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Wu</title> <meta name="description" content="Search results for: Hongwei Wu"> <meta name="keywords" content="Hongwei Wu"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Hongwei Wu"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 8</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Hongwei Wu</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> A Framework for Embedding Industry 4.0 in the UAE Defence Manufacturing Industry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khalifa%20Al%20Baloushi">Khalifa Al Baloushi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongwei%20Zhang"> Hongwei Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Terrence%20Perera"> Terrence Perera</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Over the last few decades, the government of the UAE has been taking actions to consolidate defense manufacturing entities with the view to build a coherent and modern defense manufacturing base. Whilst these actions have significantly improved the overall capabilities of defense manufacturing; further opportunities exist to radically transform the sector. A comprehensive literature review and data collected from a survey identified three potential areas of improvements, (a) integration of Industry 4.0 technologies and other smart technologies, (b) stronger engagement of small and Medium-sized defense manufacturing companies and (c) Enhancing the national defense policies by embedding best practices from other nations. This research paper presents the design and development of a conceptual framework for the UAE defense industrial ecosystem. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=industry%204.0" title="industry 4.0">industry 4.0</a>, <a href="https://publications.waset.org/abstracts/search?q=defense%20manufacturing" title=" defense manufacturing"> defense manufacturing</a>, <a href="https://publications.waset.org/abstracts/search?q=eco-systems" title=" eco-systems"> eco-systems</a>, <a href="https://publications.waset.org/abstracts/search?q=integration" title=" integration"> integration</a> </p> <a href="https://publications.waset.org/abstracts/145808/a-framework-for-embedding-industry-40-in-the-uae-defence-manufacturing-industry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/145808.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">208</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Design of Reconfigurable Supernumerary Robotic Limb Based on Differential Actuated Joints</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Qinghua%20Zhang">Qinghua Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yanhe%20Zhu"> Yanhe Zhu</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiang%20Zhao"> Xiang Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Yeqin%20Yang"> Yeqin Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongwei%20Jing"> Hongwei Jing</a>, <a href="https://publications.waset.org/abstracts/search?q=Guoan%20Zhang"> Guoan Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jie%20Zhao"> Jie Zhao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents a wearable reconfigurable supernumerary robotic limb with differential actuated joints, which is lightweight, compact and comfortable for the wearers. Compared to the existing supernumerary robotic limbs which mostly adopted series structure with large movement space but poor carrying capacity, a prototype with the series-parallel configuration to better adapt to different task requirements has been developed in this design. To achieve a compact structure, two kinds of cable-driven mechanical structures based on guide pulleys and differential actuated joints were designed. Moreover, two different tension devices were also designed to ensure the reliability and accuracy of the cable-driven transmission. The proposed device also employed self-designed bearings which greatly simplified the structure and reduced the cost. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cable-driven" title="cable-driven">cable-driven</a>, <a href="https://publications.waset.org/abstracts/search?q=differential%20actuated%20joints" title=" differential actuated joints"> differential actuated joints</a>, <a href="https://publications.waset.org/abstracts/search?q=reconfigurable" title=" reconfigurable"> reconfigurable</a>, <a href="https://publications.waset.org/abstracts/search?q=supernumerary%20robotic%20limb" title=" supernumerary robotic limb"> supernumerary robotic limb</a> </p> <a href="https://publications.waset.org/abstracts/119868/design-of-reconfigurable-supernumerary-robotic-limb-based-on-differential-actuated-joints" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/119868.