Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar

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value="56de9b0d-ffc2-409f-8e05-ea5d1e7db4de" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div id="RootHolder_userInfoContainer" class="user-info-container"> <div class="search-centered cl"> <div class="user-info-rca-words-container"> <span> <i>RCA</i> is committed to providing an open science platform for medical science and life science researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide to discover high-quality articles, journals, and scholars through citation index evaluation. </span> </div> <div class="user-info-center-container"> <div class="left-part"> <table> <tr> <td> <a href="https://www.faculty.uci.edu/profile/?facultyId=5952" id="RootHolder_PhotoLink" target="_blank"> <img src="https://f6publishinggeneral.blob.core.windows.net/userphotos/99a253ead511418690b30ea0959da470.jpg" id="RootHolder_UserPhoto" class="user-photo" /> </a> </td> </tr> <tr id="RootHolder_SocialContainer"> <td style="text-align: center;"> <ul class="ul social-container"> <li> <a href="https://www.wjgnet.com/bpg/GerInfo/304" target="_blank"> <img src="/Contents/Images/RCAC-Logo.png" /> </a> </li> <li> <a href="https://www.webofscience.com/wos/author/record/224731" target="_blank"> <img src="/Contents/Images/publons-round.png" /> </a> </li> </ul> </td> </tr> <tr id="RootHolder_DbIndexingContainer"> <td> <ul class="ul dbindexing-container"> <li> <a href="https://www.ncbi.nlm.nih.gov/sites/myncbi/1lotw2j42xNkx/bibliography/44841196/public/?sort=date&direction=ascending" target="_blank"> <img src="/Contents/Images/PubMed.png" /> </a> </li> <li> <a href="https://www.scopus.com/authid/detail.uri?authorId=57208272030" target="_blank"> <img src="/Contents/Images/scopus-logo.png" /> </a> </li> </ul> </td> </tr> </table> </div> <div class="right-part"> <table class="user-name-container"> <tr> <td class="user-name-td"> <table style="width: 100%;"> <tr> <td> <span id="RootHolder_UserName" class="user-name-text">Shengwen Calvin Li,</span> <span id="RootHolder_AcademicTitles">BSc, MPhil, PhD, Adjunct Professor, Editor-in-Chief, Professor, Research Scientist, Senior Scientist</span> </td> </tr> </table> </td> </tr> <tr> <td> <b>RCA ID:</b> <span id="RootHolder_RCAIDText">00002131</span> </td> </tr> <tr> <td> <a href="https://referencecitationanalysis.com/00002131" id="RootHolder_rcaIdFullLink" class="rca-full">https://referencecitationanalysis.com/00002131</a> </td> </tr> </table> <table id="RootHolder_UserDetailInfoContainer" class="user-name-container"> <tr id="RootHolder_BpgJournalNameContianer"> <td> <b>Name of Journal:</b> <span class="dxeBase_MetropolisBlue" id="RootHolder_BpgJournalName">World Journal of Stem Cells</span> </td> </tr> <tr id="RootHolder_BpgPositionContainer"> <td> <b>Position:</b> <span class="dxeBase_MetropolisBlue" id="RootHolder_BpgPosition">Editor-in-Chief</span> </td> </tr> <tr id="RootHolder_BpgUserStatusContainer"> <td> <b>Status:</b> <span class="dxeBase_MetropolisBlue" id="RootHolder_BpgUserStatusName">Accepted</span> </td> </tr> <tr id="RootHolder_BpgUserAcceptTimeContainer"> <td> <b>Accepted:</b> <span class="dxeBase_MetropolisBlue" id="RootHolder_AcceptTime">August 16, 2023</span> </td> </tr> <tr> <td> <b>Research Domain:</b> <span class="dxeBase_MetropolisBlue" id="RootHolder_ResearchDomain">Cell Biology</span> </td> </tr> <tr id="RootHolder_ReviewCountContainer"> <td> <b>Peer-Review Count:</b> <span class="dxeBase_MetropolisBlue" id="RootHolder_BpgUserReviewCount">24</span> </td> </tr> <tr> <td> <div id="RootHolder_KeywordsShortContainer" class="biography-container"><b>Research Keywords:</b> Brain cancer stem cells; Cancer stem cell; Caveolae Caveolin; Glioblastoma; Immunotherapy; Mesenchymal stem cells; Neural Stem Cells; Neural stem cells transplantation; Neuroblastoma; Organoid; Organotypic slice culture; Signalling pathways</div> </td> </tr> <tr id="RootHolder_BiographyContainer"> <td> <div id="RootHolder_BiographyShortContainer" class="biography-container"><b>Biography:</b> Shengwen Calvin Li, PhD, MPhil, FRSB, FRSM. FRSB: Elected fellow, The Royal Society of Biology (2020-). FRSM: Elected Fellow, The Royal Society of Medicine (2018-). PhD: Mount Sinai School of ...<a href="javascript:void(0);" class="readmore"> [+]</a></div> <div id="RootHolder_BiographyFullContainer" class="biography-container" style="display: none;"><b>Biography:</b> Shengwen Calvin Li, PhD, MPhil, FRSB, FRSM. FRSB: Elected fellow, The Royal Society of Biology (2020-). FRSM: Elected Fellow, The Royal Society of Medicine (2018-). PhD: Mount Sinai School of Medicine, New York, NY Postdoctoral Fellowship: Whitehead Institute/Massachusetts Institute of Technology (MIT) Research Fellowship: Harvard Medical School PI and Head, Neuro-Oncology and Stem Cell Research Laboratory, Children's Hospital of Orange County (CHOC) Children’s Hospital, University of California-Irvine School of Medicine. Adjunct Professor, Thomas Jefferson University, California State University Fullerton, CA. Sun Yat-sen University. More than 148 publications, including peer-reviewed research articles, reviews, book chapters, and patent applications. His publications have been remarked in articles published in Nature, Science, Cell, and Annual Reviews of Cell and Developmental Biology (with 11342 citations, h-index 41, i10-index 81). His publication was on the top 50 most frequently cited Journal of Biological Chemistry (JBC) Articles (#49) in 2004; on top 40 in 2005 and 2006, respectively. His recent research was highlighted on the cover of the August 2, 2011 issue of Proceedings of the National Academy of Sciences of United States. He has served on the editorial board of PLOS ONE (Academic Editor), American Journal of Pathology (Official Journal of ASIP, Elsevier) since 2008, on the editorial board (section editor) of the Journal of Stem Cell & Therapy since 2011, on the editorial board of the World Journal of Stem Cells since 2012 (Editor-in-Chief, 2019-), Quantitative Imaging in Medicine and Surgery (Hong Kong), and the editorial board (Associate Editor) of Frontiers in Oncology (Switzerland) since 2021. Also, he has served as an ad-hoc reviewer for many other journals and grant agencies. Membership: Association for Clinical and Translational Science, Society for Translational and Clinical Sciences, International Society of Stem Cell Research, Society for Neuroscience, American Society for Cell Biology, American Association for the Advancement of Science, and American Society of Investigative Pathology. <a href="javascript:void(0);" class="readless">[-]</a></div> </td> </tr> <tr> <td> <b>Total View:</b> <span class="dxeBase_MetropolisBlue" id="RootHolder_UserTotalViews">1151 (1/60)</span> </td> </tr> <tr> <td> <b>Total Articles:</b> <a href="/00002131" id="RootHolder_UserTotalArticles">65 (5/60)</a> </td> </tr> <tr> <td> <b>Total Citations in RCA:</b> <a href="/citearticles?page=1&term=%5b%7b%22c%22%3a%22and%22%2c%22id%22%3a%22cr%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%2200002131%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="RootHolder_TotalCitationsInF6Link" target="_blank">3725 (3/60)</a> </td> </tr> <tr> <td> <b id="RootHolder_InfluenceIndexTitle1">Article Influence Index:</b> <a href="javascript:userIndexComputePopup.Show();" id="showUserIndexCompute" target="_self"> <svg style="width: 10px; transition: transform .1s ease-in-out; transform: rotate(270deg)" class="svg-inline--fa fa-chevron-down fa-w-14" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="chevron-down" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" data-fa-i2svg=""> <path fill="currentColor" d="M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z"></path> </svg> </a> <span class="dxeBase_MetropolisBlue" id="RootHolder_UserInfluenceIndex">85.492 (mean) (1/60)</span> </td> </tr> <tr id="RootHolder_UserWebSiteContainer"> <td style="word-break: break-word;"> <b>Institution URL:</b> <a href="https://www.faculty.uci.edu/profile/?facultyId=5952" id="RootHolder_UserWebSite" target="_blank">https://www.faculty.uci.edu/profile/?facultyId=5952</a> </td> </tr> <tr> <td> <b>Institution:</b> <span class="dxeBase_MetropolisBlue" id="RootHolder_Institution"><b>Shengwen Calvin Li, BSc, MPhil, PhD, Adjunct Professor, Editor-in-Chief, Professor, Research Scientist, Senior Scientist, </b>Center for Neuroscience and Stem Cell Research, Children's Hospital of Orange County Children's Research Institute, Children's Hospital of Orange County, Neuroscience Institute, University of California Irvine, Orange, CA 92868, United States</span> </td> </tr> </table> </div> <div class="cl"></div> </div> <div class="user-academic-center-container"> <div class="mnavbar"> <table> <tr> <td class="expandUserAcademic" style="cursor: pointer" onclick="ShowUserContainerList('expandUserAcademic', 'user-academic-list-container');"> <i class="fa fa-plus"></i> </td> <td style="cursor: pointer" 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style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Chai C</b>, Sui K, Tang J, Yu H, Yang C, Zhang H, Li SC, Zhong JF, Wang Z, Zhang X. BCR-ABL1-driven exosome-miR130b-3p-mediated gap-junction Cx43 MSC intercellular communications imply therapies of leukemic subclonal evolution. <em class='incite-journal-name' onclick='ShowInCiteJournal(22631);'>Theranostics</em> 2023;<b>13</b>:3943-3963. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37554265' target='_blank'>37554265</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405834' target='_blank'>PMC10405834</a> DOI: <a href='https://dx.doi.org/10.7150/thno.83178' target='_blank'>10.7150/thno.83178</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.7150%2fthno.83178%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.7150%2fthno.83178')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7150/thno.83178','37554265', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.7150/thno.83178' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.7150/thno.83178');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22631);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/03/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.7150/thno.83178" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Rationale: In the bone marrow microenvironment (BMME), mesenchymal stem/stromal cells (MSCs) control the self-renewal of both healthy and cancerous hematopoietic stem/progenitor cells (HSPCs). We previously showed that in vivo leukemia-derived MSCs change neighbor MSCs into leukemia-permissive states and boost leukemia cell proliferation, survival, and chemotherapy resistance. But the mechanisms behind how the state changes are still not fully understood. Methods: Here, we took a reverse engineering approach to determine BCR-ABL1+ leukemia cells activated transcriptional factor C/EBPβ, resulting in miR130a/b-3p production. Then, we back-tracked from clinical specimen transcriptome sequencing to cell co-culture, molecular and cellular assays, flow cytometry, single-cell transcriptome, and transcriptional regulation to determine the molecular mechanisms of BCR-ABL1-driven exosome-miR130b-3p-mediated gap-junction Cx43 MSC intercellular communications. Results: BCR-ABL1-driven exosome-miR130a/b-3p mediated gap-junction Cx43 (a.k.a., GJA1) BMSC intercellular communications for subclonal evolution in leukemic microenvironment by targeting BMSCs-expressed HLAs, thereby potentially maintaining BMSCs with self-renewal properties and reduced BMSC immunogenicity. The Cx43low and miR-130a/bhigh subclonal MSCs subsets of differentiation state could be reversed to Cx43high and miR-130a/blow subclones of the higher stemness state in Cx43-overexpressed subclonal MSCs. Both miR-130a and miR-130b might only inhibit Cx43 translation or degrade Cx43 proteins and did not affect Cx43 mRNA stability. The subclonal evolution was further confirmed by single-cell transcriptome profiling of MSCs, which suggested that Cx43 regulated their stemness and played normal roles in immunomodulation antigen processing. Thus, upregulated miR-130a/b promoted osteogenesis and adipogenesis from BMSCs, thereby decreasing cancer progression. Our clinical data validated that the expression of many genes in human major histocompatibility was negatively associated with the stemness of MSCs, and several immune checkpoint proteins contributing to immune escape in tumors were overexpressed after either miR-130a or miR-130b overexpression, such as CD274, LAG3, PDCD1, and TNFRSF4. Not only did immune response-related cytokine-cytokine receptor interactions and PI3K-AKT pathways, including EGR3, TNFRSF1B, but also NDRG2 leukemic-associated inflammatory factors, such as IFNB1, CXCL1, CXCL10, and CCL7 manifest upon miR-130a/b overexpression. Either BCR siRNAs or ABL1 siRNAs assay showed significantly decreased miR-130a and miR-130b expression, and chromatin immunoprecipitation sequencing confirmed that the regulation of miR-130a and miR-130b expression is BCR-ABL1-dependent. BCR-ABL1 induces miR-130a/b expression through the upregulation of transcriptional factor C/EBPβ. C/EBPβ could bind directly to the promoter region of miR-130b-3p, not miR-130a-3p. BCR-ABL1-driven exosome-miR130a-3p could interact with Cx43, and further impact GJIC in TME. Conclusion: Our findings shed light on how leukemia BCR-ABL1-driven exosome-miR130b-3p could interact with gap-junction Cx43, and further impact GJIC in TME, implications for leukemic therapies of subclonal evolution. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B+progenitor+acute+lymphoblastic+leukemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B progenitor acute lymphoblastic leukemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BCR-ABL1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BCR-ABL1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cx43%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cx43</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MSCs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MSCs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22acute+lymphoblastic+leukemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">acute lymphoblastic leukemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemotherapy+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemotherapy resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gap+junctions%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gap junctions</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22leukemic+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">leukemic microenvironment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miR-130a+and+miR-130b%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miR-130a and miR-130b</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22stemness%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">stemness</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Communication%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Communication/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Connexin+43%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Connexin 43/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukemia%2c+Myelogenous%2c+Chronic%2c+BCR-ABL+Positive%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphatidylinositol+3-Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphatidylinositol 3-Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Proteins/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Zhang J</b>, Su Q, Li SC. Qigong Exercise Balances Oxygen Supply and Acid-Base to Modulate Hypoxia: A Perspective Platform toward Preemptive Health & Medicine. <em class='incite-journal-name' onclick='ShowInCiteJournal(168176);'>Med Sci (Basel)</em> 2023;<b>11</b>:medsci11010021. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36976529' target='_blank'>36976529</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057714' target='_blank'>PMC10057714</a> DOI: <a href='https://dx.doi.org/10.3390/medsci11010021' target='_blank'>10.3390/medsci11010021</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/medsci11010021','36976529', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/medsci11010021' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168176);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/21/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/04/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.3390/medsci11010021" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <jats:p>Qigong is a meditative movement with therapeutic effects and is commonly practiced in Eastern medicine. A growing body of evidence validates its health benefits, leading to mechanistic questions about how it works. We propose a novel mechanism by which the “acid” caused by hypoxia affects metabolism, and the way it is neutralized through Qigong practice involves the body’s blood flow and vasculature modifications. Specifically, Qigong exercise generates an oxygen supply and acid-base balance against the hypoxic effects of underlying pathological conditions. We also propose that Qigong exercise mediated and focused on the local hypoxia environment of tissues might normalize the circulation of metabolic and inflammation accumulation in the tumor tissue and restore the normal metabolism of tissues and cells through calm, relaxation, and extreme Zen-style breathing that gravitates toward preemptive health and medicine. Thus, we propose the mechanisms of action related to Qigong, intending to unify Eastern and Western exercise theory.</jats:p> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qigong%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qigong</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exercise+Therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exercise Therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exercise%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exercise</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Meditation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Meditation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxygen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxygen</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Wang J</b>, Li X, Zhou J, Qiu D, Zhang M, Sun L, Li SC. Long-term survival with anlotinib as a front-line treatment in an elderly NSCLC patient: A case report. <em class='incite-journal-name' onclick='ShowInCiteJournal(9356);'>Front Oncol</em> 2023;<b>13</b>:1043244. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37091182' target='_blank'>37091182</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117841' target='_blank'>PMC10117841</a> DOI: <a href='https://dx.doi.org/10.3389/fonc.2023.1043244' target='_blank'>10.3389/fonc.2023.1043244</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3389%2ffonc.2023.1043244%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3389%2ffonc.2023.1043244')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fonc.2023.1043244','37091182', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fonc.2023.1043244' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fonc.2023.1043244');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9356);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/13/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.3389/fonc.2023.1043244" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Half of the population of non-small cell lung cancer (NSCLC) patients are older than 70 years and have limited therapeutic options due to poor tolerance and being excluded in most clinical trials. Anlotinib hydrochloride, a novel oral multi-target tyrosine kinase inhibitor, has been approved for the standard third-line treatment for NSCLC in China. Herein we report an elderly NSCLC patient without any driver gene mutations who was undergoing anlotinib as a front-line treatment and who achieved long-term survival.</div><div class="abstract-label">Case summary</div><div class="abstract-content">The 77-year-old male patient was admitted to the hospital for chest tightness after engaging in physical activity for a week. The patient has been diagnosed with stage IIIB driver gene-negative squamous cell lung carcinoma. After that, he was treated with anlotinib for 2 years and 10 months from the first diagnosis until the last disease progression. Briefly, anlotinib combined with platinum-based chemotherapy was performed as the first-line therapy over six cycles. After 6 more cycles of anlotinib monotherapy maintenance, disease progression occurred. Then, anlotinib combined with tegafur was administered as a salvage treatment, and the disease was controlled again. After 29 cycles of anlotinib combined with tegafur regimens, the disease progressed finally. The patient achieved a total of 34 months of progression-free survival after anlotinib was used as the front-line treatment. He is still alive with a good performance status now (performance status score: 1).</div><div class="abstract-label">Conclusion</div><div class="abstract-content">This patient achieved long-term survival using anlotinib as a front-line regimen combined with chemotherapy.</div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anlotinib+hydrochloride%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anlotinib hydrochloride</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anti-angiogenesis+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anti-angiogenesis therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22case+report%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">case report</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22elderly+patients%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">elderly patients</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22front-line+treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">front-line treatment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22non-small+cell+lung+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">non-small cell lung cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tegafur-uracil%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tegafur-uracil</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Sun L</b>, Li X, Tu L, Stucky A, Huang C, Chen X, Cai J, Li SC. RNA-Sequencing Combined With Genome-Wide Allele-Specific Expression Patterning Identifies ZNF44 Variants as a Potential New Driver Gene for Pediatric Neuroblastoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(4453);'>Cancer Control</em> 2023;<b>30</b>:10732748231175017. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37161925' target='_blank'>37161925</a> DOI: <a href='https://dx.doi.org/10.1177/10732748231175017' target='_blank'>10.1177/10732748231175017</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/10732748231175017','37161925', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1177/10732748231175017' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4453);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/11/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1177/10732748231175017" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Neuroblastoma (NB) is one of the children's most common solid tumors, accounting for approximately 8% of pediatric malignancies and 15% of childhood cancer deaths. Somatic mutations in several genes, such as <i>ALK</i>, have been associated with NB progression and can facilitate the discovery of novel therapeutic strategies. However, the differential expression of mutated and wild-type alleles on the transcriptome level is poorly studied.</div><div class="abstract-label">METHODS</div><div class="abstract-content">This study analyzed 219 whole-exome sequencing datasets with somatic mutations detected by MuTect from paired normal and tumor samples.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">We prioritized mutations in 8 candidate genes (<i>RIMS4</i>, <i>RUSC2</i>, <i>ALK</i>, <i>MYCN</i>, <i>PTPN11</i>, <i>ALOX12B</i>, <i>ZNF44</i>, and <i>CNGB1</i>) as potential driver mutations. We further confirmed the presence of allele-specific expression of the somatic mutations in NB with integrated analysis of 127 RNA-seq samples (of which 85 also had DNA-seq data available), including <i>MYCN</i>, <i>ALK</i>, and <i>PTPN11</i>. The allele-specific expression of mutations suggests that the same somatic mutation may have different effects on the clinical outcomes of tumors.</div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our study suggests 2 novel variants of <i>ZNF44</i> as a novel candidate driver gene for NB.</div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-seq%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-seq</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ZNF44%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZNF44</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22allele-specific+expression+pattern%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">allele-specific expression pattern</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuroblastoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuroblastoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22somatic+mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">somatic mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22whole-exome+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">whole-exome sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Li SC</b>, Kabeer MH. Caveolae-Mediated Extracellular Vesicle (CMEV) Signaling of Polyvalent Polysaccharide Vaccination: A Host-Pathogen Interface Hypothesis. <em class='incite-journal-name' onclick='ShowInCiteJournal(18983);'>Pharmaceutics</em> 2022;<b>14</b>:pharmaceutics14122653. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36559147' target='_blank'>36559147</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784826' target='_blank'>PMC9784826</a> DOI: <a href='https://dx.doi.org/10.3390/pharmaceutics14122653' target='_blank'>10.3390/pharmaceutics14122653</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/pharmaceutics14122653','36559147', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/pharmaceutics14122653' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/pharmaceutics14122653');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18983);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/28/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/22/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/22/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/02/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.3390/pharmaceutics14122653" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">We published a study showing that improvement in response to splenectomy associated defective, in regards to the antibody response to Pneumovax<sup>®</sup> 23 (23-valent polysaccharides, PPSV23), can be achieved by splenocyte reinfusion. This study triggered a debate on whether and how primary and secondary immune responses occur based on humoral antibody responses to the initial vaccination and revaccination. The anti-SARS-CoV-2 vaccine sheds new light on the interpretation of our previous data. Here, we offer an opinion on the administration of the polyvalent polysaccharide vaccine (PPSV23), which appears to be highly relevant to the primary vaccine against SARS-CoV-2 and its booster dose. Thus, we do not insist this is a secondary immune response but an antibody response, nonetheless, as measured through IgG titers after revaccination. However, we contend that we are not sure if these lower but present IgG levels against pneumococcal antigens are clinically protective or are equally common in all groups because of the phenomenon of "hyporesponsiveness" seen after repeated polysaccharide vaccine challenge. We review the literature and propose a new mechanism-caveolae memory extracellular vesicles (CMEVs)-by which polysaccharides mediate prolonged and sustained immune response post-vaccination. We further delineate and explain the data sets to suggest that the dual targets on both Cav-1 and SARS-CoV-2 spike proteins may block the viral entrance and neutralize viral load, which minimizes the immune reaction against viral attacks and inflammatory responses. Thus, while presenting our immunological opinion, we answer queries and responses made by readers to our original statements published in our previous work and propose a hypothesis for all vaccination strategies, i.e., caveolae-mediated extracellular vesicle-mediated vaccine memory.</div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polyvalent+polysaccharide+vaccine+(PPSV)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polyvalent polysaccharide vaccine (PPSV)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caveolae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">caveolae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caveolae+memory+extracellular+vesicles+(CMEVs)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">caveolae memory extracellular vesicles (CMEVs)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polysaccharides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vaccine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vaccine</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Li X</b>, Wang X, Huang R, Stucky A, Chen X, Sun L, Wen Q, Zeng Y, Fletcher H, Wang C, Xu Y, Cao H, Sun F, Li SC, Zhang X, Zhong JF. The Machine-Learning-Mediated Interface of Microbiome and Genetic Risk Stratification in Neuroblastoma Reveals Molecular Pathways Related to Patient Survival. <em class='incite-journal-name' onclick='ShowInCiteJournal(4622);'>Cancers (Basel)</em> 2022;<b>14</b>:cancers14122874. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35740540' target='_blank'>35740540</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220810' target='_blank'>PMC9220810</a> DOI: <a href='https://dx.doi.org/10.3390/cancers14122874' target='_blank'>10.3390/cancers14122874</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fcancers14122874%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 4</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fcancers14122874')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/cancers14122874','35740540', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(6);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/cancers14122874' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/276e3db71d67c0e88204aebdb879dad3/PMC9220810.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/cancers14122874');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4622);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/15/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/23/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/30/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/01/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.3390/cancers14122874" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Simple Summary</div><p>Neuroblastoma is a highly heterogeneous malignancy with a wide range of outcomes from spontaneous regression to fatal chemoresistant disease, as currently treated according to the risk stratification of the Children’s Oncology Group (COG), resulting in some high COG risk patients receiving excessive treatment, due to lacking predictors for treatment response. Here, we sought to complement COG risk classification by using the tumor intracellular microbiome, which is part of the tumor’s molecular signature. We determine that an intra-tumor microbial gene abundance score, namely M-score, separates the high COG-risk patients into two subpopulations (M<sub>high</sub> and M<sub>low</sub>) with higher accuracy in risk stratification than the current COG risk assessment, thus sparing a subset of high COG-risk patients from being subjected to traditional high-risk therapies.</p><div class="abstract-label">Abstract</div><p>Currently, most neuroblastoma patients are treated according to the Children’s Oncology Group (COG) risk group assignment; however, neuroblastoma’s heterogeneity renders only a few predictors for treatment response, resulting in excessive treatment. Here, we sought to couple COG risk classification with tumor intracellular microbiome, which is part of the molecular signature of a tumor. We determine that an intra-tumor microbial gene abundance score, namely M-score, separates the high COG-risk patients into two subpopulations (M<sub>high</sub> and M<sub>low</sub>) with higher accuracy in risk stratification than the current COG risk assessment, thus sparing a subset of high COG-risk patients from being subjected to traditional high-risk therapies. Mechanistically, the classification power of M-scores implies the effect of CREB over-activation, which may influence the critical genes involved in cellular proliferation, anti-apoptosis, and angiogenesis, affecting tumor cell proliferation survival and metastasis. Thus, intracellular microbiota abundance in neuroblastoma regulates intracellular signals to affect patients’ survival.</p> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-seq%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-seq</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetic+risk+stratification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetic risk stratification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22machine+learning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">machine learning</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microbial+signature%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microbial signature</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microbial-based+cancer+prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microbial-based cancer prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuroblastoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuroblastoma</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDCR+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DE025852 NIDCR NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDCR+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R21 DE030411 NIDCR NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA197903 NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA251848 NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Stucky A</b>, Gao L, Li SC, Tu L, Luo J, Huang X, Chen X, Li X, Park TH, Cai J, Kabeer MH, Plant AS, Sun L, Zhang X, Zhong JF. Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes. <em class='incite-journal-name' onclick='ShowInCiteJournal(9535);'>Front Cell Dev Biol</em> 2022;<b>10</b>:699144. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35356283' target='_blank'>35356283</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959432' target='_blank'>PMC8959432</a> DOI: <a href='https://dx.doi.org/10.3389/fcell.2022.699144' target='_blank'>10.3389/fcell.2022.699144</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fcell.2022.699144','35356283', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(7);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fcell.2022.699144' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/11466c815378809734e84c5d6f6de8f8/PMC8959432.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fcell.2022.699144');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9535);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/22/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/14/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/25/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.3389/fcell.2022.699144" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p><bold>Background:</bold> The mechanism of tumorigenicity potentially evolved in mesenchymal stem cells (MSCs) remains elusive, resulting in inconsistent clinical application efficacy. We hypothesized that subclones in MSCs contribute to their tumorgenicity, and we approached MSC-subclones at the single-cell level.</p><p><bold>Methods:</bold> MSCs were cultured in an osteogenic differentiation medium and harvested on days 12, 19, and 25 for cell differentiation analysis using Alizarin Red and followed with the single-cell transcriptome.</p><p><bold>Results:</bold> Single-cell RNA-seq analysis reveals a discrete cluster of MSCs during osteogenesis, including differentiation-resistant MSCs (DR-MSCs), differentiated osteoblasts (DO), and precursor osteoblasts (PO). The DR-MSCs population resembled cancer initiation cells and were subjected to further analysis of the yes associated protein 1 (YAP1) network. Verteporfin was also used for YAP1 inhibition in cancer cell lines to confirm the role of YAP1 in MSC--involved tumorigenicity. Clinical data from various cancer types were analyzed to reveal relationships among YAP1, OCT4, and CDH6 in MSC--involved tumorigenicity. The expression of cadherin 6 (CDH6), octamer-binding transcription factor 4 (OCT4), and YAP1 expression was significantly upregulated in DR-MSCs compared to PO and DO. YAP1 inhibition by Verteporfin accelerated the differentiation of MSCs and suppressed the expression of YAP1, CDH6, and OCT4. A survey of 56 clinical cohorts revealed a high degree of co-expression among CDH6, YAP1, and OCT4 in various solid tumors. YAP1 inhibition also down-regulated HeLa cell viability and gradually inhibited YAP1 nuclear localization while reducing the transcription of CDH6 and OCT4.</p><p><bold>Conclusions:</bold> We used single-cell sequencing to analyze undifferentiated MSCs and to discover a carcinogenic pathway in single-cell MSCs of differentiated resistance subclones.</p> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA197903 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA251848 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Li X</b>, Sun L, Stucky A, Tu L, Cai J, Chen X, Wu Z, Jiang X, Li SC. Reply to Schramm, L. Comment on “Li et al. BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. Diagnostics 2021, 11, 2364”. <em class='incite-journal-name' onclick='ShowInCiteJournal(7766);'>Diagnostics (Basel)</em> 2022;<b>12</b>:diagnostics12030617. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35328170' target='_blank'>35328170</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947584' target='_blank'>PMC8947584</a> DOI: <a href='https://dx.doi.org/10.3390/diagnostics12030617' target='_blank'>10.3390/diagnostics12030617</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/diagnostics12030617','35328170', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/diagnostics12030617' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/12b8dfce4d858595de20a6da53a071a9/PMC8947584.