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In a syngeneic model, the tumor tissue was obtained from a mouse of the same genetic background as the immuno-competent recipient mouse. With the tumor microenvironment and transplanted cells belonging to the same strain, syngeneic models are powerful immuno-oncology models for investigating responses to anti-cancer therapies.</p> <p>Our panel of cell line-derived syngeneic tumor models (CDX) comprises subcutaneous, subQperior, orthotopic, and metastasis models. Our <a href="https://www.reactionbiology.com/services/in-vivo-pharmacology/immuno-oncology-tumor-models/subqperiortm-panel-screen">innovative subQperior<sup>TM</sup> tumor models</a> are based on cell implantation into the mammary fat pad of mice and feature reduced tumor ulceration and yield more homogeneous tumor growth and ultimately outstanding statistical evaluation of drug efficacy testing.</p> <p>In addition to standard syngeneic tumor models, Reaction Biology also offers proprietary tissue-based immuno-oncology models, named <a href="/services/in-vivo-pharmacology/immuno-oncology-tumor-models/mouse-derived-isograft-tumor-models-mdi/">Mouse-derived Isograft Models (MDI)</a>.</p> <ul> <li>Science-driven study setup with a focus on reproducible and meaningful results</li> <li>Custom-tailored reports written by Ph.D. level medical writers will be provided for every in vivo study</li> <li>All procedures entail a meticulous documentation process according to GV-Solas requirements and are in-line with the ISO 9001 certification</li> <li>Regular syngeneic <a href="/services/in-vivo-pharmacology/immuno-oncology-tumor-models/subqperiortm-panel-screen/">panel screening</a> of 6 syngeneic tumor models for economic efficacy evaluation of new immuno-oncology drug candidates</li> <li>Comprehensive <a href="/services/biomarker-discovery/immunophenotyping/flow-cytometry/">flow cytometry analysis</a> capacity with 17 marker staining panel</li> </ul> <p>Reaction Biology has a global network of business development managers to understand your specific research needs and help determine the right mouse models for your immunotherapy research thrust. 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paragraph--view-mode--default"><div id="smm-id" class="paragraph table-search excel-export paragraph--type--table-one paragraph--view-mode--default"><div class="container center"><h2>Cell line-derived Syngeneic Mouse Models</h2> <div class="field field--name-field-table-one field--type-tablefield field--label-hidden field__item"> <div id="tablefield-wrapper-paragraph-2346-field_table_one-0" class="tablefield-wrapper"> <div id="tablefield-paragraph-2346-field_table_one-0_wrapper" class="dataTables_wrapper no-footer"> <table id="tablefield-paragraph-2346-field_table_one-0" class="tablefield dataTable no-footer dtr-inline" role="grid" data-striping="1"> <caption>Cell line-derived Syngeneic Mouse Models</caption> <thead> <tr role="row"> <th class="row_0 col_0 all control sorting_asc" tabindex="0" colspan="1" rowspan="1" aria-controls="tablefield-paragraph-2346-field_table_one-0" aria-sort="ascending" aria-label="Cell Line: activate to sort column descending">Cell Line</th> <th class="row_0 col_1 min-fablet sorting" tabindex="0" colspan="1" rowspan="1" aria-controls="tablefield-paragraph-2346-field_table_one-0" aria-label="Tissue Orgin: activate to sort column ascending">Tissue Orgin</th> <th class="row_0 col_2 min-fablet sorting" tabindex="0" colspan="1" rowspan="1" aria-controls="tablefield-paragraph-2346-field_table_one-0" aria-label="Disease: activate to sort column ascending">Disease</th> <th