Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic D

<!doctype html> <html lang="de"> <head>  <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta http-equiv="Content-Language" content="de"> <meta name="robots" content="index, follow"> <meta name="googlebot" content="index, follow"> <meta name="google-site-verification" content="IACPFCyYP-SMiV4khyHgqu1j88X5StL99Hd2ePFTlkg" />  <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.4.1/css/bootstrap.min.css">  <link rel="stylesheet" href="https://use.typekit.net/lpc2eiw.css"> <link rel="canonical" href="https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"> <link rel="alternate" href="https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" hreflang="de-DE"/> <link href="https://fonts.googleapis.com/css?family=Spectral:200,200i,300,300i,400,400i,500,500i,600,600i,700,700i,800,800i" rel="stylesheet"> <link href="https://fonts.googleapis.com/css?family=Open+Sans:300,300i,400,400i,600,600i,700,700i,800,800i|Raleway:100,100i,200,200i,300,300i,400,400i,500,500i,600,600i,700,700i,800,800i,900,900i" rel="stylesheet"> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.11.2/css/all.min.css" /> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css">   <link rel="stylesheet" href="/assets/css/jquery.mCustomScrollbar.min.css"> <link href="/assets/css/iconsmind.css" rel="stylesheet"> <link href="/assets/css/metisMenu.min.css" rel="stylesheet"> <link href="/assets/css/mm-vertical-hover.css" rel="stylesheet"> <link rel="stylesheet" href="/assets/css/coolautosuggest.css"> <link rel="stylesheet" href="/assets/css/global.css"> <link rel="stylesheet" href="/assets/css/styles-journals.css">  <link href="/assets/css/main_global.css" rel="stylesheet"> <link rel="stylesheet" href="/assets/css/styles.css"> <link rel="stylesheet" href="/assets/css/author.css">  <script async src="https://www.googletagmanager.com/gtag/js?id=UA-157582964-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-XW4X8M5WLC'); </script>  <div id="target" style="position: absolute; top: 110px;"> <div><p>GET THE APP</p></div> <a href="https://play.google.com/store/apps/details?id=com.journals.iomcworld&hl=en" target="_blank" id="getAppModel"> <div class="a_icon"> <span><i class="fa fa-android"></i></span> </div> </a>  </div>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-GH5GSYYKJG"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-XW4X8M5WLC'); </script> <title>Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic D | 110404</title> <meta name="keywords" content="Bhavana Bhatnagar, Christen Jordan, Cara Randall4, Andrew Gordon, Christinea Marino, Angela Burrie and Ashkan Emadi*, "/> <meta name="description" content="A diagnosis of synchronous cancers within the same individual poses a multitude of diagnostic and treatment-related challenges. Many of these challenges pe..110404"/> <meta name="citation_publisher" content="Internationaler Online-Medizinrat" /> <meta name="citation_journal_title" content="Fallberichte zu Onkologie und Krebs"> <meta name="citation_title" content="Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic Ductal Adenocarcinoma with Germline Heterozygous DDX41 and MUTYH Mutations in a Patient from Appalachia, United States"> <meta name="citation_author" content="Bhavana Bhatnagar" /> <meta name="citation_author" content="Christen Jordan" /> <meta name="citation_author" content="Cara R" /> <meta name="citation_author" content="all4" /> <meta name="citation_author" content="Andrew Gordon" /> <meta name="citation_author" content="Christinea Marino" /> <meta name="citation_author" content="Angela Burrie" /> <meta name="citation_author" content="Ashkan Emadi" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="10"> <meta name="citation_issue" content="3"> <meta name="citation_abstract" content="A diagnosis of synchronous cancers within the same individual poses a multitude of diagnostic and treatment-related challenges. Many of these challenges pertain to the vast heterogeneity in cancers and presentations, patient ineligibility for clinical trials, lack of standardized guidelines to direct management and an incomplete understanding of the molecular mechanisms that contribute to the development of these cancers. We present a case of concurrent diagnoses of Pancreatic Ductal Adenocarcinoma (PDAC) and Acute Myeloid Leukemia (AML) with a comprehensive mutational analysis of the pancreatic tumor, AML blasts, and germline DNA collected from cultured skin fibroblast samples. In addition to some commonly detected mutations (e.g. KRAS Gly12Asp in PDAC and TP53 Met237lle in AML), the genetic testing revealed the presence of DDX41 and MUTYH gene mutations in both germline DNA and tumor tissue specimens. This case underscores the importance of addressing the interplay of genetic, lifestyle and environmental factors in the development of synchronous cancers in an individual, and only by doing so, evidence-based guidelines for early detection and management may be developed."> <meta name="citation_abstract_html_url" content="https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"> </head> <body> <header>  <div class="bg-1"> <div class="container-fluid py-1"> <div class="row justify-content-between align-items-center"> <div class="col-sm-auto"> <a href="https://german.iomcworld.org/" title="IOMC"><img src="/assets/img/IOMC-logo-white.svg" alt="occrs" height="50" alt="IOMC"></a> </div> <div class="col-sm-auto"> <nav class="nav"> <a class="nav-link white"><i class="fa fa-whatsapp"></i> +32(800) 709-48 </a> <a href="mailto:oncology@oncologyinsights.org" class="nav-link white"><i class="fas fa-envelope-square"></i> oncology@oncologyinsights.org</a>  <div class="nav-item dropdown multi_lang j_multi_lang"> <a class="nav-link dropdown-toggle" href="#" id="multi_lang" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Language </a> <div class="dropdown-menu" aria-labelledby=""> <a class="dropdown-item" href="https://www.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="English"> <img src="https://www.longdom.org/admin/flags/usa.png">English </a> <a class="dropdown-item" href="https://spanish.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Spanish"> <img src="https://www.longdom.org/admin/flags/spain.png">Spanish </a> <a class="dropdown-item" href="https://chinese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Chinese"> <img src="https://www.longdom.org/admin/flags/china.png">Chinese </a> <a class="dropdown-item" href="https://russian.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Russian"> <img src="https://www.longdom.org/admin/flags/russia.png">Russian </a> <a class="dropdown-item" href="https://french.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="French"> <img src="https://www.longdom.org/admin/flags/france.png">French </a> <a class="dropdown-item" href="https://japanese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Japanese"> <img src="https://www.longdom.org/admin/flags/japan.png">Japanese </a> <a class="dropdown-item" href="https://portuguese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Portuguese"> <img src="https://www.longdom.org/admin/flags/portugal.png">Portuguese </a> <a class="dropdown-item" href="https://hindi.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Hindi"> <img src="https://www.longdom.org/admin/flags/india.png">Hindi </a> <a class="dropdown-item" href="https://telugu.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Telugu"> <img src="https://www.longdom.org/admin/flags/india.png">Telugu </a> <a class="dropdown-item" href="https://tamil.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Tamil"> <img src="https://www.longdom.org/admin/flags/india.png">Tamil </a> </div> </div>  </nav> </div> </div> </div> </div>  <div class="py-3"> <div class="container-fluid"> <div class="row align-items-center justify-content-between"> <div class="col-12 col-sm-auto"> <h1 class="rockwell fweight-600 mb-0">Fallberichte zu Onkologie und Krebs</h1> <span class="float-right">ISSN - 2471-8556</span> </div> </div> </div> </div>  <nav class="navbar navbar-expand-lg navbar-dark bg-1"> <a class="navbar-brand d-none" href="#">Navbar</a> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#navbarJrnl" aria-controls="navbarJrnl" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-between" id="navbarJrnl"> <ul class="navbar-nav"> <li class="nav-item"> <a class="nav-link active" href="https://german.iomcworld.org/oncology-cancer-case-reports.html" title="">Tagebuch-Startseite</a> </li> <li class="nav-item dropdown"> <a class="nav-link custom-toggle" href="#" id="navbarDropdownMenuLink" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Richtlinien <i class="fa fa-angle-down align-middle" aria-hidden="true"></i> </a>  <div class="dropdown-menu custom-dropdown" aria-labelledby="navbarDropdownMenuLink"> <a class="dropdown-item" href="https://german.iomcworld.org/oncology-cancer-case-reports/aims-and-scope.html">Ziel und Umfang</a> <a class="dropdown-item" href="https://german.iomcworld.org/oncology-cancer-case-reports/guidelines.html">Richtlinien</a> <a class="dropdown-item" href="https://german.iomcworld.org/oncology-cancer-case-reports/peer-review-process.html">Peer-Review-Prozess</a> <a class="dropdown-item" href="https://german.iomcworld.org/oncology-cancer-case-reports/ethical-malpractices.html">Erkl盲rung zu Ver枚ffentlichungsethik und Kunstfehlern</a> </div> </li>  <li class="nav-item"> <a class="nav-link" href="https://german.iomcworld.org/oncology-cancer-case-reports/archive.html" title="">Archiv</a> </li> <li class="nav-item"> <a class="nav-link" href="https://www.scholarscentral.org/submissions/oncology-cancer-case-reports.html" title="">Manuskript einreichen</a> </li> <li class="nav-item"> <a class="nav-link" href="https://german.iomcworld.org/oncology-cancer-case-reports/contact.html" title="">Kontakt</a> </li> </ul> </div> </nav> </header>  <section class="py-5"> <div class="container-fluid"> <div class="row"> <div class="col"> <div class="card"> <h2 class="card-header">Abstrakt</h2> <div class="card-body p-2"> <h3>Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic Ductal Adenocarcinoma with Germline Heterozygous DDX41 and MUTYH Mutations in a Patient from Appalachia, United States</h3> <p> <i class="fas fa-user"></i> Bhavana Bhatnagar, Christen Jordan, Cara Randall4, Andrew Gordon, Christinea Marino, Angela Burrie and Ashkan Emadi* </p> <p><p style="text-align:justify">A diagnosis of synchronous cancers within the same individual poses a multitude of diagnostic and treatment-related challenges. Many of these challenges pertain to the vast heterogeneity in cancers and presentations, patient ineligibility for clinical trials, lack of standardized guidelines to direct management and an incomplete understanding of the molecular mechanisms that contribute to the development of these cancers. We present a case of concurrent diagnoses of Pancreatic Ductal Adenocarcinoma (PDAC) and Acute Myeloid Leukemia (AML) with a comprehensive mutational analysis of the pancreatic tumor, AML blasts, and germline DNA collected from cultured skin fibroblast samples. In addition to some commonly detected mutations (e.g. KRAS Gly12Asp in PDAC and TP53 Met237lle in AML), the genetic testing revealed the presence of DDX41 and MUTYH gene mutations in both germline DNA and tumor tissue specimens. This case underscores the importance of addressing the interplay of genetic, lifestyle and environmental factors in the development of synchronous cancers in an individual, and only by doing so, evidence-based guidelines for early detection and management may be developed.</p> </p> <div class="alert alert-info text-left"><b>Haftungsausschluss:</b> Diese Zusammenfassung wurde mithilfe von Tools der k眉nstlichen Intelligenz 眉bersetzt und wurde noch nicht 眉berpr眉ft oder verifiziert.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Teile diesen Artikel</a> <a title="" target="_blank" href="https://www.facebook.com/sharer.php?u=https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="" target="_blank" href="https://twitter.com/share?url=https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="" target="_blank" href="https://plus.google.com/share?url=https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> <div class="col-12 col-sm-3"> <div class="col">  <div class="card rounded-0 mb-4 sidebar"> <h5 class="mt-n1 mb-0"><span>Zeitschriften-Highlights</span></h5> <div class="card-body p-2 match-height" style="height:350px;overflow:auto;"> <nav class="nav flex-column icon-list icon-list-angle-right"> <a class="nav-link" href="https://german.iomcworld.org/scholarly/liver-cancer-case-reports-journals-articles-ppts-list-4195.html" title="Fallberichte zu Leberkrebs">Fallberichte zu Leberkrebs</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/lung-cancer-case-reports-journals-articles-ppts-list-4199.html" title="Fallberichte zu Lungenkrebs">Fallberichte zu