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</li> <li id="toc-Pathogenesis" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Pathogenesis"> <div class="vector-toc-text"> 2.2.3 Pathogenesis </div> </a> <ul id="toc-Pathogenesis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Serotypes_and_genotypes" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Serotypes_and_genotypes"> <div class="vector-toc-text"> 2.2.4 Serotypes and genotypes </div> </a> <ul id="toc-Serotypes_and_genotypes-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Mechanisms" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Mechanisms"> <div class="vector-toc-text"> 3 Mechanisms </div> </a> <ul id="toc-Mechanisms-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Diagnosis" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Diagnosis"> <div class="vector-toc-text"> 4 Diagnosis </div> </a> <ul id="toc-Diagnosis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Prevention" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Prevention"> <div class="vector-toc-text"> 5 Prevention </div> </a> <button aria-controls="toc-Prevention-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Prevention subsection </button> <ul id="toc-Prevention-sublist" class="vector-toc-list"> <li id="toc-Vaccine" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Vaccine"> <div class="vector-toc-text"> 5.1 Vaccine </div> </a> <ul id="toc-Vaccine-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Other" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Other"> <div class="vector-toc-text"> 5.2 Other </div> </a> <ul id="toc-Other-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Treatment" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Treatment"> <div class="vector-toc-text"> 6 Treatment </div> </a> <ul id="toc-Treatment-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Prognosis" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Prognosis"> <div class="vector-toc-text"> 7 Prognosis </div> </a> <button aria-controls="toc-Prognosis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Prognosis subsection </button> <ul id="toc-Prognosis-sublist" class="vector-toc-list"> <li id="toc-Cirrhosis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cirrhosis"> <div class="vector-toc-text"> 7.1 Cirrhosis </div> </a> <ul id="toc-Cirrhosis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reactivation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Reactivation"> <div class="vector-toc-text"> 7.2 Reactivation </div> </a> <ul id="toc-Reactivation-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Epidemiology" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Epidemiology"> <div class="vector-toc-text"> 8 Epidemiology </div> </a> <ul id="toc-Epidemiology-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> 9 History </div> </a> <ul id="toc-History-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> 10 Society and culture </div> </a> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> 11 See also </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> 12 References </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> 13 External links </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Toggle the table of contents </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading">Hepatitis B</h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 88 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-88" aria-hidden="true" > 88 languages </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Afrikaans" lang="af" hreflang="af" data-title="Hepatitis B" data-language-autonym="Afrikaans" data-language-local-name="Afrikaans" class="interlanguage-link-target">Afrikaans</a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A7%D9%84%D8%AA%D9%87%D8%A7%D8%A8_%D8%A7%D9%84%D9%83%D8%A8%D8%AF_%D8%A8" title="التهاب الكبد ب – Arabic" lang="ar" hreflang="ar" data-title="التهاب الكبد ب" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target">العربية</a></li><li class="interlanguage-link interwiki-as badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://as.wikipedia.org/wiki/%E0%A6%B9%E0%A7%87%E0%A6%AA%E0%A6%BE%E0%A6%9F%E0%A6%BE%E0%A6%87%E0%A6%9F%E0%A6%BF%E0%A6%9B_%E0%A6%AC%E0%A6%BF" title="হেপাটাইটিছ বি – Assamese" lang="as" hreflang="as" data-title="হেপাটাইটিছ বি" data-language-autonym="অসমীয়া" data-language-local-name="Assamese" class="interlanguage-link-target">অসমীয়া</a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Hepatit_B" title="Hepatit B – Azerbaijani" lang="az" hreflang="az" data-title="Hepatit B" data-language-autonym="Azərbaycanca" data-language-local-name="Azerbaijani" class="interlanguage-link-target">Azərbaycanca</a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%87%D9%BE%D8%A7%D8%AA%DB%8C%D8%AA_%D8%A8" title="هپاتیت ب – South Azerbaijani" lang="azb" hreflang="azb" data-title="هپاتیت ب" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target">تۆرکجه</a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%B9%E0%A7%87%E0%A6%AA%E0%A6%BE%E0%A6%9F%E0%A6%BE%E0%A6%87%E0%A6%9F%E0%A6%BF%E0%A6%B8_%E0%A6%AC%E0%A6%BF" title="হেপাটাইটিস বি – Bangla" lang="bn" hreflang="bn" data-title="হেপাটাইটিস বি" data-language-autonym="বাংলা" data-language-local-name="Bangla" class="interlanguage-link-target">বাংলা</a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D1%8B%D1%82_B" title="Гепатыт B – Belarusian" lang="be" hreflang="be" data-title="Гепатыт B" data-language-autonym="Беларуская" data-language-local-name="Belarusian" class="interlanguage-link-target">Беларуская</a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%A5%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82_B" title="Хепатит B – Bulgarian" lang="bg" hreflang="bg" data-title="Хепатит B" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target">Български</a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Catalan" lang="ca" hreflang="ca" data-title="Hepatitis B" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target">Català</a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Hepatitida_B" title="Hepatitida B – Czech" lang="cs" hreflang="cs" data-title="Hepatitida B" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target">Čeština</a></li><li class="interlanguage-link interwiki-ny mw-list-item"><a href="https://ny.wikipedia.org/wiki/Hepataitisi_B" title="Hepataitisi B – Nyanja" lang="ny" hreflang="ny" data-title="Hepataitisi B" data-language-autonym="Chi-Chewa" data-language-local-name="Nyanja" class="interlanguage-link-target">Chi-Chewa</a></li><li class="interlanguage-link interwiki-sn mw-list-item"><a href="https://sn.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Shona" lang="sn" hreflang="sn" data-title="Hepatitis B" data-language-autonym="ChiShona" data-language-local-name="Shona" class="interlanguage-link-target">ChiShona</a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Welsh" lang="cy" hreflang="cy" data-title="Hepatitis B" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target">Cymraeg</a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Danish" lang="da" hreflang="da" data-title="Hepatitis B" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target">Dansk</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – German" lang="de" hreflang="de" data-title="Hepatitis B" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-dv mw-list-item"><a href="https://dv.wikipedia.org/wiki/%DE%80%DE%AC%DE%95%DE%A6%DE%93%DE%A6%DE%87%DE%A8%DE%93%DE%A8%DE%90%DE%B0_%DE%84%DE%A9" title="ހެޕަޓައިޓިސް ބީ – Divehi" lang="dv" hreflang="dv" data-title="ހެޕަޓައިޓިސް ބީ" data-language-autonym="ދިވެހިބަސް" data-language-local-name="Divehi" class="interlanguage-link-target">ދިވެހިބަސް</a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/B-hepatiit" title="B-hepatiit – Estonian" lang="et" hreflang="et" data-title="B-hepatiit" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target">Eesti</a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%97%CF%80%CE%B1%CF%84%CE%AF%CF%84%CE%B9%CE%B4%CE%B1_%CE%92" title="Ηπατίτιδα Β – Greek" lang="el" hreflang="el" data-title="Ηπατίτιδα Β" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target">Ελληνικά</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Spanish" lang="es" hreflang="es" data-title="Hepatitis B" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/B_hepatitis" title="B hepatitis – Basque" lang="eu" hreflang="eu" data-title="B hepatitis" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target">Euskara</a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%87%D9%BE%D8%A7%D8%AA%DB%8C%D8%AA_%D8%A8" title="هپاتیت ب – Persian" lang="fa" hreflang="fa" data-title="هپاتیت ب" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target">فارسی</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/H%C3%A9patite_B" title="Hépatite B – French" lang="fr" hreflang="fr" data-title="Hépatite B" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Heipit%C3%ADteas_B" title="Heipitíteas B – Irish" lang="ga" hreflang="ga" data-title="Heipitíteas B" data-language-autonym="Gaeilge" data-language-local-name="Irish" class="interlanguage-link-target">Gaeilge</a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Hepatite_B" title="Hepatite B – Galician" lang="gl" hreflang="gl" data-title="Hepatite B" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target">Galego</a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/B%ED%98%95_%EA%B0%84%EC%97%BC" title="B형 간염 – Korean" lang="ko" hreflang="ko" data-title="B형 간염" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target">한국어</a></li><li class="interlanguage-link interwiki-ha mw-list-item"><a href="https://ha.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Hausa" lang="ha" hreflang="ha" data-title="Hepatitis B" data-language-autonym="Hausa" data-language-local-name="Hausa" class="interlanguage-link-target">Hausa</a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%80%D5%A5%D5%BA%D5%A1%D5%BF%D5%AB%D5%BF_B" title="Հեպատիտ B – Armenian" lang="hy" hreflang="hy" data-title="Հեպատիտ B" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target">Հայերեն</a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%B9%E0%A5%87%E0%A4%AA%E0%A5%87%E0%A4%9F%E0%A4%BE%E0%A4%87%E0%A4%9F%E0%A4%BF%E0%A4%B8_%E0%A4%AC%E0%A5%80" title="हेपेटाइटिस बी – Hindi" lang="hi" hreflang="hi" data-title="हेपेटाइटिस बी" data-language-autonym="हिन्दी" data-language-local-name="Hindi" class="interlanguage-link-target">हिन्दी</a></li><li class="interlanguage-link interwiki-ig mw-list-item"><a href="https://ig.wikipedia.org/wiki/Hepata%E1%BB%8Btis_B" title="Hepataịtis B – Igbo" lang="ig" hreflang="ig" data-title="Hepataịtis B" data-language-autonym="Igbo" data-language-local-name="Igbo" class="interlanguage-link-target">Igbo</a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Indonesian" lang="id" hreflang="id" data-title="Hepatitis B" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target">Bahasa Indonesia</a></li><li class="interlanguage-link interwiki-ia mw-list-item"><a href="https://ia.wikipedia.org/wiki/Hepatite_B" title="Hepatite B – Interlingua" lang="ia" hreflang="ia" data-title="Hepatite B" data-language-autonym="Interlingua" data-language-local-name="Interlingua" class="interlanguage-link-target">Interlingua</a></li><li class="interlanguage-link interwiki-it badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://it.wikipedia.org/wiki/Epatite_B" title="Epatite B – Italian" lang="it" hreflang="it" data-title="Epatite B" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target">Italiano</a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%94%D7%A4%D7%98%D7%99%D7%98%D7%99%D7%A1_B" title="הפטיטיס B – Hebrew" lang="he" hreflang="he" data-title="הפטיטיס B" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target">עברית</a></li><li class="interlanguage-link interwiki-ks mw-list-item"><a href="https://ks.wikipedia.org/wiki/%DB%81%DB%8C%D9%BE%D8%A7%D9%B9%D8%A7%D8%A6%D9%B9%D8%B3_B" title="ہیپاٹائٹس B – Kashmiri" lang="ks" hreflang="ks" data-title="ہیپاٹائٹس B" data-language-autonym="कॉशुर / کٲشُر" data-language-local-name="Kashmiri" class="interlanguage-link-target">कॉशुर / کٲشُر</a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%92%D0%B8%D1%80%D1%83%D1%81%D1%82%D1%8B_%D0%B3%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82_%D0%92" title="Вирусты гепатит В – Kazakh" lang="kk" hreflang="kk" data-title="Вирусты гепатит В" data-language-autonym="Қазақша" data-language-local-name="Kazakh" class="interlanguage-link-target">Қазақша</a></li><li class="interlanguage-link interwiki-rn mw-list-item"><a href="https://rn.wikipedia.org/wiki/Indwara_y%E2%80%99Igitigu" title="Indwara y’Igitigu – Rundi" lang="rn" hreflang="rn" data-title="Indwara y’Igitigu" data-language-autonym="Ikirundi" data-language-local-name="Rundi" class="interlanguage-link-target">Ikirundi</a></li><li class="interlanguage-link interwiki-sw mw-list-item"><a href="https://sw.wikipedia.org/wiki/Hepatitisi_B" title="Hepatitisi B – Swahili" lang="sw" hreflang="sw" data-title="Hepatitisi B" data-language-autonym="Kiswahili" data-language-local-name="Swahili" class="interlanguage-link-target">Kiswahili</a></li><li class="interlanguage-link interwiki-ku mw-list-item"><a href="https://ku.wikipedia.org/wiki/Zerika_re%C5%9F" title="Zerika reş – Kurdish" lang="ku" hreflang="ku" data-title="Zerika reş" data-language-autonym="Kurdî" data-language-local-name="Kurdish" class="interlanguage-link-target">Kurdî</a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Latin" lang="la" hreflang="la" data-title="Hepatitis B" data-language-autonym="Latina" data-language-local-name="Latin" class="interlanguage-link-target">Latina</a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/B_hepat%C4%ABts" title="B hepatīts – Latvian" lang="lv" hreflang="lv" data-title="B hepatīts" data-language-autonym="Latviešu" data-language-local-name="Latvian" class="interlanguage-link-target">Latviešu</a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Hepatitas_B" title="Hepatitas B – Lithuanian" lang="lt" hreflang="lt" data-title="Hepatitas B" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target">Lietuvių</a></li><li class="interlanguage-link interwiki-ln mw-list-item"><a href="https://ln.wikipedia.org/wiki/Epat%C3%ADte_B" title="Epatíte B – Lingala" lang="ln" hreflang="ln" data-title="Epatíte B" data-language-autonym="Lingála" data-language-local-name="Lingala" class="interlanguage-link-target">Lingála</a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Hepatitisz_B" title="Hepatitisz B – Hungarian" lang="hu" hreflang="hu" data-title="Hepatitisz B" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target">Magyar</a></li><li class="interlanguage-link interwiki-mad mw-list-item"><a href="https://mad.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Madurese" lang="mad" hreflang="mad" data-title="Hepatitis B" data-language-autonym="Madhurâ" data-language-local-name="Madurese" class="interlanguage-link-target">Madhurâ</a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%B9%E0%B5%86%E0%B4%AA%E0%B5%8D%E0%B4%AA%E0%B4%B1%E0%B5%8D%E0%B4%B1%E0%B5%88%E0%B4%B1%E0%B5%8D%E0%B4%B1%E0%B4%BF%E0%B4%B8%E0%B5%8D-%E0%B4%AC%E0%B4%BF" title="ഹെപ്പറ്റൈറ്റിസ്-ബി – Malayalam" lang="ml" hreflang="ml" data-title="ഹെപ്പറ്റൈറ്റിസ്-ബി" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target">മലയാളം</a></li><li class="interlanguage-link interwiki-mr mw-list-item"><a href="https://mr.wikipedia.org/wiki/%E0%A4%95%E0%A4%BE%E0%A4%B5%E0%A5%80%E0%A4%B3-%E0%A4%AC" title="कावीळ-ब – Marathi" lang="mr" hreflang="mr" data-title="कावीळ-ब" data-language-autonym="मराठी" data-language-local-name="Marathi" class="interlanguage-link-target">मराठी</a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/%D8%A7%D9%84%D8%AA%D9%87%D8%A7%D8%A8_%D8%A7%D9%84%D9%83%D8%A8%D8%AF_B" title="التهاب الكبد B – Egyptian Arabic" lang="arz" hreflang="arz" data-title="التهاب الكبد B" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target">مصرى</a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Malay" lang="ms" hreflang="ms" data-title="Hepatitis B" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target">Bahasa Melayu</a></li><li class="interlanguage-link interwiki-min mw-list-item"><a href="https://min.