Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1 - CityU Scholars

<!doctype html><html lang="en"><head> <meta charset="utf-8" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <title>Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1 - CityU Scholars | A Research Hub of Excellence</title> <meta property="og:image" content="/resources/style/gfx/logo_top.png" /> <meta property="og:url" content="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).html" /> <link rel="image_src" type="image/png" href="/resources/style/gfx/logo_top.png" /> <link rel="icon" href="/resources/style/gfx/favicon.ico" type="image/x-icon" /> <link href="https://fonts.googleapis.com/css?family=Open+Sans:400,300,700,600" rel="stylesheet" type="text/css" /><link type="text/css" rel="stylesheet" href="/resources/style/fonts/icons/css/fontello.css?stamp=1731905518316" /><link type="text/css" rel="stylesheet" href="/resources/style/js/slick/slick.css?stamp=1731905518316" /><link type="text/css" rel="stylesheet" href="/resources/style/js/slick/slick-theme.css?stamp=1731905518316" /><link type="text/css" rel="stylesheet" href="/resources/style/css/main.css?stamp=1731905518316" /> <link type="text/css" rel="stylesheet" href="https://www.cityu.edu.hk/scholars/portal/css/main_cu.css" /><script type="text/javascript" src="/dwr/engine.js?stamp=1731905518316"></script><script type="text/javascript" src="/dwr/interface/PureFacade.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/lib/prototype.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/atira.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/atira_chart.js?stamp=1731905518316"></script><script type="text/javascript" src="/dwr/interface/GraphFacade.js?stamp=1731905518316"></script> <script type="text/javascript">(function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){(i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o),m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m)})(window,document,'script','//www.google-analytics.com/analytics.js','ga');ga('create', 'UA-11187669-7', { 'cookieDomain': document.location.hostname });ga('set', 'anonymizeIp', true);ga('send', 'pageview');</script> <meta name="citation_title" content="Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1" /><meta name="citation_author" content="Yan Li" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Dongmei Zhou" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Yinghui Ren" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Zimu Zhang" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Xiangdong Guo" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="MingKun Ma" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author_institution" content="Tianjin University of Traditional Chinese Medicine" /><meta name="citation_author" content="Zhenyi Xue" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Jienv Lv" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author_institution" content="Hexi Women & Children Healthcare and Family Planning Service Center" /><meta name="citation_author" content="Hongkun Liu" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Qing Xi" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Long Jia" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Lijuan Zhang" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Ying Liu" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Qi Zhang" /><meta name="citation_author_institution" content="Nankai Hospital" /><meta name="citation_author" content="Jun Yan" /><meta name="citation_author_institution" content="Tianjin Institute of Animal Husbandry and Veterinary" /><meta name="citation_author" content="Yurong Da" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Fei Gao" /><meta name="citation_author_institution" content="CAS - Institute of Zoology" /><meta name="citation_author" content="Jianbo Yue" /><meta name="citation_author_institution" content="Department of Biomedical Sciences" /><meta name="citation_author" content="Zhi Yao" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author" content="Rongxin Zhang" /><meta name="citation_author_institution" content="Tianjin Medical University" /><meta name="citation_author_institution" content="Guangdong College of Pharmacy" /><meta name="citation_publication_date" content="2019" /><meta name="citation_online_date" content="2021/06/03" /><meta name="citation_pdf_url" content="https://scholars.cityu.edu.hk/files/33120962/101.pdf" /><meta name="citation_online_date" content="2019/07/10" /><meta name="citation_doi" content="10.1080/15548627.2018.1522467" /><meta