Neuroscience with Imaging Mass Cytometry

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neural tissues clearly</h2> <p>The high heterogeneity and autofluorescence of brain and neural tissue present technical challenges when using conventional imaging techniques to decipher different cell types and intricate spatial relationships in the study of neurodegenerative disease or neuro-oncology.</p> <p>Imaging Mass Cytometry™ (IMC™) produces clear, easy-to-interpret signals from neural tissue, <strong>eliminating autofluorescence interference</strong> with metal-labeled antibodies.</p> <a href="/TechnicalDocuments/Lookbooks/Neuro_Look_Book_FLDM-01382_Rev_01.pdf" target="_blank" class="primary-btn mt-3 align-self-start" type="internal">Download neuroscience lookbook</a> </div> <div class="d-none d-lg-block col-lg-2"></div> <div class="d-flex px-5 py-3 p-lg-0 col-12 col-lg-3 justify-content-center align-items-center"> <picture data-alt="" 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" src="/FluidigmSite_Assets/PrdSrv-Tech_ImagingMassCytometry/Images/IMC_Neuroscience_neuro-oncology-IMCpanel-human-mouse-tumors.jpg" style="width: 100%;" /> <p style="color:#999999; line-height:1.175rem !important;"><span class="font-15"><span>Application of neuro-oncology IMC panel on human and mouse tumors of mixed or non-glial origin </span></span></p> </div> <div class="Width60 sidebysideRtItem"> <h2><span class="color-secondary-blue">Mapping the neuro-oncological cellular landscape</span></h2> <hr /> <p>Spatial phenotyping with IMC enables comprehensive assessment of the structural and cellular organization of the tumor microenvironment in neural tissues, including activation of immuno-oncological processes.</p> <p><a class="secondary-btn" href="https://fluidigm.my.salesforce.com/sfc/p/#700000009DAw/a/4u000000qN2G/6.amCYZjCHl_YIR2X904BSfzBEBFAtLuEEZrps3NGxI" target="_blank">See the neuro-oncology poster</a></p> <p><a class="secondary-btn" href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u000000qPuj/a0XpQvN27vRFU7WHjIi7sG1jiK9SCXcl_pH.fzRgrTQ" target="_blank">See the neuro-oncology poster summary</a></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="workflows-anchor" class="py-5 "> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <div class="sidebysideContainer"> <div class="sidebysideLtItem Width50"> <h2><span class="color-secondary-blue">Neuro-oncology panel kits for Imaging Mass Cytometry</span></h2> <hr /> <p>Identify neural cell lineages and immune cell infiltration in spatial context to better understand disease progression.</p> <p>Try one of our ready-made panels or bundles or explore our comprehensive catalog of immune markers. Our easy panel design process makes integrating new markers simple.</p> <p><a class="primary-btn-purple" href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u0000010poW/4P79Wa_WPrYgGqwKr9uMyIgm0bGuIvXWObW5wVTcBL0" target="_blank">See flyer</a></p>   <div class="bg-grad-blue" style="padding:15px;"> <h4><span style="color:#ffffff;">Our products:</span></h4> <ul> <li><span class="font-18"><u><span style="color:#ffffff;">• </span><a href="https://store.standardbio.com/product_detail/guest-catalog/201508no"><span style="color:#ffffff;"><span style="text-decoration:underline;">Maxpar® Human Neuro-Oncology IMC Bundle</span></span></a></u></span></li> <li><span class="font-18"><u><span style="color:#ffffff;">• </span><a href="https://store.standardbio.com/product_detail/featured-flow/201337"><span style="color:#ffffff;"><span style="text-decoration:underline;">Maxpar Neuro Phenotyping IMC Panel Kit</span></span></a></u></span></li> <li><span class="font-18"><u><span style="color:#ffffff;">• </span><a href="https://store.standardbio.com/product_detail/guest-catalog/9100005no"><span style="color:#ffffff;"><span style="text-decoration:underline;">Maxpar OnDemand™ Mouse Neuro-Oncology IMC Bundle</span></span></a></u></span></li> <li><span class="font-18"><u><span style="color:#ffffff;">• </span><a href="https://store.standardbio.com/imaging_consumables?"><span style="color:#ffffff;"><span style="text-decoration:underline;">Maxpar or Maxpar OnDemand antibodies</span></span></a></u></span></li> </ul> </div> </div> <div class="Width50" style="margin-top:65px;"> <div class="bg-white" style="padding:10px 15px;"> <p>Learn about the power of the high-plex Maxpar OnDemand Mouse Neuro-Oncology IMC Bundle to enable single-cell analysis for fast and accurate brain tumor and immune cell phenotyping.