Search results for: Nuris Led贸n

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Led贸n</title> <meta name="description" content="Search results for: Nuris Led贸n"> <meta name="keywords" content="Nuris Led贸n"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Nuris Led贸n"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 4</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Nuris Led贸n</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Results of the Safety Evaluation of Cancer Vaccines Dealing with Novel Targets for Cancer Immunotherapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Axel%20Mancebo">Axel Mancebo</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20M.%20Bada"> Ana M. Bada</a>, <a href="https://publications.waset.org/abstracts/search?q=Angel%20Casac%C3%B3"> Angel Casac贸</a>, <a href="https://publications.waset.org/abstracts/search?q=B%C3%A1rbara%20Gonz%C3%A1lez"> B谩rbara Gonz谩lez</a>, <a href="https://publications.waset.org/abstracts/search?q=Avelina%20Le%C3%B3n"> Avelina Le贸n</a>, <a href="https://publications.waset.org/abstracts/search?q=Mar%C3%ADa%20E.%20Arteaga"> Mar铆a E. Arteaga</a>, <a href="https://publications.waset.org/abstracts/search?q=Consuelo%20Gonz%C3%A1lez"> Consuelo Gonz谩lez</a>, <a href="https://publications.waset.org/abstracts/search?q=Belinda%20S%C3%A1nchez"> Belinda S谩nchez</a>, <a href="https://publications.waset.org/abstracts/search?q=Adriana%20Carr"> Adriana Carr</a>, <a href="https://publications.waset.org/abstracts/search?q=Nuris%20Led%C3%B3n"> Nuris Led贸n</a>, <a href="https://publications.waset.org/abstracts/search?q=Arianna%20Iglesias"> Arianna Iglesias</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Despite the many preventive and therapeutic modalities aimed at curing cancer, it remains as a serious world health problem. Promising recent developments suggest that cancer immunotherapy may be the next great hope for cancer treatment. EGFRs are receptor tyrosine kinases and it is considered an important therapeutic target related with tumor progression, and several types of molecular therapies, including monoclonal antibodies, small molecules, and vaccines, have been developed to target the HER family of receptors. On the other hand, gangliosides are membrane glycosphingolipids that contain two variants of sialic acid, the N-acetylated (NeuAc) and the N-glycolylated (NeuGc) variant. The high expression of this antigen-specific molecule has been associated with malignant tumor progression and immunosuppressive mechanisms, so ganglioside could be considered as the target for cancer immunotherapy. We have been working for several years in the safety evaluation of cancer vaccines targeting these two systems, the EGF receptor and ganglioside. We presented in this work results of repeated dose toxicity studies performed in Sprague Dawley rats and Cynomolgus monkeys, including clinical observations, body weight and rectal temperature measuring, clinical pathology analysis, gross necropsy and histological examination in rodent studies, and immunological evaluation. Immunizations were capable of inducing mainly inflammatory effects at the injection site, with findings largely attributable to the adjuvants used and probably enhanced by the immunological properties of the antigens. In general, these vaccines were shown to be well tolerated, and these studies in relevant species allow treating cancer patients with tumors during long periods with relative weight safety margin. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer%20vaccines" title="cancer vaccines">cancer vaccines</a>, <a href="https://publications.waset.org/abstracts/search?q=safety" title=" safety"> safety</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicology" title=" toxicology"> toxicology</a>, <a href="https://publications.waset.org/abstracts/search?q=rats" title=" rats"> rats</a>, <a href="https://publications.waset.org/abstracts/search?q=non%20human%20primates" title=" non human primates"> non human primates</a> </p> <a href="https://publications.waset.org/abstracts/18736/results-of-the-safety-evaluation-of-cancer-vaccines-dealing-with-novel-targets-for-cancer-immunotherapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18736.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">450</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> The Impact of Human Intervention on Net Primary Productivity for the South-Central Zone of Chile</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yannay%20Casas-Ledon">Yannay Casas-Ledon</a>, <a href="https://publications.waset.org/abstracts/search?q=Cinthya%20A.%20Andrade"> Cinthya A. Andrade</a>, <a href="https://publications.waset.org/abstracts/search?q=Camila%20E.