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</span> <span class="icon-bar bar3 twist"> </span></button><button aria-expanded="false" class="navbar-toggle collapsed" data-target="#porphyriaNav" data-toggle="collapse" type="button"><span class="sr-only">Toggle navigation</span></button><a aria-label="Thinkporphyria.eu website logo" class="navbar-brand" href="/it" id="pdlogo" role="img" title="Thinkporphyria.eu"><span class="sr-only"><strong>Thinkporphyria.eu</strong></span></a></div>  <div class="collapse navbar-collapse" id="porphyriaNav"> <ul class="nav navbar-nav navbar-right"> <li><a class="new_gtm_click" data_event_action="Main" data_event_category="Navigation" data_event_label="About AHP" href="/it/informazioni-ahp">INFORMAZIONI SULL’AHP</a></li> <li><a class="new_gtm_click" data_event_action="Main" data_event_category="Navigation" data_event_label="Signs & Symptoms" href="/it/segni-e-sintomi">SEGNI E SINTOMI</a></li> <li><a class="new_gtm_click" data_event_action="Main" data_event_category="Navigation" data_event_label="Testing for AHP" href="/it/test-per-ahp">TEST PER L’AHP</a></li> <li><a class="new_gtm_click" data_event_action="Main" data_event_category="Navigation" data_event_label="Resources" href="/it/risorse">RISORSE</a></li> <li class="last"><a class="new_gtm_click new_gtm_click_2" data_event_action="Click" data_event_action_2="Main" data_event_category="Callouts" data_event_category_2="Navigation" data_event_label="VISIT PATIENT SITE" data_event_label_2="VISIT PATIENT SITE" href="https://www.livingwithporphyria.eu/it"><span>SITO PER I PAZIENTI <img src="/sites/default/files/images_site/ico_link_esterno.png" /></span></a></li> </ul> </div> <a href="/"> </a></div> <a href="/"> </a></nav> </div> </div> </div> </header> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div> <div data-drupal-messages-fallback class="hidden"></div><div id="block-porphyria-content"> <article data-history-node-id="2" role="article" about="/it/node/2" typeof="schema:WebPage"> <span property="schema:name" content="IT - Home page" class="hidden"></span> <div> <div property="schema:text"><div class="barberpole home"> <div class="stripes"> <div class="bg white visible-lg-*" style="height:735px;"> </div>  <div class="bg blue visible-lg-*" style="height:1140px;"> </div>  <div class="bg white visible-lg-*" style="height:735px;"> </div>  <div class="bg pink visible-lg-*" style="height:1140px;"> </div>  <div class="bg white visible-lg-*" style="height:1035px;"> </div>  <div class="bg blue visible-lg-*" style="height:1140px;"> </div>  <div class="bg white visible-lg-*" style="height:735px;"> </div> </div> </div> <main class="page" id="hcp_home"> <div class="striped"> <section class="intro mb-0"><img alt="" class="intro-img dk" src="/themes/custom/porphyria/assets/images/it/homehero.png" /> <img alt="" class="intro-img mb" src="/themes/custom/porphyria/assets/images/it/homeheromobile.png" /> <div class="clipboard"> <div class="container"> <div class="row"> <div class="col-xs-12 col-sm-12 col-md-5 col-lg-4 col-lg-push-1"> <h1 class="intro-title"><span>AHP: LA DIAGNOSI GIUSTA È L’UNICA VIA D’USCITA</span></h1> </div> <div class="col-xs-12 col-sm-12 col-md-7 col-lg-6 col-lg-push-1"> <div class="intro-card"> <p>Per <strong>porfiria epatica acuta (AHP)</strong> si intende una famiglia di malattie genetiche rare con una prevalenza in Europa stimata a 5,4 per milione. Tuttavia, la prevalenza di alcuni tipi di AHP può essere più alta di quanto si supponga. Può essere caratterizzata da attacchi potenzialmente letali e, per alcuni pazienti, da sintomi cronici debilitanti che hanno un impatto negativo sulla vita quotidiana e sulla qualità della vita. Alcuni pazienti possono anche essere a rischio di neuropatia progressiva irreversibile.<sup>1-8</sup></p> <p>I sintomi possono spesso assomigliare a quelli di altre malattie più comuni, come la sindrome dell'intestino irritabile, la fibromialgia, l'endometriosi o anche alcuni disturbi psichiatrici. <strong>Di conseguenza, i pazienti affetti da AHP ricevono spesso una diagnosi non corretta o restano senza diagnosi anche per 15 anni.