Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic D

<!doctype html> <html lang="pt"> <head>  <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta http-equiv="Content-Language" content="pt"> <meta name="robots" content="index, follow"> <meta name="googlebot" content="index, follow"> <meta name="google-site-verification" content="IACPFCyYP-SMiV4khyHgqu1j88X5StL99Hd2ePFTlkg" />  <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.4.1/css/bootstrap.min.css">  <link rel="stylesheet" href="https://use.typekit.net/lpc2eiw.css"> <link rel="canonical" href="https://portuguese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"> <link rel="alternate" href="https://portuguese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" hreflang="pt-BR"/> <link href="https://fonts.googleapis.com/css?family=Spectral:200,200i,300,300i,400,400i,500,500i,600,600i,700,700i,800,800i" rel="stylesheet"> <link href="https://fonts.googleapis.com/css?family=Open+Sans:300,300i,400,400i,600,600i,700,700i,800,800i|Raleway:100,100i,200,200i,300,300i,400,400i,500,500i,600,600i,700,700i,800,800i,900,900i" rel="stylesheet"> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.11.2/css/all.min.css" /> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css">   <link rel="stylesheet" href="/assets/css/jquery.mCustomScrollbar.min.css"> <link href="/assets/css/iconsmind.css" rel="stylesheet"> <link href="/assets/css/metisMenu.min.css" rel="stylesheet"> <link href="/assets/css/mm-vertical-hover.css" rel="stylesheet"> <link rel="stylesheet" href="/assets/css/coolautosuggest.css"> <link rel="stylesheet" href="/assets/css/global.css"> <link rel="stylesheet" href="/assets/css/styles-journals.css">  <link href="/assets/css/main_global.css" rel="stylesheet"> <link rel="stylesheet" href="/assets/css/styles.css"> <link rel="stylesheet" href="/assets/css/author.css">  <script async src="https://www.googletagmanager.com/gtag/js?id=UA-157582964-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-GHM2ES2CHP'); </script>  <div id="target" style="position: absolute; top: 110px;"> <div><p>GET THE APP</p></div> <a href="https://play.google.com/store/apps/details?id=com.journals.iomcworld&hl=en" target="_blank" id="getAppModel"> <div class="a_icon"> <span><i class="fa fa-android"></i></span> </div> </a>  </div>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-GH5GSYYKJG"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-GHM2ES2CHP'); </script> <title>Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic D | 110404</title> <meta name="keywords" content="Bhavana Bhatnagar, Christen Jordan, Cara Randall4, Andrew Gordon, Christinea Marino, Angela Burrie and Ashkan Emadi*, "/> <meta name="description" content="A diagnosis of synchronous cancers within the same individual poses a multitude of diagnostic and treatment-related challenges. Many of these challenges pe..110404"/> <meta name="citation_publisher" content="Conselho M茅dico Online Internacional" /> <meta name="citation_journal_title" content="Relatos de Casos de Oncologia e Câncer"> <meta name="citation_title" content="Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic Ductal Adenocarcinoma with Germline Heterozygous DDX41 and MUTYH Mutations in a Patient from Appalachia, United States"> <meta name="citation_author" content="Bhavana Bhatnagar" /> <meta name="citation_author" content="Christen Jordan" /> <meta name="citation_author" content="Cara R" /> <meta name="citation_author" content="all4" /> <meta name="citation_author" content="Andrew Gordon" /> <meta name="citation_author" content="Christinea Marino" /> <meta name="citation_author" content="Angela Burrie" /> <meta name="citation_author" content="Ashkan Emadi" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="10"> <meta name="citation_issue" content="3"> <meta name="citation_abstract" content="A diagnosis of synchronous cancers within the same individual poses a multitude of diagnostic and treatment-related challenges. Many of these challenges pertain to the vast heterogeneity in cancers and presentations, patient ineligibility for clinical trials, lack of standardized guidelines to direct management and an incomplete understanding of the molecular mechanisms that contribute to the development of these cancers. We present a case of concurrent diagnoses of Pancreatic Ductal Adenocarcinoma (PDAC) and Acute Myeloid Leukemia (AML) with a comprehensive mutational analysis of the pancreatic tumor, AML blasts, and germline DNA collected from cultured skin fibroblast samples. In addition to some commonly detected mutations (e.g. KRAS Gly12Asp in PDAC and TP53 Met237lle in AML), the genetic testing revealed the presence of DDX41 and MUTYH gene mutations in both germline DNA and tumor tissue specimens. This case underscores the importance of addressing the interplay of genetic, lifestyle and environmental factors in the development of synchronous cancers in an individual, and only by doing so, evidence-based guidelines for early detection and management may be developed."