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xml:space="preserve"> <path d="M57.5,38.193l12.5,12.5l12.5-12.5l-2.5-2.5l-10,10l-10-10L57.5,38.193z"/> </svg></span><span class="menu-text">BIO Events</span></a></li></ul></div></nav></div></div> </div> </div> </div> </header> <div id="content" class="site-content"> <div class="ast-container"> <div id="primary" class="content-area primary"> <main id="main" class="site-main"> <article class="post-3253 post type-post status-publish format-standard has-post-thumbnail hentry category-bio-convention category-bio-member-think-tank category-health category-latest-news ast-article-single" id="post-3253" itemtype="https://schema.org/CreativeWork" itemscope="itemscope"> <div class="ast-post-format- single-layout-1 ast-no-date-box"> <header class="entry-header "> <h1 class="entry-title" itemprop="headline">BIO’s Emerging Start-Up Stadium winner: Paradox Immunotherapeutics</h1><div class="entry-meta"><span class="posted-on"><span class="published" itemprop="datePublished"> September 19, 2023 </span></span> / <span class="ast-terms-link"><a href="https://bio.news/category/bio-convention/" class="">BIO Events</a>, <a href="https://bio.news/category/bio-member-think-tank/" class="">BIO Member Think Tank</a>, <a href="https://bio.news/category/health/" class="">Health</a>, <a href="https://bio.news/category/latest-news/" class="">Latest News</a></span> / By <span class="posted-by vcard author" itemtype="https://schema.org/Person" itemscope="itemscope" itemprop="author"> <a title="View all posts by Colleen Pietras, M.D." href="https://bio.news/author/colleen-pietras/" rel="author" class="url fn n" itemprop="url" > <span class="author-name" itemprop="name" > Colleen Pietras, M.D. </span> </a> </span> </div><div class="post-thumb-img-content post-thumb"><img fetchpriority="high" width="1024" height="722" src="https://bio.news/wp-content/uploads/2023/09/paradoxbio-1024x722.jpg" class="attachment-large size-large wp-post-image" alt="start-up stadium" itemprop="image" decoding="async" srcset="https://bio.news/wp-content/uploads/2023/09/paradoxbio-1024x722.jpg 1024w, https://bio.news/wp-content/uploads/2023/09/paradoxbio-350x247.jpg 350w, https://bio.news/wp-content/uploads/2023/09/paradoxbio-768x541.jpg 768w, https://bio.news/wp-content/uploads/2023/09/paradoxbio-1536x1082.jpg 1536w, https://bio.news/wp-content/uploads/2023/09/paradoxbio-2048x1443.jpg 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></div> <div class="ast-post-social-sharing"> <div class="ast-social-inner-wrap element-social-inner-wrap social-show-label-true ast-social-color-type-custom"> <a href="https://www.facebook.com/sharer.php?u=https%3A%2F%2Fbio.news%2Fbio-convention%2Fbio-emerging-start-up-stadium-paradox-immunotherapeutics-biotech%2F" aria-label="Facebook" target="_blank" rel="noopener noreferrer" class="ast-inline-flex ast-social-icon-a"> <div style="--color: #557dbc; --background-color:transparent;" class="ast-social-element ast-facebook-social-item"> <span 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xmlns='http://www.w3.org/2000/svg' viewBox='0 0 24 24'><path d='M18.244 2.25H21.552L14.325 10.51L22.827 21.75H16.17L10.956 14.933L4.99 21.75H1.68L9.41 12.915L1.254 2.25H8.08L12.793 8.481L18.244 2.25ZM17.083 19.77H18.916L7.084 4.126H5.117L17.083 19.77Z'/></svg></span> </div> <span class="social-item-label"> Twitter/X </span> </a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fbio.news%2Fbio-convention%2Fbio-emerging-start-up-stadium-paradox-immunotherapeutics-biotech%2F&title=BIO%E2%80%99s+Emerging+Start-Up+Stadium+winner%3A+Paradox+Immunotherapeutics&source=Bio.News" aria-label="Linkedin" target="_blank" rel="noopener noreferrer" class="ast-inline-flex ast-social-icon-a"> <div style="--color: #1c86c6; --background-color:transparent;" class="ast-social-element ast-linkedin-social-item"> <span class="ahfb-svg-iconset ast-inline-flex svg-baseline"><svg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 448 512'><path d='M100.28 448H7.4V148.9h92.88zM53.79 108.1C24.09 108.1 0 83.5 0 53.8a53.79 53.79 0 0 1 107.58 0c0 29.7-24.1 54.3-53.79 54.3zM447.9 448h-92.68V302.4c0-34.7-.7-79.2-48.29-79.2-48.29 0-55.69 37.7-55.69 76.7V448h-92.78V148.9h89.08v40.8h1.3c12.4-23.5 42.69-48.3 87.88-48.3 94 0 111.28 61.9 111.28 142.3V448z'></path></svg></span> </div> <span class="social-item-label"> Linkedin </span> </a> </div> </div> </header> <div class="entry-content clear" itemprop="text" > <p><span style="font-weight: 400;">Within the challenging field of protein misfolding research, there is a company with a unique and competitive edge that is turning heads and making therapeutic strides. </span><span style="font-weight: 400;">Following the <a href="https://bio.news/bios-view/bio-international-convention-partnering-is-moving-at-a-record-pace/">2023 Biotechnology Innovation Organization (BIO) International Convention</a>, the Emerging Start-Up winner, </span><a href="https://www.paradoximmuno.com/" target="_blank" rel="noopener"><span style="font-weight: 400;">Paradox Immunotherapeutics</span></a><span style="font-weight: 400;">, was announced.