</p> <p><a class="primary-btn-purple" href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u0000010qLX/GCZ7mqpHVGiIDAHVHxU4VfCth1DVwiK3zBTl5XVj7uI" target="_blank">Read the application note</a></p> </div> <div class="bg-white" style="padding:15px;"><img alt="Maxpar OnDemand Mouse Neuro-Oncology IMC Bundle" src="/FluidigmSite_Assets/PrdSrv-Tech_ImagingMassCytometry/Images/IMC_Neuroscience_Maxpar-OnDemand-Mouse-NeuroOncology-IMC-Bundle.jpg" style="width: 100%;" /></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="neurodegeneration-anchor" class="py-5 bg-very-light-gray"> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <h2><span class="color-secondary-blue">Study neurodegeneration spatial complexity in context</span></h2> <hr /> <p>Pathological proteins have emerged as a common mechanism for the progression of various neurodegenerative diseases. Discover the spatial distribution of these key proteins in neural tissues using pre-designed IMC panels for the study of neurodegenerative diseases in formalin-fixed, paraffin-embedded (FFPE) tissue sections.</p> <p><a class="primary-btn-purple" href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u000000dmQK/71sHPE0kMMf9.Fux_LfbL4fLymed1tKBTcds2ly.SLE" target="_blank">SEE FLYER</a></p> <p><a class="primary-btn-purple" href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u000000dmji/2LL2CP_B5SXcCvpu4j_2HVX406S2YeBMDmMp4sr7lDM" target="_blank">View Application note</a></p> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_overlap-scroller pimcore_area_content "> <div id="-anchor" class="bg-magenta-alt"> <div class="container-fluid pb-5 overlap-scroller "> <div class="row"> <div class="col-lg-1 d-none d-lg-block"></div> <div class="col-12 col-lg-3 pt-5 pe-2 pe-lg-3 d-flex flex-column justify-content-center color-white"> <h2 class="text-uppercase color-primary-gray pt-0"></h2> <h2><span class="color-secondary-blue">Products</span></h2> <hr /> <p>Get critical insights into common neurodegenerative proteinopathies or mixed pathologies as seen in synucleinopathy and tauopathy neurodegenerative conditions.</p> <div class="primary-btn-alt d-inline-block mt-3"> </div> </div> <div class="col-lg-1 d-none d-lg-block"></div> <div class="col-12 col-lg-7 card-container d-flex py-5 card-width-sm ps-0"> <span class="col autofocus" autofocus></span> <div class="col related-product-card small-p text-center"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Alzheimer's Disease IMC Panel, 3 Antibodies </h4> </div> <picture data-alt="" data-default-src="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14510__card-thumbnail-product/9100007.png"> <source srcset="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14510__card-thumbnail-product/9100007.png 1x, /Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14510__card-thumbnail-product/9100007@2x.png 2x" type="image/png" /> <img alt="" src="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14510__card-thumbnail-product/9100007.png" /> </picture> <div class="card-body px-4 py-1"> <h3 class="card-text pt-0 clamp-3">The Alzheimer’s Disease IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against Tau, phosphorylated Tau (pTau) and amyloid precursor protein (APP). </h3> </div> <div class="card-footer border-0 px-4 pt-1 pb-2 bg-white d-flex align-items-center justify-content-end"> <a href="https://store.standardbio.com/product_detail/guest-catalog/9100007" class="secondary-btn">Learn more</a> </div> </div> </div> <div class="col related-product-card small-p text-center"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Parkinson's Disease IMC Panel, 3 Antibodies </h4> </div> <picture data-alt="" data-default-src="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14558__card-thumbnail-product/9100006.png"> <source srcset="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14558__card-thumbnail-product/9100006.png 1x, /Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14558__card-thumbnail-product/9100006@2x.png 2x" type="image/png" /> <img alt="" src="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14558__card-thumbnail-product/9100006.png" /> </picture> <div class="card-body px-4 py-1"> <h3 class="card-text pt-0 clamp-3">The Parkinson’s Disease IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against αSynuclein (αSyn), phosphorylated αSynuclein (p-αSyn) and tyrosine hydroxylase (TH).  </h3> </div> <div class="card-footer border-0 px-4 pt-1 pb-2 bg-white d-flex align-items-center justify-content-end"> <a href="https://store.standardbio.com/product_detail/guest-catalog/9100006" class="secondary-btn">Learn more</a> </div> </div> </div> <div class="col related-product-card small-p text-center"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Multiple Sclerosis IMC Panel, 3 Antibodies </h4> </div> <picture data-alt="" data-default-src="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14559__card-thumbnail-product/9100008.jpg"> <source srcset="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14559__card-thumbnail-product/9100008.jpg 1x, /Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14559__card-thumbnail-product/9100008@2x.jpg 2x" type="image/jpeg" /> <img alt="" src="/Store/Cytometry_And_Tissue_Imaging/Consumables_Reagents/image-thumb__14559__card-thumbnail-product/9100008.jpg" /> </picture> <div class="card-body px-4 py-1"> <h3 class="card-text pt-0 clamp-3">The Multiple Sclerosis IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against human- and mouse-reactive myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and pan-axonal neurofilament (NF) protein.  </h3> </div> <div class="card-footer border-0 px-4 pt-1 pb-2 bg-white d-flex align-items-center justify-content-end"> <a href="https://store.standardbio.com/product_detail/guest-catalog/9100008" class="secondary-btn">Learn more</a> </div> </div> </div> <div class="col related-product-card small-p text-center"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Proteinopathies IMC Panel, 5 Antibodies </h4> </div> <picture data-alt="" data-default-src="/FluidigmSite_Assets/Rsrc_Blog/Images/image-thumb__14575__card-thumbnail-product/9100009.png"> <source srcset="/FluidigmSite_Assets/Rsrc_Blog/Images/image-thumb__14575__card-thumbnail-product/9100009.png 1x, /FluidigmSite_Assets/Rsrc_Blog/Images/image-thumb__14575__card-thumbnail-product/9100009@2x.png 2x" type="image/png" /> <img alt="" src="/FluidigmSite_Assets/Rsrc_Blog/Images/image-thumb__14575__card-thumbnail-product/9100009.png" /> </picture> <div class="card-body px-4 py-1"> <h3 class="card-text pt-0 clamp-3">The Proteinopathies IMC Panel, 5 Antibodies is a bundle of 5 verified Maxpar OnDemand Antibodies against Tau, pTau, αSyn, p-αSyn, and APP. By leveraging these validated antibodies, researchers can visualize cellular landscape of common neurodegenerative proteinopathies such as Alzheimer’s disease, Parkinson’s disease, Parkinson’s disease with dementia, Lewy body dementia, and similar conditions. This panel is optimized for use in FFPE tissue sections. APP, Tau, and αSyn are human and mouse reactive, while p-αSyn and pTau recognize human epitopes [S129] and [S202/T205], respectively, and can be used in mouse models that exogenously express these human proteins. </h3> </div> <div class="card-footer border-0 px-4 pt-1 pb-2 bg-white d-flex align-items-center justify-content-end"> <a href="https://store.standardbio.com/product_detail/guest-catalog/9100009" class="secondary-btn">Learn more</a> </div> </div> </div> <div class="col related-product-card small-p text-center"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">SynTau Mixed Pathology IMC Panel, 4 Antibodies </h4> </div> <picture data-alt="" data-default-src="/FluidigmSite_Assets/Rsrc_Blog/Images/image-thumb__14576__card-thumbnail-product/9100010.png"> <source srcset="/FluidigmSite_Assets/Rsrc_Blog/Images/image-thumb__14576__card-thumbnail-product/9100010.png 1x, /FluidigmSite_Assets/Rsrc_Blog/Images/image-thumb__14576__card-thumbnail-product/9100010@2x.png 2x" type="image/png" /> <img alt="" src="/FluidigmSite_Assets/Rsrc_Blog/Images/image-thumb__14576__card-thumbnail-product/9100010.png" /> </picture> <div class="card-body px-4 py-1"> <h3 class="card-text pt-0 clamp-3">The SynTau Mixed Pathology IMC Panel, 4 Antibodies is a bundle of 4 verified Maxpar OnDemand Antibodies designed for unraveling the complexities of mixed pathologies as seen in synucleinopathy and tauopathy neurodegenerative conditions. These antibodies specifically target Tau, pTau, αSyn, and p-αSyn. This panel is optimized for use in FFPE tissue sections and can be used in mouse models that exogenously contain human epitopes for p-αSyn and pTau. Both Tau and αSyn are cross-reactive for human- and