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Corneal opacity - Wikipedia

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id="toc-Nebular_corneal_opacity" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Nebular_corneal_opacity"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Nebular corneal opacity</span> </div> </a> <ul id="toc-Nebular_corneal_opacity-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Macular_corneal_opacity" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Macular_corneal_opacity"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Macular corneal opacity</span> </div> </a> <ul id="toc-Macular_corneal_opacity-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Leucomatous_corneal_opacity_(leucoma_simplex)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Leucomatous_corneal_opacity_(leucoma_simplex)"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.3</span> <span>Leucomatous corneal opacity (leucoma simplex)</span> </div> </a> <ul id="toc-Leucomatous_corneal_opacity_(leucoma_simplex)-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Presentation" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Presentation"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Presentation</span> </div> </a> <button aria-controls="toc-Presentation-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Presentation subsection</span> </button> <ul id="toc-Presentation-sublist" class="vector-toc-list"> <li id="toc-Complications" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Complications"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Complications</span> </div> </a> <ul id="toc-Complications-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Secondary_changes_in_corneal_opacity" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Secondary_changes_in_corneal_opacity"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Secondary changes in corneal opacity</span> </div> </a> <ul id="toc-Secondary_changes_in_corneal_opacity-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Causes" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Causes"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Causes</span> </div> </a> <ul id="toc-Causes-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Genetics" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Genetics"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Genetics</span> </div> 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class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Optical_iridectomy"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Optical iridectomy</span> </div> </a> <ul id="toc-Optical_iridectomy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Phototherapeutic_keratectomy_(PTK)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Phototherapeutic_keratectomy_(PTK)"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.3</span> <span>Phototherapeutic keratectomy (PTK)</span> </div> </a> <ul id="toc-Phototherapeutic_keratectomy_(PTK)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Tattooing_of_scar" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Tattooing_of_scar"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.4</span> <span>Tattooing of scar</span> </div> </a> <ul id="toc-Tattooing_of_scar-sublist" class="vector-toc-list"> 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<span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label 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searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Corneal opacity</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">Corneal scarring</td></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Corneal_opacity_right_eye_2.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/Corneal_opacity_right_eye_2.jpg/220px-Corneal_opacity_right_eye_2.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/Corneal_opacity_right_eye_2.jpg/330px-Corneal_opacity_right_eye_2.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/Corneal_opacity_right_eye_2.jpg/440px-Corneal_opacity_right_eye_2.jpg 2x" data-file-width="2318" data-file-height="1739" /></a></span></td></tr><tr><td colspan="2" class="infobox-full-data">Complete corneal opacity in right eye with normal left eye</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Ophthalmology" title="Ophthalmology">Ophthalmology</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Signs_and_symptoms" title="Signs and symptoms">Symptoms</a></th><td class="infobox-data">Loss of vision</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Complication_(medicine)" title="Complication (medicine)">Complications</a></th><td class="infobox-data">Blindness</td></tr><tr><th scope="row" class="infobox-label">Usual onset</th><td class="infobox-data">Congenital or acquired</td></tr><tr><th scope="row" class="infobox-label">Treatment</th><td class="infobox-data"><a href="/wiki/Corneal_transplantation" title="Corneal transplantation">Corneal transplantation</a></td></tr><tr><th scope="row" class="infobox-label">Frequency</th><td class="infobox-data">4th main cause of blindness globally (5.1%).<sup id="cite_ref-WHO-PED_1-0" class="reference"><a href="#cite_note-WHO-PED-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup></td></tr></tbody></table> <p><b>Corneal opacification</b> is a term used when the human <a href="/wiki/Cornea" title="Cornea">cornea</a> loses its transparency. The term <b>corneal opacity</b> is used particularly for the loss of transparency of cornea due to <a href="/wiki/Scarring" class="mw-redirect" title="Scarring">scarring</a>. Transparency of the cornea is dependent on the uniform diameter and the regular spacing and arrangement of the collagen fibrils within the <a href="/wiki/Stroma_of_cornea" title="Stroma of cornea">stroma</a>. Alterations in the spacing of <a href="/wiki/Collagen_fibrils" class="mw-redirect" title="Collagen fibrils">collagen fibrils</a> in a variety of conditions including corneal edema, scars, and <a href="/wiki/Macular_corneal_dystrophy" title="Macular corneal dystrophy">macular corneal dystrophy</a> is clinically manifested as corneal opacity.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> The term <b>corneal blindness</b> is commonly used to describe <a href="/wiki/Blindness" class="mw-redirect" title="Blindness">blindness</a> due to corneal opacity. </p><p><a href="/wiki/Keratoplasty" class="mw-redirect" title="Keratoplasty">Keratoplasty</a> also known as corneal transplantation is the main treatment option for visual improvement in corneal opacity. Other treatments which may improve visual outcome includes optical <a href="/wiki/Iridectomy" title="Iridectomy">iridectomy</a>, phototherapeutic keratectomy and <a href="/wiki/Keratoprosthesis" title="Keratoprosthesis">keratoprosthesises</a>. <a href="/wiki/Corneal_tattooing" title="Corneal tattooing">Corneal tattooing</a> may be used for improving the cosmetic appearance of the opaque eye. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Types">Types</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=1" title="Edit section: Types"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Corneaneo.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/Corneaneo.jpg/220px-Corneaneo.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/Corneaneo.jpg/330px-Corneaneo.