name="citation_language" content="English" /><meta name="citation_keywords" content="ATG16L1; autophagy; CNS inflammation; experimental autoimmune encephalomyelitis; microglia; Mir223" /><meta name="citation_pmid" content="30208760" /><meta name="citation_journal_title" content="Autophagy" /><meta name="citation_issn" content="1554-8627" /><meta name="citation_publisher" content="Taylor & Francis Inc." /><meta name="citation_volume" content="15" /><meta name="citation_issue" content="3" /><meta name="citation_pages" content="478–492" /> <noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-PZF4343" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-PZF4343');</script> <script type="text/javascript" src="/resources/style/js/jquery-3.1.1.min.js?stamp=1731905518316"></script> <script type="text/javascript">jQuery.noConflict();</script><script type="text/javascript" src="/resources/style/js/jquery.overflow-navigation.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/slick/slick.min.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/main.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/atira_flash.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/core/style/js/portal.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/lib/swfobject.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/components/web_graph.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/components/web_diagram.js?stamp=1731905518316"></script><link type="text/css" rel="stylesheet" href="/resources/style/css/components/web_diagram.css?stamp=1731905518316" /><script type="text/javascript" src="/resources/style/lib/d3/d3.v3.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/core/style/js/components/portal_graphviewer.js?stamp=1731905518316"></script><link type="text/css" rel="stylesheet" href="/resources/core/style/css/components/portal_graphviewer.css?stamp=1731905518316" /></head><body class="publications en_GB en ie ie7"> <div class="header"> <script async src=https://www.googletagmanager.com/gtag/js?id=G-ETKF41RWWH></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-ETKF41RWWH'); </script> <div class="top"> <div class="wrapper">  <a href="https://libguides.library.cityu.edu.hk/cityuscholars" target="_blank" class="researcher_login"><span>Researcher login</span></a> <div id="cityu-header-local"> <div id="cityu-desktop-cityulogo"> <a href="https://www.cityu.edu.hk"><img src="https://template.cityu.edu.hk/template/v2/logo/CityU/CityU_Vertical_Logo_CMYK.svg" alt="City University of Hong Kong"></img></a> </div> <div id="cityu-mobile-cityulogo"> <a href="https://www.cityu.edu.hk"> <img src="https://template.cityu.edu.hk/template/v2/logo/CityU/CityU_Vertical_Logo_CMYK.svg" alt="City University of Hong Kong"></img> </a> </div> <div id="cityu-mobile-cityulogo-xs"> <a href="https://www.cityu.edu.hk"> <img src="https://template.cityu.edu.hk/template/v2/logo/CityU/CityU_Vertical_Logo_CMYK.svg" alt="City University of Hong Kong"></img> </a> </div> <div id="cityu-header-deptnames"> <div class="cityu-wrapper"> <div id="cityu-header-deptname"> <a href="/">CityU Scholars</a> </div> <div id="cityu-header-parentname" class="red right"> A Research Hub of Excellence </div> </div> </div> </div> </div>  </div> <div class="menuwrapper"> <div class="wrapper"> <span class="burger"> <span class="burger-bars"></span> </span> <ul class="menu"> <li><a class="portal_link" href="/en/"><span> Home </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/persons/search.html?affiliationStatus=current&employmentStatus=staff"><span> Researchers </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/organisations/search.html"><span> Research Units </span></a> </li> <li class="selected"><a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/search.html"><span> Research Output </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/projects/search.html"><span> Projects </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/activities/search.html"><span> Activities </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/prizes/search.html"><span> Prizes/Honours </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/theses/search.html"><span> Student Theses </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/datasets/search.html"><span> Datasets </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/impact/search.html"><span> Impact </span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/clippings/search.html"><span> Press/Media </span></a> </li> </ul> </div> </div> </div> <div class="front-seacrh"> </div> <div class="main-content wrapper false "> <div class="col-1-1"><div