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Duloxetine (Cymbalta, Drizalma Sprinkle): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
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16px;font-size:14px;font-family:Roboto,Arial,Helvetica,sans-serif;line-height:36px;letter-spacing:.5px;text-transform:uppercase;-webkit-box-shadow:none;box-shadow:none;text-decoration:none;color:#fff;background-color:#00bcd4}.webmd-input__inner,.webmd-label,.webmd-label.labelup{font-weight:400;letter-spacing:normal}.webmd-button.material:active,.webmd-button.material:focus,.webmd-button.material:hover{color:#fff;background-color:#0097a7}.webmd-button.material.is-shadow{-webkit-box-shadow:0 2px 4px 0 rgba(0,0,0,.3);box-shadow:0 2px 4px 0 rgba(0,0,0,.3)}.webmd-button.material.is-capitalized{text-transform:capitalize}.webmd-button:hover{background-color:#00588c;color:#fff}.webmd-button+.webmd-button{margin-left:.625rem}.webmd-button::-moz-focus-inner{border-style:none}.webmd-button.is-icon{padding-left:1rem;padding-right:1rem}.webmd-button 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.vn-none{display:none!important}}.vn-wrapper .vn-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;height:3rem;margin:0 auto;max-width:77.5rem;z-index:1}@media(min-width:64.0625rem){.vn-wrapper .vn-container{height:4.6875rem}}.vn-wrapper .vn-container.lite{max-width:100%}@media(min-width:64.0625rem){.vn-wrapper .vn-container.lite{height:3.5rem}}.vn-wrapper .vn-menu-btn{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background:none;border:0;color:#fff;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;height:100%;line-height:1;padding:0}.vn-wrapper .vn-menu-btn:not(.lite){margin-right:1.166875rem}@media(min-width:64.0625rem){.vn-wrapper .vn-menu-btn:not(.lite){margin-right:0}}.vn-wrapper .vn-menu-btn i{font-size:2.25rem;width:2.25rem;overflow:hidden}.vn-wrapper .vn-menu-btn svg{fill:currentColor;pointer-events:none}.vn-wrapper .vn-menu-btn.vn-search i{font-size:1.875rem;width:1.875rem}.vn-wrapper .vn-menu-btn.vn-search:not(.lite){margin-right:0}@media(min-width:64.0625rem){.vn-wrapper .vn-menu-btn.vn-search:not(.lite) i{font-size:1.625rem;width:1.625rem}}.vn-wrapper .vn-menu-btn.vn-search.lite i{font-size:2rem;width:2rem}.vn-wrapper .vn-logo-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:-webkit-box;display:-ms-flexbox;display:flex}.vn-wrapper .vn-logo-container .vn-logo-div{height:.9375rem;margin:0 .625rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo-div{height:1.5625rem;margin:0 1.25rem}}.vn-wrapper .vn-logo-container .vn-logo,.vn-wrapper .vn-logo-container .vn-prog-logo{line-height:1}.vn-wrapper .vn-logo-container .vn-logo img,.vn-wrapper .vn-logo-container .vn-prog-logo img{display:block;height:1.3125rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo img,.vn-wrapper .vn-logo-container .vn-prog-logo img{height:1.625rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo img:not(.lite){width:7.25rem}}.vn-wrapper .vn-logo-container.with-program .vn-logo img{height:.875rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container.with-program .vn-logo img{height:1.4375rem}}.vn-wrapper .vn-logo-container.with-program .vn-prog-logo img{height:.9375rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container.with-program .vn-prog-logo img{height:1.5625rem}}.vn-wrapper .vn-links{background:#f9f9fc;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;height:calc(100vh - 3rem);left:-140vw;overflow:auto;padding:.5rem;position:fixed;top:3rem;-webkit-transition:left .5s ease;transition:left .5s ease;width:100%;z-index:100}@media(min-width:37.5rem){.vn-wrapper .vn-links{max-width:25rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-links.lite{height:calc(100vh - 3.5rem);top:3.5rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-links:not(.lite){background:none;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row;height:100%;left:0;max-width:100%;overflow:visible;padding:0;position:relative;top:0}}.vn-wrapper .vn-links.open{left:0}.vn-wrapper .vn-links.open.vn-slide-out{left:-100vw}@media(min-width:37.5rem){.vn-wrapper .vn-links.open.vn-slide-out{left:0}}.vn-wrapper .vn-links .vn-search-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex;height:3rem;margin-bottom:.25rem;-webkit-box-ordinal-group:0;-ms-flex-order:-1;order:-1}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-search-wrapper:not(.lite){background:#fff;border:1px solid #c6cedb;border-radius:5px;opacity:0;-webkit-box-ordinal-group:2;-ms-flex-order:1;order:1;position:absolute;right:2.8125rem;top:.8125rem;width:38%;-webkit-transition:all .3s ease;transition:all .3s 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.vn-menu-section{left:0;opacity:1;visibility:visible}}@media(min-width:81.25rem){.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:not(:nth-child(7)){margin-right:1rem}}.vn-wrapper .vn-links .vn-menu-section{background:#f9f9fc;height:calc(100vh - 3rem);right:-140vw;overflow:auto;padding:0 1.5rem 6.25rem 1.5rem;position:fixed;top:3rem;-webkit-transition:all .5s ease;transition:all .5s ease;width:100%;z-index:10}.vn-wrapper .vn-links .vn-menu-section.lite{height:calc(100vh - 3.5rem);top:3.5rem}@media(min-width:37.5rem){.vn-wrapper .vn-links .vn-menu-section{max-width:25rem;left:-140vw;right:auto}.vn-wrapper .vn-links .vn-menu-section.open{left:0;right:auto}}.vn-wrapper .vn-links .vn-menu-section.open{right:0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header{-webkit-box-align:center;-ms-flex-align:center;align-items:center;border-bottom:1px solid #c6cedb;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;padding:.75rem 0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header .nav-title{color:#1b1b1b;font-size:1.25rem;line-height:1;margin:0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header a{color:#3557ff;font-weight:400;text-decoration:none}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header a img{margin-right:.5rem;width:.8125rem}.vn-wrapper .vn-links .vn-menu-section ul{margin:.75rem 0;list-style:none;padding:0}.vn-wrapper .vn-links .vn-menu-section ul li{font-size:1.125rem;font-weight:400}.vn-wrapper .vn-links .vn-menu-section ul li a{color:#1b1b1b;display:block;padding:.75rem 0;text-decoration:none}.vn-wrapper .vn-links .vn-menu-section ul li a:hover{color:#3557ff}.vn-wrapper .vn-links .vn-menu-section ul li hr{border:1px solid #c6cedb}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-menu-section:not(.lite){background:#fff;border-radius:0 0 5px 5px;border-top:0;left:-20px;margin-left:-3.75rem;max-width:none;height:auto;opacity:0;padding:1.875rem 2.875rem;position:absolute;top:4.6875rem;width:18.75rem;visibility:hidden}.vn-wrapper .vn-links .vn-menu-section:not(.lite) hr{display:none}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul{margin:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li{border-bottom:1px solid #c6cedb}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li:last-of-type{border-bottom:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li.vn-see-all a{-webkit-box-align:baseline;-ms-flex-align:baseline;align-items:baseline;color:#3557ff;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:start;-ms-flex-pack:start;justify-content:flex-start}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li.vn-see-all a img{height:.75rem;margin-right:.5rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1{width:60.9375rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul{-webkit-columns:4;-moz-columns:4;columns:4;-webkit-column-gap:2.875rem;-moz-column-gap:2.875rem;column-gap:2.875rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(7),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(14),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(21){border-bottom:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3{width:35rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul{-webkit-columns:2;-moz-columns:2;columns:2;-webkit-column-gap:2.875rem;-moz-column-gap:2.875rem;column-gap:2.875rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul li:nth-child(8),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul li:nth-child(16){border-bottom:0}}@media(min-width:64.0625rem)and (max-width:81.25rem){.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1{margin-left:-8.75rem}}.vn-wrapper .vn-links .vn-back{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background:none;border:0;color:#3557ff;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;padding:1rem 0}.vn-wrapper .vn-links .vn-back i{font-size:.75rem;margin-right:.3125rem}.vn-wrapper .vn-links .vn-actions{margin-top:1rem}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-actions:not(.lite){-webkit-box-align:center;-ms-flex-align:center;align-items:center;border-left:1px solid #cccce7;display:-webkit-box;display:-ms-flexbox;display:flex;margin:1.1875rem 0;padding-left:1.25rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe{border-left:none}}.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe .vn-signin{padding-left:.9375rem}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe .vn-signin{padding-left:0}}.vn-wrapper .vn-links .vn-actions .vn-signin{color:#3557ff;font-weight:600;padding:0 1.5rem;text-decoration:none}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-actions .vn-signin:not(.lite){-webkit-box-align:center;-ms-flex-align:center;align-items:center;color:#fff;display:-webkit-box;display:-ms-flexbox;display:flex;font-size:1.0625rem;padding:0;margin:0 .9375rem;-webkit-transition:all .3s ease;transition:all .3s ease}}.vn-wrapper .vn-links .vn-actions .vn-loggedin{background:none;border:0;color:#3557ff;font-weight:600;height:3rem;padding:0 1.5rem;text-decoration:none}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-actions .vn-loggedin:not(.lite){-webkit-box-align:center;-ms-flex-align:center;align-items:center;color:#fff;display:-webkit-box;display:-ms-flexbox;display:flex;font-size:0;padding:0;margin:0 1.25rem}.vn-wrapper .vn-links .vn-actions 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.left-nav-toggle:before{content:""}.main-container-2{padding-left:0;width:calc(100% - 312px)}}@media screen and (max-width:47.938em){body{padding:5rem 0 0}main{padding:0 .625rem}.main-container-1{right:0;width:75vw}.main-container-2{padding:0;width:100%}.main-container-3{display:block;width:100%}}@media screen and (max-width:77.438em){main{padding:0 1.25rem}}@media print{.ad,.article [data-e2e=social-sharebar],.global-nav__wrapper>:not(.global-nav__logo),[data-js=global-container-2],[data-js=global-footer],[data-js=main-container-1],[data-js=main-container-2] [data-e2e=brdcrmb],[data-js=main-container-3]{display:none!important}article{font-size:1rem;line-height:1.364}article h1{font-size:2.182em;margin:1rem 0}}#ContentPane36 .ad.ad-5001>div:first-child{border:0 solid #e8e6e6!important;-webkit-box-sizing:content-box;box-sizing:content-box;display:inline-block;padding:4px}:lang(en) #ContentPane36 .ad.ad-5001>div:first-child:after{content:""}#ContentPane36 .ad.ad-5000>div:first-child{border:0 solid #e8e6e6!important;-webkit-box-sizing:content-box;box-sizing:content-box;display:inline-block;padding:4px}:lang(en) #ContentPane36 .ad.ad-5000>div:first-child:after{content:""}@media screen and (min-width:768px){.main-container-3 .ad-container-121,.no-js .main-container-3 .ad-container-121{min-height:282px;margin:16px 0!important}}.no-js .module-unified-right-rail{border-top:.3125rem solid #e8e6e6;font-size:1rem;margin:0 0 2.8125rem;padding:.875rem 0 0;position:relative;width:100%}@media(max-width:767px){.global-nav-search-container.global-nav__search.webmd-row{width:31.2px}}.v-modal.auth-popup-mc-modal{background:#3c4159;opacity:.9;z-index:999999!important}.menu-breadCrumb{max-width:1140px}.menu-breadCrumb .linklist-section{left:0}.breadcrumb-section{margin-left:0!important}.breadcrumb-section .webmd-breadcrumb{max-width:100%!important}.sub-container .more-about-section,.sub-container .more-about-webmd,.sub-container:not(:first-child) 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data-v-3a963452><ul class="webmd-breadcrumb" aria-label="Breadcrumb" data-metrics-module="brdcrmb" data-v-3a963452><!--[--><li class="webmd-breadcrumb__item" data-v-3a963452><span class="webmd-breadcrumb__inner" role><!--[--><a href="https://www.webmd.com/drugs/2/index" data-v-3a963452> Drugs & Medications </a><!--]--></span><i class="webmd-breadcrumb__separator"></i></li><li class="webmd-breadcrumb__item" data-v-3a963452><span class="webmd-breadcrumb__inner" role><!--[--><span class="breadcrumb-drug-name" data-v-3a963452>Duloxetine (Cymbalta, Drizalma Sprinkle)</span><!--]--></span><i class="webmd-breadcrumb__separator"></i></li><!--]--></ul><script type="application/ld+json" data-v-3a963452>{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Drugs & Medications","item":"https://www.webmd.com/drugs/2/index"},{"@type":"ListItem","position":2,"name":"Duloxetine (Cymbalta, Drizalma Sprinkle) - Uses, Side Effects, and More"}]}</script></div><header class="drug-header" aria-label="Duloxetine (Cymbalta, Drizalma Sprinkle) - Uses, Side Effects, and More" role="img" data-v-3a963452><div class="drug-name-holder" data-v-3a963452><h1 class="drug-name" lang="de" data-v-3a963452><span class="drug-name-title" data-v-3a963452>Duloxetine (Cymbalta, Drizalma Sprinkle) - Uses, Side Effects, and More</span><!----></h1><div class="auth-overlay-popup-holder" data-v-ceaaeb9c data-v-3a963452><!----><div class="bookmark-holder drug-generic-name" data-v-ceaaeb9c><!