</strong><sup>5,8-10</sup></p> </div> </div> </div> </div> </div> <div class="container"> <div class="row"> <div class="col-xs-12 col-sm-12 col-md-12 col-lg-10 col-lg-push-1"> <div class="intro-boxes" style="margin-bottom:70px;"> <div class="intro-box new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Understand AHP"><a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Understand AHP" href="/it/informazioni-ahp"><i class="b1 new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Understand AHP"> </i> </a> <p><a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Understand AHP" href="/it/informazioni-ahp">Comprendere l’AHP</a></p> <a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Understand AHP" href="/it/informazioni-ahp"> <span class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Understand AHP"> </span> </a></div> <div class="intro-box new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Recognize Signs Symptoms"><a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Recognize Signs Symptoms" href="/it/segni-e-sintomi"><i class="b2 new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Recognize Signs Symptoms"> </i> </a> <p><a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Recognize Signs Symptoms" href="/it/segni-e-sintomi">Riconoscere i segni e sintomi</a></p> <a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Recognize Signs Symptoms" href="/it/segni-e-sintomi"> <span class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Recognize Signs Symptoms"> </span> </a></div> <div class="intro-box new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Diagnose AHP"><a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Diagnose AHP" href="/it/test-per-ahp"><i class="b3 new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Diagnose AHP"> </i> </a> <p><a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Diagnose AHP" href="/it/test-per-ahp">Diagnosi e test per l’AHP</a></p> <a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Diagnose AHP" href="/it/test-per-ahp"> <span class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Diagnose AHP"> </span> </a></div> <div class="intro-box new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Resources"><a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Resources" href="/it/risorse"><i class="b4 new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Resources"> </i> </a> <p><a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Resources" href="/it/risorse">Risorse</a></p> <a class="new_gtm_click" data_event_action="Click" data_event_category="Callouts" data_event_label="Resources" href="/it/risorse"> <span 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<label class="white-field l-term mb-60 font-italic" data-drupal-selector="edit-by-submitting-this-form-i-declare-that-" for="edit-by-submitting-this-form-i-declare-that-">Inviando questo modulo, dichiaro che:</label><div class="white-field l-term js-form-item form-item js-form-type-checkbox form-item-like-to-receive js-form-item-like-to-receive"> <input class="cheaking mt-20 form-checkbox required" data-webform-required-error="- Accetta i termini" data-drupal-selector="edit-like-to-receive" aria-describedby="edit-like-to-receive--description" type="checkbox" id="edit-like-to-receive" name="like_to_receive" value="1" required="required" aria-required="true" /> <label for="edit-like-to-receive" class="option js-form-required form-required">Sono un operatore sanitario e ho letto e compreso i termini e le condizioni relativi al trattamento dei miei dati personali come indicato in dettaglio nelle politiche sulla <strong>privacy di Alnylam</strong> e nella relativa <strong>dichiarazione 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data-drupal-selector="edit-email-duplicate" type="hidden" name="email_duplicate" value="0" /> <input data-drupal-selector="lang" type="hidden" name="language" value="" /> <div data-drupal-selector="edit-actions" class="form-actions webform-actions js-form-wrapper form-wrapper" id="edit-actions"><input class="webform-button--submit button button--primary js-form-submit form-submit" data-drupal-selector="edit-actions-submit" type="submit" id="edit-actions-submit" name="op" value="ISCRIVITI ORA" /> </div> </div> <input autocomplete="off" data-drupal-selector="form-7d3gayvwj43jn0soxzqf7f5mc88n56uwuhigvj-guu8" type="hidden" name="form_build_id" value="form-7D3gAyvwj43jn0SOXZqf7F5mC88N56uwuHIGvJ_guU8" /> <input data-drupal-selector="edit-webform-submission-signupform-node-2-add-form" type="hidden" name="form_id" value="webform_submission_signupform_node_2_add_form" /> </form> </div> <div class="views-element-container" id="block-views-block-view-footer-custom-block-block-view-footer"> <div><div class="js-view-dom-id-7bd7a7dd458ce0ebc9184e8c1394f11ccc1c84fccb9520a4f386cecca5ea25b5"> <div class="views-row"> <div> <div class="page"> <div class="legal"> <div class="container"> <div class="content-wrapper"> <div class="row"> <div class="col-xs-12 col-sm-12 col-md-12 col-lg-10 col-lg-push-1"> <p><small><strong>Bibliografia: 1. </strong>Elder G, Harper P, Badminton M, et al. The incidence of inherited porphyrias in Europe. <em>J Inherit Metab Dis</em>. 