Search|Resources to understand how Alnylam鈥檚 RNAi-based medicines work

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# "> <head> <meta charset="utf-8" /> <meta name="description" content="Use the Search feature to discover educational content based on key terms and explore results to your inquiries about RNAi-based medicines, therapeutic pipeline, and more." /> <link rel="canonical" href="https://www.rnaiscience.com/search" /> <meta property="og:url" content="https://www.rnaiscience.com/search" /> <meta property="og:title" content="Search|Resources to understand how Alnylam鈥檚 RNAi-based medicines work" /> <meta property="og:description" content="Explore results to your inquiries about RNAi-based medicines, therapeutic pipeline, and more." /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/sites/default/files/al-favicon.png" type="image/png" /> <title>Search|Resources to understand how Alnylam鈥檚 RNAi-based medicines work</title> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_BFMKVjyys4a9tmYqxVo94T6bZvTR_a5jv8zd48fozq8.css?delta=0&language=en&theme=alnylam&include=eJxVTlsOwjAMu1BpjoRcGrpC-lCywsbpYQiY-LHkl2xbbeZCAcYOUldBoSQtQA6Sg0LXn_yXKWyGxOZOTZlq0wLJD3a8zJLrlaKODvEf6joUSdEn-zq74kftI0i2iaO7Zb4bvdGXFofwq5tYWakMmXNH3U_UFtmdBYk28NvSERcsT6OiUsE" /> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_laqRp-5lYR55W3Uq-i1hvOK1Ou7k4icRKsmJ6fh1Fmw.css?delta=1&language=en&theme=alnylam&include=eJxVTlsOwjAMu1BpjoRcGrpC-lCywsbpYQiY-LHkl2xbbeZCAcYOUldBoSQtQA6Sg0LXn_yXKWyGxOZOTZlq0wLJD3a8zJLrlaKODvEf6joUSdEn-zq74kftI0i2iaO7Zb4bvdGXFofwq5tYWakMmXNH3U_UFtmdBYk28NvSERcsT6OiUsE" />  <script> (function(h,o,t,j,a,r){ h.hj=h.hj||function(){(h.hj.q=h.hj.q||[]).push(arguments)}; h._hjSettings={hjid:3915815,hjsv:6}; a=o.getElementsByTagName('head')[0]; r=o.createElement('script');r.async=1; r.src=t+h._hjSettings.hjid+j+h._hjSettings.hjsv; a.appendChild(r); })(window,document,'https://static.hotjar.com/c/hotjar-','.js?sv='); </script>  <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-NLQHVTWH');</script>  </head> <body class="path-node page-node-type-generic">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NLQHVTWH" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="container-xl"> <div class="layout-container row"> <header role="banner" class="container-fluid"> <div class="row"> <nav class="mobile-header col-12 d-block d-xl-none"> <div class="row top"> <div class="utility-menu-wrapper col-12"> <nav class="utility-menu-wrapper"> <ul class="al-menu-utility-menu menu"> <li class="menu-item"> <a href="/connect-with-us#adverse-events-product-complaints" data-drupal-link-system-path="node/24">Report an Adverse Event</a> </li> <li class="menu-item"> <a href="/connect-with-us#msl-locator" data-drupal-link-system-path="node/24">Locate an MSL</a> </li> </ul> </nav> </div> </div> <div class="row bottom"> <div class="left-side col-8"> <a href="/"> <img class="branding" src="/themes/custom/alnylam/assets/dist/images/rnaiscience-logo.svg" alt="RNAiScience logo"/> </a> </div> <div class="right-side col-4"> <a href="/search"> <img class="search-icon" src="/themes/custom/alnylam/assets/dist/images/search.svg" alt="Search" /> </a> <a role="button" class="ham-icon" tabindex="0" href="#"> <img class="ham-icon" src="/themes/custom/alnylam/assets/dist/images/ham.svg" alt="Menu"/> </a> <div class="mobile-menu-expanded d-none"> <div class="menu-wrapper"> <button type="button" class="btn close" tab-index="0" aria-label="close"> <div class='line'></div> <div class='line'></div> </button> <nav class="main-menu-wrapper"> <ul class="al-menu-main menu"> <li class="menu-item"> <a href="/" data-drupal-link-system-path="<front>">Home</a> </li> <li class="menu-item"> <a href="/alnylam-rnai" data-drupal-link-system-path="node/5">Alnylam & RNAi</a> </li> <li class="menu-item"> <a href="/congresses-publications" data-drupal-link-system-path="node/51">Congresses & Publications</a> </li> <li class="menu-item"> <a href="/therapeutic-areas" data-drupal-link-system-path="node/47">Therapeutic