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src="https://www.j-alz.com/sites/default/files/banner/slider_240448.jpg" alt="pRac/Cdc42" title="#htmlcaption-12" /></a><a href="https://www.j-alz.com/content/therapeutic-trials-alzheimer%E2%80%99s-disease-where-are-we-now"><img class="slide" id="slide-13" data-thumb="https://www.j-alz.com/sites/default/files/banner/AIAD%2012%20slider%20voor%20de%20JAD%20website.png" data-transition="" typeof="foaf:Image" src="https://www.j-alz.com/sites/default/files/banner/AIAD%2012%20slider%20voor%20de%20JAD%20website.png" alt="AIAD Volume 12" title="&lt;p&gt;Edited by P. I. Moreira, J. Avila, D. Galimberti, M. A. Pappolla, G. Plascencia-Villa, A. A. Sorensen, X. Zhu, G. Perry. This book (AIAD, Vol. 12) provides an overview of efforts in the attempt to address AD, and will be of interest to all involved in the research and treatment of AD.&lt;/p&gt;" /></a> </div> </div> <div id="htmlcaption-0" class="nivo-html-caption"><p><em>Upcoming Supplement Issue:</em> <strong>Sensory Loss in Alzheimer's Disease and Related Dementias</strong> (Guest Editors: Willa Brenowitz, Jennifer Deal, Joshua Ehrlich, Kristine Yaffe)</p> <p>Click the visual for details in the Call for Papers (PDF) (opens in a new tab). Submission deadline: April 1, 2025</p> </div><div id="htmlcaption-1" class="nivo-html-caption"><div class="title"><em>Journal of Alzheimer's Disease</em></div> <p>is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.</p> <p><a href="http://j-alz.com/about">LEARN MORE</a></p> </div><div id="htmlcaption-2" class="nivo-html-caption"><p>Both primary neurons and astrocytes exhibit calcium overload with the addition of toxic soluble Aβ oligomers. However, this calcium overload is prevented when pre-treated with NB-02, a novel botanical drug. From Miller et al., JAD99(2).</p> </div><div id="htmlcaption-3" class="nivo-html-caption"><p>JAD proudly releases a celebratory supplemental issue in honor of its 100th volume.</p> </div><div id="htmlcaption-4" class="nivo-html-caption"><p>AD patients had higher free water versus controls in limbic areas, precuneus, frontal/temporal lobes, putamen, and cerebellum. From Nakaya et al., JAD99(4).</p> </div><div id="htmlcaption-5" class="nivo-html-caption"><p>Edited by C.A. Raji, Y. Leng, J.W. Ashford, and D.S. Khalsa, this book (AIAD, Vol. <strong>10</strong>) introduces physicians, scientists, and other stakeholders to this subfield of AD research.</p> </div><div id="htmlcaption-6" class="nivo-html-caption"><p>Edited by C.A. Raji, Y. Leng, J.W. Ashford, and D.S. Khalsa, this book (AIAD, Vol. <strong>11</strong>) is a comprehensive overview of strategies for tackling Alzheimer’s disease and will be of interest to all those working in the field.</p> </div><div id="htmlcaption-7" class="nivo-html-caption"><p>Exploring the impact of different single or combinations of vascular risk factors on the shared vulnerable brain regions and white matter structural network for vascular risk and Alzheimer's disease in middle-aged and elderly individuals. From Wang et al., JAD99(4).</p> </div><div id="htmlcaption-8" class="nivo-html-caption"><p>New Co-Editor-in-Chief Appointed:<br /> Paula I. Moreira, PhD, is an Associate Professor of Physiology and leads the Mitochondria in Brain Disorders research group at the Center for Neuroscience and Cell Biology at the University of Coimbra.</p> </div><div id="htmlcaption-9" class="nivo-html-caption"><p>We examined the positional relationship between NOTCH3ECD and mitochondria using immunofluorescence. We found that NOTCH3ECD displays a strong co-localization with mitochondria in both the control group and the mutant group. From Wang et al., JAD 100(4).</p> </div><div id="htmlcaption-10" class="nivo-html-caption"><p>JAD Reports is our fully <strong>open access</strong> international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. <a href="http://tiny.cc/JADRcontent" target="_blank"><strong>View new content</strong></a></p> </div><div id="htmlcaption-11" class="nivo-html-caption"><p>Human Alzheimer's brains showed increased ferritin and transferrin receptor (TfR) expression and TfR+ neurons and ferritin+ microglia were frequently detected in spatial proximity to p-Tau+ structures. From Mayr et al., JAD102(4).