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Minangkabau" lang="min" hreflang="min" data-title="Hepatitis B" data-language-autonym="Minangkabau" data-language-local-name="Minangkabau" class="interlanguage-link-target">Minangkabau</a></li><li class="interlanguage-link interwiki-mn mw-list-item"><a href="https://mn.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82_B" title="Гепатит B – Mongolian" lang="mn" hreflang="mn" data-title="Гепатит B" data-language-autonym="Монгол" data-language-local-name="Mongolian" class="interlanguage-link-target">Монгол</a></li><li class="interlanguage-link interwiki-my mw-list-item"><a href="https://my.wikipedia.org/wiki/%E1%80%A1%E1%80%9E%E1%80%8A%E1%80%BA%E1%80%B8%E1%80%9B%E1%80%B1%E1%80%AC%E1%80%84%E1%80%BA_%E1%80%A1%E1%80%9E%E1%80%AC%E1%80%B8%E1%80%9D%E1%80%AB_%E1%80%9B%E1%80%B1%E1%80%AC%E1%80%82%E1%80%AB_%E1%80%98%E1%80%AE%E1%80%95%E1%80%AD%E1%80%AF%E1%80%B8" title="အသည်းရောင် အသားဝါ ရောဂါ ဘီပိုး – Burmese" lang="my" hreflang="my" data-title="အသည်းရောင် အသားဝါ ရောဂါ ဘီပိုး" data-language-autonym="မြန်မာဘာသာ" data-language-local-name="Burmese" class="interlanguage-link-target">မြန်မာဘာသာ</a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Dutch" lang="nl" hreflang="nl" data-title="Hepatitis B" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target">Nederlands</a></li><li class="interlanguage-link interwiki-ne mw-list-item"><a href="https://ne.wikipedia.org/wiki/%E0%A4%B9%E0%A5%87%E0%A4%AA%E0%A4%BE%E0%A4%9F%E0%A4%BE%E0%A4%87%E0%A4%9F%E0%A4%BF%E0%A4%B8_%E0%A4%AC%E0%A5%80" title="हेपाटाइटिस बी – Nepali" lang="ne" hreflang="ne" data-title="हेपाटाइटिस बी" data-language-autonym="नेपाली" data-language-local-name="Nepali" class="interlanguage-link-target">नेपाली</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/B%E5%9E%8B%E8%82%9D%E7%82%8E" title="B型肝炎 – Japanese" lang="ja" hreflang="ja" data-title="B型肝炎" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Hepatitt_B" title="Hepatitt B – Norwegian Nynorsk" lang="nn" hreflang="nn" data-title="Hepatitt B" data-language-autonym="Norsk nynorsk" data-language-local-name="Norwegian Nynorsk" class="interlanguage-link-target">Norsk nynorsk</a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Epatiti_B" title="Epatiti B – Occitan" lang="oc" hreflang="oc" data-title="Epatiti B" data-language-autonym="Occitan" data-language-local-name="Occitan" class="interlanguage-link-target">Occitan</a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B9%E0%AD%87%E0%AC%AA%E0%AC%BE%E0%AC%9F%E0%AC%BE%E0%AC%87%E0%AC%9F%E0%AC%BF%E0%AC%B8_%E0%AC%AC%E0%AC%BF" title="ହେପାଟାଇଟିସ ବି – Odia" lang="or" hreflang="or" data-title="ହେପାଟାଇଟିସ ବି" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target">ଓଡ଼ିଆ</a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Gepatit_B_viruslari" title="Gepatit B viruslari – Uzbek" lang="uz" hreflang="uz" data-title="Gepatit B viruslari" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target">Oʻzbekcha / ўзбекча</a></li><li class="interlanguage-link interwiki-pa mw-list-item"><a href="https://pa.wikipedia.org/wiki/%E0%A8%B9%E0%A9%88%E0%A8%AA%E0%A9%87%E0%A8%9F%E0%A8%BE%E0%A8%88%E0%A8%9F%E0%A8%BF%E0%A8%B8_%E0%A8%AC%E0%A9%80" title="ਹੈਪੇਟਾਈਟਿਸ ਬੀ – Punjabi" lang="pa" hreflang="pa" data-title="ਹੈਪੇਟਾਈਟਿਸ ਬੀ" data-language-autonym="ਪੰਜਾਬੀ" data-language-local-name="Punjabi" class="interlanguage-link-target">ਪੰਜਾਬੀ</a></li><li class="interlanguage-link interwiki-pnb mw-list-item"><a href="https://pnb.wikipedia.org/wiki/%DB%81%DB%8C%D9%BE%D8%A7%D9%B9%D8%A7%D8%A6%D9%B9%D8%B3_%D8%A8%DB%8C" title="ہیپاٹائٹس بی – Western Punjabi" lang="pnb" hreflang="pnb" data-title="ہیپاٹائٹس بی" data-language-autonym="پنجابی" data-language-local-name="Western Punjabi" class="interlanguage-link-target">پنجابی</a></li><li class="interlanguage-link interwiki-blk mw-list-item"><a href="https://blk.wikipedia.org/wiki/%E1%80%9A%E1%80%AC%E1%82%8F%E1%80%90%E1%80%9E%E1%80%AE%E1%80%B8%E1%80%9B%E1%80%B1%E1%80%AC%E1%82%8F%E1%80%82%E1%80%AB%E1%82%8F" title="ယာႏတသီးရောႏဂါႏ – Pa'O" lang="blk" hreflang="blk" data-title="ယာႏတသီးရောႏဂါႏ" data-language-autonym="ပအိုဝ်ႏဘာႏသာႏ" data-language-local-name="Pa'O" class="interlanguage-link-target">ပအိုဝ်ႏဘာႏသာႏ</a></li><li class="interlanguage-link interwiki-ps mw-list-item"><a href="https://ps.wikipedia.org/wiki/%D8%AA%D9%88%D8%B1_%D8%B2%DB%90%DA%93%DB%8C" title="تور زېړی – Pashto" lang="ps" hreflang="ps" data-title="تور زېړی" data-language-autonym="پښتو" data-language-local-name="Pashto" class="interlanguage-link-target">پښتو</a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Wirusowe_zapalenie_w%C4%85troby_typu_B" title="Wirusowe zapalenie wątroby typu B – Polish" lang="pl" hreflang="pl" data-title="Wirusowe zapalenie wątroby typu B" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target">Polski</a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Hepatite_B" title="Hepatite B – Portuguese" lang="pt" hreflang="pt" data-title="Hepatite B" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target">Português</a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Hepatit%C4%83_B" title="Hepatită B – Romanian" lang="ro" hreflang="ro" data-title="Hepatită B" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target">Română</a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82_B" title="Гепатит B – Russian" lang="ru" hreflang="ru" data-title="Гепатит B" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target">Русский</a></li><li class="interlanguage-link interwiki-sco mw-list-item"><a href="https://sco.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Scots" lang="sco" hreflang="sco" data-title="Hepatitis B" data-language-autonym="Scots" data-language-local-name="Scots" class="interlanguage-link-target">Scots</a></li><li class="interlanguage-link interwiki-st mw-list-item"><a href="https://st.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Southern Sotho" lang="st" hreflang="st" data-title="Hepatitis B" data-language-autonym="Sesotho" data-language-local-name="Southern Sotho" class="interlanguage-link-target">Sesotho</a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Simple English" lang="en-simple" hreflang="en-simple" data-title="Hepatitis B" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target">Simple English</a></li><li class="interlanguage-link interwiki-ss mw-list-item"><a href="https://ss.wikipedia.org/wiki/Ihepatitis_B" title="Ihepatitis B – Swati" lang="ss" hreflang="ss" data-title="Ihepatitis B" data-language-autonym="SiSwati" data-language-local-name="Swati" class="interlanguage-link-target">SiSwati</a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Hepatit%C3%ADda_typu_B" title="Hepatitída typu B – Slovak" lang="sk" hreflang="sk" data-title="Hepatitída typu B" data-language-autonym="Slovenčina" data-language-local-name="Slovak" class="interlanguage-link-target">Slovenčina</a></li><li class="interlanguage-link interwiki-sl badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://sl.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Slovenian" lang="sl" hreflang="sl" data-title="Hepatitis B" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target">Slovenščina</a></li><li class="interlanguage-link interwiki-so mw-list-item"><a href="https://so.wikipedia.org/wiki/Cagaarshow_B" title="Cagaarshow B – Somali" lang="so" hreflang="so" data-title="Cagaarshow B" data-language-autonym="Soomaaliga" data-language-local-name="Somali" class="interlanguage-link-target">Soomaaliga</a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%A5%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82%D0%B8%D1%81_%D0%91" title="Хепатитис Б – Serbian" lang="sr" hreflang="sr" data-title="Хепатитис Б" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target">Српски / srpski</a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Hepatitis_B" title="Hepatitis B – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Hepatitis B" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target">Srpskohrvatski / српскохрватски</a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Hepatit_B" title="Hepatit B – Swedish" lang="sv" hreflang="sv" data-title="Hepatit B" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target">Svenska</a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%88%E0%AE%B0%E0%AE%B2%E0%AF%8D_%E0%AE%85%E0%AE%B4%E0%AE%B1%E0%AF%8D%E0%AE%9A%E0%AE%BF_%E0%AE%AA%E0%AE%BF" title="ஈரல் அழற்சி பி – Tamil" lang="ta" hreflang="ta" data-title="ஈரல் அழற்சி பி" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target">தமிழ்</a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%B9%E0%B1%86%E0%B0%AA%E0%B0%9F%E0%B1%88%E0%B0%9F%E0%B0%BF%E0%B0%B8%E0%B1%8D%E2%80%8C-%E0%B0%AC%E0%B0%BF" title="హెపటైటిస్‌-బి – Telugu" lang="te" hreflang="te" data-title="హెపటైటిస్‌-బి" data-language-autonym="తెలుగు" data-language-local-name="Telugu" class="interlanguage-link-target">తెలుగు</a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%95%E0%B8%B1%E0%B8%9A%E0%B8%AD%E0%B8%B1%E0%B8%81%E0%B9%80%E0%B8%AA%E0%B8%9A_%E0%B8%9A%E0%B8%B5" title="ตับอักเสบ บี – Thai" lang="th" hreflang="th" data-title="ตับอักเสบ บี" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target">ไทย</a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Hepatit_B" title="Hepatit B – Turkish" lang="tr" hreflang="tr" data-title="Hepatit B" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target">Türkçe</a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%93%D0%B5%D0%BF%D0%B0%D1%82%D0%B8%D1%82_B" title="Гепатит B – Ukrainian" lang="uk" hreflang="uk" data-title="Гепатит B" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target">Українська</a></li><li class="interlanguage-link interwiki-ur mw-list-item"><a href="https://ur.wikipedia.org/wiki/%DB%81%DB%8C%D9%BE%D8%A7%D9%B9%D8%A7%D8%A6%D9%B9%D8%B3_%D8%A8%DB%8C" title="ہیپاٹائٹس بی – Urdu" lang="ur" hreflang="ur" data-title="ہیپاٹائٹس بی" data-language-autonym="اردو" data-language-local-name="Urdu" class="interlanguage-link-target">اردو</a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Vi%C3%AAm_gan_B" title="Viêm gan B – Vietnamese" lang="vi" hreflang="vi" data-title="Viêm gan B" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target">Tiếng Việt</a></li><li class="interlanguage-link interwiki-wo mw-list-item"><a href="https://wo.wikipedia.org/wiki/Hepatite_B" title="Hepatite B – Wolof" lang="wo" hreflang="wo" data-title="Hepatite B" data-language-autonym="Wolof" data-language-local-name="Wolof" class="interlanguage-link-target">Wolof</a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E4%B9%99%E5%9E%8B%E8%82%9D%E7%82%8E" title="乙型肝炎 – Wu" lang="wuu" hreflang="wuu" data-title="乙型肝炎" data-language-autonym="吴语" data-language-local-name="Wu" class="interlanguage-link-target">吴语</a></li><li class="interlanguage-link interwiki-yo mw-list-item"><a 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Click here for more information." src="//upload.wikimedia.org/wikipedia/en/thumb/9/94/Symbol_support_vote.svg/19px-Symbol_support_vote.svg.png" decoding="async" width="19" height="20" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/9/94/Symbol_support_vote.svg/29px-Symbol_support_vote.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/9/94/Symbol_support_vote.svg/39px-Symbol_support_vote.svg.png 2x" data-file-width="180" data-file-height="185" /></a></div></div> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Human viral infection</div> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Hepatitis B</th></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><a href="/wiki/File:Hepatitis-B_virions.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/12/Hepatitis-B_virions.jpg/220px-Hepatitis-B_virions.jpg" decoding="async" width="220" height="144" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/12/Hepatitis-B_virions.jpg/330px-Hepatitis-B_virions.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/12/Hepatitis-B_virions.jpg/440px-Hepatitis-B_virions.jpg 2x" data-file-width="700" data-file-height="458" /></a></td></tr><tr><td colspan="2" class="infobox-full-data"><a href="/wiki/Transmission_electron_microscopy" title="Transmission electron microscopy">Electron micrograph</a> of <a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">hepatitis B virus</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Infectious_disease_(medical_specialty)" class="mw-redirect" title="Infectious disease (medical specialty)">Infectious disease</a>, <a href="/wiki/Gastroenterology" title="Gastroenterology">gastroenterology</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Signs_and_symptoms" title="Signs and symptoms">Symptoms</a></th><td class="infobox-data">None, <a href="/wiki/Jaundice" title="Jaundice">yellowish skin</a>, <a href="/wiki/Fatigue_(medicine)" class="mw-redirect" title="Fatigue (medicine)">tiredness</a>, dark urine, <a href="/wiki/Abdominal_pain" title="Abdominal pain">abdominal pain</a><a href="#cite_note-WHO2022-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Complication_(medicine)" title="Complication (medicine)">Complications</a></th><td class="infobox-data"><a href="/wiki/Cirrhosis" title="Cirrhosis">Cirrhosis</a>, <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">liver cancer</a><a href="#cite_note-pmid17336170-2">[2]</a></td></tr><tr><th scope="row" class="infobox-label">Usual onset</th><td class="infobox-data">Symptoms may take up to 6 months to appear<a href="#cite_note-WHO2022-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label">Duration</th><td class="infobox-data">Short or long term<a href="#cite_note-GBD2015Pre-3">[3]</a></td></tr><tr><th scope="row" class="infobox-label">Causes</th><td class="infobox-data"><a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">Hepatitis B virus</a> spread by some <a href="/wiki/Body_fluids" class="mw-redirect" title="Body fluids">body fluids</a><a href="#cite_note-WHO2022-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Risk_factor" title="Risk factor">Risk factors</a></th><td class="infobox-data"><a href="/wiki/Intravenous_drug_use" class="mw-redirect" title="Intravenous drug use">Intravenous drug use</a>, <a href="/wiki/Sexual_intercourse" title="Sexual intercourse">sexual intercourse</a>, <a href="/wiki/Kidney_dialysis" title="Kidney dialysis">dialysis</a>, living with an infected person<a href="#cite_note-WHO2014-4">[4]</a><a href="#cite_note-CDC2014T-5">[5]</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_diagnosis" title="Medical diagnosis">Diagnostic method</a></th><td class="infobox-data">Blood tests<a href="#cite_note-WHO2022-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label">Prevention</th><td class="infobox-data"><a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">Hepatitis B vaccine</a><a href="#cite_note-WHO2022-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label">Treatment</th><td class="infobox-data"><a href="/wiki/Antiviral_medication" class="mw-redirect" title="Antiviral medication">Antiviral medication</a> (<a href="/wiki/Tenofovir" class="mw-redirect" title="Tenofovir">tenofovir</a>, <a href="/wiki/Interferon" title="Interferon">interferon</a>), <a href="/wiki/Liver_transplantation" title="Liver transplantation">liver transplantation</a><a href="#cite_note-WHO2014-4">[4]</a></td></tr><tr><th scope="row" class="infobox-label">Frequency</th><td class="infobox-data">296 million (2019)<a href="#cite_note-WHO2022-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label">Deaths</th><td class="infobox-data">820,000 resulting from hepatitis B (2019)<a href="#cite_note-WHO2022-1">[1]</a></td></tr></tbody></table> Hepatitis B is an <a href="/wiki/Infectious_disease" class="mw-redirect" title="Infectious disease">infectious disease</a> caused by the <a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">hepatitis B virus</a> (HBV) that affects the <a href="/wiki/Liver" title="Liver">liver</a>;<a href="#cite_note-WHO2022-1">[1]</a><a href="#cite_note-6">[6]</a> it is a type of <a href="/wiki/Viral_hepatitis" title="Viral hepatitis">viral hepatitis</a>.