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menu-item-has-children menu-item-4570"><a>mRNA</a> <ul class="sub-menu"> <li class="et_pb_menu_page_id-4390 menu-item menu-item-type-post_type menu-item-object-page menu-item-4571"><a href="https://exothera.world/nucleic-acids-therapeutics-development-solutions/">Service Overview</a></li> <li class="et_pb_menu_page_id-4428 menu-item menu-item-type-post_type menu-item-object-page menu-item-4575"><a href="https://exothera.world/nucleic-acids-therapeutics-development-solutions-gmp-manufacturing/">Ntensify<sup style="font-size: 8px;">TM</sup> Platform</a></li> <li class="et_pb_menu_page_id-5653 menu-item menu-item-type-post_type menu-item-object-page current-menu-item page_item page-item-5653 current_page_item menu-item-5720"><a href="https://exothera.world/fast-track-ruo-mrna/" aria-current="page">RUO mRNA</a></li> </ul> </li> <li class="et_pb_menu_page_id-3516 menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3516"><a>Viral vectors</a> <ul 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menu-item-object-custom menu-item-has-children menu-item-525"><a>About Us</a> <ul class="sub-menu"> <li class="et_pb_menu_page_id-205 menu-item menu-item-type-post_type menu-item-object-page menu-item-523"><a href="https://exothera.world/about-us/">Our Purpose</a></li> <li class="et_pb_menu_page_id-2982 menu-item menu-item-type-post_type menu-item-object-page menu-item-3061"><a href="https://exothera.world/about-us-our-management/">Our Management</a></li> </ul> </li> <li class="et_pb_menu_page_id-4519 menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-4519"><a href="https://exothera.world/facilities/">Facilities</a> <ul class="sub-menu"> <li class="et_pb_menu_page_id-303 menu-item menu-item-type-post_type menu-item-object-page menu-item-520"><a href="https://exothera.world/facilities/">Discover our facilities</a></li> <li class="et_pb_menu_page_id-4331 menu-item menu-item-type-post_type menu-item-object-page menu-item-5623"><a href="https://exothera.world/facilities/commercial-facility/">Commercial facility</a></li> </ul> </li> <li class="et_pb_menu_page_id-1983 menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-1983"><a>Resources</a> <ul class="sub-menu"> <li class="et_pb_menu_page_id-3771 menu-item menu-item-type-custom menu-item-object-custom menu-item-3771"><a href="https://exothera.world/resources/">Insights</a></li> <li class="et_pb_menu_page_id-1925 menu-item menu-item-type-post_type menu-item-object-page menu-item-1982"><a href="https://exothera.world/press-releases/">Press Releases</a></li> </ul> </li> <li class="et_pb_menu_page_id-1203 menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-1203"><a>Careers</a> <ul class="sub-menu"> <li class="et_pb_menu_page_id-718 menu-item menu-item-type-post_type menu-item-object-page menu-item-984"><a href="https://exothera.world/our-values/">Our Values</a></li> <li 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research use only (RUO) mRNA</b></h1></div> </div><div class="et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2><span style="color: #ffffff;"><b>Your future-proofed mRNA, delivered in just 4 weeks</b></span></h2></div> </div><div class="et_pb_button_module_wrapper et_pb_button_0_wrapper et_pb_button_alignment_right et_pb_module "> <a class="et_pb_button et_pb_button_0 et_pb_bg_layout_dark" href="#calltoaction">Get a Quote</a> </div> </div> </div> </div><div class="et_pb_section et_pb_section_2 exo_horizental_timeline et_section_regular" > <div class="et_pb_row et_pb_row_2 changing-order-row"> <div class="et_pb_column et_pb_column_1_2 et_pb_column_2 second-on-tablet et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_3 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p><span style="font-weight: 400;"></span></p> <p><span style="font-weight: 400;">We offer an expedited RUO mRNA synthesis service with a 4-week turnaround time from order placement to delivery. This fast-track service is ideal for projects with tight deadlines or when rapid access to mRNA is critical.</span></p> <p><span style="font-weight: 400;">Not only that, but the process is designed to ensure consistent, quality production at any scale. Our automated scale-out system provides a seamless transition from your research projects to clinical applications, enabling cost and time efficiency at every stage through optimal </span><i><span style="font-weight: 400;">in vitro</span></i><span style="font-weight: 400;"> transcription (IVT) that enhances quality over traditional methods.