class="row_0 col_3 min-tablet sorting" tabindex="0" colspan="1" rowspan="1" aria-controls="tablefield-paragraph-2346-field_table_one-0" aria-label="Available Models at Hershey, PA, USA: activate to sort column ascending">Available Models at Hershey, PA, USA</th> <th class="row_0 col_4 min-desktop sorting" tabindex="0" colspan="1" rowspan="1" aria-controls="tablefield-paragraph-2346-field_table_one-0" aria-label="Available Models at Freiburg, Germany: activate to sort column ascending">Available Models at Freiburg, Germany</th> </tr> </thead> <tbody> <tr class="odd" role="row"> <td class="row_19 col_0 all control sorting_1" tabindex="0">3LL</td> <td class="row_19 col_1 min-fablet">Lung</td> <td class="row_19 col_2 min-fablet">Lewis lung carcinoma</td> <td class="row_19 col_3 min-tablet">subcutaneous</td> <td class="row_19 col_4 min-desktop"></td> </tr> <tr class="even" role="row"> <td class="row_1 col_0 all control sorting_1" tabindex="0">4T1</td> <td class="row_1 col_1 min-fablet">Breast</td> <td class="row_1 col_2 min-fablet">Malignant neoplasms of the mouse mammary gland</td> <td class="row_1 col_3 min-tablet">subcutaneous; orthotopic</td> <td class="row_1 col_4 link_text min-desktop"><a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/4T1_subQperior_ortho.pdf" target="_blank" rel="noopener">subQperior_orthotopic; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/4T1_metastasis_ortho.pdf" target="_blank" rel="noopener">metastasis (orthotopic); </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/4T1_metastasis_iv.pdf" target="_blank" rel="noopener">metastasis (i.v.)</a></td> </tr> <tr class="odd" role="row"> <td class="row_20 col_0 all control sorting_1" tabindex="0">A20</td> <td class="row_20 col_1 min-fablet">Blood</td> <td class="row_20 col_2 min-fablet">B cell lymphoma</td> <td class="row_20 col_3 min-tablet">subcutaneous</td> <td class="row_20 col_4 min-desktop"></td> </tr> <tr class="even" role="row"> <td class="row_2 col_0 all control sorting_1" tabindex="0">AB12</td> <td class="row_2 col_1 min-fablet">Lung</td> <td class="row_2 col_2 min-fablet">Mesothelioma</td> <td class="row_2 col_3 min-tablet">–</td> <td class="row_2 col_4 link_text min-desktop">subcutaneous*; <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/AB12_subQperior.pdf" target="_blank" rel="noopener">subQperior</a></td> </tr> <tr class="odd" role="row"> <td class="row_3 col_0 all control sorting_1" tabindex="0">B16-F0</td> <td class="row_3 col_1 min-fablet">Skin</td> <td class="row_3 col_2 min-fablet">Melanoma</td> <td class="row_3 col_3 min-tablet">subcutaneous</td> <td class="row_3 col_4 min-desktop">–</td> </tr> <tr class="even" role="row"> <td class="row_4 col_0 all control sorting_1" tabindex="0">B16-F10</td> <td class="row_4 col_1 min-fablet">Skin</td> <td class="row_4 col_2 min-fablet">Melanoma</td> <td class="row_4 col_3 min-tablet">subcutaneous; orthotopic; metastasis (i.c.); metastasis (i.v.)</td> <td class="row_4 col_4 link_text min-desktop"><a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/B16-F10_subcutaneous.pdf" target="_blank" rel="noopener">subcutaneous; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/B16-F10_subQperior.pdf" target="_blank" rel="noopener">subQperior; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/B16-F10_ortho.pdf" target="_blank" rel="noopener">orthotopic; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/B16-F10_metastasis_iv.pdf" target="_blank" rel="noopener">metastasis (i.v.)</a></td> </tr> <tr class="odd" role="row"> <td class="row_5 col_0 all control sorting_1" tabindex="0">C1498</td> <td class="row_5 col_1 min-fablet">Blood</td> <td class="row_5 col_2 min-fablet">Acute myeloid leukemia, lymphoblast</td> <td class="row_5 col_3 min-tablet">subcutaneous; metastasis (i.v.)