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Pre-Conference Workshop Day - 4th Novel Conjugates Summit
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fl-node-content"> <div class="fl-separator"></div> </div> </div> </div> </div> </div> </div> </div> </div> </header> <div id="fl-main-content" class="fl-page-content" itemprop="mainContentOfPage" role="main"> <div class="fl-content-full container"> <div class="row"> <div class="fl-content col-md-12"> <article class="fl-post post-23941 page type-page status-publish hentry" id="fl-post-23941" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-23941 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="23941"><div class="fl-row fl-row-full-width fl-row-bg-photo fl-node-bolxha7yeq4k fl-row-default-height fl-row-align-center" data-node="bolxha7yeq4k"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-e72f8zrjm5oa" data-node="e72f8zrjm5oa"> <div class="fl-col fl-node-4iu57docgyea fl-col-bg-color" data-node="4iu57docgyea"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-be4cj3klhxno fl-animation fl-fade-in" data-node="be4cj3klhxno" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <h1 class="fl-heading"> <span class="fl-heading-text"><b>Pre-Conference Workshop Day Agenda</b></span> </h1> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-mf2y6s70a4qj fl-row-default-height fl-row-align-center" data-node="mf2y6s70a4qj"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-yk56hgmrf31b" data-node="yk56hgmrf31b"> <div class="fl-col fl-node-9nrh3ia7d5kx fl-col-bg-color fl-col-has-cols" data-node="9nrh3ia7d5kx"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-e4icdwjfrnhb" data-node="e4icdwjfrnhb"> <div class="fl-module-content fl-node-content"> <div class="content"> <h1 class="eehw-agenda-title"> Pre-Conference Workshop Day<br /> <span><p>Tuesday 25th March 2025</p> </span> </h1> <div class="inner-agenda" style="background: #fde0e9"> <h3> <span class="time"> 9:00 am </span> Workshop A </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> Unlocking Strategies for Target Selection in Novel Conjugated Drugs </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://novel-conjugates.com/speakers/#speaker23849" class="view-speaker" speaker-id="23849"><span>Vicky Appleman</span></a></em> Associate Director, Oncology Drug Discovery, Takeda Pharmaceutical Co. Ltd. </li> <li> <em><a href="https://novel-conjugates.com/speakers/#speaker23838" class="view-speaker" speaker-id="23838"><span>Oliver Schon</span></a></em> VP, Research & Development, BiVictriX Therapeutics Ltd </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>Selecting the right target is undeniably important for novel conjugate drugs as it plays into the efficacy, toxicity profile, and therapeutic window, ultimately determining whether this new modality is worth pursuing. Join this in-depth workshop to explore advanced strategies in target selection for the development of cutting-edge conjugated drugs, for novel targets as well as previously validated ones. Gain insights into identifying and validating optimal targets to improve efficacy, safety, and clinical outcomes. </p> <p></p> <p>Join this workshop to: </p> <p></p> <ul> <li>Explore novel target identification for bispecific ADCs to enhance therapeutic selectivity and reduce off-target toxicity whilst getting the desired level of immune engagement </li> <li>Balance sufficient tumor cell expression without overexpression that limits penetration into large or solid tumors </li> <li>Discover the wider target space for degrader-antibody conjugates and explore the rationale behind target selection for well-matched antibody and protein of interest targets </li> <li>Develop antibody degrader conjugates with innovative