State of the Field: CGT Highlights and Approvals of 2023 |

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class="navDropToggle"></div> </li> <li> <a href="/support">Support</a> </li> </ul> <a href="asgct.org" class="px-1 is-external is-hidden-desktop">ASGCT.org</a> </div> </nav> </header> <main class="c-main" id="content"> <section class="c-breadcrumbs"> <div class="container"> <span><a href="/">Home</a> > </span> <a href="/quick-takes" title="Quick Takes" class="CMSBreadCrumbsLink">Quick Takes</a> > <span class="CMSBreadCrumbsCurrentItem">State of the Field: CGT Highlights and Approvals of 2023</span> </div> </section> <section class="section"> <div class="container"> <div class="columns"> <div class="column is-8"> <h1 class="is-like-h2">State of the Field: Highlights and Approvals for CGT in 2023 </h1> </div> </div> <div class="columns"> <div class="column is-8"> <div class="c-leader"> <div class="c-leader-content"><p>The field of gene and cell therapy continues to grow and change with the approval of many new therapies this past year. There is much to highlight about the patient communities affected and what it means for future findings in treatments of rare and genetic conditions. </p></div> </div> <div class="content mb-6"> <p>Check out the quick takes below from Peter Marks, MD, PhD, and Jeffrey Chamberlain, PhD, adddressing the following questions: <em>(Time: 14 min)</em></p> <ul role="list"> <li aria-setsize="-1" data-aria-level="1" data-aria-posinset="2" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="7" role="listitem"> <p paraeid="{98631aff-cdbe-412c-9786-edc3127cb5a0}{144}" paraid="274888517"><span style="font-size:18px;">What were some of the field highlights for you this past year? </span></p> </li> <li aria-setsize="-1" data-aria-level="1" data-aria-posinset="3" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="7" role="listitem"> <p paraeid="{84ad7c93-52f8-4f08-8ccf-99240973c353}{212}" paraid="1563587069"><span style="font-size:18px;">What sort of anticipation does the first CRISPR treatment getting approved create for 2024? </span></p> </li> <li aria-setsize="-1" data-aria-level="1" data-aria-posinset="4" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="7" role="listitem"> <p paraeid="{84ad7c93-52f8-4f08-8ccf-99240973c353}{219}" paraid="406905498"><span style="font-size:18px;">What was unique about 2023 for the CGT field? </span></p> </li> <li aria-setsize="-1" data-aria-level="1" data-aria-posinset="3" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="7" role="listitem"> <p><span style="font-size:18px;">Can you discuss accelerated approval, its role over the last year and why it is such an important part of treatment for rare disease? </span></p> </li> <li aria-setsize="-1" data-aria-level="1" data-aria-posinset="5" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="7" role="listitem"> <p><span style="font-size:18px;">What lessons learned from 2023 will play a role in the way researchers and scientists approach future research for CGT treatments? </span></p> </li> </ul> <div style="padding:56.25% 0 0 0;position:relative;"><iframe allowfullscreen="" frameborder="0" src="https://vimeo.com/showcase/10955543/embed" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></div> <p style="text-align: center;"> </p> <p style="text-align: center;"><a class="c-button-primary" href="https://asgct.qualtrics.com/jfe/form/SV_1NgZIyhyZa2unEq" target="_blank">Take our survey</a></p> <p paraeid="{b28b8ae0-5214-4579-8d7a-9c5adb5b38c8}{221}" paraid="1979204494">2023 was an exciting year for the field, but what do all these approvals mean for access, safety, and long-term outcomes in the communities they affect? To keep you updated on the latest patient education, policy findings, and more, check out ASGCT’s top resources to help expand your knowledge of all things gene and cell. </p> <p paraeid="{b28b8ae0-5214-4579-8d7a-9c5adb5b38c8}{243}" paraid="2074427640">Top three resources on ASGCT.org for staying up to date on the state of the field:  </p> <ul role="list"> <li aria-setsize="-1" data-aria-level="2" data-aria-posinset="1" data-font="Courier New" data-leveltext="o" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1440,"335559991":360,"469769226":"Courier New","469769242":[9675],"469777803":"left","469777804":"o","469777815":"hybridMultilevel"}" data-listid="1" role="listitem"> <p paraeid="{dc23d29d-e55f-4855-81ed-db1064604f03}{9}" paraid="952170408"><span