</p> </div><div id="htmlcaption-12" class="nivo-html-caption"><p>Plane based cytoplasmic to nuclear localization of pRac/Cdc42 (S71). Top) In the rostral part of the mouse cortex pRac/Cdc42 (S71) is absent from the nucleus. Bottom) Deeper into the cortex, pRac/Cdc42 (S71) is present in the nucleus. From Nik Akhtar et al. JAD 102(3).</p> </div> </div> </div> </div> </div> </div> </div> </div></header> <section id="section-content" class="section section-content"> <div id="zone-content-wrapper" class="zone-wrapper zone-content-wrapper clearfix"> <div id="zone-content" class="zone zone-content clearfix container-12"> <aside class="grid-3 region region-sidebar-first" id="region-sidebar-first"> <div class="region-inner region-sidebar-first-inner"> <section class="block block-views block-latest-news-block block-views-latest-news-block odd" id="block-views-latest-news-block"> <div class="block-inner clearfix"> <h2 class="block-title">News</h2> <div class="content clearfix"> <div class="view view-latest-news view-id-latest_news view-display-id-block view-dom-id-9b941bb9b11f96b25026440ac992568c"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first"> <div class="views-field views-field-field-image"> <div class="field-content"><img typeof="foaf:Image" src="https://www.j-alz.com/sites/default/files/styles/jad_thumbnail/public/field/image/JAD220x220_31_0_0.jpg?itok=aoOpurqM" width="75" height="75" alt="Journal of Alzheimer's Disease" /></div> </div> <div class="views-field views-field-title"> <span class="field-content"><a href="/content/therapeutic-trials-alzheimer%E2%80%99s-disease-where-are-we-now">Therapeutic Trials in Alzheimer’s Disease: Where Are We Now?</a></span> </div> </div> <div class="views-row views-row-2 views-row-even"> <div class="views-field views-field-field-image"> <div class="field-content"><img typeof="foaf:Image" src="https://www.j-alz.com/sites/default/files/styles/jad_thumbnail/public/field/image/LubnaaAbdullah.jpg?itok=4g6ux47p" width="75" height="75" alt="Lubnaa Abdullah" /></div> </div> <div class="views-field views-field-title"> <span class="field-content"><a href="/content/journal-alzheimers-disease-publishes-key-unthsc-study-biomarkers-diverse-populations">Journal of Alzheimer’s Disease publishes key UNTHSC study on biomarkers in diverse populations </a></span> </div> </div> <div class="views-row views-row-3 views-row-odd views-row-last"> <div class="views-field views-field-field-image"> <div class="field-content"><img typeof="foaf:Image" src="https://www.j-alz.com/sites/default/files/styles/jad_thumbnail/public/field/image/Bregman.png?itok=dOC2S2uR" width="75" height="75" alt="" /></div> </div> <div class="views-field views-field-title"> <span class="field-content"><a href="/content/new-study-highlights-physician-perspectives-emerging-anti-amyloid-treatments">New Study Highlights Physician Perspectives on Emerging Anti-Amyloid Treatments for Alzheimer’s Disease in Israel</a></span> </div> </div> </div> <div class="more-link"> <a href="/latest-news"> VIEW MORE </a> </div> </div> </div> </div> </section><section class="block block-views block-editor-s-pick-block block-views-editor-s-pick-block even" id="block-views-editor-s-pick-block"> <div class="block-inner clearfix"> <h2 class="block-title">Editor's Choice</h2> <div class="content clearfix"> <div class="view view-editor-s-pick view-id-editor_s_pick view-display-id-block view-dom-id-e3a7d861e330a354f78fd389a71770b9"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first"> <article about="/content/increased-risk-dementia-associated-herpes-simplex-virus-infections-evidence-retrospective" typeof="sioc:Item foaf:Document" class="node node-biblio node-teaser node-published node-not-promoted node-not-sticky author-admin odd clearfix" id="node-biblio-133261"> <div class="biblio-editors-pick">Editors' Pick</div> <span property="dc:title" content="Increased risk of dementia associated with herpes simplex virus infections: Evidence from a retrospective cohort study using U.S. electronic health records." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content clearfix"> <div class="biblio-title"><a href="/content/increased-risk-dementia-associated-herpes-simplex-virus-infections-evidence-retrospective">Increased risk of dementia associated with herpes simplex virus infections: Evidence from a retrospective cohort study using U.S. electronic health records.