mouse-specific targets, while p-αSyn and pTau recognize human epitopes [S129] and [S202/T205], respectively. </h3> </div> <div class="card-footer border-0 px-4 pt-1 pb-2 bg-white d-flex align-items-center justify-content-end"> <a href="https://store.standardbio.com/product_detail/guest-catalog/9100010" class="secondary-btn">Learn more</a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="-anchor" class="py-5 "> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <h2><span class="color-secondary-blue">Add compatible panels for deeper insights</span></h2> <hr /> <p>Capture a more complete view of neurodegeneration by combining any neurodegeneration panel with human immuno-oncology IMC subpanels, the <a href="https://store.standardbio.com/product_detail/featured-flow/201337">Maxpar Neuro Phenotyping IMC Panel </a>Kit, the <a href="https://store.standardbio.com/product_detail/featured-flow/201500">Maxpar IMC Cell Segmentation Kit </a>and Cell-ID™ Intercalator. </p> <p>View the <a href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u000000dmji/2LL2CP_B5SXcCvpu4j_2HVX406S2YeBMDmMp4sr7lDM" target="_blank">application note</a> to see how three different high parameter 41-marker panels for neurodegenerative disease can be easily assembled, with a particular focus on insights from Alzheimer’s disease tissue.</p> <p><a class="primary-btn-purple" href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u000000dmji/2LL2CP_B5SXcCvpu4j_2HVX406S2YeBMDmMp4sr7lDM" target="_blank">View Application note</a></p> <p> </p> </div> </div> </div> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <p><img src="/FluidigmSite_Assets/PrdSrv-Tech_ImagingMassCytometry/Images/image-thumb__14564__auto_784669853e28a123c3e33aff59355983/IMC_Neuroscience_HumanIOplus-neurodegenration-panels.jpg" style="width: 100%;" /></p> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_featurette pimcore_area_content "> <div id="customer-stories-anchor" class="featurette-circle bg-grad-blue color-white position-relative py-4 py-lg-5 "> <img class="featurette-image" src="/static/fluidigm/img/featurette-circle-bg.png" alt="background pattern"> <div class="container pt-2 pb-4 position-relative"> <div class="row "> <div class="d-none d-lg-block col-lg-1"></div> <div class="d-flex px-5 py-3 p-lg-0 col-12 col-lg-3 justify-content-center align-items-center"> <picture data-alt="Daniela Quail, PhD" data-default-src="/FluidigmSite_Assets/Generic-Assets/Images/Speaker-Headshots/image-thumb__12896__medium-circle/Headshot_Daniela-Quail_BW_Circle.png"> <source srcset="/FluidigmSite_Assets/Generic-Assets/Images/Speaker-Headshots/image-thumb__12896__medium-circle/Headshot_Daniela-Quail_BW_Circle.png 1x, /FluidigmSite_Assets/Generic-Assets/Images/Speaker-Headshots/image-thumb__12896__medium-circle/Headshot_Daniela-Quail_BW_Circle@2x.png 2x" type="image/png" /> <img title="Daniela Quail, PhD" class="img-fluid circle-image" alt="Daniela Quail, PhD" src="/FluidigmSite_Assets/Generic-Assets/Images/Speaker-Headshots/image-thumb__12896__medium-circle/Headshot_Daniela-Quail_BW_Circle.png" /> </picture> </div> <div class="d-none d-lg-block col-lg-3"></div> <div class="col-12 col-lg-4 d-flex flex-column justify-content-center orange-list-items"> <h3>Webinar: Spatial Dissection Of Tumor Immune Microenvironment</h3> <p><strong>Daniela Quail, PhD</strong><br /> Assistant Professor, Rosalind and Morris Goodman Cancer Institute and Department of Physiology, McGill University</p> <p>Quail describes the use of Imaging Mass Cytometry to understand immune dynamics in tumors – first in the brain tumor microenvironment to identify new cell populations that might help understand tumor biology and second in non-small-cell lung cancer patients to predict recurrence and survival outcomes.</p> <div class="primary-btn-alt mt-3"> <a href="https://standard-biotools.wistia.com/medias/r2xvjclzsn" target="_blank" title="Watch webinar" class="align-self-start" type="internal">Watch webinar</a> </div> </div> <div class="d-none d-lg-block col-lg-1"></div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="posters-anchor" class="py-5 "> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <h2 class="color-secondary-blue p-4">Posters</h2> <div class="container"> <div class="row g-4"> <div class="col-lg-3 col-sm-12"> <div class="h-100 bg-grad-blue p-4" style="display:flex; 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