</span></p> <p><span style="font-weight: 400;">Paradox Immunotherapeutics is a biotech company based in Toronto, Canada (and a multi-site JLABS resident company at both JLABS Toronto and JLABS Washington, DC). They are focused on the development of monoclonal antibody (mAb) therapies for the treatment of protein misfolding diseases, including amyloidosis. </span><span style="font-weight: 400;">With more than 30 types of </span><a href="https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2006.05181.x" target="_blank" rel="noopener"><span style="font-weight: 400;">protein misfolding diseases</span></a><span style="font-weight: 400;">, accepted therapy remains in short supply. </span></p> <figure id="attachment_3271" aria-describedby="caption-attachment-3271" style="width: 200px" class="wp-caption alignleft"><img loading="lazy" decoding="async" class="wp-image-3271 lazyload" data-src="https://bio.news/wp-content/uploads/2023/09/nataliegalant-350x311.png" alt="paradox immunotherapeutics" width="200" height="178" data-srcset="https://bio.news/wp-content/uploads/2023/09/nataliegalant-350x311.png 350w, https://bio.news/wp-content/uploads/2023/09/nataliegalant.png 654w" data-sizes="(max-width: 200px) 100vw, 200px" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 200px; --smush-placeholder-aspect-ratio: 200/178;" /><noscript><img loading="lazy" decoding="async" class="wp-image-3271" src="https://bio.news/wp-content/uploads/2023/09/nataliegalant-350x311.png" alt="paradox immunotherapeutics" width="200" height="178" srcset="https://bio.news/wp-content/uploads/2023/09/nataliegalant-350x311.png 350w, https://bio.news/wp-content/uploads/2023/09/nataliegalant.png 654w" sizes="(max-width: 200px) 100vw, 200px" /></noscript><figcaption id="caption-attachment-3271" class="wp-caption-text"><em>Natalie Galant, CEO and Cofounder of Paradox Immunotherapeutics. Image from <a href="https://www.paradoximmuno.com/leadership" target="_blank" rel="noopener">Paradox Immunotherapeutics</a></em>.</figcaption></figure> <p><span style="font-weight: 400;">Bio.News had the opportunity to catch up with one of the Paradox cofounders, and CEO, Dr. Natalie Galant, who presented the company’s current research as part of the 2023 BIO Start-Up Stadium.</span></p> <p><span style="font-weight: 400;">Natalie Galant, Ph.D., and fellow cofounder, Yulong Sun, Ph.D., both received their doctorates in medical biophysics from the University of Toronto. </span></p> <p><span style="font-weight: 400;">Galant’s doctoral research resulted in an antibody that was eventually licensed to Prothena Biosciences Inc., and named PRX004, where it not only cleared safety parameters at all doses but was noted to improve cardiac systolic function in patients with transthyretin amyloidosis (ATTR), which is a result of protein misfolding. PRX004 entered clinical trials in 2018 and</span><a href="https://www.fiercebiotech.com/biotech/novo-nordisk-pays-prothena-100m-for-attr-drug-teeing-up-alnylam-challenge-and" target="_blank" rel="noopener"><span style="font-weight: 400;"> was acquired by Novo Nordisk</span></a><span style="font-weight: 400;"> in a $1.2B acquisition deal in 2021 (recently renamed NNC6019). </span></p> <figure id="attachment_3272" aria-describedby="caption-attachment-3272" style="width: 200px" class="wp-caption alignleft"><img loading="lazy" decoding="async" class="wp-image-3272 lazyload" data-src="https://bio.news/wp-content/uploads/2023/09/yulongsun-350x323.png" alt="" width="200" height="185" data-srcset="https://bio.news/wp-content/uploads/2023/09/yulongsun-350x323.png 350w, https://bio.news/wp-content/uploads/2023/09/yulongsun.png 652w" data-sizes="(max-width: 200px) 100vw, 200px" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 200px; --smush-placeholder-aspect-ratio: 200/185;" /><noscript><img loading="lazy" decoding="async" class="wp-image-3272" src="https://bio.news/wp-content/uploads/2023/09/yulongsun-350x323.png" alt="" width="200" height="185" srcset="https://bio.news/wp-content/uploads/2023/09/yulongsun-350x323.png 350w, https://bio.news/wp-content/uploads/2023/09/yulongsun.png 652w" sizes="(max-width: 200px) 100vw, 200px" /></noscript><figcaption id="caption-attachment-3272" class="wp-caption-text"><em>Yulong Sun, Chief Scientific Officer and Cofounder of Paradox Immunotherapeutics. Image from <a href="https://www.paradoximmuno.com/leadership" target="_blank" rel="noopener">Paradox Immunotherapeutics</a>.