</td> <td class="row_5 col_4 min-desktop">–</td> </tr> <tr class="even" role="row"> <td class="row_6 col_0 all control sorting_1" tabindex="0">Clone M3/Cloudman S91</td> <td class="row_6 col_1 min-fablet">Skin</td> <td class="row_6 col_2 min-fablet">Melanoma</td> <td class="row_6 col_3 min-tablet">–</td> <td class="row_6 col_4 link_text min-desktop">subcutaneous*; <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/CloneM3_subQperior.pdf" target="_blank" rel="noopener">subQperior</a></td> </tr> <tr class="odd" role="row"> <td class="row_7 col_0 all control sorting_1" tabindex="0">CT26wt</td> <td class="row_7 col_1 min-fablet">Colon</td> <td class="row_7 col_2 min-fablet">Colon adenocarcinoma</td> <td class="row_7 col_3 min-tablet">subcutaneous</td> <td class="row_7 col_4 link_text min-desktop"><a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/CT26wt_subcutaneous.pdf" target="_blank" rel="noopener">subcutaneous; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/CT26wt_subQperior.pdf" target="_blank" rel="noopener">subQperior; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/CT26wt_ortho.pdf" target="_blank" rel="noopener">orthotopic</a></td> </tr> <tr class="even" role="row"> <td class="row_8 col_0 all control sorting_1" tabindex="0">E.G7-OVA</td> <td class="row_8 col_1 min-fablet">Blood</td> <td class="row_8 col_2 min-fablet">T lymphoblast</td> <td class="row_8 col_3 min-tablet">subcutaneous</td> <td class="row_8 col_4 min-desktop">–</td> </tr> <tr class="odd" role="row"> <td class="row_21 col_0 all control sorting_1" tabindex="0">EL4</td> <td class="row_21 col_1 min-fablet">Blood</td> <td class="row_21 col_2 min-fablet">T lymphoblast</td> <td class="row_21 col_3 min-tablet">subcutaneous</td> <td class="row_21 col_4 min-desktop"></td> </tr> <tr class="even" role="row"> <td class="row_9 col_0 all control sorting_1" tabindex="0">EMT6</td> <td class="row_9 col_1 min-fablet">Breast</td> <td class="row_9 col_2 min-fablet">Breast carcinoma</td> <td class="row_9 col_3 min-tablet">subcutaneous; orthotopic</td> <td class="row_9 col_4 link_text min-desktop">subcutaneous*; <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/EMT6_subQperior_ortho.pdf" target="_blank" rel="noopener">subQperior (orthotopic)</a></td> </tr> <tr class="odd" role="row"> <td class="row_22 col_0 all control sorting_1" tabindex="0">EO771</td> <td class="row_22 col_1 min-fablet">Breast</td> <td class="row_22 col_2 min-fablet">Breast carcinoma</td> <td class="row_22 col_3 min-tablet">orthotopic</td> <td class="row_22 col_4 min-desktop"></td> </tr> <tr class="even" role="row"> <td class="row_10 col_0 all control sorting_1" tabindex="0">GL261</td> <td class="row_10 col_1 min-fablet">Brain</td> <td class="row_10 col_2 min-fablet">Glioblastoma</td> <td class="row_10 col_3 min-tablet">–</td> <td class="row_10 col_4 min-desktop">subcutaneous; <a class="link_text" href="https://www.reactionbiology.com/sites/default/files/datasheets/GL261_ortho_freiburg.pdf" target="_blank" rel="noopener">orthotopic</a></td> </tr> <tr class="odd" role="row"> <td class="row_11 col_0 all control sorting_1" tabindex="0">HC11-NeuT</td> <td class="row_11 col_1 min-fablet">Breast</td> <td class="row_11 col_2 min-fablet">Breast epithelial cell line transformed with NeuT (rat ErbB2 homolog)</td> <td class="row_11 col_3 min-tablet">orthotopic</td> <td class="row_11 col_4 min-desktop">–</td> </tr> <tr class="even" role="row"> <td class="row_12 col_0 all control sorting_1" tabindex="0">Hepa1-6</td> <td