class="rendering rendering_researchoutput rendering_researchoutput_compact rendering_researchoutput rendering_compact rendering_researchoutput_compact"><div class="rendering rendering_researchoutput rendering_researchoutput_compact rendering_researchoutput rendering_compact rendering_researchoutput_compact"><h1 class="title"><i>Mir223 </i>restrains autophagy and promotes CNS inflammation by targeting ATG16L1</h1></div><p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Journal Publications and Reviews<span class="type_parent_sep"> › </span></span><span class="type_classification">RGC 21 - Publication in refereed journal</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> <div class="tabs-container"> <ul class="clear"> <li class="selected"><a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).html"><span>Overview</span></a> </li> </ul> </div> <div class="pub-full"> <div class="pub-top"> <div class="view-box scopus"> <span class="number">113</span> <span>Scopus Citations</span> </div> <div class="view-box viewall-scopus"> <a target="_blank" class="view_all_scopus_button" href="https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85053677482&origin=recordpage"> Scopus Metrics </a> </div> <div class="view-box almetric"> <script type="text/javascript" src="//d1bxh8uas1mnw7.cloudfront.net/assets/embed.js"></script> <div class="altmetric-embed pure_altmetric_component" data-badge-type="2" data-badge-popover="left" data-hide-no-mentions="true" data-link-target="true" data-doi="10.1080/15548627.2018.1522467"></div> </div> <div class="graph_viewer"> <div class="graph"><a class="portal_graphviewer_button" href="javascript:void(0);" id="j_id-222676425_40f6ca2e"><span>View graph of relations</span></a> <script type="text/javascript"></script> <i class="icon-network"></i> </div> </div> <div class="addthis"> <div class="addthis_sharing_toolbox"></div> </div> </div> <div class="view-box"> <h2 class="subheader">Author(s)</h2><div class="rendering rendering_researchoutput rendering_researchoutput_associatesauthorsclassifiedsummarizedlistportal rendering_contributiontojournal rendering_associatesauthorsclassifiedsummarizedlistportal rendering_contributiontojournal_associatesauthorsclassifiedsummarizedlistportal"><ul class="relations persons"><li class="external">Yan Li</li><li class="external">Dongmei Zhou</li><li class="external">Yinghui Ren</li><li class="external">Zimu Zhang</li><li class="external">Xiangdong Guo</li><li><a onclick="$(this).up('ul').next('ul').toggleClassName('common_hidden');return false;" href="#" class="all link"><span>And 15 others</span></a></li></ul><ul class="relations persons common_hidden associates_authors_full_list"><li class="external">MingKun Ma</li><li class="external">Zhenyi Xue</li><li class="external">Jienv Lv</li><li class="external">Hongkun Liu</li><li class="external">Qing Xi</li><li class="external">Long Jia</li><li class="external">Lijuan Zhang</li><li class="external">Ying Liu</li><li class="external">Qi Zhang</li><li class="external">Jun Yan</li><li class="external">Yurong Da</li><li class="external">Fei Gao</li><li>Jianbo Yue</li><li class="external">Zhi Yao</li><li class="external">Rongxin Zhang</li></ul></div> </div> <div class="view-box"> <h2 class="subheader">Related Research Unit(s)</h2><div class="rendering rendering_researchoutput rendering_researchoutput_associatesorganisationsportal rendering_contributiontojournal rendering_associatesorganisationsportal rendering_contributiontojournal_associatesorganisationsportal"><ul class="relations organisations"><li class="a"><a rel="Organisation" href="https://scholars.cityu.edu.hk/en/organisations/department-of-biomedical-sciences(7f082170-95c7-47b9-b02b-8eaecd285c60).html" class="link"><span>Department of Biomedical Sciences</span></a></li></ul></div> </div> <div class="view-box"> <h2 class="subheader">Detail(s)</h2><div class="rendering rendering_researchoutput rendering_researchoutput_detailsportal rendering_contributiontojournal rendering_detailsportal rendering_contributiontojournal_detailsportal"><div class="article"><table class="properties"><tbody><tr class="language"><th scope="row">Original language</th><td>English</td></tr><tr><th scope="row">Pages (from-to)</th><td>478–492</td></tr><tr><th scope="row">Journal / Publication</th><td><a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/autophagy(95977567-508e-4b30-9e3b-3027cb835dc3)/publications.html" class="link"><span>Autophagy</span></a></td></tr><tr><th scope="row">Volume</th><td>15</td></tr><tr><th scope="row">Issue number</th><td>3</td></tr><tr><th scope="row">Online published</th><td><span