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Increased cancer risk for kidney transplant recipients linked to Epstein-Barr virus | Penn Today
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class="site-nav-event__date">2/21</p> </div> <div class="site-nav-event__text"> <a class="site-nav-event__link" href="/events/building-your-sustainability-pathway-penn" tabindex="0"> <h3 class="site-nav-event__head"> <span>Building Your Sustainability Pathway at Penn</span> </h3> <div class="site-nav-event__img-container"> <img loading="lazy" src="/sites/default/files/styles/event_small/public/2024-11/P-101775-Master-V1-001.jpg?h=56d0ca2e&itok=ZdqnWplN" alt="People gathered at a greenhouse on Penn’s Farm during the harvest." /> </div> <div class="site-nav-event__dek"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field__items"> <div class="field__item">Career Services hosts an interactive session with campus partners for Penn graduate students looking to deepen their engagement with the sustainability field. Registration for this virtual event is required.</div> </div></div> <p class="site-nav-event__time">12:00 p.m. - 1:00 p.m.</p> <p class="site-nav-event__location">Virtual</p> </a> </div> </article> </div> <div class="site-nav__event"> <article class="site-nav__event-content"> <div class="site-nav-event__date-container"> <p class="site-nav-event__date">2/21</p> </div> <div class="site-nav-event__text"> <a class="site-nav-event__link" href="/events/managing-anxiety-during-uncertain-times" tabindex="0"> <h3 class="site-nav-event__head"> <span>Managing Anxiety During Uncertain Times</span> </h3> <div class="site-nav-event__img-container"> </div> <div class="site-nav-event__dek"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field__items"> <div class="field__item">Lily Brown, a renowned expert in mental health and anxiety management, leads this workshop for Penn employees to learn effective techniques to cope with stress and anxiety during uncertain times. This workshop is sponsored by the Division of Human Resources.</div> </div></div> <p class="site-nav-event__time">12:00 p.m. - 12:45 p.m.</p> <p class="site-nav-event__location">Virtual</p> </a> </div> </article> </div> <div class="site-nav__event"> <article class="site-nav__event-content"> <div class="site-nav-event__date-container"> <p class="site-nav-event__date">2/27</p> </div> <div class="site-nav-event__text"> <a class="site-nav-event__link" href="/events/ground-control" tabindex="0"> <h3 class="site-nav-event__head"> <span>Ground Control</span> </h3> <div class="site-nav-event__img-container"> <img loading="lazy" src="/sites/default/files/styles/event_small/public/2023-03/weitzman-awards-teaser.jpg?h=5c617e3a&itok=5DfMylcB" alt="Entrance the the Weitzman School and art structure in Weitzman Plaza." /> </div> <div class="site-nav-event__dek"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field__items"> <div class="field__item">The Weitzman School of Design welcomes Jeffrey S. Nesbit of the Tyler School of Art and Architecture at Temple University to discuss his research on urbanization, infrastructure, and the evolution of "technical lands."</div> </div></div> <p class="site-nav-event__time">6:30 p.m.</p> <p class="site-nav-event__location">Fisher Fine Arts Library, 220 S. 34th St.</p> </a> </div> </article> </div> <div class="site-nav__event"> <article class="site-nav__event-content"> <div class="site-nav-event__date-container"> <p class="site-nav-event__date">3/4</p> </div> <div class="site-nav-event__text"> <a class="site-nav-event__link" href="/events/songs-love-and-loss" tabindex="0"> <h3 class="site-nav-event__head"> <span>Songs of Love and Loss</span> </h3> <div class="site-nav-event__img-container"> <img loading="lazy" src="/sites/default/files/styles/event_small/public/2024-01/Museum.jpg?h=06ac0d8c&itok=zQJFhrO4" alt="Penn Museum exterior" /> </div> <div class="site-nav-event__dek"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field__items"> <div class="field__item">In collaboration with the Philadelphia Chamber Music Society, Penn Museum presents flutist Emi Ferguson and harpist Ashley Jackson for a conversation and musical demonstration, moderated by Assyriologist Paul Delnero. The conversation will explore the role of the flute and harp in Sumerian culture. </div> </div></div> <p class="site-nav-event__time">6:30 p.m. - 8:30 p.m.