class="row_12 col_1 min-fablet">Liver</td> <td class="row_12 col_2 min-fablet">Hepatocellular carcinoma</td> <td class="row_12 col_3 min-tablet">subcutaneous; orthotopic</td> <td class="row_12 col_4 link_text min-desktop"><a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/HEPA1-6_subQperior.pdf" target="_blank" rel="noopener">subQperior; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/HEPA1-6_ortho.pdf" target="_blank" rel="noopener">orthotopic </a></td> </tr> <tr class="odd" role="row"> <td class="row_23 col_0 all control sorting_1" tabindex="0">KPC-2838</td> <td class="row_23 col_1 min-fablet">Pancreas</td> <td class="row_23 col_2 min-fablet">Pancreatic cancer</td> <td class="row_23 col_3 min-tablet">subcutaneous</td> <td class="row_23 col_4 min-desktop"></td> </tr> <tr class="even" role="row"> <td class="row_24 col_0 all control sorting_1" tabindex="0">KPC-6419</td> <td class="row_24 col_1 min-fablet">Pancreas</td> <td class="row_24 col_2 min-fablet">Pancreatic cancer</td> <td class="row_24 col_3 min-tablet">subcutaneous</td> <td class="row_24 col_4 min-desktop"></td> </tr> <tr class="odd" role="row"> <td class="row_13 col_0 all control sorting_1" tabindex="0">LL/2 (LLC1)</td> <td class="row_13 col_1 min-fablet">Lung</td> <td class="row_13 col_2 min-fablet">Lewis lung carcinoma</td> <td class="row_13 col_3 min-tablet">subcutaneous</td> <td class="row_13 col_4 link_text min-desktop">subcutaneous*; <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/LL-2_subQperior.pdf" target="_blank" rel="noopener">subQperior; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/LL-2_ortho.pdf" target="_blank" rel="noopener">orthotopic</a></td> </tr> <tr class="even" role="row"> <td class="row_25 col_0 all control sorting_1" tabindex="0">M109</td> <td class="row_25 col_1 min-fablet">Lung</td> <td class="row_25 col_2 min-fablet">Spontaneous murine lung carcinoma</td> <td class="row_25 col_3 min-tablet">subcutaneous</td> <td class="row_25 col_4 min-desktop"></td> </tr> <tr class="odd" role="row"> <td class="row_14 col_0 all control sorting_1" tabindex="0">MB-49</td> <td class="row_14 col_1 min-fablet">Bladder</td> <td class="row_14 col_2 min-fablet">Urinary bladder carcinoma</td> <td class="row_14 col_3 min-tablet">subcutaneous; orthotopic; metastasis (i.c.); metastasis (i.v.)</td> <td class="row_14 col_4 min-desktop">–</td> </tr> <tr class="even" role="row"> <td class="row_26 col_0 all control sorting_1" tabindex="0">MBT-2</td> <td class="row_26 col_1 min-fablet">Bladder</td> <td class="row_26 col_2 min-fablet">Urinary Bladder carcinoma</td> <td class="row_26 col_3 min-tablet">subcutaneous</td> <td class="row_26 col_4 min-desktop"></td> </tr> <tr class="odd" role="row"> <td class="row_15 col_0 all control sorting_1" tabindex="0">MC-38</td> <td class="row_15 col_1 min-fablet">Colon</td> <td class="row_15 col_2 min-fablet">Colon adenocarcinoma</td> <td class="row_15 col_3 min-tablet">subcutaneous</td> <td class="row_15 col_4 min-desktop">–</td> </tr> <tr class="even" role="row"> <td class="row_16 col_0 all control sorting_1" tabindex="0">MC38-CEA#</td> <td class="row_16 col_1 min-fablet">Colon</td> <td class="row_16 col_2 min-fablet">Colon adenocarcinoma</td> <td class="row_16 col_3 min-tablet">–</td> <td class="row_16 col_4 link_text min-desktop">subcutaneous*; <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/MC38-CEA_subQperior.pdf" target="_blank" rel="noopener">subQperior; </a> orthotopic</td> </tr> <tr class="odd" role="row"> <td class="row_17 col_0 all control sorting_1" tabindex="0">Pan02</td> <td class="row_17 col_1 min-fablet">Pancreas</td> <td class="row_17 