<a href="#cite_note-7">[7]</a> It can cause both acute and <a href="/wiki/Chronic_infection" class="mw-redirect" title="Chronic infection">chronic infection</a>.<a href="#cite_note-WHO2022-1">[1]</a> Many people have no symptoms during an initial infection. For others, symptoms may appear 30 to 180 days after becoming infected and can include a rapid onset of sickness with <a href="/wiki/Nausea" title="Nausea">nausea</a>, <a href="/wiki/Vomiting" title="Vomiting">vomiting</a>, <a href="/wiki/Jaundice" title="Jaundice">yellowish skin</a>, <a href="/wiki/Fatigue" title="Fatigue">fatigue</a>, yellow urine, and <a href="/wiki/Abdominal_pain" title="Abdominal pain">abdominal pain</a>.<a href="#cite_note-WHO2022-1">[1]</a> Symptoms during acute infection typically last for a few weeks, though some people may feel sick for up to six months.<a href="#cite_note-CDCFAQ2022-8">[8]</a> Deaths resulting from acute stage HBV infections are rare.<a href="#cite_note-9">[9]</a> An HBV infection lasting longer than six months is usually considered chronic.<a href="#cite_note-WHO2022-1">[1]</a> The likelihood of developing chronic hepatitis B is higher for those who are infected with HBV at a younger age. About 90% of those infected during or shortly after birth develop chronic hepatitis B,<a href="#cite_note-CDCFAQ2022-8">[8]</a> while less than 10% of those infected after the age of five develop chronic cases.<a href="#cite_note-CDC2014T-5">[5]</a> Most of those with chronic disease have no symptoms; however, <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a> and <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">liver cancer</a> eventually develop<a href="#cite_note-pmid17336170-2">[2]</a> in about 25% of those with chronic HBV.<a href="#cite_note-WHO2014-4">[4]</a> The virus is transmitted by exposure to infectious <a href="/wiki/Blood" title="Blood">blood</a> or <a href="/wiki/Body_fluids" class="mw-redirect" title="Body fluids">body fluids</a>.<a href="#cite_note-WHO2014-4">[4]</a> In areas where the disease is <a href="/wiki/Endemic" class="mw-redirect" title="Endemic">common</a>, <a href="/wiki/Perinatal_infection" class="mw-redirect" title="Perinatal infection">infection around the time of birth</a> or from contact with other people's blood during childhood are the most frequent methods by which hepatitis B is acquired.<a href="#cite_note-WHO2014-4">[4]</a> In areas where the disease is rare, <a href="/wiki/Intravenous_drug_use" class="mw-redirect" title="Intravenous drug use">intravenous drug use</a> and <a href="/wiki/Sexual_intercourse" title="Sexual intercourse">sexual intercourse</a> are the most frequent <a href="/wiki/Routes_of_infection" class="mw-redirect" title="Routes of infection">routes of infection</a>.<a href="#cite_note-WHO2014-4">[4]</a> Other risk factors include working in healthcare, <a href="/wiki/Blood_transfusions" class="mw-redirect" title="Blood transfusions">blood transfusions</a>, <a href="/wiki/Kidney_dialysis" title="Kidney dialysis">dialysis</a>, living with an infected person, travel in countries with high infection rates, and living in an institution.<a href="#cite_note-WHO2014-4">[4]</a><a href="#cite_note-CDC2014T-5">[5]</a> <a href="/wiki/Tattoo" title="Tattoo">Tattooing</a> and <a href="/wiki/Acupuncture" title="Acupuncture">acupuncture</a> led to a significant number of cases in the 1980s; however, this has become less common with improved sterilization.<a href="#cite_note-10">[10]</a> The hepatitis B viruses cannot be spread by holding hands, sharing eating utensils, kissing, hugging, coughing, sneezing, or breastfeeding.<a href="#cite_note-CDC2014T-5">[5]</a> The infection can be diagnosed 30 to 60 days after exposure.<a href="#cite_note-WHO2014-4">[4]</a> The diagnosis is usually confirmed by testing the blood for parts of the virus and for <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a> against the virus.<a href="#cite_note-WHO2014-4">[4]</a> It is one of five main <a href="/wiki/Hepatitis" title="Hepatitis">hepatitis</a> viruses: <a href="/wiki/Hepatitis_A" title="Hepatitis A">A</a>, B, <a href="/wiki/Hepatitis_C" title="Hepatitis C">C</a>, <a href="/wiki/Hepatitis_D" title="Hepatitis D">D</a>, and <a href="/wiki/Hepatitis_E" title="Hepatitis E">E</a>.<a href="#cite_note-WHO2017Report-11">[11]</a> During an initial infection, care is based on a person's symptoms.<a href="#cite_note-WHO2014-4">[4]</a> In those who develop chronic disease, <a href="/wiki/Antiviral_medication" class="mw-redirect" title="Antiviral medication">antiviral medication</a> such as <a href="/wiki/Tenofovir" class="mw-redirect" title="Tenofovir">tenofovir</a> or <a href="/wiki/Interferon" title="Interferon">interferon</a> may be useful; however, these drugs are expensive.<a href="#cite_note-WHO2014-4">[4]</a> <a href="/wiki/Liver_transplantation" title="Liver transplantation">Liver transplantation</a> is sometimes recommended for cases of cirrhosis or <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">hepatocellular carcinoma</a>.<a href="#cite_note-WHO2014-4">[4]</a> Hepatitis B infection has been preventable by <a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">vaccination</a> since 1982.<a href="#cite_note-WHO2014-4">[4]</a><a href="#cite_note-pmid17673066-12">[12]</a> As of 2022, the hepatitis B vaccine is between 98% and 100% effective in preventing infection.<a href="#cite_note-WHO2022-1">[1]</a> The vaccine is administered in several doses; after an initial dose, two or three more vaccine doses are required at a later time for full effect.<a href="#cite_note-WHO2022-1">[1]</a> The <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> (WHO) recommends infants receive the vaccine within 24 hours after birth when possible.<a href="#cite_note-WHO2022-1">[1]</a> National programs have made the hepatitis B vaccine available for infants in 190 countries as of the end of 2021.<a href="#cite_note-13">[13]</a><a href="#cite_note-Will2006-14">[14]</a> To further prevent infection, the WHO recommends testing all donated blood for hepatitis B before using it for transfusion. Using antiviral prophylaxis to prevent mother-to-child transmission is also recommended, as is following safe sex practices, including the use of <a href="/wiki/Condoms" class="mw-redirect" title="Condoms">condoms</a>.<a href="#cite_note-WHO2022-1">[1]</a> In 2016, the WHO set a goal of eliminating viral hepatitis as a threat to global <a href="/wiki/Public_health" title="Public health">public health</a> by 2030. Achieving this goal would require the development of therapeutic treatments to cure chronic hepatitis B, as well as preventing its transmission and using vaccines to prevent new infections.<a href="#cite_note-Block-15">[15]</a><a href="#cite_note-Cox-16">[16]</a><a href="#cite_note-WHO2016-17">[17]</a> An estimated 296 million people, or 3.8% of the global population, had chronic hepatitis B infections as of 2019. Another 1.5 million developed acute infections that year, and 820,000 deaths occurred as a result of HBV.<a href="#cite_note-WHO2022-1">[1]</a> Cirrhosis and liver cancer are responsible for most HBV-related deaths.<a href="#cite_note-Epidemiology2021-18">[18]</a> The disease is most prevalent in Africa (affecting 7.5% of the continent's population) and in the Western Pacific region (5.9%).<a href="#cite_note-WHOProgress2021-19">[19]</a> Infection rates are 1.5% in Europe and 0.5% in the Americas.<a href="#cite_note-WHOProgress2021-19">[19]</a> According to some estimates, about a third of the world's population has been infected with hepatitis B at one point in their lives.<a href="#cite_note-Epidemiology2021-18">[18]</a> Hepatitis B was originally known as "serum hepatitis".<a href="#cite_note-Barker1996-20">[20]</a> <style data-mw-deduplicate="TemplateStyles:r886046785">.mw-parser-output .toclimit-2 .toclevel-1 ul,.mw-parser-output .toclimit-3 .toclevel-2 ul,.mw-parser-output .toclimit-4 .toclevel-3 ul,.mw-parser-output .toclimit-5 .toclevel-4 ul,.mw-parser-output .toclimit-6 .toclevel-5 ul,.mw-parser-output .toclimit-7 .toclevel-6 ul{display:none}</style><div class="toclimit-3"><meta property="mw:PageProp/toc" /></div> <div class="mw-heading mw-heading2"><h2 id="Signs_and_symptoms">Signs and symptoms</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=1" title="Edit section: Signs and symptoms">edit</a>]</div> Acute infection with hepatitis B virus is associated with acute viral <a href="/wiki/Hepatitis" title="Hepatitis">hepatitis</a>, an illness that begins with general ill-health, loss of appetite, nausea, vomiting, body aches, mild fever, and dark urine, and then progresses to development of <a href="/wiki/Jaundice" title="Jaundice">jaundice</a>. The illness lasts for a few weeks and then gradually improves in most affected people. A few people may have a more severe form of liver disease known as <a href="/wiki/Fulminant_hepatic_failure" class="mw-redirect" title="Fulminant hepatic failure">fulminant hepatic failure</a> and may die as a result. The infection may be entirely asymptomatic and may go unrecognized.<a href="#cite_note-21">[21]</a> Chronic infection with hepatitis B virus may be asymptomatic or may be associated with chronic inflammation of the liver (chronic hepatitis), leading to <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a> over a period of several years. This type of infection dramatically increases the incidence of <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">hepatocellular carcinoma</a> (HCC; liver cancer). Across Europe, hepatitis B and C cause approximately 50% of hepatocellular carcinomas.<a href="#cite_note-pmid17570226-22">[22]</a><a href="#cite_note-pmid21992124-23">[23]</a> Chronic carriers are encouraged to avoid consuming <a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">alcohol</a> as it increases their risk for <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a> and liver cancer. Hepatitis B virus has been linked to the development of <a href="/wiki/Membranous_glomerulonephritis" title="Membranous glomerulonephritis">membranous glomerulonephritis</a> (MGN).<a href="#cite_note-24">[24]</a> Symptoms outside of the liver are present in 1–10% of HBV-infected people and include <a href="/wiki/Serum-sickness%E2%80%93like_syndrome" class="mw-redirect" title="Serum-sickness–like syndrome">serum-sickness–like syndrome</a>, <a href="/wiki/Acute_necrotizing_vasculitis" class="mw-redirect" title="Acute necrotizing vasculitis">acute necrotizing vasculitis</a> (<a href="/wiki/Polyarteritis_nodosa" title="Polyarteritis nodosa">polyarteritis nodosa</a>), membranous glomerulonephritis, and <a href="/wiki/Papular_acrodermatitis_of_childhood" class="mw-redirect" title="Papular acrodermatitis of childhood">papular acrodermatitis of childhood</a> (<a href="/wiki/Gianotti%E2%80%93Crosti_syndrome" title="Gianotti–Crosti syndrome">Gianotti–Crosti syndrome</a>).<a href="#cite_note-pmid6126007-25">[25]</a><a href="#cite_note-pmid11334492-26">[26]</a> The serum-sickness–like syndrome occurs in the setting of acute hepatitis B, often preceding the onset of jaundice.<a href="#cite_note-pmid4996611-27">[27]</a> The clinical features are fever, <a href="/wiki/Skin_rash" class="mw-redirect" title="Skin rash">skin rash</a>, and <a href="/wiki/Polyarteritis" class="mw-redirect" title="Polyarteritis">polyarteritis</a>. The symptoms often subside shortly after the onset of jaundice but can persist throughout the duration of acute hepatitis B.<a href="#cite_note-pmid19399811-28">[28]</a> About 30–50% of people with acute necrotizing vasculitis (polyarteritis nodosa) are HBV carriers.<a href="#cite_note-pmid4098431-29">[29]</a> HBV-associated <a href="/wiki/Nephropathy" class="mw-redirect" title="Nephropathy">nephropathy</a> has been described in adults but is more common in children.<a href="#cite_note-pmid2023605-30">[30]</a><a href="#cite_note-pmid82085-31">[31]</a> Membranous glomerulonephritis is the most common form.<a href="#cite_note-pmid19399811-28">[28]</a> Other immune-mediated <a href="/wiki/Hematological" class="mw-redirect" title="Hematological">hematological</a> disorders, such as essential mixed <a href="/wiki/Cryoglobulinemia" title="Cryoglobulinemia">cryoglobulinemia</a> and <a href="/wiki/Aplastic_anemia" title="Aplastic anemia">aplastic anemia</a> have been described as part of the extrahepatic manifestations of HBV infection, but their association is not as well-defined; therefore, they probably should not be considered etiologically linked to HBV.<a href="#cite_note-pmid19399811-28">[28]</a> <div class="mw-heading mw-heading2"><h2 id="Cause">Cause</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=2" title="Edit section: Cause">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Transmission">Transmission</h3>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=3" title="Edit section: Transmission">edit</a>]</div> Transmission of hepatitis B virus results from exposure to infectious blood or body fluids containing blood. HBV is 50 to 100 times more infectious than <a href="/wiki/HIV" title="HIV">human immunodeficiency virus (HIV)</a>.<a href="#cite_note-32">[32]</a> HBV can be transmitted through several routes of infection. In <a href="/wiki/Vertically_transmitted_infection" title="Vertically transmitted infection">vertical transmission</a>, HBV is passed from mother to child (MTCT) during childbirth.<a href="#cite_note-WHO2022-1">[1]</a> Without intervention, a mother who is positive for <a href="/wiki/HBsAg" title="HBsAg">HBsAg</a> has a 20% risk of passing the infection to her offspring at the time of birth. This risk is as high as 90% if the mother is also positive for <a href="/wiki/HBeAg" title="HBeAg">HBeAg</a>.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] Early life horizontal transmission can occur through bites, lesions, certain sanitary habits, or other contact with secretions or saliva containing HBV.<a href="#cite_note-33">[33]</a><a href="#cite_note-34">[34]</a> Adult horizontal transmission is known to occur through <a href="/wiki/Sexual_intercourse" title="Sexual intercourse">sexual contact</a>,<a href="#cite_note-pmid22143117-35">[35]</a> <a href="/wiki/Blood_transfusion" title="Blood transfusion">blood transfusions</a> and transfusion with other human blood products,<a href="#cite_note-pmid18831300-36">[36]</a> <a href="/wiki/Needle_sharing" title="Needle sharing">re-use of contaminated needles</a> and syringes.