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/diagnostics12030617');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7766);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/07/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/25/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/10/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.3390/diagnostics12030617" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA197903 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA251848 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Zhang X</b>, Hou L, Li F, Zhang W, Wu C, Xiang L, Li J, Zhou L, Wang X, Xiang Y, Xiao Y, Li SC, Chen L, Ran Q, Li Z. Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury. <em class='incite-journal-name' onclick='ShowInCiteJournal(1572);'>Am J Cancer Res</em> 2022;<b>12</b>:1621-1638. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35198061' target='_blank'>35198061</a> DOI: <a href='https://dx.doi.org/10.7150/thno.64963' target='_blank'>10.7150/thno.64963</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.7150%2fthno.64963%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 18</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.7150%2fthno.64963')">Impact Index Per Article: 9.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7150/thno.64963','35198061', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.7150/thno.64963' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(1572);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/14/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/09/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.7150/thno.64963" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content"><b>Background:</b> Irradiation disrupts the vascular niche where hematopoietic stem cells (HSCs) reside, causing delayed hematopoietic reconstruction. The subsequent recovery of sinusoidal vessels is key to vascular niche regeneration and a prerequisite for hematopoietic reconstruction. We hypothesize that resident bone marrow macrophages (BM-Mφs) are responsible for repairing the HSC niche upon irradiation injury. <b>Methods:</b> We examined the survival and activation of BM-Mφs in C57BL/6 mice upon total body irradiation. After BM-Mφ depletion via injected clodronate-containing liposomes and irradiation injury, hematopoietic reconstruction and sinusoidal vascular regeneration were assessed with immunofluorescence and flow cytometry. Then enzyme-linked immunosorbent assay (ELISA) and flow cytometry were performed to analyze the contribution of VEGF-A released by BM-Mφs to the vascular restructuring of the HSC niche. VEGF-A-mediated signal transduction was assessed with transcriptome sequencing, flow cytometry, and pharmacology (agonists and antagonists) to determine the molecular mechanisms of Piezo1-mediated responses to structural changes in the HSC niche. <b>Results:</b> The depletion of BM-Mφs aggravated the post-irradiation injury, delaying the recovery of sinusoidal endothelial cells and HSCs. A fraction of the BM-Mφ population persisted after irradiation, with residual BM-Mφ exhibiting an activated M2-like phenotype. The expression of VEGF-A, which is essential for sinusoidal regeneration, was upregulated in BM-Mφs post-irradiation, especially CD206<sup>+</sup> BM-Mφs. The expression of mechanosensory ion channel Piezo1, a response to mechanical environmental changes induced by bone marrow ablation, was upregulated in BM-Mφs, especially CD206<sup>+</sup> BM-Mφs. Piezo1 upregulation was mediated by the effects of irradiation, the activation of Piezo1 itself, and the M2-like polarization induced by the phagocytosis of apoptotic cells. Piezo1 activation was associated with increased expression of VEGF-A and increased accumulation of NFATC1, NFATC2, and HIF-1α. The Piezo1-mediated upregulation in VEGF-A was suppressed by inhibiting the calcineurin/NFAT/HIF-1α signaling pathway. <b>Conclusion:</b> These findings reveal that BM-Mφs play a critical role in promoting vascular niche regeneration by sensing and responding to structural changes after irradiation injury, offering a potential target for therapeutic efforts to enhance hematopoietic reconstruction.</div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Piezo1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Piezo1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hematopoietic+reconstitution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hematopoietic reconstitution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22irradiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">irradiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22macrophages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">macrophages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sinusoidal+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sinusoidal regeneration</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Li X</b>, Sun L, Stucky A, Tu L, Cai J, Chen X, Wu Z, Jiang X, Li SC. <i>BDP1</i> Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. <em class='incite-journal-name' onclick='ShowInCiteJournal(7766);'>Diagnostics (Basel)</em> 2021;<b>11</b>:diagnostics11122364. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34943600' target='_blank'>34943600</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700758' target='_blank'>PMC8700758</a> DOI: <a href='https://dx.doi.org/10.3390/diagnostics11122364' target='_blank'>10.3390/diagnostics11122364</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fdiagnostics11122364%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 4</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fdiagnostics11122364')">Impact Index Per Article: 1.3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/diagnostics11122364','34943600', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(10);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/diagnostics11122364' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/06d4a1ef3d3f84dfa433133163d03ec5/PMC8700758.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/diagnostics11122364');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7766);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/16/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/16/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/29/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/03/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.3390/diagnostics11122364" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>Background: Neuroblastoma (N.B.) is the most common tumor in children. The gene <italic toggle="yes">BDP1</italic> (B Double Prime 1) plays a role in cancers but is less known in N.B. Thus, we conducted this study to investigate the value of <italic toggle="yes">BDP1</italic> mutations in N.B. prognosis. Methods: A dataset of 121 NB patients from the Cancer Genome Atlas database was used to analyze <italic toggle="yes">BDP1</italic> gene mutations by RNA sequencing. Kaplan-Meier estimates were performed for overall survival (O.S.) analysis on <italic toggle="yes">BDP1</italic> variants, and Cox’s proportional hazards regression model was used for multivariate analysis. Results: In 121 NB patients, we identified two variants of <italic toggle="yes">BDP1</italic> associated with N.B., located at chr5:71511131 and chr5:71510884. The prevalence of these <italic toggle="yes">BDP1</italic> variants, I1264M and V1347M, was 52.9% (64/121) and 45.5% (55/121), respectively. O.S. analysis showed a significant difference between subgroups with or without <italic toggle="yes">BDP1</italic> variants (<italic toggle="yes">p</italic> < 0.05). Multivariate analysis further revealed that <italic toggle="yes">BDP1</italic>ariants were independent prognostic variables in N.B. (<italic toggle="yes">p</italic> < 0.05). Conclusion: Our results suggest <italic toggle="yes">BDP1</italic> variants are associated with significantly improved clinical outcomes in N.B., thus providing clinicians with a new tool.</p> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BDP1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BDP1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuroblastoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuroblastoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prognostic+biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prognostic biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22variant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">variant</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDCR+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T90 DE021982 NIDCR NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Wang M</b>, Chen Y, Zhao Z, Weng S, Yang J, Liu S, Liu C, Yuan F, Ai B, Zhang H, Zhang M, Lu L, Yuan K, Yu Z, Mo B, Liu X, Gai C, Li Y, Lu R, Zhong Z, Zheng L, Feng G, Li SC, He J. A convenient polyculture system that controls a shrimp viral disease with a high transmission rate. <em class='incite-journal-name' onclick='ShowInCiteJournal(6800);'>Commun Biol</em> 2021;<b>4</b>:1276. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34764419' target='_blank'>34764419</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585955' target='_blank'>PMC8585955</a> DOI: <a href='https://dx.doi.org/10.1038/s42003-021-02800-z' target='_blank'>10.1038/s42003-021-02800-z</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1038%2fs42003-021-02800-z%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1038%2fs42003-021-02800-z')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s42003-021-02800-z','34764419', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s42003-021-02800-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/abbc1d513ec75eb96b6d8f5539f38204/PMC8585955.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s42003-021-02800-z');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(6800);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/29/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/19/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/30/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1038/s42003-021-02800-z" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>Developing ecological approaches for disease control is critical for future sustainable aquaculture development. White spot syndrome (WSS), caused by white spot syndrome virus (WSSV), is the most severe disease in cultured shrimp production. Culturing specific pathogen-free (SPF) broodstock is an effective and widely used strategy for controlling WSS. However, most small-scale farmers, who predominate shrimp aquaculture in developing countries, cannot cultivate SPF shrimp, as they do not have the required infrastructure and skills. Thus, these producers are more vulnerable to WSS outbreaks than industrial farms. Here we developed a shrimp polyculture system that prevents WSS outbreaks by introducing specific fish species. The system is easy to implement and requires no special biosecurity measures. The promotion of this system in China demonstrated that it allowed small-scale farmers to improve their livelihood through shrimp cultivation by controlling WSS outbreaks and increasing the production of ponds.</p><p>Wang et al. develop a shrimp polyculture system that prevents white spot syndrome outbreaks by introducing specific fish species. The system is easy to implement and requires no special biosecurity measures which makes it ideal for small-scale farmers.</p> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Sun M</b>, Xue X, Li L, Xu D, Li S, Li SC, Su Q. Ectosome biogenesis and release processes observed by using live-cell dynamic imaging in mammalian glial cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(19975);'>Quant Imaging Med Surg</em> 2021;<b>11</b>:4604-4616. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34737927' target='_blank'>34737927</a> DOI: <a href='https://dx.doi.org/10.21037/qims-20-1015' target='_blank'>10.21037/qims-20-1015</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.21037%2fqims-20-1015%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 11</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.21037%2fqims-20-1015')">Impact Index Per Article: 3.7</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.21037/qims-20-1015','34737927', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.21037/qims-20-1015' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19975);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/28/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/09/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.21037/qims-20-1015" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Ectosomes are recognized as shedding from the plasma membranes into the extracellular environment. Recent research has demonstrated that ectosomes are surrounded by phospholipid membranes containing lipid rafts and caveolae. Some ectosomes contain cytokines in the lumen and have high levels of phosphatidylserine exposed to the outer membrane. Intracellular vesicles share both characters with ectosomes. Why the plasma membrane-derived ectosomes have the same characteristics as intracellular vesicles remain largely unknown.