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<!DOCTYPE html><html data-wf-domain="www.manifold.bio" data-wf-page="66189cfe8d5ce0ad1a203bfc" data-wf-site="66189cfe8d5ce0ad1a203b6e" lang="en"><head><meta charset="utf-8"/><title>Manifold Bio • High Throughput In Vivo Drug Design</title><meta content="Our innovative technology combines protein barcoding and high-throughput in vivo capabilities to design drugs with more precise molecular testing." name="description"/><meta content="Manifold Bio • High Throughput In Vivo Drug Design" property="og:title"/><meta content="Our innovative technology combines protein barcoding and high-throughput in vivo capabilities to design drugs with more precise molecular testing." property="og:description"/><meta content="Manifold Bio • High Throughput In Vivo Drug Design" property="twitter:title"/><meta content="Our innovative technology combines protein barcoding and high-throughput in vivo capabilities to design drugs with more precise molecular testing." property="twitter:description"/><meta property="og:type" content="website"/><meta content="summary_large_image" name="twitter:card"/><meta content="width=device-width, initial-scale=1" name="viewport"/><link href="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/css/manifold-bio-staging.webflow.8b0a05f21.css" rel="stylesheet" type="text/css"/><link href="https://fonts.googleapis.com" rel="preconnect"/><link href="https://fonts.gstatic.com" rel="preconnect" crossorigin="anonymous"/><script src="https://ajax.googleapis.com/ajax/libs/webfont/1.6.26/webfont.js" type="text/javascript"></script><script type="text/javascript">WebFont.load({ google: { families: ["DM Sans:300,regular,500,600,700"] }});</script><script type="text/javascript">!function(o,c){var n=c.documentElement,t=" w-mod-";n.className+=t+"js",("ontouchstart"in o||o.DocumentTouch&&c instanceof DocumentTouch)&&(n.className+=t+"touch")}(window,document);</script><link href="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66330b2a3de1ecb43805eec8_6463a2b3aca734e665ad68f7_favicon-32x32.png" rel="shortcut icon" type="image/x-icon"/><link href="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66330b33727762a80414b962_6463a2b3aca734e665ad684b_mstile-310x310.png" rel="apple-touch-icon"/> <style> * { -webkit-font-smoothing: antialiased; -moz-osx-font-smoothing: grayscale; -o-font-smoothing: antialiased; } </style> </head><body><div class="page-wrapper"><div class="global-styles w-embed"><style> /* Set color style to inherit */ .inherit-color * { color: inherit; } /* Focus state style for keyboard navigation for the focusable elements */ *[tabindex]:focus-visible, input[type="file"]:focus-visible { outline: 0.125rem solid #4d65ff; outline-offset: 0.125rem; } /* Get rid of top margin on first element in any rich text element */ .w-richtext > :not(div):first-child, .w-richtext > div:first-child > :first-child { margin-top: 0 !important; } /* Get rid of bottom margin on last element in any rich text element */ .w-richtext>:last-child, .w-richtext ol li:last-child, .w-richtext ul li:last-child { margin-bottom: 0 !important; } /* Prevent all click and hover interaction with an element */ .pointer-events-off { pointer-events: none; } /* Enables all click and hover interaction with an element */ .pointer-events-on { pointer-events: auto; } /* Create a class of .div-square which maintains a 1:1 dimension of a div */ .div-square::after { content: ""; display: block; padding-bottom: 100%; } /* Make sure containers never lose their center alignment */ .container-medium,.container-small, .container-large { margin-right: auto !important; margin-left: auto !important; } /* Make the following elements inherit typography styles from the parent and not have hardcoded values. 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id="w-node-_89961a8d-5cf3-d92f-eea6-5b782cdcb6d1-2cdcb6cf" class="home-hero_navbar-logo-wrapper"><a id="w-node-_89961a8d-5cf3-d92f-eea6-5b782cdcb6d2-2cdcb6cf" href="/" aria-current="page" class="home-hero_navbar-logo-link w-inline-block w--current"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/663307242d4a493de2be71e7_manifoldbio_logo_close_crop.svg" loading="eager" id="w-node-_89961a8d-5cf3-d92f-eea6-5b782cdcb6d3-2cdcb6cf" alt="Manifold Bio logo" class="home-hero_navbar-logo"/></a></div></div></div><div class="padding-top"><div class="w-layout-grid home-hero_content-layout"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76f81-1a203bfc" class="home-hero_image-wrapper"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66565add47813b7a4e830367_hero_human.webp" loading="eager" width="1098" sizes="(max-width: 479px) 100vw, (max-width: 767px) 80vw, 50vw" alt="Stylized illustration of a human head and torso" srcset="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66565add47813b7a4e830367_hero_human-p-500.webp 500w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66565add47813b7a4e830367_hero_human-p-800.webp 