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class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">William Dupont</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="William" data-follow-user-id="42330984" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden 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Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42330984" href="https://www.academia.edu/Documents/in/Optical_fiber_sensors"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/WilliamDupont4","location":"/WilliamDupont4","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/WilliamDupont4","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Optical fiber sensors"]}" data-trace="false" 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data-trace="false" data-dom-id="Pill-react-component-6eaa09b4-f01c-417b-9746-d6f7e6d570e8"></div> <div id="Pill-react-component-6eaa09b4-f01c-417b-9746-d6f7e6d570e8"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by William Dupont</h3></div><div class="js-work-strip profile--work_container" data-work-id="21145147"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/21145147/The_impact_of_peer_management_on_test_ordering_behavior"><img alt="Research paper thumbnail of The impact of peer management on test-ordering behavior" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/21145147/The_impact_of_peer_management_on_test_ordering_behavior">The impact of peer management on test-ordering behavior</a></div><div class="wp-workCard_item"><span>Annals of internal medicine</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Laboratory testing of hospitalized patients, although essential, can be expensive and sometimes e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Laboratory testing of hospitalized patients, although essential, can be expensive and sometimes excessive. Attempts to reduce unnecessary testing have often been difficult to implement or sustain. Use of peer management through a resource utilization committee (RUC) to favorably modify test-ordering behavior in a large academic medical center. Interrupted time-series study. Medical center with inpatient care provider order entry (CPOE) system and database of ordered tests. Predominantly housestaff physicians but all clinical staff (attending physicians, housestaff, medical students, nurses, advance practice nurses, and other clinical staff) at Vanderbilt University Hospital who used CPOE systems. The RUC analyzed the ordering habits of providers during previous years and made 2 interventions by modifying software for the CPOE system. The committee first initiated a daily prompt in the system that asked providers whether they wanted to discontinue tests scheduled beyond 72 hours. Aft...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145147"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145147"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145147; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145147]").text(description); $(".js-view-count[data-work-id=21145147]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145147; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145147']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145147, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145147]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145147,"title":"The impact of peer management on test-ordering behavior","translated_title":"","metadata":{"abstract":"Laboratory testing of hospitalized patients, although essential, can be expensive and sometimes excessive. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145145"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21145145/Innovative_Analyses_Support_a_Role_for_DNA_Damage_and_an_Aberrant_Cell_Cycle_in_Myelodysplastic_Syndrome_Pathogenesis"><img alt="Research paper thumbnail of Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/41735206/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21145145/Innovative_Analyses_Support_a_Role_for_DNA_Damage_and_an_Aberrant_Cell_Cycle_in_Myelodysplastic_Syndrome_Pathogenesis">Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis</a></div><div class="wp-workCard_item"><span>Bone Marrow Research</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="faf1bbaec97f52c26246266c44d045f7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735206,"asset_id":21145145,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41735206/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145145"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145145"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145145; 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src="https://attachments.academia-assets.com/41735210/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21145139/Laboratory_and_epidemiologic_assessment_of_a_recent_influenza_B_outbreak">Laboratory and epidemiologic assessment of a recent influenza B outbreak</a></div><div class="wp-workCard_item"><span>Journal of Medical Virology</span><span>, 1988</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bb1c659dc0dac8fa518ee6df96144ece" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735210,"asset_id":21145139,"asset_type":"Work","button_location":"profile"}" 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145137"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/21145137/Evaluation_of_a_New_Highly_Purified_Pertussis_Vaccine_in_Infants_and_Children"><img alt="Research paper thumbnail of Evaluation of a New Highly Purified Pertussis Vaccine in Infants and Children" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/21145137/Evaluation_of_a_New_Highly_Purified_Pertussis_Vaccine_in_Infants_and_Children">Evaluation of a New Highly Purified Pertussis Vaccine in Infants and Children</a></div><div class="wp-workCard_item"><span>Journal of Infectious Diseases</span><span>, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purified acellular pertussis vaccine (12.5 micrograms of lymphocytosis promoting factor [LPF] and...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purified acellular pertussis vaccine (12.5 micrograms of lymphocytosis promoting factor [LPF] and 12.5 micrograms of filamentous hemagglutinin [FHA]) was compared with conventional pertussis vaccine in a randomized double-blind study involving 40 children aged 4-6 y, 40 children aged 18-24 mo, and 50 infants. Increases in antibody were significantly greater among recipients of acellular vaccine than among recipients of conventional vaccine for antibodies to LPF in all age groups and for antibodies to FHA in infants and children aged 4-6 y; the increase in FHA antibody was also greater with acellular vaccine among children aged 18-24 mo but not significantly so. Compared with conventional vaccine, acellular vaccine was significantly associated with reduced frequency of leg pain and fretfulness at all ages and less frequent fever and anorexia at some ages. The reduced reaction rates and comparable or enhanced immunogenicity of the acellular vaccine make it an attractive candidate for larger field trials, particularly among infants.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145137"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145137"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145137; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145137]").text(description); $(".js-view-count[data-work-id=21145137]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145137; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145137']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145137, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145137]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145137,"title":"Evaluation of a New Highly Purified Pertussis Vaccine in Infants and Children","translated_title":"","metadata":{"abstract":"Purified acellular pertussis vaccine (12.5 micrograms of lymphocytosis promoting factor [LPF] and 12.5 micrograms of filamentous hemagglutinin [FHA]) was compared with conventional pertussis vaccine in a randomized double-blind study involving 40 children aged 4-6 y, 40 children aged 18-24 mo, and 50 infants. Increases in antibody were significantly greater among recipients of acellular vaccine than among recipients of conventional vaccine for antibodies to LPF in all age groups and for antibodies to FHA in infants and children aged 4-6 y; the increase in FHA antibody was also greater with acellular vaccine among children aged 18-24 mo but not significantly so. Compared with conventional vaccine, acellular vaccine was significantly associated with reduced frequency of leg pain and fretfulness at all ages and less frequent fever and anorexia at some ages. The reduced reaction rates and comparable or enhanced immunogenicity of the acellular vaccine make it an attractive candidate for larger field trials, particularly among infants.","publication_date":{"day":null,"month":null,"year":1989,"errors":{}},"publication_name":"Journal of Infectious Diseases"},"translated_abstract":"Purified acellular pertussis vaccine (12.5 micrograms of lymphocytosis promoting factor [LPF] and 12.5 micrograms of filamentous hemagglutinin [FHA]) was compared with conventional pertussis vaccine in a randomized double-blind study involving 40 children aged 4-6 y, 40 children aged 18-24 mo, and 50 infants. Increases in antibody were significantly greater among recipients of acellular vaccine than among recipients of conventional vaccine for antibodies to LPF in all age groups and for antibodies to FHA in infants and children aged 4-6 y; the increase in FHA antibody was also greater with acellular vaccine among children aged 18-24 mo but not significantly so. Compared with conventional vaccine, acellular vaccine was significantly associated with reduced frequency of leg pain and fretfulness at all ages and less frequent fever and anorexia at some ages. The reduced reaction rates and comparable or enhanced immunogenicity of the acellular vaccine make it an attractive candidate for larger field trials, particularly among infants.","internal_url":"https://www.academia.edu/21145137/Evaluation_of_a_New_Highly_Purified_Pertussis_Vaccine_in_Infants_and_Children","translated_internal_url":"","created_at":"2016-01-29T07:44:39.998-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141438,"work_id":21145137,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288784,"email":"e***d@ariessun.com","display_order":0,"name":"Kathryn Edwards","title":"Evaluation of a New Highly Purified Pertussis Vaccine in Infants and Children"}],"downloadable_attachments":[],"slug":"Evaluation_of_a_New_Highly_Purified_Pertussis_Vaccine_in_Infants_and_Children","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42330984,"first_name":"William","middle_initials":null,"last_name":"Dupont","page_name":"WilliamDupont4","domain_name":"independent","created_at":"2016-01-29T07:41:55.441-08:00","display_name":"William Dupont","url":"https://independent.academia.edu/WilliamDupont4"},"attachments":[],"research_interests":[{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":210665,"name":"Infectious","url":"https://www.academia.edu/Documents/in/Infectious"},{"id":543531,"name":"Drug evaluation","url":"https://www.academia.edu/Documents/in/Drug_evaluation"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine"},{"id":965028,"name":"Cell free System","url":"https://www.academia.edu/Documents/in/Cell_free_System"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145135"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/21145135/The_high_burden_of_pneumonia_on_US_emergency_departments_during_the_2009_influenza_pandemic"><img alt="Research paper thumbnail of The high burden of pneumonia on US emergency departments during the 2009 influenza pandemic" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/21145135/The_high_burden_of_pneumonia_on_US_emergency_departments_during_the_2009_influenza_pandemic">The high burden of pneumonia on US emergency departments during the 2009 influenza pandemic</a></div><div class="wp-workCard_item"><span>Journal of Infection</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winte...