class="date">13 Sept 2018</span></td></tr><tr class="status"><th scope="row">Publication status</th><td><span class="prefix">Published - </span><span class="date">2019</span></td></tr></tbody></table></div></div> </div> <div class="view-box"> <h2 class="subheader">Link(s)</h2> <table class="properties pub-links"> <tr> <th>DOI</th> <td><div class="rendering rendering_researchoutput rendering_researchoutput_versioneddoiextensionportal rendering_contributiontojournal rendering_versioneddoiextensionportal rendering_contributiontojournal_versioneddoiextensionportal"><h2 class="subheader">DOI</h3><ul class="relations links digital_object_identifiers"><li class="embargo_date_ended available open "><a onclick="window.open(this.href, '_blank','noopener,noreferrer'); return false;" href="https://doi.org/10.1080/15548627.2018.1522467" class="link"><span>https://doi.org/10.1080/15548627.2018.1522467</span></a> <span class="common_icon_16" style="background-image: url('/resources/style/icons/type/openaccess16.png');"></span><p class="dimmed">Final Published version</p></li></ul></div> </td> </tr> <tr> <th></th> <td> <span class="sfx-button" title="Check@CityULib"> <a href="https://julac.hosted.exlibrisgroup.com/primo-explore/openurl?ctx_ver=Z39.88-2004&ctx_tim=2024-11-23T20%3A51%3A52HKT&ctx_enc=info%3Aofi%2FencUTF-8&url_ver=Z39.88-2004&url_ctx_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Actx&rft.genre=article&rft_val_fmt=info%3Aofi%2Fkev%3Afmt%3Ajournal&rfr_id=info%3Asid%2F%3Apure&rft.atitle=%3Ci%3EMir223%20%3C%2Fi%3Erestrains%20autophagy%20and%20promotes%20CNS%20inflammation%20by%20targeting%20ATG16L1&rft_id=info%3Adoi%2F10.1080%2F15548627.2018.1522467&rft.aulast=Li&rft.aufirst=Yan&rft.auinit=Y&rft.date=2019&rft.volume=15&rft.issue=3&rft.issn=1554-8627&rft.jtitle=Autophagy&rft.pages=478%E2%80%93492&institution=CUH_ALMA&vid=CUH" target="_blank"> Check@CityULib </a> </span> </td> </tr> <tr> <th>Attachment(s)</th> <td><div class="rendering rendering_researchoutput rendering_researchoutput_versioneddocumentextensionportal rendering_contributiontojournal rendering_versioneddocumentextensionportal rendering_contributiontojournal_versioneddocumentextensionportal"><div class="subheader documents">Documents</div><ul class="relations documents"><li class="available"><a onclick="if (this.href) {window.open(this.href)}; return false;" href="https://scholars.cityu.edu.hk/files/33120962/101.pdf" class="link title"><span>26134367.pdf</span></a> <span class="common_icon_16" style="background-image: url('/resources/style/icons/type/openaccess16.png');"></span><p class="dimmed">Final Published version, 3.42 MB<span class="mimetype">, PDF</span></p></li></ul></div><div class="rendering rendering_keywordable rendering_keywordgroupcopyright rendering_keywordable_keywordgroupcopyright"><div class="publishercopyright"><span class="copy-header">Publisher's Copyright Statement</span><ul class="relations keywords"><li>This full text is made available under CC-BY-NC-ND 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/</li></ul></div></div> </td> </tr> <tr> <th>Link to Scopus</th> <td><a target="_blank" class="scopus-link-pub" href="https://www.scopus.com/record/display.uri?eid=2-s2.0-85053677482&origin=recordpage"> https://www.scopus.com/record/display.uri?eid=2-s2.0-85053677482&origin=recordpage </a></td> </tr> <tr class="permanent_link"> <th>Permanent Link</th> <td> <a href="https://scholars.cityu.edu.hk/en/publications/publication(0caaf50d-306b-4a47-b378-9623a5a90303).html">https://scholars.cityu.edu.hk/en/publications/publication(0caaf50d-306b-4a47-b378-9623a5a90303).html</a></td> </tr> </table> </div> <div class="view-box"> <h2 class="subheader">Abstract</h2><div class="rendering rendering_researchoutput rendering_researchoutput_customabstractportal rendering_contributiontojournal rendering_customabstractportal rendering_contributiontojournal_customabstractportal"><div class="textblock">Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process that maintains cell balance in response to stress-related stimulation. Abnormal autophagy occurs with many pathologies, such as cancer, and autoimmune and neurodegenerative diseases. Hence, clarification of the mechanisms of autophagy regulation is of utmost importance. Recently, researchers presented microRNAs (miRNAs) as novel and potent modulators of autophagic activity. Here, we found that <i>Mir223 </i>deficiency significantly ameliorated CNS inflammation, demyelination and the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) and increased resting microglia and autophagy in brain microglial