approaches to selecting degradation targets, ensuring efficient and selective protein degradation </li> <li>Consider novel targets for peptide drug conjugates for improved stability, potency, as well as internalization into cells and crossing the BBB </li> <li>Address challenges in target validation and determining the most suitable biomarkers for guiding conjugated drug development</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:00 pm </span> Networking Lunch Break </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #d5e0ec"> <h3> <span class="time"> 1:00 pm </span> Workshop B </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> Design Considerations for Optimizing Pharmacokinetic Profiles in Novel Conjugated Drugs </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://novel-conjugates.com/speakers/#speaker23851" class="view-speaker" speaker-id="23851"><span>Hadi Falahatpisheh</span></a></em> Vice President - Research & Development, ALX Oncology Inc. </li> <li> <em><a href="https://novel-conjugates.com/speakers/#speaker23852" class="view-speaker" speaker-id="23852"><span>J Cory Kalvass</span></a></em> Research Fellow, AbbVie </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>Achieving a desirable efficacy and toxicity profile can be crucial for dose optimization, costeffectiveness and can ultimately determine whether a novel conjugate drug is worth investing in. This workshop will delve into how novel formats鈥攕uch as peptide drug conjugates (PDCs) or bispecific ADCs, or novel payloads with different mechanism of actions, such as antibody degrader conjugates (AbDCs), or alternative linker or conjugation technology can improve the therapeutic outcomes of drug conjugates </p> <p></p> <p>Join this workshop to: </p> <p></p> <ul> <li>Review case studies of recent clinical translation in conjugated drugs, discussing how pharmacokinetic (PK), pharmacodynamic (PD) endpoints can determine the key drivers of the efficacy and safety profiles of drug conjugates. </li> <li>Discuss the role and contribution of different components of drug conjugate (formats, linker-payload, and conjugation types) in overall stability and PK/PD attributes and targeted delivery of drug conjugates.</li> <li>Analyze the PK/PD, safety and efficacy endpoints across approved and advanced drug conjugates to gage the efficiency of the current ADC design in expanding the therapeutic window. </li> <li>Determine how novel formats, linker and conjugation technology, novel payloads and Drugto-Antibody Ration (DAR) can improve the efficiency of targeted delivery of next generation drug conjugates</li> </ul> </div> <!-- /Agenda content --> </div> </div> </div> </div> <div class="fl-col-group fl-node-svtpboe065c7 fl-col-group-nested" data-node="svtpboe065c7"> <div class="fl-col fl-node-5n897kcxptoj fl-col-bg-color fl-col-small" data-node="5n897kcxptoj"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-button fl-node-nhg5v6tid3mw" data-node="nhg5v6tid3mw"> <div class="fl-module-content fl-node-content"> <div class="fl-button-wrap fl-button-width-full fl-button-center"> <a href="https://novel-conjugates.com/whats-on/full-event-guide/" target="_self" class="fl-button"> <span class="fl-button-text">2024 Event Guide</span> </a> </div> </div> </div> </div> </div> <div class="fl-col fl-node-wsrkpe3uvotl fl-col-bg-color fl-col-small" 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We deliver insight and connections to facilitate safe and effective drug development for more personalized and targeted patient populations.