Lungenkrebs</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/hematology-case-reports-journals-articles-ppts-list-4193.html" title="Fallberichte zur Hämatologie">Fallberichte zur Hämatologie</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/radiation-therapy-case-reports-journals-articles-ppts-list-4204.html" title="Fallberichte zur Strahlentherapie">Fallberichte zur Strahlentherapie</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/gynecological-oncology-journals-articles-ppts-list-4368.html" title="Gynäkologische Onkologie">Gynäkologische Onkologie</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/skin-cancer-journals-articles-ppts-list-4203.html" title="Hautkrebs">Hautkrebs</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/integrative-medicine-journals-articles-ppts-list-4202.html" title="Integrative Medizin">Integrative Medizin</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/carcinoma-case-reports-journals-articles-ppts-list-4200.html" title="Karzinom-Fallberichte">Karzinom-Fallberichte</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/cancer-therapeutics-journals-articles-ppts-list-4197.html" title="Krebstherapeutika">Krebstherapeutika</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/neoplasm-journals-articles-ppts-list-4198.html" title="Neubildung">Neubildung</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/oncogenes-journals-articles-ppts-list-4201.html" title="Onkogene">Onkogene</a> <a class="nav-link" href="https://german.iomcworld.org/scholarly/prostate-breast-journals-articles-ppts-list-4194.html" title="Prostata-Brust">Prostata-Brust</a> </nav> </div> </div> </div> <div class="col"> <div class="card rounded-0 mb-4 sidebar"> <h5 class="mt-n1 mb-0"><span>Indiziert in</span></h5> <div class="card-body p-2 match-height"> <ul class="list-unstyled icon-list icon-list-angle-double-right"> <li class="my-3"> Google Gelehrte  </li> <li class="my-3">EBSCO AZ</li> <li class="my-3">Hamdard-Universität</li> <li class="my-3">OCLC – WorldCat</li> <li class="my-3">Publons</li> <li class="my-3">RefSeek</li> <li class="my-3">Scimago</li> <li class="my-3">SCOPUS</li> <li class="my-3">VERÖFFENTLICHT</li> <li class="my-3">Wissenschaftsnetz (Zitierindex für neue Quellen)  </li> </ul> </div> </div> </div> </div> </div> </div> </section> <footer class="bg-1 py-3 text-white"> <div class="container"> <div class="row align-items-center justify-content-between"> <div class="col-12 col-sm-6"> <p class="mb-0">Urheberrechte 漏 © 2024 <a class="text-white" href="https://german.iomcworld.org/" title="">Internationaler Online-Medizinrat</a></p> </div> <div class="col-12 col-sm-6 nav lang_social_icons"> <p> <a title="Click here" target="_blank" href="https://www.facebook.com/profile.php?id=100078365649540"><i class="fab fa-facebook"></i> </a></p> <p><a title="Click here" target="_blank" href="https://twitter.com/iomc8"><i class="fab fa-twitter"></i> </a></p> <p><a target="_blank" href="https://www.instagram.com/iomcworld16/"><i class="fab fa-instagram" aria-hidden="true"></i> </a></p> </div> </div> </div>  <a id="back-to-top" href="#" class="btn btn-light btn-lg back-to-top" role="button"><i class="fas fa-chevron-up"></i></a> </footer>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script src="/assets/js/metisMenu.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? { 'position': 'fixed', 'top': '440px' } : { 'position': 'absolute', 'top': '440px' } ); return fix_element; }()); }); </script>   <script> $("#menu").metisMenu({ triggerElement: '.nav-link', parentTrigger: '.nav-item', subMenu: '.nav.flex-column' }); </script>  <script src="/assets/js/back-to-top.js"></script>  <script type="text/javascript" src="/assets/js/coolautosuggest.js"></script> <script language="javascript" type="text/javascript"> $("#keyword").coolautosuggest({ url: "https://german.iomcworld.org/author-names.php?chars=", minChars: 3, }); </script> <script> $(document).ready(function(){ $(window).scroll(function () { if ($(this).scrollTop() > 50) { $('#back-to-top').fadeIn(); } else { $('#back-to-top').fadeOut(); } }); // scroll body to 0px on click $('#back-to-top').click(function () { $('body,html').animate({ scrollTop: 0 }, 400); return false; }); }); </script> </body> </html>

CINXE.COM

Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic D | 110404