Areas</a> </li> <li class="menu-item"> <a href="/our-therapies" data-drupal-link-system-path="node/49">Our Therapies</a> </li> <li class="menu-item"> <a href="/pipeline-clinical-trials" data-drupal-link-system-path="node/50">Pipeline & Clinical Trials</a> </li> <li class="menu-item"> <a href="/connect-with-us" data-drupal-link-system-path="node/24">Connect With Us</a> </li> <li class="menu-item"> <a href="/payer-connect" data-drupal-link-system-path="node/145">Payer Connect</a> </li> </ul> </nav> <nav class="account-menu-wrapper"> <ul class="al-menu-account menu"> <li class="menu-item"> <a href="/user/login" data-drupal-link-system-path="user/login">Log in</a> </li> </ul> </nav> <nav class="signup-menu-wrapper"> <ul class="al-menu-signup menu"> <li class="menu-item"> <a href="/user/register" data-drupal-link-system-path="user/register">Sign Up</a> </li> </ul> </nav> <a href="https://www.alnylam.com" class="ext mobile-menu-logo-link logo-link"> <img class="al-logo" src="/themes/custom/alnylam/assets/dist/images/alnylam-logo-white.svg" alt="Alnylam logo"/> </a> <div class="footer-menu-wrapper"> <nav class="footer-menu-wrapper"> <ul class="al-menu-footer menu"> <li class="menu-item"> <a href="https://alnylampolicies.com/privacy" target="_blank">Privacy Policy</a> </li> <span class="footer-separator"> | </span> <li class="menu-item"> <a href="https://alnylampolicies.com/" target="_blank">Terms of Use</a> </li> </ul> </nav> <span> <span class="footer-separator">|</span> <span> 漏 2024 Alnylam</span> </span> </div> <div class="legal"> <div class="block-content block-content--type-footer-content block-content--9 block-content--view-mode-full"> <div class="block-content__content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This site is intended for US healthcare professionals.<br>漏 2024 Alnylam Pharmaceuticals, Inc. All rights reserved.<br>MED-US-ALL-2400001</p></div> </div> </div> </div> </div> </div> </div> </div> </nav> </div> </header> <div class="region region-highlighted"> <div data-drupal-messages-fallback class="hidden"></div> </div> <main role="main container-fluid"> <a id="main-content" tabindex="-1"></a> <div class="row"> <div class="main-nav d-none col-12 col-xl-3 d-xl-block"> <div class="left-side branding"> <a href="/"> <img src="/themes/custom/alnylam/assets/dist/images/rnaiscience-logo.svg" alt="RNAiScience logo"/> </a> </div> <aside class="layout-sidebar-first" role="complementary"> <div class="top-wrapper"> <nav class="main-menu-wrapper"> <ul class="al-menu-main menu"> <li class="menu-item"> <a href="/" data-drupal-link-system-path="<front>">Home</a> </li> <li class="menu-item"> <a href="/alnylam-rnai" data-drupal-link-system-path="node/5">Alnylam & RNAi</a> </li> <li class="menu-item"> <a href="/congresses-publications" data-drupal-link-system-path="node/51">Congresses & Publications</a> </li> <li class="menu-item"> <a href="/therapeutic-areas" data-drupal-link-system-path="node/47">Therapeutic Areas</a> </li> <li class="menu-item"> <a href="/our-therapies" data-drupal-link-system-path="node/49">Our Therapies</a> </li> <li class="menu-item"> <a href="/pipeline-clinical-trials" data-drupal-link-system-path="node/50">Pipeline & Clinical Trials</a> </li> <li class="menu-item"> <a href="/connect-with-us" data-drupal-link-system-path="node/24">Connect With Us</a> </li> <li class="menu-item"> <a href="/payer-connect" data-drupal-link-system-path="node/145">Payer Connect</a> </li> </ul> </nav> </div> <div class="bottom-wrapper"> <a href="https://www.alnylam.com" class="aside-logo-link logo-link"> <img class="al-logo" src="/themes/custom/alnylam/assets/dist/images/Alnylam-logo.svg" alt="Alnylam logo"/> </a> <nav class="footer-menu-wrapper"> <ul class="al-menu-footer menu"> <li class="menu-item"> <a href="https://alnylampolicies.com/privacy" target="_blank">Privacy Policy</a> </li> <span class="footer-separator"> | </span> <li class="menu-item"> <a href="https://alnylampolicies.com/" target="_blank">Terms