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/87/Corneaneo.jpg/440px-Corneaneo.jpg 2x" data-file-width="3264" data-file-height="2448" /></a><figcaption> Corneal opacity with <a href="/wiki/Corneal_neovascularization" title="Corneal neovascularization">neovascularization</a></figcaption></figure> <p>Depending on the density, corneal opacity is graded as nebular, macular and leucomatous. </p> <div class="mw-heading mw-heading3"><h3 id="Nebular_corneal_opacity">Nebular corneal opacity</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=2" title="Edit section: Nebular corneal opacity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nebular corneal opacity is a faint opacity which results due to superficial scars involving Bowman's layer and superficial stroma. A nebular corneal opacity allows the details of the iris to be seen through the opacity. A thin, diffuse nebula covering the pupillary area interferes more with vision than a strictly localized dense leucoma, so long as the latter does not block the whole pupillary area. This is because the leucoma stops all the light which falls upon it, whereas the nebula refracts it irregularly, allowing many of the rays to fall upon the retina where they blur the image formed by the regularly refracted rays.<sup id="cite_ref-Parson_3-0" class="reference"><a href="#cite_note-Parson-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Macular_corneal_opacity">Macular corneal opacity</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=3" title="Edit section: Macular corneal opacity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Macular corneal opacity is a semidense opacity produced when scarring involves about half the corneal stroma.<sup id="cite_ref-Khurana_4-0" class="reference"><a href="#cite_note-Khurana-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Leucomatous_corneal_opacity_(leucoma_simplex)"><span id="Leucomatous_corneal_opacity_.28leucoma_simplex.29"></span>Leucomatous corneal opacity (leucoma simplex)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=4" title="Edit section: Leucomatous corneal opacity (leucoma simplex)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Leucomatous corneal opacity is a dense white opacity which results due to scarring of more than half of the stroma.<sup id="cite_ref-Khurana_4-1" class="reference"><a href="#cite_note-Khurana-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> A number of different presentations of leucomatous corneal opacity exist: </p> <ul><li>Adherent leucoma: results when healing occurs after perforation of cornea with incarceration of iris. The iris is adherent to the back of a leucomatous cornea. One of the major complication of adherent leucoma is <a href="/wiki/Secondary_glaucoma" title="Secondary glaucoma">Secondary glaucoma</a><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup></li> <li>Corneoiridic scar: if iris tissue is incarcerated and incorporated within the scar tissue, as occurs in healing of a large sloughed corneal ulcer, it is called a corneoiridic scar.<sup id="cite_ref-Parson_3-1" class="reference"><a href="#cite_note-Parson-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup></li> <li>Corneal facet: corneal surface depressed at the site of healing (due to less fibrous tissue); such a scar is called facet.<sup id="cite_ref-Khurana_4-2" class="reference"><a href="#cite_note-Khurana-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></li> <li>Kerectasia: In this condition, corneal curvature is increased at the site of opacity (bulge due to weak scar).<sup id="cite_ref-Khurana_4-3" class="reference"><a href="#cite_note-Khurana-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Presentation">Presentation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=5" title="Edit section: Presentation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Signs and symptoms include the following: </p> <ul><li>Loss of vision or blindness (when dense opacity covers the <a href="/wiki/Pupil_(eye)" class="mw-redirect" title="Pupil (eye)">pupillary area</a>)<sup id="cite_ref-Khurana-CO_6-0" class="reference"><a href="#cite_note-Khurana-CO-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/Blurred_vision" title="Blurred vision">Blurred vision</a> (due to <a href="/wiki/Astigmatism" title="Astigmatism">astigmatic effect</a> and <a href="/wiki/Light_scattering" class="mw-redirect" title="Light scattering">light scattering</a>)<sup id="cite_ref-CRST_7-0" class="reference"><a href="#cite_note-CRST-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/Glare_(vision)" title="Glare (vision)">Glare</a><sup id="cite_ref-NCBI-CO_8-0" class="reference"><a href="#cite_note-NCBI-CO-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Complications">Complications</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=6" title="Edit section: Complications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Congenital corneal opacity that affecting vision will cause amblyopia. That type of amblyopia is known as form-deprivation amblyopia (or amblyopia ex anopsia).<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Secondary_changes_in_corneal_opacity">Secondary changes in corneal opacity</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=7" title="Edit section: Secondary changes in corneal opacity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Secondary changes may be seen in long-standing cases include: hyaline degeneration, calcareous degeneration, pigmentation and atheromatous ulceration.<sup id="cite_ref-Khurana_4-4" class="reference"><a href="#cite_note-Khurana-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Causes">Causes</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=8" title="Edit section: Causes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Postmortem_changes_of_the_eye.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d0/Postmortem_changes_of_the_eye.jpg/220px-Postmortem_changes_of_the_eye.jpg" decoding="async" width="220" height="118" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d0/Postmortem_changes_of_the_eye.jpg/330px-Postmortem_changes_of_the_eye.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d0/Postmortem_changes_of_the_eye.jpg/440px-Postmortem_changes_of_the_eye.jpg 2x" data-file-width="3011" data-file-height="1613" /></a><figcaption>Corneal opacity or "clouding" also gradually appears after death, and can be used to estimate the <a href="/wiki/Postmortem_interval" class="mw-redirect" title="Postmortem interval">postmortem interval</a> (PMI).</figcaption></figure> <ul><li>Congenital opacities may occur as developmental anomalies or following birth trauma. Causes of congenital corneal opacities include sclerocornea, trauma, ulcer, <a href="/wiki/Mucopolysaccharidosis" title="Mucopolysaccharidosis">mucopolysaccharidosis</a>, <a href="/wiki/Peters_anomaly" class="mw-redirect" title="Peters anomaly">Peter’s anomaly</a>, <a href="/wiki/Congenital_hereditary_endothelial_dystrophy" title="Congenital hereditary endothelial dystrophy">congenital hereditary endothelial dystrophy</a>.