%20Salazar"> Camila E. Salazar</a>, <a href="https://publications.waset.org/abstracts/search?q=Mauricio%20Aguayo"> Mauricio Aguayo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The sustainable management of available natural resources is a crucial question for policy-makers, economists, and the research community. Among several, land constitutes one of the most critical resources, which is being intensively appropriated by human activities producing ecological stresses and reducing ecosystem services. In this context, net primary production (NPP) has been considered as a feasible proxy indicator for estimating the impacts of human interventions on land-uses intensity. Accordingly, the human appropriation of NPP (HANPP) was calculated for the south-central regions of Chile between 2007 and 2014. The HANPP was defined as the difference between the potential NPP of the naturally produced vegetation (NPP0, i.e., the vegetation that would exist without any human interferences) and the NPP remaining in the field after harvest (NPPeco), expressed in gC/m虏 yr. Other NPP flows taken into account in HANPP estimation were the harvested (NPPh) and the losses of NPP through land conversion (NPPluc). The ArcGIS 10.4 software was used for assessing the spatial and temporal HANPP changes. The differentiation of HANPP as % of NPP0 was estimated by each landcover type taken in 2007 and 2014 as the reference years. The spatial results depicted a negative impact on land use efficiency during 2007 and 2014, showing negative HANPP changes for the whole region. The harvest and biomass losses through land conversion components are the leading causes of loss of land-use efficiency. Furthermore, the study depicted higher HANPP in 2014 than in 2007, representing 50% of NPP0 for all landcover classes concerning 2007. This performance was mainly related to the higher volume of harvested biomass for agriculture. In consequence, the cropland depicted the high HANPP followed by plantation. This performance highlights the strong positive correlation between the economic activities developed into the region. This finding constitutes the base for a better understanding of the main driving force influencing biomass productivity and a powerful metric for supporting the sustainable management of land use. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20appropriation" title="human appropriation">human appropriation</a>, <a href="https://publications.waset.org/abstracts/search?q=land-use%20changes" title=" land-use changes"> land-use changes</a>, <a href="https://publications.waset.org/abstracts/search?q=land-use%20impact" title=" land-use impact"> land-use impact</a>, <a href="https://publications.waset.org/abstracts/search?q=net%20primary%20productivity" title=" net primary productivity"> net primary productivity</a> </p> <a href="https://publications.waset.org/abstracts/130455/the-impact-of-human-intervention-on-net-primary-productivity-for-the-south-central-zone-of-chile" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/130455.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Prioritizing Ecosystem Services for South-Central Regions of Chile: An Expert-Based Spatial Multi-Criteria Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yenisleidy%20Martinez%20Martinez">Yenisleidy Martinez Martinez</a>, <a href="https://publications.waset.org/abstracts/search?q=Yannay%20Casas-Ledon"> Yannay Casas-Ledon</a>, <a href="https://publications.waset.org/abstracts/search?q=Jo%20Dewulf"> Jo Dewulf</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The ecosystem services (ES) concept has contributed to draw attention to the benefits ecosystems generate for people and how necessary natural resources are for human well-being. The identification and prioritization of the ES constitute the first steps to undertake conservation and valuation initiatives on behalf of people. Additionally, mapping the supply of ES is a powerful tool to support decision making regarding the sustainable management of landscape and natural resources. In this context, the present study aimed to identify, prioritize and map the primary ES in Biobio and Nuble regions using a methodology that combines expert judgment, multi-attribute evaluation methods, and Geographic Information Systems (GIS). Firstly, scores about the capacity of different land use/cover types to supply ES and the importance attributed to each service were obtained from experts and stakeholders via an online survey. Afterward, the ES assessment matrix was constructed, and the weighted linear combination (WLC) method was applied to mapping the overall capacity of supply of provisioning, regulating and maintenance, and cultural services. Finally, prioritized ES for the study area were selected and mapped. The results suggest that native forests, wetlands, and water bodies have the highest supply capacities of ES, while urban and industrial areas and bare areas have a very low supply of services. On the other hand, fourteen out of twenty-nine services were selected by experts and stakeholders as the most relevant for the regions. The spatial distribution of ES has shown that the Andean Range and part of the Coastal Range have the highest ES supply capacity, mostly regulation and maintenance and cultural ES. This performance is related to the presence of native forests, water