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winter season provided a unique opportunity to evaluate the association between influenza and pneumonia incidence. We sought to quantify the impact of the 2009 pandemic on the incidence of emergency department (ED) visits for pneumonia in the United States (US). Using the Nationwide Emergency Department Survey, we estimated monthly counts and rates of excess all-cause pneumonia ED visits in the US attributable to the pandemic by comparing observed pneumonia ED visits during the pandemic (April 2009-March 2010) to expected values modeled from the three prior years. The pandemic was associated with an excess of 180,560 pneumonia ED visits or 0.59 excess pneumonia visits per 1000 US population (95% confidence interval: 0.55, 0.62). These excess visits accounted for 7.0% of all pneumonia ED visits during the pandemic year. The greatest excess occurred during months with highest influenza activity (September-November 2009). Persons aged &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;65 years accounted for 94% of the excess pneumonia visits. ED visits for pneumonia increased substantially during the 2009 pandemic, especially during peak influenza activity, suggesting a strong association between influenza activity and pneumonia incidence during the pandemic period.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145135"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145135"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145135; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145135]").text(description); $(".js-view-count[data-work-id=21145135]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145135; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145135']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145135, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145135]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145135,"title":"The high burden of pneumonia on US emergency departments during the 2009 influenza pandemic","translated_title":"","metadata":{"abstract":"During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winter season provided a unique opportunity to evaluate the association between influenza and pneumonia incidence. We sought to quantify the impact of the 2009 pandemic on the incidence of emergency department (ED) visits for pneumonia in the United States (US). Using the Nationwide Emergency Department Survey, we estimated monthly counts and rates of excess all-cause pneumonia ED visits in the US attributable to the pandemic by comparing observed pneumonia ED visits during the pandemic (April 2009-March 2010) to expected values modeled from the three prior years. The pandemic was associated with an excess of 180,560 pneumonia ED visits or 0.59 excess pneumonia visits per 1000 US population (95% confidence interval: 0.55, 0.62). These excess visits accounted for 7.0% of all pneumonia ED visits during the pandemic year. The greatest excess occurred during months with highest influenza activity (September-November 2009). Persons aged \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;65 years accounted for 94% of the excess pneumonia visits. ED visits for pneumonia increased substantially during the 2009 pandemic, especially during peak influenza activity, suggesting a strong association between influenza activity and pneumonia incidence during the pandemic period.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of Infection"},"translated_abstract":"During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winter season provided a unique opportunity to evaluate the association between influenza and pneumonia incidence. We sought to quantify the impact of the 2009 pandemic on the incidence of emergency department (ED) visits for pneumonia in the United States (US). 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ED visits for pneumonia increased substantially during the 2009 pandemic, especially during peak influenza activity, suggesting a strong association between influenza activity and pneumonia incidence during the pandemic period.","internal_url":"https://www.academia.edu/21145135/The_high_burden_of_pneumonia_on_US_emergency_departments_during_the_2009_influenza_pandemic","translated_internal_url":"","created_at":"2016-01-29T07:44:39.758-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141498,"work_id":21145135,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288794,"email":"z***u@math.uci.edu","display_order":0,"name":"Yuwei Zhu","title":"The high burden of pneumonia on US emergency departments during the 2009 influenza pandemic"}],"downloadable_attachments":[],"slug":"The_high_burden_of_pneumonia_on_US_emergency_departments_during_the_2009_influenza_pandemic","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42330984,"first_name":"William","middle_initials":null,"last_name":"Dupont","page_name":"WilliamDupont4","domain_name":"independent","created_at":"2016-01-29T07:41:55.441-08:00","display_name":"William Dupont","url":"https://independent.academia.edu/WilliamDupont4"},"attachments":[],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":109739,"name":"Infection","url":"https://www.academia.edu/Documents/in/Infection"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":594653,"name":"Pandemics","url":"https://www.academia.edu/Documents/in/Pandemics"},{"id":649451,"name":"Seasons","url":"https://www.academia.edu/Documents/in/Seasons"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145132"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21145132/Proteomic_analysis_of_osteogenic_sarcoma_association_of_tumour_necrosis_factor_with_poor_prognosis"><img alt="Research paper thumbnail of Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis" class="work-thumbnail" src="https://attachments.academia-assets.com/41735223/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21145132/Proteomic_analysis_of_osteogenic_sarcoma_association_of_tumour_necrosis_factor_with_poor_prognosis">Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis</a></div><div class="wp-workCard_item"><span>International Journal of Experimental Pathology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="380a3f92c86fb1d343cd0959cf4d81e4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735223,"asset_id":21145132,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41735223/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145132"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145132"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145132; 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Molecular signatures that predict pulmonary metastasis from primary osteogenic sarcoma and identify those patients at risk would be clinically useful as prognostic markers. Protein expression profiles of two clonally related murine osteogenic sarcoma cell lines with low (K12) and high (K7M2) metastatic potential were compared using two different proteomic technologies, twodimensional difference gel electrophoresis and cell profiling by matrix-assisted laser desorption ⁄ ionization mass spectrometry. Interrogation of a molecular pathways network database suggested several additional candidate molecules that potentially predict metastatic potential of primary osteogenic sarcoma. Two such proteins, macrophage migration inhibitory factor and tumour necrosis factor were selected for further validation studies. Western blots confirmed increased expression of both cytokines in K7M2 cells compared to K12 cells. Levels of migration inhibitory factor and tumour necrosis factor were semi-quantitatively measured in human osteogenic sarcoma samples by immunohistochemistry and were correlated with clinicopathologic parameters and patient outcomes. Multivariate survival analysis demonstrated that tumour necrosis factor expression in chemotherapy naïve osteogenic sarcoma is an independent prognostic factor for overall and metastasis-free survival. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20731308"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20731308/Effects_of_ibuprofen_on_the_physiology_and_survival_of_hypothermic_sepsis"><img alt="Research paper thumbnail of Effects of ibuprofen on the physiology and survival of hypothermic sepsis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20731308/Effects_of_ibuprofen_on_the_physiology_and_survival_of_hypothermic_sepsis">Effects of ibuprofen on the physiology and survival of hypothermic sepsis</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://vanderbilthealth.academia.edu/BrianChristman">Brian Christman</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/WilliamDupont4">William Dupont</a></span></div><div class="wp-workCard_item"><span>Critical Care Medicine</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The objective was to compare the clinical and physiologic characteristics of febrile septic patie...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The objective was to compare the clinical and physiologic characteristics of febrile septic patients with hypothermic septic patients; and to examine plasma levels of cytokines tumor necrosis factor alpha (TNF-alpha and interleukin 6 (IL-6) and the lipid mediators thromboxane B2 (TxB2) and prostacyclin in hypothermic septic patients in comparison with febrile patients. Most importantly, we wanted to report the effect of ibuprofen treatment on vital signs, organ failure, and mortality in hypothermic sepsis. The study was performed in the intensive care units (ICUs) of seven clinical centers in the United States and Canada. Four hundred fifty-five patients admitted to the ICU who met defined criteria for severe sepsis and were suspected of having a serious infection. Ibuprofen at a dose of 10 mg/kg (maximum 800 mg) was administered intravenously over 30 to 60 mins every 6 hrs for eight doses vs. placebo (glycine buffer vehicle). Forty-four (10%) septic patients met criteria for hypothermia and 409 were febrile. The mortality rate was significantly higher in hypothermic patients, 70% vs. 35% for febrile patients. At study entry, urinary metabolites of TxB2, prostacyclin, and serum levels of TNF-alpha and IL-6 were significantly elevated in hypothermic patients compared with febrile patients. In hypothermic patients treated with ibuprofen, there was a trend toward an increased number of days free of major organ system failures and a significant reduction in the 30-day mortality rate from 90% (18/20 placebo-treated patients) to 54% (13/24 ibuprofen-treated patients). Hypothermic sepsis has an incidence of approximately 10% and an untreated mortality twice that of severe sepsis presenting with fever. When compared with febrile patients, the hypothermic group has an amplified response with respect to cytokines TNF-alpha and IL-6 and lipid mediators TxB2 and prostacyclin. 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20731306/Hypoproteinemia_predicts_acute_respiratory_distress_syndrome_development_weight_gain_and_death_in_patients_with_sepsis"><img alt="Research paper thumbnail of Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20731306/Hypoproteinemia_predicts_acute_respiratory_distress_syndrome_development_weight_gain_and_death_in_patients_with_sepsis">Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://vanderbilthealth.academia.edu/BrianChristman">Brian Christman</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/WilliamDupont4">William Dupont</a></span></div><div class="wp-workCard_item"><span>Critical Care Medicine</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Starling&amp;amp;amp;#39;s equation indicates that reduced oncotic pressure gradients will favor ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Starling&amp;amp;amp;#39;s equation indicates that reduced oncotic pressure gradients will favor edema formation, and the current consensus definition of acute respiratory distress syndrome (ARDS) excludes only the hydrostatic pressure contribution. We hypothesized that low serum total protein levels might correlate with the likelihood of ARDS in at-risk patients because serum total protein is the chief determinant of oncotic pressure in humans. Regression analysis to compare outcomes in patients with low serum total protein levels with outcomes in patients with normal serum total protein levels with respect to weight change, development of ARDS, and mortality. Intensive care units (ICUs) of seven clinical centers in North America. A total of 455 ICU patients who met consensus criteria for severe sepsis (178 of whom developed ARDS) from a recently completed prospective clinical trial. None. We found that 92% of the patients developing ARDS had low or borderline serum total protein levels (&amp;amp;amp;lt;6 g/dL). Logistic and multiple regression analyses confirmed that of 18 clinical variables, initial serum total protein level and protein change over time were the most statistically significant predictors of weight gain, prolonged mechanical ventilation, ARDS development, and mortality in the study population. This correlation remained significant after adjustment for the other major predictors of outcome present at baseline (ie, Acute Physiology and Chronic Health Evaluation II score). Hypoproteinemia is significantly correlated with fluid retention and weight gain, development of ARDS and poor respiratory outcome, and mortality in patients with sepsis. Prospective, randomized trials of serum protein manipulation are needed to establish whether there is a cause-effect relationship to this association.