<sup id="cite_ref-Parson_3-2" class="reference"><a href="#cite_note-Parson-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup></li> <li>Ocular trauma <sup id="cite_ref-WHO-CB_10-0" class="reference"><a href="#cite_note-WHO-CB-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/Corneal_ulcer" title="Corneal ulcer">Corneal ulceration</a> <sup id="cite_ref-WHO-CB_10-1" class="reference"><a href="#cite_note-WHO-CB-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/Xerophthalmia" title="Xerophthalmia">Xerophthalmia</a>, caused by <a href="/wiki/Vitamin_A_deficiency" title="Vitamin A deficiency">Vitamin A deficiency</a><sup id="cite_ref-WHO-CB_10-2" class="reference"><a href="#cite_note-WHO-CB-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/Trachoma" title="Trachoma">Trachoma</a><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">&#91;</span>11<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/Onchocerciasis" title="Onchocerciasis">Onchocerciasis</a><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">&#91;</span>12<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/Mucous_membrane_pemphigoid" title="Mucous membrane pemphigoid">Mucous membrane pemphigoid</a>: Ocular form of mucous membrane pemphigoid may cause corneal opacity and loss of vision.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">&#91;</span>13<span class="cite-bracket">&#93;</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Genetics">Genetics</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=9" title="Edit section: Genetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Pediatric corneal opacities may be congenital or acquired. </p> <div class="mw-heading mw-heading3"><h3 id="Congenital_corneal_opacities">Congenital corneal opacities</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=10" title="Edit section: Congenital corneal opacities"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Congenital reasons for this condition include: </p> <ul><li><b>Congenital hereditary endothelial dystrophy (CHED):</b> There are 2 forms of congenital hereditary endothelial dystrophy (CHED). Commonest is an autosomal recessive form, which is present at birth, but nonprogressive. Nystagmus is seen in association with this form. Another is an autosomal dominant form that occurs within the first few years of life. This form is progressive, but nystagmus is not seen. Deafness and CHED are seen in <a href="/wiki/Corneal_dystrophy-perceptive_deafness_syndrome" title="Corneal dystrophy-perceptive deafness syndrome">Harboyan syndrome</a>. The histologic findings are very similar to those seen in pseudophakic/ aphakic bullous keratopathy. The appearance of the cornea is similar to that in congenital glaucoma but without increased corneal diameter and elevated intraocular pressure.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">&#91;</span>14<span class="cite-bracket">&#93;</span></a></sup></li> <li><b>Posterior polymorphous corneal dystrophy (PPMD, PPCD)<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">&#91;</span>15<span class="cite-bracket">&#93;</span></a></sup></b>: PPCD, also known as Schlichting dystrophy, is an autosomal dominant disorder of the corneal endothelium and Descemet’s membrane. It is usually present in the second or third decade of life. It has the same entity as the first form of CHED. Most cases of PPMD are asymptomatic, and these cases generally do not require treatment. PPMD patients with bilateral, corneal opacities that can affect vision, descemet’s membrane endothelial keratoplasty or penetrating keratoplasty are the treatments of choice to improve vision and to avoid amblyopia.</li> <li><b>Congenital hereditary stromal dystrophy (CHSD)</b>: CHSD is also known as Congenital stromal corneal dystrophy or Congenital stromal dystrophy of the cornea. It is a rare autosomal dominant disease caused by mutations in the DCN gene.<sup id="cite_ref-GHR_16-0" class="reference"><a href="#cite_note-GHR-16"><span class="cite-bracket">&#91;</span>16<span class="cite-bracket">&#93;</span></a></sup> In this bilateral Snowflake, whitish opacities appear throughout the cornea.<sup id="cite_ref-Oxford_17-0" class="reference"><a href="#cite_note-Oxford-17"><span class="cite-bracket">&#91;</span>17<span class="cite-bracket">&#93;</span></a></sup> The stromal lamellae are abnormal and may be separated by amorphous deposits. Moderate to severe vision loss may occur due to corneal opacity. In case of severe vision loss, treatment of choice is penetrating keratoplasty.<sup id="cite_ref-Oxford_17-1" class="reference"><a href="#cite_note-Oxford-17"><span class="cite-bracket">&#91;</span>17<span class="cite-bracket">&#93;</span></a></sup></li> <li><b>Peters anomaly</b>:<sup id="cite_ref-Medscape_18-0" class="reference"><a href="#cite_note-Medscape-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> Peters anomaly, also known as iridocorneal adhesions or keratolenticular adhesions, is a posterior corneal defect with an overlying stromal opacity, often accompanied by adherent iris strands (Peters anomaly type 1). The size and density of the opacity can range from a mild to dense central leukoma.</li> <li><b>Congenital anterior staphyloma</b>:<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">&#91;</span>19<span class="cite-bracket">&#93;</span></a></sup> Congenital anterior staphyloma is a rare form of anterior segment dysgenesis that shares similarities with Peters anomaly. It is characterized by an ectatic protrusion of a central opacified cornea lined by uveal tissue. The protrusion extends beyond the plane of the eyelid margins and it can be unilateral or bilateral.</li> <li><b>Lattice corneal dystrophy</b>: Lattice corneal dystrophy is an autosomal-dominant characterized by amyloid deposition in the corneal stroma. Due to deposits, lattice-like corneal opacities may occur in stroma. Three types of dystrophies are there, type 1, type 2 and type 3.<sup id="cite_ref-Oxford_17-2" class="reference"><a href="#cite_note-Oxford-17"><span class="cite-bracket">&#91;</span>17<span class="cite-bracket">&#93;</span></a></sup> Type 1 is also known as Biber-Haab-Dimmer corneal dystrophy, TGFBI type Lattice Dystrophy, or Classic Lattice Dystrophy.<sup id="cite_ref-NCBI-LCD_20-0" class="reference"><a href="#cite_note-NCBI-LCD-20"><span class="cite-bracket">&#91;</span>20<span class="cite-bracket">&#93;</span></a></sup> LCD type II is not included in corneal dystrophies.<sup id="cite_ref-NCBI-LCD_20-1" class="reference"><a href="#cite_note-NCBI-LCD-20"><span class="cite-bracket">&#91;</span>20<span class="cite-bracket">&#93;</span></a></sup></li> <li><b>Granular corneal dystrophy</b>:<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">&#91;</span>21<span class="cite-bracket">&#93;</span></a></sup> Two types, Type 1 and Type 2 are there. Both have autosomal dominant inheritance. In Type 1, Discrete crumb-like opacities are seen in the central anterior stroma. Visual symptoms such as glare and photophobia may occur early in life. In Type 2, deposits begin to appear in early childhood or adolescence as tiny whitish dots in the anterior stroma. Larger stellate, ring, or snowflake opacities may occur in later stages. Decrease in vision starts earlier in type2 than type1.</li> <li><b>Sclerocornea</b>:<sup id="cite_ref-entokey-cco_22-0" class="reference"><a href="#cite_note-entokey-cco-22"><span class="cite-bracket">&#91;</span>22<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Sclerocornea" title="Sclerocornea">Sclerocornea</a> is a congenital disorder in which the cornea is opaque and resembles the sclera, making the limbus indistinct. The central cornea is clearer than the periphery.</li> <li><b>Cystinosis</b>: <a href="/wiki/Cystinosis" title="Cystinosis">Cystinosis</a> is a rare autosomal recessive metabolic disease characterized by elevated levels of cystine within the cell.