TY - JFULL AU - N. Tuncbag and T. Haliloglu and O. Keskin PY - 2008/9/ TI - Observation of the Correlations between Pair Wise Interaction and Functional Organization of the Proteins, in the Protein Interaction Network of Saccaromyces Cerevisiae T2 - International Journal of Chemical and Molecular Engineering SP - 198 EP - 204 VL - 2 SN - 1307-6892 UR - https://publications.waset.org/pdf/4812 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 20, 2008 N2 - Understanding the cell's large-scale organization is an interesting task in computational biology. Thus, protein-protein interactions can reveal important organization and function of the cell. Here, we investigated the correspondence between protein interactions and function for the yeast. We obtained the correlations among the set of proteins. Then these correlations are clustered using both the hierarchical and biclustering methods. The detailed analyses of proteins in each cluster were carried out by making use of their functional annotations. As a result, we found that some functional classes appear together in almost all biclusters. On the other hand, in hierarchical clustering, the dominancy of one functional class is observed. In brief, from interaction data to function, some correlated results are noticed about the relationship between interaction and function which might give clues about the organization of the proteins. ER -