800w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66565add47813b7a4e830367_hero_human.webp 1005w" class="home-hero_image"/></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76f83-1a203bfc" class="home-hero_text-pane"><div class="padding-vertical padding-xxhuge"><div class="home-hero_title-wrapper"><div class="margin-bottom margin-medium"><div class="text-color-black"><div class="icon-1x1-medium w-embed"><svg aria-hidden="true" role="img" width="100%" height="100%" viewBox="0 0 60 51" fill="currentColor" xmlns="http://www.w3.org/2000/svg"> <path d="M14.194 1.25941L13.8201 1.59135L14.194 1.25941C13.9422 0.975713 13.5182 0.924747 13.2063 1.14068L9.75097 3.53282C9.38006 3.7896 9.31814 4.31336 9.61895 4.64956L21.9556 18.4376V48.8099C21.9556 49.2241 22.2914 49.5599 22.7056 49.5599H26.3736C26.7878 49.5599 27.1236 49.2241 27.1236 48.8099V16.1087C27.1236 15.9252 27.0563 15.748 26.9344 15.6108L14.194 1.25941ZM22.0193 18.5087C22.0191 18.5086 22.0189 18.5084 22.0188 18.5082L22.0193 18.5087L22.2056 18.342L22.0193 18.5087Z" fill="currentColor" stroke="currentColor"/> <rect x="1.05314" y="11.5408" width="5.64855" height="16.3393" rx="0.75" transform="rotate(-41.3176 1.05314 11.5408)" fill="currentColor" stroke="currentColor"/> <path d="M45.8416 1.25941L46.2155 1.59135L45.8416 1.25941C46.0935 0.975713 46.5175 0.924747 46.8294 1.14068L50.2847 3.53282C50.6556 3.7896 50.7175 4.31336 50.4167 4.64956L38.0801 18.4376V48.8099C38.0801 49.2241 37.7443 49.5599 37.3301 49.5599H33.6621C33.2479 49.5599 32.9121 49.2241 32.9121 48.8099V16.1087C32.9121 15.9252 32.9794 15.748 33.1012 15.6108L45.8416 1.25941ZM38.0164 18.5087C38.0165 18.5086 38.0167 18.5084 38.0169 18.5082L38.0164 18.5087L37.8301 18.342L38.0164 18.5087Z" fill="currentColor" stroke="currentColor"/> <rect x="0.705647" y="-0.0454141" width="5.64855" height="16.3393" rx="0.75" transform="matrix(-0.751061 -0.660233 -0.660233 0.751061 59.4825 12.0408)" fill="currentColor" stroke="currentColor"/> </svg></div></div></div><div class="margin-bottom margin-xlarge"><h1 class="heading-style-h1 text-color-black">Tissue Targeted Medicines, Designed In Vivo.</h1></div></div><div class="home-hero_lead-wrapper margin-bottom margin-large"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76f8d-1a203bfc" class="home-hero_link-wrapper"><a href="#platform" class="home-hero_link">Platform</a><a href="#pipeline" class="home-hero_link">Pipeline</a><a href="#partnering" class="home-hero_link">Partnering</a><a href="#team" class="home-hero_link">Team</a></div><p id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76f96-1a203bfc" class="text-size-medium">Manifold is using in vivo biologics design to unlock a new era of tissue-targeted medicines.<br/><br/>Our mDesign platform combines an industry-first 100-plex pooled in vivo screening technology with AI-guided protein design to sculpt the biodistribution, pharmacokinetics, and other drug-like properties of protein-based therapeutics directly in living systems. <br/><br/>At Manifold, we are advancing a wave of potent, tolerable medicines for the brain and beyond, and reinventing drug discovery using mDesign.</p></div></div></div></div></div></div></div></div></header><section id="platform" class="section_platform"><div class="padding-global"><div class="container-large"><div class="padding-section-large"><div class="platform_explainer_wrapper"><div class="margin-bottom margin-xlarge"><div class="max-width-medium"><h2 class="heading-style-h2 text-color-black">mDesign: How it Works</h2></div></div><div class="platform_explainer_component"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fa8-1a203bfc" class="platform_explainer_card"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66a1978d60b3bf81796e3075_ai-guided-protein-design.png" loading="lazy" alt="" class="platform_explainer_card-image"/><div class="platform_explainer_card-text-wrapper"><h3 class="platform_explainer_card-heading">AI-Guided Protein Design</h3><p class="platform_explainer_card-text">Generative design of libraries and antibodies combined with high-throughput display</p></div><div aria-label="Right arrow" class="platform_explainer_card-arrow-wrapper"><div class="icon-embed-xsmall w-embed"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" class="iconify iconify--tabler" width="100%" height="100%" preserveAspectRatio="xMidYMid meet" viewBox="0 0 24 24"><path fill="none" stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" d="M5 12h14m-6 6l6-6m-6-6l6 6"></path></svg></div></div></div><div class="platform_explainer_card is-main"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66a197b13a874c407d91653a_magnifying-base.png" loading="lazy" sizes="(max-width: 767px) 40vw, 20vw" srcset="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66a197b13a874c407d91653a_magnifying-base-p-500.png 500w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66a197b13a874c407d91653a_magnifying-base.png 1788w" alt="Silhouette of a mouse with the label "Powered by mCodes"" class="platform_explainer_card-image is-featured"/><div