----></div></div></div><div class="drug-info-main" data-v-295799c0 data-v-3a963452><div class="drugs-reviwed" data-v-295799c0><div class="image_holder"><img src="https://img.webmd.com/vim/live/webmd/consumer_assets/site_images/articles/biographies/thomas-franko-382x382.jpg" class="author-image" /></div><div class="content_holder">Medically Reviewed by <a href="https://www.webmd.com/bio/thomas-franko">Thomas S. Franko, PharmD</a> on Oct 08, 2024 | Written by <a href="https://www.webmd.com/bio/beth-johnston">Beth Johnston, PharmD, BCPS</a></div></div><div class="drug-info-holder" data-v-295799c0><ul class="drug-info" data-v-295799c0><li class="common-brand" data-v-295799c0><strong data-v-295799c0>Common Brand Name(s):</strong> <span data-v-295799c0>Cymbalta, Drizalma Sprinkle</span></li><li class="generic-name" data-v-295799c0><strong data-v-295799c0>Common Generic Name(s):</strong> <span data-v-295799c0>duloxetine, duloxetine HCl, duloxetine hydrochloride</span></li><li data-v-295799c0><strong data-v-295799c0>Pronunciation:</strong> sim-BALL-tah , dri-ZAL-mah, doo-LOX-e-teen</li><li data-v-295799c0><strong data-v-295799c0>Drug Classes:</strong> selective serotonin and norepinephrine reuptake inhibitor (SNRI)</li><li class="availability" data-v-295799c0><strong data-v-295799c0>Availability:</strong> prescription only, generic available for some forms</li><li class="how-its-used" data-v-295799c0><strong data-v-295799c0>How is it used?</strong> capsule that is swallowed</li></ul></div></div></header><div class="auto-tabs-container-holder" data-v-3a963452><div class="auto-tabs-container-main"><div class="auto-tabs-container"><ul class="auto-tabs"><!--[--><li id="uses" data-list="uses" class="tab-1 active-tab"><a href="#">Uses</a></li><li id="sideeffects" data-list="sideeffects" class="tab-2"><a href="#">Side Effects</a></li><li id="precautions" data-list="precautions" class="tab-4"><a href="#">Warnings & Precautions</a></li><li id="interactions" data-list="interactions" class="tab-5"><a href="#">Interactions</a></li><li id="overdose" data-list="overdose" class="tab-6"><a href="#">Overdose/Missed Dose</a></li><!--]--><li><a href="https://reviews.webmd.com/drugs/drugreview-91491-duloxetine-cymbalta-drizalma-sprinkle"> Reviews (4696)</a></li></ul></div></div></div></div></div></div></div><main id="global-main" role="main" tabindex="-1" data-js="global-main" class="resp-3-col"><div class="webmd-row" style="" span="24"><div tabindex="-1" class="main-container main-container-1" data-js="main-container-1"></div><div class="webmd-col webmd-col-24 webmd-col-xs-24 webmd-col-sm-24 webmd-col-md-17 webmd-col-lg-13 webmd-col-xl-13 main-container main-container-2" style="" id="main-container" tabindex="-1" data-js="main-container-2"><div class="webmd-row pane" style="" id="ContentPane28" tabindex="-1"><div class="monograph-page" id="monograph-page" chronic-id="091e9c5e820cb8f1"><!----><div class="uses-container tab-content active-tab" id="uses-container"><!----><div class="title-bg"><span><svg width="18" height="24" viewbox="0 0 18 24" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M9.00784 18.6875C9.41429 18.6875 9.75467 18.5457 10.029 18.2622C10.3033 17.9786 10.4404 17.6343 10.4404 17.2292V15.3333H12.3988C12.8039 15.3333 13.1482 15.1911 13.4317 14.9066C13.7153 14.622 13.8571 14.2766 13.8571 13.8701C13.8571 13.4636 13.7153 13.1198 13.4317 12.8386C13.1482 12.5573 12.8039 12.4167 12.3988 12.4167H10.4404V10.5C10.4404 10.0903 10.3033 9.74826 10.029 9.47397C9.75467 9.19966 9.41429 9.0625 9.00784 9.0625C8.60138 9.0625 8.25589 9.19966 7.97137 9.47397C7.68687 9.74826 7.54462 10.0903 7.54462 10.5V12.4167H5.60709C5.202 12.4167 4.85768 12.5589 4.57412 12.8434C4.29055 13.128 4.14877 13.4734 4.14877 13.8799C4.14877 14.2864 4.29055 14.6302 4.57412 14.9114C4.85768 15.1927 5.202 15.3333 5.60709 15.3333H7.54462V17.25C7.54462 17.6597 7.68687 18.0017 7.97137 18.276C8.25589 18.5503 8.60138 18.6875 9.00784 18.6875ZM2.33624 23.25C1.76332 23.25 1.27288 23.046 0.864898 22.638C0.456919 22.2301 0.25293 21.7396 0.25293 21.1667V6.60416C0.25293 6.03124 0.456919 5.54079 0.864898 5.13281C1.27288 4.72483 1.76332 4.52084 2.33624 4.52084H15.6696C16.2425 4.52084 16.733 4.72483 17.141 5.13281C17.5489 5.54079 17.7529 6.03124 17.7529 6.60416V21.2708C17.7529 21.8472 17.5489 22.3212 17.141 22.6927C16.733 23.0642 16.2425 23.25 15.6696 23.25H2.33624ZM2.33624 21.2708H15.6696V6.60416H2.33624V21.2708ZM2.54459 2.83331C2.24946 2.83331 2.00206 2.73314 1.8024 2.53278C1.60275 2.33243 1.50293 2.08417 1.50293 1.788C1.50293 1.49183 1.60275 1.24479 1.8024 1.04688C2.00206 0.848958 2.24946 0.75 2.54459 0.75H15.4821C15.7772 0.75 16.0246 0.850177 16.2243 1.05053C16.4239 1.25089 16.5238 1.49915 16.5238 1.79531C16.5238 2.09148 16.4239 2.33852 16.2243 2.53644C16.0246 2.73435 15.7772 2.83331 15.4821 2.83331H2.54459Z" fill="#3557FF"></path></svg></span><h2 class="monograph-content-headline"> Uses </h2></div><div class="monograph-content monograph-content-holder"><div><h3><span>What is duloxetine used for?</span></h3><p dir="ltr"><span>Duloxetine is commonly used to treat the following conditions.</span></p><ul><li dir="ltr" aria-level="1"><a href="https://www.webmd.com/depression/major-depression"><span>Depression</span></a></li><li dir="ltr" aria-level="1"><a href="https://www.webmd.com/anxiety-panic/generalized-anxiety-disorder"><span>Anxiety</span></a></li><li dir="ltr" aria-level="1"><span>Nerve damage from diabetes that leads to tingling, numbness, burning, or pain, usually in the legs and feet (</span><a href="https://www.webmd.com/diabetes/diabetes-neuropathy"><span>diabetic peripheral neuropathy</span></a><span>)</span></li><li dir="ltr" aria-level="1"><span>Long-term condition that involves sleep problems, fatigue, and pain (</span><a href="https://www.webmd.com/fibromyalgia/what-is-fibromyalgia"><span>fibromyalgia</span></a><span>)</span></li><li dir="ltr" aria-level="1"><a href="https://www.webmd.com/pain-management/musculoskeletal-pain"><span>Musculoskeletal pain</span></a><span> that persists</span></li></ul><p dir="ltr"><span>Duloxetine may also be used for other conditions as determined by your healthcare provider.</span></p><h3><span>How does duloxetine work (mechanism of action)?</span></h3><p dir="ltr"><span>Duloxetine belongs to a group of medicines called serotonin-norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amount of natural chemicals or </span><a href="https://www.webmd.com/brain/neurotransmitters-what-to-know"><span>neurotransmitters</span></a><span> called </span><a href="https://www.webmd.com/depression/features/serotonin"><span>serotonin</span></a><span> and norepinephrine in the brain. </span></p><h3><span>How is duloxetine supplied (dosage forms)?</span></h3><p dir="ltr"><span>Brands and other names</span></p><ul><li dir="ltr" aria-level="1"><span>Cymbalta</span></li><li dir="ltr" aria-level="1"><span>Drizalma Sprinkle</span></li></ul><p dir="ltr"><span>Dosage forms and strengths</span></p><ul><li dir="ltr" aria-level="1"><span>20 mg oral delayed-release capsule</span></li><li dir="ltr" aria-level="1"><span>30 mg oral delayed-release capsule</span></li><li dir="ltr" aria-level="1"><span>40 mg oral delayed-release capsule</span></li><li dir="ltr" aria-level="1"><span>60 mg oral delayed-release capsule</span></li></ul><h3><span>How should I store duloxetine?</span></h3><p dir="ltr"><span>Duloxetine should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.</span></p></div></div><div class="fifth-para-ad"><span></span></div><!----></div><div class="side-effects-container center-content tab-content" id="sideeffects-container"><div class="title-bg"><span><svg width="28" height="28" viewbox="0 0 28 28" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M13.0074 2.49872C13.8566 2.49872 14.6701 2.57684 15.4479 2.73309C16.2257 2.88934 17.0972 3.15844 18.0625 3.54037L15.2083 4.82162C14.8611 4.73829 14.526 4.67753 14.2031 4.63934C13.8802 4.60114 13.4792 4.58203 13 4.58203C12.625 4.58203 12.2153 4.60634 11.7708 4.65497C11.3264 4.70357 10.9097 4.78691 10.5208 4.90497C11.8542 6.57164 13.316 7.91366 14.9062 8.93103C16.4965 9.94839 18.5764 10.3737 21.1459 10.2071H21.2917L22.1354 12.1966C19.6632 12.5091 17.4028 12.2626 15.3542 11.457C13.3056 10.6515 11.5347 9.35982 10.0417 7.58203C9.32639 9.29732 8.31771 10.7661 7.01562 11.9883C5.71354 13.2105 4.2361 14.1445 2.58331 14.7904C2.58331 17.7695 3.59547 20.2852 5.61978 22.3373C7.64409 24.3894 10.1042 25.4154 13 25.4154C15.9306 25.4154 18.4028 24.3911 20.4167 22.3425C22.4306 20.2939 23.4306 17.8459 23.4167 14.9987C23.4167 14.5959 23.3959 14.2366 23.3542 13.9206C23.3125 13.6046 23.2709 13.2973 23.2292 12.9987L24.5 10.0716C24.8472 10.9605 25.1007 11.7765 25.2604 12.5196C25.4201 13.2626 25.5 14.089 25.5 14.9987C25.5 16.7071 25.1788 18.3199 24.5365 19.8372C23.8941 21.3546 23.0121 22.6793 21.8906 23.8112C20.7691 24.9432 19.4479 25.8407 17.9271 26.5039C16.4063 27.1671 14.7639 27.4987 13 27.4987C11.2639 27.4987 9.63543 27.1741 8.11459 26.5248C6.59376 25.8755 5.2691 24.9866 4.14063 23.8581C3.01215 22.7296 2.12326 21.405 1.47397 19.8841C0.824656 18.3633 0.5 16.7348 0.5 14.9987C0.5 13.2348 0.829865 11.5907 1.48959 10.0664C2.1493 8.54212 3.04686 7.21921 4.18228 6.09769C5.3177 4.97615 6.64235 4.09594 8.15625 3.45706C9.67015 2.81817 11.2872 2.49872 13.0074 2.49872ZM9.12969 14.6654C9.59183 14.6654 9.9809 14.8249 10.2969 15.144C10.6129 15.4631 10.7708 15.8538 10.7708 16.3159C10.7708 16.7781 10.6113 17.1671 10.2922 17.4831C9.97308 17.7991 9.58246 17.9571 9.12031 17.9571C8.65817 17.9571 8.2691 17.7975 7.95312 17.4784C7.63715 17.1593 7.47916 16.7687 7.47916 16.3065C7.47916 15.8444 7.63871 15.4553 7.95781 15.1393C8.27692 14.8234 8.66754 14.6654 9.12969 14.6654ZM16.9005 14.6654C17.3627 14.6654 17.7517 14.8249 18.0677 15.144C18.3837 15.4631 18.5417 15.8538 18.5417 16.3159C18.5417 16.7781 18.3821 17.1671 18.063 17.4831C17.7439 17.7991 17.3533 17.9571 16.8912 17.9571C16.429 17.9571 16.0399 17.7975 15.724 17.4784C15.408 17.1593 15.25 16.7687 15.25 16.3065C15.25 15.8444 15.4096 15.4553 15.7287 15.1393C16.0478 14.8234 16.4384 14.6654 16.9005 14.6654ZM22.875 0.769531L24.25 3.89453L27.3125 5.20703L24.25 6.54038L22.875 9.66537L21.4792 6.54038L18.4167 5.20703L21.4792 3.89453L22.875 0.769531ZM2.96872 12.28C3.98955 11.8286 5.05901 11.0057 6.17709 9.81122C7.29516 8.61678 8.10071 7.19664 8.59375 5.55078C7.03125 6.29384 5.80902 7.24176 4.92706 8.39453C4.04513 9.54732 3.39234 10.8425 2.96872 12.28Z" fill="#3557FF"></path></svg></span><h2 class="monograph-content-headline"> Side Effects </h2></div><!----><div class="monograph-content"><h3><span>What are the most common side effects of duloxetine?</span></h3><p dir="ltr"><span>The most common side effects of duloxetine are listed below. Tell your healthcare provider if you have any of these side effects that bother you.</span></p><ul><li dir="ltr" aria-level="1"><span>Nausea</span></li><li dir="ltr" aria-level="1"><span>Dry mouth</span></li><li dir="ltr" aria-level="1"><span>Dizziness</span></li><li dir="ltr" aria-level="1"><span>Drowsiness or tiredness</span></li><li dir="ltr" aria-level="1"><span>Constipation</span></li><li dir="ltr" aria-level="1"><span>Feeling less hungry </span></li><li dir="ltr" aria-level="1"><span>Sweating</span></li><li dir="ltr" aria-level="1"><span>Slowed growth (see below)</span></li><li dir="ltr" aria-level="1"><span>Diarrhea (in children)</span></li></ul><p dir="ltr"><span>There may be other side effects of duloxetine that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at </span><a href="https://www.fda.gov/medwatch"><span>www.fda.gov/medwatch</span></a><span> or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at </span><a href="https://www.health.gc.ca/medeffect"><span>www.health.gc.ca/medeffect</span></a><span> or by calling 866-234-2345.</span></p><h3><span>What are the serious side effects of duloxetine?</span></h3><p dir="ltr"><span>While less common, the most serious side effects of duloxetine are described below, along with what to do if they happen.</span></p><p dir="ltr"><span><strong>Severe Allergic Reactions.</strong> Duloxetine may cause </span><a href="https://www.webmd.com/allergies/allergic-reaction-causes"><span>allergic reactions</span></a><span>, which can be serious. Stop taking duloxetine and get help right away if you have any of the following symptoms of a serious allergic reaction.</span></p><ul><li dir="ltr" aria-level="1"><span>Breathing problems or wheezing</span></li><li dir="ltr" aria-level="1"><span>Racing heart</span></li><li dir="ltr" aria-level="1"><span>Fever or general ill feeling</span></li><li dir="ltr" aria-level="1"><span>Swollen </span><a href="https://www.webmd.com/a-to-z-guides/what-are-lymph-nodes"><span>lymph nodes</span></a></li><li dir="ltr" aria-level="1"><span>Swelling of the face, lips, mouth, tongue, or throat</span></li><li dir="ltr" aria-level="1"><span>Trouble swallowing or throat tightness</span></li><li dir="ltr" aria-level="1"><span>Itching, skin rash, or pale red bumps on the skin called </span><a href="https://www.webmd.com/skin-problems-and-treatments/hives-urticaria-angioedema"><span>hives</span></a></li><li dir="ltr" aria-level="1"><span>Nausea or vomiting</span></li><li dir="ltr" aria-level="1"><span>Dizziness, feeling lightheaded, or fainting</span></li><li dir="ltr" aria-level="1"><span>Stomach cramps</span></li><li dir="ltr" aria-level="1"><span>Joint pain</span></li></ul><p dir="ltr"><span><strong>Suicidal Thoughts or Actions.</strong> Duloxetine or other antidepressants may increase the risk of suicidal thoughts or actions in a small number of children, teenagers, or young adults in the first few months of taking the medicine or when the dose is changed. Depression or other serious mental health conditions are the most important causes of suicidal thoughts or actions. If you or your child is about to harm themselves, call 911 or call or text 988, the Suicide & Crisis Lifeline. Call your healthcare provider right away if you have any of the following symptoms.</span></p><ul><li dir="ltr" aria-level="1"><span>New or increased thoughts of suicide or death</span></li><li dir="ltr" aria-level="1"><span>Suicide attempt</span></li><li dir="ltr" aria-level="1"><span>New or increased feelings of anxiety, depression, or other unusual changes in your mood or behavior</span></li></ul><p dir="ltr"><span><strong>Liver Damage.</strong> Liver damage, also called </span><a href="https://www.webmd.com/hepatitis/toxic-liver-disease"><span>hepatotoxicity</span></a><span>, can happen when taking duloxetine. Stop taking duloxetine and call your healthcare provider right away if you have any of the following symptoms of liver damage.