</div><div class="abstract-label">Methods</div><div class="abstract-content">Using live-cell dynamic imaging, we recorded the process of ectosome biogenesis and release in primary cultured neural cells.</div><div class="abstract-label">Results</div><div class="abstract-content">Our results show two different ectosome release methods: slow-releasing and fast-releasing. In the slow-releasing, multiple ectosomes emerge almost simultaneously on the cell surface and are released by outward budding from the plasma membrane. In the fast releasing, ectosomes squeeze out of the membrane domain and pinch off from a cell's surface. Using ER-tracker for live-cell imaging, we directly observed the process that intracellular vesicles jump out of the plasma membrane for release. This type of ectosomes has a reverse array of membrane proteins and phospholipids compared to the plasma membrane. So ectosomes should be divided into two groups: plasma membrane-derived and intracellular membrane-derived ectosomes.</div><div class="abstract-label">Conclusions</div><div class="abstract-content">Both slow releasing and fast releasing EVs imply mechanisms of human diseases and for diagnostics and drug delivery.</div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ectosome+release%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ectosome release</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caveolae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">caveolae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cytokine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cytokine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22extracellular+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">extracellular vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22live-cell+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">live-cell imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microtubules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microtubules</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phosphatidylserine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phosphatidylserine</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Li F</b>, Zhang R, Hu C, Ran Q, Xiang Y, Xiang L, Chen L, Yang Y, Li SC, Zhang G, Li Z. Irradiation Haematopoiesis Recovery Orchestrated by IL-12/IL-12Rβ1/TYK2/STAT3-Initiated Osteogenic Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(9535);'>Front Cell Dev Biol</em> 2021;<b>9</b>:729293. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34540843' target='_blank'>34540843</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446663' target='_blank'>PMC8446663</a> DOI: <a href='https://dx.doi.org/10.3389/fcell.2021.729293' target='_blank'>10.3389/fcell.2021.729293</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3389%2ffcell.2021.729293%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3389%2ffcell.2021.729293')">Impact Index Per Article: 0.3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fcell.2021.729293','34540843', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fcell.2021.729293' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/d0ada7529f6718b234ecabd70c51144b/PMC8446663.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fcell.2021.729293');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9535);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/23/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/03/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/13/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.3389/fcell.2021.729293" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Purpose</div><p>Repairing the irradiation-induced osteogenic differentiation injury of bone marrow mesenchymal stem cells (BM-MSCs) is beneficial to recovering haematopoiesis injury in radiotherapy; however, its mechanism is elusive. Our study aimed to help meet the needs of understanding the effects of radiotherapy on BM-MSC osteogenic potential.</p><div class="abstract-label">Methods and Materials</div><p>Balb/c mice and the BM-MSCs were used to evaluate the irradiation-induced osteogenic differentiation injury <italic>in vivo</italic>. The cellular and molecular characterization were applied to determine the mechanism for recovery of irradiation-derived haematopoiesis injuries.</p><div class="abstract-label">Results</div><p>We report a functional role of IL-12 in acute irradiation hematopoietic injury recovery and intend to dissect the possible mechanisms through BM-MSC, other than the direct effect of IL-12 on hematopoietic stem and progenitor cells (HSPCs). Specifically, we show that early use of IL-12 enhanced the osteogenic differentiation of BM-MSCs through IL-12Rβ1/TYK2/STAT3 signaling; furthermore, IL-12 induced osteogenesis facilitated bone formation and irradiation hematopoiesis recovery when transplanted BM-MSCs in the femur of Balb/c mice. For the mechanism of action, we found that IL-12 receptor beta 1 (IL-12Rβ1) expression of irradiated BM-MSCs was upregulated rapidly, coincidentally consistent with early use of IL-12 induced osteogenic differentiation enhancement. IL-12Rβ1 and tyrosine kinase 2 gene (Tyk2) silencing experiments and phosphotyrosine of signal transducer and activator of transcription 3 (p-STAT3) suppression experiments indicated the IL-12Rβ1/TYK2/STAT3 signaling was essential in IL-12-induced osteogenic differentiation enhancement of BM-MSCs.</p><div class="abstract-label">Conclusion</div><p>These findings suggested that IL-12 may exert BM-MSCs-based hematopoietic recovery by repairing osteogenic differentiation abilities damages through IL-12Rβ1/TYK2/STAT3 signaling pathway post-irradiation.</p> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IL-12%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IL-12</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22haematopoiesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">haematopoiesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22irradiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">irradiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22recovery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">recovery</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Zhang XM</b>, Chen DG, Li SC, Zhu B, Li ZJ. Embryonic Origin and Subclonal Evolution of Tumor-Associated Macrophages Imply Preventive Care for Cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(4807);'>Cells</em> 2021;<b>10</b>:903. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/33919979' target='_blank'>33919979</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071014' target='_blank'>PMC8071014</a> DOI: <a href='https://dx.doi.org/10.3390/cells10040903' target='_blank'>10.3390/cells10040903</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fcells10040903%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 11</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fcells10040903')">Impact Index Per Article: 3.7</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/cells10040903','33919979', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/cells10040903' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/18024cf44b0040cae9dda437689e0068/PMC8071014.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/cells10040903');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4807);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/04/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/23/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/25/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/16/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.3390/cells10040903" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Macrophages are widely distributed in tissues and function in homeostasis. During cancer development, tumor-associated macrophages (TAMs) dominatingly support disease progression and resistance to therapy by promoting tumor proliferation, angiogenesis, metastasis, and immunosuppression, thereby making TAMs a target for tumor immunotherapy. Here, we started with evidence that TAMs are highly plastic and heterogeneous in phenotype and function in response to microenvironmental cues. We pointed out that efforts to tear off the heterogeneous "camouflage" in TAMs conduce to target de facto protumoral TAMs efficiently. In particular, several fate-mapping models suggest that most tissue-resident macrophages (TRMs) are generated from embryonic progenitors, and new paradigms uncover the ontogeny of TAMs. First, TAMs from embryonic modeling of TRMs and circulating monocytes have distinct transcriptional profiling and function, suggesting that the ontogeny of TAMs is responsible for the functional heterogeneity of TAMs, in addition to microenvironmental cues. Second, metabolic remodeling helps determine the mechanism of phenotypic and functional characteristics in TAMs, including metabolic bias from macrophages' ontogeny in macrophages' functional plasticity under physiological and pathological conditions. Both models aim at dissecting the ontogeny-related metabolic regulation in the phenotypic and functional heterogeneity in TAMs. We argue that gleaning from the single-cell transcriptomics on subclonal TAMs' origins may help understand the classification of TAMs' population in subclonal evolution and their distinct roles in tumor development. We envision that TAM-subclone-specific metabolic reprogramming may round-up with future cancer therapies. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer+target+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer target therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22heterogeneity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">heterogeneity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22origins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">origins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22subclonal+evolution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">subclonal evolution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22therapy-resistant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">therapy-resistant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor-associated+macrophages+(TAMs)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor-associated macrophages (TAMs)</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Embryo%2c+Mammalian%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Embryo, Mammalian/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single-Cell+Analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single-Cell Analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor-Associated+Macrophages%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor-Associated Macrophages/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Zeng Y</b>, Gao L, Luo X, Chen Y, Kabeer MH, Chen X, Stucky A, Loudon WG, Li SC, Zhang X, Zhong JF. Corrigendum to: Microfluidic enrichment of plasma cells improves treatment of multiple myeloma. <em class='incite-journal-name' onclick='ShowInCiteJournal(17037);'>Mol Oncol</em> 2021;<b>15</b>:317. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/33398937' target='_blank'>33398937</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782077' target='_blank'>PMC7782077</a> DOI: <a href='https://dx.doi.org/10.1002/1878-0261.12874' target='_blank'>10.1002/1878-0261.12874</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/1878-0261.12874','33398937', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/1878-0261.12874' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/176157f07ce115810652ffa1eda03eef/PMC7782077.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17037);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/04/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1002/1878-0261.12874" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Lee LX</b>, Li SC. Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective. <em class='incite-journal-name' onclick='ShowInCiteJournal(23605);'>World J Stem Cells</em> 2020;<b>12</b>:706-720. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/32952853' target='_blank'>32952853</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477658' target='_blank'>PMC7477658</a> DOI: <a href='https://dx.doi.org/10.4252/wjsc.v12.i8.706' target='_blank'>10.4252/wjsc.v12.i8.706</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.4252%2fwjsc.v12.i8.706%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 16</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.4252%2fwjsc.v12.i8.706')">Impact Index Per Article: 4.