Science/AAAS | Science Signaling: Signal Transduction Knowledge Environment

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Articles</a></li> </ul> </div> </div> <div class="Promo" id="navgroup_sponsor-logos"> <div class="Item">  <script language="JavaScript">  </script>   <script language="JavaScript">  </script>  </div> </div> </div>  <hr/> </td> <td id="MainColumnCell">  <div id="MainColumn"> <a id="ContentTop" name="ContentTop"></a> <h2>In the Current Issue <span><a href="/web/20110710223213/http://stke.sciencemag.org/content/vol4/issue180">5 July 2011 (Issue 180)</a></span></h2> <table border="0" cellspacing="0" cellpadding="0" class="LayoutTable"> <col width="195"> <col width=""> <tr> <td class="LeftColCell"> <div id="current-issue-photo"> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/content/vol4/issue180"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/4180home.gif" width="175" height="210" border="0" alt="Lysosomes regulate glucocorticoid signaling"></a> <p>Lysosomes regulate glucocorticoid signaling</p> <ul class="LinkList"> <li><a href="/web/20110710223213/http://stke.sciencemag.org/content/vol4/issue180/cover.dtl">Image details</a></li> <li><a href="/web/20110710223213/http://stke.sciencemag.org/content/vol4/issue180/">Current Issue Table of Contents</a></li>  </ul> </div> <p><b>Learn about the Print Edition</b> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/about/Print_Compilation.dtl"><img src="https://web.archive.org/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/Print_Online2.jpeg" alt="Print Edition"/></a></p></div>  </div> <p></p>  <br> <div class="Item" id="stke_alert" style="margin-bottom:0px;"> <div class="BorderFix"> <h3><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/NewDataCellSig.gif" alt="The Database of Cell Signaling" width="152" height="30" border="0"></h3> <p>Featured Connections Map:<br/> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/cm/stkecm;CMP_20386">Hedgehog Signaling Pathway in <em>Drosophila</em></a></p> <p class="Exception"><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cm/">Browse all Pathways »</a></p> </div> </div> </td> <td class="RightColCell"> <div class="Item" id="stke_research"> <h3>Research Articles</h3> <p> <dl> <dt style="margin-top: 0pt; padding-top: 0pt;">Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog</dt> <dd>Ying Su, Jason K. Ospina, Junzheng Zhang, Andrew P. Michelson, Adam M. Schoen, and Alan Jian Zhu<br> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/summary/sigtrans;4/180/ra43" title="View the Editor's Summary for this article">Editor's Summary</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/180/ra43" title="View the Abstract for this article">Abstract</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/sigtrans;4/180/ra43" title="View the Full Text for this article">Full Text</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/reprint/sigtrans;4/180/ra43.pdf" title="View the PDF for this article">PDF</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/sigtrans;4/180/ra43/DC1" title="View the Supplementary Materials for this article">Supplementary Materials</a> </dd> </dl> </p> <p> <dl> <dt style="margin-top: 0pt; padding-top: 0pt;">Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response</dt> <dd>Yuanzheng He, Yong Xu, Chenghai Zhang, Xiang Gao, Karl J. Dykema, Katie R. Martin, Jiyuan Ke, Eric A. Hudson, Sok Kean Khoo, James H. Resau, Arthur S. Alberts, Jeffrey P. MacKeigan, Kyle A. Furge, and H. Eric Xu<br> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/summary/sigtrans;4/180/ra44" title="View the Editor's Summary for this article">Editor's Summary</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/180/ra44" title="View the Abstract for this article">Abstract</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/sigtrans;4/180/ra44" title="View the Full Text for this article">Full Text</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/reprint/sigtrans;4/180/ra44.pdf" title="View the PDF for this article">PDF</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/sigtrans;4/180/ra44/DC1" title="View the Supplementary Materials for this article">Supplementary Materials</a> </dd> </dl> </p> </div> <div class="Item" id="stke_perspectives"> <h3>Perspective</h3> <p> <dl> <dt style="margin-top: 0pt; padding-top: 0pt;">Bacterial Scaffolds Assemble Novel Higher-Order Complexes to Reengineer Eukaryotic Cell Processes</dt> <dd>Cammie F. Lesser and John M. Leong <br> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/180/pe32" title="View the Abstract for this article">Abstract</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/sigtrans;4/180/pe32" title="View the Full Text for this article">Full Text</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/reprint/sigtrans;4/180/pe32.pdf" title="View the PDF for this article">PDF</a> </dd> </dl> </p> </div> <div class="Item" id="Podcast"> <h3>Podcast</h3> <p> <dl> <dt style="margin-top: 0pt; padding-top: 0pt;"> <em>Science Signaling</em> Podcast: 5 July 2011</dt> <dd>Yuanzheng He and Annalisa M. VanHook<br> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/180/pc13" title="View the Abstract for this article">Abstract</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/sigtrans;4/180/pc13" title="View the Full Text for this article">Full Text</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/sigtrans;4/180/pc13/DC1" target="podcast_audio">Podcast</a> </dd> </dl> </p> </div> <div class="Item" id="stke_editors_choice">  <h3>Editors' Choice</h3> <p> <dl> <dt style="margin-top: 0pt; padding-top: 0pt;">Evading Death</dt> <dd>A. F. Swindall, S. L. Bellis, <em>J. Biol. Chem.