cells. In contrast, the autophagy inhibitor 3-methylademine (3-MA) aggravated the clinical symptoms of EAE in wild-type (WT) and <i>Mir223</i>-deficienct mice. Furthermore, it was confirmed that <i>Mir223 </i>deficiency in mice increased the protein expression of ATG16L1 (autophagy related 16-like 1 [S. cerevisiae]) and LC3-II in bone marrow-derived macrophage cells compared with cells from WT mice. Indeed, the cellular level of <i>Atg16l1 </i>was decreased in BV2 cells upon <i>Mir223 </i>overexpression and increased following the introduction of antagomirs. We also showed that the 3’ UTR of <i>Atg16l1 </i>contained functional <i>Mir223</i>-responsive sequences and that overexpression of ATG16L1 returned autophagy to normal levels even in the presence of <i>Mir223 </i>mimics. Collectively, these data indicate that <i>Mir223 </i>is a novel and important regulator of autophagy and that <i>Atg16l1 </i>is a <i>Mir223 </i>target in this process, which may have implications for improving our understanding of the neuroinflammatory process of EAE.</div></div> </div> <div class="view-box"> <h2 class="subheader">Research Area(s)</h2><div class="rendering rendering_keywordable rendering_keywordgroupsexcludecopyright rendering_keywordable_keywordgroupsexcludecopyright"><div class="keywordcontainers"><ul class="relations keywords"><li>ATG16L1, autophagy, CNS inflammation, experimental autoimmune encephalomyelitis, microglia, Mir223</li></ul></div><div class="sustainabledevelopmentgoals"><ul class="relations keywords"><li><strong><a href="https://scholars.cityu.edu.hk/en/publications/browse.html?uri=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Fgood_health_and_well_being&logicalname=sustainabledevelopmentgoals" class="link"><span>SDG 3 - Good Health and Well-being</span></a></strong></li></ul></div></div> </div> <div class="publication_related_concepts"> <div class="view_preview_panel"><script type="text/javascript" src="/resources/style/js/concept_tooltip.js?stamp=1731905518316"></script> <div class="relationlist for_publication_fingerprints"> <h2 class="section for_publication_fingerprints subheader"> Fingerprint </h2> <p class="portal_inline_help">Publication fingerprints text</p> <div class="concept_listing" data-content-id="26134367" data-locale="en_GB"> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=196544653" title="Autophagy in Biochemistry, Genetics and Molecular Biology has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">Autophagy</span> </span> <span class="concept_badge less_100" data-content-id="196544653" data-thesauri-acronym="Biochem_Genetics_MolBio"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">Biochemistry, Genetics an...</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=198023929" title="ATG16L1 in Biochemistry, Genetics and Molecular Biology has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">ATG16L1</span> </span> <span class="concept_badge less_100" data-content-id="198023929" data-thesauri-acronym="Biochem_Genetics_MolBio"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">Biochemistry, Genetics an...</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=196106927" title="Inflammation in Immunology and Microbiology has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">Inflammation</span> </span> <span class="concept_badge less_100" data-content-id="196106927" data-thesauri-acronym="Immunology_Microbiology"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">Immunology and Microbiolo...</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=196552008" title="Central Nervous System in Immunology and Microbiology has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">Central Nervous Sys...</span> </span> <span class="concept_badge less_100" data-content-id="196552008" data-thesauri-acronym="Immunology_Microbiology"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">Immunology and Microbiolo...</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=198023947" title="Central Nervous System Inflammation in Keyphrases has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">Central Nervous Sys...</span> </span> <span class="concept_badge less_100" data-content-id="198023947" data-thesauri-acronym="keyphrases"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">Keyphrases</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=198023958" title="MiR-223 in Keyphrases has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">MiR-223</span> </span> <span class="concept_badge less_100" data-content-id="198023958" data-thesauri-acronym="keyphrases"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">Keyphrases</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=197314565" title="Nervous System Inflammation in Pharmacology, Toxicology and Pharmaceutical Science has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">Nervous System Infl...