CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '8e8f7693d9b144c7',cH: 'GsKSdNnGF9cs3Ex6pvQ423Wi8SMTeOssEtnJG3E5ZtU-1732682668-1.2.1.1-GISR2L3PTJenfWomOqEOhkCornxHwzsKKT7.mNYXUfAvqTBPSbtef_H0Y2NC8jn_',cUPMDTk: "\/doi\/10.1021\/jacs.7b10647?__cf_chl_tk=BWO7ZouJuVBSOTTaKRHI2Fjsb3HiaBm00DAZRuJ54gI-1732682668-1.0.1.1-lRBb8eXCvz8mbr4ltBcJ0A7z9RcNTHvyRmEORmnGtoo",cFPWv: 'b',cITimeS: '1732682668',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/jacs.7b10647?__cf_chl_f_tk=BWO7ZouJuVBSOTTaKRHI2Fjsb3HiaBm00DAZRuJ54gI-1732682668-1.0.1.1-lRBb8eXCvz8mbr4ltBcJ0A7z9RcNTHvyRmEORmnGtoo",md: "ir3Wi_vr5kO7Wjd7S8ZvXZwzDoM6Yq8bcJYcf1M7Dzo-1732682668-1.2.1.1-E2BNjGwjSjlIZwu2B_L5d7F6MDSUrNF1pZxZaclI7DSxi33qhFnHGug2y_5mvYAuCu_Xr8LYAeo1GyKeOJxJ9wepjliqoZwpMKIEcEek1HEalaDBTorI4c_ofnSIohlXFO0q9JcmPVKV9kWlHuylnJi_M1lH5_zwRUTe.j8c.LhkiETSmuO41cCCgvXbfg6pPdMdAXRNyDziudtNNYFCJsXw3oCrfWvLJGys.tD63XjETXPGhT_sKI2F_6Ky0bIlaT0Bbd8sf8NO3WOsnmJIbqMr_FxU6gldAx.33r0YGYZjtZ0xGNNhU1SZ35jQOPSfdBM3JmFghs0Qckx4hGQ9XxhvfB54y4WlahAL_kU85cUyYX2rBYJS3qmDx_JMAbu4cc3V5wtDgfGZZuMbCSZaS3bD0CDRxAKq958UOUYsGegUyD44qO9g3pKijwMWGYskZBOeSlY7ZG3xFYgsmFtyCw0cj9P0XjL6f8GUPf_dQSUoKGKL2eCx2cc0nC7QfZtqw.WQdTEI8lw3zr0Nx.i6XdMYklaKpItX4jjx_v.zb_.b28wSwq_82tbVr3Y971yHYApBQlfraQN8qCvkfCUUB1A_ZKPJJXhxspu6kPd3Qbm9mmBVI1urj_aRTsqqPOTQQlfOgllMxVJpqaP4M0xXP4z7lauokLSZlTFXIOqkYw5d0OeIfTowfOeSZV0e_RksVgRZib.rIcHiKNe7POccj0UhaNEVWeU8KynaAVsKnPOFETqaA3BEpy.q0aZib6Doh2h2nrJ.83BfUiH.Dnz6aL_UBckMJqrHe4AI_P0Ds3Nvj5hNHQZrfAhlJ3lkf3wgfpZW8_fcXJHRL6fkroN25t.aWQjSNSjTLRrzsuSDtKEcJeUI.SynACaYOeP5FOExXvRsAAoa1gtyQEYfNtGPwZFJraUAgunAgF4U5DyINVJvctxal2w7NBRA68faQv75gWVPELuhqoqpFTyXuTS7hNMXiPUcJJo9RIq2xlnShsx3.1kPUpt7Qy7cyXWUaxP0vS9rBTALX6MF6gxTu7kID3J6PkHQpDEfl36Nqdf5F1PAhhEm2.9vwIdo_.rKdl2aJmI8V8DJ82p_d4ZL8LdSpPHND2T6ahwjp2VbcjA41ZnCzybofSnvSE2MGX6_IJ3o1cDeno2AvzXBYDfRJH_kn0H8C0xAgN3Xb55NSERoEnTBzIgA3CpgXAmeuj_t8P0JE4o6HhnQiCR8WdCu4vpQN5HSLwojbzYIJJodL7P0CiWXNDRDH7YfJB6NlVOo4H3JL0Wmd3rrStvLdbZjbEIGEsOfE6CVgNGJ9T.eZP7732bD4Iklgwg1q4goMWBuTk9oc9eKulE8XTimrELm_YdSXQLB0NCGsVKj3QDiUB.mgJ_TwibxS7V0EDPjIvXYp_cxKTCSq5VKwb1wJtCuQo2wC8dRG6nDsnrSTHH11r6xp_SWspGWLR_eSfsgjh55eLyE4Yfccm7909u.mfAGhTcEM.2_GluSWtx3e59fPYCEDyo5aEgSHKAgXu_eXN368K5OnBhNOwMK4mC15LQv6Oncjg0WUh.R9TMUARlizbEHCeBp5umcpkqkmbTWHGOHyr3h3NlGjpGiaQD4pBNmL3KPxBIjiaq6nZtsjhZVilYsLpb0gjxviDfUEf2X3mwLTcm18t7vqJU1h0hmqjmiIKE2gpCvDrijbsAYu5ILmVMnLnKNw8knWgsCCmj8Hk77dualGQuV2Y7qVj9BelA48IdhjhxHxnFgR0XfEmUAGr8afiMP3ikqnlejXwTxaLOTP1rMcKM.j559sqQ9CV3YbOpY2QtZmZSYEPiczWw5JFKR5t.9ZrUKNw.gYcmjdlUHofCjjP3TsOAFA6l3zOrw4_CaxkXiBvYyH92NhRwd5YNm_dEYugH_5BqbTqchZ_IvYgwmQ2ldurKMrGTCSFP_1KEh51FfQ3AtZSCM7ZQlkHAyHsZ86fo7H5tr47ukHB9LdOUWw5PQJ1BEeLKFw.Wh3FjMFJ5iODveMb6NQgNmaT8M.qTlYCQH66f2x86PLP5mlAi8vHdBCznTY7JnCHhmnscZ8TCQdF.1TIUVO5IAhFBG2uFx_kh0XHRQafcpQC43cbJgTUdWv.pxZlupzLZ0RX7DNCsOMkuG8YQQo39XuV51oyhLv_Mf4KfLSJEAh3os8eetirwZ.OKJ4XJMmBqQnSrUOZS0fN_Asyg0QLDPScPqZEW1LhQs057DZQlDidq7BnWRFlS2Aa6.HbNOndr1TaOhr_q5jh1tcr7MlqaxITwvfx2fEcTgaj_okq_gZCiZ0UyBsdrD4lW4eD7so4aJv_e7zcAdmeT9unqCwsVB6DefY3hMMXBt2YH2dZ6yezrJcMvmriVurqqEuXSvpjekhLj4tJpaubyj3oj91wT4T4T1PtzxZHKvACoO2JgewYtCuxupk7pTgtrcEQD44qH0rRXXi98H2gffvN093RNEk1d3yNV1XoFl0Jm5Q2Kdb3BcH50zQy9FDy6Tal1JkA3UJwMvNU_HC8U_dLe0Z2f1rDmH97ZyDaaT8S8O54lbqlFyRTwNy5_jxe9Dlz8TlkIw56moaBfpbWHTy0DbjVEj1vM.FLNQlqy4H.VlOWnk3XjuVOzeQeFhX_xdGuyHXtKMk0w8iHgWs2YBZIRcgIW8FYOEXHnpnmnbu5ONNNPtzFZPOw8Hrq_yEGt231dY8M.Hl5RiZPtUTw0FPz.i_rJWlPnOslhQrwcFuQari9VNqsikOXAhdN4OCKq9PULTcw8ksLXp1reDnU22Gsd5IlrG_Nd6hsUwn9S82EPUJB5Diww7JGP2DqNnKSxqsXtflSoiob7CilOIPcFoWC3azaF1DfCs75TrsYixP4cVlfiFrksB1zU8uk5YdXm6rUyO1JU4TZPTIdhesFthXpIDXvsJQWzZ1kiJa2Vm.tBu.oOjLXxSXrFUwIBWnycbY69MNlqPvGgZAg",mdrd: "WjbuwJaz.X8FWC0Hf1V83O52Kw_vokabXAsjAtEewtA-1732682668-1.2.1.1-19KEykVLNcLEAjpmOB59uX3AgSYrpirlGU14M5qY7t9m5ojML5qXPOjvR9q9xibuDImMZBadtoZWAf7s5aSzdzR6_5FE5zLj0mW7dPTepxsUSdnuNAqAwoA8tY_Fut1Qkz75yZOsOEvDbAl79RQmZyMrGB9HN_L.uFSVWoRSV.BbRoXvOEljy59Km3KIO8Oy_JLXyp4S.03folI.w6HLC5BxFrDKKOJNqlR2bQGtuEC.U2kCrM4E1APSv8ijrcynZvfLoMyWsiKMPmn6R1B3jmnuAbjNynSj1sfnspLKS2l9ZEvnskhNpeq54WpGIkED2USnDLj2ioo3uHcJDwSa3jlIpKKYXiQy4ZkLq1RnmvJPdsRDIsMnw1hECJEqfFrFj6LmxbgEF4o2t0Nnpp0dwlJRGn6wxxjFRd8XGg59FzWEg981fU12sRvlpkDQDowu2FxLVoallJEhvgxcx5q0duJPg8kkWyl_mw4Y2milG_ijrh5VG4utxoQQsFfYAur9Vd1ytZOoYy3wsIe5FW0OMv_ceH9SS71zQBx2007Sbg8oRhLsRggSli_BSgPoXHKvIvd3DzjLzcUPxLxEfyRWTl4dNawqA4vdXvIfqtEMxRdngROMRJTxASHnX7mvPX9honGSCCrVfMya..1w6MQvXiQBePdsAOseno0RopNnVygGvIGhRZd9.o3dC0I08iJLJqG82ScF.LG_wJXBRhK9ko7.y3T1F8_rqYbQ6_ep1oipny1TyUt60vEQAkmwHXcp_LDZttlvx4TcjEyxuSZhjm7rrhXOPKjiy0U3bwgwOvSA4GQBlFRM4NEHUml_bzoZGtNxDcX88ELdLT8NBME.nOF2fXMPq8VDPnkRiORVMTkP4W2K.rhuzldknJXDo3WlzRi7O4abP9Qx8QM1v7epzDk5ZQGjTcS6i7mUiK7bWy2rwk8Zkp9jqPGorbCOXHTUpNAKSuUnQsJLcVbKE2U0lrrrW.doRsaDF7rjTB5MPigZFbfurkhIJtoY9xr3Rfaf605H30xmMfhcgjwaqcybcOBsX3CNVDwRxxJpkKFEHKsizfW3.ik29a13cVuAWzMQK8Ezwc_Z_G7kSfVnT_uO5z_KlvFT8c2QWOzqeExBqdWZVlGdVl4pCoe_GYH3B1kTFtDSLy.1P4mW7lWBR6qDlgN8k9gGzwEJ1Cr8Vy5N8TBZpeC2NCE3IfLzbU_jqNvsevuWXZOpUaFxbYacsVw3JIORFNVaM.qDuaENiElzi.mjkVHbvlTIpEbLUcwHrnUcAqVf.TLJdWekdgtl.R5yJQbM_FQ4AbcvepNc.DO11UMUKWUXPR1levsFoy4TqX7R996EY.ru2T6ipgHiH_Qfk9aU1y6PVz9auyaY72wTIzG1KimKxEAZ_8wKKi9uHq4JwiCwXLqMswMAYfpA81kjUsdWdqecsqMgXwqyc2Q.baXMS7MXs5b.OSJBmh0M4wIRpTmp0tY8X1jbri.Phd10TgW7vKAtesfuHMhF84TkIGU1QpyfI9f315SeqMLAFM5.PtqLB3ddFhK.pHu3mduD7OaBVneQ3n1QB7RaijS8U6rhSdxMc0AAK3JWT659qH4pcqWVrRevyVxdU_uDfBSdShnMTvuWf6Gq4HSx6jfYCUG1H9iZJobq5uyV2I8ikV17ZVP3nna7pgHNxINiuXZ867pOjhg4onp5VeXQoF8aCoqdOco.IYbvCycrgiGO56ReRGfGKhzutGifkSmc7exSqdMb_1.4a.L785Lba9l_FCvz232wIQ.TwOijiPKpp8HYk3EfK7TOOVRaP0TxQep8VV8YQ.PE33YkKyzymmkcjcOhN_K510AvfBV1AvJdlAu5l3ilNasDBuUkaLUcRZRpKbZiOqrR_t8mknLOCwqLwVWLpm0BYF4DSX5LTFysxtDK7_cCh5xM_qXqTN7s1ApcmJBDb1zPUenCMRFt4ob9hCQ"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8e8f7693d9b144c7';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/jacs.7b10647?__cf_chl_rt_tk=BWO7ZouJuVBSOTTaKRHI2Fjsb3HiaBm00DAZRuJ54gI-1732682668-1.0.1.1-lRBb8eXCvz8mbr4ltBcJ0A7z9RcNTHvyRmEORmnGtoo" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>