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href='https://www.longdom.org/peer-reviewed-journals/dna-1363.html'>DNA</a> synthesis. They affect <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/dna-1363.html'>DNA</a> synthesis by acting as a substitute to the actual metabolites that would be used in the normal metabolism (for example antifolates interfere with the use of folic acid). Many antimetabolites are used for therapeutic purposes. Sulfanilamides, for example, are antimetabolites that disrupt bacterial, but not human, metabolism and are used to eradicate bacterial infections in humans. Other examples include antagonists of purines (azathioprine, mercaptopurine, and thioguanine) and antagonists of pyrimidine (fluorouracil and floxuridine). Cytarabine, which also has antiviral properties, interferes with dihydrofolate reductase, which is necessary for the synthesis of tetrahydrofolate and subsequently for the synthesis of the folic acid needed for <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/dna-1363.html'>DNA</a> formation. Methotrexate, used most often in the treatment of acute leukemia, breast cancer, <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/lung-47780.html'>lung</a> cancer, and osteogenic <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/sarcoma-29576.html'>sarcoma</a> (osteosarcoma), has also been used in low doses for the treatment of rheumatoid arthritis.</p> <p><strong>Related <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/journals-8492.html'>journals</a> of  Antimetabolites</strong></p> <p>Cancer <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/medicine-3406.html'>Medicine</a> & Anti <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-532.html'>Cancer</a> Drugs, Journal of Leukemia, Chemotherapy, Cervical Cancer, Journal of <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-532.html'>Cancer</a> Diagnosis, Oncogenesis, Critical Reviews in Oncogenesis, <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-532.html'>Cancer</a> Letters, <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-532.html'>Cancer</a> Microenvironment, Journal of Experimental and Clinical <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-532.html'>Cancer</a> Research, Molecular Carcinogenesis, Prostate <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-532.html'>Cancer</a> and Prostatic Diseases, Breast <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-532.html'>Cancer</a> Research and Treatment.</p> <div class="row"> <div class="col">  </div> <div class="col">  </div> </div> </div> </div> </div> </section>  <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Content Links</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://www.longdom.org/online-tools.html" title="Click here">Tools</a> </li> <li><a class="" href="https://www.longdom.org/feedback.html" title="Click here">Feedback</a></li> <li><a class="" href="https://www.longdom.org/careers.html" title="Click here">Careers</a></li> <li><a class="" href="https://www.longdom.org/privacy-policy.html" title="Click here">Privacy Policy</a></li> <li><a class="" href="https://www.longdom.org/terms-conditions.html" title="Click here">Terms & Conditions</a></li> <li><a class="" href="https://www.longdom.org/authors-reviewers-editors.html" title="Click here">Authors, Reviewers & Editors</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contact Longdom</h4> <p>Longdom Group SA<br> Avenue Roger Vandendriessche,<br> 18, 1150 Brussels, Belgium<br> Phone: +442038085340 <br><strong>Email:</strong> <a href="mailto:info@longdom.org" class="white" title="Click here">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Connect</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Click here" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i> Facebook</a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Click here" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i> Linkedin</a> <a href="https://twitter.com/LongdomP" title="Click here" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i> Twitter</a> <a href="https://www.instagram.com/longdom_publisher/" title="Click here" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i> Instagram</a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>Copyright © 2024 <a href="https://www.longdom.org/" title="Click here" class="white">Longdom Publishing</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script defer src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script defer src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script defer src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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