</p> </div> </div> </div> <div class="fl-module fl-module-heading fl-node-vs34j9chu87d" data-node="vs34j9chu87d"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">EXPLORE OUR PRODUCTS</span> </h2> </div> </div> <div class="fl-module fl-module-rich-text fl-node-4ztu3gv2xk7s" data-node="4ztu3gv2xk7s"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <table style="height: 48px;" width="203"> <tbody> <tr> <td style="width: 94.7px;"><a href="https://hansonwade.com/life-sciences-conferences/" target="_blank" rel="noopener">Conferences</a></td> <td style="width: 94.7px;"><a href="https://hansonwade.com/beacon-life-sciences-data/" target="_blank" rel="noopener">Beacon</a></td> </tr> <tr> <td style="width: 94.7px;"><a href="https://hansonwade.com/intelligence-life-sciences-consultancy/">Intelligence</a></td> <td style="width: 94.7px;"></td> </tr> </tbody> </table> </div> </div> </div> </div> </div> <div class="fl-col fl-node-bq13acsokh72 fl-col-bg-color fl-col-small fl-col-small-custom-width fl-col-has-cols" data-node="bq13acsokh72"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-qbgoljdrf490" data-node="qbgoljdrf490"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">SEARCH</span> </h2> </div> </div> <div class="fl-module fl-module-ee-search fl-node-qbrx5sptlchy" data-node="qbrx5sptlchy"> <div class="fl-module-content fl-node-content"> <!-- This module is to pull through the page title, the background is will be the colour they have assigned in the customiser --> <form role="search" method="get" id="searchform" class="searchform" action="https://novel-conjugates.com/"> <div> <label 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else{control.removeClass('fa-volume-up').addClass('fa-volume-off');e.data.button.find('.fa-times').show();if('function'===typeof player.unMute){player.mute();} else{player.setVolume(0);}}},_videoBgSourceError:function(e){var source=$(e.target),wrap=source.closest('.fl-bg-video'),vid=wrap.find('video'),fallback=wrap.data('fallback'),fallbackTag='';source.remove();if(vid.find('source').length){return;}else if(''!==fallback){fallbackTag=$('<div></div>');fallbackTag.addClass('fl-bg-video-fallback');fallbackTag.css('background-image','url('+fallback+')');wrap.append(fallbackTag);vid.remove();}},_resizeBgVideos:function(){$('.fl-bg-video').each(function(){FLBuilderLayout._resizeBgVideo.apply(this);if($(this).parent().find('img').length>0){$(this).parent().imagesLoaded($.proxy(FLBuilderLayout._resizeBgVideo,this));}});},_resizeBgVideo:function(){if(0===$(this).find('video').length&&0===$(this).find('iframe').length){return;} var wrap=$(this),wrapHeight=wrap.outerHeight(),wrapWidth=wrap.outerWidth(),vid=wrap.find('video'),vidHeight=wrap.data('height'),vidWidth=wrap.data('width'),newWidth=wrapWidth,newHeight=Math.round(vidHeight*wrapWidth/vidWidth),newLeft=0,newTop=0,iframe=wrap.find('iframe'),isRowFullHeight=$(this).closest('.fl-row-bg-video').hasClass('fl-row-full-height'),vidCSS={top:'50%',left:'50%',transform:'translate(-50%,-50%)',};if(vid.length){if(vidHeight===''||typeof vidHeight==='undefined'||vidWidth===''||typeof vidWidth==='undefined'){vid.css({'left':'0px','top':'0px','width':newWidth+'px'});vid.on('loadedmetadata',FLBuilderLayout._resizeOnLoadedMeta);return;} if(!isRowFullHeight){if(newHeight<wrapHeight){newHeight=wrapHeight;newLeft=-((newWidth-wrapWidth)/ 2);newWidth=vidHeight?Math.round(vidWidth*wrapHeight/vidHeight):newWidth;} else{newTop=-((newHeight-wrapHeight)/2);} vidCSS={left:newLeft+'px',top:newTop+'px',height:newHeight+'px',width:newWidth+'px',}} vid.css(vidCSS);} else if(iframe.length){if(typeof wrap.data('youtube')!