</span> </span> <span class="concept_badge less_100" data-content-id="197314565" data-thesauri-acronym="Pharma_Tox"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">Pharmacology, Toxicology ...</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=198023985" title="Experimental Autoimmune Encephalomyelitis in Pharmacology, Toxicology and Pharmaceutical Science has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">Experimental Autoim...</span> </span> <span class="concept_badge less_100" data-content-id="198023985" data-thesauri-acronym="Pharma_Tox"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">Pharmacology, Toxicology ...</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=195913944" title="central nervous system in INIS has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">central nervous sys...</span> </span> <span class="concept_badge less_100" data-content-id="195913944" data-thesauri-acronym="inis"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">INIS</span> </span> </span> </div></span></a> </div> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=195913947" title="inflammation in INIS has a weight of 100%"><span> <div class="canvas-wrap"> <canvas class="canvas" width="50" height="50" data-procent="100"></canvas> <span class="procent">100</span> </div> <div class="finger-info"> <span class="title"> <span class="text">inflammation</span> </span> <span class="concept_badge less_100" data-content-id="195913947" data-thesauri-acronym="inis"> <span class="rating rank_100"><em></em></span> <span class="domain"> <span class="text">INIS</span> </span> </span> </div></span></a> </div> </div> <div class="concept_links"><a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303)/fingerprints.html"><span>Full Fingerprint ›</span></a> </div> </div> </div> </div> <div class="view-box citations"> <h2 class="subheader">Citation Format(s)</h2> <div class="tabs-container citations clear"> <ul class="citations"> <li class="selected"><a href="#">Standard</a></li> <li><a href="#">Harvard</a></li> <li><a href="#">APA</a></li> <li><a href="#">Vancouver</a></li> <li><a href="#">Author</a></li> </ul> <div class="cite-export"> <span class="publication_export">[ <a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).ris?download=true"><span>RIS</span></a> ]</span> <span class="publication_export">[ <a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).bibtex?download=true"><span>BibTeX</span></a> ]</span> </div> </div> <div class="citation-container"> <div class="view-box cite"><div class="rendering rendering_researchoutput rendering_researchoutput_standard rendering_contributiontojournal rendering_standard rendering_contributiontojournal_standard"><a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).html" class="link"><span><strong><i>Mir223 </i>restrains autophagy and promotes CNS inflammation by targeting ATG16L1.</strong></span></a> / Li, Yan; Zhou, Dongmei; Ren, Yinghui et al. <br />In: <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/autophagy(95977567-508e-4b30-9e3b-3027cb835dc3)/publications.html" class="link"><span>Autophagy</span></a>, Vol. 15, No. 3, 2019, p. 478–492.<p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Journal Publications and Reviews<span class="type_parent_sep"> › </span></span><span class="type_classification">RGC 21 - Publication in refereed journal</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> </div> <div class="view-box cite" style="display: none;"><div class="rendering rendering_researchoutput rendering_researchoutput_harvard rendering_contributiontojournal rendering_harvard rendering_contributiontojournal_harvard">Li, Y, Zhou, D, Ren, Y, Zhang, Z, Guo, X, Ma, M, Xue, Z, Lv, J, Liu, H, Xi, Q, Jia, L, Zhang, L, Liu, Y, Zhang, Q, Yan, J, Da, Y, Gao, F, Yue, J, Yao, Z & Zhang, R 2019, '<a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).html" class="link harvard_title"><span><i>Mir223 </i>restrains autophagy and promotes CNS inflammation by targeting ATG16L1</span></a>', <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/autophagy(95977567-508e-4b30-9e3b-3027cb835dc3)/publications.html" class="link"><span><em>Autophagy</em></span></a>, vol. 15, no. 3, pp. 478–492. <a onclick="window.open(this.href, '_blank','noopener,noreferrer'); return