</span></p><ul><li dir="ltr" aria-level="1"><span>Nausea or vomiting</span></li><li dir="ltr" aria-level="1"><span>Stomach or belly pain</span></li><li dir="ltr" aria-level="1"><span>Fever</span></li><li dir="ltr" aria-level="1"><span>Weakness or unusual tiredness</span></li><li dir="ltr" aria-level="1"><span>Itching</span></li><li dir="ltr" aria-level="1"><span>Loss of appetite</span></li><li dir="ltr" aria-level="1"><span>Light-colored poop</span></li><li dir="ltr" aria-level="1"><span>Dark-colored urine (pee)</span></li><li dir="ltr" aria-level="1"><span>Your skin or the whites of your eyes turning yellowish in color (also called </span><a href="https://www.webmd.com/hepatitis/jaundice-why-happens-adults"><span>jaundice</span></a><span>)</span></li></ul><p dir="ltr"><span><strong>Low Blood Pressure Upon Standing (</strong></span><a href="https://www.webmd.com/heart/what-is-orthostatic-hypotension-dizzy-standing"><span><strong>Orthostatic Hypotension</strong></span></a><span><strong>) and Falls. </strong>Duloxetine may cause a sudden drop in blood pressure when standing up from a seated or lying position. This can sometimes lead to fainting or falls. Falls can lead to serious problems including fractures. To help prevent this, be careful not to get up too quickly. If you feel dizzy, sit or lie down right away until the dizziness stops, then take your time getting up again. Tell your healthcare provider right away if you have any of the following symptoms of orthostatic hypotension.</span></p><ul><li dir="ltr" aria-level="1"><span>Dizziness, feeling lightheaded, or fainting upon standing</span></li><li dir="ltr" aria-level="1"><span>Blurred vision</span></li><li dir="ltr" aria-level="1"><span>Confusion</span></li><li dir="ltr" aria-level="1"><span>Feeling weak</span></li></ul><p dir="ltr"><span><strong>Serotonin Syndrome. </strong></span><a href="https://www.webmd.com/brain/serotonin-syndrome-causes-symptoms-treatments"><span>Serotonin syndrome</span></a><span> is when there is too much of a substance called serotonin in your body. Duloxetine can cause serotonin syndrome when it is taken alone or with other medicines that affect serotonin. This condition can be life-threatening. Get emergency help if you have any of the following symptoms of serotonin syndrome.</span></p><ul><li dir="ltr" aria-level="1"><span>Sweating, fever, or flushing</span></li><li dir="ltr" aria-level="1"><span>Confusion</span></li><li dir="ltr" aria-level="1"><span>Feeling agitated or restless</span></li><li dir="ltr" aria-level="1"><span>Seeing or hearing unusual things</span></li><li dir="ltr" aria-level="1"><span>Dizziness</span></li><li dir="ltr" aria-level="1"><span>Fast or racing heartbeat</span></li><li dir="ltr" aria-level="1"><span>Nausea, vomiting, or diarrhea</span></li><li dir="ltr" aria-level="1"><span>Muscle twitching, stiffness, or tremor</span></li><li dir="ltr" aria-level="1"><span>Seizures</span></li></ul><p dir="ltr"><span><strong>Increased Blood Pressure (</strong></span><a href="https://www.webmd.com/hypertension-high-blood-pressure/high-blood-pressure"><span><strong>Hypertension</strong></span></a><span><strong>). </strong>Duloxetine may increase your blood pressure or make it worse if you have a history of high blood pressure. Call your healthcare provider if your blood pressure increases while taking this medicine.</span></p><p dir="ltr"><span>If you measure your blood pressure and the top number (systolic) is 180 mm Hg or higher or the bottom number (diastolic) is 120 mm Hg or higher, get medical attention right away. Increases in blood pressure may not be noticeable but look out for any of the following symptoms of severely high blood pressure.</span></p><ul><li dir="ltr" aria-level="1"><span>Sudden severe headache</span></li><li dir="ltr" aria-level="1"><span>Chest pain</span></li><li dir="ltr" aria-level="1"><span>Dizziness or confusion</span></li><li dir="ltr" aria-level="1"><span>Trouble breathing</span></li><li dir="ltr" aria-level="1"><span>Nausea/vomiting</span></li><li dir="ltr" aria-level="1"><span>Blurry or other changes to vision</span></li><li dir="ltr" aria-level="1"><span>Anxiety</span></li><li dir="ltr" aria-level="1"><span>Buzzing in the ears</span></li><li dir="ltr" aria-level="1"><span>Nosebleed</span></li><li dir="ltr" aria-level="1"><span>Feeling of skipped heartbeats</span></li></ul><p dir="ltr"><span><strong>Abnormal Bleeding. </strong>People taking duloxetine or other antidepressants may have an increased risk of bleeding or bruising. You may be at higher risk if you are also taking aspirin, a nonsteroidal anti-inflammatory drug (NSAID), like ibuprofen or naproxen, or a blood thinner such as warfarin, apixaban (Eliquis), or rivaroxaban (Xarelto). Tell your healthcare provider if you notice any changes in how easily you bruise or bleed.</span></p><p dir="ltr"><span><strong>Extremely Elevated Mood (Mania).</strong> People with </span><a href="https://www.webmd.com/bipolar-disorder/mental-health-bipolar-disorder"><span>bipolar disorder</span></a><span> can have severe high and low moods. The first symptom of bipolar disorder may be depression. People with bipolar disorder who take an antidepressant, such as duloxetine, may have a higher risk of having mania or a manic episode. Call your healthcare provider right away if you have any of the following symptoms of a manic episode.</span></p><ul><li dir="ltr" aria-level="1"><span>Very increased energy</span></li><li dir="ltr" aria-level="1"><span>Significant trouble sleeping</span></li><li dir="ltr" aria-level="1"><span>Racing, fast-paced thoughts</span></li><li dir="ltr" aria-level="1"><span>Reckless behavior</span></li><li dir="ltr" aria-level="1"><span>Unusually grand ideas</span></li><li dir="ltr" aria-level="1"><span>Excessive happiness or irritability</span></li><li dir="ltr" aria-level="1"><span>Talking more or faster than usual</span></li></ul><p dir="ltr"><span><strong>Severe Skin Reactions. </strong>duloxetine can cause severe skin reactions called </span><a href="https://www.webmd.com/skin-problems-and-treatments/stevens-johnson-syndrome"><span>Stevens-Johnson Syndrome (SJS)</span></a><span> and </span><a href="https://www.webmd.com/skin-problems-and-treatments/what-is-toxic-epidermal-necrolysis"><span>Toxic Epidermal Necrolysis (TEN)</span></a><span> that can lead to death if not treated. If you develop a rash, stop duloxetine and call your healthcare provider right away. Get emergency help right away if you have any of the following symptoms of SJS or TEN.</span></p><ul><li dir="ltr" aria-level="1"><span>Painful red or purple skin that looks burned and peels off</span></li><li dir="ltr" aria-level="1"><span>Flat red rash or blisters on your skin, mouth, nose, and genitals</span></li><li dir="ltr" aria-level="1"><span>Red, painful, watery eyes</span></li></ul><p dir="ltr"><span><strong>Glaucoma. </strong>Duloxetine may increase pressure inside the eye and cause or worsen narrow-angle</span><a href="https://www.webmd.com/eye-health/glaucoma-eyes"><span> glaucoma</span></a><span>, which can lead to blindness. Tell your healthcare provider right away if you have any of the following symptoms of glaucoma.</span></p><ul><li dir="ltr" aria-level="1"><span>Loss of vision</span></li><li dir="ltr" aria-level="1"><span>Eye pain or redness</span></li><li dir="ltr" aria-level="1"><span>Severe headache or vomiting</span></li><li dir="ltr" aria-level="1"><span>Seeing bright, colorful circles around lights (vision halos)</span></li></ul><p dir="ltr"><span><strong>Seizures. </strong>Some people who have taken duloxetine have reported having </span><a href="https://www.webmd.com/epilepsy/understanding-seizures-basics"><span>seizures</span></a><span>. There are many different types of seizures and some of them are not easy to recognize. Stop taking duloxetine and call your healthcare provider if you have any of the following signs that a seizure is happening or could happen.</span></p><ul><li dir="ltr" aria-level="1"><span>Muscle twitching, jerking, spasms, tremors, or other uncontrolled movements</span></li><li dir="ltr" aria-level="1"><span>Stiffening of your arms and legs</span></li><li dir="ltr" aria-level="1"><span>Feeling anxious, nervous, confused, or a sense of dread</span></li><li dir="ltr" aria-level="1"><span>Feeling dizzy or lightheaded</span></li><li dir="ltr" aria-level="1"><span>Falling or losing consciousness</span></li></ul><p dir="ltr"><span><strong>Low Sodium Level (</strong></span><a href="https://www.webmd.com/a-to-z-guides/what-is-hyponatremia"><span><strong>Hyponatremia</strong></span></a><span><strong>). </strong>Duloxetine may cause low sodium levels. Stop taking duloxetine and call your healthcare provider if you have any of the following symptoms of a low sodium level.</span></p><ul><li dir="ltr" aria-level="1"><span>Headache</span></li><li dir="ltr" aria-level="1"><span>Drowsiness</span></li><li dir="ltr" aria-level="1"><span>Muscle weakness or cramps</span></li><li dir="ltr" aria-level="1"><span>Nausea, vomiting, or loss of appetite</span></li><li dir="ltr" aria-level="1"><span>Tiredness or sleepiness</span></li><li dir="ltr" aria-level="1"><span>Dizziness</span></li><li dir="ltr" aria-level="1"><span>Weight gain</span></li><li dir="ltr" aria-level="1"><span>Restlessness or irritability</span></li><li dir="ltr" aria-level="1"><span>Change in your mental condition such as </span><a href="https://www.webmd.com/schizophrenia/what-are-hallucinations"><span>hallucinations</span></a><span>, confusion, decreased awareness, or alertness</span></li><li dir="ltr" aria-level="1"><span>Seizures</span></li></ul><p dir="ltr"><span><strong>Inability to Empty Bladder (Urinary Retention).</strong> Duloxetine might make it harder to empty your bladder, especially if you already have a blockage. Call your healthcare provider right away if you are having trouble peeing or cannot empty your bladder.</span></p><p dir="ltr"><span><strong>Sexual Problems. </strong>Taking duloxetine or another selective serotonin reuptake inhibitor (SSRI) may cause sexual problems. Tell your healthcare provider if you have any of the following sexual problems. </span></p><ul><li dir="ltr" aria-level="1"><span>Decreased sex drive</span></li><li dir="ltr" aria-level="1"><span>Delayed ejaculation or unable to have an ejaculation</span></li><li dir="ltr" aria-level="1"><span>Problems getting or keeping an erection</span></li><li dir="ltr" aria-level="1"><span>Delayed orgasm or unable to have an orgasm</span></li></ul></div><div class="fifth-para-ad mobile-ads-holder ads-loaded"><span></span></div></div><div class="precautions-container tab-content" id="precautions-container"><div class="title-bg"><span><svg width="26" height="24" viewbox="0 0 26 24" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M1.05067 23.2513C0.849293 23.2513 0.671157 23.2036 0.516262 23.1081C0.361366 23.0126 0.240897 22.8867 0.154855 22.7305C0.0622511 22.5763 0.0113136 22.4093 0.00204276 22.2294C-0.00720724 22.0496 0.0437302 21.8694 0.154855 21.6888L12.0924 1.06381C12.2035 0.88325 12.3371 0.751302 12.4934 0.667969C12.6496 0.584635 12.818 0.542969 12.9986 0.542969C13.1792 0.542969 13.3476 0.584635 13.5038 0.667969C13.6601 0.751302 13.7938 0.88325 13.9049 1.06381L25.8424 21.6888C25.9535 21.8694 26.0044 22.0496 25.9951 22.2294C25.9859 22.4093 25.935 22.5763 25.8424 22.7305C25.7563 22.8867 25.6358 23.0126 25.4809 23.1081C25.3261 23.2036 25.1479 23.2513 24.9465 23.2513H1.05067ZM2.85276 21.168H23.1444L12.9986 3.66797L2.85276 21.168ZM13.0856 19.5638C13.3818 19.5638 13.6288 19.4636 13.8267 19.2633C14.0246 19.0629 14.1236 18.8147 14.1236 18.5185C14.1236 18.2223 14.0234 17.9753 13.8231 17.7774C13.6227 17.5795 13.3745 17.4805 13.0783 17.4805C12.7821 17.4805 12.5351 17.5807 12.3372 17.781C12.1393 17.9814 12.0403 18.2296 12.0403 18.5258C12.0403 18.822 12.1405 19.069 12.3408 19.2669C12.5412 19.4649 12.7894 19.5638 13.0856 19.5638ZM13.0856 16.0013C13.3818 16.0013 13.6288 15.9015 13.8267 15.7018C14.0246 15.5022 14.1236 15.2548 14.1236 14.9597V10.293C14.1236 9.99782 14.0234 9.75043 13.8231 9.55078C13.6227 9.35114 13.3745 9.25131 13.0783 9.25131C12.7821 9.25131 12.5351 9.35114 12.3372 9.55078C12.1393 9.75043 12.0403 9.99782 12.0403 10.293V14.9597C12.0403 15.2548 12.1405 15.5022 12.3408 15.7018C12.5412 15.9015 12.7894 16.0013 13.0856 16.0013Z" fill="#3557FF"></path></svg></span><h2 class="monograph-content-headline"> Warnings & Precautions </h2></div><!----><div class="monograph-content"><div><h3><span>Who should not use duloxetine?</span></h3><p dir="ltr"><span><strong>Allergies to Ingredients.</strong> People who are allergic to any of the following should not take duloxetine.</span></p><ul><li dir="ltr" aria-level="1"><span>Duloxetine</span></li><li dir="ltr" aria-level="1"><span>Cymbalta</span></li><li dir="ltr" aria-level="1"><span>Drizalma Sprinkle</span></li><li dir="ltr" aria-level="1"><span>Any of the ingredients in the specific product dispensed</span></li></ul><p dir="ltr"><span>Your pharmacist can tell you all of the ingredients in the specific duloxetine products they stock.</span></p><p dir="ltr"><span><strong>Drug Interactions. </strong>Duloxetine should not be taken while you are using certain other medicines. Before taking duloxetine, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are taking. See the Interactions section for more details.</span></p><p dir="ltr"><span><strong>Kidney Problems.</strong> Duloxetine should not be used if your kidneys are not working as well as they should be. If there is a concern about the health of your kidneys, your healthcare provider may do tests to determine if they are working well enough to take this medicine.</span></p><p dir="ltr"><span><strong>Liver Problems. </strong>Duloxetine should not be used if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine.</span></p><h3><span>What should I know about duloxetine before using it?</span></h3><p dir="ltr"><span>Do not take duloxetine unless it has been prescribed to you by a healthcare provider. Take it as prescribed.</span></p><p dir="ltr"><span>Do not share duloxetine with other people, even if they have the same condition as you. It may harm them.</span></p><p dir="ltr"><span>Keep duloxetine out of the reach of children.