of Use</a> </li> </ul> </nav> </div> </footer> </aside> </div> <div class="content-wrapper col-12 col-xl-9"> <div class="row"> <nav class="desktop-header col-12 d-none d-xl-block"> <div class="row"> <div class="right-side col-12"> <div class="search"> <div class="block block-alnylam-search block-alnylam-search-form-block"> <form action="/search" method="get" id="views-exposed-form-search-search-block" accept-charset="UTF-8"> <div class="search-block-input"> <label for="edit-query-block" class="visually-hidden">Search</label> <input id="edit-query-block" name="query" placeholder="Search" data-drupal-selector="edit-query-block" type="text" size="30" maxlength="128" class="form-text" autocomplete="false"> <div class="disclaimer"> <div class="block-content block-content--type-basic block-content--6 block-content--view-mode-full"> <div class="block-content__content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited.</p></div> </div> </div> </div> </div> <div id="edit-actions-block"> <label for="edit-submit-search-block" class="visually-hidden">Submit</label> <input data-drupal-selector="edit-submit-search-block" type="submit" id="edit-submit-search-block" value="" class="button js-form-submit form-submit" aria-label="Submit Search"> </div> </form> </div> </div> <div class="page-links"> <nav class="utility-menu-wrapper"> <ul class="al-menu-utility-menu menu"> <li class="menu-item"> <a href="/connect-with-us#adverse-events-product-complaints" data-drupal-link-system-path="node/24">Report an Adverse Event</a> </li> <li class="menu-item"> <a href="/connect-with-us#msl-locator" data-drupal-link-system-path="node/24">Locate an MSL</a> </li> </ul> </nav> </div> <div class="account-links"> <nav class="account-menu-wrapper"> <ul class="al-menu-account menu"> <li class="menu-item"> <a href="/user/login" data-drupal-link-system-path="user/login">Log in</a> </li> </ul> </nav> <span class="menu-separator">|</span> <nav class="signup-menu-wrapper"> <ul class="al-menu-signup menu"> <li class="menu-item"> <a href="/user/register" data-drupal-link-system-path="user/register">Sign Up</a> </li> </ul> </nav> </div> </div> </div> </nav> </div> <div class="row"> <div class="top-content col-12"> <div class="region region-content"> <div id="block-alnylam-breadcrumbs" class="block block-system block-system-breadcrumb-block"> </div> <div id="block-alnylam-content" class="block block-system block-system-main-block"> <article about="/search" class="node node--type-generic node--promoted node--view-mode-full"> <div class="node__content"> <div class="meta"> </div> <div class="field field--name-field-modules field--type-entity-reference-revisions field--label-hidden field__items"> <div class="bundle-search field__item"> <div class="paragraph paragraph--type--search paragraph--view-mode--default"> <div class="field field--name-field-search-search-view field--type-viewfield field--label-hidden"> <div class="field__item field__item-label-hidden"> <div class="views-element-container"><div class="search view view-search view-id-search view-display-id-search_page_block js-view-dom-id-18a58c5486b3981e4193b997bb9d0d8307c45eaa02a14f913103bdf3aee4b7cf"> <h1> Search Results for <span>"ATTR"</span></h2> </h1> <div class="view-filters search-bar"> <div class="block block-alnylam-search block-alnylam-search-form-page"> <form action="/search" method="get" id="views-exposed-form-search-search-page" accept-charset="UTF-8"> <label for="edit-query-page" class="visually-hidden">Search</label> <input id="edit-query-page" name="query" placeholder="Search RNAiScience" value="amyloidosis" data-drupal-selector="edit-query-page" type="text" size="30" maxlength="128" class="form-text" autocomplete="false"> <div id="edit-actions-page"> <label for="edit-submit-search-page" class="visually-hidden">Submit</label> <input data-drupal-selector="edit-submit-search-page" type="submit" id="edit-submit-search-page" value="" class="button js-form-submit form-submit" aria-label="Submit Search"> </div> </form> </div> </div> <div class="view-header disclaimer"> <div class="block-content block-content--type-basic block-content--8 block-content--view-mode-full"> <div class="block-content__content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Alnylam is committed to providing the healthcare community with balanced, accurate, and high-quality information about our science, therapeutic areas, and products.