<a href="#cite_note-pmid10729739-37">[37]</a> Breastfeeding after proper immunoprophylaxis does not appear to contribute to mother-to-child-transmission (MTCT) of HBV.<a href="#cite_note-pmid21536948-38">[38]</a> <div class="mw-heading mw-heading3"><h3 id="Virology">Virology</h3>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=4" title="Edit section: Virology">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">Hepatitis B virus</a></div> <div class="mw-heading mw-heading4"><h4 id="Structure">Structure</h4>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=5" title="Edit section: Structure">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HBV.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/HBV.png/220px-HBV.png" decoding="async" width="220" height="140" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/HBV.png/330px-HBV.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/78/HBV.png/440px-HBV.png 2x" data-file-width="711" data-file-height="452" /></a><figcaption>The structure of hepatitis B virus</figcaption></figure> Hepatitis B virus (HBV) is a member of the <a href="/wiki/Hepadnaviridae" title="Hepadnaviridae">hepadnavirus family</a>.<a href="#cite_note-Baron-39">[39]</a> The virus particle (<a href="/wiki/Virion" title="Virion">virion</a>) consists of an outer <a href="/wiki/Lipid" title="Lipid">lipid</a> envelope and an <a href="/wiki/Icosahedron" title="Icosahedron">icosahedral</a> <a href="/wiki/Nucleocapsid" class="mw-redirect" title="Nucleocapsid">nucleocapsid</a> core composed of core <a href="/wiki/Protein" title="Protein">protein</a>. These virions are 30–42 nm in diameter. The nucleocapsid encloses the viral DNA and a DNA polymerase that has <a href="/wiki/Reverse_transcriptase" title="Reverse transcriptase">reverse transcriptase</a> activity.<a href="#cite_note-pmid15192795-40">[40]</a> The outer envelope contains embedded proteins that are involved in viral binding of, and entry into, susceptible cells. The virus is one of the smallest enveloped animal viruses. The 42 nm virions, which are capable of infecting liver cells known as <a href="/wiki/Hepatocyte" title="Hepatocyte">hepatocytes</a>, are referred to as "Dane particles".<a href="#cite_note-41">[41]</a> In addition to the Dane particles, filamentous and spherical bodies lacking a core can be found in the serum of infected individuals.<a href="#cite_note-42">[42]</a> These particles are not infectious and are composed of the lipid and protein that forms part of the surface of the virion, which is called the surface antigens (<a href="/wiki/HBsAg" title="HBsAg">HBsAg</a>), and is produced in excess during the life cycle of the virus.<a href="#cite_note-pmid3014045-43">[43]</a> <div class="mw-heading mw-heading4"><h4 id="Genome">Genome</h4>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=6" title="Edit section: Genome">edit</a>]</div> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:HBV_Genome.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/HBV_Genome.svg/220px-HBV_Genome.svg.png" decoding="async" width="220" height="218" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/HBV_Genome.svg/330px-HBV_Genome.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/HBV_Genome.svg/440px-HBV_Genome.svg.png 2x" data-file-width="425" data-file-height="421" /></a><figcaption>The genome organisation of HBV. The genes overlap.</figcaption></figure> The <a href="/wiki/Genome" title="Genome">genome</a> of HBV is made of circular <a href="/wiki/DNA" title="DNA">DNA</a>, but it is unusual because the DNA is not fully <a href="/wiki/Double_helix" class="mw-redirect" title="Double helix">double-stranded</a>. One end of the full length strand is linked to the <a href="/wiki/Hepatitis_B_virus_DNA_polymerase" title="Hepatitis B virus DNA polymerase">HBV DNA polymerase</a>. The genome is 3020–3320 <a href="/wiki/Nucleotides" class="mw-redirect" title="Nucleotides">nucleotides</a> long (for the full-length strand) and 1700–2800 nucleotides long (for the short length-strand).<a href="#cite_note-44">[44]</a> The negative-sense (non-coding) is complementary to the viral <a href="/wiki/Messenger_RNA" title="Messenger RNA">mRNA</a>. The viral DNA is found in the <a href="/wiki/Nucleus_(biology)" class="mw-redirect" title="Nucleus (biology)">nucleus</a> soon after infection of the <a href="/wiki/Cell_(biology)" title="Cell (biology)">cell</a>. The partially double-stranded DNA is rendered fully double-stranded by completion of the (+) sense strand and removal of a <a href="/wiki/Protein" title="Protein">protein</a> <a href="/wiki/Molecule" title="Molecule">molecule</a> from the (−) sense strand and a short sequence of <a href="/wiki/RNA" title="RNA">RNA</a> from the (+) sense strand. Non-coding bases are removed from the ends of the (−) sense strand and the ends are rejoined. There are four known genes encoded by the genome, called C, X, P, and S. The core protein is coded for by gene C (HBcAg), and its start <a href="/wiki/Codon" class="mw-redirect" title="Codon">codon</a> is preceded by an upstream in-frame AUG start codon from which the pre-core protein is produced. HBeAg is produced by <a href="/wiki/Proteolysis" title="Proteolysis">proteolytic</a> processing of the pre-core protein. In some rare strains of the virus known as <a href="/wiki/Hepatitis_B_virus_precore_mutant" title="Hepatitis B virus precore mutant">hepatitis B virus precore mutants</a>, no HBeAg is present.<a href="#cite_note-pmid16461229-45">[45]</a> The DNA <a href="/wiki/Polymerase" title="Polymerase">polymerase</a> is encoded by gene P. Gene S is the gene that codes for the surface <a href="/wiki/Antigen" title="Antigen">antigen</a> (HBsAg). The HBsAg gene is one long <a href="/wiki/Open_reading_frame" title="Open reading frame">open reading frame</a> but contains three in frame "start" (ATG) codons that divide the gene into three sections, pre-S1, pre-S2, and S. Because of the multiple start codons, <a href="/wiki/Polypeptide" class="mw-redirect" title="Polypeptide">polypeptides</a> of three different sizes called large (the order from surface to the inside: pre-S1, pre-S2, and S ), middle (pre-S2, S), and small (S)<a href="#cite_note-46">[46]</a> are produced.<a href="#cite_note-pmid17206754-47">[47]</a> There is a myristyl group, which plays an important role in infection, on the amino-terminal end of the preS1 part of the large (L) protein.<a href="#cite_note-48">[48]</a> In addition to that, N terminus of the L protein have virus attachment and capsid binding sites. Because of that, the N termini of half of the L protein molecules are positioned outside the membrane and the other half positioned inside the membrane.<a href="#cite_note-49">[49]</a> The function of the protein coded for by gene X is not fully understood but it is associated with the development of liver cancer. It stimulates genes that promote cell growth and inactivates growth regulating molecules.<a href="#cite_note-50">[50]</a> <div class="mw-heading mw-heading4"><h4 id="Pathogenesis">Pathogenesis</h4>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=7" title="Edit section: Pathogenesis">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HBV_replication.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/HBV_replication.png/220px-HBV_replication.png" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/HBV_replication.png/330px-HBV_replication.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8c/HBV_replication.png/440px-HBV_replication.png 2x" data-file-width="960" data-file-height="720" /></a><figcaption>Hepatitis B virus replication</figcaption></figure> The life cycle of hepatitis B virus is complex. Hepatitis B is one of a few known <a href="/wiki/Pararetrovirus" class="mw-redirect" title="Pararetrovirus">pararetroviruses</a>: non-<a href="/wiki/Retrovirus" title="Retrovirus">retroviruses</a> that still use <a href="/wiki/Reverse_transcription" class="mw-redirect" title="Reverse transcription">reverse transcription</a> in their replication process. The virus gains entry into the cell by binding to <a href="/wiki/SLC10A1" class="mw-redirect" title="SLC10A1">NTCP</a><a href="#cite_note-pmid23150796-51">[51]</a> on the surface and being <a href="/wiki/Endocytosis" title="Endocytosis">endocytosed</a>. Because the virus multiplies via RNA made by a host enzyme, the viral genomic DNA has to be transferred to the cell nucleus by host proteins called chaperones. The partially double-stranded, circular viral DNA is then made fully double stranded by HBV DNA polymerase, transforming the genome into <a href="/wiki/CccDNA" title="CccDNA">covalently closed circular DNA</a> (cccDNA). This cccDNA serves as a template for transcription of four viral <a href="/wiki/MRNA" class="mw-redirect" title="MRNA">mRNAs</a> by host RNA polymerase. The largest mRNA, (which is longer than the viral genome), is used to make the new copies of the genome and to make the <a href="/wiki/Capsid" title="Capsid">capsid</a> core protein and the viral <a href="/wiki/DNA_polymerase" title="DNA polymerase">DNA polymerase</a>. These four viral transcripts undergo additional processing and go on to form progeny virions that are released from the cell or returned to the nucleus and re-cycled to produce even more copies.<a href="#cite_note-pmid17206754-47">[47]</a><a href="#cite_note-pmid17206755-52">[52]</a> The long mRNA is then transported back to the cytoplasm where the virion P protein (the DNA polymerase) synthesizes DNA via its reverse transcriptase activity. <div class="mw-heading mw-heading4"><h4 id="Serotypes_and_genotypes">Serotypes and genotypes</h4>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=8" title="Edit section: Serotypes and genotypes">edit</a>]</div> The virus is divided into four major <a href="/wiki/Serotype" title="Serotype">serotypes</a> (adr, adw, ayr, ayw) based on antigenic <a href="/wiki/Epitope" title="Epitope">epitopes</a> presented on its envelope proteins, and into eight major genotypes (A–H). The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.<a href="#cite_note-pmid15752827-53">[53]</a><a href="#cite_note-pmid8666521-54">[54]</a> There are two other genotypes I and J but they are not universally accepted as of 2015.<a href="#cite_note-55">[55]</a> The diversity of genotypes is not shown equally in the world. For example, A, D, and E genotypes have been seen in Africa prevalently while B and C genotypes are observed in Asia as widespread.<a href="#cite_note-56">[56]</a> Genotypes differ by at least 8% of their sequence and were first reported in 1988 when six were initially described (A–F).<a href="#cite_note-Norder1994-57">[57]</a> Two further types have since been described (G and H).<a href="#cite_note-pmid15779062-58">[58]</a> Most genotypes are now divided into subgenotypes with distinct properties.<a href="#cite_note-pmid17206751-59">[59]</a> <div class="mw-heading mw-heading2"><h2 id="Mechanisms">Mechanisms</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=9" title="Edit section: Mechanisms">edit</a>]</div> Hepatitis B virus primarily interferes with the functions of the liver by replicating in <a href="/wiki/Hepatocytes" class="mw-redirect" title="Hepatocytes">hepatocytes</a>. A functional <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptor</a> is <a href="/wiki/SLC10A1" class="mw-redirect" title="SLC10A1">NTCP</a>.<a href="#cite_note-pmid23150796-51">[51]</a> There is evidence that the receptor in the closely related <a href="/wiki/Duck_hepatitis_B_virus" title="Duck hepatitis B virus">duck hepatitis B virus</a> is <a href="/wiki/Carboxypeptidase_D" title="Carboxypeptidase D">carboxypeptidase D</a>.<a href="#cite_note-pmid10482623-60">[60]</a><a href="#cite_note-pmid17206752-61">[61]</a> The virions bind to the host cell via the preS domain of the viral surface antigen and are subsequently internalized by endocytosis. HBV-preS-specific receptors are expressed primarily on hepatocytes; however, viral DNA and proteins have also been detected in extrahepatic sites, suggesting that cellular receptors for HBV may also exist on extrahepatic cells.<a href="#cite_note-pmid21462295-62">[62]</a> During HBV infection, the host <a href="/wiki/Immune_response" title="Immune response">immune response</a> causes both hepatocellular damage and viral clearance. Although the innate immune response does not play a significant role in these processes, the adaptive immune response, in particular virus-specific <a href="/wiki/Cytotoxic_T_lymphocytes" class="mw-redirect" title="Cytotoxic T lymphocytes">cytotoxic T lymphocytes</a>(CTLs), contributes to most of the liver injury associated with HBV infection. CTLs eliminate HBV infection by killing infected cells and producing antiviral <a href="/wiki/Cytokine" title="Cytokine">cytokines</a>, which are then used to purge HBV from viable hepatocytes.<a href="#cite_note-Iannacone_2007-63">[63]</a> Although liver damage is initiated and mediated by the CTLs, <a href="/wiki/Antigen" title="Antigen">antigen</a>-nonspecific <a href="/wiki/Inflammatory_cell" class="mw-redirect" title="Inflammatory cell">inflammatory cells</a> can worsen CTL-induced immunopathology, and <a href="/wiki/Platelets" class="mw-redirect" title="Platelets">platelets</a> activated at the site of infection may facilitate the accumulation of CTLs in the liver.<a href="#cite_note-Iannacone_2005-64">[64]</a> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=10" title="Edit section: Diagnosis">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1273380762/mw-parser-output/.tmulti">.mw-parser-output .tmulti .multiimageinner{display:flex;flex-direction:column}.mw-parser-output .tmulti .trow{display:flex;flex-direction:row;clear:left;flex-wrap:wrap;width:100%;box-sizing:border-box}.mw-parser-output .tmulti .tsingle{margin:1px;float:left}.mw-parser-output .tmulti .theader{clear:both;font-weight:bold;text-align:center;align-self:center;background-color:transparent;width:100%}.mw-parser-output .tmulti .thumbcaption{background-color:transparent}.mw-parser-output .tmulti .text-align-left{text-align:left}.mw-parser-output .tmulti .text-align-right{text-align:right}.mw-parser-output .tmulti .text-align-center{text-align:center}@media all and (max-width:720px){.mw-parser-output .tmulti .thumbinner{width:100%!important;box-sizing:border-box;max-width:none!important;align-items:center}.mw-parser-output .tmulti .trow{justify-content:center}.mw-parser-output .tmulti .tsingle{float:none!important;max-width:100%!important;box-sizing:border-box;text-align:center}.mw-parser-output .tmulti .tsingle .thumbcaption{text-align:left}.mw-parser-output .tmulti .trow>.thumbcaption{text-align:center}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .tmulti .multiimageinner span:not(.skin-invert-image):not(.skin-invert):not(.bg-transparent) img{background-color:white}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .tmulti .multiimageinner span:not(.skin-invert-image):not(.skin-invert):not(.bg-transparent) img{background-color:white}}</style><div class="thumb tmulti tright"><div class="thumbinner multiimageinner" style="width:204px;max-width:204px"><div class="trow"><div class="tsingle" style="width:202px;max-width:202px"><div class="thumbimage"><a href="/wiki/File:HBV_serum_markers.png" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/HBV_serum_markers.png/200px-HBV_serum_markers.png" decoding="async" width="200" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/HBV_serum_markers.png/300px-HBV_serum_markers.