</span></p><p dir="ltr"><span>Do not chew or crush duloxetine delayed-release capsules. They should be swallowed whole. Some duloxetine delayed-release capsules can be opened up to be given through a feeding tube or mixed with applesauce for people who have trouble swallowing capsules. If you have a feeding tube or trouble swallowing capsules, talk to your pharmacist for specific directions on how to do this.</span></p><p dir="ltr"><span>Duloxetine can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how duloxetine affects you.</span></p><p dir="ltr"><span>Duloxetine can make you feel less hungry, which may slow down growth in children and adolescents who are still growing. Talk with the healthcare provider if you have any concerns about how your child is growing.</span></p><p dir="ltr"><span>Do not stop taking duloxetine without talking to your healthcare provider. Stopping too quickly may cause serious side effects. Call your healthcare provider right away if you have any of the following symptoms.</span></p><ul><li dir="ltr" aria-level="1"><span>Anxiety, irritability, or high or low mood</span></li><li dir="ltr" aria-level="1"><span>Feeling restless </span></li><li dir="ltr" aria-level="1"><span>Changes in sleep habits</span></li><li dir="ltr" aria-level="1"><span>Headache</span></li><li dir="ltr" aria-level="1"><span>Sweating or shaking</span></li><li dir="ltr" aria-level="1"><span>Nausea or diarrhea</span></li><li dir="ltr" aria-level="1"><span>Dizziness</span></li><li dir="ltr" aria-level="1"><span>Electric-shock like feelings</span></li><li dir="ltr" aria-level="1"><span>Confusion</span></li></ul><p dir="ltr"><span>If you have diabetes, duloxetine may increase your blood sugar levels. Talk with your healthcare provider about how to maintain healthy blood sugar levels.</span></p><p dir="ltr"><span>People who are 65 or older can be at greater risk for some side effects from duloxetine. Talk to your healthcare provider about your risks if you are in this age group.</span></p><h3><span>What should I tell my healthcare provider before using duloxetine?</span></h3><p dir="ltr"><span>Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are taking. This will help them determine if duloxetine is right for you.</span></p><p dir="ltr"><span>In particular, make sure that you discuss any of the following.</span></p><p dir="ltr"><span><strong>Current and Past Health Conditions. </strong>Tell your healthcare provider if you have any of the following.</span></p><ul><li dir="ltr" aria-level="1"><span>Heart problems</span></li><li dir="ltr" aria-level="1"><span>High blood pressure</span></li><li dir="ltr" aria-level="1"><span>Diabetes</span></li><li dir="ltr" aria-level="1"><span>Glaucoma</span></li><li dir="ltr" aria-level="1"><span>Seizures</span></li><li dir="ltr" aria-level="1"><span>Mental health conditions such as bipolar disorder, mania</span></li><li dir="ltr" aria-level="1"><span>Low blood sodium levels</span></li><li dir="ltr" aria-level="1"><span>Slow emptying of your stomach</span></li><li dir="ltr" aria-level="1"><span>Bleeding problems</span></li><li dir="ltr" aria-level="1"><span>Drink alcohol, especially in large amounts</span></li><li dir="ltr" aria-level="1"><span>Trouble peeing or emptying your bladder</span></li></ul><p dir="ltr"><span><strong>Pregnancy. </strong>Taking duloxetine later in pregnancy may lead to an increased risk of certain problems in your unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take duloxetine while you are pregnant or trying to become pregnant. If you become pregnant while taking duloxetine, you can register for the National Pregnancy Registry for Antidepressants by calling 844-405-6185 or at www.womensmentalhealth.org/research/pregnancyregistry/antidepressants. This registry collects safety information about the use of antidepressant medicines during pregnancy.</span></p><p dir="ltr"><span><strong>Breastfeeding. </strong>Duloxetine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take duloxetine while breastfeeding. If you breastfeed while taking duloxetine, call your healthcare provider right away if your baby becomes sleepy, or is not feeding well or gaining weight.</span></p></div></div><div class="fifth-para-ad mobile-ads-holder ads-loaded"><span></span></div></div><div class="interactions-container center-content tab-content" id="interactions-container"><div class="title-bg"><span><svg width="26" height="28" viewbox="0 0 26 28" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M18.5208 25.1042L20.1042 23.5L17.5 20.8958L15.8958 22.4792C15.5208 22.8542 15.3368 23.2917 15.3438 23.7917C15.3507 24.2917 15.5347 24.7292 15.8958 25.1042C16.2708 25.4653 16.7083 25.6493 17.2083 25.6562C17.7083 25.6632 18.1458 25.4792 18.5208 25.1042ZM21.5417 22.0625L23.1458 20.4792C23.5208 20.1042 23.7049 19.6667 23.6979 19.1667C23.691 18.6667 23.5 18.2292 23.125 17.8542C22.75 17.4792 22.3175 17.2917 21.8275 17.2917C21.3375 17.2917 20.9019 17.4792 20.5208 17.8542L18.9375 19.4583L21.5417 22.0625ZM19.9896 26.5729C19.2188 27.3437 18.2917 27.7291 17.2083 27.7291C16.125 27.7291 15.1979 27.3437 14.4271 26.5729C13.6563 25.8021 13.2708 24.875 13.2708 23.7917C13.2708 22.7083 13.6563 21.7812 14.4271 21.0104L19.0521 16.3854C19.8229 15.6146 20.75 15.2292 21.8333 15.2292C22.9167 15.2292 23.8438 15.6146 24.6146 16.3854C25.3854 17.1562 25.7708 18.0833 25.7708 19.1667C25.7708 20.25 25.3854 21.1771 24.6146 21.9479L19.9896 26.5729ZM2.83331 25.25C2.2604 25.25 1.76995 25.046 1.36197 24.638C0.953989 24.2301 0.75 23.7396 0.75 23.1667V4.83331C0.75 4.2604 0.953989 3.76995 1.36197 3.36197C1.76995 2.95399 2.2604 2.75 2.83331 2.75H8.85419C9.0139 2.0139 9.38716 1.4132 9.97397 0.947906C10.5608 0.482635 11.2361 0.25 12 0.25C12.7639 0.25 13.4392 0.482635 14.026 0.947906C14.6128 1.4132 14.9861 2.0139 15.1458 2.75H21.1667C21.7396 2.75 22.2301 2.95399 22.638 3.36197C23.046 3.76995 23.25 4.2604 23.25 4.83331V13.3021C22.9028 13.2118 22.5556 13.1597 22.2083 13.1458C21.8611 13.1319 21.5139 13.1493 21.1667 13.1979V4.83331H2.83331V23.1667H11.2188C11.184 23.5139 11.1771 23.8611 11.1979 24.2083C11.2188 24.5556 11.2743 24.9028 11.3646 25.25H2.83331ZM12 4.16666C12.2847 4.16666 12.5295 4.06423 12.7344 3.85938C12.9392 3.6545 13.0417 3.40971 13.0417 3.125C13.0417 2.84027 12.9392 2.59548 12.7344 2.39062C12.5295 2.18575 12.2847 2.08331 12 2.08331C11.7153 2.08331 11.4705 2.18575 11.2656 2.39062C11.0608 2.59548 10.9583 2.84027 10.9583 3.125C10.9583 3.40971 11.0608 3.6545 11.2656 3.85938C11.4705 4.06423 11.7153 4.16666 12 4.16666ZM5.75 9.83331V7.75H18.25V9.83331H5.75ZM5.75 15.0417V12.9583H18.25V14.3333C18.1528 14.3958 18.0538 14.4705 17.9531 14.5573C17.8524 14.6441 17.7535 14.7361 17.6562 14.8333L17.4479 15.0417H5.75ZM5.75 20.25V18.1667H14.3229L12.9375 19.5521C12.8125 19.6771 12.7031 19.7934 12.6094 19.901C12.5156 20.0087 12.4236 20.125 12.3333 20.25H5.75Z" fill="#3557FF"></path></svg></span><h2 class="monograph-content-headline"> Interactions </h2></div><!----><div><div class="monograph-content"><h3><span>Does duloxetine interact with foods or drinks?</span></h3><p dir="ltr"><span>There are no known interactions between duloxetine and foods or drinks.</span></p><p dir="ltr"><span>There are no known interactions between duloxetine and alcohol. However, the risk of liver damage may be increased if you drink alcohol, especially large amounts, while taking duloxetine.</span></p><h3><span>Does duloxetine interact with other medicines (drug interactions)?</span></h3><p dir="ltr"><span>Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are taking.</span></p><p dir="ltr"><span>In particular, make sure that you discuss if you are taking any of the following before taking duloxetine.</span></p><ul><li dir="ltr" aria-level="1"><span>A monoamine oxidase inhibitor (MAOI) within the past 2 weeks, which is a medicine usually used for depression or Parkinson’s disease</span></li><li dir="ltr" aria-level="1"><span>Linezolid, which is a medicine used for bacterial infections</span></li><li dir="ltr" aria-level="1"><span>Thioridazine, which is a medicine for certain mental health conditions</span></li><li dir="ltr" aria-level="1"><span>A type of medicine called a triptan, such as sumatriptan (Imitrex and others), eletriptan (Relpax), and others, which is commonly used to treat migraines</span></li><li dir="ltr" aria-level="1"><span>A tricyclic antidepressant, such as amitriptyline, nortriptyline, or protriptyline, even if it is not used for depression</span></li><li dir="ltr" aria-level="1"><span>An opioid, such as oxycodone, morphine, codeine, or fentanyl, which is a medicine used for certain types of pain</span></li><li dir="ltr" aria-level="1"><span>Buspirone, which is a medicine for anxiety</span></li><li dir="ltr" aria-level="1"><span>A stimulant, such as methylphenidate, lisdexamfetamine, or amphetamine, which is a medicine commonly used to treat attention deficit hyperactivity disorder (ADHD)</span></li><li dir="ltr" aria-level="1"><span>St. John’s wort, which is a supplement that may be used to treat depression</span></li><li dir="ltr" aria-level="1"><span>Tryptophan, which is a supplement that may be used to help the body make proteins and certain brain-signaling chemicals</span></li><li dir="ltr" aria-level="1"><span>A selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI), which is a medicine commonly used for anxiety and depression</span></li><li dir="ltr" aria-level="1"><span>Lithium, which is a medicine for certain mental health conditions</span></li><li dir="ltr" aria-level="1"><span>A proton pump inhibitor (PPI), such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (Aciphex)</span></li><li dir="ltr" aria-level="1"><span>Ciprofloxacin, which is a medicine used for bacterial infections</span></li><li dir="ltr" aria-level="1"><span>A medicine used to control your heart rate or rhythm (antiarrhythmic)</span></li><li dir="ltr" aria-level="1"><span>Aspirin or a nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen, naproxen, and others, which is in many prescription and OTC products for pain, swelling, and fever</span></li><li dir="ltr" aria-level="1"><span>Warfarin, which is a blood thinner</span></li><li dir="ltr" aria-level="1"><span>Theophylline (Theo-24, Elixophyllin), which is a medicine for asthma or certain other breathing problems</span></li><li dir="ltr" aria-level="1"><span>Any other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, and medicines for anxiety</span></li><li dir="ltr" aria-level="1"><span>Any other medicine that contains duloxetine</span></li></ul><p dir="ltr"><span>Many other medicines may alter the blood levels of duloxetine, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.</span></p><p dir="ltr"><span>This may not be a complete list of medicines that can interact with duloxetine. Always check with your healthcare provider.</span></p></div></div><div class="check-int-panel"><div class="message-container"><span class="icon"><svg width="40" height="40" viewBox="0 0 40 40" fill="none" xmlns="https://www.w3.org/2000/svg"><mask id="mask0_1_17" style="mask-type:alpha;" maskUnits="userSpaceOnUse" x="0" y="0" width="40" height="40"><rect width="40" height="40" fill="#D9D9D9"></rect></mask><g mask="url(#mask0_1_17)"><path d="M28.6945 34.8056L30.8056 32.6667L27.3333 29.1944L25.1944 31.3055C24.6944 31.8055 24.4491 32.3889 24.4583 33.0555C24.4676 33.7222 24.7129 34.3055 25.1944 34.8056C25.6944 35.287 26.2778 35.5324 26.9445 35.5417C27.6111 35.5509 28.1945 35.3056 28.6945 34.8056ZM32.7222 30.75L34.8611 28.6389C35.3611 28.1389 35.6065 27.5555 35.5972 26.8889C35.588 26.2222 35.3333 25.6389 34.8333 25.1389C34.3333 24.6389 33.7567 24.3889 33.1033 24.3889C32.45 24.3889 31.8693 24.6389 31.3611 25.1389L29.25 27.2778L32.7222 30.75ZM30.6528 36.7639C29.625 37.7916 28.3889 38.3054 26.9445 38.3054C25.5 38.3054 24.2639 37.7916 23.2361 36.7639C22.2083 35.7361 21.6945 34.5 21.6945 33.0555C21.6945 31.6111 22.2083 30.375 23.2361 29.3472L29.4028 23.1805C30.4306 22.1528 31.6667 21.6389 33.1111 21.6389C34.5556 21.6389 35.7917 22.1528 36.8195 23.1805C37.8472 24.2083 38.3611 25.4444 38.3611 26.8889C38.3611 28.3333 37.8472 29.5694 36.8195 30.5972L30.6528 36.7639ZM7.77775 35C7.01386 35 6.35993 34.728 5.81596 34.184C5.27199 33.6401 5 32.9861 5 32.2222V7.77774C5 7.01385 5.27199 6.35992 5.81596 5.81595C6.35993 5.27198 7.01386 4.99999 7.77775 4.99999H15.8056C16.0185 4.01852 16.5162 3.21759 17.2986 2.5972C18.081 1.97684 18.9815 1.66666 20 1.66666C21.0185 1.66666 21.919 1.97684 22.7014 2.5972C23.4838 3.21759 23.9815 4.01852 24.1944 4.99999H32.2222C32.9861 4.99999 33.6401 5.27198 34.184 5.81595C34.728 6.35992 35 7.01385 35 7.77774V19.0694C34.537 18.9491 34.0741 18.8796 33.6111 18.8611C33.1482 18.8426 32.6852 18.8657 32.2222 18.9306V7.77774H7.77775V32.2222H18.9583C18.9121 32.6852 18.9028 33.1481 18.9306 33.6111C18.9584 34.0741 19.0324 34.537 19.1528 35H7.77775ZM20 6.88887C20.3796 6.88887 20.706 6.7523 20.9792 6.47916C21.2523 6.20599 21.3889 5.8796 21.3889 5.49999C21.3889 5.12035 21.2523 4.79396 20.9792 4.52082C20.706 4.24766 20.3796 4.11107 20 4.11107C19.6204 4.11107 19.294 4.24766 19.0208 4.52082C18.7477 4.79396 18.6111 5.12035 18.6111 5.49999C18.6111 5.8796 18.7477 6.20599 19.0208 6.47916C19.294 6.7523 19.6204 6.88887 20 6.88887ZM11.6667 14.4444V11.6667H28.3333V14.4444H11.6667ZM11.6667 21.3889V18.6111H28.3333V20.4444C28.2037 20.5278 28.0718 20.6273 27.9375 20.7431C27.8032 20.8588 27.6713 20.9815 27.5417 21.1111L27.2639 21.3889H11.6667ZM11.6667 28.3333V25.5556H23.0972L21.25 27.4028C21.0833 27.5694 20.9375 27.7245 20.8125 27.868C20.6875 28.0116 20.5648 28.1667 20.4445 28.3333H11.6667Z" fill="#3557FF"></path></g></svg></span><p class="typeahead-title"> Does interact with other drugs you are taking? </p><p class="optional-text"> Enter your medication into the WebMD interaction checker </p></div><div class="typeahead-container"><div class="drug-panel"><div class="webmd-typeahead typeahead-custom-width" aria-haspopup="listbox" role="combobox" aria-expanded="false" aria-owns="webmd-typeahead" matchwidth="false"><div class="webmd-input__div webmd-input-noLabel webmd-input--medium webmd-input--prefix"><!--[--><!--v-if--><!