</em></figcaption></figure> <p><span style="font-weight: 400;">Galant describes her doctoral work as “the inspiration for Paradox.” She and Sun used the same foundational science to develop a platform that began with a potential treatment for immunoglobulin light chain (AL) amyloidosis. </span></p> <p><span style="font-weight: 400;">They are now aimed to tackle multiple rare protein misfolding diseases, including treatments for chronic renal failure and neurodegeneration.</span></p> <h2>The deviance of protein misfolding</h2> <p><span style="font-weight: 400;">As Galant describes, “proteins are the building blocks of the body and maintain a typical shape in order to perform specific functions.” She further explains, “when proteins change shape, misfold, or go rogue, they can transform into harmful entities and aggregate, resulting in a debilitating disease, such as heart failure caused by AL amyloidosis.” Amyloidosis affects approximately 300 individuals per million worldwide. </span></p> <h2>What is the Paradox approach?</h2> <p><span style="font-weight: 400;">According to Galant, Paradox is poised to change the landscape in a field where “crafting a therapy capable of distinguishing between healthy proteins which perform important roles in the body from more deviant forms that cause disease has historically been a daunting task.” She goes on to explain that “where other biotech companies cast a wide net hoping to ensnare potential drug candidates, Paradox uses a precise and strategic approach to engineer a series of drug candidates with [their] innovative drug discovery platform.”</span></p> <p><span style="font-weight: 400;">Their groundbreaking structural-based drug discovery algorithm “accurately predicts specific regions on a protein that emerge during misfolding.” This multifaceted tool “identifies features on target proteins and has the ability to create opposing antibodies, which then act to single out and remove rogue, misfolded proteins while healthy proteins remain untouched.” </span></p> <h2>The Paradox pipeline</h2> <p><span style="font-weight: 400;">Galant describes the </span><a href="https://www.paradoximmuno.com/pipeline" target="_blank" rel="noopener"><span style="font-weight: 400;">Paradox platform</span></a><span style="font-weight: 400;"> as one designed to offer a “faster and more effective pathway in order to bring candidates from conception to clinic.” “Compared with conventional drug discovery methods that are time-consuming and whose antibodies have undesirable off-target effects, the Paradox platform is efficient, has a better safety profile, and an increased likelihood for clinical success.” </span></p> <p><span style="font-weight: 400;">Paradox is aiming to “maximize their drug discovery platform while positively impacting the outcomes of protein misfolding diseases which are often thought of as incurable.”</span></p> <p><span style="font-weight: 400;">The team at Paradox has a proven track record for success in selectively targeting misfolded proteins with monoclonal antibodies.</span></p> <p><span style="font-weight: 400;">They have developed LX-96, a specialized monoclonal antibody to treat AL amyloidosis, KX-99, for kidney amyloidosis (ALECT2), and NX-86 for neurodegenerative disease.</span></p> <h2>Paradox’s vision for the future</h2> <p><span style="font-weight: 400;">Paradox “envisions leading the global charge against protein misfolding diseases including amyloidosis.” By remaining at the cutting edge of research and development, Paradox aims to continue to “tailor their approach to meet each patient’s specific needs with a goal to unravel protein misfolding.” </span></p> <p><span style="font-weight: 400;">In the midst of their immense success, the deliverables expected from their platform have only touched upon their expected potential within the field of drug development. Paradox is clearly setting a new bar within the biotech industry with a newfound hope to patients around the world.