</a></div> <div class="biblio-authors">Araya K, et al., <em class="biblio-journal">J Alzheimers Dis</em>.<span class="biblio-date">, 2025 Feb 16</span>.</div> <div class="clearfix"> </article> </div> <div class="views-row views-row-2 views-row-even"> <article about="/content/white-matter-lesions-rather-amyloid-%CE%B2-burden-are-associated-cognitive-decline-alzheimers" typeof="sioc:Item foaf:Document" class="node node-biblio node-teaser node-published node-not-promoted node-not-sticky author-admin even clearfix" id="node-biblio-133263"> <div class="biblio-editors-pick">Editors' Pick</div> <span property="dc:title" content="White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content clearfix"> <div class="biblio-title"><a href="/content/white-matter-lesions-rather-amyloid-%CE%B2-burden-are-associated-cognitive-decline-alzheimers">White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease.</a></div> <div class="biblio-authors">Kasahara H, et al., <em class="biblio-journal">J Alzheimers Dis</em>.<span class="biblio-date">, 2025 Feb 16</span>.</div> <div class="clearfix"> </article> </div> <div class="views-row views-row-3 views-row-odd"> <article about="/content/sex-specific-effects-apolipoprotein-e-%CE%B54-genotype-longitudinal-hippocampal-atrophy-amnestic" typeof="sioc:Item foaf:Document" class="node node-biblio node-teaser node-published node-not-promoted node-not-sticky author-admin odd clearfix" id="node-biblio-133260"> <div class="biblio-editors-pick">Editors' Pick</div> <span property="dc:title" content="Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content clearfix"> <div class="biblio-title"><a href="/content/sex-specific-effects-apolipoprotein-e-%CE%B54-genotype-longitudinal-hippocampal-atrophy-amnestic">Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period.</a></div> <div class="biblio-authors">Park CHyun, et al., <em class="biblio-journal">J Alzheimers Dis</em>.<span class="biblio-date">, 2025 Feb 09</span>.</div> <div class="clearfix"> </article> </div> <div class="views-row views-row-4 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class="biblio-authors">Ndukwe K, et al., <em class="biblio-journal">J Alzheimers Dis</em>.<span class="biblio-date">, 2025 Feb 09</span>.</div> <div class="clearfix"> </article> </div> </div> <div class="more-link"> <a href="/editors-pick"> VIEW MORE </a> </div> </div> </div> </div> </section><section class="block block-block block-11 block-block-11 odd" id="block-block-11"> <div class="block-inner clearfix"> <h2 class="block-title">Upcoming Meetings</h2> <div class="content clearfix"> <div class="field-content"> <div class="views-field-title"><a href="https://www.euroccn.com/" target="_blank"><img src="/sites/default/files/ECCN1.jpg" alt="" width="75" height="75" />European Conference on Clinical Neuroscience<br />24-26 March 2025<br />Madrid, Spain </a></div> <div class="views-field-title"> </div> <div class="views-field-title"> </div> </div> <div class="field-content"> <div class="views-field-title"><a href="https://www.cogneurosociety.org/annual-meeting/" target="_blank"><img 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alt="" width="75" height="75" />CNS 2025 Annual Meeting<br />29 March – 1 April 2025<br />Boston, MA, USA</a></div> <div class="views-field-title"> </div> <div class="views-field-title"> </div> </div> <div class="field-content"> <div class="views-field-title"><a href="https://adpd.kenes.com/" target="_blank"><img src="/sites/default/files/ADPD2025.png" alt="" width="75" height="75" />AD/PD 2025: Advances in Science & Therapy<br />1-5 April 2025<br />Vienna, Austria</a></div> <div class="views-field-title"> </div> </div> <div class="more-link" style="text-align: left;"><a href="/conferences">VIEW MORE </a></div> <p><!--code for upcoming conferences</p><div class="field-content"> <div class="views-field-title"><a href="https://aaic.alz.org/" target="_blank"><img src="/sites/default/files/AAIC25.png" alt="" width="75" height="75" />Alzheimer's Association International Conference<br />27-31 July 2025<br />Toronto, Canada </a></div> <div class="views-field-title"> </div> </div> <div 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