col_2 min-fablet">Pancreatic ductal adenocarcinoma</td> <td class="row_17 col_3 min-tablet">subcutaneous; orthotopic</td> <td class="row_17 col_4 min-desktop">subQperior; orthotopic</td> </tr> <tr class="even" role="row"> <td class="row_18 col_0 all control sorting_1" tabindex="0">RENCA</td> <td class="row_18 col_1 min-fablet">Kidney</td> <td class="row_18 col_2 min-fablet">Kidney carcinoma</td> <td class="row_18 col_3 min-tablet">subcutaneous</td> <td class="row_18 col_4 link_text min-desktop">subcutaneous*; <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/RENCA_subQperior.pdf" target="_blank" rel="noopener">subQperior; </a> <a class="link_text" href="https://www.reactionbiology.com/wp-content/uploads/2023/07/RENCA_ortho.pdf" target="_blank" rel="noopener">orthotopic</a></td> </tr> <tr class="odd" role="row"> <td class="row_27 col_0 all control sorting_1" tabindex="0">TC-1</td> <td class="row_27 col_1 min-fablet">Lung</td> <td class="row_27 col_2 min-fablet">Primary lung epithelial cells</td> <td class="row_27 col_3 min-tablet">subcutaneous</td> <td class="row_27 col_4 min-desktop"></td> </tr> </tbody> </table> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__items"> <p>* subQperior substitute subcutaneous tumor models<br /> # Carcinoembryonic antigen suited for the investigation of tumor-specific T cell response</p> <p>Looking for human tumor models? Please visit <a href="https://www.reactionbiology.com/services/in-vivo-pharmacology/xenograft-tumor-models">Xenograft Models</a> for more information.</p> </div> </div></div><div class="paragraph text-top-center images-0 no-margin-bottom headline-center contact-buttons- paragraph--type--text-with-image paragraph--view-mode--default"><div class="center container"><div class="text-wrapper"><h2>Options for Tumor Placement</h2><div class="text-mit-bild-text"></div></div></div></div><div id="smm-id2" class="paragraph paragraph--type--teaser-boxes paragraph--view-mode--default"><div class="container center"><div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-above field__items"><div class="paragraph paragraph--type--teaser violet paragraph--view-mode--default"> <a href="/services/in-vivo-pharmacology/subcutaneous-tumor-models/"> <div class="field field--name-field-icon field--type-image field--label-hidden field__items">  <svg 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class="field__item">Subcutaneous Tumor Models</h3> <div class="field field--name-field-text-plain field--type-string-long field--label-hidden field__items"> Efficient models for first-in-animal studies. </div> </a> </div><div class="paragraph paragraph--type--teaser violet paragraph--view-mode--default"> <a href="/services/in-vivo-pharmacology/subqperior-tumor-models/"> <div class="field field--name-field-icon field--type-image field--label-hidden field__items">  <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" id="Ebene_1" x="0px" y="0px" viewBox="0 0 146.7 126.2" xml:space="preserve"> <path class="st0" d="M71,82.2c3.1-0.5,5.9-0.9,8.6-1.4c0.3-0.1,0.7-0.6,0.7-0.9c0.4-3.2,0.7-6.5,2.4-9.3c1.8-3,4.3-5,7.9-5.3 c4.3-0.3,7.8,1.1,9.9,5c1,1.8,1.5,3.9,2.2,5.9c3.3,0.3,6.9,0.6,10.5,0.8c0.7-2.6,1.7-5,3.7-7c4.6-4.5,12.6-3.4,15.8,2.1 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d="M103.3,1.3c0.6,0.7,1,1.1,1.3,1.5c-0.5,0.4-0.9,0.9-1.4,1.1c-0.6,0.2-1.3-0.2-1.1-1 C102.3,2.4,102.8,2,103.3,1.3z"></path> <path class="st0" d="M78.1,22c-0.7,0.5-1.1,1-1.4,1c-0.7-0.1-1.6-0.3-1.4-1.3c0.1-0.4,0.8-1,1-1C76.9,20.8,77.3,21.3,78.1,22z"></path> <path class="st0" d="M104.4,12.4c-0.1,0.1-0.4,0.7-0.8,0.7c-0.7,0.2-1.4-0.8-1.3-1.8c0.1-0.3,0.5-0.9,0.8-0.9 