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Three simultaneous studies in the journal Nature lay all the cards on the table, revealing ecDNAs’ content, their origin, their inheritance, their influence in cancer, and a way to combat them." /> <meta property="og:author" content="Mar de Miguel" /> <meta property="og:url" content="https://www.bioworld.com/articles/714423-extrachromosomal-dna-acts-as-joker-for-cancer-cells" /> <meta property="og:image" content="https://www.bioworld.com/ext/resources/BWS/BWS-source/stanford-ecdna-11-11.jpg?height=635&t=1731345576&width=1200" /> <meta property="og:image:width" content="846" /> <meta property="og:image:height" content="635" /> <meta property="og:type" content="Article" /> <meta name="twitter:title" content="Extrachromosomal DNA acts as joker for cancer cells " /> <meta name="twitter:description" content="Cancer therapies can eliminate specific tumors based on their genetic content. However, some cancer cells survive. How do they do it? 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Link to Cortellis page on Clarivate website." loading="lazy" src="/images/Cortellis_Flagship_Logo_TM_RGB_Color.png" /></div><h1 class="intent-popup__headline">Upgrade your daily dose of biopharma and medtech news</h1><h2 class="intent-popup__sub-headline"></h2><div class="intent-popup__content"> <p>Subscribe to BioWorld™ news services</p> </div><a class="intent-popup__link" href="https://www.bioworld.com/orders?utm_campaign=BioWorld_LS_Global_2021&utm_source=popup_banner&utm_medium=owned">See subscription options</a></div><div class="intent-popup__bg"></div></section><script>function setLocalExp(key, value, ttl) { var now = new Date() // `item` is an object which contains the original value // as well as the time when it's supposed to expire var item = { value: value, expiry: now.getTime() + ttl, } localStorage.setItem(key, JSON.stringify(item)) } function getLocalExp(key) { var itemStr = localStorage.getItem(key) // if the item doesn't exist, return null if (!itemStr) { return null } var item = JSON.parse(itemStr) var now = new Date() // compare the expiry time of the item with the current time if (now.getTime() > item.expiry) { // If the item is expired, delete the item from storage // and return null localStorage.removeItem(key) return null } return item.value } var intentStatus = getLocalExp('intent-popup'); if (intentStatus != 'true') { $('.intent-popup').show(); $('.intent-popup__close, .intent-popup__bg').click( function() { $('.intent-popup').hide(); setLocalExp('intent-popup', 'true', 86400000); }); }</script><div class="box1 article article-preview"><div id="subscribeBannerLarge">To read the full story, <a href="/subscriptions">subscribe</a> or <a href="/user/login">sign in</a>.</div><h1 class="page-article-teaser__headline">Extrachromosomal DNA acts as joker for cancer cells </h1><div class="page-article-teaser__meta-container"> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 12, 2024</div> <div class="author article-summary__author">By <a href="/authors/595-mar-de-miguel">Mar de Miguel</a></div> <div class="comment-count article-summary__comment-count"><a title="Extrachromosomal DNA acts as joker for cancer cells " class="more" href="https://www.bioworld.com/articles/714423-extrachromosomal-dna-acts-as-joker-for-cancer-cells#comments-container">No Comments</a></div> </div></div><div class="page-article-teaser__content">Cancer therapies can eliminate specific tumors based on their genetic content. However, some cancer cells survive. How do they do it? Part of the answer lies in extrachromosomal DNA (ecDNA), an ace up the tumors’ sleeve to adapt and evade attack. Three simultaneous studies in the journal <em>Nature</em> lay all the cards on the table, revealing ecDNAs’ content, their origin, their inheritance, their influence in cancer, and a way to combat them.</div><span class="topics"><a class="topic" href="/topics/84-bioworld">BioWorld</a><span class="del"> </span><a class="topic" href="/topics/110-science">Science</a><span class="del"> </span><a class="topic" href="/topics/117-drug-resistance">Drug resistance</a><span class="del"> </span><a class="topic" href="/topics/239-cancer">Cancer</a><span class="del"> </span><a class="topic" href="/topics/548-genetic-congenital">Genetic/congenital</a></span></div></div><aside class="main-interior-sidebar"><div class="main-interior-sidebar__column"><div id="article-recommendations"></div> </div><div class="main-interior-sidebar__column"><section class="popular-stories "> <h1 class="popular-stories__title">Popular Stories</h1><ul class="popular-stories__items"> <li class="popular-stories__item"> <article class="popular-stories__article popular-stories--article"><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/432891-todays-news-in-brief">Today's news in brief</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/84-bioworld">BioWorld</a></div><div class="popular-stories__teaser"><em>BioWorld</em> briefs for Nov. 22, 2024.</div></div></article> </li> <li class="popular-stories__item"> <article class="popular-stories__article popular-stories--article"><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/699574-todays-news-in-brief">Today's news in brief</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/85-bioworld-medtech">BioWorld MedTech</a></div><div class="popular-stories__teaser"><em>BioWorld MedTech</em> briefs for November 21, 2024.</div></div></article> </li> <li class="popular-stories__item"> <article class="popular-stories__article -has-image popular-stories--article"><figure class="popular-stories__image"><a class="popular-stories__thumbnail-link" data-eventname="popular-stories" data-eventcategory="click" data-eventaction="popular-stories-image" data-eventlabel="https://www.bioworld.com/articles/714048-j-and-js-ottava-robotic-system-approved-for-us-pivotal-trial" href="https://www.bioworld.com/articles/714048-j-and-js-ottava-robotic-system-approved-for-us-pivotal-trial"><img class="popular-stories__image-thumb" alt="Da Vinci Xi robot - Intuitive Surgical" title="Da Vinci Xi robot - Intuitive Surgical" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BMT-source/2023/1-26--Da-Vinci-Xi-robot-Intuitive-Surgical.png?height=355&t=1699482891&width=640" /></a></figure><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/714048-j-and-js-ottava-robotic-system-approved-for-us-pivotal-trial">J&J’s Ottava robotic system approved for US pivotal trial</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/85-bioworld-medtech">BioWorld MedTech</a></div><div class="popular-stories__teaser">Johnson & Johnson received U.S. FDA investigational device exemption to begin the pivotal clinical trial for the Ottava robotic surgical system. 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