class="platform_explainer_card-magnifying-component"><div class="platform_explainer_card-magnifying-image"></div><div class="platform_explainer_card-magnifying-accent w-embed"><svg width="100%" height="100%" viewBox="0 0 72 71" fill="none" xmlns="http://www.w3.org/2000/svg"> <line x1="0.9488" y1="70.5026" x2="68.9488" y2="63.5026" stroke="currentColor"/> <line x1="68.5006" y1="63.9762" x2="71.5006" y2="0.976227" stroke="currentColor"/> </svg></div></div><div class="platform_explainer_card-text-wrapper is-main"><h3 class="platform_explainer_card-heading">In Vivo Multiplexing</h3><p class="platform_explainer_card-text">Evaluate distribution of 100 protein designs simultaneously in a single animal</p></div><div aria-label="Right arrow" class="platform_explainer_card-arrow-wrapper"><div class="icon-embed-xsmall w-embed"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" class="iconify iconify--tabler" width="100%" height="100%" preserveAspectRatio="xMidYMid meet" viewBox="0 0 24 24"><path fill="none" stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" d="M5 12h14m-6 6l6-6m-6-6l6 6"></path></svg></div></div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fbd-1a203bfc" class="platform_explainer_card"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66a1980674b8789b3feb4e1d_shuttled-therapeutics.png" loading="lazy" alt="" class="platform_explainer_card-image"/><div class="platform_explainer_card-text-wrapper"><h3 class="platform_explainer_card-heading">Tissue-targeted Biologics Pipeline</h3><p class="platform_explainer_card-text">Unlocking potent, tolerable medicines</p></div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fc4-1a203bfc" class="platform_explainer_iteration-wrapper"><div class="platform_explainer_iteration-card"><div aria-label="Looping arrow icon" class="platform_explainer_iteration-card-icon-wrapper"><div class="platform_explainer_iteration-card-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" class="iconify iconify--tabler" width="100%" height="100%" preserveAspectRatio="xMidYMid meet" viewBox="0 0 24 24"><path fill="none" stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" d="M4 12V9a3 3 0 0 1 3-3h13m-3-3l3 3l-3 3m3 3v3a3 3 0 0 1-3 3H4m3 3l-3-3l3-3"></path></svg></div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fc8-1a203bfc" class="platform_explainer_iteration-card-text-wrapper"><div>AI Iteration</div></div><div aria-label="Arrow looping back to first card" class="platform_explainer_iteration-card-accent"><div aria-hidden="true" class="platform_explainer_iteration-card-accent-arrow-wrapper"><div class="icon-embed-xsmall w-embed"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" class="iconify iconify--tabler" width="100%" height="100%" preserveAspectRatio="xMidYMid meet" viewBox="0 0 24 24"><path fill="none" stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" d="m6 15l6-6l6 6"></path></svg></div></div></div></div></div></div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fce-1a203bfc" class="margin-top margin-large"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fcf-1a203bfc" class="platform_mcodes_component"><div class="platform_mcodes_image-wrapper"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66f4a21225959640b9ad509a_placeholder_coded-dna.webp" loading="lazy" sizes="(max-width: 479px) 75vw, (max-width: 767px) 45vw, 22vw" srcset="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66f4a21225959640b9ad509a_placeholder_coded-dna-p-500.webp 500w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/66f4a21225959640b9ad509a_placeholder_coded-dna.webp 680w" alt="Illustration of a DNA strand with mCode™ protein barcodes tagged to segments of it" class="platform_mcodes_image"/></div><div class="platform_mcodes_body"><div class="max-width-large"><div class="margin-bottom margin-small"><h3 class="platform_mcodes_heading">Powered by mCodes</h3></div><div class="text-rich-text w-richtext"><p>High-throughput, 100plex <em>in vivo</em> screening is made possible by mCodes: a first-of-its-kind protein barcoding and quantitation technology invented by Manifold. mCodes are specific, sensitive, inert, and quantitative - serving as unique identifiers to track and quantitate large pools of biotherapeutic drug candidates in complex living systems.