592-024-02289-4" target="_blank"> <img src="https://media.springernature.com/w200/springer-static/image/art%3A10.1038%2Fs41592-024-02289-4/MediaObjects/41592_2024_2289_Figa_HTML.png" alt=""> </a> </div> </div> </li> <li class="SN_search-Results__searched_content" data-track-component="search-result"> <div class="SN_search-Results__searched_content_list"> <div class="snippet_source"> <div class="snippet_top-right"><span class="content-type">Technology Feature</span></div> <div class="snippet_top-left"> <p> <span class="source italic">Nature Methods</span> <time datetime="" class="date-time"> (2024) </time> </p> </div> </div> <div class="snippet_source_details"> </div> <h3> <a class="title" target="_blank" rel="noopener" data-track="click" data-track-action="searchresult_interact" data-track-label='10.1038/s41592-024-02170-4, Nature Methods, 10' data-track-category='mosaic:search-page' href='https://www.nature.com/articles/s41592-024-02170-4'>Inside the chase after those elusive proteoforms</a> </h3> <div class="author-info"> <span class="authors"> <span class="author-name">Vivien Marx <a class="author-email" href="mailto:v.marx@us.nature.com"> <img class="author-email-icon" src="/assets/images/icons/email.png" alt="Email to Author"/> </a> </span> </span> </div> <div class="snippet"> <div> <div class="trimmedText"><p>Human cells contain crowds of protein variants, but, especially in a time of funding challenges, chasing these proteoforms takes dogged persistence.</p> </div> </div> </div> <div class="snippet-techniques"> <div class="techniques"> <p><span>Techniques: </span>Proteomics</p> </div> </div> <div class="snippet_bottom-left"> <div class="views-citations"> <span class="citation"> Citations: <span class="green-text">3</span> </span> <span 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