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bricks-menu-item"><a href="https://shanghaiarchivesofpsychiatry.org/currentissue.aspx">Current Issue</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page current-menu-item page_item page-item-205 current_page_item menu-item-216 bricks-menu-item"><a href="https://shanghaiarchivesofpsychiatry.org/inpress.aspx" aria-current="page">In Press</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-577 bricks-menu-item"><a href="https://shanghaiarchivesofpsychiatry.org/pastissues.aspx">Past Issues</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-217 bricks-menu-item"><a href="https://shanghaiarchivesofpsychiatry.org/aboutus.aspx">About Us</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-218 bricks-menu-item"><a href="https://shanghaiarchivesofpsychiatry.org/contribute.aspx">Manuscript Submission</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1284 bricks-menu-item"><a href="https://shanghaiarchivesofpsychiatry.org/midlife-crisis-and-its-impacts/">interviews</a></li> </ul></nav><div class="bricks-mobile-menu-overlay"></div></div></div></div></section></header><main id="brx-content"><section id="brxe-idlhfs" class="brxe-section bricks-lazy-hidden"><div id="brxe-mejsut" class="brxe-container bricks-lazy-hidden"><div id="brxe-xxwsvo" class="brxe-post-content"><p><span style="color: #339966;">Case report</span></p> <p><strong><span id="content_dlCategory_dlArticle_0_lblSubject_0" class="subject">Neuropsychiatric Symptoms Induced by Large Doses of Nitrous Oxide Inhalation: A Case Report</span></strong></p> <p><span id="content_dlCategory_dlArticle_0_lblAuthor_0" class="author">Tianzhen CHEN, Na ZHONG, Haifeng JIANG, Min ZHAO, Zhikang CHEN, Haiming SUN</span><span id="content_dlCategory_dlArticle_0_lblSummary_0" class="summary">Summary: Nitrous Oxide, which is also called laughing gas, now ranks as the 7th most popular drug in the world. Nitrous oxide mainly disturbs B12 metabolism and damages nerves, followed by apparent neuropsychiatric symptoms. It鈥檚 beneficial to the prognosis of patients if we identify and treat their symptoms early. This case report describes a 19-year-old male who presented with auditory hallucination,persecutory delusions and unstable emotions after abuse of nitrous oxide over the course of half a year.Moreover, neurological signs such as weakness and hyperesthesia also appeared. After supplementation of vitamin B12, the neuropsychiatric symptoms improved, while the lower extremities achieved partial recovery. Therapeutically, we should pay attention to nerve repair, motivation enhancement and reinforce interventions that prevent relapse. Key words: nitrous oxide; vitamin B12; neurologic impairment; mental disorders</span></p> <hr /> <p> </p> </div></div></section></main><footer id="brx-footer"><section id="brxe-meysax" class="brxe-section bricks-lazy-hidden"><div id="brxe-nvsigz" class="brxe-container bricks-lazy-hidden"><div id="brxe-klynmt" class="brxe-divider horizontal"><div class="line"></div></div></div><div id="brxe-nsmlzw" class="brxe-container bricks-lazy-hidden"><div id="brxe-dlzodb" class="brxe-block bricks-lazy-hidden"><div id="brxe-djhicc" class="brxe-text footer-text"><table> <tbody> <tr> <td class="tableheader"><span id="lblSubscribe">Subscribe</span></td> <td class="tableheader"><span id="lblSubmissions">Submissions</span></td> <td>聽</td> </tr> <tr> <td class="tables"><a id="lnkSubscribeElectronicVersion" class="tables" href="https://shanghaiarchivesofpsychiatry.org/subscribe.aspx">Electronic Version</a></td> <td><a id="lnkSubmitArticle" class="tables" 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