Synthesis, Characterization, Theoretical Crystal Structures and Antitubercular Activity Study of (E)-N'-(2,4-Dihydroxybenzylidene) Nicotinohydrazide and Some of Its Metal Complexes

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Title, Abstract, Keywords" value=""> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 88663</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Synthesis, Characterization, Theoretical Crystal Structures and Antitubercular Activity Study of (E)-N'-(2,4-Dihydroxybenzylidene) Nicotinohydrazide and Some of Its Metal Complexes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ogunniran%20Kehinde%20Olurotimi">Ogunniran Kehinde Olurotimi</a>, <a href="https://publications.waset.org/abstracts/search?q=Adekoya%20Joseph"> Adekoya Joseph</a>, <a href="https://publications.waset.org/abstracts/search?q=Ehi-Eromosele%20Cyril"> Ehi-Eromosele Cyril</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehdi%20Shihab"> Mehdi Shihab</a>, <a href="https://publications.waset.org/abstracts/search?q=Mesubi%20Adediran"> Mesubi Adediran</a>, <a href="https://publications.waset.org/abstracts/search?q=Tadigoppula%20Narender"> Tadigoppula Narender</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nicotinic acid hydrazide and 2,4-dihydoxylbenzaldehyde were condensed at 20掳C to form an acylhydrazone (H3L) with ONO coordination pattern. The structure of the acylhydrazone was elucidated by using CHN analyzer, ESI mass spectrometry, IR, 1H NMR, 13C NMR and 2D NMR such as COSY and HSQC. Thereafter, five novel metal complexes [Mn(II), Fe(II), Pt(II) Zn(II) and Pd(II)] of the hydrazone ligand were synthesized and their structural characterization were achieved by several physicochemical methods, namely elemental analysis, electronic spectra, infrared, EPR, molar conductivity and powder X-ray diffraction studies. Structural geometries of some of the compounds were supported by using Hyper Chem-8 program for the molecular mechanics and semi-empirical calculations. The stability energy (E) and electron potentials (eV) for the frontier molecules were calculated by using PM3 method. An octahedral geometry was suggested for both Pd(II) and Zn(II) complexes while both Mn(II) and Fe(II) complexes conformed with tetrahedral pyramidal. However, Pt(II) complex agreed with tetrahedral geometry. In vitro antitubercular activity study of the ligand and the metal complexes were evaluated against Mycobacterium tuberculosis, H37Rv, by using micro-diluted method. The results obtained revealed that (PtL1) (MIC = 0.56 碌g/mL), (ZnL1) (MIC = 0.61 碌g/mL), (MnL1) (MIC = 0.71 碌g/mL) and (FeL1) (MIC = 0.82 碌g/mL), exhibited a significant activity when compared with first line drugs such as isoniazid (INH) (MIC = 0.9 碌g/mL). H3L1 exhibited lesser antitubercular activity with MIC value of 1.02 碌g/mL. However, the metal complexes displayed higher cytoxicity but were found to be non-significant different (P 藗 0.05) to isoniazid drug. <iframe src="https://publications.waset.org/abstracts/45608.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrazones" title="hydrazones">hydrazones</a>, <a href="https://publications.waset.org/abstracts/search?q=electron%20spin%20resonance" title=" electron spin resonance"> electron spin resonance</a>, <a href="https://publications.waset.org/abstracts/search?q=thermogravimetric" title=" thermogravimetric"> thermogravimetric</a>, <a href="https://publications.waset.org/abstracts/search?q=powder%20X-ray%20diffraction" title=" powder X-ray diffraction"> powder X-ray diffraction</a>, <a href="https://publications.waset.org/abstracts/search?q=antitubercular%20agents" title=" antitubercular agents"> antitubercular agents</a> </p> <a href="https://publications.waset.org/abstracts/45608/synthesis-characterization-theoretical-crystal-structures-and-antitubercular-activity-study-of-e-n-24-dihydroxybenzylidene-nicotinohydrazide-and-some-of-its-metal-complexes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45608.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">274</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" 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Synthesis, Characterization, Theoretical Crystal Structures and Antitubercular Activity Study of (E)-N'-(2,4-Dihydroxybenzylidene) Nicotinohydrazide and Some of Its Metal Complexes