Search results for: CDKAL1

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CDKAL1</title> <meta name="description" content="Search results for: CDKAL1"> <meta name="keywords" content="CDKAL1"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="CDKAL1"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: CDKAL1</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> The Phylogenetic Investigation of Candidate Genes Related to Type II Diabetes in Man and Other Species</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Srijoni%20Banerjee">Srijoni Banerjee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sequences of some of the candidate genes (e.g., CPE, CDKAL1, GCKR, HSD11B1, IGF2BP2, IRS1, LPIN1, PKLR, TNF, PPARG) implicated in some of the complex disease, e.g. Type II diabetes in man has been compared with other species to investigate phylogenetic affinity. Based on mRNA sequence of these genes of 7 to 8 species, using bioinformatics tools Mega 5, Bioedit, Clustal W, distance matrix was obtained. Phylogenetic trees were obtained by NJ and UPGMA clustering methods. The results of the phylogenetic analyses show that of the species compared: Xenopus l., Danio r., Macaca m., Homo sapiens s., Rattus n., Mus m. and Gallus g., Bos taurus, both NJ and UPGMA clustering show close affinity between clustering of Homo sapiens s. (Man) with Rattus n. (Rat), Mus m. species for the candidate genes, except in case of Lipin1 gene. The results support the functional similarity of these genes in physiological and biochemical process involving man and mouse/rat. Therefore, in understanding the complex etiology and treatment of the complex disease mouse/rate model is the best laboratory choice for experimentation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=phylogeny" title="phylogeny">phylogeny</a>, <a href="https://publications.waset.org/abstracts/search?q=candidate%20gene%20of%20type-2%20diabetes" title=" candidate gene of type-2 diabetes"> candidate gene of type-2 diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=CPE" title=" CPE"> CPE</a>, <a href="https://publications.waset.org/abstracts/search?q=CDKAL1" title=" CDKAL1"> CDKAL1</a>, <a href="https://publications.waset.org/abstracts/search?q=GCKR" title=" GCKR"> GCKR</a>, <a href="https://publications.waset.org/abstracts/search?q=HSD11B1" title=" HSD11B1"> HSD11B1</a>, <a href="https://publications.waset.org/abstracts/search?q=IGF2BP2" title=" IGF2BP2"> IGF2BP2</a>, <a href="https://publications.waset.org/abstracts/search?q=IRS1" title=" IRS1"> IRS1</a>, <a href="https://publications.waset.org/abstracts/search?q=LPIN1" title=" LPIN1"> LPIN1</a>, <a href="https://publications.waset.org/abstracts/search?q=PKLR" title=" PKLR"> PKLR</a>, <a href="https://publications.waset.org/abstracts/search?q=TNF" title=" TNF"> TNF</a>, <a href="https://publications.waset.org/abstracts/search?q=PPARG" title=" PPARG"> PPARG</a> </p> <a href="https://publications.waset.org/abstracts/5222/the-phylogenetic-investigation-of-candidate-genes-related-to-type-ii-diabetes-in-man-and-other-species" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/5222.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">321</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> 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Search results for: CDKAL1