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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F105847677%2FPrediction_of_risk_of_COPD_exacerbations_by_the_BODE_index%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F105847677%2FPrediction_of_risk_of_COPD_exacerbations_by_the_BODE_index%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":105203240,"identifier":"Attachment_105203240","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":105847677,"created_at":"2023-08-22T06:52:08.922-07:00","from_world_paper_id":239114787,"updated_at":"2024-11-26T12:46:04.267-08:00","_data":{"publisher":"Elsevier BV","grobid_abstract":"This study assesses the power of the BODE index, a multidimensional grading system that predicts mortality, to predict subsequent exacerbations in patients with COPD. Design: Prospective cohort study. Patients and interventions: A total of 275 COPD patients were followed every 6 months up to 8 years (median of 5.1 years). Baseline clinical variables were recorded and the BODE index was calculated. We investigated the prognostic value of BODE quartiles (scores 0e2, 3e4, 5e6 and 7e10) for both the number and severity of exacerbations requiring ambulatory treatment, emergency room visit, or hospitalization. Results: The annual rate of COPD exacerbations was 1.95 (95% CI, 0.90e2.1). The mean time to a first exacerbation was inversely proportional to the worsening of the BODE quartiles (7.9 yrs, 5.7 yrs, 3.4 yrs and 1.3 yrs for BODE scores of 0e2, 3e4, 5e6 and 7e10, respectively). Similarly, the mean time to a first COPD emergency room visit was 6.7 yrs, 3.6 yrs, 2.0 yrs and 0.8 yrs for BODE quartiles (all p \u003c 0.05). Using ROC curves, the BODE index was a better predictor of exacerbation than the FEV 1 alone (p \u003c 0.01). Conclusions: The BODE index is a better predictor of the number and severity of exacerbations in COPD than FEV 1 alone.","publication_date":"2009,,","publication_name":"Respiratory Medicine","grobid_abstract_attachment_id":"105203240"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Prediction of risk of COPD exacerbations by the BODE index","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [276865887]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":105203240,"attachmentType":"pdf"}"><img alt="First page of “Prediction of risk of COPD exacerbations by the BODE index”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/105203240/mini_magick20230822-1-5t8uyr.png?1692712699" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Prediction of risk of COPD exacerbations by the BODE index</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="276865887" href="https://independent.academia.edu/CelliBartolome"><img alt="Profile image of Bartolome Celli" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/276865887/125913061/115283393/s65_bartolome.celli.jpeg" />Bartolome Celli</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2009, Respiratory Medicine</p></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":105203240,"attachmentType":"pdf","workUrl":"https://www.academia.edu/105847677/Prediction_of_risk_of_COPD_exacerbations_by_the_BODE_index"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":105203240,"attachmentType":"pdf","workUrl":"https://www.academia.edu/105847677/Prediction_of_risk_of_COPD_exacerbations_by_the_BODE_index"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="105203240" data-landing_url="https://www.academia.edu/105847677/Prediction_of_risk_of_COPD_exacerbations_by_the_BODE_index" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="36899557" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/36899557/BODE_Index_Vs_FEV1_In_Predicting_Outcome_And_Number_Of_Exacerbations_In_Stable_COPD_Patients">BODE Index Vs FEV1 In Predicting Outcome And Number Of Exacerbations In Stable COPD Patients</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="65581038" href="https://independent.academia.edu/IOSRJDMS">IOSR JDMS</a></div><p class="ds-related-work--abstract ds2-5-body-sm">The mechanisms underlying COPD exacerbations are poorly understood, and it is a high priority to identify factors that help in predicting their occurrence. Aim and Objectives: The present study was conducted to assess BODE index and GOLD severity staging (based on FEV1) in stable COPD patients, and to assess the utility of BODE index and GOLD severity staging in predicting acute exacerbations and their outcomes in the following one year. It is a hospital based prospective observational study done from Results:100 stable COPD patients were enrolled and were followed up for a period of one year or until their death whichever was earlier. 6 patients were lost to follow-up. Out of 94 patients; 23.40% had a BODE index of 0-2, 28.72% had a BODE index of 3-4, 20.21% had a BODE index of 5-6 and 27.67% had a BODE index of 7-10. Out of the 94 patients, 12.76%, 20.21%, 37.23% and 29.80% were categorized into GOLD stage 1, 2, 3 and 4 respectively. 38.29% of patients experienced at least one exacerbation, out of which, 5.31% of were managed with OP-based treatment. The remaining 32.97% of patients were hospitalized, of which, 12.76% succumbed to death. BODE index seems to be a better predictor of exacerbations (AUC=0.951) than FEV1 (AUC=0.794), with higher specificity rate. BODE index predicts OP based management of exacerbations better than FEV1 (AUC-0.916 vs 0.771). BODE index was also found to be a better predictor of hospitalization rates when compared to FEV1 (AUC—0.916 vs 0.771). BODE index was found to be a significant predictor of mortality with a AUC of 0.884 (p<0.0001) when compared to FEV1 (p=0.1379). Conclusion: BODE index and FEV1 were predictors of number of exacerbations, OP-based management and hospitalizations, but BODE index was found to be a better predictor than FEV1. 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