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">&#91;</span>23<span class="cite-bracket">&#93;</span></a></sup> Early deposition of cystine crystals in the cornea cause tinsel-like corneal opacities.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">&#91;</span>24<span class="cite-bracket">&#93;</span></a></sup></li> <li><b>Ichthyosis</b>: <a href="/wiki/X-linked_ichthyosis" title="X-linked ichthyosis">X-linked ichthyosis</a> is a genetic skin disorder caused by the hereditary deficiency of the <a href="/wiki/Steroid_sulfatase" title="Steroid sulfatase">steroid sulfatase</a> enzyme. Ocular manifestations of XLI include superficial or deep corneal opacities.<sup id="cite_ref-POS_25-0" class="reference"><a href="#cite_note-POS-25"><span class="cite-bracket">&#91;</span>25<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">&#91;</span>26<span class="cite-bracket">&#93;</span></a></sup></li> <li><b><a href="/wiki/Trisomy_8" title="Trisomy 8">Trisomy 8 mosaicism</a> (T8M)</b>: It is a rare chromosome disorder caused by the presence of an extra chromosome 8 in some cells of the body. Dense corneal opacities may occur in trisomy 8 mosaicism.<sup id="cite_ref-POS_25-1" class="reference"><a href="#cite_note-POS-25"><span class="cite-bracket">&#91;</span>25<span class="cite-bracket">&#93;</span></a></sup></li> <li><b><a href="/wiki/Farber%27s_disease" class="mw-redirect" title="Farber&#39;s disease">Farber's disease</a></b>: Nodular corneal opacity may be seen in association with this rare autosomal recessive disease.<sup id="cite_ref-POS_25-2" class="reference"><a href="#cite_note-POS-25"><span class="cite-bracket">&#91;</span>25<span class="cite-bracket">&#93;</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Acquired_pediatric_corneal_opacities">Acquired pediatric corneal opacities</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=11" title="Edit section: Acquired pediatric corneal opacities"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Acquired reasons for this condition include: </p> <ul><li><b>Traumatic</b>: Traumatic breaks in Descemet membrane may cause corneal opacity. Injuries to Descemet membrane occur during delivery.<sup id="cite_ref-entokey-cco_22-1" class="reference"><a href="#cite_note-entokey-cco-22"><span class="cite-bracket">&#91;</span>22<span class="cite-bracket">&#93;</span></a></sup> Opacity is commonly unilateral.<sup id="cite_ref-Medscape_18-1" class="reference"><a href="#cite_note-Medscape-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup></li> <li><b>Congenital or infantile glaucoma</b>:<sup id="cite_ref-Medscape_18-2" class="reference"><a href="#cite_note-Medscape-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> In <a href="/wiki/Congenital_glaucoma" class="mw-redirect" title="Congenital glaucoma">Congenital glaucoma</a>, the cornea becomes edematous, cloudy, and enlarged. Treatment should be done to reduce Intraocular pressure.</li> <li><b>Congenital corneal ulcers</b>: Unilateral corneal opacity may occur in association with conjunctival injection and other signs of inflammation.<sup id="cite_ref-entokey-cco_22-2" class="reference"><a href="#cite_note-entokey-cco-22"><span class="cite-bracket">&#91;</span>22<span class="cite-bracket">&#93;</span></a></sup></li> <li><b>Mucopolysaccharidoses</b>:<sup id="cite_ref-entokey-cco_22-3" class="reference"><a href="#cite_note-entokey-cco-22"><span class="cite-bracket">&#91;</span>22<span class="cite-bracket">&#93;</span></a></sup> The <a href="/wiki/Mucopolysaccharidoses" class="mw-redirect" title="Mucopolysaccharidoses">mucopolysaccharidoses</a> are a group of inherited metabolic diseases caused by the absence or malfunctioning of certain enzymes the body needs to break down molecules called glycosaminoglycans.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">&#91;</span>27<span class="cite-bracket">&#93;</span></a></sup> It is an autosomal recessive disorder. Sometimes, Corneal haze may be present in early life. Treatment options for significant opacities include penetrating keratoplasty and DALK.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=12" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Keratoplasty">Keratoplasty</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=13" title="Edit section: Keratoplasty"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Keratoplasty" class="mw-redirect" title="Keratoplasty">Keratoplasty</a></div> <p><a href="/wiki/Keratoplasty" class="mw-redirect" title="Keratoplasty">Keratoplasty</a> also known as corneal transplantation is the main treatment option for visual improvement in corneal opacity. In this, the opaque cornea is replaced with donor tissue. Depending on type and density of corneal opacity different types of keratoplasty may be used such as:<sup id="cite_ref-ijmr_28-0" class="reference"><a href="#cite_note-ijmr-28"><span class="cite-bracket">&#91;</span>28<span class="cite-bracket">&#93;</span></a></sup> </p> <ul><li>Penetrating keratoplasty: It is the traditional full thickness corneal transplant procedure, in which trephine (a circular cutting device) is used to cut opaque cornea, a similar-sized portion of the donor cornea is removed with a second trephine. The removed part of donor cornea is known as <a href="/wiki/Corneal_button" title="Corneal button">corneal button</a>. The donor tissue is then sutured to the patient eye. Dense corneal opacity which occupies all the corneal layers may be treated with penetrating keratoplasty.<sup id="cite_ref-:0_29-0" class="reference"><a href="#cite_note-:0-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup></li> <li>Superficial lamellar keratoplasty: Superficial lamellar keratoplasty is used to treat superficial corneal opacities, which occupies superficial one third part of stroma. In this technique, the opaque part of the cornea is removed and replaced with donor tissue, leaving healthy part of the cornea including deeper parts of stroma and endothelium.<sup id="cite_ref-:0_29-1" class="reference"><a href="#cite_note-:0-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup></li> <li>Deep anterior lamellar keratoplasty: DALK may be considered in deep opacities with normal endothelium and descemet's membrane. In this procedure, the anterior layers of cornea are removed and replaced with donor tissue, leaving the <a href="/wiki/Corneal_endothelium" title="Corneal endothelium">endothelial layer</a> and the <a href="/wiki/Descemet%27s_membrane" title="Descemet&#39;s membrane">descemet's membrane</a> in place.<sup id="cite_ref-:0_29-2" class="reference"><a href="#cite_note-:0-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Optical_iridectomy">Optical iridectomy</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=14" title="Edit section: Optical iridectomy"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Optical iridectomy creates a clear entrance pupil, improving vision in patients with segmental corneal opacities. An area of clear peripheral cornea can produce retinal images compatible with good visual acuity.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Phototherapeutic_keratectomy_(PTK)"><span id="Phototherapeutic_keratectomy_.28PTK.29"></span>Phototherapeutic keratectomy (PTK)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=15" title="Edit section: Phototherapeutic keratectomy (PTK)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Excimer laser phototherapeutic keratectomy (PTK) is useful in superficial (nebular) corneal opacities.