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/HBV_serum_markers.png/400px-HBV_serum_markers.png 2x" data-file-width="637" data-file-height="524" /></a></div><div class="thumbcaption">Hepatitis B viral antigens and antibodies detectable in the blood following acute infection</div></div></div><div class="trow"><div class="tsingle" style="width:202px;max-width:202px"><div class="thumbimage"><a href="/wiki/File:Chronic_HBV_Diagram-Vector.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Chronic_HBV_Diagram-Vector.svg/200px-Chronic_HBV_Diagram-Vector.svg.png" decoding="async" width="200" height="103" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Chronic_HBV_Diagram-Vector.svg/300px-Chronic_HBV_Diagram-Vector.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Chronic_HBV_Diagram-Vector.svg/400px-Chronic_HBV_Diagram-Vector.svg.png 2x" data-file-width="1311" data-file-height="673" /></a></div><div class="thumbcaption">Hepatitis B viral antigens and antibodies detectable in the blood of a chronically infected person</div></div></div></div></div> The tests, called <a href="/wiki/Assay" title="Assay">assays</a>, for detection of hepatitis B virus infection involve <a href="/wiki/Serum_(blood)" title="Serum (blood)">serum</a> or <a href="/wiki/Blood_test" title="Blood test">blood tests</a> that detect either viral antigens (proteins produced by the virus) or <a href="/wiki/Antibody" title="Antibody">antibodies</a> produced by the host. Interpretation of these assays is complex.<a href="#cite_note-pmid3331068-65">[65]</a> The hepatitis B surface antigen (<a href="/wiki/HBsAg" title="HBsAg">HBsAg</a>) is most frequently used to screen for the presence of this infection. It is the first detectable viral antigen to appear during infection. However, early in an infection, this antigen may not be present and it may be undetectable later in the infection as it is being cleared by the host. The infectious virion contains an inner "core particle" enclosing viral genome. The icosahedral core particle is made of 180 or 240 copies of the core protein, alternatively known as hepatitis B core antigen, or <a href="/wiki/HBcAg" title="HBcAg">HBcAg</a>. During this 'window' in which the host remains infected but is successfully clearing the virus, <a href="/wiki/IgM" class="mw-redirect" title="IgM">IgM</a> antibodies specific to the hepatitis B core antigen (anti-HBc IgM) may be the only serological evidence of disease. Therefore, most hepatitis B diagnostic panels contain HBsAg and total anti-HBc (both IgM and IgG).<a href="#cite_note-isbn0-12-375147-0-66">[66]</a> Shortly after the appearance of the HBsAg, another antigen called hepatitis B e antigen (<a href="/wiki/HBeAg" title="HBeAg">HBeAg</a>) will appear. Traditionally, the presence of HBeAg in a host's serum is associated with much higher rates of viral replication and enhanced infectivity; however, variants of the hepatitis B virus do not produce the 'e' antigen, so this rule does not always hold true.<a href="#cite_note-Liaw2010-67">[67]</a> During the natural course of an infection, the HBeAg may be cleared, and antibodies to the 'e' antigen (anti-HBe) will arise immediately afterwards. This conversion is usually associated with a dramatic decline in viral replication. <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Ground_glass_hepatocytes_high_mag_cropped.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ground_glass_hepatocytes_high_mag_cropped.jpg/220px-Ground_glass_hepatocytes_high_mag_cropped.jpg" decoding="async" width="220" height="149" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ground_glass_hepatocytes_high_mag_cropped.jpg/330px-Ground_glass_hepatocytes_high_mag_cropped.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ground_glass_hepatocytes_high_mag_cropped.jpg/440px-Ground_glass_hepatocytes_high_mag_cropped.jpg 2x" data-file-width="1269" data-file-height="858" /></a><figcaption><a href="/wiki/Ground_glass_hepatocytes" class="mw-redirect" title="Ground glass hepatocytes">Ground glass hepatocytes</a> as seen in a chronic hepatitis B <a href="/wiki/Liver" title="Liver">liver</a> <a href="/wiki/Biopsy" title="Biopsy">biopsy</a>. <a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a></figcaption></figure> If the host is able to clear the infection, eventually the HBsAg will become undetectable and will be followed by <a href="/wiki/Immunoglobulin_G" title="Immunoglobulin G">IgG</a> antibodies to the hepatitis B surface antigen and core antigen (anti-HBs and anti HBc IgG).<a href="#cite_note-Baron-39">[39]</a> The time between the removal of the HBsAg and the appearance of anti-HBs is called the <a href="/wiki/Window_period" title="Window period">window period</a>. A person negative for HBsAg but positive for anti-HBs either has cleared an infection or has been vaccinated previously. Individuals who remain HBsAg positive for at least six months are considered to be hepatitis B carriers.<a href="#cite_note-pmid17256718-68">[68]</a> Carriers of the virus may have chronic hepatitis B, which would be reflected by elevated serum <a href="/wiki/Alanine_aminotransferase" class="mw-redirect" title="Alanine aminotransferase">alanine aminotransferase</a> (ALT) levels and inflammation of the liver, if they are in the immune clearance phase of chronic infection. Carriers who have seroconverted to HBeAg negative status, in particular those who acquired the infection as adults, have very little viral multiplication and hence may be at little risk of long-term complications or of transmitting infection to others.<a href="#cite_note-pmid17935720-69">[69]</a> However, it is possible for individuals to enter an "immune escape" with HBeAg-negative hepatitis. <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Hepatitis_B_virus_phases_of_chronic_infection.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/Hepatitis_B_virus_phases_of_chronic_infection.png/220px-Hepatitis_B_virus_phases_of_chronic_infection.png" decoding="async" width="220" height="151" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/Hepatitis_B_virus_phases_of_chronic_infection.png/330px-Hepatitis_B_virus_phases_of_chronic_infection.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/90/Hepatitis_B_virus_phases_of_chronic_infection.png/440px-Hepatitis_B_virus_phases_of_chronic_infection.png 2x" data-file-width="4096" data-file-height="2816" /></a><figcaption>The five phases of chronic hepatitis B infection as defined by <a href="/wiki/European_Association_for_the_Study_of_the_Liver" title="European Association for the Study of the Liver">European Association for the Study of the Liver</a></figcaption></figure> <a href="/wiki/Polymerase_chain_reaction" title="Polymerase chain reaction">PCR</a> tests have been developed to detect and measure the amount of HBV DNA, called the <a href="/wiki/Viral_load" title="Viral load">viral load</a>, in clinical specimens. These tests are used to assess a person's infection status and to monitor treatment.<a href="#cite_note-pmid17051445-70">[70]</a> Individuals with high <a href="/wiki/Viral_load" title="Viral load">viral loads</a>, characteristically have <a href="/wiki/Ground_glass_hepatocyte" title="Ground glass hepatocyte">ground glass hepatocytes</a> on biopsy. <div class="mw-heading mw-heading2"><h2 id="Prevention">Prevention</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=11" title="Edit section: Prevention">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Vaccine">Vaccine</h3>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=12" title="Edit section: Vaccine">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">Hepatitis B vaccine</a></div> Vaccines for the prevention of hepatitis B have been routinely recommended for babies since 1991 in the United States.<a href="#cite_note-CDC2013-71">[71]</a> The first dose is generally recommended within a day of birth.<a href="#cite_note-72">[72]</a> The hepatitis B vaccine was the first vaccine capable of preventing cancer, specifically liver cancer.<a href="#cite_note-73">[73]</a> Most vaccines are given in three doses over a course of days. A protective response to the vaccine is defined as an anti-HBs antibody concentration of at least 10 mIU/ml in the recipient's serum. The vaccine is more effective in children and 95 percent of those vaccinated have protective levels of antibody. This drops to around 90% at 40 years of age and to around 75 percent in those over 60 years. The protection afforded by vaccination is long lasting even after antibody levels fall below 10 mIU/ml. For newborns of HBsAg-positive mothers: hepatitis B vaccine alone, hepatitis B immunoglobulin alone, or the combination of vaccine plus hepatitis B immunoglobulin, all prevent hepatitis B occurrence.<a href="#cite_note-Lee2006-74">[74]</a> Furthermore, the combination of vaccine plus hepatitis B immunoglobulin is superior to vaccine alone.<a href="#cite_note-Lee2006-74">[74]</a> This combination prevents HBV transmission around the time of birth in 86% to 99% of cases.<a href="#cite_note-75">[75]</a> <a href="/wiki/Tenofovir" class="mw-redirect" title="Tenofovir">Tenofovir</a> given in the second or third trimester can reduce the risk of mother to child transmission by 77% when combined with hepatitis B immunoglobulin and the hepatitis B vaccine, especially for pregnant women with high hepatitis B virus DNA levels.<a href="#cite_note-76">[76]</a> However, there is not sufficient evidence that the administration of hepatitis B immunoglobulin alone during pregnancy, might reduce transmission rates to the newborn infant.<a href="#cite_note-77">[77]</a> No randomized control trial has been conducted to assess the effects of hepatitis B vaccine during pregnancy for preventing infant infection.<a href="#cite_note-78">[78]</a> All those with a risk of exposure to body fluids such as blood should be vaccinated, if not already.<a href="#cite_note-CDC2013-71">[71]</a> Testing to verify effective immunization is recommended and further doses of vaccine are given to those who are not sufficiently immunized.<a href="#cite_note-CDC2013-71">[71]</a> In 10- to 22-year follow-up studies there were no cases of hepatitis B among those with a normal immune system who were vaccinated. Only rare chronic infections have been documented.<a href="#cite_note-79">[79]</a> Vaccination is particularly recommended for high risk groups including: health workers, people with chronic <a href="/wiki/Kidney_failure" title="Kidney failure">kidney failure</a>, and men who have sex with men.<a href="#cite_note-Chen2005-80">[80]</a><a href="#cite_note-Schr2004-81">[81]</a><a href="#cite_note-82">[82]</a> Both types of the hepatitis B vaccine, the plasma-derived vaccine (PDV) and the recombinant vaccine (RV) are of similar effectiveness in preventing infection in both healthcare workers and chronic kidney failure groups.<a href="#cite_note-Chen2005-80">[80]</a><a href="#cite_note-Schr2004-81">[81]</a> One difference was noticed among the health worker group: the RV intramuscular route was significantly more effective compared with the RV intradermal route of administration.<a href="#cite_note-Chen2005-80">[80]</a> <div class="mw-heading mw-heading3"><h3 id="Other">Other</h3>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=13" title="Edit section: Other">edit</a>]</div> In <a href="/wiki/Assisted_reproductive_technology" title="Assisted reproductive technology">assisted reproductive technology</a>, <a href="/wiki/Sperm_washing" title="Sperm washing">sperm washing</a> is not necessary for males with hepatitis B to prevent transmission, unless the female partner has not been effectively vaccinated.<a href="#cite_note-Lutgens2009-83">[83]</a> In females with hepatitis B, the risk of transmission from mother to child with IVF is no different from the risk in spontaneous conception.<a href="#cite_note-Lutgens2009-83">[83]</a> Those at high risk of infection should be tested as there is effective treatment for those who have the disease.<a href="#cite_note-LeF2014-84">[84]</a> Groups that screening is recommended for include those who have not been vaccinated and one of the following: people from areas of the world where hepatitis B occurs in more than 2%, those with HIV, intravenous drug users, men who have sex with men, and those who live with someone with hepatitis B.<a href="#cite_note-LeF2014-84">[84]</a> Screening during <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a> is recommended in the United States.<a href="#cite_note-85">[85]</a> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=14" title="Edit section: Treatment">edit</a>]</div> Acute hepatitis B infection does not usually require treatment and most adults clear the infection spontaneously.<a href="#cite_note-pmid17129820-86">[86]</a><a href="#cite_note-87">[87]</a> Early antiviral treatment may be required in fewer than 1% of people, whose infection takes a very aggressive course (fulminant hepatitis) or who are <a href="/wiki/Immunocompromised" class="mw-redirect" title="Immunocompromised">immunocompromised</a>. On the other hand, treatment of chronic infection may be necessary to reduce the risk of <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a> and liver cancer. Chronically infected individuals with persistently elevated serum <a href="/wiki/Alanine_aminotransferase" class="mw-redirect" title="Alanine aminotransferase">alanine aminotransferase</a>, a marker of liver damage, and HBV DNA levels are candidates for therapy.<a href="#cite_note-pmid17606962-88">[88]</a> Treatment lasts from six months to a year, depending on medication and genotype.<a href="#cite_note-pmid21195373-89">[89]</a> Treatment duration when medication is taken by mouth, however, is more variable and usually longer than one year.<a href="#cite_note-90">[90]</a> Although none of the available medications can clear the infection, they can stop the virus from replicating, thus minimizing liver damage. As of 2024, there are seven medications licensed for the treatment of hepatitis B infection in the United States.<a href="#cite_note-91">[91]</a> These include <a href="/wiki/Antiviral_drug" title="Antiviral drug">antiviral</a> medications <a href="/wiki/Lamivudine" title="Lamivudine">lamivudine</a>, <a href="/wiki/Adefovir" title="Adefovir">adefovir</a>, <a href="/wiki/Tenofovir_disoproxil" title="Tenofovir disoproxil">tenofovir disoproxil</a>, <a href="/wiki/Tenofovir_alafenamide" title="Tenofovir alafenamide">tenofovir alafenamide</a>, <a href="/wiki/Telbivudine" title="Telbivudine">telbivudine</a>, and <a href="/wiki/Entecavir" title="Entecavir">entecavir</a>, and the two <a href="/wiki/Immune_system" title="Immune system">immune system</a> modulators <a href="/wiki/Interferon" title="Interferon">interferon alpha-2a</a> and <a href="/wiki/Peginterferon_alfa-2a" title="Peginterferon alfa-2a">PEGylated interferon alpha-2a</a>. In 2015, the World Health Organization recommended tenofovir or entecavir as first-line agents.<a href="#cite_note-WHO2015Book-92">[92]</a> Those with current cirrhosis are in most need of treatment.<a href="#cite_note-WHO2015Book-92">[92]</a> The use of interferon, which requires injections daily or thrice weekly, has been supplanted by long-acting <a href="/wiki/PEGylation" title="PEGylation">PEGylated</a> <a href="/wiki/Interferon" title="Interferon">interferon</a>, which is injected only once weekly.