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Declaration of Helsinki – WMA – The World Medical Association

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href='http://www.linkedin.com/shareArticle?mini=true&url=https://www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/'><i class='fa fa-linkedin' aria-hidden='true'></i></a></li><li><a target='_blank' class='social' href='http://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.wma.net%2Fwhat-we-do%2Fmedical-ethics%2Fdeclaration-of-helsinki%2F'><i class='fa fa-facebook' aria-hidden='true'></i></a></li><li><a target='_blank' class='social' href='mailto:?subject=Declaration of Helsinki&body=Declaration of Helsinkihttps://www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/'><i class='fa fa-envelope' aria-hidden='true'></i></a></li></ul></div></div><div class='col-sm-6 col-md-2 text-sm-left col-font-change no-padding'><ul id='font-change-list'><li><a href='#' class='icon-font' id='decrfont'><img src='https://www.wma.net/wp-content/themes/med/assets/img/icon/Decrease_Font.png'/></a></li><li><a href='#' class='icon-font' id='incrfont'><img src='https://www.wma.net/wp-content/themes/med/assets/img/icon/Increase_Font.png'/></a></li></ul></div></div></div> <div class="row row-main-content"> <div class="col-xs-12"> <header> <h1 class="page-header">Declaration of Helsinki</h1> <p class="page-summary">Medical Research Involving Human Participants</p> </header> <hr class="yellow-hr" /> <div class="row main-content-area"> <div class="col-sm-12 col-md-8"><p>The <a href="https://www.wma.net/policies-post/wma-declaration-of-helsinki/">Declaration of Helsinki (DoH)</a> is the World Medical Association&#8217;s (WMA) best-known policy statement. The first version was adopted in 1964 and has been amended seven times since, most recently at the General Assembly in October 2024. The current (2024) version is the only official one; all previous versions* have been replaced and should not be used or cited except for historical purposes. The WMA would like to thank all those who submitted comments and suggestions for the most recent revision of the DoH.</p> <p>In 2014, the WMA produced a celebratory publication to mark the 50th anniversary of the adoption of the Declaration of Helsinki. &#8220;The World Medical Association Declaration of Helsinki: 1964-2014 50 Years of Evolution of Medical Research Ethics&#8221; can be ordered online <a href="/wma?page_id=4591">here</a>.</p> <p>Since 2016, the <a href="https://www.wma.net/policies-post/wma-declaration-of-taipei-on-ethical-considerations-regarding-health-databases-and-biobanks/">Declaration of Taipei on Ethical Considerations regarding Health Databases and Biobanks</a> has complemented the Declaration of Helsinki.</p> <p><strong>Background</strong></p> <p>The World Medical Association developed the Declaration of Helsinki as a statement of ethical principles for medical research involving human participants following the atrocities by physicians conducting unethical medical research during the Second World War. Since the World Medical Association first adopted the Declaration of Helsinki in 1964, researchers, ethics review committees, and governments around the world now rely on the document’s high-level enduring principles to guide fundamental ethical considerations and decision-making.</p> <p>To ensure the Declaration of Helsinki, or DoH, continues to fulfill its purpose and to address evolving ethical challenges across the global research community, the World Medical Association invites periodic reviews of the document. Given the document was last updated in 2013, the World Medical Association appointed a workgroup to facilitate the last revision of the Declaration of Helsinki.</p> <p>The revision process was designed to be collaborative, transparent, and inclusive. The workgroup’s efforts were informed by regional and topical meetings spread over two and a half years, where issues were discussed by local and international experts and engaged audiences with diverse opinions. Resulting edits to the principles proposed by the workgroup were ultimately circulated worldwide for two public comment periods for feedback.</p> <p>&nbsp;</p> <p>*Currently the DoH is available in English only. The versions in the other WMA official languages (Spanish and French) are being refined and will be available as soon as this process is accomplished. We invite the members to share their translations in other languages (other than the three WMA official languages) so they can be listed here.</p> <p>&nbsp;</p> <p><span style="color: #ff0000"><strong>*Previous archived versions below are for research and information purpose only, use the updated version as reference.</strong></span></p> <ul> <li><a href="https://www.wma.net/wp-content/uploads/2018/07/DoH-Jun1964.pdf" target="_blank" rel="noopener noreferrer">Declaration of Helsinki &#8211; Version 1964</a></li> <li><a href="https://www.wma.net/wp-content/uploads/2018/07/DoH-Oct1975.pdf" target="_blank" rel="noopener noreferrer">Declaration of Helsinki &#8211; Version 1975</a></li> <li><a href="https://www.wma.net/wp-content/uploads/2018/07/DoH-Oct1983.pdf" target="_blank" rel="noopener noreferrer">Declaration of Helsinki &#8211; Version 1983</a></li> <li><a href="https://www.wma.net/wp-content/uploads/2018/07/DoH-Sept1989.pdf" target="_blank" rel="noopener noreferrer">Declaration of Helsinki &#8211; Version 1989</a></li> <li><a href="https://www.wma.net/wp-content/uploads/2018/07/DoH-Oct1996.pdf" target="_blank" rel="noopener noreferrer">Declaration of Helsinki &#8211; Version 1996</a></li> <li><a