</p></div></div></div></div></div></div></div></div></section><section id="pipeline" class="section_pipeline"><div class="pipeline_background-wrapper"><div class="pipeline_background"></div></div><div class="pipeline_content-wrapper"><div class="padding-global"><div class="container-large"><div class="padding-top padding-xhuge"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fe4-1a203bfc" class="margin-bottom margin-huge"><div class="icon-1x1-xsmall w-embed"><svg aria-hidden="true" role="img" width="100%" height="100%" viewBox="0 0 60 51" fill="currentColor" xmlns="http://www.w3.org/2000/svg"> <path d="M14.194 1.25941L13.8201 1.59135L14.194 1.25941C13.9422 0.975713 13.5182 0.924747 13.2063 1.14068L9.75097 3.53282C9.38006 3.7896 9.31814 4.31336 9.61895 4.64956L21.9556 18.4376V48.8099C21.9556 49.2241 22.2914 49.5599 22.7056 49.5599H26.3736C26.7878 49.5599 27.1236 49.2241 27.1236 48.8099V16.1087C27.1236 15.9252 27.0563 15.748 26.9344 15.6108L14.194 1.25941ZM22.0193 18.5087C22.0191 18.5086 22.0189 18.5084 22.0188 18.5082L22.0193 18.5087L22.2056 18.342L22.0193 18.5087Z" fill="currentColor" stroke="currentColor"/> <rect x="1.05314" y="11.5408" width="5.64855" height="16.3393" rx="0.75" transform="rotate(-41.3176 1.05314 11.5408)" fill="currentColor" stroke="currentColor"/> <path d="M45.8416 1.25941L46.2155 1.59135L45.8416 1.25941C46.0935 0.975713 46.5175 0.924747 46.8294 1.14068L50.2847 3.53282C50.6556 3.7896 50.7175 4.31336 50.4167 4.64956L38.0801 18.4376V48.8099C38.0801 49.2241 37.7443 49.5599 37.3301 49.5599H33.6621C33.2479 49.5599 32.9121 49.2241 32.9121 48.8099V16.1087C32.9121 15.9252 32.9794 15.748 33.1012 15.6108L45.8416 1.25941ZM38.0164 18.5087C38.0165 18.5086 38.0167 18.5084 38.0169 18.5082L38.0164 18.5087L37.8301 18.342L38.0164 18.5087Z" fill="currentColor" stroke="currentColor"/> <rect x="0.705647" y="-0.0454141" width="5.64855" height="16.3393" rx="0.75" transform="matrix(-0.751061 -0.660233 -0.660233 0.751061 59.4825 12.0408)" fill="currentColor" stroke="currentColor"/> </svg></div><div class="text-weight-semibold">Pipeline</div></div></div><div class="padding-bottom padding-xhuge"><div class="pipeline_content-inner"><div class="pipeline_content-layout"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76feb-1a203bfc" class="pipeline_heading-wrapper"><h2 id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fec-1a203bfc" class="heading-style-h2 is-light-gradient">Shuttled Therapeutics for Neuromedicine and Beyond</h2></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76fee-1a203bfc" class="pipeline_accent-image-wrapper"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6632d94bb1ad2470e6036669_brain.webp" loading="lazy" width="1210" sizes="(max-width: 767px) 60vw, (max-width: 991px) 440px, 9vw" alt="Stylized illustration of a brain" srcset="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6632d94bb1ad2470e6036669_brain-p-500.webp 500w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6632d94bb1ad2470e6036669_brain.webp 515w" class="pipeline-accent-image"/></div></div><div class="margin-top margin-large"><div class="pipeline_content-layout"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76ff2-1a203bfc" class="text-rich-text w-richtext"><p>A renaissance has begun in neuroscience with recent clinical data supporting a number of promising targets for therapeutic intervention.</p><p>Yet, delivery of diverse modalities across the blood-brain barrier and to specific regions of the brain remains a challenge that limits efficacy and creates burdens on routes of administration.</p><p>Manifold has moved quickly using in vivo design to establish a brain shuttling platform and is now building a pipeline of medicines for neurological disorders with immense unmet need.</p></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76ff9-1a203bfc" class="pipeline_diagram"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a76ffa-1a203bfc" class="pipeline_diagram_header"><div class="pipeline_diagram_header-cell is-with-right-border is-first-on-desktop hide-mobile-portrait"><div>Indication</div></div><div class="pipeline_diagram_header-cell is-with-right-border is-first-on-mobile"><div>In Vivo <br/>Discovery</div></div><div class="pipeline_diagram_header-cell is-with-right-border"><div>In Vivo <br/>Optimization</div></div><div class="pipeline_diagram_header-cell"><div>IND-enabling</div></div></div><div class="pipeline_diagram_list-wrapper w-dyn-list"><div role="list" class="pipeline_diagram_list w-dyn-items"><div role="listitem" class="pipeline_diagram_list-item w-dyn-item"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7700e-1a203bfc" class="pipeline_diagram_list-item-cell"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7700f-1a203bfc" class="text-size-small">Alzheimer's Disease</div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77010-1a203bfc" class="pipeline_list-item-progress w-embed"><style> .pipeline-progress-custom-embed { background-color: #D7E0E7; } /* Mobile portrait and smaller devices */ /*@media screen and (max-width: 479px) { .pipeline-progress-custom-embed { background-color: var(--background-color--background-primary); } }*/ </style> <div class="pipeline-progress-custom-embed" style="display: flex; align-items: center; height: 2.25rem; width: 60%; color: var(--base-color-brand--black); padding: 0.125rem 0.35rem; border-radius: 0.25rem;"><span>Shuttled Antibody</span></div></div></div><div role="listitem" class="pipeline_diagram_list-item w-dyn-item"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7700e-1a203bfc" class="pipeline_diagram_list-item-cell"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7700f-1a203bfc" class="text-size-small">Parkinson's Disease / MSA</div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77010-1a203bfc" class="pipeline_list-item-progress w-embed"><style> .pipeline-progress-custom-embed { background-color: #D7E0E7; } /* Mobile portrait and smaller devices */ /*@media screen and (max-width: 479px) { .pipeline-progress-custom-embed { background-color: var(--background-color--background-primary); } }*/ </style> <div class="pipeline-progress-custom-embed" style="display: flex; align-items: center; height: 2.25rem; width: 50%; color: var(--base-color-brand--black); padding: 0.125rem 0.35rem; border-radius: 0.25rem;"><span>Shuttled Antibody</span></div></div></div><div role="listitem" class="pipeline_diagram_list-item w-dyn-item"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7700e-1a203bfc" class="pipeline_diagram_list-item-cell"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7700f-1a203bfc" class="text-size-small">Multiple Sclerosis</div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77010-1a203bfc" class="pipeline_list-item-progress w-embed"><style> .pipeline-progress-custom-embed { background-color: #D7E0E7; } /* Mobile portrait and smaller devices */ /*@media screen and (max-width: 479px) { .pipeline-progress-custom-embed { background-color: var(--background-color--background-primary); } }*/ </style> <div class="pipeline-progress-custom-embed" style="display: flex; align-items: center; height: 2.25rem; width: 40%; color: var(--base-color-brand--black); padding: 0.125rem 0.35rem; border-radius: 0.25rem;"><span>Shuttled Antibody</span></div></div></div><div role="listitem" class="pipeline_diagram_list-item w-dyn-item"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7700e-1a203bfc" class="pipeline_diagram_list-item-cell"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7700f-1a203bfc" class="text-size-small">(Multiple follow-ons)</div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77010-1a203bfc" class="pipeline_list-item-progress w-embed"><style> .pipeline-progress-custom-embed { background-color: #D7E0E7; } /* Mobile portrait and smaller devices */ /*@media screen and (max-width: 479px) { .pipeline-progress-custom-embed { background-color: var(--background-color--background-primary); } }*/ </style> <div class="pipeline-progress-custom-embed" style="display: flex; align-items: center; height: 2.25rem; width: 40%; color: var(--base-color-brand--black); padding: 0.125rem 0.35rem; border-radius: 0.25rem;"><span>Shuttled Antibody</span></div></div></div></div></div></div></div></div></div></div></div></div></div></section><section id="shuttles" class="section_shuttles"><div class="padding-global"><div class="container-large"><div class="padding-section-large"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77018-1a203bfc" class="max-width-medium"><div class="margin-bottom margin-small"><h2 class="heading-style-h2 text-color-black">Expanding Shuttle Portfolio</h2></div></div><div class="text-rich-text text-size-medium columnar-text w-richtext"><p>Our pipeline is built on top of our growing portfolio of tissue-specific shuttles. These engineered protein delivery vehicles allow us to deliver a wide range of therapeutic payloads to targeted tissues with high specificity and efficiency.</p><p>Our current library includes:</p><ul role="list"><li>Brain shuttles optimized for crossing the blood-brain barrier</li><li>Emerging shuttles for other tissue types, expanding our therapeutic reach</li></ul></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77026-1a203bfc" class="margin-top margin-large"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77027-1a203bfc" class="diagram_wrapper"><div class="diagram_caption"><div class="text-size-small text-weight-medium">fig 1. Manifold shuttle portfolio</div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7702b-1a203bfc" class="mdesign_diagram-image-layout"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd172b6a0979c81fd5ac_shuttle_portfolio.webp" loading="eager" id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7702c-1a203bfc" sizes="(max-width: 767px) 90vw, 45vw" alt="Diagram showing Manifold's shuttle portfolio with diverse phenotypes" srcset="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd172b6a0979c81fd5ac_shuttle_portfolio-p-500.webp 500w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd172b6a0979c81fd5ac_shuttle_portfolio-p-800.webp 800w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd172b6a0979c81fd5ac_shuttle_portfolio-p-1080.webp 1080w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd172b6a0979c81fd5ac_shuttle_portfolio.webp 1250w" class="mdesign_diagram-image"/><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd17d3b18c554d085bf5_shuttled_therapeutics.webp" loading="eager" id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7702d-1a203bfc" sizes="(max-width: 767px) 90vw, 45vw" alt="Diagram showing optimal shuttled therapeutics" srcset="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd17d3b18c554d085bf5_shuttled_therapeutics-p-500.webp 