=='undefined'){FLBuilderLayout._resizeYoutubeBgVideo.apply(this);}}},_resizeOnLoadedMeta:function(){var video=$(this),wrapHeight=video.parent().outerHeight(),wrapWidth=video.parent().outerWidth(),vidWidth=video[0].videoWidth,vidHeight=video[0].videoHeight,newHeight=Math.round(vidHeight*wrapWidth/vidWidth),newWidth=wrapWidth,newLeft=0,newTop=0;if(newHeight<wrapHeight){newHeight=wrapHeight;newWidth=Math.round(vidWidth*wrapHeight/vidHeight);newLeft=-((newWidth-wrapWidth)/2);} else{newTop=-((newHeight-wrapHeight)/2);} video.parent().data('width',vidWidth);video.parent().data('height',vidHeight);video.css({'left':newLeft+'px','top':newTop+'px','width':newWidth+'px','height':newHeight+'px'});},_resizeYoutubeBgVideo:function(){var wrap=$(this),wrapWidth=wrap.outerWidth(),wrapHeight=wrap.outerHeight(),player=wrap.data('YTPlayer'),video=player?player.getIframe():null,aspectRatioSetting='16:9',aspectRatioArray=aspectRatioSetting.split(':'),aspectRatio=aspectRatioArray[0]/ aspectRatioArray[1],ratioWidth=wrapWidth / aspectRatio,ratioHeight=wrapHeight*aspectRatio,isWidthFixed=wrapWidth / wrapHeight>aspectRatio,width=isWidthFixed?wrapWidth:ratioHeight,height=isWidthFixed?ratioWidth:wrapHeight;if(video){$(video).width(width).height(height);}},_initModuleAnimations:function(){if(typeof jQuery.fn.waypoint!=='undefined'){$('.fl-animation').each(function(){var node=$(this),nodeTop=node.offset().top,winHeight=$(window).height(),bodyHeight=$('body').height(),waypoint=FLBuilderLayoutConfig.waypoint,offset='80%';if(typeof waypoint.offset!==undefined){offset=FLBuilderLayoutConfig.waypoint.offset+'%';} if(bodyHeight-nodeTop<winHeight*0.2){offset='100%';} node.waypoint({offset:offset,handler:FLBuilderLayout._doModuleAnimation});});}},_doModuleAnimation:function(){var module='undefined'==typeof this.element?$(this):$(this.element),delay=parseFloat(module.data('animation-delay')),duration=parseFloat(module.data('animation-duration'));if(!isNaN(duration)){module.css('animation-duration',duration+'s');} if(!isNaN(delay)&&delay>0){setTimeout(function(){module.addClass('fl-animated');},delay*1000);}else{setTimeout(function(){module.addClass('fl-animated');},1);}},_initHash:function(){var hash=window.location.hash.replace('#','').split('/').shift(),element=null,tabs=null,responsiveLabel=null,tabIndex=null,label=null;if(''!==hash){try{element=$('#'+hash);if(element.length>0){if(element.hasClass('fl-accordion-item')){setTimeout(function(){element.find('.fl-accordion-button').trigger('click');},100);} 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element=$('#'+id);if(element.length>0){flNode=element.hasClass('fl-row')||element.hasClass('fl-col')||element.hasClass('fl-module');if(!element.hasClass('fl-no-scroll')&&(link.hasClass('fl-scroll-link')||flNode)){$(link).on('click',FLBuilderLayout._scrollToElementOnLinkClick);} if(element.hasClass('fl-accordion-item')){$(link).on('click',FLBuilderLayout._scrollToAccordionOnLinkClick);} if(element.hasClass('fl-tabs-panel')){$(link).on('click',FLBuilderLayout._scrollToTabOnLinkClick);}}} catch(e){}}}},_scrollToElementOnLinkClick:function(e,callback){var element=$('#'+$(this).attr('href').split('#').pop());FLBuilderLayout._scrollToElement(element,callback);e.preventDefault();},_scrollToElement:function(element,callback){var config=FLBuilderLayoutConfig.anchorLinkAnimations,dest=0,win=$(window),doc=$(document);if(element.length>0){if('fixed'===element.css('position')||'fixed'===element.parent().css('position')){dest=element.position().top;} else 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$(nestedCols).each(function(index,col){if($(col).width()<=0){$(col).css('width',FLBuilderLayoutConfig.emptyColWidth);}});},_adjustRowShapeLayerHeight:function(){var rowShapeLayers=$('.fl-builder-shape-layer');$(rowShapeLayers).each(function(index){var rowShapeLayer=$(this),shape=$(rowShapeLayer).find('svg'),height=shape.height(),excludeShapes='.fl-builder-shape-circle, .fl-builder-shape-dot-cluster, .fl-builder-shape-topography, .fl-builder-shape-rect';if(!rowShapeLayer.is(excludeShapes)){$(shape).css('height',Math.ceil(height));}});},_string_to_slug:function(str){str=str.replace(/^\s+|\s+$/g,'');if('undefined'==typeof