</p><p>More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited. </p><p>For more information about our FDA-approved therapies, please see the Full Prescribing Information:</p><ul><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">AMVUTTRA庐 (vutrisiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/GIVLAARI-Prescribing-Information.pdf" target="_blank">GIVLAARI庐 (givosiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/ONPATTRO-Prescribing-Information.pdf" target="_blank">ONPATTRO庐 (patisiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/OXLUMO-Prescribing-Information.pdf" target="_blank">OXLUMO庐 (lumasiran)</a></li></ul></div> </div> </div> </div> <div class="view-content results"> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/TTRSC02_MI_Obici_EU-ATTR%202023_HELIOS-A%20PROs_MED-ALL-TTRSC02-2300039.pdf" target="_blank"> RNAi Therapy in ATTRv Amyloidosis with Polyneuropathy (HELIOS-A): Patient-reported Experiences and Preferences </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-08/TTR02_MI_Kumar_ACC_2024_6MWT_Survival.pdf" target="_blank"> Meta-regression analysis of the association between change in six minute walk distance and survival in transthyretin-mediated amyloidosis with cardiomyopathy </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="https://doi.org/10.1007/s40120-023-00522-4" target="_blank">Impact of Vutrisiran on Quality of Life and Physical Function in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy</a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-11/ISPOR-Europe-2024-Poster-Tafamidis-literature-review-Final.pdf" target="_blank"> Likelihood of disease worsening in patients receiving tafamidis for ATTR amyloidosis with cardiomyopathy (ATTR-CM): A targeted literature review </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/TTR02_MI_Karam_ISA_2022_Diagnosis%20of%20ATTR_MED-ALL-TTR02-2200052.pdf" target="_blank"> The Journey to Diagnosis of ATTR Amyloidosis: Burden of Early Disease </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/DZSTATE_MSL_V122I%20Deck_MED-US-DZSTATE-2300034.pdf" target="_blank"> Hereditary ATTR Amyloidosis: A Closer Look at the V122I Variant External </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> <div class="clearfix text-formatted field field--name-field-description field--type-text-long field--label-hidden field__item"><p>V122I is the most common variant of hATTR amyloidosis in the United States and is most prevalent in patients of African American descent. Compared to other variants, patients with the V122I variant experience significant disease burden and poorer outcomes.</p></div> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-06/Gonzalez-Duarte-APOLLO-B-Nfl-14June24-FINAL-OUTPUT.pdf" target="_blank"> Neurofilament Light Chain in ATTR Amyloidosis with Cardiomyopathy: Analysis from the Phase 3 APOLLO-B Study </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/TTR02_MI_Karam_HFSA_2022_Journey%20To%20Diagnosis_MED-ALL-TTR02-2300197.pdf" target="_blank"> The Journey to Diagnosis of Wild-Type ATTR Amyloidosis: A Path with Multisystem Involvement </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-09/HFSA_2024_Poster_ATTR-CM_Taf_RWE_upload.pdf" target="_blank"> Unmet Need in a Contemporary Cohort of Tafamidis-Treated Transthyretin Amyloid Cardiomyopathy Patients </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-05/TTR02_MI_Grogan_ISA_2024_APOLLO-B%20PN%20MSK_MED-ALL-TTR02-2400031.pdf" target="_blank"> History of Polyneuropathy and Musculoskeletal Manifestations in Patients with Transthyretin-Mediated