</em> <b>286</b>, 22982–22990 (2011).</dd> <dd><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/abstract/4/180/ec184">Read this Summary</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/content/vol4/issue180/#STKE_EDITORS__CHOICE">Read all Summaries</a> </dd> </dl> </p> </div> </td> </tr> </table> <div class="Item" id="stke_in-literature"> <h3><span>In Literature</span></h3> <dl> <dt>What's Hot</dt> <dd>Read this highly accessed article published recently in a previous issue: <br/> <b>Mechanism of Impaired NLRP3 Inflammasome Priming by Monophosphoryl Lipid A</b><br>  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/abstract/4/171/ra28" title="View the abstract of this article">Abstract</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/4/171/ra28" title="View the full text of this article">Full Text</a> </dd> <dt>Virtual Journal</dt>  <dd>Check out this article, just added to the Virtual Journal: <br/> <b>Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair</b><br><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/abstract/sci;333/6038/84">Abstract</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/content/full/sci;333/6038/84">Full Text</a>  |  <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/literature/vj/">Search and browse the Virtual Journal</a></dd> <dt>Related to <i>Science</i></dt> <dd>Find <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/about/scirelated/2011.dtl">articles and resources</a> that complement special issues or particular articles in <em>Science</em>.</dd> <dt>Featured in <i>Science</i></dt> <dd>Find <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/about/scifeatured/2011.dtl"><i>Science Signaling</i> articles</a> featured in the Editors' Choice section of <em>Science</em> Magazine.</dd> <dt><i>Science Signaling</i> Preview</dt> <dd>Get an advanced peek at <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/literature/preview/">abstracts</a> of upcoming <i>Science Signaling</i> articles.</dd> <dt>Issue Archive</dt> <dd>Access the <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/archive/">table of contents</a> of back issues of <em>Science Signaling</em> (a continuation of <em>Science</em>'s <em>STKE</em>). </dd> </dl> </div> <div class="Item" id="stke_in-community"> <h3><span>In Community</span></h3> <dl> <dt><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/calendarcontent"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/Events44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>Events, Meeting Reports, and Presentations </dt> <dd>Check out the <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/calendarcontent/">calendar</a>, read <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/search?SITESECTION=meeting_reports&hits=10&fulltext=&searchtemplate=recent_issues_archive搂ion=STKE+Meeting+Reports&fullsection=Meeting+Reports">highlights</a>, and view <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/search?SITESECTION=presentations&hits=10&fulltext=&searchtemplate=recent_issues_archive搂ion=STKE+Presentations&fullsection=Presentations">presentations</a> of cell signaling meetings and conferences.</dd> <dt><a href="/web/20110710223213/http://stke.sciencemag.org/cgi/wpBrowse"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/Directory44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>Directory</dt> <dd>Featured person: <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/wpContent/stkewp;PERSON_1034">M. Blumenberg</a>. Find collaborators and people with shared research interests—join the Signaling community and add your information to the <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/wpBrowse">Directory</a>!</dd> <dt><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/forum"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/Forums44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>Forums</dt> <dd> Share highlights from signaling meetings or read the recent posting "Katsuhiko Mikoshiba Honored by Karolinska Institutet" in the <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/forum-display/short/stke_el;648">Open Forum on Cell Signaling</a>. </dd> <dt><a href="/web/20110710223213/http://stke.sciencemag.org/cgi/eletters?lookup=by_date&days=3000"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/E-letters44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>E-Letters</dt> <dd>Featured E-Letter: <a href="/web/20110710223213/http://stke.sciencemag.org/cgi/eletters/sigtrans;2/87/ra51"> Early Stage Investigator Award</a>. Find out <a href="/web/20110710223213/http://stke.sciencemag.org/about/help/eletters.dtl">how to submit a comment</a> to make <i>Science Signaling</i> a rich community by contributing your knowledge. For example, share your experiences with a method described in a Protocol; tell other teachers how you used Teaching Resources; alert the community to research related to those highlighted in Editors' Choice; comment on or ask the authors about their articles. </dd> </dl> </div> <div class="Item" id="stke_in-resources"> <h3><span>In Resources</span></h3> <dl> <dt><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/search?SITESECTION=education&hits=10&fulltext=&searchtemplate=recent_issues_archive搂ion=STKE%20Teaching+Resources&fullsection=Teaching+Resources"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/TeachingResources44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>Teaching Resources</dt> <dd>More than 50 different <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/search?SITESECTION=education&hits=10&fulltext=&searchtemplate=recent_issues_archive搂ion=STKE%20Teaching+Resources&fullsection=Teaching+Resources">resources</a> provide information for course planning, lecture notes, slides, and animations.