<a href="#cite_note-Dienstag-93">[93]</a> However, some individuals are much more likely to respond than others, and this might be because of the <a href="/wiki/Genotype" title="Genotype">genotype</a> of the infecting virus or the person's heredity. The treatment reduces viral replication in the liver, thereby reducing the <a href="/wiki/Viral_load" title="Viral load">viral load</a> (the amount of virus particles as measured in the blood).<a href="#cite_note-pmid12000599-94">[94]</a> Response to treatment differs between the genotypes. <a href="/wiki/Interferon" title="Interferon">Interferon</a> treatment may produce an e antigen seroconversion rate of 37% in genotype A but only a 6% seroconversion in type D. Genotype B has similar seroconversion rates to type A while type C seroconverts only in 15% of cases. Sustained e antigen loss after treatment is ~45% in types A and B but only 25–30% in types C and D.<a href="#cite_note-pmid19998495-95">[95]</a> It seems unlikely that the disease will be eliminated by 2030, the goal set in 2016 by WHO. However, progress is being made in developing therapeutic treatments. In 2010, the Hepatitis B Foundation reported that 3 preclinical and 11 clinical-stage drugs were under development, based on largely similar mechanisms. In 2020, they reported that there were 17 preclinical- and 32 clinical-stage drugs under development, using diverse mechanisms.<a href="#cite_note-Block-15">[15]</a> <div class="mw-heading mw-heading2"><h2 id="Prognosis">Prognosis</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=15" title="Edit section: Prognosis">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Hepatitis_B_world_map_-_DALY_-_WHO2004.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/74/Hepatitis_B_world_map_-_DALY_-_WHO2004.svg/290px-Hepatitis_B_world_map_-_DALY_-_WHO2004.svg.png" decoding="async" width="290" height="128" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/74/Hepatitis_B_world_map_-_DALY_-_WHO2004.svg/435px-Hepatitis_B_world_map_-_DALY_-_WHO2004.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/74/Hepatitis_B_world_map_-_DALY_-_WHO2004.svg/580px-Hepatitis_B_world_map_-_DALY_-_WHO2004.svg.png 2x" data-file-width="940" data-file-height="415" /></a><figcaption>Estimate of <a href="/wiki/Disability-adjusted_life_year" title="Disability-adjusted life year">disability-adjusted life year</a> for hepatitis B per 100,000 inhabitants as of 2004 <style data-mw-deduplicate="TemplateStyles:r1216972533">.mw-parser-output .col-begin{border-collapse:collapse;padding:0;color:inherit;width:100%;border:0;margin:0}.mw-parser-output .col-begin-small{font-size:90%}.mw-parser-output .col-break{vertical-align:top;text-align:left}.mw-parser-output .col-break-2{width:50%}.mw-parser-output .col-break-3{width:33.3%}.mw-parser-output .col-break-4{width:25%}.mw-parser-output .col-break-5{width:20%}@media(max-width:720px){.mw-parser-output .col-begin,.mw-parser-output .col-begin>tbody,.mw-parser-output .col-begin>tbody>tr,.mw-parser-output .col-begin>tbody>tr>td{display:block!important;width:100%!important}.mw-parser-output .col-break{padding-left:0!important}}</style><div> <table class="col-begin" role="presentation"> <tbody><tr> <td class="col-break"> <style data-mw-deduplicate="TemplateStyles:r981673959">.mw-parser-output .legend{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .legend-color{display:inline-block;min-width:1.25em;height:1.25em;line-height:1.25;margin:1px 0;text-align:center;border:1px solid black;background-color:transparent;color:black}.mw-parser-output .legend-text{}</style><div class="legend">  no data</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  <10</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  10–20</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  20–40</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  40–60</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  60–80</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  80–100</div> </td> <td class="col-break"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  100–125</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  125–150</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  150–200</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  200–250</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  250–500</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend">  >500</div> </td></tr></tbody></table></div> </figcaption></figure> Hepatitis B virus infection may be either acute (self-limiting) or chronic (long-standing). Persons with self-limiting infection clear the infection spontaneously within weeks to months. Children are less likely than adults to clear the infection. More than 95% of people who become infected as adults or older children will stage a full recovery and develop protective immunity to the virus. However, this drops to 30% for younger children, and only 5% of newborns that acquire the infection from their mother at birth will clear the infection.<a href="#cite_note-96">[96]</a> This population has a 40% lifetime risk of death from <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a> or <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">hepatocellular carcinoma</a>.<a href="#cite_note-Dienstag-93">[93]</a> Of those infected between the age of one to six, 70% will clear the infection.<a href="#cite_note-pmid16176431-97">[97]</a> <a href="/wiki/Hepatitis_D" title="Hepatitis D">Hepatitis D</a> (HDV) can occur only with a concomitant hepatitis B infection, because HDV uses the HBV surface antigen to form a <a href="/wiki/Capsid" title="Capsid">capsid</a>.<a href="#cite_note-pmid16364738-98">[98]</a> Co-infection with hepatitis D increases the risk of liver cirrhosis and liver cancer.<a href="#cite_note-pmid1661197-99">[99]</a> <a href="/wiki/Polyarteritis_nodosa" title="Polyarteritis nodosa">Polyarteritis nodosa</a> is more common in people with hepatitis B infection. <div class="mw-heading mw-heading3"><h3 id="Cirrhosis">Cirrhosis</h3>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=16" title="Edit section: Cirrhosis">edit</a>]</div> A number of different tests are available to determine the degree of cirrhosis present. <a href="/wiki/Transient_elastography" class="mw-redirect" title="Transient elastography">Transient elastography</a> (FibroScan) is the test of choice, but it is expensive.<a href="#cite_note-WHO2015Book-92">[92]</a> <a href="/w/index.php?title=Aspartate_aminotransferase_to_platelet_ratio_index&action=edit&redlink=1" class="new" title="Aspartate aminotransferase to platelet ratio index (page does not exist)">Aspartate aminotransferase to platelet ratio index</a> may be used when cost is an issue.<a href="#cite_note-WHO2015Book-92">[92]</a> <div class="mw-heading mw-heading3"><h3 id="Reactivation">Reactivation</h3>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=17" title="Edit section: Reactivation">edit</a>]</div> Hepatitis B virus DNA remains in the body after infection, and in some people, including those that do not have detectable HBsAg, the disease recurs.<a href="#cite_note-pmid30641484-100">[100]</a><a href="#cite_note-pmid17981227-101">[101]</a> Although rare, reactivation is seen most often following alcohol or drug use,<a href="#cite_note-pmid21195374-102">[102]</a> or in people with impaired immunity.<a href="#cite_note-pmid18184191-103">[103]</a> HBV goes through cycles of replication and non-replication. Approximately 50% of overt carriers experience acute reactivation. Males with baseline ALT of 200 UL/L are three times more likely to develop a reactivation than people with lower levels. Although reactivation can occur spontaneously,<a href="#cite_note-pmid21205146-104">[104]</a> people who undergo <a href="/wiki/Chemotherapy" title="Chemotherapy">chemotherapy</a> have a higher risk.<a href="#cite_note-pmid22025876-105">[105]</a> <a href="/wiki/Immunosuppressive_drugs" class="mw-redirect" title="Immunosuppressive drugs">Immunosuppressive drugs</a> favor increased HBV replication while inhibiting <a href="/wiki/Cytotoxic_T_cell" title="Cytotoxic T cell">cytotoxic T cell</a> function in the liver.<a href="#cite_note-106">[106]</a> The risk of reactivation varies depending on the serological profile; those with detectable HBsAg in their blood are at the greatest risk, but those with only antibodies to the core antigen are also at risk. The presence of antibodies to the surface antigen, which are considered to be a marker of immunity, does not preclude reactivation.<a href="#cite_note-pmid22025876-105">[105]</a> Treatment with prophylactic antiviral drugs can prevent the serious morbidity associated with HBV disease reactivation.<a href="#cite_note-pmid22025876-105">[105]</a> <div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=18" title="Edit section: Epidemiology">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Hepatitis_B_incidence_rate,_OWID.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Hepatitis_B_incidence_rate%2C_OWID.svg/350px-Hepatitis_B_incidence_rate%2C_OWID.svg.png" decoding="async" width="350" height="247" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Hepatitis_B_incidence_rate%2C_OWID.svg/525px-Hepatitis_B_incidence_rate%2C_OWID.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Hepatitis_B_incidence_rate%2C_OWID.svg/700px-Hepatitis_B_incidence_rate%2C_OWID.svg.png 2x" data-file-width="850" data-file-height="600" /></a><figcaption>Hepatitis B incidence rate in 2017.<a href="#cite_note-107">[107]</a></figcaption></figure> Approximately 254 million people had chronic HBV infection as of 2022. Another 1.2 million cases of acute HBV infection also occurred that year.<a href="#cite_note-108">[108]</a> Regional prevalences across the globe range from around 7.5% in Africa to 0.5% in the Americas.<a href="#cite_note-WHOProgress2021-19">[19]</a> The primary method of HBV transmission and the prevalence of chronic HBV infection in specific regions often correspond with one another. In populations where HBV infection rates are 8% or higher, which are classified as high prevalence, vertical transmission (usually occurring during birth) is most common, though rates of early childhood transmission can also be significant among these populations.<a href="#cite_note-MacLachlanCowie-109">[109]</a> In 2021, 19 African countries had infection rates ranging between 8-19%, placing them in the high prevalence category.<a href="#cite_note-Scorecard2021-110">[110]</a> High prevalence of HBV also exists in <a href="/wiki/Mongolia" title="Mongolia">Mongolia</a>.<a href="#cite_note-111">[111]</a><a href="#cite_note-112">[112]</a> In moderate prevalence areas where 2–7% of the population is chronically infected, the disease is predominantly spread horizontally, often among children, but also vertically.<a href="#cite_note-pmid12616449-113">[113]</a> China's HBV infection rate is at the higher end of the moderate prevalence classification with an infection rate of 6.89% as of 2019.<a href="#cite_note-114">[114]</a> HBV prevalence in India is also moderate, with studies placing India's infection rate between 2-4%.<a href="#cite_note-115">[115]</a> Countries with low HBV prevalence include Australia (0.9%),<a href="#cite_note-116">[116]</a> those in the WHO European Region (which average 1.5%),<a href="#cite_note-WHOProgress2021-19">[19]</a> and most countries in North and South America (which average 0.28%).<a href="#cite_note-117">[117]</a><a href="#cite_note-118">[118]</a> In the United States, an estimated 0.26% of the population was living with HBV infection as of 2018.<a href="#cite_note-119">[119]</a> <div class="mw-heading mw-heading2"><h2 id="History">History</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=19" title="Edit section: History">edit</a>]</div> Findings of HBV DNA in ancient human remains have shown that HBV has infected humans for at least ten millennia, both in Eurasia and in the Americas.<a href="#cite_note-:0-120">[120]</a><a href="#cite_note-:1-121">[121]</a><a href="#cite_note-twp-122">[122]</a> This disproved the belief that hepatitis B originated in the New World and spread to Europe around 16th century.<a href="#cite_note-twp-122">[122]</a> Hepatitis B virus subgenotype C4 is exclusively present in Australian aborigines, suggesting an ancient origin as much as 50,000 years old.<a href="#cite_note-123">[123]</a><a href="#cite_note-124">[124]</a><a href="#cite_note-125">[125]</a> However, analyses of ancient HBV genomes suggested that the most recent common ancestor of all known human HBV strains was dated to between 20,000 and 12,000 years ago,<a href="#cite_note-:0-120">[120]</a> pointing to a more recent origin for all HBV genotypes. The evolution of HBV in humans was shown to reflect known events of human history such as the first peopling of the Americas during the late Pleistocene and the Neolithic transition in Europe.<a href="#cite_note-:0-120">[120]</a> Ancient DNA studies have also showed that some ancient hepatitis viral <a href="/wiki/Strain_(biology)" title="Strain (biology)">strains</a> still infect humans, while other strains became extinct.<a href="#cite_note-:0-120">[120]</a><a href="#cite_note-:1-121">[121]</a> The earliest record of an epidemic caused by hepatitis B virus was made by Lurman in 1885.<a href="#cite_note-126">[126]</a> An outbreak of <a href="/wiki/Smallpox" title="Smallpox">smallpox</a> occurred in <a href="/wiki/Bremen" title="Bremen">Bremen</a> in 1883 and 1,289 shipyard employees were <a href="/wiki/Vaccinated" class="mw-redirect" title="Vaccinated">vaccinated</a> with <a href="/wiki/Lymph" title="Lymph">lymph</a> from other people. After several weeks, and up to eight months later, 191 of the vaccinated workers became ill with <a href="/wiki/Jaundice" title="Jaundice">jaundice</a> and were diagnosed with serum hepatitis. Other employees who had been inoculated with different batches of lymph remained healthy. Lurman's paper, now regarded as a classical example of an <a href="/wiki/Epidemiology" title="Epidemiology">epidemiological</a> study, proved that contaminated lymph was the source of the outbreak. Later, numerous similar outbreaks were reported following the introduction, in 1909, of <a href="/wiki/Hypodermic_needles" class="mw-redirect" title="Hypodermic needles">hypodermic needles</a> that were used, and, more importantly, reused, for administering <a href="/wiki/Arsphenamine" title="Arsphenamine">Salvarsan</a> for the treatment of <a href="/wiki/Syphilis" title="Syphilis">syphilis</a>. The largest recorded outbreak of hepatitis B was the infection of up to 330,000 American soldiers during World War II. The outbreak has been blamed on a yellow fever vaccine made with contaminated human blood serum, and after receiving the vaccinations about 50,000 soldiers developed jaundice.<a href="#cite_note-127">[127]</a> The virus was not discovered until 1966 when <a href="/wiki/Baruch_Blumberg" class="mw-redirect" title="Baruch Blumberg">Baruch Blumberg</a>, then working at the <a href="/wiki/National_Institutes_of_Health" title="National Institutes of Health">National Institutes of Health</a> (NIH), discovered the <a href="/wiki/HBsAg" title="HBsAg">Australia antigen</a> (later known to be hepatitis B surface antigen, or HBsAg) in the blood of Aboriginal Australian people.<a href="#cite_note-pmid5930797-128">[128]</a> Although a virus had been suspected since the research published by Frederick MacCallum in 1947,<a href="#cite_note-129">[129]</a> <a href="/wiki/David_Dane" title="David Dane">David Dane</a> and others discovered the virus particle in 1970 by <a href="/wiki/Electron_microscopy" class="mw-redirect" title="Electron microscopy">electron microscopy</a>.