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20731306"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20731306"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20731306; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20731306]").text(description); $(".js-view-count[data-work-id=20731306]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20731306; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20731306']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20731306, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20731306]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20731306,"title":"Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis","translated_title":"","metadata":{"abstract":"Starling\u0026amp;amp;amp;#39;s equation indicates that reduced oncotic pressure gradients will favor edema formation, and the current consensus definition of acute respiratory distress syndrome (ARDS) excludes only the hydrostatic pressure contribution. We hypothesized that low serum total protein levels might correlate with the likelihood of ARDS in at-risk patients because serum total protein is the chief determinant of oncotic pressure in humans. Regression analysis to compare outcomes in patients with low serum total protein levels with outcomes in patients with normal serum total protein levels with respect to weight change, development of ARDS, and mortality. Intensive care units (ICUs) of seven clinical centers in North America. A total of 455 ICU patients who met consensus criteria for severe sepsis (178 of whom developed ARDS) from a recently completed prospective clinical trial. None. We found that 92% of the patients developing ARDS had low or borderline serum total protein levels (\u0026amp;amp;amp;lt;6 g/dL). Logistic and multiple regression analyses confirmed that of 18 clinical variables, initial serum total protein level and protein change over time were the most statistically significant predictors of weight gain, prolonged mechanical ventilation, ARDS development, and mortality in the study population. This correlation remained significant after adjustment for the other major predictors of outcome present at baseline (ie, Acute Physiology and Chronic Health Evaluation II score). Hypoproteinemia is significantly correlated with fluid retention and weight gain, development of ARDS and poor respiratory outcome, and mortality in patients with sepsis. Prospective, randomized trials of serum protein manipulation are needed to establish whether there is a cause-effect relationship to this association.","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Critical Care Medicine"},"translated_abstract":"Starling\u0026amp;amp;amp;#39;s equation indicates that reduced oncotic pressure gradients will favor edema formation, and the current consensus definition of acute respiratory distress syndrome (ARDS) excludes only the hydrostatic pressure contribution. We hypothesized that low serum total protein levels might correlate with the likelihood of ARDS in at-risk patients because serum total protein is the chief determinant of oncotic pressure in humans. Regression analysis to compare outcomes in patients with low serum total protein levels with outcomes in patients with normal serum total protein levels with respect to weight change, development of ARDS, and mortality. Intensive care units (ICUs) of seven clinical centers in North America. A total of 455 ICU patients who met consensus criteria for severe sepsis (178 of whom developed ARDS) from a recently completed prospective clinical trial. None. We found that 92% of the patients developing ARDS had low or borderline serum total protein levels (\u0026amp;amp;amp;lt;6 g/dL). Logistic and multiple regression analyses confirmed that of 18 clinical variables, initial serum total protein level and protein change over time were the most statistically significant predictors of weight gain, prolonged mechanical ventilation, ARDS development, and mortality in the study population. This correlation remained significant after adjustment for the other major predictors of outcome present at baseline (ie, Acute Physiology and Chronic Health Evaluation II score). Hypoproteinemia is significantly correlated with fluid retention and weight gain, development of ARDS and poor respiratory outcome, and mortality in patients with sepsis. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145125"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21145125/Adenomyoepithelioma"><img alt="Research paper thumbnail of Adenomyoepithelioma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21145125/Adenomyoepithelioma">Adenomyoepithelioma</a></div><div class="wp-workCard_item"><span>The American Journal of Surgical Pathology</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145125]").text(description); $(".js-view-count[data-work-id=21145125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145125, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Although regarded by some as a norma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hippus is a prominent, repetitive oscillation of the pupils. Although regarded by some as a normal variant of pupillary unrest, the clinical importance of hippus has not been investigated systematically in hospitalized patients. We conducted a retrospective cohort study of 117 hospitalized patients demonstrating hippus. To mitigate observer bias, 486 control patients were selected using 2 adjacent admissions by the same attending physician before and after each index case. The primary outcomes were mortality during the admission and within 30 days of discharge. Patients with bedside hippus were more likely to die within 30 days of observation (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.00005). Independent risk factors for death by 30 days were altered mental status (odds ratio [OR] 4.11; 95% confidence interval [CI], 2.05-8.25, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), hippus (OR 2.99; 95% CI, 1.46-6.11, P = .003), cirrhosis (P = .029), and renal disease (P = .054); angiotensin-system inhibitors were protective (P = .012). Patients with hippus were more likely to have altered mental status (OR 11.23; 95% CI, 6.27-20.09, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), a history of trauma (OR 3.76; 95% CI, 1.65-8.59, P = .002), cirrhosis (P = .038), renal disease (P = .051), and a history of using iron supplements (P = .016). The recognition of hippus in hospitalized patients is a clinically important predictor of early mortality.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145124"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145124"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145124; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145124]").text(description); $(".js-view-count[data-work-id=21145124]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145124; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145124']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145124, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145124]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145124,"title":"Increased Hospital Mortality in Patients with Bedside Hippus","translated_title":"","metadata":{"abstract":"Hippus is a prominent, repetitive oscillation of the pupils. Although regarded by some as a normal variant of pupillary unrest, the clinical importance of hippus has not been investigated systematically in hospitalized patients. We conducted a retrospective cohort study of 117 hospitalized patients demonstrating hippus. To mitigate observer bias, 486 control patients were selected using 2 adjacent admissions by the same attending physician before and after each index case. The primary outcomes were mortality during the admission and within 30 days of discharge. Patients with bedside hippus were more likely to die within 30 days of observation (P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.00005). Independent risk factors for death by 30 days were altered mental status (odds ratio [OR] 4.11; 95% confidence interval [CI], 2.05-8.25, P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), hippus (OR 2.99; 95% CI, 1.46-6.11, P = .003), cirrhosis (P = .029), and renal disease (P = .054); angiotensin-system inhibitors were protective (P = .012). Patients with hippus were more likely to have altered mental status (OR 11.23; 95% CI, 6.27-20.09, P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), a history of trauma (OR 3.76; 95% CI, 1.65-8.59, P = .002), cirrhosis (P = .038), renal disease (P = .051), and a history of using iron supplements (P = .016). The recognition of hippus in hospitalized patients is a clinically important predictor of early mortality.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"The American Journal of Medicine"},"translated_abstract":"Hippus is a prominent, repetitive oscillation of the pupils. Although regarded by some as a normal variant of pupillary unrest, the clinical importance of hippus has not been investigated systematically in hospitalized patients. We conducted a retrospective cohort study of 117 hospitalized patients demonstrating hippus. To mitigate observer bias, 486 control patients were selected using 2 adjacent admissions by the same attending physician before and after each index case. The primary outcomes were mortality during the admission and within 30 days of discharge. Patients with bedside hippus were more likely to die within 30 days of observation (P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.00005). Independent risk factors for death by 30 days were altered mental status (odds ratio [OR] 4.11; 95% confidence interval [CI], 2.05-8.25, P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), hippus (OR 2.99; 95% CI, 1.46-6.11, P = .003), cirrhosis (P = .029), and renal disease (P = .054); angiotensin-system inhibitors were protective (P = .012). Patients with hippus were more likely to have altered mental status (OR 11.23; 95% CI, 6.27-20.09, P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), a history of trauma (OR 3.76; 95% CI, 1.65-8.59, P = .002), cirrhosis (P = .038), renal disease (P = .051), and a history of using iron supplements (P = .016). The recognition of hippus in hospitalized patients is a clinically important predictor of early mortality.","internal_url":"https://www.academia.edu/21145124/Increased_Hospital_Mortality_in_Patients_with_Bedside_Hippus","translated_internal_url":"","created_at":"2016-01-29T07:44:38.552-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141426,"work_id":21145124,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288783,"email":"e***n@mcmail.vanderbilt.edu","display_order":0,"name":"Eric Neilson","title":"Increased Hospital Mortality in Patients with Bedside Hippus"}],"downloadable_attachments":[],"slug":"Increased_Hospital_Mortality_in_Patients_with_Bedside_Hippus","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42330984,"first_name":"William","middle_initials":null,"last_name":"Dupont","page_name":"WilliamDupont4","domain_name":"independent","created_at":"2016-01-29T07:41:55.441-08:00","display_name":"William Dupont","url":"https://independent.academia.edu/WilliamDupont4"},"attachments":[],"research_interests":[{"id":24377,"name":"Mortality","url":"https://www.academia.edu/Documents/in/Mortality"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":143507,"name":"Eye Movements","url":"https://www.academia.edu/Documents/in/Eye_Movements"},{"id":174781,"name":"Oscillations","url":"https://www.academia.edu/Documents/in/Oscillations"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":437772,"name":"Odds ratio","url":"https://www.academia.edu/Documents/in/Odds_ratio"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":901284,"name":"Hospital Mortality","url":"https://www.academia.edu/Documents/in/Hospital_Mortality"},{"id":1180098,"name":"Renal disease","url":"https://www.academia.edu/Documents/in/Renal_disease"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145123"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/21145123/An_Expressed_Retrogene_of_the_Master_Embryonic_Stem_Cell_Gene_POU5F1_Is_Associated_with_Prostate_Cancer_Susceptibility"><img alt="Research paper thumbnail of An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/21145123/An_Expressed_Retrogene_of_the_Master_Embryonic_Stem_Cell_Gene_POU5F1_Is_Associated_with_Prostate_Cancer_Susceptibility">An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility</a></div><div class="wp-workCard_item"><span>The American Journal of Human Genetics</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Genetic association studies of prostate and other cancers have identified a major risk locus at c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24. Several independent risk variants at this locus alter transcriptional regulatory elements, but an affected gene and mechanism for cancer predisposition have remained elusive. The retrogene POU5F1B within the locus has a preserved open reading frame encoding a homolog of the master embryonic stem cell transcription factor Oct4. We find that 8q24 risk alleles are expression quantitative trait loci correlated with reduced expression of POU5F1B in prostate tissue and that predicted deleterious POU5F1B missense variants are also associated with risk of transformation. POU5F1 is known to be self-regulated by the encoded Oct4 transcription factor. We further observe that POU5F1 expression is directly correlated with POU5F1B expression. Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145123"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145123"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145123; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145123]").text(description); $(".js-view-count[data-work-id=21145123]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145123; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145123']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145123, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145123]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145123,"title":"An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility","translated_title":"","metadata":{"abstract":"Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24. Several independent risk variants at this locus alter transcriptional regulatory elements, but an affected gene and mechanism for cancer predisposition have remained elusive. The retrogene POU5F1B within the locus has a preserved open reading frame encoding a homolog of the master embryonic stem cell transcription factor Oct4. We find that 8q24 risk alleles are expression quantitative trait loci correlated with reduced expression of POU5F1B in prostate tissue and that predicted deleterious POU5F1B missense variants are also associated with risk of transformation. POU5F1 is known to be self-regulated by the encoded Oct4 transcription factor. We further observe that POU5F1 expression is directly correlated with POU5F1B expression. Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"The American Journal of Human Genetics"},"translated_abstract":"Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24. Several independent risk variants at this locus alter transcriptional regulatory elements, but an affected gene and mechanism for cancer predisposition have remained elusive. The retrogene POU5F1B within the locus has a preserved open reading frame encoding a homolog of the master embryonic stem cell transcription factor Oct4. We find that 8q24 risk alleles are expression quantitative trait loci correlated with reduced expression of POU5F1B in prostate tissue and that predicted deleterious POU5F1B missense variants are also associated with risk of transformation. POU5F1 is known to be self-regulated by the encoded Oct4 transcription factor. We further observe that POU5F1 expression is directly correlated with POU5F1B expression. Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer.","internal_url":"https://www.academia.edu/21145123/An_Expressed_Retrogene_of_the_Master_Embryonic_Stem_Cell_Gene_POU5F1_Is_Associated_with_Prostate_Cancer_Susceptibility","translated_internal_url":"","created_at":"2016-01-29T07:44:38.282-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141480,"work_id":21145123,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288788,"email":"j***3@sbcglobal.net","display_order":0,"name":"J. Smith","title":"An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility"},{"id":14141483,"work_id":21145123,"tagging_user_id":42330984,"tagged_user_id":52027165,"co_author_invite_id":566604,"email":"s***g@vanderbilt.edu","display_order":4194304,"name":"Sam Chang","title":"An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility"}],"downloadable_attachments":[],"slug":"An_Expressed_Retrogene_of_the_Master_Embryonic_Stem_Cell_Gene_POU5F1_Is_Associated_with_Prostate_Cancer_Susceptibility","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42330984,"first_name":"William","middle_initials":null,"last_name":"Dupont","page_name":"WilliamDupont4","domain_name":"independent","created_at":"2016-01-29T07:41:55.441-08:00","display_name":"William Dupont","url":"https://independent.academia.edu/WilliamDupont4"},"attachments":[],"research_interests":[{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":174592,"name":"Embryonic Stem Cells","url":"https://www.academia.edu/Documents/in/Embryonic_Stem_Cells"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":317801,"name":"Cell nucleus","url":"https://www.academia.edu/Documents/in/Cell_nucleus"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":547589,"name":"Quantitative Trait Loci","url":"https://www.academia.edu/Documents/in/Quantitative_Trait_Loci"},{"id":577933,"name":"Genetic variation","url":"https://www.academia.edu/Documents/in/Genetic_variation"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145122"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21145122/Optimizing_Personalized_Bone_Marrow_Testing_Using_an_Evidence_Based_Interdisciplinary_Team_Approach"><img alt="Research paper thumbnail of Optimizing Personalized Bone Marrow Testing Using an Evidence-Based, Interdisciplinary Team Approach" class="work-thumbnail" src="https://attachments.academia-assets.com/41735199/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21145122/Optimizing_Personalized_Bone_Marrow_Testing_Using_an_Evidence_Based_Interdisciplinary_Team_Approach">Optimizing Personalized Bone Marrow Testing Using an Evidence-Based, Interdisciplinary Team Approach</a></div><div class="wp-workCard_item"><span>American Journal of Clinical Pathology</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="39a271093fb68eb824ba0c5903499567" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735199,"asset_id":21145122,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41735199/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145122"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145122"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145122; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145122]").text(description); $(".js-view-count[data-work-id=21145122]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145122; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145122']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145122, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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However, without evidence-based standards, there is over-utilization of testing that complicates patient care, diminishes quality, and increases costs. To address this, we implemented the diagnostic management team (DMT), a multi-disciplinary system for development and deployment of diagnostic testing guidelines for hematologic malignancies. The team created evidence-based standard ordering protocols (SOPs) for cytogenetic and molecular testing that were applied by pathologists to bone marrow biopsies on adult patients. Testing on 780 biopsies performed during the 6 months before SOP implementation was compared with 1,806 biopsies performed during the subsequent 12 months. After implementation, there were significant decreases in tests discordant with SOPs, omitted tests, and the estimated cost of testing to payers. The fraction of positive tests increased. Clinicians reported acceptance of the new procedures and perceived time savings. 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href="https://independent.academia.edu/EdwardMitchel">Edward Mitchel</a></span></div><div class="wp-workCard_item"><span>B15. EPIDEMIOLOGY AND PATHOGENESIS OF AIRWAY NARROWING IN CHILDHOOD</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145105"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145105"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145105; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145105]").text(description); $(".js-view-count[data-work-id=21145105]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145105; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145105']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145105, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145105]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145105,"title":"Infant Bronchiolitis Modifies The Effect Of Maternal Smoking During Pregnancy On The Risk Of Childhood Asthma","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"B15. 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Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inhibit the norepinephrine reuptake transporter (NRI). NRI medications can increase sympathetic nervous system tone, which may increase heart rate (HR) and worsen symptoms in POTS patients. We sought to determine whether NRI with atomoxetine increases standing tachycardia or worsens the symptom burden in POTS patients. Patients with POTS (n = 27) underwent an acute drug trial of atomoxetine 40 mg and placebo on separate mornings in a randomized, crossover design. Blood pressure (BP), HR, and symptoms were assessed while seated and after standing prior to and hourly for 4 hours following study drug administration. Atomoxetine significantly increased standing HR compared with placebo ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8ad95e98e53c02c7bcbb935ab29fe02c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735179,"asset_id":21145104,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41735179/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145104"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145104"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145104; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145104]").text(description); $(".js-view-count[data-work-id=21145104]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145104; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145104']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145104, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8ad95e98e53c02c7bcbb935ab29fe02c" } } $('.js-work-strip[data-work-id=21145104]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145104,"title":"Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome","translated_title":"","metadata":{"abstract":"Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. 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Atomoxetine significantly increased standing HR compared with placebo ...","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of the American Heart Association"},"translated_abstract":"Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inhibit the norepinephrine reuptake transporter (NRI). NRI medications can increase sympathetic nervous system tone, which may increase heart rate (HR) and worsen symptoms in POTS patients. We sought to determine whether NRI with atomoxetine increases standing tachycardia or worsens the symptom burden in POTS patients. 