</p> <p class="site-nav-event__location">Penn Museum, 3260 South St.</p> </a> </div> </article> </div> </div> </div> <div class="menu__close-bar"> <button class="js-menu-toggle menu__close"> <span class="visually-hidden">Close</span> <svg class="menu__close-icon" xmlns="http://www.w3.org/2000/svg" width="25" height="25" viewBox="0 0 25 25"> <polygon fill="#000127" fill-rule="evenodd" points="40.712 455.057 51.114 465.459 49.459 467.114 39.057 456.712 28.655 467.112 27 465.457 37.402 455.057 27.002 444.655 28.658 443 39.057 453.402 49.459 443 51.114 444.655" transform="translate(-27 -443)" /> </svg> </button> </div> </div> <header class="header-condensed header-condensed--article"> <div class="menu__wrapper"> <div class="menu__content"> <button class="search-bar__open js-search-bar-toggle" name="Searchbar Toggle" title="Search"> <span 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virus</span> </h1> <h2 class="article__subhead"> Researchers suggest changes in kidney transplant care and monitoring. </h2> </div> </section> </div> <div class="article__content-wrapper"> <div class="article__content"> <section class="article__body"> <p class="p1">More than 90% of the adult population in the U.S. is or has been infected with Epstein-Barr virus (EBV). EBV is a highly contagious member of the herpes virus family, best known for causing infectious mononucleosis and for its association with several cancers and autoimmune diseases. Kidney transplant patients who’ve never been exposed to EBV but receive organs from a donor who carried the virus may develop a life-threatening post-transplant complication called lymphoproliferative disorder (PTLD), according to a new study from the <a href="https://www.med.upenn.edu/">Perelman School of Medicine</a>. An estimated 4-5% of adult kidney transplants—as many as 1,200 patients per year—could be at risk of the condition, in which the body’s immune system gets confused and immune cells can grow out of control and act like cancer. The findings are published in <a href="https://www.acpjournals.org/doi/10.7326/ANNALS-24-00165"><em><span class="s1">Annals of Internal Medicine</span></em></a><span class="s1">.</span></p><div data-entity-type="media" data-entity-uuid="91bc02a0-7c6a-4029-a26f-e881e1bf5d0e" data-embed-button="media_entity_embed" data-entity-embed-display="view_mode:media.left_align" data-entity-embed-display-settings="[]" data-langcode="en" class="embedded-entity"><figure class="img-container img-container--leftalign"> <img loading="lazy" src="/sites/default/files/2025-02/kidneys-teaser.jpg" alt="illustration of translucent human lower abdomen with illuminated kidneys."> <figcaption class="caption"> Image: iStock/peterschreiber.media </figcaption> </figure> </div> <p class="p1">In kidney transplant recipients who had not previously been infected with EBV, researchers found that 22% who received a kidney from a donor who previously was infected with EBV developed PTLD—a rare and aggressive form of cancer—within three years post-transplant. That cancer rate <span class="s1">is five to 10 times higher than previously estimated</span> for kidney recipients, based on national registry data. Additionally, recipients who did not have EBV and received kidneys from people who did have a prior exposure to EBV faced a higher risk of death; nearly one-third of those affected by PTLD passed away from it during the study period.</p><p class="p1">This research adds significantly to the overall understanding of the disease. While the risk of being diagnosed with PTLD following a kidney transplant is widely recognized, it has historically been studied in populations of children since the chances of adults having zero exposure to EBV is much lower compared to children.</p><p class="p1">“National registry data likely underestimates PTLD incidence due to incomplete reporting and errors in tracking whether organ donors and recipients have been exposed to viruses like EBV,” says the study’s lead author, <a href="https://www.pennmedicine.org/providers/profile/vishnu-potluri?utm_medium=referral&utm_campaign=penn-medicine&utm_term=vishnu-potluri&y_source=1_MjkyNTI0ODctNDgzLWxvY2F0aW9uLndlYnNpdGU%3D"><span class="s1">Vishnu Potluri</span></a><span class="s1">,</span> an assistant professor in the Renal Electrolyte and Hypertension Division at Penn. “Our research used comprehensive, high-quality data from two leading U.S. transplant centers, and revealed a much higher risk than previous data has suggested.”