<a href="#cite_note-pmid4190997-130">[130]</a> In 1971, the FDA issued its first-ever blood supply screening order to blood banks.<a href="#cite_note-hepborg-131">[131]</a> By the early 1980s the <a href="/wiki/Genome" title="Genome">genome</a> of the virus had been sequenced,<a href="#cite_note-132">[132]</a> and the first vaccines were being tested.<a href="#cite_note-pmid6108398-133">[133]</a> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=20" title="Edit section: Society and culture">edit</a>]</div> <a href="/wiki/World_Hepatitis_Day" title="World Hepatitis Day">World Hepatitis Day</a>, observed 28 July, aims to raise global awareness of hepatitis B and <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a> and encourage prevention, diagnosis, and treatment. It has been led by the World Hepatitis Alliance since 2007 and in May 2010, it received global endorsement from the <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a>.<a href="#cite_note-134">[134]</a> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=21" title="Edit section: See also">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1266661725">.mw-parser-output .portalbox{padding:0;margin:0.5em 0;display:table;box-sizing:border-box;max-width:175px;list-style:none}.mw-parser-output .portalborder{border:1px solid var(--border-color-base,#a2a9b1);padding:0.1em;background:var(--background-color-neutral-subtle,#f8f9fa)}.mw-parser-output .portalbox-entry{display:table-row;font-size:85%;line-height:110%;height:1.9em;font-style:italic;font-weight:bold}.mw-parser-output .portalbox-image{display:table-cell;padding:0.2em;vertical-align:middle;text-align:center}.mw-parser-output .portalbox-link{display:table-cell;padding:0.2em 0.2em 0.2em 0.3em;vertical-align:middle}@media(min-width:720px){.mw-parser-output .portalleft{margin:0.5em 1em 0.5em 0}.mw-parser-output .portalright{clear:right;float:right;margin:0.5em 0 0.5em 1em}}</style><ul role="navigation" aria-label="Portals" class="noprint portalbox portalborder portalright"> <li class="portalbox-entry"><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/12px-WHO_Rod.svg.png" decoding="async" width="12" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/18px-WHO_Rod.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/24px-WHO_Rod.svg.png 2x" data-file-width="107" data-file-height="250" /><a href="/wiki/Portal:Medicine" title="Portal:Medicine">Medicine portal</a></li><li class="portalbox-entry"><a href="/wiki/File:Sida-aids.png" class="mw-file-description"><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Sida-aids.png/28px-Sida-aids.png" decoding="async" width="28" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Sida-aids.png/42px-Sida-aids.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Sida-aids.png/56px-Sida-aids.png 2x" data-file-width="290" data-file-height="290" /></a><a href="/wiki/Portal:Viruses" title="Portal:Viruses">Viruses portal</a></li></ul> <ul><li><a href="/wiki/Infectious_causes_of_cancer" title="Infectious causes of cancer">Infectious causes of cancer</a></li> <li><a href="/wiki/Oncovirus" title="Oncovirus">Oncovirus</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=22" title="Edit section: References">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-WHO2022-1">^ <a href="#cite_ref-WHO2022_1-0">a</a> <a href="#cite_ref-WHO2022_1-1">b</a> <a href="#cite_ref-WHO2022_1-2">c</a> <a href="#cite_ref-WHO2022_1-3">d</a> <a href="#cite_ref-WHO2022_1-4">e</a> <a href="#cite_ref-WHO2022_1-5">f</a> <a href="#cite_ref-WHO2022_1-6">g</a> <a href="#cite_ref-WHO2022_1-7">h</a> <a href="#cite_ref-WHO2022_1-8">i</a> <a href="#cite_ref-WHO2022_1-9">j</a> <a href="#cite_ref-WHO2022_1-10">k</a> <a href="#cite_ref-WHO2022_1-11">l</a> <a href="#cite_ref-WHO2022_1-12">m</a> <a href="#cite_ref-WHO2022_1-13">n</a> <a href="#cite_ref-WHO2022_1-14">o</a> <a href="#cite_ref-WHO2022_1-15">p</a> <a href="#cite_ref-WHO2022_1-16">q</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output 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.mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" 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Lancet. 1 (7649): 695–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0140-6736%2870%2990926-8">10.1016/S0140-6736(70)90926-8</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/4190997">4190997</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Virus-like+particles+in+serum+of+patients+with+Australia-antigen-associated+hepatitis&rft.volume=1&rft.issue=7649&rft.pages=%3Cspan+class%3D%22nowrap%22%3E695-%3C%2Fspan%3E8&rft.date=1970-04&rft_id=info%3Adoi%2F10.1016%2FS0140-6736%2870%2990926-8&rft_id=info%3Apmid%2F4190997&rft.aulast=Dane&rft.aufirst=DS&rft.au=Cameron%2C+CH&rft.au=Briggs%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHepatitis+B" class="Z3988"> </li> <li id="cite_note-hepborg-131"><a href="#cite_ref-hepborg_131-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.hepb.org/prevention-and-diagnosis/vaccination/history-of-hepatitis-b-vaccine/">"Hepatitis B Vaccine History"</a>. Hepatitis B Foundation. Retrieved 8 November 2020.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Hepatitis+B+Foundation&rft.atitle=Hepatitis+B+Vaccine+History&rft_id=https%3A%2F%2Fwww.hepb.org%2Fprevention-and-diagnosis%2Fvaccination%2Fhistory-of-hepatitis-b-vaccine%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHepatitis+B" class="Z3988"> </li> <li id="cite_note-132"><a href="#cite_ref-132">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGalibertMandartFitoussiTiollais1979" class="citation journal cs1">Galibert F, Mandart E, Fitoussi F, Tiollais P, Charnay P (October 1979). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F281646a0">"Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli"</a>. Nature. 281 (5733): 646–50. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1979Natur.281..646G">1979Natur.281..646G</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F281646a0">10.1038/281646a0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/399327">399327</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Nucleotide+sequence+of+the+hepatitis+B+virus+genome+%28subtype+ayw%29+cloned+in+E.+coli&rft.volume=281&rft.issue=5733&rft.pages=%3Cspan+class%3D%22nowrap%22%3E646-%3C%2Fspan%3E50&rft.date=1979-10&rft_id=info%3Apmid%2F399327&rft_id=info%3Adoi%2F10.1038%2F281646a0&rft_id=info%3Abibcode%2F1979Natur.281..646G&rft.aulast=Galibert&rft.aufirst=F&rft.au=Mandart%2C+E&rft.au=Fitoussi%2C+F&rft.au=Tiollais%2C+P&rft.au=Charnay%2C+P&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252F281646a0&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHepatitis+B" class="Z3988"> </li> <li id="cite_note-pmid6108398-133"><a href="#cite_ref-pmid6108398_133-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation journal cs1"><a rel="nofollow" class="external text" href="https://www.semanticscholar.org/paper/eb4305eaeff8d03293fcd4d0907b63d904a61f68">"Hepatitis B vaccine"</a>. Lancet. 2 (8206): 1229–1230. December 1980. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0140-6736%2880%2992484-8">10.1016/S0140-6736(80)92484-8</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/6108398">6108398</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:43614988">43614988</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Hepatitis+B+vaccine&rft.volume=2&rft.issue=8206&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1229-%3C%2Fspan%3E1230&rft.date=1980-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A43614988%23id-name%3DS2CID&rft_id=info%3Apmid%2F6108398&rft_id=info%3Adoi%2F10.1016%2FS0140-6736%2880%2992484-8&rft_id=https%3A%2F%2Fwww.semanticscholar.org%2Fpaper%2Feb4305eaeff8d03293fcd4d0907b63d904a61f68&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHepatitis+B" class="Z3988"> </li> <li id="cite_note-134"><a href="#cite_ref-134">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://apps.who.int/gb/ebwha/pdf_files/EB126/B126_R16-en.pdf">"Viral hepatitis"</a> (PDF). World Health Organization. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20110811014812/http://apps.who.int/gb/ebwha/pdf_files/EB126/B126_R16-en.pdf">Archived</a> (PDF) from the original on 11 August 2011.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Viral+hepatitis&rft.pub=World+Health+Organization&rft_id=http%3A%2F%2Fapps.who.int%2Fgb%2Febwha%2Fpdf_files%2FEB126%2FB126_R16-en.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHepatitis+B" class="Z3988"> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2>[<a href="/w/index.php?title=Hepatitis_B&action=edit&section=23" title="Edit section: External links">edit</a>]</div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid 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dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-label="Navbox32" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q6853" class="extiw" title="d:Q6853">D</a></div><div class="hlist" style="text-align:left;"><ul><li><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-10" title="ICD-10">10</a>: <a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/B16">B16</a>, <a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/B18.0">B18.0</a>–<a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/B18.1">B18.1</a></li><li><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/List_of_ICD-9_codes" title="List of ICD-9 codes">9-CM</a>: <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=070.2">070.2</a>–<a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=070.3">070.3</a></li><li><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/610424">610424</a></li><li><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D006509">D006509</a></li><li><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a>: <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb5765.htm">5765</a></li><li><a href="/wiki/SNOMED_CT" title="SNOMED CT">SNOMED CT</a>: <a rel="nofollow" class="external text" href="http://snomed.info/id/66071002">66071002</a></li></ul></div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">External resources</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist" style="text-align:left;"><ul><li><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a>: <a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/medlineplus/ency/article/000279.htm">000279</a></li><li><a href="/wiki/EMedicine" title="EMedicine">eMedicine</a>: <a rel="nofollow" class="external text" href="https://emedicine.medscape.com/med/992-overview">med/992</a> <a rel="nofollow" class="external text" href="https://www.emedicine.com/ped/topic978.htm#">ped/978</a></li><li><a href="/wiki/Patient_UK" title="Patient UK">Patient UK</a>: <a rel="nofollow" class="external text" href="https://patient.info/doctor/hepatitis-b-pro">Hepatitis B</a></li></ul></div></div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1235681985">.mw-parser-output .side-box{margin:4px 0;box-sizing:border-box;border:1px solid #aaa;font-size:88%;line-height:1.25em;background-color:var(--background-color-interactive-subtle,#f8f9fa);display:flow-root}.mw-parser-output .side-box-abovebelow,.mw-parser-output .side-box-text{padding:0.25em 0.9em}.mw-parser-output .side-box-image{padding:2px 0 2px 0.9em;text-align:center}.mw-parser-output .side-box-imageright{padding:2px 0.9em 2px 0;text-align:center}@media(min-width:500px){.mw-parser-output .side-box-flex{display:flex;align-items:center}.mw-parser-output .side-box-text{flex:1;min-width:0}}@media(min-width:720px){.mw-parser-output .side-box{width:238px}.mw-parser-output .side-box-right{clear:right;float:right;margin-left:1em}.mw-parser-output .side-box-left{margin-right:1em}}</style><style data-mw-deduplicate="TemplateStyles:r1237033735">@media print{body.ns-0 .mw-parser-output .sistersitebox{display:none!important}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}</style><div class="side-box side-box-right plainlinks sistersitebox"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style> <div class="side-box-flex"> <div class="side-box-image"><a href="/wiki/File:Commons-logo.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/30px-Commons-logo.svg.png" decoding="async" width="30" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/45px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/59px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></div> <div class="side-box-text plainlist">Wikimedia Commons has media related to <a href="https://commons.wikimedia.org/wiki/Category:Hepatitis_B" class="extiw" title="commons:Category:Hepatitis B">Hepatitis B</a>.</div></div> </div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><a rel="nofollow" class="external text" href="http://apps.who.int/iris/bitstream/10665/154590/1/9789241549059_eng.pdf?ua=1&ua=1">GUIDELINES FOR THE PREVENTION, CARE AND TREATMENT OF PERSONS WITH CHRONIC HEPATITIS B INFECTION</a> (PDF). World Health Organization. March 2015. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978924154905-9" title="Special:BookSources/978924154905-9"><bdi>978924154905-9</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=GUIDELINES+FOR+THE+PREVENTION%2C+CARE+AND+TREATMENT+OF+PERSONS+WITH+CHRONIC+HEPATITIS+B+INFECTION&rft.pub=World+Health+Organization&rft.date=2015-03&rft.isbn=978924154905-9&rft_id=http%3A%2F%2Fapps.who.int%2Firis%2Fbitstream%2F10665%2F154590%2F1%2F9789241549059_eng.pdf%3Fua%3D1%26ua%3D1&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHepatitis+B" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10407">"Hepatitis B virus"</a>. NCBI Taxonomy Browser. 10407.