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">&#91;</span>31<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Tattooing_of_scar">Tattooing of scar</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=16" title="Edit section: Tattooing of scar"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Keratopigmentation or <a href="/wiki/Corneal_tattooing" title="Corneal tattooing">corneal tattooing</a> is a procedure used for centuries to improve the cosmetic appearance of corneal scars. Tattooing will not improve vision. For tattooing procedure Indian black ink, gold or platinum may be used.<sup id="cite_ref-Khurana_4-5" class="reference"><a href="#cite_note-Khurana-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Techniques">Techniques</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=17" title="Edit section: Techniques"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Staining method: In this technique, tattoo ink is directly applied to anterior surface of cornea. Benefits of this procedure include fast procedure with uniform dye application. Risk of fading is a main drawback.<sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup></li> <li>Femtosecond laser-assisted corneal tattooing: <a href="/wiki/Femtosecond_laser" class="mw-redirect" title="Femtosecond laser">Femtosecond laser</a>-assisted corneal tattooing is a new corneal tattooing technique, with many benefits.<sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Keratoprosthesis">Keratoprosthesis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=18" title="Edit section: Keratoprosthesis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Keratoprosthesis" title="Keratoprosthesis">Keratoprosthesis</a></div> <p><a href="/wiki/Keratoprosthesis" title="Keratoprosthesis">Keratoprosthesis</a> is a surgical procedure where damaged or opaque cornea is replaced with an artificial cornea. Artificial corneas currently in commercial use include <a href="/wiki/Boston_keratoprosthesis" title="Boston keratoprosthesis">Boston keratoprosthesis</a>, <a href="/wiki/Osteo-Odonto-Keratoprosthesis" class="mw-redirect" title="Osteo-Odonto-Keratoprosthesis">Osteo-Odonto-Keratoprosthesis</a> (OOKP), AlphaCor, KeraKlear Artificial Cornea etc.<sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">&#91;</span>34<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-healio_35-0" class="reference"><a href="#cite_note-healio-35"><span class="cite-bracket">&#91;</span>35<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=19" title="Edit section: Epidemiology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Corneal opacity is the 4th main cause of <a href="/wiki/Blindness" class="mw-redirect" title="Blindness">blindness</a> globally (5.1%).<sup id="cite_ref-WHO-PED_1-1" class="reference"><a href="#cite_note-WHO-PED-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Using the World Health Organization's (WHO; Geneva, Switzerland) blindness definition,1 45 million people worldwide are bilaterally blind, of which 6 to 8 million are blind due to corneal disease. In some African areas, nearly 90% of the total blindness is due to corneal pathology.<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">&#91;</span>36<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Europe">Europe</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=20" title="Edit section: Europe"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The prevalence of congenital corneal opacities (CCO) is estimated to be 3 in 100,000 newborns. This number increases to 6 in 100,000 if congenital glaucoma patients are included. A study of live births in Spain reported that corneal opacities accounted for 3.11% of congenital eye malformations (Bermejo et al, 1998). About 4% of keratoplasties done in the pediatric population in Denmark are due to congenital anomalies (Hovlykke et al, 2014).<sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">&#91;</span>37<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="India">India</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=21" title="Edit section: India"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In NPCB survey (2001–2002) Corneal opacity was the 6th major cause of blindness in India, which accounts for 0.9% of total blind population. In the RAAB (Rapid Assessment of Avoidable Blindness) survey (2006–2007) Corneal opacity including Trachoma was mentioned as the second major cause of blindness, which accounts for 6.5% of total blindness.<sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">&#91;</span>38<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=22" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Corneal_transplantation" title="Corneal transplantation">Corneal transplantation</a></li> <li><a href="/wiki/Corneal_ulcer" title="Corneal ulcer">Corneal ulcer</a></li> <li><a href="/wiki/Corneal_button" title="Corneal button">Corneal button</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Corneal_opacity&amp;action=edit&amp;section=23" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-WHO-PED-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-WHO-PED_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-WHO-PED_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20060322164215/http://www.who.int/blindness/causes/priority/en/index8.html">"WHO -Priority eye diseases"</a>. <i>www.who.int</i>. Archived from <a rel="nofollow" class="external text" href="https://www.who.int/blindness/causes/priority/en/index8.html">the original</a> on March 22, 2006.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=www.who.int&amp;rft.atitle=WHO+-Priority+eye+diseases&amp;rft_id=https%3A%2F%2Fwww.who.int%2Fblindness%2Fcauses%2Fpriority%2Fen%2Findex8.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3ACorneal+opacity" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJ_Alroy_,_M_Haskins,_D_E_Birk2001" class="citation journal cs1">J Alroy , M Haskins, D E Birk (2001). 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.navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Eye_pathology" title="Template:Eye pathology"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Eye_pathology" title="Template talk:Eye pathology"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Eye_pathology" title="Special:EditPage/Template:Eye pathology"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Diseases_of_the_human_eye" style="font-size:114%;margin:0 4em"><div class="hlist"><ul><li><a href="/wiki/Eye_disease" title="Eye disease">Diseases of the human eye</a></li></ul></div></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Adnexa" style="font-size:114%;margin:0 4em"><a href="/wiki/Accessory_visual_structures" title="Accessory visual structures">Adnexa</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Eyelid" title="Eyelid">Eyelid</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Inflammation" scope="row" class="navbox-group" style="width:1%">Inflammation</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Stye" title="Stye">Stye</a></li> <li><a href="/wiki/Chalazion" title="Chalazion">Chalazion</a></li> <li><a href="/wiki/Blepharitis" title="Blepharitis">Blepharitis</a></li> <li><a href="/wiki/Meibomian_gland_dysfunction" title="Meibomian gland dysfunction">Meibomian gland dysfunction</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Entropion" title="Entropion">Entropion</a></li> <li><a href="/wiki/Ectropion" title="Ectropion">Ectropion</a></li> <li><a href="/wiki/Lagophthalmos" title="Lagophthalmos">Lagophthalmos</a></li> <li><a