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">222</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Numerical and Experimental Studies on the Characteristic of the Air Distribution in the Wind-Box of a Circulating Fluidized Bed Boiler</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Xiaozhou%20Liu">Xiaozhou Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Guangyu%20Zhu"> Guangyu Zhu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu%20Zhang"> Yu Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongwei%20Wu"> Hongwei Wu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The wind-box is one of the important components of a Circulating Fluidized Bed (CFB) boiler. The uniformity of air flow in the wind-box of is very important for highly efficient operation of the CFB boiler. Non-uniform air flow distribution within the wind-box can reduce the boiler's thermal efficiency, leading to higher energy consumptions. An effective measure to solve this problem is to install an air flow distributing device in the wind-box. In order to validate the effectiveness of the air flow distributing device, visual and velocity distribution uniformity experiments have been carried out under five different test conditions by using a 1:64 scale model of a 220t/hr CFB boiler. It has been shown that the z component of flow velocity remains almost the same at control cross-sections of the wind-box, with a maximum variation of less than 10%. Moreover, the same methodology has been carried out to a full-scale 220t/hr CFB boiler. The hot test results depict that the thermal efficiency of the boiler has increased from 85.71% to 88.34% when tested with an air flow distributing device in place, which is equivalent to a saving of 5,000 tons of coal per year. The economic benefits of this energy-saving technology have been shown to be very significant, which clearly demonstrates that the technology is worth applying and popularizing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=circulating%20fluidized%20bed" title="circulating fluidized bed">circulating fluidized bed</a>, <a href="https://publications.waset.org/abstracts/search?q=CFB" title=" CFB"> CFB</a>, <a href="https://publications.waset.org/abstracts/search?q=wind-box" title=" wind-box"> wind-box</a>, <a href="https://publications.waset.org/abstracts/search?q=air%20flow%20distributing%20device" title=" air flow distributing device"> air flow distributing device</a>, <a href="https://publications.waset.org/abstracts/search?q=visual%20experiment" title=" visual experiment"> visual experiment</a>, <a href="https://publications.waset.org/abstracts/search?q=velocity%20distribution%20uniformity%20experiment" title=" velocity distribution uniformity experiment"> velocity distribution uniformity experiment</a>, <a href="https://publications.waset.org/abstracts/search?q=hot%20test" title=" hot test"> hot test</a> </p> <a href="https://publications.waset.org/abstracts/100840/numerical-and-experimental-studies-on-the-characteristic-of-the-air-distribution-in-the-wind-box-of-a-circulating-fluidized-bed-boiler" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100840.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">176</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Understanding Mathematics Achievements among U. S. Middle School Students: A Bayesian Multilevel Modeling Analysis with Informative Priors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jing%20Yuan">Jing Yuan</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongwei%20Yang"> Hongwei Yang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper aims to understand U.S. middle school students’ mathematics achievements by examining relevant student and school-level predictors. Through a variance component analysis, the study first identifies evidence supporting the use of multilevel modeling. Then, a multilevel analysis is performed under Bayesian statistical inference where prior information is incorporated into the modeling process. During the analysis, independent variables are entered sequentially in the order of theoretical importance to create a hierarchy of models. By evaluating each model using Bayesian fit indices, a best-fit and most parsimonious model is selected where Bayesian statistical inference is performed for the purpose of result interpretation and discussion. The primary dataset for Bayesian modeling is derived from the Program for International Student Assessment (PISA) in 2012 with a secondary PISA dataset from 2003 analyzed under the traditional ordinary least squares method to provide the information needed to specify informative priors for a subset of the model parameters. The dependent variable is a composite measure of mathematics literacy, calculated from an exploratory factor analysis of all five PISA 2012 mathematics achievement plausible values for which multiple evidences are found supporting data unidimensionality. The independent variables include demographics variables and content-specific variables: mathematics efficacy, teacher-student ratio, proportion of girls in the school, etc. Finally, the entire analysis is performed using the MCMCpack and MCMCglmm packages in R. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bayesian%20multilevel%20modeling" title="Bayesian multilevel modeling">Bayesian multilevel modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematics%20education" title=" mathematics education"> mathematics education</a>, <a href="https://publications.waset.org/abstracts/search?q=PISA" title=" PISA"> PISA</a>, <a href="https://publications.waset.org/abstracts/search?q=multilevel" title=" multilevel"> multilevel</a> </p> <a href="https://publications.waset.org/abstracts/67623/understanding-mathematics-achievements-among-u-s-middle-school-students-a-bayesian-multilevel-modeling-analysis-with-informative-priors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67623.