</span></p></div> </div><div class="et_pb_button_module_wrapper et_pb_button_1_wrapper et_pb_button_alignment_left et_pb_module "> <a class="et_pb_button et_pb_button_1 et_pb_bg_layout_light" href="https://exothera.world/contact/" target="_blank">Contact us to find out more about our RUO mRNA service</a> </div> </div><div class="et_pb_column et_pb_column_1_2 et_pb_column_3 second-on-tablet et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_image et_pb_image_0"> <span class="et_pb_image_wrap "><img fetchpriority="high" decoding="async" width="2560" height="1789" src="https://exothera.world/wp-content/uploads/2024/05/fast-track-ruo-mrna-1-scaled.jpg" alt="Exothera team members providing GMP manufacturing solutions for RNA therapeutics" title="fast-track-ruo-mrna (1)" srcset="https://exothera.world/wp-content/uploads/2024/05/fast-track-ruo-mrna-1-scaled.jpg 2560w, https://exothera.world/wp-content/uploads/2024/05/fast-track-ruo-mrna-1-1280x895.jpg 1280w, https://exothera.world/wp-content/uploads/2024/05/fast-track-ruo-mrna-1-980x685.jpg 980w, https://exothera.world/wp-content/uploads/2024/05/fast-track-ruo-mrna-1-480x335.jpg 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 2560px, 100vw" class="wp-image-5709" /></span> </div> </div> </div><div class="et_pb_row et_pb_row_3 changing-order-row"> <div class="et_pb_column et_pb_column_1_2 et_pb_column_4 second-on-tablet et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_image et_pb_image_1"> <span class="et_pb_image_wrap "><img decoding="async" width="855" height="641" src="https://exothera.world/wp-content/uploads/2022/07/How-standardized-viral-vector-platforms-can-drive-better-service-from-CDMOs.png" alt="Ntensify Midi for GMP manufacturing solutions for RNA therapeutics" title="How standardized viral vector platforms can drive better service from CDMOs" srcset="https://exothera.world/wp-content/uploads/2022/07/How-standardized-viral-vector-platforms-can-drive-better-service-from-CDMOs.png 855w, https://exothera.world/wp-content/uploads/2022/07/How-standardized-viral-vector-platforms-can-drive-better-service-from-CDMOs-480x360.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 855px, 100vw" class="wp-image-5252" /></span> </div> </div><div class="et_pb_column et_pb_column_1_2 et_pb_column_5 second-on-tablet et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_4 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2><b>Make a “smart start” to your RUO project: Utilize Exothera’s optimized process</b></h2></div> </div><div class="et_pb_module et_pb_text et_pb_text_5 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p><span style="font-weight: 400;">We offer a seamless transition from RUO to GMP for your mRNA manufacturing project. </span></p> <p><span style="font-weight: 400;">Our scale-out system is designed to:</span></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Deliver consistent, reliable and high-quality mRNA at any scale </span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Facilitate seamless transition from the screening base to production without scale-up</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Eliminate the need for costly and time-consuming process development</span></li> </ul> <p><span></span></p></div> </div> </div> </div><div class="et_pb_row et_pb_row_4 changing-order-row"> <div class="et_pb_column et_pb_column_1_2 et_pb_column_6 second-on-tablet et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_6 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2><span style="font-size: 34px;">Ntensify™</span></h2></div> </div><div class="et_pb_module et_pb_text et_pb_text_7 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p><span style="font-weight: 400;">Our automated Ntensify™</span><span style="font-weight: 400;"> system, supplied by sister company Quantoom Biosciences, ensures that the process always stays the same, regardless of quantity. This allows you to start with small quantities of RNA for internal screening use and seamlessly progress to GMP manufacturing without scaling up or worrying about changing reagents or processes.