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.4252/wjsc.v12.i8.706','32952853', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.wjgnet.com/1948-0210/full/v12/i8/706.htm' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/forms/main/DownLoadFile.aspx?Type=Digital&TypeId=1&id=10.4252%2fwjsc.v12.i8.706&FilePath=3F3370D6C62884394292CF1F1CC53E3A1A107928CF7BC15FCC3DF098B3CE00157DA31FEB0395BA580FE3F290F5EFD1F3CC30CB94392A1014' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(23605);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/18/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/08/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/13/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/07/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.4252/wjsc.v12.i8.706" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>The development of single-cell subclones, which can rapidly switch from dormant to dominant subclones, occur in the natural pathophysiology of multiple myeloma (MM) but is often "pressed" by the standard treatment of MM. These emerging subclones present a challenge, providing reservoirs for chemoresistant mutations. Technological advancement is required to track MM subclonal changes, as understanding MM's mechanism of evolution at the cellular level can prompt the development of new targeted ways of treating this disease. Current methods to study the evolution of subclones in MM rely on technologies capable of phenotypically and genotypically characterizing plasma cells, which include immunohistochemistry, flow cytometry, or cytogenetics. Still, all of these technologies may be limited by the sensitivity for picking up rare events. In contrast, more incisive methods such as RNA sequencing, comparative genomic hybridization, or whole-genome sequencing are not yet commonly used in clinical practice. Here we introduce the epidemiological diagnosis and prognosis of MM and review current methods for evaluating MM subclone evolution, such as minimal residual disease/multiparametric flow cytometry/next-generation sequencing, and their respective advantages and disadvantages. In addition, we propose our new single-cell method of evaluation to understand MM's mechanism of evolution at the molecular and cellular level and to prompt the development of new targeted ways of treating this disease, which has a broad prospect.</p> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+myeloma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple myeloma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single-cell+transcriptome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single-cell transcriptome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Subclonal+evolution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Subclonal evolution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+stem+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer stem cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Systemic+tracking+of+single-cell+landscape%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Systemic tracking of single-cell landscape</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Artificial+intelligence+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Artificial intelligence medicine</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Li SC</b>, Kabeer MH. Autologous Splenocyte Reinfusion Improves Antibody-Mediated Immune Response to the 23-Valent Pneumococcal Polysaccharide-Based Vaccine in Splenectomized Mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(3676);'>Biomolecules</em> 2020;<b>10</b>:biom10050704. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/32369978' target='_blank'>32369978</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277809' target='_blank'>PMC7277809</a> DOI: <a href='https://dx.doi.org/10.3390/biom10050704' target='_blank'>10.3390/biom10050704</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fbiom10050704%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fbiom10050704')">Impact Index Per Article: 1.3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/biom10050704','32369978', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(17);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/biom10050704' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/01170b1976497a2822e8deb9bf63dc4c/PMC7277809.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/biom10050704');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3676);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/15/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/28/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/28/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/17/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.3390/biom10050704" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>Common clinical options, currently, for necessary splenectomy are vaccinations and antibiotic prophylaxis. However, despite these two adjuncts, there still occur numerous cases of overwhelming post-splenectomy infection. To examine whether reperfusion of critical splenic lymphocytes could boost immune response, we harvested splenic lymphocytes, reperfused the autologous lymphocytes, and then administered a pneumococcal vaccine (PNEUMOVAX<sup>®</sup>23, i.e., PPSV23) in splenectomized mice. We found that splenectomy impaired the immune response in the splenectomized group compared to the non-splenectomized group; the splenectomized group with lymphocyte reinfusion had a higher response to polysaccharide vaccination based on antibody titer than the splenectomized group without lymphocyte reinfusion. The sham group with the native spleen had the most elevated antibody titer against the PPSV23 polysaccharide antigen. This may be additive, resulting from contributions of the splenic structure, along with the phagocytic function of the spleen and its constituent cells affecting the antibody response. Reinfusion of splenic lymphocytes may enhance immunity without the complications associated with splenic fragment autotransplantation, which never gained acceptance. This technique is safe and simple since the splenic lymphocytes are autologous and, therefore, not self-reactive, and very similar to autologous blood transfusion. This concept may be beneficial in cases of unavoidable splenectomy, especially in pediatric cases.</p> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antibody+response+to+PNEUMOVAX%c2%ae23+vaccines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antibody response to PNEUMOVAX®23 vaccines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22reinfusion+of+autologous+splenocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">reinfusion of autologous splenocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22splenectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">splenectomy</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Bacterial%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Bacterial/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunogenicity%2c+Vaccine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunogenicity, Vaccine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphocyte+Transfusion%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphocyte Transfusion/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pneumococcal+Vaccines%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pneumococcal Vaccines/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spleen%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spleen/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spleen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spleen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Splenectomy%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Splenectomy/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptococcus+pneumoniae%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptococcus pneumoniae/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vaccination%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vaccination/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA164509 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIEHS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 ES021801 NIEHS NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Xiang LX</b>, Ran Q, Chen L, Xiang Y, Li FJ, Zhang XM, Xiao YN, Zou LY, Zhong JF, Li SC, Li ZJ. CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation. <em class='incite-journal-name' onclick='ShowInCiteJournal(23605);'>World J Stem Cells</em> 2020;<b>12</b>:222-240. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/32266053' target='_blank'>32266053</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118287' target='_blank'>PMC7118287</a> DOI: <a href='https://dx.doi.org/10.4252/wjsc.v12.i3.222' target='_blank'>10.4252/wjsc.v12.i3.222</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.4252%2fwjsc.v12.i3.222%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 4</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.4252%2fwjsc.v12.i3.222')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.4252/wjsc.v12.i3.222','32266053', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.wjgnet.com/1948-0210/full/v12/i3/222.htm' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/forms/main/DownLoadFile.aspx?Type=Digital&TypeId=1&id=10.4252%2fwjsc.v12.i3.222&FilePath=8182250771E135FE48C1CFDB1A77EE9D20DE0630D96ECF7C23130F3A2B1B3DE075CAA585FB819944B310DD09BC0D650B6DECE1FCD6E50A17' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(23605);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/23/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/29/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/15/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/06/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.4252/wjsc.v12.i3.222" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="article-section-title-1">BACKGROUND</div><p>Radiation induces rapid bone loss and enhances bone resorption and adipogenesis, leading to an increased risk of bone fracture. There is still a lack of effective preventive or therapeutic method for irradiation-induced bone injury. Receptor activator of nuclear factor κB ligand (RANKL) provides the crucial signal to induce osteoclast differentiation and plays an important role in bone resorption. However, the mechanisms of radiation-induced osteoporosis are not fully understood.</p> <div class="article-section-title-1">AIM</div><p>To investigate the role of CR6-interacting factor-1 (Crif1) in osteoclastogenesis after radiation and its possible mechanism.</p> <div class="article-section-title-1">METHODS</div><p>C57BL/6 mice were exposed to Co-60 gamma rays and received 5 Gy of whole-body sublethal irradiation at a rate of 0.69 Gy/min. For <i>in vitro</i> study, mouse bone marrow mesenchymal stem/stromal cells (BM-MSCs) were irradiated with Co-60 at a single dose of 9 Gy. For osteoclast induction, monocyte-macrophage RAW264.7 cells were cocultured with mouse BM-MSCs for 7 d. ClusPro and InterProSurf were used to investigate the interaction interface in Crif1 and protein kinase cyclic adenosine monophosphate (cAMP)-activited catalytic subunit alpha complex. Virtual screening using 462608 compounds from the Life Chemicals database around His120 of Crif1 was carried out using the program Autodock_vina. A tetrazolium salt (WST-8) assay was carried out to study the toxicity of compounds to different cells, including human BM-MSCs, mouse BM-MSCs, and Vero cells.</p> <div class="article-section-title-1">RESULTS</div><p>Crif1 expression increased in bone marrow cells after radiation in mice. Overexpression of Crif1 in mouse BM-MSCs and radiation exposure could increase RANKL secretion and promote osteoclastogenesis <i>in vitro</i>. Deletion of Crif1 in BM-MSCs could reduce both adipogenesis and RANKL expression, resulting in the inhibition of osteoclastogenesis. Deletion of Crif1 in RAW264.7 cells did not affect the receptor activator of nuclear factor κB expression or osteoclast differentiation. Following treatment with protein kinase A (PKA) agonist (forskolin) and inhibitor (H-89) in mouse BM-MSCs, Crif1 induced RANKL secretion <i>via</i> the cAMP/PKA pathway. Moreover, we identified the Crif1-protein kinase cyclic adenosine monophosphate-activited catalytic subunit alpha interaction interface by <i>in silico</i> studies and shortlisted interface inhibitors through virtual screening on Crif1. Five compounds dramatically suppressed RANKL secretion and adipogenesis by inhibiting the cAMP/PKA pathway.