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Attempts to reduce unnecessary testing have often been difficult to implement or sustain. Use of peer management through a resource utilization committee (RUC) to favorably modify test-ordering behavior in a large academic medical center. Interrupted time-series study. Medical center with inpatient care provider order entry (CPOE) system and database of ordered tests. Predominantly housestaff physicians but all clinical staff (attending physicians, housestaff, medical students, nurses, advance practice nurses, and other clinical staff) at Vanderbilt University Hospital who used CPOE systems. The RUC analyzed the ordering habits of providers during previous years and made 2 interventions by modifying software for the CPOE system. The committee first initiated a daily prompt in the system that asked providers whether they wanted to discontinue tests scheduled beyond 72 hours. 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Aft...","publication_name":"Annals of internal medicine"},"translated_abstract":"Laboratory testing of hospitalized patients, although essential, can be expensive and sometimes excessive. Attempts to reduce unnecessary testing have often been difficult to implement or sustain. Use of peer management through a resource utilization committee (RUC) to favorably modify test-ordering behavior in a large academic medical center. Interrupted time-series study. Medical center with inpatient care provider order entry (CPOE) system and database of ordered tests. Predominantly housestaff physicians but all clinical staff (attending physicians, housestaff, medical students, nurses, advance practice nurses, and other clinical staff) at Vanderbilt University Hospital who used CPOE systems. The RUC analyzed the ordering habits of providers during previous years and made 2 interventions by modifying software for the CPOE system. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145145"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21145145/Innovative_Analyses_Support_a_Role_for_DNA_Damage_and_an_Aberrant_Cell_Cycle_in_Myelodysplastic_Syndrome_Pathogenesis"><img alt="Research paper thumbnail of Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/41735206/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21145145/Innovative_Analyses_Support_a_Role_for_DNA_Damage_and_an_Aberrant_Cell_Cycle_in_Myelodysplastic_Syndrome_Pathogenesis">Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis</a></div><div class="wp-workCard_item"><span>Bone Marrow Research</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="faf1bbaec97f52c26246266c44d045f7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735206,"asset_id":21145145,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41735206/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145145"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145145"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145145; 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ELISA was preferred because of cost and ease of performance.","publication_date":{"day":null,"month":null,"year":1988,"errors":{}},"publication_name":"Journal of Medical Virology","grobid_abstract_attachment_id":41735210},"translated_abstract":null,"internal_url":"https://www.academia.edu/21145139/Laboratory_and_epidemiologic_assessment_of_a_recent_influenza_B_outbreak","translated_internal_url":"","created_at":"2016-01-29T07:44:40.139-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141437,"work_id":21145139,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288784,"email":"e***d@ariessun.com","display_order":0,"name":"Kathryn Edwards","title":"Laboratory and epidemiologic assessment of a recent influenza B outbreak"}],"downloadable_attachments":[{"id":41735210,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41735210/thumbnails/1.jpg","file_name":"jmv.1890250313.pdf20160129-8806-1xi3p9m","download_url":"https://www.academia.edu/attachments/41735210/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Laboratory_and_epidemiologic_assessment.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41735210/jmv.1890250313-libre.pdf20160129-8806-1xi3p9m?1454082402=\u0026response-content-disposition=attachment%3B+filename%3DLaboratory_and_epidemiologic_assessment.pdf\u0026Expires=1732374145\u0026Signature=WyhPtdeqwHP~8slPi0UOCKSqXGy3sqL07QrpXKZVeI2QSspkdxoL3W1ttpUDwev4JYJANSIlR9sEBYQxGvC1jxyMvTKPqH7PDQft54HI-tEGyGrfh7WyUsaEpwMtDsQ0YelOdo-UB3f~JtRjp14hGefvF-phOMo3bajWX7W4UfyGkcpb7BKa533rLEVmASKCLz9vDvqv8d~WufWeGPlcTCU0B-pL5zEmdP6qf0vDoq9WWSYcHNMJHwLnkc5mT8sk-iVnOhKV192mlolOpf8x3nqAWXyietMKmoCj6VjsrKi2I6EBBcrC6G6e90JeA9FFIvKeKWJ~vLz4zobcUs5dTQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Laboratory_and_epidemiologic_assessment_of_a_recent_influenza_B_outbreak","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":42330984,"first_name":"William","middle_initials":null,"last_name":"Dupont","page_name":"WilliamDupont4","domain_name":"independent","created_at":"2016-01-29T07:41:55.441-08:00","display_name":"William Dupont","url":"https://independent.academia.edu/WilliamDupont4"},"attachments":[{"id":41735210,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41735210/thumbnails/1.jpg","file_name":"jmv.1890250313.pdf20160129-8806-1xi3p9m","download_url":"https://www.academia.edu/attachments/41735210/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Laboratory_and_epidemiologic_assessment.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41735210/jmv.1890250313-libre.pdf20160129-8806-1xi3p9m?1454082402=\u0026response-content-disposition=attachment%3B+filename%3DLaboratory_and_epidemiologic_assessment.pdf\u0026Expires=1732374145\u0026Signature=WyhPtdeqwHP~8slPi0UOCKSqXGy3sqL07QrpXKZVeI2QSspkdxoL3W1ttpUDwev4JYJANSIlR9sEBYQxGvC1jxyMvTKPqH7PDQft54HI-tEGyGrfh7WyUsaEpwMtDsQ0YelOdo-UB3f~JtRjp14hGefvF-phOMo3bajWX7W4UfyGkcpb7BKa533rLEVmASKCLz9vDvqv8d~WufWeGPlcTCU0B-pL5zEmdP6qf0vDoq9WWSYcHNMJHwLnkc5mT8sk-iVnOhKV192mlolOpf8x3nqAWXyietMKmoCj6VjsrKi2I6EBBcrC6G6e90JeA9FFIvKeKWJ~vLz4zobcUs5dTQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":226448,"name":"Tennessee","url":"https://www.academia.edu/Documents/in/Tennessee"},{"id":397749,"name":"Medical virology","url":"https://www.academia.edu/Documents/in/Medical_virology"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":2036633,"name":"Medical","url":"https://www.academia.edu/Documents/in/Medical"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145137"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/21145137/Evaluation_of_a_New_Highly_Purified_Pertussis_Vaccine_in_Infants_and_Children"><img alt="Research paper thumbnail of Evaluation of a New Highly Purified Pertussis Vaccine in Infants and Children" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/21145137/Evaluation_of_a_New_Highly_Purified_Pertussis_Vaccine_in_Infants_and_Children">Evaluation of a New Highly Purified Pertussis Vaccine in Infants and Children</a></div><div class="wp-workCard_item"><span>Journal of Infectious Diseases</span><span>, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purified acellular pertussis vaccine (12.5 micrograms of lymphocytosis promoting factor [LPF] and...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purified acellular pertussis vaccine (12.5 micrograms of lymphocytosis promoting factor [LPF] and 12.5 micrograms of filamentous hemagglutinin [FHA]) was compared with conventional pertussis vaccine in a randomized double-blind study involving 40 children aged 4-6 y, 40 children aged 18-24 mo, and 50 infants. Increases in antibody were significantly greater among recipients of acellular vaccine than among recipients of conventional vaccine for antibodies to LPF in all age groups and for antibodies to FHA in infants and children aged 4-6 y; the increase in FHA antibody was also greater with acellular vaccine among children aged 18-24 mo but not significantly so. Compared with conventional vaccine, acellular vaccine was significantly associated with reduced frequency of leg pain and fretfulness at all ages and less frequent fever and anorexia at some ages. The reduced reaction rates and comparable or enhanced immunogenicity of the acellular vaccine make it an attractive candidate for larger field trials, particularly among infants.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145137"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145137"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145137; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145137]").text(description); $(".js-view-count[data-work-id=21145137]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145137; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145137']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145137, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145137]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145137,"title":"Evaluation of a New Highly Purified Pertussis Vaccine in Infants and Children","translated_title":"","metadata":{"abstract":"Purified acellular pertussis vaccine (12.5 micrograms of lymphocytosis promoting factor [LPF] and 12.5 micrograms of filamentous hemagglutinin [FHA]) was compared with conventional pertussis vaccine in a randomized double-blind study involving 40 children aged 4-6 y, 40 children aged 18-24 mo, and 50 infants. Increases in antibody were significantly greater among recipients of acellular vaccine than among recipients of conventional vaccine for antibodies to LPF in all age groups and for antibodies to FHA in infants and children aged 4-6 y; the increase in FHA antibody was also greater with acellular vaccine among children aged 18-24 mo but not significantly so. Compared with conventional vaccine, acellular vaccine was significantly associated with reduced frequency of leg pain and fretfulness at all ages and less frequent fever and anorexia at some ages. The reduced reaction rates and comparable or enhanced immunogenicity of the acellular vaccine make it an attractive candidate for larger field trials, particularly among infants.","publication_date":{"day":null,"month":null,"year":1989,"errors":{}},"publication_name":"Journal of Infectious Diseases"},"translated_abstract":"Purified acellular pertussis vaccine (12.5 micrograms of lymphocytosis promoting factor [LPF] and 12.5 micrograms of filamentous hemagglutinin [FHA]) was compared with conventional pertussis vaccine in a randomized double-blind study involving 40 children aged 4-6 y, 40 children aged 18-24 mo, and 50 infants. Increases in antibody were significantly greater among recipients of acellular vaccine than among recipients of conventional vaccine for antibodies to LPF in all age groups and for antibodies to FHA in infants and children aged 4-6 y; the increase in FHA antibody was also greater with acellular vaccine among children aged 18-24 mo but not significantly so. Compared with conventional vaccine, acellular vaccine was significantly associated with reduced frequency of leg pain and fretfulness at all ages and less frequent fever and anorexia at some ages. The reduced reaction rates and comparable or enhanced immunogenicity of the acellular vaccine make it an attractive candidate for larger field trials, particularly among infants.","internal_url":"https://www.academia.edu/21145137/Evaluation_of_a_New_Highly_Purified_Pertussis_Vaccine_in_Infants_and_Children","translated_internal_url":"","created_at":"2016-01-29T07:44:39.998-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141438,"work_id":21145137,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288784,"email":"e***d@ariessun.com","display_order":0,"name":"Kathryn Edwards","title":"Evaluation of a New Highly Purified Pertussis Vaccine in Infants and Children"}],"downloadable_attachments":[],"slug":"Evaluation_of_a_New_Highly_Purified_Pertussis_Vaccine_in_Infants_and_Children","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42330984,"first_name":"William","middle_initials":null,"last_name":"Dupont","page_name":"WilliamDupont4","domain_name":"independent","created_at":"2016-01-29T07:41:55.441-08:00","display_name":"William Dupont","url":"https://independent.academia.edu/WilliamDupont4"},"attachments":[],"research_interests":[{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":210665,"name":"Infectious","url":"https://www.academia.edu/Documents/in/Infectious"},{"id":543531,"name":"Drug evaluation","url":"https://www.academia.edu/Documents/in/Drug_evaluation"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine"},{"id":965028,"name":"Cell free System","url":"https://www.academia.edu/Documents/in/Cell_free_System"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145135"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/21145135/The_high_burden_of_pneumonia_on_US_emergency_departments_during_the_2009_influenza_pandemic"><img alt="Research paper thumbnail of The high burden of pneumonia on US emergency departments during the 2009 influenza pandemic" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/21145135/The_high_burden_of_pneumonia_on_US_emergency_departments_during_the_2009_influenza_pandemic">The high burden of pneumonia on US emergency departments during the 2009 influenza pandemic</a></div><div class="wp-workCard_item"><span>Journal of Infection</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winte...