C104.1,10.5,104.5,11.2,104.4,12.4z"></path> <path class="st0" d="M88.8,5.4c0.3,0.4,1,0.7,1,1.1c0,0.9-0.8,1.2-1.6,1.2c-0.4,0-1.1-0.6-1.1-0.9C87.1,5.9,87.7,5.5,88.8,5.4z"></path> <path class="st0" d="M87.1,14.2c0.4,0.7,0.8,1,0.8,1.2c0,0.9-0.6,1.4-1.5,1.3c-0.3,0-0.8-0.7-0.8-0.8C86,15.4,86.4,15,87.1,14.2z"></path> </svg> </div> <h3 class="field__item">SubQperior™ Tumor Models</h3> <div class="field field--name-field-text-plain field--type-string-long field--label-hidden field__items"> An innovative alternative to subcutaneous models. </div> </a> </div><div class="paragraph paragraph--type--teaser violet paragraph--view-mode--default"> 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C76.9,77.4,76.4,77.1,75.7,76.5z"></path> </svg> </div> <h3 class="field__item">Orthotopic Tumor Models</h3> <div class="field field--name-field-text-plain field--type-string-long field--label-hidden field__items"> Tumors grown in their original tumor environment for more meaningful study results. </div> </a> </div><div class="paragraph paragraph--type--teaser violet paragraph--view-mode--default"> <a href="/services/in-vivo-pharmacology/metastasis-models/"> <div class="field field--name-field-icon field--type-image field--label-hidden field__items">  <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" id="Ebene_1" x="0px" y="0px" viewBox="0 0 113.3 99.4" xml:space="preserve"> <path d="M52.1,72.4c0,3.9-0.1,7.8-1.6,11.5c-2.7,6.9-7.5,11.4-15,12.6c-2.1,0.3-4.3,0.4-6.5,0.5c-5.6,0.3-11.2,0.8-16.8,1.8 c-1.9,0.4-3.9,0.6-5.8,0.6c-2.6-0.1-4.1-1.9-4.8-4.1c-0.7-2.1-1-4.4-1.2-6.6C0,86.8,0,84.9,0,83.1C0.2,75.9,1.2,68.9,2.7,62 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d="M96.3,76.8c-0.5,0.4-0.7,0.7-1,0.8c-0.2,0-0.5-0.3-0.8-0.5c0.3-0.3,0.6-0.6,0.9-0.8C95.5,76.2,95.9,76.5,96.3,76.8z"></path> </svg> </div> <h3 class="field__item">Metastasis Models</h3> <div class="field field--name-field-text-plain field--type-string-long field--label-hidden field__items"> Models for tackling the mean streak of cancer: metastasis. </div> </a> </div><div class="paragraph paragraph--type--teaser violet paragraph--view-mode--default"> <a href="/services/in-vivo-pharmacology/immuno-oncology-tumor-models/mouse-derived-isograft-tumor-models-mdi/"> <div class="field field--name-field-icon field--type-image field--label-hidden field__items">  <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" id="Ebene_1" x="0px" y="0px" viewBox="0 0 150 135" xml:space="preserve"> <path d="M58.8,60.4c-3.5,0-6.9,0-10.3,0c-1.3,0-2.5-0.3-3.8-0.4c-0.8-0.1-1.3-0.1-1.5,0.9c-1,3.6-2.8,6.6-6.2,8.3 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c0,0.3,0.2,0.7,0.4,0.9c0.1,0.1,0.6,0,0.8-0.2C76.7,89.7,77.1,89.2,77.8,88.6z"></path> <path d="M28,57.2c0.2-4.3,1.2-8.2,2.8-11.9c2.1-4.8,5.3-8.7,8.7-12.6c4.1-4.6,8.9-8.5,14-11.8c0.3-0.2,0.7-0.5,1-0.6 c0.5-0.2,1-0.5,1.5,0.1c0.4,0.7,0.1,1.1-0.4,1.5c-1.2,1-2.4,1.9-3.6,2.9c-5.1,4.4-9.2,9.6-12.3,15.7c-1.4,2.9-1.9,6-2.2,9.2 c-0.3,3.4,0,6.9-1.2,10.2c-1,2.9-2.9,4-5.5,3.1c-1.6-0.6-2.2-1.9-2.5-3.3C28.1,58.8,28.1,57.8,28,57.2z"></path> <path d="M137.1,30.3c0.7,1,1.4,1.7,1.8,2.6c0.2,0.3-0.2,1-0.5,1.4c-1.5,2.5-3.2,4.8-4.6,7.4c-1.5,2.8-2.1,5.9-2.4,9.1 c-0.3,3.5-0.8,6.9-1.2,10.4c0,0.3-0.2,0.7-0.3,1c-0.9,2-2.3,2.8-4.3,2.6c-1.7-0.2-3-1.7-3.4-3.7c-0.8-4.3,0.3-8.4,1.7-12.3 c1.9-5.3,5.1-9.7,8.8-13.7C134.2,33.4,135.6,31.9,137.1,30.3z"></path> <path d="M75.1,69.4c-0.3-0.5-0.6-0.9-0.5-1.1c0.1-0.3,0.5-0.7,0.8-0.7c0.2,0,0.8,0.5,0.8,0.6C75.9,68.6,75.5,68.9,75.1,69.4z"></path> <path d="M66.2,96.8c0.4-0.4,0.7-0.9,1.1-1.3c0.1,0.1,0.3,0.1,0.4,0.2c-0.1,0.7-0.3,1.5-0.4,2.2c0,0.1-0.6,0.1-0.6,0 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