Amyloidosis with Cardiomyopathy in APOLLO-B </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> </div> <div class="pagerer-container"> <div class="pagerer-panes"> <div class="pagerer-left-pane"></div> <div class="pagerer-center-pane"> <nav class="pager pagerer-pager-basic" role="navigation" aria-labelledby="pagination-heading"> <h4 id="pagination-heading" class="visually-hidden">Pagination</h4> <ul class="pager__items js-pager__items"> <li class="pager__item pagerer-prefix"> <span aria-hidden="true" role="presentation"><b>1</b> of 5</span> </li> <li class="pager__item pager__item--next"> <a href="?query=ATTR&page=1" title="Go to next page" rel="next"> <span class="visually-hidden">Next page</span> <span aria-hidden="true"></span> </a> </li> </ul> </nav> </div> <div class="pagerer-right-pane"></div> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-search-footer field--type-text-long field--label-hidden field__item"><p>For further information regarding your request, please <a href="/connect-with-us" data-entity-type="node" data-entity-uuid="14d16229-75d9-400d-b346-fa3db98f1e49" data-entity-substitution="canonical"><strong>connect with us</strong></a> by reaching out to your local Medical Science Liaison or contacting our Medical Information team.</p></div> </div> </div> </div> </div> </article> </div> </div> </div> <footer class="desktop-footer col-12 d-none d-xl-block" role="contentinfo"> <div class="block-content block-content--type-footer-content block-content--9 block-content--view-mode-full"> <div class="block-content__content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This site is intended for US healthcare professionals.<br>漏 2024 Alnylam Pharmaceuticals, Inc. All rights reserved.<br>MED-US-ALL-2400001</p></div> </div> </div> </footer> <footer class="mobile-footer col-12 d-xl-none" role="contentinfo"> <div class="footer-menu-wrapper"> <nav class="footer-menu-wrapper"> <ul class="al-menu-footer menu"> <li class="menu-item"> <a href="https://alnylampolicies.com/privacy" target="_blank">Privacy Policy</a> </li> <span class="footer-separator"> | </span> <li class="menu-item"> <a href="https://alnylampolicies.com/" target="_blank">Terms of Use</a> </li> </ul> </nav> <span> <span class="footer-separator">|</span> <span> 漏 2024 Alnylam</span> </span> </div> <a href="https://www.alnylam.com" class="ext footer-logo-link logo-link"> <img class="al-logo" src="/themes/custom/alnylam/assets/dist/images/alnylam-logo-white.svg" alt="Alnylam logo"/> </a> </footer> </div> </div> </div> </main> <div class="al-modal external-link-modal non-alnylam inactive"> <div class="modal-wrapper"> <div class="block external-link-modal-block"> <div class="branding"> <img src="/themes/custom/alnylam/assets/dist/images/rnai.svg" alt="RNAI Logo" /> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>You are now leaving this site and being directed to a third-party website that is not maintained by Alnylam. Alnylam does not endorse and is not responsible for content or maintenance of third-party websites.</p><p><a class="button continue-button" href="#">Continue</a><a class="button cancel-button" href="#">Cancel</a></p></div> </div> </div> </div> <div class="al-modal external-link-modal primary-alnylam inactive"> <div class="modal-wrapper"> <div class="block external-link-modal-block"> <div class="branding"> <img src="/themes/custom/alnylam/assets/dist/images/rnai.svg" alt="RNAI Logo" /> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>You are now leaving this site and being directed to another Alnylam website.</p><p><a class="button continue-button" href="#">Continue</a><a class="button cancel-button" href="#">Cancel</a></p></div> </div> </div> </div> <div class="al-modal disclaimer-modal inactive"> <div class="modal-wrapper"> <div class="block disclaimer-modal-block"> <div class="branding"> <img src="/themes/custom/alnylam/assets/dist/images/rnai.svg" alt="RNAI Logo" /> </div> <input class="d-none" type="hidden" value="0" id="disclaimer-value" /> <input class="d-none" type="hidden" value="86400000" id="disclaimer-ttl" /> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Intended for US healthcare professionals. This site is intended to provide balanced, evidence-based information to support scientific exchange. It is not intended to provide medical advice or recommendations for clinical practice.