</span></p> <h2>Emerging start-up company recognition</h2> <p><span style="font-weight: 400;">According to Dr. Galant, they “are honored to be recognized amongst a group of highly innovative and ambitious companies.” This achievement is an acknowledgement to the impact of their efforts and strengthens their commitment to make a transformative difference in the lives of patients with protein misfolding diseases and amyloidosis.</span><span style="font-weight: 400;"> </span></p> <h3>The Emerging Start-Up Stage prize</h3> <p><span style="font-weight: 400;">A blog posting by BIO including an interview about the start-up company’s status and mission written by BIO’s communications team and shared via BIO’s social media and listed on BIO’s website</span></p> <p><span style="font-weight: 400;">A complimentary one-year </span><a href="https://www.bio.org/join-today" target="_blank" rel="noopener"><span style="font-weight: 400;">membership</span></a><span style="font-weight: 400;"> in the Biotechnology Innovation Organization, including access to benefit from </span><a href="https://www.bio.org/save/business-solutionsr" target="_blank" rel="noopener"><span style="font-weight: 400;">BIO Business Solutions®</span></a><span style="font-weight: 400;">, the largest cost-savings purchasing program for the life sciences industry. And o</span><span style="font-weight: 400;">ne complimentary registration with BIO One-on-One Partnering™ access to attend the 2024 BIO International Convention, June 3-6, in San Diego, California.</span></p> </div> </div> </article> <div class=" ast-single-author-box ast-author-container--left ast-author-box-position--outside" itemprop="author" itemscope itemtype="https://schema.org/Person" > <div class="ast-author-meta"> <div class="about-author-title-wrapper"> <h3 class="about-author">About The Author</h3> </div> <div class="ast-author-details"> <div class="post-author-avatar"><img alt='' data-src='https://secure.gravatar.com/avatar/69cbdf0f258dbb8a2ecf923961824e28?s=100&d=mm&r=g' data-srcset='https://secure.gravatar.com/avatar/69cbdf0f258dbb8a2ecf923961824e28?s=200&d=mm&r=g 2x' class='avatar avatar-100 photo lazyload' height='100' width='100' decoding='async' src='data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==' style='--smush-placeholder-width: 100px; --smush-placeholder-aspect-ratio: 100/100;' /><noscript><img alt='' src='https://secure.gravatar.com/avatar/69cbdf0f258dbb8a2ecf923961824e28?s=100&d=mm&r=g' srcset='https://secure.gravatar.com/avatar/69cbdf0f258dbb8a2ecf923961824e28?s=200&d=mm&r=g 2x' class='avatar avatar-100 photo' height='100' width='100' decoding='async'/></noscript></div> <div class="post-author-bio"> <a class="url fn n" href="https://bio.news/author/colleen-pietras/" itemprop="url" rel="author" target="_self"> <h4 class="author-title" itemprop="name">Colleen Pietras, M.D.</h4> </a> <div class="post-author-desc">Colleen Pietras, M.D., is a cardiac surgeon, most recently as an assistant professor at Yale University School of Medicine. She was trained in cardiothoracic surgery at Penn State Milton S. Hershey Medical Center, advanced cardiovascular surgery at Mayo Clinic Rochester, and in heart and lung transplantation at the Hospital of the University of Pennsylvania. She has been published in the Annals of Thoracic Surgery and was part of a collaborative book chapter about End-Stage Heart Failure and Mechanical Circulatory Support. She has been a reviewer for the Journal of Heart and Lung Transplantation and the American Society for Artificial Internal Organs.</div> </div> </div> </div></div><div class="ast-single-related-posts-container ast-container--fallback"><div class="ast-related-posts-title-section"> <h2 class="ast-related-posts-title"> Related Posts </h2> </div><div class="ast-related-posts-wrapper"> <article class="ast-related-post post-5397 post type-post status-publish format-standard has-post-thumbnail hentry category-agriculture category-latest-news"> <div class="ast-related-posts-inner-section"> <div class="ast-related-post-content"> <div class="ast-related-post-featured-section post-has-thumb"><div class="post-thumb-img-content post-thumb"><a aria-label="Read more about BIO promotes its partnership with farmers and ranchers at Farm Bureau Convention" href="https://bio.news/agriculture/bio-promotes-its-partnership-with-farmers-and-ranchers-at-farm-bureau-convention/"><img width="982" height="456" 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