</span></p></div> </div> </div><div class="et_pb_column et_pb_column_1_2 et_pb_column_7 second-on-tablet et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_image et_pb_image_2"> <span class="et_pb_image_wrap "><img decoding="async" width="8192" height="5464" src="https://exothera.world/wp-content/uploads/2024/05/5B1A6761_OPT.jpeg" alt="Laboratory technician operating in one of the Exothera's cleanrooms" title="5B1A6761_OPT" srcset="https://exothera.world/wp-content/uploads/2024/05/5B1A6761_OPT.jpeg 8192w, https://exothera.world/wp-content/uploads/2024/05/5B1A6761_OPT-300x200.jpeg 300w, https://exothera.world/wp-content/uploads/2024/05/5B1A6761_OPT-1600x1067.jpeg 1600w, https://exothera.world/wp-content/uploads/2024/05/5B1A6761_OPT-768x512.jpeg 768w, https://exothera.world/wp-content/uploads/2024/05/5B1A6761_OPT-1536x1025.jpeg 1536w, https://exothera.world/wp-content/uploads/2024/05/5B1A6761_OPT-1080x720.jpeg 1080w" sizes="(max-width: 8192px) 100vw, 8192px" class="wp-image-5739" /></span> </div> </div> </div><div class="et_pb_row et_pb_row_5 changing-order-row"> <div class="et_pb_column et_pb_column_1_2 et_pb_column_8 second-on-tablet et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_image et_pb_image_3"> <span class="et_pb_image_wrap "><img decoding="async" width="1878" height="1410" src="https://exothera.world/wp-content/uploads/2022/03/Serum-based-media-concerns-in-viral-vector-manufacturing.png" alt="Ntensify Midi for GMP manufacturing solutions for RNA therapeutics" title="Serum-based media concerns in viral vector manufacturing" srcset="https://exothera.world/wp-content/uploads/2022/03/Serum-based-media-concerns-in-viral-vector-manufacturing.png 1878w, https://exothera.world/wp-content/uploads/2022/03/Serum-based-media-concerns-in-viral-vector-manufacturing-1280x961.png 1280w, https://exothera.world/wp-content/uploads/2022/03/Serum-based-media-concerns-in-viral-vector-manufacturing-980x736.png 980w, https://exothera.world/wp-content/uploads/2022/03/Serum-based-media-concerns-in-viral-vector-manufacturing-480x360.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 1878px, 100vw" class="wp-image-5250" /></span> </div> </div><div class="et_pb_column et_pb_column_1_2 et_pb_column_9 second-on-tablet et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_8 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2><b style="font-size: 30px;"></b></h2> <h2><b style="font-size: 30px;">Our mRNA analytical service</b></h2></div> </div><div class="et_pb_module et_pb_text et_pb_text_9 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><ul> <li><span style="font-weight: 400;">Plasmid DNA can either be provided by you or Exothera (plasmid supply not included in the timeline above)</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Exothera will use a co-transcriptional capping reagent for </span><i><span style="font-weight: 400;">in vitro</span></i><span style="font-weight: 400;"> transcription of 5’ capped mRNA resulting in a Cap1 structure </span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Purified mRNA eluted in nuclease-free water</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Typical concentration: 0.5 – 1mg/mL</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Analytical testing includes concentration, integrity and ID</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Additional mRNA testing services are available upon request</span></li> </ul> <p><span></span></p></div> </div><div class="et_pb_button_module_wrapper et_pb_button_2_wrapper et_pb_button_alignment_left et_pb_module "> <a class="et_pb_button et_pb_button_2 et_pb_bg_layout_light" href="https://exothera.world/nucleic-acids-therapeutics-development-solutions-analytical/" target="_blank">Learn more about our analytical services</a> </div> </div> </div><div class="et_pb_row et_pb_row_6"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_10 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_divider_0 et_pb_space et_pb_divider_hidden"><div class="et_pb_divider_internal"></div></div> </div> </div><div id="calltoaction" class="et_pb_row et_pb_row_7"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_11 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module 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