</p><p>Information about investigational therapeutics or investigational uses of approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of FDA approval.</p><p>Alnylam does not recommend or suggest use of its products in any manner inconsistent with the approved Prescribing Information.</p><p>Are you a healthcare professional practicing in the United States?</p><p><a class="button hcp-button hcp-button-home" href="#">I confirm I am a US healthcare professional</a></p><p><a class="button hcp-button payer-connect-hcp-button" href="/payer-connect" data-entity-type="node" data-entity-uuid="634243ce-b30b-41b4-82f7-b6ea8dfc7ee4" data-entity-substitution="canonical">I am a US payer or healthcare decision maker</a></p><p><a class="button not-hcp-button" href="#">I am not a US healthcare professional, or a US payer or healthcare decision maker</a></p><p><a class="rep-button" href="#">I am an Alnylam Team Member</a></p></div> </div> </div> </div> <div class="al-modal login-modal inactive"> <div class="block modal-block"> <span class="close">X</span> <div class="modal-title"> <span style="color:#143a66; size:20;">Don't miss out!</span> </div><div class="modal-content"> <p>Sign in to bookmark information and create your personal library</p><p><a class="button" href="/user/login">Log in</a></p><p>Don't have an account? <a href="/user/register"><strong>Sign up</strong></a></p> </div> </div> </div> <div class="modal-background inactive"></div> </div> </div> </div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/23","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en","currentQuery":{"query":"ATTR"}},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxFjlsOwjAMBC8UkiOhDTFpqPOQ3UDL6WlRKD8rz0heLbhsjOw8lAwGRK4efOHkBbKdOpMqIukpSg1kblVovySD05sMrQunMrsgvYHtQHNnRHeEPfCKB1bT9jIhcbnzkhoK7UYQBW3S3__f2F5a95x0omB004XG6meil7pv2lxDZ_oAcSxSwQ","theme":"alnylam","theme_token":null},"ajaxTrustedUrl":[],"data":{"extlink":{"extTarget":true,"extTargetNoOverride":true,"extNofollow":false,"extNoreferrer":false,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":false,"extExclude":"","extInclude":"","extCssExclude":"","extCssExplicit":"","extAlert":false,"extAlertText":"This link will take you to an external web site. We are not responsible for their content. Click Me!","mailtoClass":"0","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"append","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"user":{"uid":0,"permissionsHash":"af669ad7e8d0506788efb80fe142a694aa0101197c5f2204180a5ca90a7fdc78"}}</script> <script src="/sites/default/files/js/js_IKxMJs_sp9nX1TA7XxsDxk2ofdAJXNaqSwdpAgDd9y4.js?scope=footer&delta=0&language=en&theme=alnylam&include=eJxLzMmrzEnM1U_PyU9KzNHNyUwqSiyq1EmtKMnJzMvWTykqLUjM0YNyddJyEtP1QYQeiBufmJVYAQBDdxku"></script> <script type="module" src="https://d1mu6oy21or6o2.cloudfront.net/v1.0/bundle.js"></script> <mic-mei-component client-id="7755122c-57d1-4b39-80a8-d1fb00e71fc6" class="mic-mei-component-custom" config-name="Alnylam_Web_Component_Template" style="--mei-font-family:Satoshi-Regular; --mei-header-font-size: 2rem; --mei-subheader-font-size: 1.5rem; --mei-preamble-font-size: 0.8em; --mei-footer-font-size: 0.8em; --mei-primary-color:#4e586a; --mei-header-color:#143a66; --mei-subheader-color:#0099dc; --mei-button-color:#005b85; --mei-border: 0.01rem solid #153a64; --mei-button-text-color: #FFF; --mei-icon-closed: url(/themes/custom/alnylam/images/icons/AskMedical.png); --mei-icon-expanded: url(/themes/custom/alnylam/images/icons/AskMedical.png);"></mic-mei-component> </body> </html>

CINXE.COM

Search|Resources to understand how Alnylam鈥檚 RNAi-based medicines work