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">336</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Research on Container Housing: A New Form of Informal Housing on Urban Temporary Land</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lufei%20Mao">Lufei Mao</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongwei%20Chen"> Hongwei Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Zijiao%20Chai"> Zijiao Chai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Informal housing is a widespread phenomenon in developing countries. In many newly-emerging cities in China, rapid urbanization leads to an influx of population as well as a shortage of housing. Under this background, container housing, a new form of informal housing, gradually appears on a small scale on urban temporary land in recent years. Container housing, just as its name implies, transforms containers into small houses that allow migrant workers group to live in it. Scholars in other countries have established sound theoretical frameworks for informal housing study, but the research fruits seem rather limited on this small scale housing form. Unlike the cases in developed countries, these houses, which are outside urban planning, bring about various environmental, economic, social and governance issues. Aiming to figure out this new-born housing form, a survey mainly on two container housing settlements in Hangzhou, China was carried out to gather the information of them. Based on this thorough survey, the paper concludes the features and problems of infrastructure, environment and social communication of container housing settlements. The result shows that these containers were lacking of basic facilities and were restricted in a small mess temporary land. Moreover, because of the deficiency in management, the rental rights of these containers might not be guaranteed. Then the paper analyzes the factors affecting the formation and evolution of container housing settlements. It turns out that institutional and policy factors, market factors and social factors were the main three factors that affect the formation. At last, the paper proposes some suggestions for the governance of container housing and the utility pattern of urban temporary land. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=container%20housing" title="container housing">container housing</a>, <a href="https://publications.waset.org/abstracts/search?q=informal%20housing" title=" informal housing"> informal housing</a>, <a href="https://publications.waset.org/abstracts/search?q=urban%20temporary%20land" title=" urban temporary land"> urban temporary land</a>, <a href="https://publications.waset.org/abstracts/search?q=urban%20governance" title=" urban governance"> urban governance</a> </p> <a href="https://publications.waset.org/abstracts/71245/research-on-container-housing-a-new-form-of-informal-housing-on-urban-temporary-land" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71245.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">257</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Relative Entropy Used to Determine the Divergence of Cells in Single Cell RNA Sequence Data Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=An%20Chengrui">An Chengrui</a>, <a href="https://publications.waset.org/abstracts/search?q=Yin%20Zi"> Yin Zi</a>, <a href="https://publications.waset.org/abstracts/search?q=Wu%20Bingbing"> Wu Bingbing</a>, <a href="https://publications.waset.org/abstracts/search?q=Ma%20Yuanzhu"> Ma Yuanzhu</a>, <a href="https://publications.waset.org/abstracts/search?q=Jin%20Kaixiu"> Jin Kaixiu</a>, <a href="https://publications.waset.org/abstracts/search?q=Chen%20Xiao"> Chen Xiao</a>, <a href="https://publications.waset.org/abstracts/search?q=Ouyang%20Hongwei"> Ouyang Hongwei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Single cell RNA sequence (scRNA-seq) is one of the effective tools to study transcriptomics of biological processes. Recently, similarity measurement of cells is Euclidian distance or its derivatives. However, the process of scRNA-seq is a multi-variate Bernoulli event model, thus we hypothesize that it would be more efficient when the divergence between cells is valued with relative entropy than Euclidian distance. In this study, we compared the performances of Euclidian distance, Spearman correlation distance and Relative Entropy using scRNA-seq data of the early, medial and late stage of limb development generated in our lab. Relative Entropy is better than other methods according to cluster potential test. Furthermore, we developed KL-SNE, an algorithm modifying t-SNE whose definition of divergence between cells Euclidian distance to Kullback–Leibler divergence. Results showed that KL-SNE was more effective to dissect cell heterogeneity than t-SNE, indicating the better performance of relative entropy than Euclidian distance. Specifically, the chondrocyte expressing Comp was clustered together with KL-SNE but not with t-SNE. Surprisingly, cells in early stage were surrounded by cells in medial stage in the processing of KL-SNE while medial cells neighbored to late stage with the process of t-SNE. This results parallel