href="/wiki/Blepharochalasis" title="Blepharochalasis">Blepharochalasis</a></li> <li><a href="/wiki/Ptosis_(eyelid)" title="Ptosis (eyelid)">Ptosis</a></li> <li><a href="/wiki/Blepharophimosis" title="Blepharophimosis">Blepharophimosis</a></li> <li><a href="/wiki/Xanthelasma" title="Xanthelasma">Xanthelasma</a></li> <li><a href="/wiki/Ankyloblepharon" title="Ankyloblepharon">Ankyloblepharon</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Eyelash" title="Eyelash">Eyelash</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Trichiasis" title="Trichiasis">Trichiasis</a></li> <li><a href="/wiki/Madarosis" title="Madarosis">Madarosis</a></li> <li><a href="/wiki/Distichiasis" class="mw-redirect" title="Distichiasis">Distichiasis</a></li> <li><a href="/wiki/Trichomegaly" title="Trichomegaly">Trichomegaly</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lacrimal_apparatus" title="Lacrimal apparatus">Lacrimal apparatus</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dacryoadenitis" title="Dacryoadenitis">Dacryoadenitis</a></li> <li><a href="/wiki/Epiphora_(medicine)" title="Epiphora (medicine)">Epiphora</a></li> <li><a href="/wiki/Dacryocystitis" title="Dacryocystitis">Dacryocystitis</a></li> <li><a href="/wiki/Xerophthalmia" title="Xerophthalmia">Xerophthalmia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Orbit_(anatomy)" title="Orbit (anatomy)">Orbit</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Exophthalmos" title="Exophthalmos">Exophthalmos</a></li> <li><a href="/wiki/Enophthalmos" title="Enophthalmos">Enophthalmos</a></li> <li><a href="/wiki/Orbital_cellulitis" title="Orbital cellulitis">Orbital cellulitis</a></li> <li><a href="/wiki/Orbital_lymphoma" title="Orbital lymphoma">Orbital lymphoma</a></li> <li><a href="/wiki/Periorbital_cellulitis" title="Periorbital cellulitis">Periorbital cellulitis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Conjunctiva" title="Conjunctiva">Conjunctiva</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chemosis" title="Chemosis">Chemosis</a></li> <li><a href="/wiki/Conjunctivitis" title="Conjunctivitis">Conjunctivitis</a> <ul><li><a href="/wiki/Allergic_conjunctivitis" title="Allergic conjunctivitis">allergic</a></li></ul></li> <li><a href="/wiki/Pterygium_(conjunctiva)" class="mw-redirect" title="Pterygium (conjunctiva)">Pterygium</a></li> <li><a href="/wiki/Pseudopterygium" title="Pseudopterygium">Pseudopterygium</a></li> <li><a href="/wiki/Pinguecula" title="Pinguecula">Pinguecula</a></li> <li><a href="/wiki/Subconjunctival_bleeding" title="Subconjunctival bleeding">Subconjunctival hemorrhage</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Globe" style="font-size:114%;margin:0 4em"><a href="/wiki/Globe_(human_eye)" title="Globe (human eye)">Globe</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibrous_tunic_of_eyeball" title="Fibrous tunic of eyeball">Fibrous tunic</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Sclera" title="Sclera">Sclera</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Scleritis" title="Scleritis">Scleritis</a></li> <li><a href="/wiki/Episcleritis" title="Episcleritis">Episcleritis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cornea" title="Cornea">Cornea</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Keratitis" title="Keratitis">Keratitis</a> <ul><li><a href="/wiki/Herpetic_keratitis" class="mw-redirect" title="Herpetic keratitis">herpetic</a></li> <li><a href="/wiki/Acanthamoeba_keratitis" title="Acanthamoeba keratitis">acanthamoebic</a></li> <li><a href="/wiki/Fungal_keratitis" title="Fungal keratitis">fungal</a></li> <li><a href="/wiki/Exposure_keratitis" class="mw-redirect" title="Exposure keratitis">Exposure</a></li> <li><a href="/wiki/Photokeratitis" title="Photokeratitis">Photokeratitis</a></li></ul></li> <li><a href="/wiki/Corneal_ulcer" title="Corneal ulcer">Corneal ulcer</a></li> <li><a href="/wiki/Thygeson%27s_superficial_punctate_keratopathy" title="Thygeson&#39;s superficial punctate keratopathy">Thygeson's superficial punctate keratopathy</a></li> <li><a href="/wiki/Corneal_dystrophy" title="Corneal dystrophy">Corneal dystrophy</a> <ul><li><a href="/wiki/Fuchs%27_dystrophy" title="Fuchs&#39; dystrophy">Fuchs'</a></li> <li><a href="/wiki/Meesmann_corneal_dystrophy" title="Meesmann corneal dystrophy">Meesmann</a></li></ul></li> <li><a href="/wiki/Corneal_ectatic_disorders" title="Corneal ectatic disorders">Corneal ectasia</a> <ul><li><a href="/wiki/Keratoconus" title="Keratoconus">Keratoconus</a></li> <li><a href="/wiki/Pellucid_marginal_degeneration" title="Pellucid marginal degeneration">Pellucid marginal degeneration</a></li> <li><a href="/wiki/Keratoglobus" title="Keratoglobus">Keratoglobus</a></li> <li><a href="/wiki/Terrien%27s_marginal_degeneration" title="Terrien&#39;s marginal degeneration">Terrien's marginal degeneration</a></li> <li><a href="/wiki/Post-LASIK_ectasia" title="Post-LASIK ectasia">Post-LASIK ectasia</a></li></ul></li> <li><a href="/wiki/Keratoconjunctivitis" title="Keratoconjunctivitis">Keratoconjunctivitis</a> <ul><li><a href="/wiki/Keratoconjunctivitis_sicca" class="mw-redirect" title="Keratoconjunctivitis sicca">sicca</a></li></ul></li> <li><a class="mw-selflink selflink">Corneal opacity</a></li> <li><a href="/wiki/Corneal_neovascularization" title="Corneal neovascularization">Corneal neovascularization</a></li> <li><a href="/wiki/Kayser%E2%80%93Fleischer_ring" title="Kayser–Fleischer ring">Kayser–Fleischer ring</a></li> <li><a href="/wiki/Haab%27s_striae" title="Haab&#39;s striae">Haab's striae</a></li> <li><a href="/wiki/Arcus_senilis" title="Arcus senilis">Arcus senilis</a></li> <li><a href="/wiki/Band_keratopathy" title="Band keratopathy">Band keratopathy</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Uvea" title="Uvea">Vascular tunic</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><div class="hlist"><ul><li><a href="/wiki/Iris_(anatomy)" title="Iris (anatomy)">Iris</a></li><li><a href="/wiki/Ciliary_body" title="Ciliary body">Ciliary body</a></li></ul></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Uveitis" title="Uveitis">Uveitis</a></li> <li><a href="/wiki/Intermediate_uveitis" title="Intermediate uveitis">Intermediate uveitis</a></li> <li><a href="/wiki/Hyphema" title="Hyphema">Hyphema</a></li> <li><a href="/wiki/Rubeosis_iridis" title="Rubeosis iridis">Rubeosis iridis</a></li> <li><a href="/wiki/Persistent_pupillary_membrane" title="Persistent pupillary membrane">Persistent pupillary membrane</a></li> <li><a href="/wiki/Iridodialysis" title="Iridodialysis">Iridodialysis</a></li> <li><a href="/wiki/Synechia_(eye)" title="Synechia (eye)">Synechia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Choroid" title="Choroid">Choroid</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Choroideremia" title="Choroideremia">Choroideremia</a></li> <li><a href="/wiki/Choroiditis" class="mw-redirect" title="Choroiditis">Choroiditis</a> <ul><li><a href="/wiki/Chorioretinitis" title="Chorioretinitis">Chorioretinitis</a></li></ul></li> <li><a href="/wiki/Focal_choroidal_excavation" title="Focal choroidal excavation">Focal choroidal excavation</a></li> <li><a href="/wiki/Polypoidal_choroidal_vasculopathy" title="Polypoidal choroidal vasculopathy">Polypoidal choroidal vasculopathy</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lens_(anatomy)" class="mw-redirect" title="Lens (anatomy)">Lens</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cataract" title="Cataract">Cataract</a> <ul><li><a