href="https://www.wma.net/wp-content/uploads/2018/07/DoH-Oct2000.pdf" target="_blank" rel="noopener noreferrer">Declaration of Helsinki &#8211; Version 2000</a></li> <li><a href="https://www.wma.net/wp-content/uploads/2018/07/DoH-Oct2004.pdf" target="_blank" rel="noopener noreferrer">Declaration of Helsinki &#8211; Version 2004</a></li> <li><a href="https://www.wma.net/wp-content/uploads/2018/07/DoH-Oct2008.pdf" target="_blank" rel="noopener noreferrer">Declaration of Helsinki &#8211; Version 2008</a></li> <li><a href="https://www.wma.net/wp-content/uploads/2024/10/DoH-Oct2013.pdf" target="_blank" rel="noopener">Declaration of Helsinki &#8211; Version 2013</a></li> </ul> </div> <div class="col-sm-12 col-md-4"> <div id="sidebarAccordion" role="tablist" aria-multiselectable="true"><div class="card"><div class="card-header" role="tab" id="heading-0"><h4><a class="collapse" data-toggle="collapse" data-parent="#sidebarAccordion" href="#content-0" aria-expanded="false" aria-controls="content-0">WMA Policy Resources</a></h4></div><div id="content-0" class="collapse" role="tabpanel" aria-labelledby="heading-0"><div class="card-block"><ul> <li><a href="https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/">Declaration of Helsinki </a></li> <li><a href="http://jamanetwork.com/journals/jama/fullarticle/1760318">JAMA Declaration of Helsinki </a> <ul> <li><a href="https://www.wma.net/wp-content/uploads/2016/11/DoH-Oct2013-JAMA.pdf">PDF Version </a></li> </ul> </li> <li><a href="https://www.wma.net/policies-post/wma-declaration-of-taipei-on-ethical-considerations-regarding-health-databases-and-biobanks/">Declaration of Taipei </a></li> </ul> </div></div></div><div class="card"><div class="card-header" role="tab" id="heading-1"><h4><a class="collapse" data-toggle="collapse" data-parent="#sidebarAccordion" href="#content-1" aria-expanded="false" aria-controls="content-1">Related Readings</a></h4></div><div id="content-1" class="collapse" role="tabpanel" aria-labelledby="heading-1"><div class="card-block"><ul> <li><a href="https://www.wma.net/wp-content/uploads/2024/10/Declaration-of-Helsinki-Revision-Process-2024.pdf" target="_blank" rel="noopener">Background information on the Declaration of Helsinki revision process</a></li> <li>See JAMA Viewpoint <a href="https://jamanetwork.com/journals/jama/fullarticle/2825289?guestAccessKey=ffb0d957-c087-4061-a22b-e1d9a2c07fbc&amp;utm_source=twitter&amp;utm_medium=social_jama&amp;utm_term=15014165025&amp;utm_campaign=article_alert&amp;linkId=627555211" target="_blank" rel="noopener"><em>Revisions to the Declaration of Helsinki on Its 60th Anniversary</em></a> <em>A Modernized Set of Ethical Principles to Promote and Ensure Respect for Participants in a Rapidly Innovating Medical Research Ecosystem</em>, by Dr Jack Resneck Jr.</li> <li>Listen to JAMA Author Interview with Dr Jack Resneck Jr. <a href="https://player.fm/series/jama-author-interviews/declaration-of-helsinki-addresses-new-ethical-challenges" target="_blank" rel="noopener">Declaration of Helsinki Addresses New Ethical Challenges</a></li> <li>See <a href="https://youtu.be/yHK2Re8UsOI" target="_blank" rel="noopener">WMA Declaration of Helsinki 2024 interview with Dr Jack Resneck Jr.</a></li> <li>See <a href="https://www.wma.net/news-post/revised-declaration-of-helsinki-adopted-by-the-global-medical-community-strengthening-ethical-standards-in-clinical-research-involving-humans/" target="_blank" rel="noopener">WMA Press release</a></li> </ul> </div></div></div></div> </div> </div> <div class="clr30"></div> <div class="page-children"> <div class="row"> <div class="col-sm-12 col-md-4 children-tile "> <a class="children-tile-wrapper" href="https://www.wma.net/what-we-do/medical-ethics/declaration-of-geneva/"> <div class="child-title"> <h3>Declaration of Geneva</h3> </div> <div class="child-summary">The "Modern Hippocratic Oath" </div> <div class="child-link text-xs-right"> Learn More </div> </a> </div> <div class="col-sm-12 col-md-4 children-tile active"> <a class="children-tile-wrapper" href="https://www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/"> <div class="child-title"> <h3>Declaration of Helsinki</h3> </div> <div class="child-summary">Medical Research Involving Human Participants </div> <div class="child-link text-xs-right"> Learn More </div> </a> </div> <div class="col-sm-12 col-md-4 children-tile "> <a class="children-tile-wrapper" href="https://www.wma.net/what-we-do/medical-ethics/declaration-of-tokyo/"> <div class="child-title"> <h3>Declaration of Tokyo</h3> </div> <div class="child-summary">Guidelines for Physicians to Prevent Torture </div> <div class="child-link text-xs-right"> Learn More </div> </a> </div> </div> <div class="row"> <div class="col-sm-12 col-md-4 children-tile "> <a class="children-tile-wrapper" href="https://www.wma.net/what-we-do/medical-ethics/declaration-of-taipei/"> <div class="child-title"> <h3>Declaration of Taipei</h3> </div> <div class="child-summary">Research on Health Databases, Big Data and Biobanks </div> <div class="child-link text-xs-right"> Learn More </div> </a> </div> </div> </div> </div> </div><!-- /.row-main --> </div> </div> <a href="#" class="scrollToTop"> <small>Back to Top</small> <div class="clearfix"></div> <i class="fa fa-arrow-up fa-2x" aria-hidden="true"></i> </a> <footer id="footer" class="container"> <hr class="yellow-hr"> <div class="row"> <div class="col-sm-12 col-md-10"> <a href="https://www.wma.net" class="footer-logo"><img src="https://www.wma.net/wp-content/themes/med/assets/img/logos/logo_footer.png" alt="WMA" /></a> <div class="footer-copyright"> &copy; 2024 World Medical 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