2013;36:849–857. <strong>2. </strong>Ramanujam VM, Anderson KE. <em>Curr Protoc Hum Genet</em>. 2016; Jul 1;86:17.20.1-26. <strong>3. </strong>Desnick R, Bonkovsky HL. Expert Seminar on Porphyria. 2016; Cambridge, MA. <strong>4.</strong> Bissell DM, Wang B. <em>J Clin Transl Hepatol</em>. 2015;3(1):17-26. <strong>5.</strong> Anderson KE, Bloomer JR, Bonkovsky HL, et al. <em>Ann lntem Med</em>. 2005;142(6):439-450. <strong>6.</strong> Gouya L, et al. EXPLORE: A Prospective, Multinational, Natural History Study of Patients with Acute Hepatic Porphyria with Recurrent Attacks. <em>Hepatology</em>. 2020; May;71(5):1546-1558. <strong>7.</strong> Simon A, Pompilus F, Querbes W, et al. <em>Patient</em>. 2018;11(5):527-537. <strong>8.</strong> Ko JJ, Murray S, Merkel M, et al. Poster presented at: American College of Gastroenterology Annual Meeting; October 5-10, 2018; Philadelphia, PA. <strong>9. </strong>Bonkovsky HL, Maddukuri VC, Yazici C, et al. <em>Am J Med</em>. 2014;127(12):1233-1241. <strong>10.</strong> Kondo M, Yano Y, Shirataka M, Urata G, Sassa S. <em>Int J Hematol</em>. 2004;79(5):448-456.</small></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div>  </div> <footer> <div> <div id="block-emailsent"> <div> <div aria-labelledby="myModalLabel" class="modal fade" id="email_sent" role="dialog" tabindex="-1"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"></button></div> <div class="modal-body all-modal"> <p class="common-head">E-mail inviata!</p> <p class="common-body">È stato inviato un link al tuo indirizzo e-mail</p> <div class="button-container"><a class="box-link success" href="/">OK</a></div> </div> </div> </div> </div> </div> </div> <div id="block-hcpfooter"> <div><div class="container"> <div class="row"> <div class="col-md-2"><a class="new_gtm_click" data_event_action="Alnylam Pharmaceuticals logo" data_event_category="Exits" data_event_label="http://www.alnylam.com/" href="http://www.alnylam.com/" target="_blank"><img alt="Alnylam® Pharmaceuticals logo" class="new_gtm_click new_gtm_click_2" data_event_action="Alnylam Pharmaceuticals logo" data_event_action_2="Footer" data_event_category="Exits" data_event_category_2="Navigation" data_event_label="http://www.alnylam.com/" data_event_label_2="Alnylam Pharmaceuticals logo" id="img-logo-footer" src="/themes/custom/porphyria/assets/images/AlnylamLogo.png" title="Alnylam® Pharmaceuticals" /> </a></div> <div class="col-md-7 col-md-offset-1"> <p><a class="new_gtm_click" data_event_action="Footer" data_event_category="Navigation" data_event_label="About AHP" href="/it/informazioni-ahp" id="footer-about">Informazioni sull'AHP</a> | <a class="new_gtm_click" data_event_action="Footer" data_event_category="Navigation" data_event_label="Signs & Symptoms" href="/it/segni-e-sintomi" id="footer-signs">Segni e Sintomi</a> |<br class="visible-xs" /> <a class="new_gtm_click" data_event_action="Footer" data_event_category="Navigation" data_event_label="Testing for AHP" href="/it/test-per-ahp" id="footer-testing">Test per l'AHP</a> | <a class="new_gtm_click" data_event_action="Footer" data_event_category="Navigation" data_event_label="Resources" href="/it/risorse" id="footer-resources">Risorse</a></p> <p><a class="new_gtm_click new_gtm_click_2" data_event_action="Footer" data_event_action_2="Contact Us" data_event_category="Navigation" data_event_category_2="Exits" data_event_label="Contact Us" data_event_label_2="https://alnylampolicies.com/" href="https://alnylampolicies.com/" id="footer-contact" target="_blank">Contattaci</a> | <a class="new_gtm_click new_gtm_click_2" data_event_action="Footer" data_event_action_2="Privacy Policy" data_event_category="Navigation" data_event_category_2="Exits" data_event_label="Privacy Policy" data_event_label_2="https://alnylampolicies.com/" href="https://alnylampolicies.com/" id="privacy" target="_blank">Politica sulla Privacy</a> | <a class="new_gtm_click new_gtm_click_2" data_event_action="Footer" data_event_action_2="Legal Notice" data_event_category="Navigation" data_event_category_2="Exits" data_event_label="Legal Notice" data_event_label_2="https://alnylampolicies.com/" href="https://alnylampolicies.com/" id="terms-of-use-exit" target="_blank">Nota legale</a> | <a class="new_gtm_click new_gtm_click_2" data_event_action="Footer" data_event_action_2="Cookie Policy" data_event_category="Navigation" data_event_category_2="Exits" data_event_label="Cookie Policy" data_event_label_2="https://alnylampolicies.com/" href="https://alnylampolicies.com/" id="cookie-policy-footer" target="_blank">Politica sui Cookie</a></p> <p>© 2021 Alnylam Pharmaceuticals, Inc. 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