false;" href="https://doi.org/10.1080/15548627.2018.1522467" class="link"><span>https://doi.org/10.1080/15548627.2018.1522467</span></a></div> </div> <div class="view-box cite" style="display: none;"><div class="rendering rendering_researchoutput rendering_researchoutput_apa rendering_contributiontojournal rendering_apa rendering_contributiontojournal_apa">Li, Y., Zhou, D., Ren, Y., Zhang, Z., Guo, X., Ma, M., Xue, Z., Lv, J., Liu, H., Xi, Q., Jia, L., Zhang, L., Liu, Y., Zhang, Q., Yan, J., Da, Y., Gao, F., Yue, J., Yao, Z., & Zhang, R. (2019). <a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).html" class="link"><span><i>Mir223 </i>restrains autophagy and promotes CNS inflammation by targeting ATG16L1</span></a>. <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/autophagy(95977567-508e-4b30-9e3b-3027cb835dc3)/publications.html" class="link"><span><em>Autophagy</em></span></a>, <em>15</em>(3), 478–492. <a onclick="window.open(this.href, '_blank','noopener,noreferrer'); return false;" href="https://doi.org/10.1080/15548627.2018.1522467" class="link"><span>https://doi.org/10.1080/15548627.2018.1522467</span></a></div> </div> <div class="view-box cite" style="display: none;"><div class="rendering rendering_researchoutput rendering_researchoutput_vancouver rendering_contributiontojournal rendering_vancouver rendering_contributiontojournal_vancouver">Li Y, Zhou D, Ren Y, Zhang Z, Guo X, Ma M et al. <span class="title"><a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).html" class="link"><span><i>Mir223 </i>restrains autophagy and promotes CNS inflammation by targeting ATG16L1</span></a></span>. <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/autophagy(95977567-508e-4b30-9e3b-3027cb835dc3)/publications.html" class="link"><span>Autophagy</span></a>. 2019;15(3):478–492. Epub 2018 Sept 13. doi: 10.1080/15548627.2018.1522467</div> </div> <div class="view-box cite" style="display: none;"><div class="rendering rendering_researchoutput rendering_researchoutput_author rendering_contributiontojournal rendering_author rendering_contributiontojournal_author">Li, Yan ; Zhou, Dongmei ; Ren, Yinghui et al. / <a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/mir223-restrains-autophagy-and-promotes-cns-inflammation-by-targeting-atg16l1(0caaf50d-306b-4a47-b378-9623a5a90303).html" class="link"><span><strong><i>Mir223 </i>restrains autophagy and promotes CNS inflammation by targeting ATG16L1</strong></span></a>. In: <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/autophagy(95977567-508e-4b30-9e3b-3027cb835dc3)/publications.html" class="link"><span>Autophagy</span></a>. 2019 ; Vol. 15, No. 3. pp. 478–492.</div> </div> </div> </div> <div class="view-box"> <h2 class="subheader">Download Statistics</h2> <div class="chart-wrapper"><div class="portal_chart" id="j_id55192815_58308cc5" style="height: 300px;"><div class="portal_chart_empty"><span>No data available</span></div><div class="portal_chart_loading"></div></div><script type="text/javascript"> try {(function() { new portal.ChartUtil.renderChart({'element':'j_id55192815_58308cc5','dataSource':'',contentId:null,'chart':{title:{text:''},description:{text:''},categoryLabels:[{identity:'7\/2019',label:'Jul \'19'},{identity:'8\/2019',label:'Aug \'19'},{identity:'9\/2019',label:'Sep \'19'},{identity:'10\/2019',label:'Oct \'19'},{identity:'11\/2019',label:'Nov \'19'},{identity:'12\/2019',label:'Dec \'19'},{identity:'1\/2020',label:'Jan \'20'},{identity:'2\/2020',label:'Feb \'20'},{identity:'3\/2020',label:'Mar \'20'},{identity:'4\/2020',label:'Apr \'20'},{identity:'5\/2020',label:'May \'20'},{identity:'6\/2020',label:'Jun \'20'},{identity:'7\/2020',label:'Jul \'20'},{identity:'8\/2020',label:'Aug \'20'},{identity:'9\/2020',label:'Sep \'20'},{identity:'10\/2020',label:'Oct \'20'},{identity:'11\/2020',label:'Nov \'20'},{identity:'12\/2020',label:'Dec \'20'},{identity:'1\/2021',label:'Jan \'21'},{identity:'2\/2021',label:'Feb \'21'},{identity:'3\/2021',label:'Mar \'21'},{identity:'4\/2021',label:'Apr \'21'},{identity:'5\/2021',label:'May \'21'},{identity:'6\/2021',label:'Jun \'21'},{identity:'7\/2021',label:'Jul \'21'},{identity:'8\/2021',label:'Aug \'21'},{identity:'9\/2021',label:'Sep \'21'},{identity:'10\/2021',label:'Oct \'21'},{identity:'11\/2021',label:'Nov \'21'},{identity:'12\/2021',label:'Dec \'21'},{identity:'1\/2022',label:'Jan \'22'},{identity:'2\/2022',label:'Feb \'22'},{identity:'3\/2022',label:'Mar \'22'},{identity:'4\/2022',label:'Apr \'22'},{identity:'5\/2022',label:'May \'22'},{identity:'6\/2022',label:'Jun \'22'},{identity:'7\/2022',label:'Jul \'22'},{identity:'8\/2022',label:'Aug \'22'},{identity:'9\/2022',label:'Sep \'22'},{identity:'10\/2022',label:'Oct \'22'},{identity:'11\/2022',label:'Nov \'22'},{identity:'12\/2022',label:'Dec \'22'},{identity:'1\/2023',label:'Jan \'23'},{identity:'2\/2023',label:'Feb \'23'},{identity:'3\/2023',label:'Mar \'23'},{identity:'4\/2023',label:'Apr \'23'},{identity:'5\/2023',label:'May \'23'},{identity:'6\/2023',label:'Jun \'23'},{identity:'7\/2023',label:'Jul \'23'},{identity:'8\/2023',label:'Aug \'23'},{identity:'9\/2023',label:'Sep \'23'},{identity:'10\/2023',label:'Oct \'23'},{identity:'11\/2023',label:'Nov \'23'},{identity:'12\/2023',label:'Dec \'23'},{identity:'1\/2024',label:'Jan \'24'},{identity:'2\/2024',label:'Feb \'24'},{identity:'3\/2024',label:'Mar \'24'},{identity:'4\/2024',label:'Apr \'24'},{identity:'5\/2024',label:'May \'24'},{identity:'6\/2024',label:'Jun \'24'},{identity:'7\/2024',label:'Jul \'24'},{identity:'8\/2024',label:'Aug \'24'},{identity:'9\/2024',label:'Sep \'24'},{identity:'10\/2024',label:'Oct \'24'},{identity:'11\/2024',label:'Nov \'24'}],dataSets:[{type:'column',legend:'26134367.pdf (136)',entries:[{identity:'7\/2019',value:3},{identity:'8\/2019',value:3},{identity:'9\/2019',value:0},{identity:'10\/2019',value:0},{identity:'11\/2019',value:1},{identity:'12\/2019',value:2},{identity:'1\/2020',value:2},{identity:'2\/2020',value:1},{identity:'3\/2020',value:1},{identity:'4\/2020',value:2},{identity:'5\/2020',value:3},{identity:'6\/2020',value:1},{identity:'7\/2020',value:5},{identity:'8\/2020',value:8},{identity:'9\/2020',value:2},{identity:'10\/2020',value:2},{identity:'11\/2020',value:0},{identity:'12\/2020',value:0},{identity:'1\/2021',value:0},{identity:'2\/2021',value:2},{identity:'3\/2021',value:2},{identity:'4\/2021',value:2},{identity:'5\/2021',value:0},{identity:'6\/2021',value:0},{identity:'7\/2021',value:4},{identity:'8\/2021',value:4},{identity:'9\/2021',value:1},{identity:'10\/2021',value:2},{identity:'11\/2021',value:1},{identity:'12\/2021',value:1},{identity:'1\/2022',value:4},{identity:'2\/2022',value:1},{identity:'3\/2022',value:1},{identity:'4\/2022',value:1},{identity:'5\/2022',value:0},{identity:'6\/2022',value:0},{identity:'7\/2022',value:3},{identity:'8\/2022',value:3},{identity:'9\/2022',value:1},{identity:'10\/2022',value:0},{identity:'11\/2022',value:1},{identity:'12\/2022',value:1},{identity:'1\/2023',value:2},{identity:'2\/2023',value:1},{identity:'3\/2023',value:2},{identity:'4\/2023',value:1},{identity:'5\/2023',value:3},{identity:'6\/2023',value:1},{identity:'7\/2023',value:3},{identity:'8\/2023',value:2},{identity:'9\/2023',value:1},{identity:'10\/2023',value:1},{identity:'11\/2023',value:4},{identity:'12\/2023',value:2},{identity:'1\/2024',value:2},{identity:'2\/2024',value:4},{identity:'3\/2024',value:5},{identity:'4\/2024',value:6},{identity:'5\/2024',value:3},{identity:'6\/2024',value:6},{identity:'7\/2024',value:3},{identity:'8\/2024',value:7},{identity:'9\/2024',value:3},{identity:'10\/2024',value:2},{identity:'11\/2024',value:1}]}]},years:5,'includeCurrentYear':false,'categoryLabels':'years','chartDataSetType':'column','expandLegends':true,locales:['en_GB']}); })();} catch (e) {if (window['atira']) {atira.handleException(e);}} </script></div> </div> </div> </div> </div> <div class="footer"> <div class="wrapper"> <div class="cityu-scholar-footer-outbox"> <div class="cityu-scholar-footer-inbox"> <a href="https://www.cityu.edu.hk/cityu/privacy/index.htm" title="Footer Privacy Policy" target="_blank">Privacy Policy</a> | <a href="https://www.cityu.edu.hk/cityu/copyright/index.htm#copyright" title="Footer Copyright" target="_blank">Copyright</a> | <a href="https://www.cityu.edu.hk/cityu/disclaimer/index.htm#disclaimer" title="Footer Disclaimer" target="_blank">Disclaimer</a> | <a href="https://www.cityu.edu.hk/cityu/accessibility/" title="Footer Accessibility" target="_blank">Accessibility</a> | <a href="https://www.cityu.edu.hk/cityu/contactus/index.htm" title="Footer Contact Us" target="_blank">Contact Us</a><br /> © City University of Hong Kong. All Rights Reserved. </div> <div style="float:right;margin-top:45px;width:12%;"><img src="https://template.cityu.edu.hk/template/logo/CityU/CityU_Vertical_Logo_Reverse.svg" alt="" /></div> </div> <script src="https://www.cityu.edu.hk/scholars/portal/js/lib-js.js"></script> <script src="https://www.cityu.edu.hk/scholars/portal/js/cityu-cust.js"></script> </div> </div> <script async="true" src="//s7.addthis.com/js/300/addthis_widget.js#pubid=ra-586ef7fa1e60e604"></script></body></html>

CINXE.COM

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1 - CityU Scholars | A Research Hub of Excellence