</dd> <dt><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/glossarylookup"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/Glossary44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>Glossary</dt> <dd>Find out what those acronyms and abbreviations mean. Browse or search the <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/glossarylookup">glossary</a> of cell signaling terms. Look at the <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/resources/glossary/update_list.dtl">list of the most recently added terms</a>.</dd> <dt><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/search?SITESECTION=podcasts&hits=10&fulltext=&searchtemplate=recent_issues_archive搂ion=STKE+Podcasts&fullsection=Podcasts"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/signalingpodcast.jpg" alt="" width="44" height="44" border="0" class="Bullet"></a>Podcasts</dt> <dd>Tune-in for a portable and understandable summary of selected cell signaling research. Check out each episode of the <i>Science Signaling</i> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/search?SITESECTION=podcasts&hits=10&fulltext=&searchtemplate=recent_issues_archive搂ion=STKE%20Podcasts&fullsection=Podcasts">Podcast</a>.</dd> <dt><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/ul/sigtransUl;CAT_1"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/NetWatch44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>ST NetWatch</dt>  <dd>Featured in Awards and Announcements: <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/ul/sigtransUl;CAT_10#sigtransUl;WP_595">World Cell Race </a>. Explore the <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/ul/sigtransUl;CAT_1">sites</a> selected by the editors or <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/cgi/ul-submit">submit</a> your favorite signal transduction Web site.</dd> <dt><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/resources/funding/"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/Fundingsources44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>Funding Sources</dt> <dd>Check out the <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/resources/funding/">opportunities</a> for funding cell signaling research and training.</dd> <dt><a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/resources/jobs/"><img src="/web/20110710223213im_/http://stke.sciencemag.org/AAAS/images/page_icons/Jobs44.gif" alt="" width="44" height="44" border="0" class="Bullet"></a>Jobs</dt> <dd>Search or browse employment opportunities related to signal transduction in <i>Science</i> <a href="https://web.archive.org/web/20110710223213/http://stke.sciencemag.org/resources/jobs/">Careers</a>.</dd> </dl> </div> <div class="Item" id="stke_also-of-interest"> <h3><span>Also of Interest</span></h3> <ul class="DotBullet"> <li><a href="/web/20110710223213/http://stke.sciencemag.org/my_stke/">My <i>Science Signaling</i></a> provides tools for managing information and using <i>Science Signaling</i> resources more efficiently.</li> <li>Don't miss an issue, sign up for <i>Science Signaling</i> <a href="/web/20110710223213/http://stke.sciencemag.org/my_stke/e-alerts.dtl">eTOCs</a> today!</li> <li>Receive free <a href="https://web.archive.org/web/20110710223213/http://www.sciencemag.org/rss/">RSS feeds</a> of new articles and resources in <i>Science Signaling</i>. <a href="/web/20110710223213/http://stke.sciencemag.org/rss/current.xml"><img src="https://web.archive.org/web/20110710223213im_/http://www.sciencemag.org/icons/icon.xml2.gif" alt="XML" width="37" height="15" border="0" class="Icon"></a></li> <li><a href="https://web.archive.org/web/20110710223213/http://www.sciencemag.org/site/subscriptions/indiv_purchase.html">Register</a> for full access to many features of <i>Science Signaling</i>, including the Connections Maps database of cell signaling, the Teaching Resources, and more.</li> <li><a href="https://web.archive.org/web/20110710223213/http://promo.aaas.org/subscribesignaling/">Subscribe</a> today to take full advantage of the My <i>Science Signaling</i> tools and access the full text of <i>Science Signaling</i> original and Virtual Journal articles.</li> <li>Get more <a href="/web/20110710223213/http://stke.sciencemag.org/about/help/access.dtl">information</a> about access to <i>Science Signaling</i> articles, resources, and tools.</li> <li> Ask your librarian or site administrator about a site license to <i>Science Signaling</i> or use the <a href="https://web.archive.org/web/20110710223213/http://www.sciencemag.org/cgi/recommend_subscription">online form</a> to recommend a subscription to <i>Science Signaling</i> to your librarian today! 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