--v-if--><input class="webmd-input__inner" type="text" autocomplete="off" value placeholder="Enter drug name" valuekey="value" matchwidth="false" triggeronfocus="false" triggeratlength="0" selectwhenunmatched="false" debounce="300" placement="bottom-start" hideloading="false" popperappendtobody="true" aria-label="Enter search terms"><span class="webmd-input__prefix"><!--[--><!--]--><i class="webmd-input__icon webmd-icon-search webmd-input__icon"></i></span><!--v-if--><!--v-if--><!--]--></div><div class="webmd-autocomplete-suggestion webmd-popper" style="display:none;" role="region" size="medium"><div class="webmd-scrollbar"><div style="" class="webmd-autocomplete-suggestion__wrap webmd-scrollbar__wrap webmd-scrollbar__wrap--hidden-default"><!--[--><ul class="webmd-scrollbar__view webmd-autocomplete-suggestion__list" style=""><!--[--><!--]--></ul><!--]--></div><div class="webmd-scrollbar__bar is-horizontal"><div class="webmd-scrollbar__thumb" style="width:0;transform:translateX(0%);ms-transform:translateX(0%);webkit-transform:translateX(0%);"></div></div><div class="webmd-scrollbar__bar is-vertical"><div class="webmd-scrollbar__thumb" style="height:0;transform:translateY(0%);ms-transform:translateY(0%);webkit-transform:translateY(0%);"></div></div></div></div></div><!----></div><div class="button-element"><button class="webmd-button webmd-button--primary webmd-button--medium is-disabled" disabled type="button"><!--v-if--><!--v-if--><span><!--[--> Check Interactions <!--]--></span></button><!----></div></div></div><div class="fifth-para-ad mobile-ads-holder ads-loaded"><span></span></div></div><div class="overdose-container center-content tab-content" id="overdose-container"><div class="title-bg"><span><svg width="24" height="24" viewbox="0 0 24 24" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M7.3125 23.25L0.75 16.6875V7.3125L7.3125 0.75H16.6875L23.25 7.3125V16.6875L16.6875 23.25H7.3125ZM8.25 17.2083L12 13.4583L15.75 17.2083L17.2083 15.75L13.4583 12L17.2083 8.25L15.75 6.79166L12 10.5417L8.25 6.79166L6.79166 8.25L10.5417 12L6.79166 15.75L8.25 17.2083ZM8.1875 21.1667H15.8125L21.1667 15.8125V8.1875L15.8125 2.83331H8.1875L2.83331 8.1875V15.8125L8.1875 21.1667Z" fill="#3557FF"></path></svg></span><h2 class="monograph-content-headline"> Overdose/Missed Dose </h2></div><!----><div><div class="monograph-content"><h3><span>What should I do if I accidentally use too much duloxetine?</span></h3><p dir="ltr"><span>If you or someone else has used too much duloxetine, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.</span></p><h3><span>What should I do if I miss a dose of duloxetine?</span></h3><p dir="ltr"><span>If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.</span></p><p class='udpated-para-lazy'> </p></div></div><div class="fifth-para-ad mobile-ads-holder ads-loaded"><span></span></div></div><!----><div class="bottom-section-holder"><div class="source-bookmark"><div class="source-holder"><button class=""> Sources </button></div><div class="bookmark-links"></div><div class="source-content"></div></div><div class="other-links"><div class="you-might-also-like"><h3>You Might Also Like</h3><!----><div><div class="first-row"><!--[--><div class="links" data-metrics-module="dr-relatedto"><a href="https://www.webmd.com/cold-and-flu/ss/slideshow-cold-or-flu" data-metrics-link="1">Cold or Flu? 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(Cymbalta, Drizalma Sprinkle): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD","meta_description":"Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings","meta_keywords":"Duloxetine (Cymbalta, Drizalma Sprinkle): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD, effectiveness, satisfaction, ease of use, medication, medications, medicine, drug, drugs, prescription drugs, user ratings, drug ratings, drug reviews, rate a drug, treatment, side effects, drug interactions, drug information, medical information, medical advice, warnings, overdose, drug images, over the counter, indications, precautions - WebMD","og_tags":{"image":"https:\u002F\u002Fimg.wbmdstatic.com\u002Fvim\u002Flive\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Flogos\u002Fwebmd\u002Fweb\u002Fwebmd-logo-fb.jpg","image:alt":"WebMD logo"},"canonicalurl":"","is_external_searchable":true,"preconnect":"\u002F\u002Fimg.lb.wbmdstatic.com","meta_title":"Duloxetine (Cymbalta, Drizalma Sprinkle): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD","header_title":"Duloxetine (Cymbalta, Drizalma Sprinkle) - Uses, Side Effects, and More","meta_allowsite":"True","noindex":false},"asset_isdeleted":false,"tugs":[],"assetrelations":[],"newsletterMapping":{"message_id":962,"newsletter_category_id":11,"sample_image_url":"https:\u002F\u002Fimg.webmd.com\u002Fvim\u002Flive\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Fnewsletterpreview\u002Fgood-health.png","title":"Sign up for our free Good Health Newsletter","sub_title":"Get wellness tips to help you live happier and healthier","hover_image_url":"\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Ftocs\u002Fhealthctr\u002FFB_Group_Image\u002Fgoodhealth-cropped.jpg","landing_image_url":"\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Ftocs\u002Fhealthctr\u002FFB_Group_Image\u002Fgoodhealth-cropped.jpg","create_date":"03\u002F12\u002F2019 03:26:38","update_date":"06\u002F07\u002F2022 13:20:37","last_updated":"04\u002F10\u002F2024 06:00:33","default_newsletters_vendor_ids":"WhatsNewWMD,BrandedOffWMD,NewsAlertsWMD","thankYouMessageLink":"https:\u002F\u002Fwww.webmd.com\u002Fnewsletters","thankYouMessageTitle":"Thanks for subscribing!","thankYouMessageSubTitle":"View all of our health and wellness newsletters","thankYouMessageLinkTextButton":"See More"},"headHTML":"\u003Clink rel=\"preload\" as=\"image\" href=\"https:\u002F\u002Fimg.webmd.com\u002Fvim\u002Flive\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Fdrugs\u002Fassets\u002Fdrug-monograph-cms-bg-desktop.jpg\"\u003E","disable_omniture_load":false,"query":{},"canonicalurl":"https:\u002F\u002Fwww.webmd.com\u002Fdrugs\u002F2\u002Fdrug-91491\u002Fcymbalta-oral\u002Fdetails","rootClasses":{}},"monograph_data":{"id":"FDB_91491","title":"Duloxetine (Cymbalta, Drizalma Sprinkle)","content_text":"","primary_topic_id":"4046","drug_name":"Duloxetine (Cymbalta, Drizalma Sprinkle)","is_pem":false,"topic_ids":["4046"],"generic_names":["duloxetine","duloxetine HCl","duloxetine hydrochloride"],"generic_names_mvs":["{\r\n \"name\": \"duloxetine\",\r\n \"monograph_id\": \"1\"\r\n}","{\r\n \"name\": \"duloxetine HCl\",\r\n \"monograph_id\": \"1\"\r\n}","{\r\n \"name\": \"duloxetine hydrochloride\",\r\n \"monograph_id\": \"1\"\r\n}"],"urls":["{\r\n \"type\": \"Desktop\",\r\n \"url\": 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conditions.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fdepression\u002Fmajor-depression\\\"\u003E\u003Cspan\u003EDepression\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fanxiety-panic\u002Fgeneralized-anxiety-disorder\\\"\u003E\u003Cspan\u003EAnxiety\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENerve damage from diabetes that leads to tingling, numbness, burning, or pain, usually in the legs and feet (\u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Fdiabetes-neuropathy\\\"\u003E\u003Cspan\u003Ediabetic peripheral neuropathy\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ELong-term condition that involves sleep problems, fatigue, and pain (\u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Ffibromyalgia\u002Fwhat-is-fibromyalgia\\\"\u003E\u003Cspan\u003Efibromyalgia\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fpain-management\u002Fmusculoskeletal-pain\\\"\u003E\u003Cspan\u003EMusculoskeletal pain\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E that persists\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDuloxetine may also be used for other conditions as determined by your healthcare provider.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EHow does duloxetine work (mechanism of action)?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDuloxetine belongs to a group of medicines called serotonin-norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amount of natural chemicals or \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fbrain\u002Fneurotransmitters-what-to-know\\\"\u003E\u003Cspan\u003Eneurotransmitters\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E called \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fdepression\u002Ffeatures\u002Fserotonin\\\"\u003E\u003Cspan\u003Eserotonin\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E and norepinephrine in the brain. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EHow is duloxetine supplied (dosage forms)?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EBrands and other names\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ECymbalta\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDrizalma Sprinkle\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDosage forms and strengths\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003E20 mg oral delayed-release capsule\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003E30 mg oral delayed-release capsule\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003E40 mg oral delayed-release capsule\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003E60 mg oral delayed-release capsule\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Ch3\u003E\u003Cspan\u003EHow should I store duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDuloxetine should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\",\"common_brand_name\":\"Cymbalta, Drizalma Sprinkle\",\"how_to_use\":\"capsule that is swallowed\",\"drug_interactions\":\"\u003Ch3\u003E\u003Cspan\u003EDoes duloxetine interact with foods or drinks?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EThere are no known interactions between duloxetine and foods or drinks.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EThere are no known interactions between duloxetine and alcohol. However, the risk of liver damage may be increased if you drink alcohol, especially large amounts, while taking duloxetine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EDoes duloxetine interact with other medicines (drug interactions)?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EAlways tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins\u002Fminerals, herbal products, and other supplements you are taking.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EIn particular, make sure that you discuss if you are taking any of the following before taking duloxetine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EA monoamine oxidase inhibitor (MAOI) within the past 2 weeks, which is a medicine usually used for depression or Parkinson’s disease\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ELinezolid, which is a medicine used for bacterial infections\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EThioridazine, which is a medicine for certain mental health conditions\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EA type of medicine called a triptan, such as sumatriptan (Imitrex and others), eletriptan (Relpax), and others, which is commonly used to treat migraines\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EA tricyclic antidepressant, such as amitriptyline, nortriptyline, or protriptyline, even if it is not used for depression\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EAn opioid, such as oxycodone, morphine, codeine, or fentanyl, which is a medicine used for certain types of pain\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EBuspirone, which is a medicine for anxiety\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EA stimulant, such as methylphenidate, lisdexamfetamine, or amphetamine, which is a medicine commonly used to treat attention deficit hyperactivity disorder (ADHD)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESt. John’s wort, which is a supplement that may be used to treat depression\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ETryptophan, which is a supplement that may be used to help the body make proteins and certain brain-signaling chemicals\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EA selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI), which is a medicine commonly used for anxiety and depression\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ELithium, which is a medicine for certain mental health conditions\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EA proton pump inhibitor (PPI), such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (Aciphex)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ECiprofloxacin, which is a medicine used for bacterial infections\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EA medicine used to control your heart rate or rhythm (antiarrhythmic)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EAspirin or a nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen, naproxen, and others, which is in many prescription and OTC products for pain, swelling, and fever\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EWarfarin, which is a blood thinner\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ETheophylline (Theo-24, Elixophyllin), which is a medicine for asthma or certain other breathing problems\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EAny other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, and medicines for anxiety\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EAny other medicine that contains duloxetine\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EMany other medicines may alter the blood levels of duloxetine, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EThis may not be a complete list of medicines that can interact with duloxetine. Always check with your healthcare provider.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\",\"side_effects\":\"\u003Ch3\u003E\u003Cspan\u003EWhat are the most common side effects of duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EThe most common side effects of duloxetine are listed below. Tell your healthcare provider if you have any of these side effects that bother you.