window._fl_string_to_slug_regex){regex=new RegExp('[^a-zA-Z0-9\'":() !.,-_|]','g');}else{regex=new RegExp('[^'+window._fl_string_to_slug_regex+'\'":\(\) !.,-_|\\\p{Letter}]','ug');} str=str.replace(regex,'').replace(/\s+/g,' ');return str;},_reorderMenu:function(){if($('#wp-admin-bar-fl-builder-frontend-edit-link-default 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.fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-5ba1fe150af26 .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){FLBuilderMenu=function(settings){this.nodeId=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-menu';this.type=settings.type;this.mobileToggle=settings.mobile;this.mobileBelowRow=settings.mobileBelowRow;this.mobileFlyout=settings.mobileFlyout;this.breakPoints=settings.breakPoints;this.mobileBreakpoint=settings.mobileBreakpoint;this.currentBrowserWidth=$(window).width();this.postId=settings.postId;this.mobileStacked=settings.mobileStacked;this._initMenu();$(window).on('resize',$.proxy(function(e){var width=$(window).width();if(width!=this.currentBrowserWidth){this.currentBrowserWidth=width;this._initMenu();this._clickOrHover();} this._resizeFlyoutMenuPanel();},this));$(window).on('scroll',$.proxy(function(e){this._resizeFlyoutMenuPanel();},this));$('body').on('click',$.proxy(function(e){if('undefined'!==typeof FLBuilderConfig){return;} var activeMobileMenu=$(this.wrapperClass+' .fl-menu-mobile-toggle.fl-active');if(activeMobileMenu.length&&('expanded'!==this.mobileToggle)){$(activeMobileMenu).trigger('click');} $(this.wrapperClass).find('.fl-has-submenu').removeClass('focus');$(this.wrapperClass).find('.fl-has-submenu .sub-menu').removeClass('focus');},this));$(this.wrapperClass+' ul.menu > li:last-child').on('focusout',$.proxy(function(e){if($(this.wrapperClass).find('.fl-menu-mobile-toggle').hasClass('fl-active')&&('expanded'!==this.mobileToggle)){if(!$(e.relatedTarget).parent().hasClass('menu-item')){$(this.wrapperClass).find('.fl-menu-mobile-toggle').trigger('click');}}},this));};FLBuilderMenu.prototype={nodeClass:'',wrapperClass:'',type:'',breakPoints:{},$submenus:null,_isMobile:function(){return this.currentBrowserWidth<=this.breakPoints.small?true:false;},_isMedium:function(){return this.currentBrowserWidth<=this.breakPoints.medium?true:false;},_isLarge:function(){return this.currentBrowserWidth<=this.breakPoints.large?true:false;},_isMenuToggle:function(){if(('always'==this.mobileBreakpoint||(this._isMobile()&&'mobile'==this.mobileBreakpoint)||(this._isMedium()&&'medium-mobile'==this.mobileBreakpoint)||(this._isLarge()&&'large-mobile'==this.mobileBreakpoint))&&($(this.wrapperClass).find('.fl-menu-mobile-toggle').is(':visible')||'expanded'==this.mobileToggle)){return true;} return false;},_initMenu:function(){this._setupSubmenu();this._menuOnFocus();this._menuOnEscape();this._submenuOnClick();if($(this.nodeClass).length&&this.type=='horizontal'){this._initMegaMenus();} if(this._isMenuToggle()||this.type=='accordion'){$(this.wrapperClass).off('mouseenter mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > 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activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> 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if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cb735f42d5d2',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;;jQuery(function($){$(function(){$('.fl-node-fr2b3cz60env .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){$(function(){new FLBuilderMenu({id:'e813jahlbt0f',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} 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