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id="main" class="site-main" role="main"> <article id="post-2996" class="post-2996 page type-page status-publish hentry"> <div id="breadcrumb"> <div id="crumbs"><span class="crumb"><a href="https://www.compbio.com">Home</a></span> <i class="fa fa-angle-right"></i> <span class="crumb"><a href="https://www.compbio.com/therapeutic-areas/">Therapeutic Areas</a></span> <i class="fa fa-angle-right"></i> <span class="crumb"><a href="https://www.compbio.com/dermatology/">Dermatology Overview</a></span> <i class="fa fa-angle-right"></i> <span class="current">Wound Healing Models</span></div> </div> <div class="right-top-cta"> <a href="https://www.compbio.com/contact-us/" class="button-green cta">Ask Our Experts</a> </div> <div class="entry-content"> <div class="the-content-contain"> <div class="row builder-row content-row"> <div class="medium-12 columns"> <p> <img class=" wp-image-3118 alignleft" src="https://www.compbio.com/images/wrapped-hand.png?v=1712267946" alt="" width="371" height="273" srcset="https://www.compbio.com/images/wrapped-hand.png?v=1712267946 487w, https://www.compbio.com/images/wrapped-hand-300x221.png?v=1712267964 300w" sizes="(max-width: 371px) 100vw, 371px" /> </p> <p> <img loading="lazy" class="wp-image-5255 alignleft" src="https://www.compbio.com/images/Imavita_SkinWound.png?v=1712267971" alt="" width="471" height="323" srcset="https://www.compbio.com/images/Imavita_SkinWound.png?v=1712267971 759w, https://www.compbio.com/images/Imavita_SkinWound-300x206.png?v=1712267982 300w" sizes="(max-width: 471px) 100vw, 471px" /> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p>Whether it is a small nick or large surgical incision, or a burn, healing is dependent upon the body’s ability to heal itself. A vital role is played by our own natural biomolecules in the healing process, including their contribution to the growth of new cells and the development of new blood vessels that provide nutrients to those cells. Here at Comparative Biosciences, Inc. we are developing the models to test the therapeutics that could accelerate the wound healing process.</p> <p>Wound healing studies may be conducted in normal or diabetic (streptozotocin-induced) models. Uniform wounds of full thickness, split thickness or single cuts are created surgically and healing is assessed. The test article is administered and effects of test article on size, rate and character of healing are determined.</p> <h2>CBI offers:</h2> <ul> <li>Surgical wound models</li> <li><strong><a href="https://www.compbio.com/dermal-burn-modeling/">Dermal burn models</a></strong> <ul> <li>Full and partial thickness burn-<strong> <a href="https://www.compbio.com/files/Burn-Modeling-in-Minipigs-and-Rats.pptx?v=1712252064">check out our presentation!</a></strong></li> <li>UV light induced</li> </ul> </li> <li>Chemically and immunologically induced</li> <li>Full, split thickness and minced tissue grafts</li> <li>Abraded, incisional and excisional</li> <li>Hypertrophic scarring models- <strong><a href="https://www.compbio.com/files/Rabbit-Hypertrophic-Ear-Scar-2016.pdf?v=1712269006">check out our presentation!