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENausea\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDry mouth\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDizziness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDrowsiness or tiredness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EConstipation\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFeeling less hungry \u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESweating\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESlowed growth (see below)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDiarrhea (in children)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EThere may be other side effects of duloxetine that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at \u003C\u002Fspan\u003E\u003Ca href=\\\"http:\u002F\u002Fwww.fda.gov\u002Fmedwatch\\\"\u003E\u003Cspan\u003Ewww.fda.gov\u002Fmedwatch\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at \u003C\u002Fspan\u003E\u003Ca href=\\\"http:\u002F\u002Fwww.health.gc.ca\u002Fmedeffect\\\"\u003E\u003Cspan\u003Ewww.health.gc.ca\u002Fmedeffect\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E or by calling 866-234-2345.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EWhat are the serious side effects of duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EWhile less common, the most serious side effects of duloxetine are described below, along with what to do if they happen.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ESevere Allergic Reactions.\u003C\u002Fstrong\u003E Duloxetine may cause \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fallergies\u002Fallergic-reaction-causes\\\"\u003E\u003Cspan\u003Eallergic reactions\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E, which can be serious. Stop taking duloxetine and get help right away if you have any of the following symptoms of a serious allergic reaction.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EBreathing problems or wheezing\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ERacing heart\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFever or general ill feeling\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESwollen \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fa-to-z-guides\u002Fwhat-are-lymph-nodes\\\"\u003E\u003Cspan\u003Elymph nodes\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESwelling of the face, lips, mouth, tongue, or throat\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ETrouble swallowing or throat tightness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EItching, skin rash, or pale red bumps on the skin called \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fskin-problems-and-treatments\u002Fhives-urticaria-angioedema\\\"\u003E\u003Cspan\u003Ehives\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENausea or vomiting\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDizziness, feeling lightheaded, or fainting\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EStomach cramps\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EJoint pain\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ESuicidal Thoughts or Actions.\u003C\u002Fstrong\u003E Duloxetine or other antidepressants may increase the risk of suicidal thoughts or actions in a small number of children, teenagers, or young adults in the first few months of taking the medicine or when the dose is changed. Depression or other serious mental health conditions are the most important causes of suicidal thoughts or actions. If you or your child is about to harm themselves, call 911 or call or text 988, the Suicide & Crisis Lifeline. Call your healthcare provider right away if you have any of the following symptoms.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENew or increased thoughts of suicide or death\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESuicide attempt\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENew or increased feelings of anxiety, depression, or other unusual changes in your mood or behavior\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ELiver Damage.\u003C\u002Fstrong\u003E Liver damage, also called \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fhepatitis\u002Ftoxic-liver-disease\\\"\u003E\u003Cspan\u003Ehepatotoxicity\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E, can happen when taking duloxetine. Stop taking duloxetine and call your healthcare provider right away if you have any of the following symptoms of liver damage.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENausea or vomiting\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EStomach or belly pain\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFever\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EWeakness or unusual tiredness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EItching\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ELoss of appetite\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ELight-colored poop\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDark-colored urine (pee)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EYour skin or the whites of your eyes turning yellowish in color (also called \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fhepatitis\u002Fjaundice-why-happens-adults\\\"\u003E\u003Cspan\u003Ejaundice\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ELow Blood Pressure Upon Standing (\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fheart\u002Fwhat-is-orthostatic-hypotension-dizzy-standing\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EOrthostatic Hypotension\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E\u003Cstrong\u003E) and Falls. \u003C\u002Fstrong\u003EDuloxetine may cause a sudden drop in blood pressure when standing up from a seated or lying position. This can sometimes lead to fainting or falls. Falls can lead to serious problems including fractures. To help prevent this, be careful not to get up too quickly. If you feel dizzy, sit or lie down right away until the dizziness stops, then take your time getting up again. Tell your healthcare provider right away if you have any of the following symptoms of orthostatic hypotension.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDizziness, feeling lightheaded, or fainting upon standing\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EBlurred vision\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EConfusion\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFeeling weak\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ESerotonin Syndrome. \u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fbrain\u002Fserotonin-syndrome-causes-symptoms-treatments\\\"\u003E\u003Cspan\u003ESerotonin syndrome\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E is when there is too much of a substance called serotonin in your body. Duloxetine can cause serotonin syndrome when it is taken alone or with other medicines that affect serotonin. This condition can be life-threatening. Get emergency help if you have any of the following symptoms of serotonin syndrome.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESweating, fever, or flushing\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EConfusion\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFeeling agitated or restless\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESeeing or hearing unusual things\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDizziness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFast or racing heartbeat\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENausea, vomiting, or diarrhea\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EMuscle twitching, stiffness, or tremor\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESeizures\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EIncreased Blood Pressure (\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fhypertension-high-blood-pressure\u002Fhigh-blood-pressure\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EHypertension\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E\u003Cstrong\u003E). \u003C\u002Fstrong\u003EDuloxetine may increase your blood pressure or make it worse if you have a history of high blood pressure. Call your healthcare provider if your blood pressure increases while taking this medicine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EIf you measure your blood pressure and the top number (systolic) is 180 mm Hg or higher or the bottom number (diastolic) is 120 mm Hg or higher, get medical attention right away. Increases in blood pressure may not be noticeable but look out for any of the following symptoms of severely high blood pressure.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESudden severe headache\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EChest pain\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDizziness or confusion\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ETrouble breathing\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENausea\u002Fvomiting\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EBlurry or other changes to vision\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EAnxiety\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EBuzzing in the ears\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENosebleed\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFeeling of skipped heartbeats\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EAbnormal Bleeding. \u003C\u002Fstrong\u003EPeople taking duloxetine or other antidepressants may have an increased risk of bleeding or bruising. You may be at higher risk if you are also taking aspirin, a nonsteroidal anti-inflammatory drug (NSAID), like ibuprofen or naproxen, or a blood thinner such as warfarin, apixaban (Eliquis), or rivaroxaban (Xarelto). Tell your healthcare provider if you notice any changes in how easily you bruise or bleed.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EExtremely Elevated Mood (Mania).\u003C\u002Fstrong\u003E People with \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fbipolar-disorder\u002Fmental-health-bipolar-disorder\\\"\u003E\u003Cspan\u003Ebipolar disorder\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E can have severe high and low moods. The first symptom of bipolar disorder may be depression. People with bipolar disorder who take an antidepressant, such as duloxetine, may have a higher risk of having mania or a manic episode. Call your healthcare provider right away if you have any of the following symptoms of a manic episode.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EVery increased energy\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESignificant trouble sleeping\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ERacing, fast-paced thoughts\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EReckless behavior\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EUnusually grand ideas\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EExcessive happiness or irritability\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ETalking more or faster than usual\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ESevere Skin Reactions. \u003C\u002Fstrong\u003Eduloxetine can cause severe skin reactions called \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fskin-problems-and-treatments\u002Fstevens-johnson-syndrome\\\"\u003E\u003Cspan\u003EStevens-Johnson Syndrome (SJS)\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E and \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fskin-problems-and-treatments\u002Fwhat-is-toxic-epidermal-necrolysis\\\"\u003E\u003Cspan\u003EToxic Epidermal Necrolysis (TEN)\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E that can lead to death if not treated. If you develop a rash, stop duloxetine and call your healthcare provider right away. Get emergency help right away if you have any of the following symptoms of SJS or TEN.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EPainful red or purple skin that looks burned and peels off\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFlat red rash or blisters on your skin, mouth, nose, and genitals\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ERed, painful, watery eyes\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EGlaucoma. \u003C\u002Fstrong\u003EDuloxetine may increase pressure inside the eye and cause or worsen narrow-angle\u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Feye-health\u002Fglaucoma-eyes\\\"\u003E\u003Cspan\u003E glaucoma\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E, which can lead to blindness. Tell your healthcare provider right away if you have any of the following symptoms of glaucoma.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ELoss of vision\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EEye pain or redness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESevere headache or vomiting\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESeeing bright, colorful circles around lights (vision halos)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ESeizures. \u003C\u002Fstrong\u003ESome people who have taken duloxetine have reported having \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fepilepsy\u002Funderstanding-seizures-basics\\\"\u003E\u003Cspan\u003Eseizures\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E. There are many different types of seizures and some of them are not easy to recognize. Stop taking duloxetine and call your healthcare provider if you have any of the following signs that a seizure is happening or could happen.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EMuscle twitching, jerking, spasms, tremors, or other uncontrolled movements\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EStiffening of your arms and legs\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFeeling anxious, nervous, confused, or a sense of dread\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFeeling dizzy or lightheaded\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFalling or losing consciousness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ELow Sodium Level (\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fa-to-z-guides\u002Fwhat-is-hyponatremia\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EHyponatremia\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E\u003Cstrong\u003E). \u003C\u002Fstrong\u003EDuloxetine may cause low sodium levels. Stop taking duloxetine and call your healthcare provider if you have any of the following symptoms of a low sodium level.