</p><p class="p1"><a href="https://www.pennmedicine.org/providers/profile/emily-blumberg"><span class="s1">Emily Blumberg</span></a><span class="s1">, </span>Penn’s director of transplant infectious diseases, emphasizes the importance of proactive strategies for patient care: “We need to rethink how we monitor patients for EBV infection and how we manage immunosuppression for these high-risk patients. This includes early and routine testing for EBV activity in the blood and exploring personalized adjustments to immunosuppressive therapy.”</p><p>This story is by Matt Toal. Read more at <a href="https://www.pennmedicine.org/news/news-releases/2025/february/higher-cancer-risk-for-kidney-transplant-recipients-linked-to-ebv">Penn Medicine News</a>.</p> </section> <aside class="article__authors"> <div class="author-credits"> <div class="author-credits__section"> <dt class="author-credits__dt"> <h4 class="author-credits__h">Credits</h4> </dt> <dl class="author-credits__dl"> <ul class="author-credits__list"> <li class="author-credits__list-item"> <span class="author-credits__text"> <span class="author-credits__nolink">From Penn Medicine News</span> </span> <span class="author-credits__title">Writer</span> </li> </ul> </dl> </div> <div class="author-credits__section"> <dt class="author-credits__dt"> <h4 class="author-credits__h">Date</h4> </dt> <dl class="author-credits__dl"> <span class="author-credits__text"> <div class="field field--name-field-date field--type-datetime field--label-hidden field__items"> <div class="field__item"><time datetime="2025-02-19T12:00:00Z">February 19, 2025</time> </div> </div></span> </dl> </div> <div class="author-credits__section"> <dt class="author-credits__dt"> <h4 class="author-credits__h">Subtopics</h4> </dt> <dl class="author-credits__dl"> <ul class="article__topics-list"> <li class="article__topics-list-item"> <a href="/subtopic/medicine" class="article__topics-link">Medicine</a>, </li> <li class="article__topics-list-item"> <a href="/subtopic/infectious-diseases" class="article__topics-link">Infectious Diseases</a> </li> </ul> </dl> </div> <div class="author-credits__section"> <dt class="author-credits__dt"> <h4 class="author-credits__h">Schools</h4> </dt> <dl class="author-credits__dl"> <ul class="article__topics-list"> <li class="article__topics-list-item"> <a href="/schools/perelman-school-medicine" class="article__topics-link">Perelman School of Medicine</a> </li> </ul> </dl> </div> <div class="author-credits__section"> <dt class="author-credits__dt"> <h4 class="author-credits__h">Share</h4> </dt> <dl class="author-credits__dl"> <ul class="article__social-list"> <li class="article__social-list-item"> <a href="https://www.facebook.com/sharer/sharer.php?u=https://penntoday.upenn.edu/news/penn-medicine-increased-cancer-risk-kidney-transplant-recipients-linked-epstein-barr-virus" title="Share - Facebook" class="article__social-link article__social-link--facebook">Facebook</a> </li> <li class="article__social-list-item"> <a href="https://www.linkedin.com/sharing/share-offsite/?url=https://penntoday.upenn.edu/news/penn-medicine-increased-cancer-risk-kidney-transplant-recipients-linked-epstein-barr-virus" title="Share - LinkedIn" class="article__social-link article__social-link--linkedin">LinkedIn</a> </li> </ul> </dl> </div> </div> </aside> </div> </div> </div> <div class="article__share-tool js-share-tool"> <ul class="article__social-list"> <li class="article__social-list-item"> <a href="https://www.facebook.com/sharer/sharer.php?u=https://penntoday.upenn.edu/news/penn-medicine-increased-cancer-risk-kidney-transplant-recipients-linked-epstein-barr-virus" title="Share - Facebook" class="article__social-link article__social-link--facebook">Facebook</a> </li> </ul> </div> </article> <section class="article__related"> <section class="related-feature"> <div><style> .related-feature__img { background-image: url('/sites/default/files/2025-01/Cr_%20Chaowu%20Li-17.jpg'); 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