</p> <div class="article-section-title-1">CONCLUSION</div><p>Crif1 promotes RANKL expression <i>via</i> the cAMP/PKA pathway, which induces osteoclastogenesis by binding to receptor activator of nuclear factor κB on monocytes-macrophages in the mouse model. These results suggest a role for Crif1 in modulating osteoclastogenesis and provide insights into potential therapeutic strategies targeting the balance between osteogenesis and adipogenesis for radiation-induced bone injury.</p> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Irradiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Irradiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+marrow%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone marrow</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+stem+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal stem cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monocyte+macrophage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monocyte macrophage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> Implementation and Validation of the Roche Light Cycler 480 96-Well Plate Platform as a Real-Time PCR Assay for the Quantitative Detection of Cytomegalovirus (CMV) in Clinical Specimens Using the Luminex MultiCode ASRs System. <em class='incite-journal-name' onclick='ShowInCiteJournal(168176);'>Med Sci (Basel)</em> 2020;<b>8</b>:medsci8010014. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/32168800' target='_blank'>32168800</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151591' target='_blank'>PMC7151591</a> DOI: <a href='https://dx.doi.org/10.3390/medsci8010014' target='_blank'>10.3390/medsci8010014</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/medsci8010014','32168800', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/medsci8010014' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/92b8b58dcddf66904260eed366cffe02/PMC7151591.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/medsci8010014');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168176);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/17/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/03/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/07/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.3390/medsci8010014" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>Allogenic stem-cell therapies benefit patients in the treatment of multiple diseases; however, the side effects of stem-cell therapies (SCT) derived from the concomitant use of immune suppression agents often include triggering infection diseases. Thus, analysis is required to improve the detection of pathogen infections in SCT. We develop a polymerase chain reaction (PCR)-based methodology for the qualitative real-time DNA detection of cytomegalovirus (CMV), with reference to herpes simplex virus types 1 (HSVI), Epstein–Barr virus (EBV), and varicella-zoster virus (VZV) in blood, urine, solid tissues, and cerebrospinal fluid. This real-time PCR of 96-well plate format provides a rapid framework as required by the Food and Drug Administration (FDA) for clinical settings, including the processing of specimens, reagent handling, special safety precautions, quality control criteria and analytical accuracy, precisely reportable range (analyst measurement range), reference range, limit of detection (LOD), analytical specificity established by interference study, and analyte stability. Specifically, we determined the reportable range (analyst measurement range) with the following criteria: CMV copies ≥200 copies/mL; report copy/mL value; CMV copies ≤199 copies/mL; report detected but below quantitative range; CMV copies = 0 with report <200 copies/mL. That is, with reference range, copy numbers (CN) per milliliter (mL) of the LOD were determined by standard curves that correlated Ct value and calibrated standard DNA panels. The three repeats determined that the measuring range was 1E2~1E6 copies/mL. The standard curves show the slopes were within the range −2.99 to −3.65 with <italic>R<sup>2</sup></italic> ≥ 0.98. High copy (HC) controls were within 0.17–0.18 log differences of DNA copy numbers; (2) low copy (LC) controls were within 0.17–0.18 log differences; (3) LOD was within 0.14–0.15 log differences. As such, we set up a fast, simple, inexpensive, sensitive, and reliable molecular approach for the qualitative detection of CMV pathogens. <italic>Conclusion</italic>: This real-time PCR of the 96-well plate format provides a rapid framework as required by the FDA for clinical settings.</p> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Luminex+MultiCode+ASRs+System%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Luminex MultiCode ASRs System</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PCR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PCR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Roche+Light+Cycler+480+PCR+device%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Roche Light Cycler 480 PCR device</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cytomegalovirus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cytomegalovirus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22infection+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">infection diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22real-time+PCR+of+96-well+plate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">real-time PCR of 96-well plate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22stem-cell+therapies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">stem-cell therapies</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Zhang J</b>, Su Q, Loudon WG, Lee KL, Luo J, Dethlefs BA, Li SC. Breathing Signature as Vitality Score Index Created by Exercises of Qigong: Implications of Artificial Intelligence Tools Used in Traditional Chinese Medicine. <em class='incite-journal-name' onclick='ShowInCiteJournal(171926);'>J Funct Morphol Kinesiol</em> 2019;<b>4</b>:71. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/31853512' target='_blank'>31853512</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919646' target='_blank'>PMC6919646</a> DOI: <a href='https://dx.doi.org/10.3390/jfmk4040071' target='_blank'>10.3390/jfmk4040071</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fjfmk4040071%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fjfmk4040071')">Impact Index Per Article: 1.2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/jfmk4040071','31853512', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(20);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/jfmk4040071' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/490c6b19b548e4c8227bd381fbaa399b/PMC6919646.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/jfmk4040071');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(171926);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://login.mdpi.com/login?_target_path=https%3A%2F%2Fsusy.mdpi.com%2Fuser%2Flogin%3FauthAll%3Dtrue' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/04/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/27/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/14/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.3390/jfmk4040071" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Rising concerns about the short- and long-term detrimental consequences of administration of conventional pharmacopeia are fueling the search for alternative, complementary, personalized, and comprehensive approaches to human healthcare. Qigong, a form of Traditional Chinese Medicine, represents a viable alternative approach. Here, we started with the practical, philosophical, and psychological background of Ki (in Japanese) or Qi (in Chinese) and their relationship to Qigong theory and clinical application. Noting the drawbacks of the current state of Qigong clinic, herein we propose that to manage the unique aspects of the Eastern 'non-linearity' and 'holistic' approach, it needs to be integrated with the Western "linearity" "one-direction" approach. This is done through developing the concepts of "Qigong breathing signatures," which can define our life breathing patterns associated with diseases using machine learning technology. We predict that this can be achieved by establishing an artificial intelligence (AI)-Medicine training camp of databases, which will integrate Qigong-like breathing patterns with different pathologies unique to individuals. Such an integrated connection will allow the AI-Medicine algorithm to identify breathing patterns and guide medical intervention. This unique view of potentially connecting Eastern Medicine and Western Technology can further add a novel insight to our current understanding of both Western and Eastern medicine, thereby establishing a vitality score index (VSI) that can predict the outcomes of lifestyle behaviors and medical conditions. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AI+Medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AI Medicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AI+deep+learning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AI deep learning</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qigong%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qigong</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22breathing+signature%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">breathing signature</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22holistic+care%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">holistic care</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22telomerase+activity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">telomerase activity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tissue+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tissue microenvironment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22traditional+Chinese+medicine+(TCM)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">traditional Chinese medicine (TCM)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vitality+score+index%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vitality score index</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">F32 CA071326 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> CRIF1 as a potential target to improve the radiosensitivity of osteosarcoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(19666);'>Proc Natl Acad Sci U S A</em> 2019;<b>116</b>:20511-20516. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/31548420' target='_blank'>31548420</a> DOI: <a href='https://dx.doi.org/10.1073/pnas.1906578116' target='_blank'>10.1073/pnas.1906578116</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1073%2fpnas.1906578116%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 8</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1073%2fpnas.1906578116')">Impact Index Per Article: 1.6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1073/pnas.1906578116','31548420', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1073/pnas.1906578116' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19666);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/03/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1073/pnas.1906578116" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Resistance to ionizing radiation (IR), which is a conventional treatment for osteosarcoma that cannot be resected, undermines the efficacy of this therapy. However, the mechanism by which IR induces radioresistance in osteosarcoma is not defined. Here, we report that CR6-interacting factor-1 (CRIF1) is highly expressed in osteosarcoma and undergoes nuclear-cytoplasmic shuttling of cyclin-dependent kinase 2 (CDK2) after IR. Osteosarcoma cells lacking CRIF1 show increased sensitivity to IR, which is associated with delayed DNA damage repair, inactivated G1/S checkpoint, and mitochondrial dysfunction. CRIF1 interacts with the DNA damage checkpoint regulator CDK2, and CRIF1 and CDK2 colocalize in the nucleus after IR. Nuclear localization of CDK2 is associated with phosphorylation changes that promote DNA repair and activation of the G1/S checkpoint. CRIF1 knockdown synergized with IR in an in vivo osteosarcoma model, leading to tumor regression. Based on these findings, we identify CRIF1 as a potential therapeutic target in osteosarcoma that can increase the efficacy of radiotherapy. More broadly, our findings may provide insights into the mechanism for other types of radioresistant cancers and be exploited for therapeutic ends.