bodies, and wetlands in those zones. This study provides specific information about the most relevant ES in Biobio and Nuble according to the opinion of local stakeholders and the spatial identification of areas with a high capacity to provide services. These findings could be helpful as a reference by planners and policymakers to develop landscape management strategies oriented to preserve the supply of services in both regions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ecosystem%20services" title="ecosystem services">ecosystem services</a>, <a href="https://publications.waset.org/abstracts/search?q=expert%20judgment" title=" expert judgment"> expert judgment</a>, <a href="https://publications.waset.org/abstracts/search?q=mapping" title=" mapping"> mapping</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-criteria%20decision%20making" title=" multi-criteria decision making"> multi-criteria decision making</a>, <a href="https://publications.waset.org/abstracts/search?q=prioritization" title=" prioritization"> prioritization</a> </p> <a href="https://publications.waset.org/abstracts/130534/prioritizing-ecosystem-services-for-south-central-regions-of-chile-an-expert-based-spatial-multi-criteria-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/130534.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">126</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Land Suitability Analysis Based on Ecosystems Service Approach for Wind Farm Location in South-Central Chile: Net Primary Production as Proxy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yenisleidy%20Mart%C3%ADnez-Mart%C3%ADnez">Yenisleidy Mart铆nez-Mart铆nez</a>, <a href="https://publications.waset.org/abstracts/search?q=Yannay%20Casas-Led%C3%B3n"> Yannay Casas-Led贸n</a>, <a href="https://publications.waset.org/abstracts/search?q=Jo%20Dewulf"> Jo Dewulf</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wind power constitutes a cleaner energy source with smaller unfavorable impacts on the environment than fossil fuels. Its development could be an alternative to fight climate change while meeting energy demands. However, wind energy development requires first determining the existing potential and areas with aptitude. Also, potential socio-economic and environmental impacts should be analyzed to prevent social rejection of this technology. In this context, this work performs a suitability assessment on a GIS environment to locate suitable areas for wind energy expansion in South-Central Chile. In addition, suitable areas were characterized in terms of potential goods and services to be produced as a proxy for analyzing potential impacts and trade-offs. First, layers of annual wind speed were generated as they represent the resource potential, and layer representing previously defined territorial constraints were created. Zones depicting territorial constraints were removed from resource measurement layers to identify suitable sites. Then, the appropriation of the primary production in suitable sites was determined to measure potential ecosystem services derived from human interventions in those areas. Results show that approximately 52% of the total surface of the study area has a good aptitude to install wind farms. In this area, provisioning services like food crops production, timber, and other forest resources like firewood play a key role in the regional economy and thus are the main cause of human interventions. This is reflected by human appropriation of the primary production values of 0.71 KgC/m虏.yr, 0.36 KgC/m虏.yr, and 0.14 KgC/m虏.yr, respectively. In this sense, wind energy development could be compatible with croplands, which is the predominant land use in suitable areas, and provide farmers with cheaper energy and extra income. Also, studies have reported changes in local temperature associated with wind turbines, which could be beneficial to crop growth. The results obtained in this study prove to be useful for identifying available areas for wind development, which could be very useful in decision-making processes related to energy planning. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=net%20primary%20productivity" title="net primary productivity">net primary productivity</a>, <a href="https://publications.waset.org/abstracts/search?q=provisioning%20services" title=" provisioning services"> provisioning services</a>, <a href="https://publications.waset.org/abstracts/search?q=suitability%20assessment" title=" suitability assessment"> suitability assessment</a>, <a href="https://publications.waset.org/abstracts/search?q=wind%20energy" title=" wind energy"> wind energy</a> </p> <a href="https://publications.waset.org/abstracts/142560/land-suitability-analysis-based-on-ecosystems-service-approach-for-wind-farm-location-in-south-central-chile-net-primary-production-as-proxy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142560.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div 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Search results for: Nuris Led贸n