</a></strong></li> <li>Ischemic skin</li> <li>Rabbit keloid</li> <li>Bleomycin and monocrotaline-induced</li> <li>Diabetic ulcers</li> <li>Pressure wounds</li> <li>Corneal laceration and healing</li> </ul> <h3></h3> <h3>Endpoints for wound healing studies may include:</h3> <ul> <li>Clinical signs</li> <li>DRAIZE scoring</li> <li>OCT</li> <li>Laser Doppler</li> <li>Histopathology, by <strong><a href="https://www.compbio.com/histopathology/">our in-house histopathology lab</a></strong></li> <li><strong><a href="https://www.compbio.com/immunohistochemistry/">Immunohistochemistry</a></strong></li> <li><strong><a href="https://www.compbio.com/histomorphometry-and-digital-slide-analysis/">Histomorphometry/digital image analysis</a></strong></li> <li>Tensile strength</li> <li>Transepidermal water loss</li> <li>Digital image analysis of wound size and closure</li> <li>Body temperature</li> <li>Body weights</li> <li>Hematology and clinical chemistry</li> <li>Serum and tissue markers of inflammation</li> <li>Serial biopsies</li> </ul> <p> </p> <p> </p> <p> </p> <figure id="attachment_3001" aria-describedby="caption-attachment-3001" style="width: 150px" class="wp-caption alignleft"> <a href="https://www.compbio.com/images/Picture1.jpg?v=1712268150"><img loading="lazy" class="wp-image-3001 size-thumbnail" src="https://www.compbio.com/images/Picture1-150x150.jpg?v=1712268163" width="150" height="150" /></a> <figcaption id="caption-attachment-3001" class="wp-caption-text">Full thickness burn, 3 days, with complete loss of epithelium. The underlying dermis is exposed with inflammation, edema, hemorrhage and congestion. 40x HE</figcaption> </figure> <figure id="attachment_2999" aria-describedby="caption-attachment-2999" style="width: 300px" class="wp-caption alignleft"> <a href="https://www.compbio.com/images/histo-scores-burn-inflammation-e1490650406727.png?v=1712268176"><img loading="lazy" class="wp-image-2999 size-medium" src="https://www.compbio.com/images/histo-scores-burn-inflammation-300x192.png?v=1712268184" width="300" height="192" /></a> <figcaption id="caption-attachment-2999" class="wp-caption-text">Mean Histological Scores following partial thickness burns in 4 minipigs treated with vehicle, positive control and two test articles. The test articles, vehicle and positive control all positively effected the burn resolution.</figcaption> </figure> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> </div> </div> </div> <div class="bottom-cta center"> <a href="https://www.compbio.com/contact-us/" class="button-green cta">Contact CBI</a> </div> </div> </article> </main> </div> </div> <div class="call-out"> <h3 class="content-left"><span class="line-one">Have a question</span> <span class="line-two">or need a quote?</span></h3> <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 100 85" style="enable-background:new 0 0 100 85;" xml:space="preserve"> <style type="text/css"> .st0{fill:#FFFFFF;} </style> <g> <path class="st0" d="M64.3,0.5H16c-8.8,0-16,7.2-16,16V44c0,8.4,6.6,15.4,14.9,16l-3.7,17.4L31.6,60h8.8V43.9 c0-8.7,7.1-15.8,15.8-15.8h24.2V16.5C80.3,7.7,73.1,0.5,64.3,0.5z"/> <path class="st0" d="M89.1,33h-33c-6,0-10.9,4.9-10.9,10.9v18.8c0,6,4.9,10.9,10.9,10.9h22.4l13.9,11.8l-2.5-11.9 c5.7-0.4,10.2-5.1,10.2-10.9V44C100,38,95.1,33,89.1,33z M85.5,49.3c2.2,0,4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1s-4-1.8-4-4.1 C81.5,51.1,83.3,49.3,85.5,49.3z M59.6,57.4c-2.2,0-4-1.8-4-4.1c0-2.2,1.8-4.1,4-4.1c2.2,0,4,1.8,4,4.1 C63.7,55.6,61.9,57.4,59.6,57.4z M68.5,53.4c0-2.2,1.8-4.1,4-4.1s4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1S68.5,55.6,68.5,53.4z"/> </g> </svg> <h3 class="content-right"><span>We can help!</span> <a href="https://www.compbio.com/contact-us/"><span class="cta-btn">Contact us</span></a></h3> </div> </div> </div> <footer id="colophon" class="site-footer row"> <div class="site-info medium-12 columns"> Comparative Biosciences, Inc. · <strong>Phone: 888-994-4879</strong><br> Copyright 2024 Comparative Biosciences, Inc. 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