500w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd17d3b18c554d085bf5_shuttled_therapeutics-p-800.webp 800w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd17d3b18c554d085bf5_shuttled_therapeutics-p-1080.webp 1080w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/6719bd17d3b18c554d085bf5_shuttled_therapeutics.webp 1250w" class="mdesign_diagram-image"/></div></div></div></div></div></div></section><section id="therapeutic-potential" class="section_therapeutic-potential"><div class="padding-global"><div class="container-large"><div class="padding-section-large"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77032-1a203bfc" class="max-width-medium"><div class="margin-bottom margin-xlarge"><h2 class="heading-style-h2 text-color-black">Broad Therapeutic Potential of mDesign</h2></div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77036-1a203bfc" class="therapeutic-potential_layout"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77037-1a203bfc" class="therapeutic-potential_diagram-wrapper"><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c77563d0efc68941148dc_multiplexing_mouse.webp" loading="eager" sizes="(max-width: 767px) 54vw, (max-width: 991px) 27vw, 263.5546875px" srcset="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c77563d0efc68941148dc_multiplexing_mouse-p-500.webp 500w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c77563d0efc68941148dc_multiplexing_mouse-p-800.webp 800w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c77563d0efc68941148dc_multiplexing_mouse.webp 990w" alt="In vivo multiplexing powered by mCodes™ " class="therapeutic-potential_diagram-multiplexing-image"/><img src="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c776eb78fbacdc45af501_primate.webp" loading="eager" sizes="(max-width: 479px) 64.7890625px, 107.984375px" srcset="https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c776eb78fbacdc45af501_primate-p-500.webp 500w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c776eb78fbacdc45af501_primate-p-800.webp 800w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c776eb78fbacdc45af501_primate-p-1080.webp 1080w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c776eb78fbacdc45af501_primate-p-1600.webp 1600w, https://cdn.prod.website-files.com/66189cfe8d5ce0ad1a203b6e/670c776eb78fbacdc45af501_primate.webp 1910w" alt="Silhouette of a primate" class="therapeutic-potential_diagram-primate-image"/></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7703a-1a203bfc" class="max-width-medium"><div class="margin-bottom margin-xsmall"><h3 class="heading-style-h4">Enhanced therapeutic delivery</h3></div><div class="text-rich-text text-size-medium w-richtext"><ul role="list"><li>Shuttles for brain and peripheral targets</li><li>Conditionally-activated biologics </li><li>Half-life extension</li><li>Subcutaneous administration </li><li>Improved translation of in vivo-encoded biologics</li></ul></div></div></div></div></div></div></section><section id="partnering" class="section_partnership-opps"><div class="padding-global"><div class="container-large"><div class="padding-section-large"><div class="partnership-opps_component"><div class="partnership-opps_content"><div class="max-width-large"><div class="margin-bottom margin-xsmall"><h2 class="heading-style-h2 text-color-black">Partnership Opportunities</h2></div><p class="text-size-medium">We're open to collaborations that leverage our mDesign™ platform and shuttle library to develop novel targeted therapies. Whether you're interested in neuroscience or other therapeutic areas, we offer flexible partnership models to accelerate your drug discovery efforts.</p></div></div><div class="partnership-opps_button-row"><a href="mailto:bd@manifold.bio" class="button is-gradient w-button">Contact team</a></div></div></div></div></div></section><section id="team" class="section_team"><div class="padding-global"><div class="container-large"><div class="padding-section-large"><div class="w-layout-grid team_component"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7705e-1a203bfc" class="team_heading"><div class="margin-bottom margin-small"><h2 class="heading-style-h2 text-color-black">Our Team</h2></div><p class="text-size-medium">With deep expertise spanning high-throughput molecular biology, ML-guided protein engineering and drug discovery we're united by a common mission: to create life-changing medicines by unlocking in vivo drug design at scale.