CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "www.science.org",cType: 'managed',cRay: '8e8d92c10b755feb',cH: 'nXRivlKmS5wTI7RXfqBwcnRLAnVVmInodKIdPlpZe18-1732662850-1.2.1.1-gYSRw.tRV_67SLL.Rc9DCcsw10rHlkAX.gBddnpA2pzEll1hKTAAdbB79ehPKIBY',cUPMDTk: "\/doi\/abs\/10.1126\/science.aau5324?__cf_chl_tk=0_wDQXBeZyQTzyxRf0oWqcbRhb9vOZojSsMFccoILLY-1732662850-1.0.1.1-8N9r4Rk6PhdzxLXdZwxvlxdUEsOVsNO9IYKkomNJGhE",cFPWv: 'b',cITimeS: '1732662850',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/abs\/10.1126\/science.aau5324?__cf_chl_f_tk=0_wDQXBeZyQTzyxRf0oWqcbRhb9vOZojSsMFccoILLY-1732662850-1.0.1.1-8N9r4Rk6PhdzxLXdZwxvlxdUEsOVsNO9IYKkomNJGhE",md: "nneDfdnIle8hcTJ4.ZmZO.NDyC5K5HcqPEDWyqeyn_A-1732662850-1.2.1.1-pzDgNggu9H73n6S6S8QOD6.fJsu9IQnq0rwUpEXg2IDgU3UH0TIRytJIRQWlB8Cp7RcmazeeKSoRr1veRpiyEjH9X5Tb3QPgsHmut_Uj4w9w47bsHYjFPsbIPjHnNa6.3VaLa0MfWdqJ4xFiGQhYGWqmsFEQKa_Qm4vl1rSpEBEjVQZt2N6juxm8CO5zM.zeGz7ulxgqv.2ItzjKvdrTE4xe8xZDWX5z.6YWMZd0ZUo27ciZ1FYbbzRGDc98XWK1pNW35ErG3lruKblQucXruu.sw7e_WdqjjB6QDKYFsgf5Dr7Zka4JSJAPy0gTKwahiZwdxr4JvR15FHDaeoSnkInJxArckTJEA5nBw02PS0dmuDb8.4YdM9pr8qw8EdT1e7PPFZtrDfaOlzxenItQMMijQZjxZX04kyOdwAb_tztD7UuEbfdaocBObO_v_tPKDJqutpdDOWwLOi26tGMkCpEbPIKcv7XKLJlGbP3tKiEUQ64Kwpwy9xKQ1MB1h71pBfiZWrgLOGHgNa9zcOliVWp0wYzwivljxWev45bUTsGK6dmr7.Wik_NSBP4O0qd7VdTKM_FfELQDi4xWNCOM6N4D._7nHFYfcn5ItGL20cRpflwoIyKWswkPQ4klVu0ZjeVMS8lwMqpQNWTDp0wrCC3NywJ2uSLwby8ga0iaFlClxPZi4zQbDvq6Udc3kvq342jyxnQUWLmE2rUJ6FnmJuf9myaq9.Jl7yXopwenyrP0ziuhgeKH_XiKs.e3HqlQLlFT0elSyLQngkfm40nE3zv5Sr4Yb1f97.TWF7Gz3igXkzBm2kT1.WKTbzokLOa5iOJVI0S6oyOcpFDyOZiiS.oLe.892oFN4wjdRuGdwplImrWCYEuAOEy761EfBqKYnHgGRHce0RNoqQIVrQqXke9f2evYqkJLIfEfhKF8hwAEODMU6Br_TgEXZt5wiWF844e4QJ11y46e3Z9VU5sVo.Bi6303udOcPE3Ut04to8oL1G9lTHIUjmlfl36bxfGWR.Rt7kkSnsnM0LZJPmQ9IqrVxCCUuwGR1V8DHffoDxQPAeHHbU2CP_BecP0rIdYTtMMQ7Ob_0qGU5Z_XzQmWwccRXpAL6CM8Q5o7LAf.Lw4SFIonfStiXKe1m4JbXkr0BeUreBTtNq9Png0pRwvlVjiXnBXzkC3KUlhIoq3HqN6Zl86SI425BE_cmxryxe0xXZEImnKR5YBZUS56AtQDPO3rzrIE3ph3_1WYbBwsXLVIeq01VS1xYob8mMStTzMT2e9KIJURAlHO8wWQrZZW5kosxRhTf4cMc5c6if6tpIqlPx0Ka82vdufTxO.9YM032ANcbflcQXBmX_tth2s6O8ah7ke1ofLRe_vJAOeJxnXXDHaCPZMgAXWXT5Ae0UOxKjjNBsHa.Ovmo249b5FntmuPqPY0obivQyhQAb0bPn8EOnhyql0DNO6A_vKgS0CPmudqgDDmhQJTHmDedFsUAQ2PTVdWA6j3F4NLH8VHHagufdDVsMSj.XFwX.SV9EFvGhi82lW.uKZ4C9Ty1t7B9sSSRkbQYh4tXbEByn.OVyIHhQfGKZBsKJZgbD1soSL.phmcwCnbtFthWe2lxqbeB5ubEaSLHXSESgyIKfZWEr3M2VWCCaiZGMulPa58fbWyijwUWxYvEssNskTnau8Kn0uqBNTInGS6aVjeWDDciDJW96LLj58IMazx4xIdhYTKreUR1wC9yta5vQyvsm7nMOy_Vs6_K63keqDcPwVTIV0iPtQSi4pZxV2FVqRUUDk_moL8ooKBFlmYe5k1kkDERZjSN9.JU5lTcHHSCwjCMN1Fnw._iG0dCNIi9kD00fTb53Uz6RX0mp6qAtQv1vand1B4DXTbOKvO.DEJmxsL09sZCCqpwxGFlMcty1OS9xLbWVld7Es8b8BFtk6um4A7OIbx7C_PVWR9COCakDgwBtqHd7unKkz9AnhakFgP1Ch0eHLgx0xT8_kCCccI5.xwT7TBmOTIizJm0lZ3rM3ROFVqOT.xqOl45sWx0VOT8J1dN3VkA5DOMTBfUZu1X0RoMaQDCX_ujYgUtml79fUQweCHo_ICnr3U7CeejK0eMZrzVa7PxnHjaNRmo.n_011nr62gtvlH4K5jTe2l7CIVfAWI0HLZcMdkJRdkI8QXXx6yrha20uSfUIQQGwDffEvHqEZykww4pRlcaocaBIgxCuNTUAXKnHTKmK7.6PNUAFE.dc1iyOQAe_4OvSqWK6CWapzXUCnv_7O2AMhz7zXDNHSWLJtma8b4CJER8jgjA89ZqVwdWOTZ1I8tRW3gdXnmhnxiWHdbivOaE2SdHxw6XXanR3GXoODav3hHgRPV5_tARwMNbDuJXeyQT.FE76epiIeDHjFynNqBj.KRc1Kipv45ggvfdGsp.OmnrPo0FP7EFYPGz_AG_J.DZQvvgn5FFluKPfupQmIfS3Zv4luo3nNH.o.oTT9xWw71ZWpGLUMp6cSKmM1prFqnG5CVlDYQSYtLsuh7mcBVsYcee4uxAl0OMNANyFEw49_5jNCOhGgaKp39wycf5tVW273hwQ1bh.BlBNh78eepDoz09sMXmAfG8thWRMZvrCvVAFzb.qZRSGD7Q6nfKSKmKFr1XHju6rCH2qtUSOC6SpS04DHYmyFGiXfHWRxEfVmAFzTr4rQEOmPPJCfUscs5qGL3idSl3xRhy0eZ4m6eP8ptNPjYXvWp_CVgZ07wXmj._nfQr498B8pfzKp1W9HcJc_nEfMJOP1wJSLLnNCBojPMUMApEUijTMQdcWsKwsPJmbkW.DD2ytb8p_kZGEzQ8zFOg5QY7HVCQDXumA.rIJ.m2.DwBg4amUQ2Ms_MT871kbSOcibo_WsjmbBobrhuawgDOlsSo7uVuq2IvkMXuRHJDdh46Lz0JOMrYYaDSEqFS.pihboBTePDrAJ9HShrwV6PEL.g1ZdOP080JjJ0rwpGsTeH9JcAH35lFEEOpZSCftCcb.pw",mdrd: "aWQ_0enU.EAouI81hlR3nhKAtuOVX0lM2op4PfCVG.w-1732662850-1.2.1.1-zU83nqcUosxg8khGQ8Xt1Iq.bSaH7jeCT0kiYFXPjRaH7N1WJ8vqCDU48rFDVSzsugJs_I_ifckH0OE.S_d7sAzEiawNMtnMFPV1r0qGG3NmruavqLFsJlATeiMbuZFJi9sY74b04yyzcyAXp81haWMOw2BcECQjbz42whVp_o2k2UKd0hcWqi4520397pmB05KWy2NEYyjPZFJV4gvYQwzNng_rTUMPSrTx6q6dtnz76MxXfrHtWjI8Hwj5Mx3NFAmp8QcCBl7IiFOxjlp84mtvRUwRry2VVSbfZhTkCFaF9tpMYbcnoXAwr1qEfZSeHbBMEsPvdZwM1U8omRwR0FqqbtUyb1PjpEQA0PzWParAAqnxgR4sqxeeEnqoOgC9gNlLu_ERccbHkXscQIfP_o4.rrX.lx4Z_J1qYYRWMfjEH_DlNA2exV7xmnxSuXzthEwj4n9SJaeovf5Wpgcn55apyTLGJmka0al5XixY6nEXCzqU54CNS4ZgIlzLy2.glYdmNAr0605u5hDoyhvQAqVsB31pPOwiZH8E5pdt3JVr9Mn04usybmBICUYIs_TmVzOfCYbeEZiZ3MkMicjW7h81Gv3AO.6.PGJO2AofB6Uimro40EIgW28bRY6rURmE30IG4AJD.1wnGqMwcD5PPxyAQkG7A7hIicYwVpbsxOjTmIDu8tdCdwBpc2gC3YssrPn29GTbFqYoQYGy.G29F_lvrOD4grPp63qajj7To9OEuFBM5tW9XS.WtOxDkdbmgaNZ1BUBgBKlZh.iME4RB_x.ZKnpBY0MeIv._5iIPXh3V1usQYh4qqRyBpsshulg2Eh00FOPmlW3pak44CQgaiA8254YYh22EmZv_19alGAgMnrpglIDIUwwBckWdWYFo1eRGCLZ5NZQOqauXODLvBNnNfoIUqOWlnXyWNNgjy5XRytrucNNQ1SmJuy8s9iBxjqWwkYyNPHOdpbpgOodCKHl3eG6dV3RRTGh.StJGgvTgbBL0k5AkkKdTqWjleFM.W2AfR3eSxmbaJNJPhwodR2NxyLmWla98.afawPgkHjJdwcESeh3XBey8lYyzj_XcBWuJ5CeRDMFRQbdqEh8wvMgmD_XcXoBWkKFiCiGQjAeCPM3FFciMhs5v7Zn0r02UF.44FceHM_UTnSml6DHyH6v4Q_B1YWtGXN0iMkgFLdS.fWG2mVOrjnkwsHws4ol7lHnO255GWNdkljH_h3HkMs4lGDNTo0jZ_KTbiooBy_dRhF8crlLRDpy9EjP06p5AAuUNhAGR3egN.u21uaVdtT1EAWV.r3bXmDKJ2Gy5wA2re90BGW3dnOikytrpiziCHTs686c1YbMoqqSeMOv9tAkp_Dpgk2T2Qf3jBXQCfDVBchbJssOciBlB1Dt1uz9AqfIJ.F8sFOzIOL4KlPlTtjIhTgBr7b.HNyHjkCDwKt0Ez.MuWCnj8ahttTDxK.F668heFq_WYqW7o9WcilL5ZFpZxzWFNsBoUF6X7pGQmViAYCWs49PhHY.WRNAosKuOBD0wlfkKP.264elyQg.WZpQR6fvcAggFQMAjmmL4ImA3EuhTUTDb02qEYULItrJAgWVsh7PQatPzgAngy8BBMmvG0v.MjMsPmmwkYsjjpDgRn8J.Wqz1LSxpTd5KBPPlvlAgFGpkGZ0Esr9DKxnNXl3nwYPbFMgISFeTZpKuCDdwuAgttXKhxRDSOHrSFTXfmSDwbWa.BRlIZylhau8AsB.DCYY.yzdjkVwoIIWao4DIqurP9BZF8tY.x2HtfycI5QtDelVzKfY.xAqdal8ZZZDiYxSO5RtlRBb7Bvz_Cu.wnYGKRO4q30HENZD1NRMoWmt22dA0HdnOrhZSAX5yqXS7fQtAqGwUr4zebTIV7i3jE3ezE95rqT.sYKZb4fhaQvOLcM51h2Rt8YMr_J_5_9V4yIvKApuik5LJ0po752gPpqhnvjIDaMM4.z.3iCrvZ_5gdPA9soKcHeoXyAf8w"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8e8d92c10b755feb';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/abs\/10.1126\/science.aau5324?__cf_chl_rt_tk=0_wDQXBeZyQTzyxRf0oWqcbRhb9vOZojSsMFccoILLY-1732662850-1.0.1.1-8N9r4Rk6PhdzxLXdZwxvlxdUEsOVsNO9IYKkomNJGhE" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>