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winter season provided a unique opportunity to evaluate the association between influenza and pneumonia incidence. We sought to quantify the impact of the 2009 pandemic on the incidence of emergency department (ED) visits for pneumonia in the United States (US). Using the Nationwide Emergency Department Survey, we estimated monthly counts and rates of excess all-cause pneumonia ED visits in the US attributable to the pandemic by comparing observed pneumonia ED visits during the pandemic (April 2009-March 2010) to expected values modeled from the three prior years. The pandemic was associated with an excess of 180,560 pneumonia ED visits or 0.59 excess pneumonia visits per 1000 US population (95% confidence interval: 0.55, 0.62). These excess visits accounted for 7.0% of all pneumonia ED visits during the pandemic year. The greatest excess occurred during months with highest influenza activity (September-November 2009). Persons aged &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;65 years accounted for 94% of the excess pneumonia visits. ED visits for pneumonia increased substantially during the 2009 pandemic, especially during peak influenza activity, suggesting a strong association between influenza activity and pneumonia incidence during the pandemic period.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145135"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145135"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145135; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145135]").text(description); $(".js-view-count[data-work-id=21145135]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145135; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145135']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145135, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145135]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145135,"title":"The high burden of pneumonia on US emergency departments during the 2009 influenza pandemic","translated_title":"","metadata":{"abstract":"During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winter season provided a unique opportunity to evaluate the association between influenza and pneumonia incidence. We sought to quantify the impact of the 2009 pandemic on the incidence of emergency department (ED) visits for pneumonia in the United States (US). Using the Nationwide Emergency Department Survey, we estimated monthly counts and rates of excess all-cause pneumonia ED visits in the US attributable to the pandemic by comparing observed pneumonia ED visits during the pandemic (April 2009-March 2010) to expected values modeled from the three prior years. The pandemic was associated with an excess of 180,560 pneumonia ED visits or 0.59 excess pneumonia visits per 1000 US population (95% confidence interval: 0.55, 0.62). These excess visits accounted for 7.0% of all pneumonia ED visits during the pandemic year. The greatest excess occurred during months with highest influenza activity (September-November 2009). Persons aged \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;65 years accounted for 94% of the excess pneumonia visits. ED visits for pneumonia increased substantially during the 2009 pandemic, especially during peak influenza activity, suggesting a strong association between influenza activity and pneumonia incidence during the pandemic period.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of Infection"},"translated_abstract":"During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winter season provided a unique opportunity to evaluate the association between influenza and pneumonia incidence. We sought to quantify the impact of the 2009 pandemic on the incidence of emergency department (ED) visits for pneumonia in the United States (US). Using the Nationwide Emergency Department Survey, we estimated monthly counts and rates of excess all-cause pneumonia ED visits in the US attributable to the pandemic by comparing observed pneumonia ED visits during the pandemic (April 2009-March 2010) to expected values modeled from the three prior years. The pandemic was associated with an excess of 180,560 pneumonia ED visits or 0.59 excess pneumonia visits per 1000 US population (95% confidence interval: 0.55, 0.62). These excess visits accounted for 7.0% of all pneumonia ED visits during the pandemic year. The greatest excess occurred during months with highest influenza activity (September-November 2009). Persons aged \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;65 years accounted for 94% of the excess pneumonia visits. ED visits for pneumonia increased substantially during the 2009 pandemic, especially during peak influenza activity, suggesting a strong association between influenza activity and pneumonia incidence during the pandemic period.","internal_url":"https://www.academia.edu/21145135/The_high_burden_of_pneumonia_on_US_emergency_departments_during_the_2009_influenza_pandemic","translated_internal_url":"","created_at":"2016-01-29T07:44:39.758-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141498,"work_id":21145135,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288794,"email":"z***u@math.uci.edu","display_order":0,"name":"Yuwei Zhu","title":"The high burden of pneumonia on US emergency departments during the 2009 influenza pandemic"}],"downloadable_attachments":[],"slug":"The_high_burden_of_pneumonia_on_US_emergency_departments_during_the_2009_influenza_pandemic","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42330984,"first_name":"William","middle_initials":null,"last_name":"Dupont","page_name":"WilliamDupont4","domain_name":"independent","created_at":"2016-01-29T07:41:55.441-08:00","display_name":"William Dupont","url":"https://independent.academia.edu/WilliamDupont4"},"attachments":[],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":109739,"name":"Infection","url":"https://www.academia.edu/Documents/in/Infection"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":594653,"name":"Pandemics","url":"https://www.academia.edu/Documents/in/Pandemics"},{"id":649451,"name":"Seasons","url":"https://www.academia.edu/Documents/in/Seasons"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145132"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21145132/Proteomic_analysis_of_osteogenic_sarcoma_association_of_tumour_necrosis_factor_with_poor_prognosis"><img alt="Research paper thumbnail of Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis" class="work-thumbnail" src="https://attachments.academia-assets.com/41735223/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21145132/Proteomic_analysis_of_osteogenic_sarcoma_association_of_tumour_necrosis_factor_with_poor_prognosis">Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis</a></div><div class="wp-workCard_item"><span>International Journal of Experimental Pathology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="380a3f92c86fb1d343cd0959cf4d81e4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735223,"asset_id":21145132,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41735223/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145132"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145132"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145132; 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Molecular signatures that predict pulmonary metastasis from primary osteogenic sarcoma and identify those patients at risk would be clinically useful as prognostic markers. Protein expression profiles of two clonally related murine osteogenic sarcoma cell lines with low (K12) and high (K7M2) metastatic potential were compared using two different proteomic technologies, twodimensional difference gel electrophoresis and cell profiling by matrix-assisted laser desorption ⁄ ionization mass spectrometry. Interrogation of a molecular pathways network database suggested several additional candidate molecules that potentially predict metastatic potential of primary osteogenic sarcoma. Two such proteins, macrophage migration inhibitory factor and tumour necrosis factor were selected for further validation studies. Western blots confirmed increased expression of both cytokines in K7M2 cells compared to K12 cells. Levels of migration inhibitory factor and tumour necrosis factor were semi-quantitatively measured in human osteogenic sarcoma samples by immunohistochemistry and were correlated with clinicopathologic parameters and patient outcomes. Multivariate survival analysis demonstrated that tumour necrosis factor expression in chemotherapy naïve osteogenic sarcoma is an independent prognostic factor for overall and metastasis-free survival. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20731308"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20731308/Effects_of_ibuprofen_on_the_physiology_and_survival_of_hypothermic_sepsis"><img alt="Research paper thumbnail of Effects of ibuprofen on the physiology and survival of hypothermic sepsis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20731308/Effects_of_ibuprofen_on_the_physiology_and_survival_of_hypothermic_sepsis">Effects of ibuprofen on the physiology and survival of hypothermic sepsis</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://vanderbilthealth.academia.edu/BrianChristman">Brian Christman</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/WilliamDupont4">William Dupont</a></span></div><div class="wp-workCard_item"><span>Critical Care Medicine</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The objective was to compare the clinical and physiologic characteristics of febrile septic patie...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The objective was to compare the clinical and physiologic characteristics of febrile septic patients with hypothermic septic patients; and to examine plasma levels of cytokines tumor necrosis factor alpha (TNF-alpha and interleukin 6 (IL-6) and the lipid mediators thromboxane B2 (TxB2) and prostacyclin in hypothermic septic patients in comparison with febrile patients. Most importantly, we wanted to report the effect of ibuprofen treatment on vital signs, organ failure, and mortality in hypothermic sepsis. The study was performed in the intensive care units (ICUs) of seven clinical centers in the United States and Canada. Four hundred fifty-five patients admitted to the ICU who met defined criteria for severe sepsis and were suspected of having a serious infection. Ibuprofen at a dose of 10 mg/kg (maximum 800 mg) was administered intravenously over 30 to 60 mins every 6 hrs for eight doses vs. placebo (glycine buffer vehicle). Forty-four (10%) septic patients met criteria for hypothermia and 409 were febrile. The mortality rate was significantly higher in hypothermic patients, 70% vs. 35% for febrile patients. At study entry, urinary metabolites of TxB2, prostacyclin, and serum levels of TNF-alpha and IL-6 were significantly elevated in hypothermic patients compared with febrile patients. In hypothermic patients treated with ibuprofen, there was a trend toward an increased number of days free of major organ system failures and a significant reduction in the 30-day mortality rate from 90% (18/20 placebo-treated patients) to 54% (13/24 ibuprofen-treated patients). Hypothermic sepsis has an incidence of approximately 10% and an untreated mortality twice that of severe sepsis presenting with fever. When compared with febrile patients, the hypothermic group has an amplified response with respect to cytokines TNF-alpha and IL-6 and lipid mediators TxB2 and prostacyclin. Treatment with ibuprofen may decrease mortality in this select group of septic patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20731308"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20731308"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20731308; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20731308]").text(description); $(".js-view-count[data-work-id=20731308]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20731308; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20731308']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20731308, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20731308]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20731308,"title":"Effects of ibuprofen on the physiology and survival of hypothermic sepsis","translated_title":"","metadata":{"abstract":"The objective was to compare the clinical and physiologic characteristics of febrile septic patients with hypothermic septic patients; and to examine plasma levels of cytokines tumor necrosis factor alpha (TNF-alpha and interleukin 6 (IL-6) and the lipid mediators thromboxane B2 (TxB2) and prostacyclin in hypothermic septic patients in comparison with febrile patients. Most importantly, we wanted to report the effect of ibuprofen treatment on vital signs, organ failure, and mortality in hypothermic sepsis. The study was performed in the intensive care units (ICUs) of seven clinical centers in the United States and Canada. Four hundred fifty-five patients admitted to the ICU who met defined criteria for severe sepsis and were suspected of having a serious infection. Ibuprofen at a dose of 10 mg/kg (maximum 800 mg) was administered intravenously over 30 to 60 mins every 6 hrs for eight doses vs. placebo (glycine buffer vehicle). Forty-four (10%) septic patients met criteria for hypothermia and 409 were febrile. The mortality rate was significantly higher in hypothermic patients, 70% vs. 35% for febrile patients. At study entry, urinary metabolites of TxB2, prostacyclin, and serum levels of TNF-alpha and IL-6 were significantly elevated in hypothermic patients compared with febrile patients. In hypothermic patients treated with ibuprofen, there was a trend toward an increased number of days free of major organ system failures and a significant reduction in the 30-day mortality rate from 90% (18/20 placebo-treated patients) to 54% (13/24 ibuprofen-treated patients). Hypothermic sepsis has an incidence of approximately 10% and an untreated mortality twice that of severe sepsis presenting with fever. When compared with febrile patients, the hypothermic group has an amplified response with respect to cytokines TNF-alpha and IL-6 and lipid mediators TxB2 and prostacyclin. 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Four hundred fifty-five patients admitted to the ICU who met defined criteria for severe sepsis and were suspected of having a serious infection. Ibuprofen at a dose of 10 mg/kg (maximum 800 mg) was administered intravenously over 30 to 60 mins every 6 hrs for eight doses vs. placebo (glycine buffer vehicle). Forty-four (10%) septic patients met criteria for hypothermia and 409 were febrile. The mortality rate was significantly higher in hypothermic patients, 70% vs. 35% for febrile patients. At study entry, urinary metabolites of TxB2, prostacyclin, and serum levels of TNF-alpha and IL-6 were significantly elevated in hypothermic patients compared with febrile patients. In hypothermic patients treated with ibuprofen, there was a trend toward an increased number of days free of major organ system failures and a significant reduction in the 30-day mortality rate from 90% (18/20 placebo-treated patients) to 54% (13/24 ibuprofen-treated patients). Hypothermic sepsis has an incidence of approximately 10% and an untreated mortality twice that of severe sepsis presenting with fever. When compared with febrile patients, the hypothermic group has an amplified response with respect to cytokines TNF-alpha and IL-6 and lipid mediators TxB2 and prostacyclin. Treatment with ibuprofen may decrease mortality in this select group of septic patients.","internal_url":"https://www.academia.edu/20731308/Effects_of_ibuprofen_on_the_physiology_and_survival_of_hypothermic_sepsis","translated_internal_url":"","created_at":"2016-01-24T17:36:36.539-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42026945,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":13619930,"work_id":20731308,"tagging_user_id":42026945,"tagged_user_id":null,"co_author_invite_id":1868953,"email":"s***p@u.washington.edu","display_order":0,"name":"Kenneth Steinberg","title":"Effects of ibuprofen on the physiology and survival of hypothermic sepsis"},{"id":13619936,"work_id":20731308,"tagging_user_id":42026945,"tagged_user_id":null,"co_author_invite_id":2041999,"email":"w***n@vanderbilt.edu","display_order":4194304,"name":"William Fulkerson","title":"Effects of ibuprofen on the physiology and survival of hypothermic 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20731306/Hypoproteinemia_predicts_acute_respiratory_distress_syndrome_development_weight_gain_and_death_in_patients_with_sepsis"><img alt="Research paper thumbnail of Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20731306/Hypoproteinemia_predicts_acute_respiratory_distress_syndrome_development_weight_gain_and_death_in_patients_with_sepsis">Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://vanderbilthealth.academia.edu/BrianChristman">Brian Christman</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/WilliamDupont4">William Dupont</a></span></div><div class="wp-workCard_item"><span>Critical Care Medicine</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Starling&amp;amp;amp;#39;s equation indicates that reduced oncotic pressure gradients will favor ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Starling&amp;amp;amp;#39;s equation indicates that reduced oncotic pressure gradients will favor edema formation, and the current consensus definition of acute respiratory distress syndrome (ARDS) excludes only the hydrostatic pressure contribution. We hypothesized that low serum total protein levels might correlate with the likelihood of ARDS in at-risk patients because serum total protein is the chief determinant of oncotic pressure in humans. Regression analysis to compare outcomes in patients with low serum total protein levels with outcomes in patients with normal serum total protein levels with respect to weight change, development of ARDS, and mortality. Intensive care units (ICUs) of seven clinical centers in North America. A total of 455 ICU patients who met consensus criteria for severe sepsis (178 of whom developed ARDS) from a recently completed prospective clinical trial. None. We found that 92% of the patients developing ARDS had low or borderline serum total protein levels (&amp;amp;amp;lt;6 g/dL). Logistic and multiple regression analyses confirmed that of 18 clinical variables, initial serum total protein level and protein change over time were the most statistically significant predictors of weight gain, prolonged mechanical ventilation, ARDS development, and mortality in the study population. This correlation remained significant after adjustment for the other major predictors of outcome present at baseline (ie, Acute Physiology and Chronic Health Evaluation II score). Hypoproteinemia is significantly correlated with fluid retention and weight gain, development of ARDS and poor respiratory outcome, and mortality in patients with sepsis. Prospective, randomized trials of serum protein manipulation are needed to establish whether there is a cause-effect relationship to this association.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20731306"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20731306"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20731306; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20731306]").text(description); $(".js-view-count[data-work-id=20731306]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20731306; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20731306']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20731306, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20731306]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20731306,"title":"Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis","translated_title":"","metadata":{"abstract":"Starling\u0026amp;amp;amp;#39;s equation indicates that reduced oncotic pressure gradients will favor edema formation, and the current consensus definition of acute respiratory distress syndrome (ARDS) excludes only the hydrostatic pressure contribution. We hypothesized that low serum total protein levels might correlate with the likelihood of ARDS in at-risk patients because serum total protein is the chief determinant of oncotic pressure in humans. Regression analysis to compare outcomes in patients with low serum total protein levels with outcomes in patients with normal serum total protein levels with respect to weight change, development of ARDS, and mortality. Intensive care units (ICUs) of seven clinical centers in North America. A total of 455 ICU patients who met consensus criteria for severe sepsis (178 of whom developed ARDS) from a recently completed prospective clinical trial. None. We found that 92% of the patients developing ARDS had low or borderline serum total protein levels (\u0026amp;amp;amp;lt;6 g/dL). 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Although regarded by some as a norma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hippus is a prominent, repetitive oscillation of the pupils. Although regarded by some as a normal variant of pupillary unrest, the clinical importance of hippus has not been investigated systematically in hospitalized patients. We conducted a retrospective cohort study of 117 hospitalized patients demonstrating hippus. To mitigate observer bias, 486 control patients were selected using 2 adjacent admissions by the same attending physician before and after each index case. The primary outcomes were mortality during the admission and within 30 days of discharge. Patients with bedside hippus were more likely to die within 30 days of observation (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.00005). Independent risk factors for death by 30 days were altered mental status (odds ratio [OR] 4.11; 95% confidence interval [CI], 2.05-8.25, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), hippus (OR 2.99; 95% CI, 1.46-6.11, P = .003), cirrhosis (P = .029), and renal disease (P = .054); angiotensin-system inhibitors were protective (P = .012). Patients with hippus were more likely to have altered mental status (OR 11.23; 95% CI, 6.27-20.09, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), a history of trauma (OR 3.76; 95% CI, 1.65-8.59, P = .002), cirrhosis (P = .038), renal disease (P = .051), and a history of using iron supplements (P = .016). The recognition of hippus in hospitalized patients is a clinically important predictor of early mortality.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145124"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145124"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145124; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145124]").text(description); $(".js-view-count[data-work-id=21145124]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145124; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145124']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145124, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145124]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145124,"title":"Increased Hospital Mortality in Patients with Bedside Hippus","translated_title":"","metadata":{"abstract":"Hippus is a prominent, repetitive oscillation of the pupils. Although regarded by some as a normal variant of pupillary unrest, the clinical importance of hippus has not been investigated systematically in hospitalized patients. We conducted a retrospective cohort study of 117 hospitalized patients demonstrating hippus. To mitigate observer bias, 486 control patients were selected using 2 adjacent admissions by the same attending physician before and after each index case. The primary outcomes were mortality during the admission and within 30 days of discharge. Patients with bedside hippus were more likely to die within 30 days of observation (P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.00005). Independent risk factors for death by 30 days were altered mental status (odds ratio [OR] 4.11; 95% confidence interval [CI], 2.05-8.25, P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), hippus (OR 2.99; 95% CI, 1.46-6.11, P = .003), cirrhosis (P = .029), and renal disease (P = .054); angiotensin-system inhibitors were protective (P = .012). Patients with hippus were more likely to have altered mental status (OR 11.23; 95% CI, 6.27-20.09, P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), a history of trauma (OR 3.76; 95% CI, 1.65-8.59, P = .002), cirrhosis (P = .038), renal disease (P = .051), and a history of using iron supplements (P = .016). The recognition of hippus in hospitalized patients is a clinically important predictor of early mortality.