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The Role Of Some Cytokines In The Pathogenesis Of Primary Open Angle Glaucoma

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} </script> <script src="//translate.google.com/translate_a/element.js?cb=googleTranslateElementInit"></script> </ul> </div> </nav> <div class="container-fluid bg-grey"> <div class="container pt-3 pb-4"> <div class="white-container mt-4"> <h2 class="bg-hdr">The Role Of Some Cytokines In The Pathogenesis Of Primary Open Angle Glaucoma</h2> <p style="padding-top: 8px;"><strong>The Role Of Some Cytokines In The Pathogenesis Of Primary Open Angle Glaucoma</strong></p> <p style="padding-top: 8px;"><span><span>Azza Khalil Amer , &nbsp; &nbsp;Hesham Gamal</span></span></p> <p style="padding-top: 8px;"><strong>Purpose:</strong>&nbsp;The aim of this study is to compare human serum levels of some cytokines between 2 stages of primary open-angle glaucoma (POAG) and non-glaucomatous controls.</p> <p style="padding-top: 8px;"><strong>Methods</strong><strong>:</strong> Thirty patients with primary open angle glaucoma (POAG) and 30 normal control subjects were enrolled into this study. The 30 patients with POAG were divided into 2 subgroups according to their mean defect (MD) with MD better than &minus;12&thinsp;dB and worse than &minus;12&thinsp;dB on the visual field. Enzyme-linked immune-sorbent assay was used to assay for the serum levels of T- helper -1 lymphocytes (TH-1) ,IL-12 and IL-23 and &nbsp;tumor necrosis factor (TNF)-alpha, and&nbsp; T-helper-2 (TH-2) lymphocytes , IL-4 and IL-6 in the peripheral blood of different studied groups.</p> <p style="padding-top: 8px;"><strong>Results: </strong>Glaucomatous neuropathy exhibited significant increase in TH-1 cytokines (IL-12) and TH-2 cytokines (IL-4 &amp; IL-6).&nbsp; The difference in TH-1 cytokine (IL-23) was insignificant while the decrease in TH-1 (TNF- alpha) was significant in glaucomatous neuropathy.</p> <div> <p style="padding-top: 8px;"><strong><span>Conclusion: </span></strong><span>Significant alterations of serum TH1 and TH-2 cytokines are associated with glaucoma, suggesting the possibility that abnormal immune environments contribute to the glaucomatous neuropathy of POAG.</span></p> </div> <div class="border-top py-2"><b>Posted by: </b>Azza Khalil Amer, prof, research institute 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