</p><div class="margin-top margin-medium"><a href="https://archive.manifold.bio/careers" target="_blank" class="button is-secondary w-button">Open positions</a></div></div><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a7706a-1a203bfc" class="team_content"><div class="team_content-team"><div class="margin-bottom margin-medium"><h3 class="heading-style-h4 text-color-black">Founders & Leadership</h3></div><div class="team_list-wrapper w-dyn-list"><div role="list" class="team_list w-dyn-items"><div role="listitem" class="team_item w-dyn-item"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77072-1a203bfc" class="team_text-wrapper"><div class="text-size-large text-weight-semibold">Gleb Kuznetsov, PhD</div><header class="team_title-wrapper"><div class="text-block">Co-Founder & CEO</div><div class="team_social"><a aria-label="Google Scholar" href="https://scholar.google.com/citations?user=TJHq6loAAAAJ&hl=en" target="_blank" class="social-link w-inline-block"><div class="social-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" class="iconify iconify--ic" width="100%" height="100%" preserveAspectRatio="xMidYMid meet" viewBox="0 0 24 24"><path fill="currentColor" d="M5 13.18v2.81c0 .73.4 1.41 1.04 1.76l5 2.73c.6.33 1.32.33 1.92 0l5-2.73c.64-.35 1.04-1.03 1.04-1.76v-2.81l-6.04 3.3c-.6.33-1.32.33-1.92 0zm6.04-9.66l-8.43 4.6c-.69.38-.69 1.38 0 1.76l8.43 4.6c.6.33 1.32.33 1.92 0L21 10.09V16c0 .55.45 1 1 1s1-.45 1-1V9.59c0-.37-.2-.7-.52-.88l-9.52-5.19a2.04 2.04 0 0 0-1.92 0"></path></svg></div></a><a aria-label="LinkedIn" href="https://www.linkedin.com/in/gleb-kuznetsov/" target="_blank" class="social-link w-inline-block"><div class="social-icon w-embed"><svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" aria-hidden="true"> <path fill-rule="evenodd" clip-rule="evenodd" d="M5 3H19C20.1046 3 21 3.89543 21 5V19C21 20.1046 20.1046 21 19 21H5C3.89543 21 3 20.1046 3 19V5C3 3.89543 3.89543 3 5 3ZM8 18C8.27614 18 8.5 17.7761 8.5 17.5V10.5C8.5 10.2239 8.27614 10 8 10H6.5C6.22386 10 6 10.2239 6 10.5V17.5C6 17.7761 6.22386 18 6.5 18H8ZM7.25 9C6.42157 9 5.75 8.32843 5.75 7.5C5.75 6.67157 6.42157 6 7.25 6C8.07843 6 8.75 6.67157 8.75 7.5C8.75 8.32843 8.07843 9 7.25 9ZM17.5 18C17.7761 18 18 17.7761 18 17.5V12.9C18.0325 11.3108 16.8576 9.95452 15.28 9.76C14.177 9.65925 13.1083 10.1744 12.5 11.1V10.5C12.5 10.2239 12.2761 10 12 10H10.5C10.2239 10 10 10.2239 10 10.5V17.5C10 17.7761 10.2239 18 10.5 18H12C12.2761 18 12.5 17.7761 12.5 17.5V13.75C12.5 12.9216 13.1716 12.25 14 12.25C14.8284 12.25 15.5 12.9216 15.5 13.75V17.5C15.5 17.7761 15.7239 18 16 18H17.5Z" fill="CurrentColor"/> </svg></div></a></div></header></div><div class="team_image-wrapper"><img src="https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/662aeb8c4bcac9595189802f_Gleb%20Kuznetsov.svg" loading="lazy" alt="Gleb Kuznetsov, PhD" class="team_image"/></div></div><div role="listitem" class="team_item w-dyn-item"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77072-1a203bfc" class="team_text-wrapper"><div class="text-size-large text-weight-semibold">Pierce Ogden, PhD</div><header class="team_title-wrapper"><div class="text-block">Co-Founder & CSO</div><div class="team_social"><a aria-label="Google Scholar" href="https://scholar.google.com/citations?user=UEcLTHsAAAAJ&hl=en" target="_blank" class="social-link w-inline-block"><div class="social-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" class="iconify iconify--ic" width="100%" height="100%" preserveAspectRatio="xMidYMid meet" viewBox="0 0 24 24"><path fill="currentColor" d="M5 13.18v2.81c0 .73.4 1.41 1.04 1.76l5 2.73c.6.33 1.32.33 1.92 0l5-2.73c.64-.35 1.04-1.03 1.04-1.76v-2.81l-6.04 3.3c-.6.33-1.32.33-1.92 0zm6.04-9.66l-8.43 4.6c-.69.38-.69 1.38 0 1.76l8.43 4.6c.6.33 1.32.33 1.92 0L21 10.09V16c0 .55.45 1 1 1s1-.45 1-1V9.59c0-.37-.2-.7-.52-.88l-9.52-5.19a2.04 2.04 0 0 0-1.92 0"></path></svg></div></a><a aria-label="LinkedIn" href="https://www.linkedin.com/in/pierce-ogden-470b3836/" target="_blank" class="social-link w-inline-block"><div class="social-icon w-embed"><svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" aria-hidden="true"> <path fill-rule="evenodd" clip-rule="evenodd" d="M5 3H19C20.1046 3 21 3.89543 21 5V19C21 20.1046 20.1046 21 19 21H5C3.89543 21 3 20.1046 3 19V5C3 3.89543 3.89543 3 5 3ZM8 18C8.27614 18 8.5 17.7761 8.5 17.5V10.5C8.5 10.2239 8.27614 10 8 10H6.5C6.22386 10 6 10.2239 6 10.5V17.5C6 17.7761 6.22386 18 6.5 18H8ZM7.25 9C6.42157 9 5.75 8.32843 5.75 7.5C5.75 6.67157 6.42157 6 7.25 6C8.07843 6 8.75 6.67157 8.75 7.5C8.75 8.32843 8.07843 9 7.25 9ZM17.5 18C17.7761 18 18 17.7761 18 17.5V12.9C18.0325 11.3108 16.8576 9.95452 15.28 9.76C14.177 9.65925 13.1083 10.1744 12.5 11.1V10.5C12.5 10.2239 12.2761 10 12 10H10.5C10.2239 10 10 10.2239 10 10.5V17.5C10 17.7761 10.2239 18 10.5 18H12C12.2761 18 12.5 17.7761 12.5 17.5V13.75C12.5 12.9216 13.1716 12.25 14 12.25C14.8284 12.25 15.5 12.9216 15.5 13.75V17.5C15.5 17.7761 15.7239 18 16 18H17.5Z" fill="CurrentColor"/> </svg></div></a></div></header></div><div class="team_image-wrapper"><img src="https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/6634089ee053f990ab4209ab_Pierce%20Ogden.webp" loading="lazy" alt="Pierce Ogden, PhD" sizes="80px" srcset="https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/6634089ee053f990ab4209ab_Pierce%20Ogden-p-500.webp 500w, https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/6634089ee053f990ab4209ab_Pierce%20Ogden-p-800.webp 800w, https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/6634089ee053f990ab4209ab_Pierce%20Ogden.webp 