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NCBI+Taxonomy+Browser&rft.atitle=Hepatitis+B+virus&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2FTaxonomy%2FBrowser%2Fwwwtax.cgi%3Fmode%3DInfo%26id%3D10407&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHepatitis+B" class="Z3988"></li></ul> </div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"></div><div role="navigation" class="navbox" aria-labelledby="Sexually_transmitted_infections_(STI)135" style="padding:3px"><table class="nowraplinks 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template">e</abbr></a></li></ul></div><div id="Sexually_transmitted_infections_(STI)135" style="font-size:114%;margin:0 4em"><a href="/wiki/Sexually_transmitted_infection" title="Sexually transmitted infection">Sexually transmitted infections</a> (STI)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bacteria" title="Bacteria">Bacterial</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chancroid" title="Chancroid">Chancroid</a> (<a href="/wiki/Haemophilus_ducreyi" title="Haemophilus ducreyi">Haemophilus ducreyi</a>)</li> <li><a href="/wiki/Chlamydia_infection" class="mw-redirect" title="Chlamydia infection">Chlamydia</a>, <a href="/wiki/Lymphogranuloma_venereum" title="Lymphogranuloma venereum">lymphogranuloma venereum</a> (<a href="/wiki/Chlamydia_trachomatis" title="Chlamydia trachomatis">Chlamydia trachomatis</a>)</li> <li><a href="/wiki/Granuloma_inguinale" title="Granuloma inguinale">Donovanosis</a> (<a href="/wiki/Klebsiella_granulomatis" title="Klebsiella granulomatis">Klebsiella granulomatis</a>)</li> <li><a href="/wiki/Gonorrhea" title="Gonorrhea">Gonorrhea</a> (<a href="/wiki/Neisseria_gonorrhoeae" title="Neisseria gonorrhoeae">Neisseria gonorrhoeae</a>)</li> <li><a href="/wiki/Mycoplasma_hominis_infection" title="Mycoplasma hominis infection">Mycoplasma hominis infection</a> (<a href="/wiki/Mycoplasma_hominis" title="Mycoplasma hominis">Mycoplasma hominis</a>)</li> <li><a href="/wiki/Syphilis" title="Syphilis">Syphilis</a> (<a href="/wiki/Treponema_pallidum" title="Treponema pallidum">Treponema pallidum</a>)</li> <li><a href="/wiki/Ureaplasma_infection" class="mw-redirect" title="Ureaplasma infection">Ureaplasma infection</a> (<a href="/wiki/Ureaplasma_urealyticum" title="Ureaplasma urealyticum">Ureaplasma urealyticum</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protozoa" title="Protozoa">Protozoal</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Trichomoniasis" title="Trichomoniasis">Trichomoniasis</a> (<a href="/wiki/Trichomonas_vaginalis" title="Trichomonas vaginalis">Trichomonas vaginalis</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Parasitism" title="Parasitism">Parasitic</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Crab_louse" title="Crab louse">Crab louse</a></li> <li><a href="/wiki/Scabies" title="Scabies">Scabies</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Virus" title="Virus">Viral</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS" title="HIV/AIDS">AIDS</a> (<a href="/wiki/HIV" title="HIV">HIV-1/HIV-2</a>)</li> <li>Cancer <ul><li><a href="/wiki/Cervical_cancer" title="Cervical cancer">cervical</a></li> <li><a href="/wiki/Vulvar_cancer" title="Vulvar cancer">vulvar</a></li> <li><a href="/wiki/Penile_cancer" title="Penile cancer">penile</a></li> <li><a href="/wiki/Anal_cancer" title="Anal cancer">anal</a></li></ul></li> <li><a href="/wiki/Human_papillomavirus" class="mw-redirect" title="Human papillomavirus">Human papillomavirus (HPV)</a></li> <li><a href="/wiki/Genital_wart" title="Genital wart">Genital warts (condyloma)</a></li> <li><a class="mw-selflink selflink">Hepatitis B</a> (<a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">Hepatitis B virus</a>)</li> <li><a href="/wiki/Herpes" title="Herpes">Herpes simplex</a> <ul><li><a href="/wiki/Herpes_simplex_virus" title="Herpes simplex virus">HSV-1 & HSV-2</a></li></ul></li> <li><a href="/wiki/Molluscum_contagiosum" title="Molluscum contagiosum">Molluscum contagiosum</a> (<a href="/wiki/Molluscum_contagiosum_virus" title="Molluscum contagiosum virus">MCV</a>)</li> <li><a href="/wiki/Zika_fever" title="Zika fever">Zika fever</a> (<a href="/wiki/Zika_virus" title="Zika virus">Zika virus</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">General <a href="/wiki/Inflammation" title="Inflammation">inflammation</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt>female</dt> <dd><a href="/wiki/Cervicitis" title="Cervicitis">Cervicitis</a></dd> <dd><a href="/wiki/Pelvic_inflammatory_disease" title="Pelvic inflammatory disease">Pelvic inflammatory disease (PID)</a></dd></dl> <dl><dt>male</dt> <dd><a href="/wiki/Epididymitis" title="Epididymitis">Epididymitis</a></dd> <dd><a href="/wiki/Prostatitis" title="Prostatitis">Prostatitis</a></dd></dl> <dl><dt>either</dt> <dd><a href="/wiki/Proctitis" title="Proctitis">Proctitis</a></dd> <dd><a href="/wiki/Urethritis" title="Urethritis">Urethritis</a>/<a href="/wiki/Non-gonococcal_urethritis" title="Non-gonococcal urethritis">Non-gonococcal urethritis (NGU)</a></dd></dl> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Infectious_diseases_–_viral_systemic_diseases519" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Viral_systemic_diseases" title="Template:Viral systemic diseases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Viral_systemic_diseases" title="Template talk:Viral systemic diseases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Viral_systemic_diseases" title="Special:EditPage/Template:Viral systemic diseases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Infectious_diseases_–_viral_systemic_diseases519" style="font-size:114%;margin:0 4em"><a href="/wiki/Infection" title="Infection">Infectious diseases</a> – <a href="/wiki/Viral_disease" title="Viral disease">viral systemic diseases</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Oncovirus" title="Oncovirus">Oncovirus</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></dt> <dd><a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">HBV</a> <dl><dd><a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">Hepatocellular carcinoma</a></dd></dl></dd> <dd><a href="/wiki/Papillomaviridae" title="Papillomaviridae">HPV</a> <dl><dd><a href="/wiki/Cervical_cancer" title="Cervical cancer">Cervical cancer</a></dd> <dd><a href="/wiki/Anal_cancer" title="Anal cancer">Anal cancer</a></dd> <dd><a href="/wiki/Penile_cancer" title="Penile cancer">Penile cancer</a></dd> <dd><a href="/wiki/Vulvar_cancer" title="Vulvar cancer">Vulvar cancer</a></dd> <dd><a href="/wiki/Vaginal_cancer" title="Vaginal cancer">Vaginal cancer</a></dd> <dd><a href="/wiki/HPV-positive_oropharyngeal_cancer" title="HPV-positive oropharyngeal cancer">Oropharyngeal cancer</a></dd></dl></dd> <dd><a href="/wiki/Kaposi%27s_sarcoma-associated_herpesvirus" title="Kaposi's sarcoma-associated herpesvirus">KSHV</a> <dl><dd><a href="/wiki/Kaposi%27s_sarcoma" title="Kaposi's sarcoma">Kaposi's sarcoma</a></dd></dl></dd> <dd><a href="/wiki/Epstein%E2%80%93Barr_virus" title="Epstein–Barr virus">EBV</a> <dl><dd><a href="/wiki/Nasopharyngeal_carcinoma" title="Nasopharyngeal carcinoma">Nasopharyngeal carcinoma</a></dd> <dd><a href="/wiki/Burkitt%27s_lymphoma" class="mw-redirect" title="Burkitt's lymphoma">Burkitt's lymphoma</a></dd> <dd><a href="/wiki/Hodgkin_lymphoma" title="Hodgkin lymphoma">Hodgkin lymphoma</a></dd> <dd><a href="/wiki/Follicular_dendritic_cell_sarcoma" title="Follicular dendritic cell sarcoma">Follicular dendritic cell sarcoma</a></dd> <dd><a href="/wiki/Extranodal_NK/T-cell_lymphoma,_nasal_type" title="Extranodal NK/T-cell lymphoma, nasal type">Extranodal NK/T-cell lymphoma, nasal type</a></dd></dl></dd> <dd><a href="/wiki/Merkel_cell_polyomavirus" title="Merkel cell polyomavirus">MCPyV</a> <dl><dd><a href="/wiki/Merkel-cell_carcinoma" title="Merkel-cell carcinoma">Merkel-cell carcinoma</a></dd></dl></dd></dl> <dl><dt><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></dt> <dd><a href="/wiki/Hepatitis_C_virus" title="Hepatitis C virus">HCV</a> <dl><dd><a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">Hepatocellular carcinoma</a></dd> <dd><a href="/wiki/Splenic_marginal_zone_lymphoma" title="Splenic marginal zone lymphoma">Splenic marginal zone lymphoma</a></dd></dl></dd> <dd><a href="/wiki/Human_T-lymphotropic_virus_1" title="Human T-lymphotropic virus 1">HTLV-I</a> <dl><dd><a href="/wiki/Adult_T-cell_leukemia/lymphoma" title="Adult T-cell leukemia/lymphoma">Adult T-cell leukemia/lymphoma</a></dd></dl></dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immune_disorder" title="Immune disorder">Immune disorders</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV" title="HIV">HIV</a> <ul><li><a href="/wiki/HIV/AIDS" title="HIV/AIDS">AIDS</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Central_nervous_system_viral_disease" title="Central nervous system viral disease">Central nervous system</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Viral_encephalitis" title="Viral encephalitis">Encephalitis</a>/ <a href="/wiki/Viral_meningitis" title="Viral meningitis">meningitis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></dt> <dd><a href="/wiki/Human_polyomavirus_2" title="Human polyomavirus 2">Human polyomavirus 2</a> <dl><dd><a href="/wiki/Progressive_multifocal_leukoencephalopathy" title="Progressive multifocal leukoencephalopathy">Progressive multifocal leukoencephalopathy</a></dd></dl></dd></dl> <dl><dt><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></dt> <dd><a href="/wiki/Measles_morbillivirus" class="mw-redirect" title="Measles morbillivirus">MeV</a> <dl><dd><a href="/wiki/Subacute_sclerosing_panencephalitis" title="Subacute sclerosing panencephalitis">Subacute sclerosing panencephalitis</a></dd></dl></dd> <dd><a href="/wiki/Lymphocytic_choriomeningitis" title="Lymphocytic choriomeningitis">LCV</a> <dl><dd><a href="/wiki/Lymphocytic_choriomeningitis" title="Lymphocytic choriomeningitis">Lymphocytic choriomeningitis</a></dd></dl></dd> <dd><a href="/wiki/Arbovirus_encephalitis" class="mw-redirect" title="Arbovirus encephalitis">Arbovirus encephalitis</a></dd> <dd><a href="/wiki/Orthomyxoviridae" title="Orthomyxoviridae">Orthomyxoviridae</a> (probable) <dl><dd><a href="/wiki/Encephalitis_lethargica" title="Encephalitis lethargica">Encephalitis lethargica</a></dd></dl></dd> <dd><a href="/wiki/Rabies_virus" title="Rabies virus">RV</a> <dl><dd><a href="/wiki/Rabies" title="Rabies">Rabies</a></dd></dl></dd> <dd><a href="/wiki/Chandipura_vesiculovirus" title="Chandipura vesiculovirus">Chandipura vesiculovirus</a></dd> <dd><a href="/wiki/Herpesviral_meningitis" class="mw-redirect" title="Herpesviral meningitis">Herpesviral meningitis</a></dd> <dd><a href="/wiki/Ramsay_Hunt_syndrome_type_2" title="Ramsay Hunt syndrome type 2">Ramsay Hunt syndrome type 2</a></dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myelitis" title="Myelitis">Myelitis</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Poliovirus" title="Poliovirus">Poliovirus</a> <ul><li><a href="/wiki/Polio" title="Polio">Poliomyelitis</a></li> <li><a href="/wiki/Post-polio_syndrome" title="Post-polio syndrome">Post-polio syndrome</a></li></ul></li> <li><a href="/wiki/Human_T-lymphotropic_virus_1" title="Human T-lymphotropic virus 1">HTLV-I</a> <ul><li><a href="/wiki/Tropical_spastic_paraparesis" title="Tropical spastic paraparesis">Tropical spastic paraparesis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Eye_disease" title="Eye disease">Eye</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cytomegalovirus" title="Cytomegalovirus">Cytomegalovirus</a> <ul><li><a href="/wiki/Cytomegalovirus_retinitis" title="Cytomegalovirus retinitis">Cytomegalovirus retinitis</a></li></ul></li> <li><a href="/wiki/Herpes_simplex_virus" title="Herpes simplex virus">HSV</a> <ul><li><a href="/wiki/Herpes_simplex_keratitis" title="Herpes simplex keratitis">Herpes of the eye</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cardiovascular_disease" title="Cardiovascular disease">Cardiovascular</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Coxsackie_B_virus" title="Coxsackie B virus">CBV</a> <ul><li><a href="/wiki/Pericarditis" title="Pericarditis">Pericarditis</a></li> <li><a href="/wiki/Myocarditis" title="Myocarditis">Myocarditis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Respiratory_system" title="Respiratory system">Respiratory system</a>/ <a href="/wiki/Common_cold" title="Common cold">acute viral nasopharyngitis</a>/ <a href="/wiki/Viral_pneumonia" title="Viral pneumonia">viral pneumonia</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epstein%E2%80%93Barr_virus" title="Epstein–Barr virus">Epstein–Barr virus</a> <ul><li><a href="/wiki/Epstein%E2%80%93Barr_virus_infection" title="Epstein–Barr virus infection">EBV infection</a>/<a href="/wiki/Infectious_mononucleosis" title="Infectious mononucleosis">Infectious mononucleosis</a></li></ul></li> <li><a href="/wiki/Cytomegalovirus" title="Cytomegalovirus">Cytomegalovirus</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RNA_virus#Group_IV_–_positive-sense_ssRNA_viruses" title="RNA virus">IV</a>: <a href="/wiki/Human_coronavirus" class="mw-redirect" title="Human coronavirus">Human coronavirus</a> <a href="/wiki/Human_coronavirus_229E" title="Human coronavirus 229E">229E</a>/<a href="/wiki/Human_coronavirus_NL63" title="Human coronavirus NL63">NL63</a>/<a href="/wiki/Human_coronavirus_HKU1" title="Human coronavirus HKU1">HKU1</a>/<a href="/wiki/Human_coronavirus_OC43" title="Human coronavirus OC43">OC43</a> <ul><li><a href="/wiki/Common_cold" title="Common cold">Common cold</a></li></ul></li> <li><a href="/wiki/Middle_East_respiratory_syndrome%E2%80%93related_coronavirus" class="mw-redirect" title="Middle East respiratory syndrome–related coronavirus">MERS coronavirus</a> <ul><li><a href="/wiki/Middle_East_respiratory_syndrome" class="mw-redirect" title="Middle East respiratory syndrome">Middle East respiratory syndrome</a></li></ul></li> <li><a href="/wiki/Severe_acute_respiratory_syndrome_coronavirus" class="mw-redirect" title="Severe acute respiratory syndrome coronavirus">SARS coronavirus</a> <ul><li><a href="/wiki/Severe_acute_respiratory_syndrome" class="mw-redirect" title="Severe acute respiratory syndrome">Severe acute respiratory syndrome</a></li></ul></li> <li><a href="/wiki/SARS-CoV-2" title="SARS-CoV-2">SARS-CoV-2</a> <ul><li><a href="/wiki/COVID-19" title="COVID-19">COVID-19</a></li></ul></li></ul> <ul><li><a href="/wiki/RNA_virus#Group_V_–_negative-sense_ssRNA_viruses" title="RNA virus">V</a>, <a href="/wiki/Orthomyxoviridae" title="Orthomyxoviridae">Orthomyxoviridae</a>: <a href="/wiki/Influenza_A_virus" title="Influenza A virus">Influenza virus A</a>/<a href="/wiki/Influenza_B_virus" title="Influenza B virus">B</a>/<a href="/wiki/Influenza_C_virus" title="Influenza C virus">C</a>/<a href="/wiki/Influenza_D_virus" title="Influenza D virus">D</a> <ul><li><a href="/wiki/Influenza" title="Influenza">Influenza</a>/<a href="/wiki/Avian_influenza" title="Avian influenza">Avian influenza</a></li></ul></li></ul> <ul><li>V, <a href="/wiki/Paramyxoviridae" title="Paramyxoviridae">Paramyxoviridae</a>: <a href="/wiki/Human_parainfluenza_viruses" title="Human parainfluenza viruses">Human parainfluenza viruses</a> <ul><li><a href="/wiki/Human_parainfluenza_viruses" title="Human parainfluenza viruses">Parainfluenza</a></li></ul></li> <li><a href="/wiki/Human_orthopneumovirus" class="mw-redirect" title="Human orthopneumovirus">Human orthopneumovirus</a></li> <li><a href="/wiki/Human_metapneumovirus" title="Human metapneumovirus">hMPV</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a 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class="navbox-group" style="width:1%"><a href="/wiki/Gastroenteritis#Viral" title="Gastroenteritis">Gastroenteritis</a>/ <a href="/wiki/Gastroenteritis#Virus" title="Gastroenteritis">diarrhea</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></dt> <dd><a href="/wiki/Adenoviridae" title="Adenoviridae">Adenovirus</a> <dl><dd><a href="/wiki/Adenovirus_infection" title="Adenovirus infection">Adenovirus infection</a></dd></dl></dd></dl> <dl><dt><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></dt> <dd><a href="/wiki/Rotavirus" title="Rotavirus">Rotavirus</a> (<a href="/wiki/Rotaviral_gastroenteritis" class="mw-redirect" title="Rotaviral gastroenteritis">Gastroenteritis</a>)</dd> <dd><a href="/wiki/Norovirus" title="Norovirus">Norovirus</a></dd> <dd><a href="/wiki/Astrovirus" title="Astrovirus">Astrovirus</a></dd> <dd><a 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(<a href="/wiki/Hepatitis_D" title="Hepatitis D">D</a>)</dd> <dd><a href="/wiki/Orthohepevirus_A" title="Orthohepevirus A">HEV</a> (<a href="/wiki/Hepatitis_E" title="Hepatitis E">E</a>)</dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pancreatitis" title="Pancreatitis">Pancreatitis</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Coxsackie_B_virus" title="Coxsackie B virus">CBV</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Genitourinary_system" title="Genitourinary system">Urogenital</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BK_virus" title="BK virus">BK virus</a></li> <li><a href="/wiki/Mumps_virus" title="Mumps virus">MuV</a> 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