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EHeadache\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDrowsiness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EMuscle weakness or cramps\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENausea, vomiting, or loss of appetite\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ETiredness or sleepiness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDizziness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EWeight gain\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ERestlessness or irritability\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EChange in your mental condition such as \u003C\u002Fspan\u003E\u003Ca href=\\\"https:\u002F\u002Fwww.webmd.com\u002Fschizophrenia\u002Fwhat-are-hallucinations\\\"\u003E\u003Cspan\u003Ehallucinations\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E, confusion, decreased awareness, or alertness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESeizures\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EInability to Empty Bladder (Urinary Retention).\u003C\u002Fstrong\u003E Duloxetine might make it harder to empty your bladder, especially if you already have a blockage. Call your healthcare provider right away if you are having trouble peeing or cannot empty your bladder.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ESexual Problems. \u003C\u002Fstrong\u003ETaking duloxetine or another selective serotonin reuptake inhibitor (SSRI) may cause sexual problems. Tell your healthcare provider if you have any of the following sexual problems. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDecreased sex drive\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDelayed ejaculation or unable to have an ejaculation\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EProblems getting or keeping an erection\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDelayed orgasm or unable to have an orgasm\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\",\"overdose_and_misseddose\":\"\u003Ch3\u003E\u003Cspan\u003EWhat should I do if I accidentally use too much duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EIf you or someone else has used too much duloxetine, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EWhat should I do if I miss a dose of duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EIf you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E \u003C\u002Fp\u003E\",\"warnings_and_Precautions\":\"\u003Ch3\u003E\u003Cspan\u003EWho should not use duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EAllergies to Ingredients.\u003C\u002Fstrong\u003E People who are allergic to any of the following should not take duloxetine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDuloxetine\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ECymbalta\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDrizalma Sprinkle\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EAny of the ingredients in the specific product dispensed\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EYour pharmacist can tell you all of the ingredients in the specific duloxetine products they stock.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EDrug Interactions. \u003C\u002Fstrong\u003EDuloxetine should not be taken while you are using certain other medicines. Before taking duloxetine, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins\u002Fminerals, herbal products, and other supplements you are taking. See the Interactions section for more details.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EKidney Problems.\u003C\u002Fstrong\u003E Duloxetine should not be used if your kidneys are not working as well as they should be. If there is a concern about the health of your kidneys, your healthcare provider may do tests to determine if they are working well enough to take this medicine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ELiver Problems. \u003C\u002Fstrong\u003EDuloxetine should not be used if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EWhat should I know about duloxetine before using it?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDo not take duloxetine unless it has been prescribed to you by a healthcare provider. Take it as prescribed.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDo not share duloxetine with other people, even if they have the same condition as you. It may harm them.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EKeep duloxetine out of the reach of children.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDo not chew or crush duloxetine delayed-release capsules. They should be swallowed whole. Some duloxetine delayed-release capsules can be opened up to be given through a feeding tube or mixed with applesauce for people who have trouble swallowing capsules. If you have a feeding tube or trouble swallowing capsules, talk to your pharmacist for specific directions on how to do this.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDuloxetine can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how duloxetine affects you.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDuloxetine can make you feel less hungry, which may slow down growth in children and adolescents who are still growing. Talk with the healthcare provider if you have any concerns about how your child is growing.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EDo not stop taking duloxetine without talking to your healthcare provider. Stopping too quickly may cause serious side effects. Call your healthcare provider right away if you have any of the following symptoms.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EAnxiety, irritability, or high or low mood\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EFeeling restless \u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EChanges in sleep habits\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EHeadache\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESweating or shaking\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ENausea or diarrhea\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDizziness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EElectric-shock like feelings\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EConfusion\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EIf you have diabetes, duloxetine may increase your blood sugar levels. Talk with your healthcare provider about how to maintain healthy blood sugar levels.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EPeople who are 65 or older can be at greater risk for some side effects from duloxetine. Talk to your healthcare provider about your risks if you are in this age group.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EWhat should I tell my healthcare provider before using duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003ETell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins\u002Fminerals, herbal products, and other supplements you are taking. This will help them determine if duloxetine is right for you.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003EIn particular, make sure that you discuss any of the following.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003ECurrent and Past Health Conditions. \u003C\u002Fstrong\u003ETell your healthcare provider if you have any of the following.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EHeart problems\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EHigh blood pressure\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDiabetes\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EGlaucoma\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESeizures\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EMental health conditions such as bipolar disorder, mania\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ELow blood sodium levels\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ESlow emptying of your stomach\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EBleeding problems\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003EDrink alcohol, especially in large amounts\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\\\"ltr\\\" aria-level=\\\"1\\\"\u003E\u003Cspan\u003ETrouble peeing or emptying your bladder\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EPregnancy. \u003C\u002Fstrong\u003ETaking duloxetine later in pregnancy may lead to an increased risk of certain problems in your unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take duloxetine while you are pregnant or trying to become pregnant. If you become pregnant while taking duloxetine, you can register for the National Pregnancy Registry for Antidepressants by calling 844-405-6185 or at www.womensmentalhealth.org\u002Fresearch\u002Fpregnancyregistry\u002Fantidepressants. This registry collects safety information about the use of antidepressant medicines during pregnancy.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\\\"ltr\\\"\u003E\u003Cspan\u003E\u003Cstrong\u003EBreastfeeding. \u003C\u002Fstrong\u003EDuloxetine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take duloxetine while breastfeeding. If you breastfeed while taking duloxetine, call your healthcare provider right away if your baby becomes sleepy, or is not feeding well or gaining weight.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\",\"about\":\"\"}}","drug_type":["Prescription Only"],"related_content":["{\r\n \"source\": \"FDBClient\",\r\n \"type\": \"Article\",\r\n \"seqnum\": \"5\",\r\n \"title\": \"Cold or Flu? How to Tell\",\r\n \"linkurl\": \"https:\u002F\u002Fwww.webmd.com\u002Fcold-and-flu\u002Fss\u002Fslideshow-cold-or-flu\",\r\n \"link_url\": \"https:\u002F\u002Fwww.webmd.com\u002Fcold-and-flu\u002Fss\u002Fslideshow-cold-or-flu\"\r\n}","{\r\n \"source\": \"FDBClient\",\r\n \"type\": \"Article\",\r\n \"seqnum\": \"18\",\r\n \"title\": \"Treating and Managing Eczema Pigmentation\",\r\n \"linkurl\": \"https:\u002F\u002Fwww.webmd.com\u002Fskin-problems-and-treatments\u002Feczema\u002Feczema-pigmentation-treating-managing\",\r\n \"link_url\": \"https:\u002F\u002Fwww.webmd.com\u002Fskin-problems-and-treatments\u002Feczema\u002Feczema-pigmentation-treating-managing\"\r\n}","{\r\n \"source\": \"FDBClient\",\r\n \"type\": \"Article\",\r\n \"seqnum\": \"15\",\r\n \"title\": \"Treating Opioid Use Disorder With Medications\",\r\n \"linkurl\": \"https:\u002F\u002Fwww.webmd.com\u002Fmental-health\u002Faddiction\u002Fbreaking-an-addiction-to-painkillers-treatment-overvew\",\r\n \"link_url\": \"https:\u002F\u002Fwww.webmd.com\u002Fmental-health\u002Faddiction\u002Fbreaking-an-addiction-to-painkillers-treatment-overvew\"\r\n}","{\r\n \"source\": \"FDBClient\",\r\n \"type\": \"Article\",\r\n \"seqnum\": \"19\",\r\n \"title\": \"Choosing the Right Medications for Colds and Flu\",\r\n \"linkurl\": \"https:\u002F\u002Fsymptoms.webmd.com\u002Fcold-flu-map\u002Fcm\u002Fotc-fast-relief-cold-flu\",\r\n \"link_url\": \"https:\u002F\u002Fsymptoms.webmd.com\u002Fcold-flu-map\u002Fcm\u002Fotc-fast-relief-cold-flu\"\r\n}","{\r\n \"source\": \"FDBClient\",\r\n \"type\": \"Article\",\r\n \"seqnum\": \"20\",\r\n \"title\": \"How to Treat Colds and Flu at Home: Dos and Don'ts\",\r\n \"linkurl\": \"https:\u002F\u002Fsymptoms.webmd.com\u002Fcold-flu-map\u002Fstop-spread-cold-flu\",\r\n \"link_url\": \"https:\u002F\u002Fsymptoms.webmd.com\u002Fcold-flu-map\u002Fstop-spread-cold-flu\"\r\n}","{\r\n \"source\": \"FDBClient\",\r\n \"type\": \"Article\",\r\n \"seqnum\": \"10\",\r\n \"title\": 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Johnston, PharmD, BCPS","availability_s":"prescription only, generic available for some forms","pronunciation_s":"sim-BALL-tah , dri-ZAL-mah, doo-LOX-e-teen","monograph_type_s":"Generic Drug Monograph","writted_by_link_s":"https:\u002F\u002Fwww.webmd.com\u002Fbio\u002Fbeth-johnston","reviewed_by_link_s":"https:\u002F\u002Fwww.webmd.com\u002Fbio\u002Fthomas-franko","writted_by_image_s":"https:\u002F\u002Fimg.webmd.com\u002Fvim\u002Flive\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Farticles\u002Fbiographies\u002FBeth_Johnston_382x382.jpg","reviewed_by_image_s":"https:\u002F\u002Fimg.webmd.com\u002Fvim\u002Flive\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Farticles\u002Fbiographies\u002Fthomas-franko-382x382.jpg","medically_reviewed_by_s":"Thomas S. Franko, PharmD","updateddate_s":"Oct 08, 2024","webmd_pagedata_nis":"{\"meta_title\":\"Duloxetine (Cymbalta, Drizalma Sprinkle): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD\",\"header_title\":\"Duloxetine (Cymbalta, Drizalma Sprinkle) - Uses, Side Effects, and More\",\"meta_description\":\"Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings\",\"meta_allowsite\":\"True\",\"noindex\":false}","totalreviewcount":4696,"overallrating":"3.5","content_tags":""},"crosslinks_data":{"uses":"RENDERED","common_brand_name":"Cymbalta, Drizalma Sprinkle","how_to_use":"capsule that is swallowed","drug_interactions":"RENDERED","side_effects":"RENDERED","overdose_and_misseddose":"\u003Ch3\u003E\u003Cspan\u003EWhat should I do if I accidentally use too much duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EIf you or someone else has used too much duloxetine, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EWhat should I do if I miss a dose of duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EIf you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E \u003C\u002Fp\u003E","warnings_and_Precautions":"\u003Ch3\u003E\u003Cspan\u003EWho should not use duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003E\u003Cstrong\u003EAllergies to Ingredients.