1112w" class="team_image"/></div></div><div role="listitem" class="team_item w-dyn-item"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77072-1a203bfc" class="team_text-wrapper"><div class="text-size-large text-weight-semibold">Shane Lofgren</div><header class="team_title-wrapper"><div class="text-block">Co-Founder & Head of Portfolio Development and Strategy</div><div class="team_social"><a aria-label="Google Scholar" href="https://scholar.google.com/citations?user=sXR8LjcAAAAJ&hl=en" target="_blank" class="social-link w-inline-block"><div class="social-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" class="iconify iconify--ic" width="100%" height="100%" preserveAspectRatio="xMidYMid meet" viewBox="0 0 24 24"><path fill="currentColor" d="M5 13.18v2.81c0 .73.4 1.41 1.04 1.76l5 2.73c.6.33 1.32.33 1.92 0l5-2.73c.64-.35 1.04-1.03 1.04-1.76v-2.81l-6.04 3.3c-.6.33-1.32.33-1.92 0zm6.04-9.66l-8.43 4.6c-.69.38-.69 1.38 0 1.76l8.43 4.6c.6.33 1.32.33 1.92 0L21 10.09V16c0 .55.45 1 1 1s1-.45 1-1V9.59c0-.37-.2-.7-.52-.88l-9.52-5.19a2.04 2.04 0 0 0-1.92 0"></path></svg></div></a><a aria-label="LinkedIn" href="https://www.linkedin.com/in/shanelofgren/" 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aria-hidden="true"> <path fill-rule="evenodd" clip-rule="evenodd" d="M5 3H19C20.1046 3 21 3.89543 21 5V19C21 20.1046 20.1046 21 19 21H5C3.89543 21 3 20.1046 3 19V5C3 3.89543 3.89543 3 5 3ZM8 18C8.27614 18 8.5 17.7761 8.5 17.5V10.5C8.5 10.2239 8.27614 10 8 10H6.5C6.22386 10 6 10.2239 6 10.5V17.5C6 17.7761 6.22386 18 6.5 18H8ZM7.25 9C6.42157 9 5.75 8.32843 5.75 7.5C5.75 6.67157 6.42157 6 7.25 6C8.07843 6 8.75 6.67157 8.75 7.5C8.75 8.32843 8.07843 9 7.25 9ZM17.5 18C17.7761 18 18 17.7761 18 17.5V12.9C18.0325 11.3108 16.8576 9.95452 15.28 9.76C14.177 9.65925 13.1083 10.1744 12.5 11.1V10.5C12.5 10.2239 12.2761 10 12 10H10.5C10.2239 10 10 10.2239 10 10.5V17.5C10 17.7761 10.2239 18 10.5 18H12C12.2761 18 12.5 17.7761 12.5 17.5V13.75C12.5 12.9216 13.1716 12.25 14 12.25C14.8284 12.25 15.5 12.9216 15.5 13.75V17.5C15.5 17.7761 15.7239 18 16 18H17.5Z" fill="CurrentColor"/> </svg></div></a></div></header></div><div class="team_image-wrapper"><img src="https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/662aebf01a2d80f0d874a79a_George%20Church.svg" loading="lazy" alt="George Church, PhD" class="team_image"/></div></div><div role="listitem" class="team_item w-dyn-item"><div id="w-node-aebcb7c9-9142-4988-bcf8-03ca80a77072-1a203bfc" class="team_text-wrapper"><div class="text-size-large text-weight-semibold">Steve Holtzman</div><header class="team_title-wrapper"><div class="text-block">Executive Chairman</div><div class="team_social"><a aria-label="Google Scholar" href="#" class="social-link w-inline-block w-condition-invisible"><div class="social-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" class="iconify iconify--ic" width="100%" height="100%" preserveAspectRatio="xMidYMid meet" viewBox="0 0 24 24"><path fill="currentColor" d="M5 13.18v2.81c0 .73.4 1.41 1.04 1.76l5 2.73c.6.33 1.32.33 1.92 0l5-2.73c.64-.35 1.04-1.03 1.04-1.76v-2.81l-6.04 3.3c-.6.33-1.32.33-1.92 0zm6.04-9.66l-8.43 4.6c-.69.38-.69 1.38 0 1.76l8.43 4.6c.6.33 1.32.33 1.92 0L21 10.09V16c0 .55.45 1 1 1s1-.45 1-1V9.59c0-.37-.2-.7-.52-.88l-9.52-5.19a2.04 2.04 0 0 0-1.92 0"></path></svg></div></a><a aria-label="LinkedIn" href="https://www.linkedin.com/in/steven-holtzman-03478311/" target="_blank" class="social-link w-inline-block"><div class="social-icon w-embed"><svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" aria-hidden="true"> <path fill-rule="evenodd" clip-rule="evenodd" d="M5 3H19C20.1046 3 21 3.89543 21 5V19C21 20.1046 20.1046 21 19 21H5C3.89543 21 3 20.1046 3 19V5C3 3.89543 3.89543 3 5 3ZM8 18C8.27614 18 8.5 17.7761 8.5 17.5V10.5C8.5 10.2239 8.27614 10 8 10H6.5C6.22386 10 6 10.2239 6 10.5V17.5C6 17.7761 6.22386 18 6.5 18H8ZM7.25 9C6.42157 9 5.75 8.32843 5.75 7.5C5.75 6.67157 6.42157 6 7.25 6C8.07843 6 8.75 6.67157 8.75 7.5C8.75 8.32843 8.07843 9 7.25 9ZM17.5 18C17.7761 18 18 17.7761 18 17.5V12.9C18.0325 11.3108 16.8576 9.95452 15.28 9.76C14.177 9.65925 13.1083 10.1744 12.5 11.1V10.5C12.5 10.2239 12.2761 10 12 10H10.5C10.2239 10 10 10.2239 10 10.5V17.5C10 17.7761 10.2239 18 10.5 18H12C12.2761 18 12.5 17.7761 12.5 17.5V13.75C12.5 12.9216 13.1716 12.25 14 12.25C14.8284 12.25 15.5 12.9216 15.5 13.75V17.5C15.5 17.7761 15.7239 18 16 18H17.5Z" fill="CurrentColor"/> </svg></div></a></div></header></div><div class="team_image-wrapper"><img src="https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/6660bb19d69f6b9382a80a4f_SteveH.webp" loading="lazy" alt="Steve Holtzman" sizes="80px" srcset="https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/6660bb19d69f6b9382a80a4f_SteveH-p-500.webp 500w, https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/6660bb19d69f6b9382a80a4f_SteveH-p-800.webp 800w, https://cdn.prod.website-files.com/662adeecccd14fc5b1c9047d/6660bb19d69f6b9382a80a4f_SteveH-p-1080.webp 1080w, 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