to Heatmap which showed cells in medial stage were more heterogenic than cells in other stages. In addition, we also found that results of KL-SNE tend to follow Gaussian distribution compared with those of the t-SNE, which could also be verified with the analysis of scRNA-seq data from another study on human embryo development. Therefore, it is also an effective way to convert non-Gaussian distribution to Gaussian distribution and facilitate the subsequent statistic possesses. Thus, relative entropy is potentially a better way to determine the divergence of cells in scRNA-seq data analysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Single%20cell%20RNA%20sequence" title="Single cell RNA sequence">Single cell RNA sequence</a>, <a href="https://publications.waset.org/abstracts/search?q=Similarity%20measurement" title=" Similarity measurement"> Similarity measurement</a>, <a href="https://publications.waset.org/abstracts/search?q=Relative%20Entropy" title=" Relative Entropy"> Relative Entropy</a>, <a href="https://publications.waset.org/abstracts/search?q=KL-SNE" title=" KL-SNE"> KL-SNE</a>, <a href="https://publications.waset.org/abstracts/search?q=t-SNE" title=" t-SNE"> t-SNE</a> </p> <a href="https://publications.waset.org/abstracts/63441/relative-entropy-used-to-determine-the-divergence-of-cells-in-single-cell-rna-sequence-data-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63441.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">340</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Ethicality of Algorithmic Pricing and Consumers’ Resistance</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zainab%20Atia">Zainab Atia</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongwei%20He"> Hongwei He</a>, <a href="https://publications.waset.org/abstracts/search?q=Panagiotis%20Sarantopoulos"> Panagiotis Sarantopoulos</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Over the past few years, firms have witnessed a massive increase in sophisticated algorithmic deployment, which has become quite pervasive in today’s modern society. With the wide availability of data for retailers, the ability to track consumers using algorithmic pricing has become an integral option in online platforms. As more companies are transforming their businesses and relying more on massive technological advancement, pricing algorithmic systems have brought attention and given rise to its wide adoption, with many accompanying benefits and challenges to be found within its usage. With the overall aim of increasing profits by organizations, algorithmic pricing is becoming a sound option by enabling suppliers to cut costs, allowing better services, improving efficiency and product availability, and enhancing overall consumer experiences. The adoption of algorithms in retail has been pioneered and widely used in literature across varied fields, including marketing, computer science, engineering, economics, and public policy. However, what is more, alarming today is the comprehensive understanding and focus of this technology and its associated ethical influence on consumers’ perceptions and behaviours. Indeed, due to algorithmic ethical concerns, consumers are found to be reluctant in some instances to share their personal data with retailers, which reduces their retention and leads to negative consumer outcomes in some instances. This, in its turn, raises the question of whether firms can still manifest the acceptance of such technologies by consumers while minimizing the ethical transgressions accompanied by their deployment. As recent modest research within the area of marketing and consumer behavior, the current research advances the literature on algorithmic pricing, pricing ethics, consumers’ perceptions, and price fairness literature. With its empirical focus, this paper aims to contribute to the literature by applying the distinction of the two common types of algorithmic pricing, dynamic and personalized, while measuring their relative effect on consumers’ behavioural outcomes. From a managerial perspective, this research offers significant implications that pertain to providing a better human-machine interactive environment (whether online or offline) to improve both businesses’ overall performance and consumers’ wellbeing. Therefore, by allowing more transparent pricing systems, businesses can harness their generated ethical strategies, which fosters consumers’ loyalty and extend their post-purchase behaviour. Thus, by defining the correct balance of pricing and right measures, whether using dynamic or personalized (or both), managers can hence approach consumers more ethically while taking their expectations and responses at a critical stance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=algorithmic%20pricing" title="algorithmic pricing">algorithmic pricing</a>, <a href="https://publications.waset.org/abstracts/search?q=dynamic%20pricing" title=" dynamic pricing"> dynamic pricing</a>, <a href="https://publications.waset.org/abstracts/search?q=personalized%20pricing" title=" personalized pricing"> personalized pricing</a>, <a href="https://publications.waset.org/abstracts/search?q=price%20ethicality" title=" price ethicality"> price ethicality</a> </p> <a href="https://publications.waset.org/abstracts/152296/ethicality-of-algorithmic-pricing-and-consumers-resistance" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152296.