style="font-size:18px;"><a href="https://asgct.informz.net/asgct/pages/The_Advocate_sign_up" rel="noreferrer noopener" target="_blank">Subscribe to the Advocate</a> for monthly highlights in regulatory and policy CGT updates </span></p> </li> <li aria-setsize="-1" data-aria-level="2" data-aria-posinset="2" data-font="Courier New" data-leveltext="o" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1440,"335559991":360,"469769226":"Courier New","469769242":[9675],"469777803":"left","469777804":"o","469777815":"hybridMultilevel"}" data-listid="1" role="listitem"> <p paraeid="{dc23d29d-e55f-4855-81ed-db1064604f03}{29}" paraid="1197488046"><span style="font-size:18px;">Track ongoing research and stay up to date on newly added CGT clinical trials via our updated <a href="https://asgct.careboxhealth.com/en-US" rel="noreferrer noopener" target="_blank">Clinical Trials Finder</a> </span></p> </li> <li aria-setsize="-1" data-aria-level="2" data-aria-posinset="3" data-font="Courier New" data-leveltext="o" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1440,"335559991":360,"469769226":"Courier New","469769242":[9675],"469777803":"left","469777804":"o","469777815":"hybridMultilevel"}" data-listid="1" role="listitem"> <p paraeid="{dc23d29d-e55f-4855-81ed-db1064604f03}{49}" paraid="612122449"><span style="font-size:18px;">Review quarterly <a href="https://asgct.org/publications/landscape-report" rel="noreferrer noopener" target="_blank">Gene and Cell Therapy Lanscape</a> updates and check out all the 2023 highlights below: </span></p> <ul> <li aria-setsize="-1" data-aria-level="2" data-aria-posinset="4" data-font="Courier New" data-leveltext="o" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1440,"335559991":360,"469769226":"Courier New","469769242":[9675],"469777803":"left","469777804":"o","469777815":"hybridMultilevel"}" data-listid="1" role="listitem"> <p paraeid="{dc23d29d-e55f-4855-81ed-db1064604f03}{93}" paraid="1648543636"><span style="font-size:18px;">Hemgenix was approved for hemophilia B in the EU and UK </span></p> </li> <li aria-setsize="-1" data-aria-level="2" data-aria-posinset="3" data-font="Courier New" data-leveltext="o" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1440,"335559991":360,"469769226":"Courier New","469769242":[9675],"469777803":"left","469777804":"o","469777815":"hybridMultilevel"}" data-listid="1" role="listitem"> <p paraeid="{dc23d29d-e55f-4855-81ed-db1064604f03}{209}" paraid="1922718902"><span style="font-size:18px;">FDA approved two cell-based gene therapies, Casgevy and Lyfgenia, to treat sickle cell disease </span></p> </li> <li aria-setsize="-1" data-aria-level="2" data-aria-posinset="4" data-font="Courier New" data-leveltext="o" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1440,"335559991":360,"469769226":"Courier New","469769242":[9675],"469777803":"left","469777804":"o","469777815":"hybridMultilevel"}" data-listid="1" role="listitem"> <p paraeid="{dc23d29d-e55f-4855-81ed-db1064604f03}{228}" paraid="652452828"><span style="font-size:18px;">Casgevy is the first approved therapy in the U.S. that uses CRISPR </span></p> </li> </ul> </li> </ul> <h3 paraeid="{3d2580ea-6701-442a-9144-3f1390616f9b}{1}" paraid="1404149740">Call to Action </h3> <p paraeid="{3d2580ea-6701-442a-9144-3f1390616f9b}{10}" paraid="510280297">As the gene and cell therapy field expands, so will the need for individuals to keep current on accurate, timely scientific findings. If you want to learn more about gene and cell therapy and want to further connect with those working to change the way individuals view treatments for rare diseases, consider <a href="https://asgct.org/membership/become-a-member" target="_blank">becoming an ASGCT member</a> and <a href="https://annualmeeting.asgct.org/register" target="_blank">attending our Annual Meeting</a>.  </p> <p paraeid="{3d2580ea-6701-442a-9144-3f1390616f9b}{60}" paraid="1927499858"><a class="c-button-primary" href="https://asgct.qualtrics.com/jfe/form/SV_1NgZIyhyZa2unEq" target="_blank">Tell us what you think of Community Quick Takes</a></p> <p> </p> <p><strong>Was this information helpful? </strong>If so, please share! All ASGCT Patient Education resources are free to use by sharing on social media, embedding the video, or simply linking to this page! A full media kit <a href="https://asgct.org/global/patient-education/media-kit-state-of-the-cgt-field_feb-2024-cqt.aspx" target="_blank">is available here</a>. <em>Please credit the American Society of Gene and Cell Therapy or tag <a href="https://twitter.com/ASGCTherapy" rel="noreferrer noopener" target="_blank">@ASGCTherapy.