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"The American Journal of Medicine"},"translated_abstract":"Hippus is a prominent, repetitive oscillation of the pupils. Although regarded by some as a normal variant of pupillary unrest, the clinical importance of hippus has not been investigated systematically in hospitalized patients. We conducted a retrospective cohort study of 117 hospitalized patients demonstrating hippus. To mitigate observer bias, 486 control patients were selected using 2 adjacent admissions by the same attending physician before and after each index case. The primary outcomes were mortality during the admission and within 30 days of discharge. Patients with bedside hippus were more likely to die within 30 days of observation (P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.00005). Independent risk factors for death by 30 days were altered mental status (odds ratio [OR] 4.11; 95% confidence interval [CI], 2.05-8.25, P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), hippus (OR 2.99; 95% CI, 1.46-6.11, P = .003), cirrhosis (P = .029), and renal disease (P = .054); angiotensin-system inhibitors were protective (P = .012). Patients with hippus were more likely to have altered mental status (OR 11.23; 95% CI, 6.27-20.09, P \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001), a history of trauma (OR 3.76; 95% CI, 1.65-8.59, P = .002), cirrhosis (P = .038), renal disease (P = .051), and a history of using iron supplements (P = .016). The recognition of hippus in hospitalized patients is a clinically important predictor of early mortality.","internal_url":"https://www.academia.edu/21145124/Increased_Hospital_Mortality_in_Patients_with_Bedside_Hippus","translated_internal_url":"","created_at":"2016-01-29T07:44:38.552-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141426,"work_id":21145124,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288783,"email":"e***n@mcmail.vanderbilt.edu","display_order":0,"name":"Eric Neilson","title":"Increased Hospital Mortality in Patients with Bedside Hippus"}],"downloadable_attachments":[],"slug":"Increased_Hospital_Mortality_in_Patients_with_Bedside_Hippus","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42330984,"first_name":"William","middle_initials":null,"last_name":"Dupont","page_name":"WilliamDupont4","domain_name":"independent","created_at":"2016-01-29T07:41:55.441-08:00","display_name":"William Dupont","url":"https://independent.academia.edu/WilliamDupont4"},"attachments":[],"research_interests":[{"id":24377,"name":"Mortality","url":"https://www.academia.edu/Documents/in/Mortality"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":143507,"name":"Eye Movements","url":"https://www.academia.edu/Documents/in/Eye_Movements"},{"id":174781,"name":"Oscillations","url":"https://www.academia.edu/Documents/in/Oscillations"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":437772,"name":"Odds ratio","url":"https://www.academia.edu/Documents/in/Odds_ratio"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":901284,"name":"Hospital Mortality","url":"https://www.academia.edu/Documents/in/Hospital_Mortality"},{"id":1180098,"name":"Renal disease","url":"https://www.academia.edu/Documents/in/Renal_disease"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145123"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/21145123/An_Expressed_Retrogene_of_the_Master_Embryonic_Stem_Cell_Gene_POU5F1_Is_Associated_with_Prostate_Cancer_Susceptibility"><img alt="Research paper thumbnail of An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/21145123/An_Expressed_Retrogene_of_the_Master_Embryonic_Stem_Cell_Gene_POU5F1_Is_Associated_with_Prostate_Cancer_Susceptibility">An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility</a></div><div class="wp-workCard_item"><span>The American Journal of Human Genetics</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Genetic association studies of prostate and other cancers have identified a major risk locus at c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24. Several independent risk variants at this locus alter transcriptional regulatory elements, but an affected gene and mechanism for cancer predisposition have remained elusive. The retrogene POU5F1B within the locus has a preserved open reading frame encoding a homolog of the master embryonic stem cell transcription factor Oct4. We find that 8q24 risk alleles are expression quantitative trait loci correlated with reduced expression of POU5F1B in prostate tissue and that predicted deleterious POU5F1B missense variants are also associated with risk of transformation. POU5F1 is known to be self-regulated by the encoded Oct4 transcription factor. We further observe that POU5F1 expression is directly correlated with POU5F1B expression. Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145123"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145123"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145123; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145123]").text(description); $(".js-view-count[data-work-id=21145123]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145123; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145123']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145123, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145123]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145123,"title":"An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility","translated_title":"","metadata":{"abstract":"Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24. Several independent risk variants at this locus alter transcriptional regulatory elements, but an affected gene and mechanism for cancer predisposition have remained elusive. The retrogene POU5F1B within the locus has a preserved open reading frame encoding a homolog of the master embryonic stem cell transcription factor Oct4. We find that 8q24 risk alleles are expression quantitative trait loci correlated with reduced expression of POU5F1B in prostate tissue and that predicted deleterious POU5F1B missense variants are also associated with risk of transformation. POU5F1 is known to be self-regulated by the encoded Oct4 transcription factor. We further observe that POU5F1 expression is directly correlated with POU5F1B expression. Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"The American Journal of Human Genetics"},"translated_abstract":"Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24. Several independent risk variants at this locus alter transcriptional regulatory elements, but an affected gene and mechanism for cancer predisposition have remained elusive. The retrogene POU5F1B within the locus has a preserved open reading frame encoding a homolog of the master embryonic stem cell transcription factor Oct4. We find that 8q24 risk alleles are expression quantitative trait loci correlated with reduced expression of POU5F1B in prostate tissue and that predicted deleterious POU5F1B missense variants are also associated with risk of transformation. POU5F1 is known to be self-regulated by the encoded Oct4 transcription factor. We further observe that POU5F1 expression is directly correlated with POU5F1B expression. Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer.","internal_url":"https://www.academia.edu/21145123/An_Expressed_Retrogene_of_the_Master_Embryonic_Stem_Cell_Gene_POU5F1_Is_Associated_with_Prostate_Cancer_Susceptibility","translated_internal_url":"","created_at":"2016-01-29T07:44:38.282-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42330984,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":14141480,"work_id":21145123,"tagging_user_id":42330984,"tagged_user_id":null,"co_author_invite_id":3288788,"email":"j***3@sbcglobal.net","display_order":0,"name":"J. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="21145122"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/21145122/Optimizing_Personalized_Bone_Marrow_Testing_Using_an_Evidence_Based_Interdisciplinary_Team_Approach"><img alt="Research paper thumbnail of Optimizing Personalized Bone Marrow Testing Using an Evidence-Based, Interdisciplinary Team Approach" class="work-thumbnail" src="https://attachments.academia-assets.com/41735199/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/21145122/Optimizing_Personalized_Bone_Marrow_Testing_Using_an_Evidence_Based_Interdisciplinary_Team_Approach">Optimizing Personalized Bone Marrow Testing Using an Evidence-Based, Interdisciplinary Team Approach</a></div><div class="wp-workCard_item"><span>American Journal of Clinical Pathology</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="39a271093fb68eb824ba0c5903499567" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735199,"asset_id":21145122,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41735199/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145122"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145122"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145122; 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href="https://independent.academia.edu/EdwardMitchel">Edward Mitchel</a></span></div><div class="wp-workCard_item"><span>B15. EPIDEMIOLOGY AND PATHOGENESIS OF AIRWAY NARROWING IN CHILDHOOD</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145105"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145105"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145105; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145105]").text(description); $(".js-view-count[data-work-id=21145105]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145105; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145105']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145105, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=21145105]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145105,"title":"Infant Bronchiolitis Modifies The Effect Of Maternal Smoking During Pregnancy On The Risk Of Childhood Asthma","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"B15. 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Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inhibit the norepinephrine reuptake transporter (NRI). NRI medications can increase sympathetic nervous system tone, which may increase heart rate (HR) and worsen symptoms in POTS patients. We sought to determine whether NRI with atomoxetine increases standing tachycardia or worsens the symptom burden in POTS patients. Patients with POTS (n = 27) underwent an acute drug trial of atomoxetine 40 mg and placebo on separate mornings in a randomized, crossover design. Blood pressure (BP), HR, and symptoms were assessed while seated and after standing prior to and hourly for 4 hours following study drug administration. Atomoxetine significantly increased standing HR compared with placebo ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8ad95e98e53c02c7bcbb935ab29fe02c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41735179,"asset_id":21145104,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41735179/download_file?st=MTczMjM3NjE0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="21145104"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="21145104"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21145104; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21145104]").text(description); $(".js-view-count[data-work-id=21145104]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21145104; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='21145104']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 21145104, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8ad95e98e53c02c7bcbb935ab29fe02c" } } $('.js-work-strip[data-work-id=21145104]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":21145104,"title":"Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome","translated_title":"","metadata":{"abstract":"Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. 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