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">92</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Regulation of Desaturation of Fatty Acid and Triglyceride Synthesis by Myostatin through Swine-Specific MEF2C/miR222/SCD5 Pathway</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wei%20Xiao">Wei Xiao</a>, <a href="https://publications.waset.org/abstracts/search?q=Gangzhi%20Cai"> Gangzhi Cai</a>, <a href="https://publications.waset.org/abstracts/search?q=Xingliang%20Qin"> Xingliang Qin</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongyan%20Ren"> Hongyan Ren</a>, <a href="https://publications.waset.org/abstracts/search?q=Zaidong%20Hua"> Zaidong Hua</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhe%20Zhu"> Zhe Zhu</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongwei%20Xiao"> Hongwei Xiao</a>, <a href="https://publications.waset.org/abstracts/search?q=Ximin%20Zheng"> Ximin Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Jie%20Yao"> Jie Yao</a>, <a href="https://publications.waset.org/abstracts/search?q=Yanzhen%20Bi"> Yanzhen Bi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Myostatin (MSTN) is the master regulator of double muscling phenotype with overgrown muscle and decreased fatness in animals, but its action mode to regulate fat deposition remains to be elucidated. In this study a swin-specific pathway through which MSTN acts to regulate the fat deposition was deciphered. Deep sequenincing of the mRNA and miRNA of fat tissues of MSTN knockout (KO) and wildtype (WT) pigs discovered the positive correlation of myocyte enhancer factor 2C (MEF2C) and fat-inhibiting miR222 expression, and the inverse correlation of miR222 and stearoyl-CoA desaturase 5 (SCD5) expression. SCD5 is rodent-absent and expressed only in pig, sheep and cattle. Fatty acid spectrum of fat tissues revealed a lower percentage of oleoyl-CoA (18:1) and palmitoleyl CoA (16:1) in MSTN KO pigs, which are the catalyzing products of SCD5-mediated desaturation of steroyl CoA (18:0) and palmitoyl CoA (16:0). Blood metrics demonstrated a 45% decline of triglyceride (TG) content in MSTN KO pigs. In light of these observations we hypothesized that MSTN might act through MEF2C/miR222/SCD5 pathway to regulate desaturation of fatty acid as well as triglyceride synthesis in pigs. To this end, real-time PCR and Western blotting were carried out to detect the expression of the three genes stated above. These experiments showed that MEF2C expression was up-regulated by nearly 2-fold, miR222 up-regulated by nearly 3-fold and SCD5 down-regulated by nearly 50% in MSTN KO pigs. These data were consistent with the expression change in deep sequencing analysis. Dual luciferase reporter was then used to confirm the regulation of MEF2C upon the promoter of miR222. Ecotopic expression of MEF2C in preadipocyte cells enhanced miR222 expression by 3.48-fold. CHIP-PCR identified a putative binding site of MEF2C on -2077 to -2066 region of miR222 promoter. Electrophoretic mobility shift assay (EMSA) demonstrated the interaction of MEF2C and miR222 promoter in vitro. These data indicated that MEF2C transcriptionally regulates the expression of miR222. Next, the regulation of miR222 on SCD5 mRNA as well as its physiological consequences were examined. Dual luciferase reporter testing revealed the translational inhibition of miR222 upon the 3´ UTR (untranslated region) of SCD5 in preadipocyte cells. Transfection of miR222 mimics and inhibitors resulted in the down-regulation and up-regulation of SCD5 in preadipocyte cells respectively, consistent with the results from reporter testing. RNA interference of SCD5 in preadipocyte cells caused 26.2% reduction of TG, in agreement with the results of TG content in MSTN KO pigs. In summary, the results above supported the existence of a molecular pathway that MSTN signals through MEF2C/miR222/SCD5 to regulate the fat deposition in pigs. This swine-specific pathway offers potential molecular markers for the development and breeding of a new pig line with optimised fatty acid composition. This would benefit human health by decreasing the takeup of saturated fatty acid. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fat%20deposition" title="fat deposition">fat deposition</a>, <a href="https://publications.waset.org/abstracts/search?q=MEF2C" title=" MEF2C"> MEF2C</a>, <a href="https://publications.waset.org/abstracts/search?q=miR222" title=" miR222"> miR222</a>, <a href="https://publications.waset.org/abstracts/search?q=myostatin" title=" myostatin"> myostatin</a>, <a href="https://publications.waset.org/abstracts/search?q=SCD5" title=" SCD5"> SCD5</a>, <a href="https://publications.waset.org/abstracts/search?q=pig" title=" pig"> pig</a> </p> <a href="https://publications.waset.org/abstracts/103392/regulation-of-desaturation-of-fatty-acid-and-triglyceride-synthesis-by-myostatin-through-swine-specific-mef2cmir222scd5-pathway" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/103392.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">130</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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