</div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CDK2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CDK2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CRIF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CRIF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteosarcoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteosarcoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22radioresistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">radioresistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22radiotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">radiotherapy</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Miao Y</b>, Chen Z, Li SC. Functional endoscopy techniques for tracking stem cell fate. <em class='incite-journal-name' onclick='ShowInCiteJournal(19975);'>Quant Imaging Med Surg</em> 2019;<b>9</b>:510-520. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/31032197' target='_blank'>31032197</a> DOI: <a href='https://dx.doi.org/10.21037/qims.2019.02.12' target='_blank'>10.21037/qims.2019.02.12</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.21037%2fqims.2019.02.12%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.21037%2fqims.2019.02.12')">Impact Index Per Article: 0.6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.21037/qims.2019.02.12','31032197', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.21037/qims.2019.02.12' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19975);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/16/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.21037/qims.2019.02.12" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Tracking and monitoring implanted stem cells are essential to maximize benefits and to minimize the side effects of stem cell therapy for personalized or "precision" medicine. Previously, we proposed a comprehensive biological Global Positioning System (bGPS) to track and monitor stem cells <i>in vivo</i>. Magnetic resonance imaging (MRI), positron emission tomography (PET), bioluminescent imaging, fluorescence imaging, and single-photon emission computerized tomography (SPECT) have been utilized to track labeled or genetically-modified cells <i>in vivo</i> in rats and humans. A large amount of research has been dedicated to the design of reporter genes and molecular probes for imaging and the visualization of the biodistribution of the implanted cells in high resolution. On the other hand, optical-based functional imaging, such as photoacoustic imaging (PAI), optical coherence tomography (OCT), and multiphoton microscopy (MPM), has been implemented into small endoscopes to image cells inside the body. The optical fiber allows miniaturization of the imaging probe while maintaining high resolution due to light-based imaging. Upon summarizing the recent progress in the design and application of functional endoscopy techniques for stem cell monitoring, we offer perspectives for the future development of endoscopic molecular imaging tools for <i>in vivo</i> tracking of spatiotemporal changes in subclonal evolution at the single cell level.</div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoscopy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoscopy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biological+GPS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biological GPS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+tracking%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell tracking</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22stem+cell+research%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">stem cell research</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Chen X</b>, Wen Q, Stucky A, Zeng Y, Gao S, Loudon WG, Ho HW, Kabeer MH, Li SC, Zhang X, Zhong JF. Relapse pathway of glioblastoma revealed by single-cell molecular analysis. <em class='incite-journal-name' onclick='ShowInCiteJournal(4630);'>Carcinogenesis</em> 2019;<b>39</b>:931-936. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/29718126' target='_blank'>29718126</a> DOI: <a href='https://dx.doi.org/10.1093/carcin/bgy052' target='_blank'>10.1093/carcin/bgy052</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1093%2fcarcin%2fbgy052%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 24</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1093%2fcarcin%2fbgy052')">Impact Index Per Article: 4.8</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/carcin/bgy052','29718126', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/carcin/bgy052' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4630);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/12/2017]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/23/2018]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/15/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1093/carcin/bgy052" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Glioblastoma multiforme (GBM) remains an incurable brain tumor. The highly malignant behavior of GBM may, in part, be attributed to its intraclonal genetic and phenotypic diversity (subclonal evolution). Identifying the molecular pathways driving GBM relapse may provide novel, actionable targets for personalized diagnosis, characterization of prognosis and improvement of precision therapy. We screened single-cell transcriptomes, namely RNA-seq data of primary and relapsed GBM tumors from a patient, to define the molecular profile of relapse. Characterization of hundreds of individual tumor cells identified three mutated genes within single cells, involved in the RAS/GEF GTP-dependent signaling pathway. The identified molecular pathway was further verified by meta-analysis of RNA-seq data from more than 3000 patients. This study showed that single-cell molecular analysis overcomes the inherent heterogeneity of bulk tumors with respect to defining tumor subclonal evolution relevant to GBM relapse.</div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Li SC</b>, Rangel AD, Kabeer MH. Precision Technique for Splenectomy Limits Mouse Stress Responses for Accurate and Realistic Measurements for Investigating Inflammation and Immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(163510);'>Bio Protoc</em> 2019;<b>9</b>:e3317. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/31497622' target='_blank'>31497622</a> DOI: <a href='https://dx.doi.org/10.21769/bioprotoc.3317' target='_blank'>10.21769/bioprotoc.3317</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.21769%2fbioprotoc.3317%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.21769%2fbioprotoc.3317')">Impact Index Per Article: 1.2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.21769/bioprotoc.3317','31497622', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.21769/bioprotoc.3317' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(163510);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/21/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.21769/bioprotoc.3317" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Splenectomy in an animal model requires a standardized technique utilizing best practice to avoid variability which can result in adverse impact to the animal resulting in flawed physiologic responses simply due to technique rather than to the studied variables. In the case of the spleen, often investigators are analyzing the animal immune or inflammatory responses. Surgical splenectomy involves many variables from the training and expertise of the surgeon, which directly correlates to surgical technique to the length of operation and ease of the procedure. This operation, in turn, impacts blood loss and insensible fluid losses, sterile technique, unintended trauma to the spleen and surrounding organs, the length of the incision and the duration of the operation with more prolonged exposure to anesthetic agents. All these variables ultimately play a significant role in the experiment since they directly affect the response of the model in terms of inflammation, immune activation, or even suppression. Undesired variables such as these go unnoticed and lead to inaccurate and misleading data.</div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animal+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animal model</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autologous+cell+reperfusion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autologous cell reperfusion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blunt+trauma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blunt trauma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Critical+care%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Critical care</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infectious+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infectious diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Splenectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Splenectomy</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Li SC</b>, Stucky A, Chen X, Kabeer MH, Loudon WG, Plant AS, Torno L, Nangia CS, Cai J, Zhang G, Zhong JF. Single-cell transcriptomes reveal the mechanism for a breast cancer prognostic gene panel. <em class='incite-journal-name' onclick='ShowInCiteJournal(172491);'>Oncotarget</em> 2018;<b>9</b>:33290-33301. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/30279960' target='_blank'>30279960</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161791' target='_blank'>PMC6161791</a> DOI: <a href='https://dx.doi.org/10.18632/oncotarget.26044' target='_blank'>10.18632/oncotarget.26044</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.18632%2foncotarget.26044%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 10</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.18632%2foncotarget.26044')">Impact Index Per Article: 1.7</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.18632/oncotarget.26044','30279960', '00002131')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.18632/oncotarget.26044' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/48a1083522051046b00c0888efb95290/PMC6161791.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.18632/oncotarget.26044');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(172491);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/10/2018]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/13/2018]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/12/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Imported: 08/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.18632/oncotarget.26044" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The clinical benefits of the MammaPrint® signature for breast cancer is well documented; however, how these genes are related to cell cycle perturbation have not been well determined. Our single-cell transcriptome mapping (algorithm) provides details into the fine perturbation of all individual genes during a cell cycle, providing a view of the cell-cycle-phase specific landscape of any given human genes. Specifically, we identified that 38 out of the 70 (54%) MammaPrint® signature genes are perturbated to a specific phase of the cell cycle. The MammaPrint® signature panel derived its clinical prognosis power from measuring the cell cycle activity of specific breast cancer samples. Such cell cycle phase index of the MammaPrint® signature suggested that measurement of the cell cycle index from tumors could be developed into a prognosis tool for various types of cancer beyond breast cancer, potentially improving therapy through targeting a specific phase of the cell cycle of cancer cells. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+cycle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell cycle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+cycle+phase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell cycle phase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell-cycle-staged+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell-cycle-staged therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22single-cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">single-cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transcriptome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transcriptome</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA164509 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIEHS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 ES021801 NIEHS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDCR+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T90 DE021982 NIDCR NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> 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id="RootHolder_UserAchieveContainer" style="padding-bottom: 20px;"> </div> </div> <div class="cl"></div> </div> </div> </div> <table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="RootHolder_LeftLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1"> (65 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="65" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2"> (65 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="65" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>

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