\u003C\u002Fstrong\u003E People who are allergic to any of the following should not take duloxetine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDuloxetine\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ECymbalta\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDrizalma Sprinkle\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EAny of the ingredients in the specific product dispensed\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EYour pharmacist can tell you all of the ingredients in the specific duloxetine products they stock.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003E\u003Cstrong\u003EDrug Interactions. \u003C\u002Fstrong\u003EDuloxetine should not be taken while you are using certain other medicines. Before taking duloxetine, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins\u002Fminerals, herbal products, and other supplements you are taking. See the Interactions section for more details.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003E\u003Cstrong\u003EKidney Problems.\u003C\u002Fstrong\u003E Duloxetine should not be used if your kidneys are not working as well as they should be. If there is a concern about the health of your kidneys, your healthcare provider may do tests to determine if they are working well enough to take this medicine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003E\u003Cstrong\u003ELiver Problems. \u003C\u002Fstrong\u003EDuloxetine should not be used if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EWhat should I know about duloxetine before using it?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDo not take duloxetine unless it has been prescribed to you by a healthcare provider. Take it as prescribed.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDo not share duloxetine with other people, even if they have the same condition as you. It may harm them.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EKeep duloxetine out of the reach of children.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDo not chew or crush duloxetine delayed-release capsules. They should be swallowed whole. Some duloxetine delayed-release capsules can be opened up to be given through a feeding tube or mixed with applesauce for people who have trouble swallowing capsules. If you have a feeding tube or trouble swallowing capsules, talk to your pharmacist for specific directions on how to do this.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDuloxetine can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how duloxetine affects you.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDuloxetine can make you feel less hungry, which may slow down growth in children and adolescents who are still growing. Talk with the healthcare provider if you have any concerns about how your child is growing.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDo not stop taking duloxetine without talking to your healthcare provider. Stopping too quickly may cause serious side effects. Call your healthcare provider right away if you have any of the following symptoms.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EAnxiety, irritability, or high or low mood\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EFeeling restless \u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EChanges in sleep habits\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EHeadache\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ESweating or shaking\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ENausea or diarrhea\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDizziness\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EElectric-shock like feelings\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EConfusion\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EIf you have diabetes, duloxetine may increase your blood sugar levels. Talk with your healthcare provider about how to maintain healthy blood sugar levels.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EPeople who are 65 or older can be at greater risk for some side effects from duloxetine. Talk to your healthcare provider about your risks if you are in this age group.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EWhat should I tell my healthcare provider before using duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003ETell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins\u002Fminerals, herbal products, and other supplements you are taking. This will help them determine if duloxetine is right for you.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EIn particular, make sure that you discuss any of the following.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003E\u003Cstrong\u003ECurrent and Past Health Conditions. \u003C\u002Fstrong\u003ETell your healthcare provider if you have any of the following.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EHeart problems\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EHigh blood pressure\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDiabetes\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EGlaucoma\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ESeizures\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EMental health conditions such as bipolar disorder, mania\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ELow blood sodium levels\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ESlow emptying of your stomach\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EBleeding problems\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDrink alcohol, especially in large amounts\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ETrouble peeing or emptying your bladder\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003E\u003Cstrong\u003EPregnancy. \u003C\u002Fstrong\u003ETaking duloxetine later in pregnancy may lead to an increased risk of certain problems in your unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take duloxetine while you are pregnant or trying to become pregnant. If you become pregnant while taking duloxetine, you can register for the National Pregnancy Registry for Antidepressants by calling 844-405-6185 or at www.womensmentalhealth.org\u002Fresearch\u002Fpregnancyregistry\u002Fantidepressants. This registry collects safety information about the use of antidepressant medicines during pregnancy.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003E\u003Cstrong\u003EBreastfeeding. \u003C\u002Fstrong\u003EDuloxetine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take duloxetine while breastfeeding. If you breastfeed while taking duloxetine, call your healthcare provider right away if your baby becomes sleepy, or is not feeding well or gaining weight.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E","about":"","title":"Duloxetine (Cymbalta, Drizalma Sprinkle)","generic_name":"duloxetine,duloxetine HCl,duloxetine hydrochloride","pronunciation":"sim-BALL-tah , dri-ZAL-mah, doo-LOX-e-teen","drug_class":"selective serotonin and norepinephrine reuptake inhibitor (SNRI)","availability":"prescription only, generic available for some forms","reviewed_by_image":"https:\u002F\u002Fimg.webmd.com\u002Fvim\u002Flive\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Farticles\u002Fbiographies\u002Fthomas-franko-382x382.jpg","reviewed_by_link":"https:\u002F\u002Fwww.webmd.com\u002Fbio\u002Fthomas-franko","medically_reviewed_by":"Thomas S. Franko, PharmD","writted_by_link":"https:\u002F\u002Fwww.webmd.com\u002Fbio\u002Fbeth-johnston","written_by":"Beth Johnston, PharmD, BCPS","sources":"\u003Cul\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ECymbalta (Eli Lilly) US Medication Guide, August 2023.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ECymbalta (Eli Lilly) US Prescribing Information, August 2023.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDrizalma Sprinkle (Sun Pharmaceutical) US Instructions for Use, July 2021.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDrizalma Sprinkle (Sun Pharmaceutical) US Medication Guide, May 2024.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDrizalma Sprinkle (Sun Pharmaceutical) US Prescribing Information, August 2023.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E","updatedat":"Oct 08, 2024","monograph_type":"Generic Drug Monograph","how_its_used":"capsule that is swallowed","description":"\u003Ch3\u003E\u003Cspan\u003EWhat is duloxetine used for?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDuloxetine is commonly used to treat the following conditions.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Ca href=\"https:\u002F\u002Fwww.webmd.com\u002Fdepression\u002Fmajor-depression\"\u003E\u003Cspan\u003EDepression\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Ca href=\"https:\u002F\u002Fwww.webmd.com\u002Fanxiety-panic\u002Fgeneralized-anxiety-disorder\"\u003E\u003Cspan\u003EAnxiety\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ENerve damage from diabetes that leads to tingling, numbness, burning, or pain, usually in the legs and feet (\u003C\u002Fspan\u003E\u003Ca href=\"https:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Fdiabetes-neuropathy\"\u003E\u003Cspan\u003Ediabetic peripheral neuropathy\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ELong-term condition that involves sleep problems, fatigue, and pain (\u003C\u002Fspan\u003E\u003Ca href=\"https:\u002F\u002Fwww.webmd.com\u002Ffibromyalgia\u002Fwhat-is-fibromyalgia\"\u003E\u003Cspan\u003Efibromyalgia\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E)\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Ca href=\"https:\u002F\u002Fwww.webmd.com\u002Fpain-management\u002Fmusculoskeletal-pain\"\u003E\u003Cspan\u003EMusculoskeletal pain\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E that persists\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDuloxetine may also be used for other conditions as determined by your healthcare provider.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EHow does duloxetine work (mechanism of action)?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDuloxetine belongs to a group of medicines called serotonin-norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amount of natural chemicals or \u003C\u002Fspan\u003E\u003Ca href=\"https:\u002F\u002Fwww.webmd.com\u002Fbrain\u002Fneurotransmitters-what-to-know\"\u003E\u003Cspan\u003Eneurotransmitters\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E called \u003C\u002Fspan\u003E\u003Ca href=\"https:\u002F\u002Fwww.webmd.com\u002Fdepression\u002Ffeatures\u002Fserotonin\"\u003E\u003Cspan\u003Eserotonin\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan\u003E and norepinephrine in the brain. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Ch3\u003E\u003Cspan\u003EHow is duloxetine supplied (dosage forms)?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EBrands and other names\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003ECymbalta\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003EDrizalma Sprinkle\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDosage forms and strengths\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003E20 mg oral delayed-release capsule\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003E30 mg oral delayed-release capsule\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003E40 mg oral delayed-release capsule\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli dir=\"ltr\" aria-level=\"1\"\u003E\u003Cspan\u003E60 mg oral delayed-release capsule\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Ch3\u003E\u003Cspan\u003EHow should I store duloxetine?\u003C\u002Fspan\u003E\u003C\u002Fh3\u003E\u003Cp dir=\"ltr\"\u003E\u003Cspan\u003EDuloxetine should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E","common_brand":"Cymbalta, Drizalma Sprinkle","precautions":"RENDERED","overdose":"RENDERED","header_title":"Duloxetine (Cymbalta, Drizalma Sprinkle) - Uses, Side Effects, and More"},"selected_survey_obj":{"title":"no response"},"drug_monograph_url":"","activetab":"uses","location":{},"fetchProviders":{},"relatedLinks":[],"warning":"","pd_rendered":false,"pd_data_updated":false,"pd_data":[],"fdb_id":"FDB_91491","route":{"fullPath":"\u002Fdrugs\u002F2\u002Fdrug-91491\u002Fcymbalta-oral\u002Fdetails","path":"\u002Fdrugs\u002F2\u002Fdrug-91491\u002Fcymbalta-oral\u002Fdetails","query":{},"hash":"","params":{"id":"91491","name":"cymbalta-oral","articleid":"091e9c5e820cb27e","channelid":"1036"},"matched":[{"path":"\u002Fdrugs\u002F2\u002Fdrug-:id\u002F:name\u002Fdetails","meta":{},"props":{"default":false},"children":[],"instances":{},"leaveGuards":{},"updateGuards":{},"enterCallbacks":{},"components":{"default":{}}}],"meta":{},"href":"\u002Fdrugs\u002F2\u002Fdrug-91491\u002Fcymbalta-oral\u002Fdetails"},"cms":{"friendlyURLData":null,"siteFronts":false,"modules":{"091e9c5e820cb8ef":{"module_settings":{"chronic_id":"091e9c5e820cb8ef","title":"webmd-drugs-monograph-store","object_type":"wbmd_pb_module","wbmd_pb_module_category":"","wbmd_pb_module_xsl":{"path":"\u002Fwebmd\u002FPageBuilder_Assets\u002FXSL\u002FHTML\u002Fvue-webmd-drugs-store.xsl","object_type":"wbmd_pb_xsl","chronic_id":"091e9c5e820a95c6"},"Class":"HTML"}},"091e9c5e820cb8f0":{"module_settings":{"chronic_id":"091e9c5e820cb8f0","title":"webmd-drugs-monograph-router","object_type":"wbmd_pb_module","wbmd_pb_module_category":"","wbmd_pb_module_xsl":{"path":"\u002Fwebmd\u002FPageBuilder_Assets\u002FXSL\u002FHTML\u002Fvue-webmd-drugs-monograph-router.xsl","object_type":"wbmd_pb_xsl","chronic_id":"091e9c5e820a9a2b"},"Class":"HTML"}},"091e9c5e813b6dde":{"module_data":{"shared_Modules":{"SharedModules":[{"module_settings":{"title":"hicbn"},"module_data":{"groups":{"group":[{"group_name":"Conditions","link_items":{"link_item":[{"link_text":"ADD\u002FADHD","link_friendlyUrl":"https:\u002F\u002Fwww.webmd.com\u002Fadd-adhd\u002Fdefault.htm"},{"link_text":"Allergies","link_friendlyUrl":"https:\u002F\u002Fwww.webmd.com\u002Fallergies\u002Fdefault.htm"},{"link_text":"Arthritis","link_friendlyUrl":"https:\u002F\u002Fwww.webmd.com\u002Farthritis\u002Fdefault.htm"},{"link_text":"Atrial 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