</a></em></p> <h2>Thank You to Our Sponsors</h2> <p>The following companies offer their generous support of ASGCT's Community Quick Takes</p> <p><a href="https://www.kitepharma.com/" target="_blank"><img alt="" src="https://asgct.org/getmedia/c0d61d4b-be70-41d9-b1e4-c4a2d3de39ed/kite.aspx?width=200&height=100" style="width: 200px; height: 100px;" /></a><a href="https://www.lexeotx.com/" target="_blank"><img alt="" src="https://asgct.org/getmedia/2dbe79d5-4ab4-4f66-98ac-c9740b8b4c52/lexeo.aspx?width=200&height=100" style="width: 200px; height: 100px;" /></a></p> <p><a href="https://sparktx.com/" target="_blank"><img alt="" src="https://asgct.org/getmedia/ad760f92-ee2f-42fa-831c-209e4f354e96/spark_8.aspx?width=200&height=100" style="width: 200px; height: 100px;" /></a><a href="https://www.ultragenyx.com/" target="_blank"><img alt="" src="https://asgct.org/getmedia/36ee16ef-164b-4402-b998-707be67bbdc8/ultra.aspx?width=200&height=100" style="width: 200px; height: 100px;" /></a></p> </div> </div> <div class="column is-4 pl-4"> <div class="c-nav-local-wrap"> <div class="asideBox"> <h3> Related Pages</h3> <hr class="is-secondary" /> <ul class="c-nav-local-list"> <li class="c-nav-local-item"><a class="c-nav-local-link" href="/quick-takes/focused-ultrasound-in-cell-and-gene-therapies">Focused Ultrasound in CGTs</a> </li> <li class="c-nav-local-item"><a class="c-nav-local-link" href="/quick-takes/access-to-approved-cell-and-gene-therapies">Access to Approved CGTs</a> </li> <li class="c-nav-local-item"><a class="c-nav-local-link" href="/quick-takes/informed-consent">Informed Consent</a> </li> <li class="c-nav-local-item is-active"><a class="c-nav-local-link" href="/quick-takes/state-of-the-field-cgt-highlights-and-approvals-20">State of the Field: CGT Highlights and Approvals of 2023</a> </li> <li class="c-nav-local-item"><a class="c-nav-local-link" href="/quick-takes/genetic-testing-and-clinical-trial-eligibility">Genetic Testing and Clinical Trial Eligibility</a> </li> </ul> </div> </div> </div> </div> </div> <div class="lastUpdatedTag"> <p>Last Updated: 02/28/2024</p> </div> </section> </main> <footer class="c-footer"> <div class="c-footer-primary"> <section class="section"> <div class="container"> <div class="columns"> <div class="column c-footer-section"> <p><img alt="" src="/PatientEducation/media/PatientEducation/logo_white.png" /></p> <p>20800 Swenson Dr., Suite 300<br /> Waukesha, WI 53186</p> </div> <div class="column is-two-fifths c-footer-section"> <ul class="c-utility-list"> <li><a href="#">Gene Therapy 101</a></li> <li><a href="#">Disease Treatments</a></li> <li><a href="#">Clinical Trials</a></li> <li><a href="/patient-journey">Patient Journey</a></li> <li><a href="/about-asgct">About</a></li> <li><a href="/support">Support</a></li> <li><a href="https://asgct.org/about/privacy-policy" target="_blank">Privacy Policy</a></li> </ul> </div> <div class="column c-footer-section"> <h3 class="mb-3">Connect with ASGCT</h3> <p class="mb-0"><span>Phone: 414</span>.278.1341</p> <p><a href="mailto:info@asgct.org">info@asgct.org</a></p> <p> <div class="c-social"> <ul class="c-social-list"> <li class="c-social-item"><a href="https://twitter.com/ASGCTherapy" target="_blank" class="c-social-link twitter"><span class="is-sr-only">Twitter</span></a></li> <li class="c-social-item"><a href="https://www.facebook.com/ASGCTherapy" target="_blank" class="c-social-link facebook"><span class="is-sr-only">Facebook</span></a></li> <li class="c-social-item"><a href="https://www.instagram.com/asgctherapy" target="_blank" class="c-social-link instagram"><span class="is-sr-only">Instagram</span></a></li> <li class="c-social-item"><a href="https://www.linkedin.com/company/asgct" target="_blank" class="c-social-link linkedin"><span class="is-sr-only">LinkedIn</span></a></li> <li class="c-social-item"><a href="https://www.youtube.com/user/ASGCT" target="_blank" class="c-social-link youtube"><span class="is-sr-only">YouTube</span></a></li> </ul> </div> </p> </div> </div> </div> </section> </div> <div class="c-footer-secondary"> <section class="section py-4"> <div class="container"> <div class="columns"> <div class="column"> <p class="is-small">© 2024 All rights reserved. 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State of the Field: CGT Highlights and Approvals of 2023 |