href="/wiki/Congenital_cataract" title="Congenital cataract">Congenital cataract</a></li> <li><a href="/wiki/Childhood_cataract" title="Childhood cataract">Childhood cataract</a></li></ul></li> <li><a href="/wiki/Aphakia" title="Aphakia">Aphakia</a></li> <li><a href="/wiki/Ectopia_lentis" title="Ectopia lentis">Ectopia lentis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Retinal_disease" class="mw-redirect" title="Retinal disease">Retina</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinitis" title="Retinitis">Retinitis</a> <ul><li><a href="/wiki/Chorioretinitis" title="Chorioretinitis">Chorioretinitis</a></li> <li><a href="/wiki/Cytomegalovirus_retinitis" title="Cytomegalovirus retinitis">Cytomegalovirus retinitis</a></li></ul></li> <li><a href="/wiki/Retinal_detachment" title="Retinal detachment">Retinal detachment</a> <ul><li><a href="/wiki/Posterior_vitreous_detachment" title="Posterior vitreous detachment">Posterior vitreous detachment</a></li></ul></li> <li><a href="/wiki/Retinoschisis" title="Retinoschisis">Retinoschisis</a></li> <li><a href="/wiki/Ocular_ischemic_syndrome" title="Ocular ischemic syndrome">Ocular ischemic syndrome</a>&#160;/&#32;<a href="/wiki/Central_retinal_vein_occlusion" title="Central retinal vein occlusion">Central retinal vein occlusion</a></li> <li><a href="/wiki/Central_retinal_artery_occlusion" title="Central retinal artery occlusion">Central retinal artery occlusion</a></li> <li><a href="/wiki/Branch_retinal_artery_occlusion" title="Branch retinal artery occlusion">Branch retinal artery occlusion</a></li> <li><a href="/wiki/Retinopathy" title="Retinopathy">Retinopathy</a> <ul><li><a href="/wiki/Diabetic_retinopathy" title="Diabetic retinopathy">diabetic</a></li> <li><a href="/wiki/Hypertensive_retinopathy" title="Hypertensive retinopathy">hypertensive</a></li> <li><a href="/wiki/Purtscher%27s_retinopathy" title="Purtscher&#39;s retinopathy">Purtscher's</a></li> <li><a href="/wiki/Retinopathy_of_prematurity" title="Retinopathy of prematurity">of prematurity</a></li> <li><a href="/wiki/Bietti%27s_crystalline_dystrophy" title="Bietti&#39;s crystalline dystrophy">Bietti's crystalline dystrophy</a></li> <li><a href="/wiki/Coats%27_disease" title="Coats&#39; disease">Coats' disease</a></li> <li><a href="/wiki/Sickle_cell_retinopathy" title="Sickle cell retinopathy">Sickle cell</a></li> <li><a href="/wiki/Photic_retinopathy" title="Photic retinopathy">photic</a></li></ul></li> <li><a href="/wiki/Macular_degeneration" title="Macular degeneration">Macular degeneration</a></li> <li><a href="/wiki/Retinitis_pigmentosa" title="Retinitis pigmentosa">Retinitis pigmentosa</a></li> <li><a href="/wiki/Retinal_haemorrhage" title="Retinal haemorrhage">Retinal haemorrhage</a></li> <li><a href="/wiki/Central_serous_retinopathy" class="mw-redirect" title="Central serous retinopathy">Central serous retinopathy</a></li> <li><a href="/wiki/Macular_edema" title="Macular edema">Macular edema</a></li> <li><a href="/wiki/Epiretinal_membrane" title="Epiretinal membrane">Epiretinal membrane</a> (Macular pucker)</li> <li><a href="/wiki/Vitelliform_macular_dystrophy" title="Vitelliform macular dystrophy">Vitelliform macular dystrophy</a></li> <li><a href="/wiki/Leber%27s_congenital_amaurosis" class="mw-redirect" title="Leber&#39;s congenital amaurosis">Leber's congenital amaurosis</a></li> <li><a href="/wiki/Birdshot_chorioretinopathy" title="Birdshot chorioretinopathy">Birdshot chorioretinopathy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glaucoma" title="Glaucoma">Glaucoma</a>&#160;/&#32;<a href="/wiki/Ocular_hypertension" title="Ocular hypertension">Ocular hypertension</a>&#160;/&#32;<a href="/wiki/Primary_juvenile_glaucoma" class="mw-redirect" title="Primary juvenile glaucoma">Primary juvenile glaucoma</a></li> <li><a href="/wiki/Floater" title="Floater">Floater</a></li> <li><a href="/wiki/Leber%27s_hereditary_optic_neuropathy" title="Leber&#39;s hereditary optic neuropathy">Leber's hereditary optic neuropathy</a></li> <li><a href="/wiki/Ocular_hypotony" title="Ocular hypotony">Ocular hypotony</a></li> <li><a href="/wiki/Red_eye_(medicine)" title="Red eye (medicine)">Red eye</a></li> <li><a href="/wiki/Globe_rupture" title="Globe rupture">Globe rupture</a></li> <li><a href="/wiki/Fungal_keratitis" title="Fungal keratitis">Keratomycosis</a></li> <li><a href="/wiki/Phthisis_bulbi" title="Phthisis bulbi">Phthisis bulbi</a></li> <li><a href="/wiki/Persistent_fetal_vasculature" title="Persistent fetal vasculature">Persistent fetal vasculature</a></li> <li><a href="/wiki/Persistent_tunica_vasculosa_lentis" title="Persistent tunica vasculosa lentis">Persistent tunica vasculosa lentis</a></li> <li><a href="/wiki/Familial_exudative_vitreoretinopathy" title="Familial exudative vitreoretinopathy">Familial exudative vitreoretinopathy</a></li> <li><a href="/wiki/Vogt-Koyanagi-Harada_disease" class="mw-redirect" title="Vogt-Koyanagi-Harada disease">Vogt-Koyanagi-Harada disease</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Pathways" style="font-size:114%;margin:0 4em"><a href="/wiki/Visual_system" title="Visual system">Pathways</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Optic_nerve" title="Optic nerve">Optic nerve</a><br /><a href="/wiki/Optic_disc" title="Optic disc">Optic disc</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Optic_neuritis" title="Optic neuritis">Optic neuritis</a> <ul><li><a href="/wiki/Optic_papillitis" title="Optic papillitis">optic papillitis</a></li></ul></li> <li><a href="/wiki/Papilledema" title="Papilledema">Papilledema</a> <ul><li><a href="/wiki/Foster_Kennedy_syndrome" title="Foster Kennedy syndrome">Foster Kennedy syndrome</a></li></ul></li> <li><a href="/wiki/Optic_atrophy" class="mw-redirect" title="Optic atrophy">Optic atrophy</a></li> <li><a href="/wiki/Optic_disc_drusen" title="Optic disc drusen">Optic disc drusen</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Optic_neuropathy" title="Optic neuropathy">Optic neuropathy</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ischemic_optic_neuropathy" title="Ischemic optic neuropathy">Ischemic</a> <ul><li><a href="/wiki/Anterior_ischemic_optic_neuropathy" title="Anterior ischemic optic neuropathy">anterior&#160;(AION)</a></li> <li><a href="/wiki/Posterior_ischemic_optic_neuropathy" title="Posterior ischemic optic neuropathy">posterior&#160;(PION)</a></li> <li><a href="/wiki/Arteritic_anterior_ischemic_optic_neuropathy" title="Arteritic anterior ischemic optic neuropathy">arteritic anterior&#160;(AAION or arteritic AION)</a></li> <li><a href="/wiki/Non-arteritic_anterior_ischemic_optic_neuropathy" title="Non-arteritic anterior ischemic optic neuropathy">non-arteritic anterior&#160;(NAION)</a></li></ul></li> <li><a href="/wiki/Kjer%27s_optic_neuropathy" title="Kjer&#39;s optic neuropathy">Kjer's</a></li> <li><a href="/wiki/Leber%27s_hereditary_optic_neuropathy" title="Leber&#39;s hereditary optic neuropathy">Leber's hereditary</a></li> <li><a href="/wiki/Toxic_and_nutritional_optic_neuropathy" title="Toxic and nutritional optic neuropathy">Toxic and nutritional</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Strabismus" title="Strabismus">Strabismus</a><br /><a href="/wiki/Extraocular_muscles" title="Extraocular muscles">Extraocular muscles</a><br /><a href="/wiki/Binocular_vision" title="Binocular vision">Binocular vision</a><br /><a href="/wiki/Accommodation_(eye)" class="mw-redirect" title="Accommodation (eye)">Accommodation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Paralytic_strabismus" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Strabismus#Paralytic_strabismus" title="Strabismus">Paralytic strabismus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ophthalmoparesis" title="Ophthalmoparesis">Ophthalmoparesis</a></li> <li><a href="/wiki/Chronic_progressive_external_ophthalmoplegia" title="Chronic progressive external ophthalmoplegia">Chronic progressive external ophthalmoplegia</a></li> <li><a href="/wiki/Kearns%E2%80%93Sayre_syndrome" title="Kearns–Sayre syndrome">Kearns–Sayre syndrome</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cranial_nerve_disease" title="Cranial nerve disease">palsies</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Oculomotor_nerve_palsy" title="Oculomotor nerve palsy">Oculomotor (III)</a></li> <li><a href="/wiki/Fourth_nerve_palsy" title="Fourth nerve palsy">Fourth-nerve (IV)</a></li> <li><a href="/wiki/Sixth_nerve_palsy" title="Sixth nerve palsy">Sixth-nerve (VI)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Strabismus#Other_strabismus" title="Strabismus">Other strabismus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Esotropia" title="Esotropia">Esotropia</a>&#160;/&#32;<a href="/wiki/Exotropia" title="Exotropia">Exotropia</a></li> <li><a href="/wiki/Hypertropia" title="Hypertropia">Hypertropia</a></li> <li><a href="/wiki/Heterophoria" title="Heterophoria">Heterophoria</a> <ul><li><a href="/wiki/Esophoria" title="Esophoria">Esophoria</a></li> <li><a href="/wiki/Exophoria" title="Exophoria">Exophoria</a></li></ul></li> <li><a href="/wiki/Cyclotropia" title="Cyclotropia">Cyclotropia</a></li> <li><a href="/wiki/Brown%27s_syndrome" title="Brown&#39;s syndrome">Brown's syndrome</a></li> <li><a href="/wiki/Duane_syndrome" title="Duane syndrome">Duane syndrome</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other binocular</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Conjugate_gaze_palsy" title="Conjugate gaze palsy">Conjugate gaze palsy</a></li> <li><a href="/wiki/Convergence_insufficiency" title="Convergence insufficiency">Convergence insufficiency</a></li> <li><a href="/wiki/Internuclear_ophthalmoplegia" title="Internuclear ophthalmoplegia">Internuclear ophthalmoplegia</a></li> <li><a href="/wiki/One_and_a_half_syndrome" title="One and a half syndrome">One and a half syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Refraction" title="Refraction">Refraction</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Refractive_error" title="Refractive error">Refractive error</a> <ul><li><a href="/wiki/Far-sightedness" class="mw-redirect" title="Far-sightedness">Hyperopia</a></li> <li><a href="/wiki/Near-sightedness" class="mw-redirect" title="Near-sightedness">Myopia</a></li></ul></li> <li><a href="/wiki/Astigmatism" title="Astigmatism">Astigmatism</a></li> <li><a href="/wiki/Anisometropia" title="Anisometropia">Anisometropia</a>&#160;/&#32;<a href="/wiki/Aniseikonia" title="Aniseikonia">Aniseikonia</a></li> <li><a href="/wiki/Presbyopia" title="Presbyopia">Presbyopia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vision_disorder" title="Vision disorder">Vision disorders</a><br /><a href="/wiki/Blindness" class="mw-redirect" title="Blindness">Blindness</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amblyopia" title="Amblyopia">Amblyopia</a></li> <li><a href="/wiki/Leber%27s_congenital_amaurosis" class="mw-redirect" title="Leber&#39;s congenital amaurosis">Leber's congenital amaurosis</a></li> <li><a href="/wiki/Diplopia" title="Diplopia">Diplopia</a></li> <li><a href="/wiki/Scotoma" title="Scotoma">Scotoma</a></li> <li><a href="/wiki/Color_blindness" title="Color blindness">Color blindness</a> <ul><li><a href="/wiki/Achromatopsia" title="Achromatopsia">Achromatopsia</a></li> <li><a href="/wiki/Dichromacy" title="Dichromacy">Dichromacy</a></li> <li><a href="/wiki/Monochromacy" title="Monochromacy">Monochromacy</a></li></ul></li> <li><a href="/wiki/Nyctalopia" title="Nyctalopia">Nyctalopia</a> <ul><li><a href="/wiki/Oguchi_disease" title="Oguchi disease">Oguchi disease</a></li></ul></li> <li><a href="/wiki/Blindness" class="mw-redirect" title="Blindness">Blindness</a>&#160;/&#32;<a href="/wiki/Vision_loss" class="mw-redirect" title="Vision loss">Vision loss</a>&#160;/&#32;<a href="/wiki/Visual_impairment" title="Visual impairment">Visual impairment</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Anopsia" title="Anopsia">Anopsia</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hemianopsia" title="Hemianopsia">Hemianopsia</a> <ul><li><a href="/wiki/Binasal_hemianopsia" title="Binasal hemianopsia">binasal</a></li> <li><a href="/wiki/Bitemporal_hemianopsia" title="Bitemporal hemianopsia">bitemporal</a></li> <li><a href="/wiki/Homonymous_hemianopsia" title="Homonymous hemianopsia">homonymous</a></li></ul></li> <li><a href="/wiki/Quadrantanopia" title="Quadrantanopia">Quadrantanopia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">subjective</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Asthenopia" class="mw-redirect" title="Asthenopia">Asthenopia</a></li> <li><a href="/wiki/Hemeralopia" title="Hemeralopia">Hemeralopia</a></li> <li><a href="/wiki/Photophobia" title="Photophobia">Photophobia</a></li> <li><a href="/wiki/Scintillating_scotoma" title="Scintillating scotoma">Scintillating scotoma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pupil" title="Pupil">Pupil</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anisocoria" title="Anisocoria">Anisocoria</a></li> <li><a href="/wiki/Argyll_Robertson_pupil" title="Argyll Robertson pupil">Argyll Robertson pupil</a></li> <li><a href="/wiki/Marcus_Gunn_pupil" class="mw-redirect" title="Marcus Gunn pupil">Marcus Gunn pupil</a></li> <li><a href="/wiki/Adie_syndrome" title="Adie syndrome">Adie syndrome</a></li> <li><a href="/wiki/Miosis" title="Miosis">Miosis</a></li> <li><a href="/wiki/Mydriasis" title="Mydriasis">Mydriasis</a></li> <li><a href="/wiki/Cycloplegia" title="Cycloplegia">Cycloplegia</a></li> <li><a href="/wiki/Parinaud%27s_syndrome" title="Parinaud&#39;s syndrome">Parinaud's syndrome</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nystagmus" title="Nystagmus">Nystagmus</a></li> <li><a href="/wiki/Childhood_blindness" title="Childhood blindness">Childhood blindness</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Infections" style="font-size:114%;margin:0 4em"><a href="/wiki/Eye_disease" title="Eye disease">Infections</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Trachoma" title="Trachoma">Trachoma</a></li> <li><a href="/wiki/Onchocerciasis" title="Onchocerciasis">Onchocerciasis</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐web.codfw.main‐5857dfdcd6‐26bm6 Cached time: 20241203082232 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.638 seconds Real time usage: 0.742 seconds Preprocessor visited node count: 2804/1000000 Post‐expand include size: 162294/2097152 bytes Template argument size: 825/2097152 bytes Highest expansion depth: 10/100 Expensive parser function count: 3/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 149511/5000000 bytes Lua time usage: 0.377/10.000 seconds Lua memory usage: 6381342/52428800 bytes Number of Wikibase entities loaded: 0/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 590.906 1 -total 43.51% 257.084 1 Template:Reflist 26.04% 153.891 1 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