> <meta name="citation_abstract_html_url" content="https://portuguese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"> </head> <body> <header>  <div class="bg-1"> <div class="container-fluid py-1"> <div class="row justify-content-between align-items-center"> <div class="col-sm-auto"> <a href="https://portuguese.iomcworld.org/" title="IOMC"><img src="/assets/img/IOMC-logo-white.svg" alt="occrs" height="50" alt="IOMC"></a> </div> <div class="col-sm-auto"> <nav class="nav"> <a class="nav-link white"><i class="fa fa-whatsapp"></i> +32(800) 709-48 </a> <a href="mailto:oncology@oncologyinsights.org" class="nav-link white"><i class="fas fa-envelope-square"></i> oncology@oncologyinsights.org</a>  <div class="nav-item dropdown multi_lang j_multi_lang"> <a class="nav-link dropdown-toggle" href="#" id="multi_lang" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Language </a> <div class="dropdown-menu" aria-labelledby=""> <a class="dropdown-item" href="https://www.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="English"> <img src="https://www.longdom.org/admin/flags/usa.png">English </a> <a class="dropdown-item" href="https://spanish.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Spanish"> <img src="https://www.longdom.org/admin/flags/spain.png">Spanish </a> <a class="dropdown-item" href="https://chinese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Chinese"> <img src="https://www.longdom.org/admin/flags/china.png">Chinese </a> <a class="dropdown-item" href="https://russian.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Russian"> <img src="https://www.longdom.org/admin/flags/russia.png">Russian </a> <a class="dropdown-item" href="https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="German"> <img src="https://www.longdom.org/admin/flags/germany.png">German </a> <a class="dropdown-item" href="https://french.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="French"> <img src="https://www.longdom.org/admin/flags/france.png">French </a> <a class="dropdown-item" href="https://japanese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Japanese"> <img src="https://www.longdom.org/admin/flags/japan.png">Japanese </a> <a class="dropdown-item" href="https://hindi.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Hindi"> <img src="https://www.longdom.org/admin/flags/india.png">Hindi </a> <a class="dropdown-item" href="https://telugu.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Telugu"> <img src="https://www.longdom.org/admin/flags/india.png">Telugu </a> <a class="dropdown-item" href="https://tamil.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Tamil"> <img src="https://www.longdom.org/admin/flags/india.png">Tamil </a> </div> </div>  </nav> </div> </div> </div> </div>  <div class="py-3"> <div class="container-fluid"> <div class="row align-items-center justify-content-between"> <div class="col-12 col-sm-auto"> <h1 class="rockwell fweight-600 mb-0">Relatos de Casos de Oncologia e Câncer</h1> <span class="float-right">ISSN - 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Many of these challenges pertain to the vast heterogeneity in cancers and presentations, patient ineligibility for clinical trials, lack of standardized guidelines to direct management and an incomplete understanding of the molecular mechanisms that contribute to the development of these cancers. We present a case of concurrent diagnoses of Pancreatic Ductal Adenocarcinoma (PDAC) and Acute Myeloid Leukemia (AML) with a comprehensive mutational analysis of the pancreatic tumor, AML blasts, and germline DNA collected from cultured skin fibroblast samples. In addition to some commonly detected mutations (e.g. KRAS Gly12Asp in PDAC and TP53 Met237lle in AML), the genetic testing revealed the presence of DDX41 and MUTYH gene mutations in both germline DNA and tumor tissue specimens. This case underscores the importance of addressing the interplay of genetic, lifestyle and environmental factors in the development of synchronous cancers in an individual, and only by doing so, evidence-based guidelines for early detection and management may be developed.</p> </p> <div class="alert alert-info text-left"><b>Isen莽茫o de responsabilidade :</b> Este resumo foi traduzido utilizando ferramentas de intelig锚ncia artificial e ainda n茫o foi revisado ou verificado.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Compartilhe este artigo</a> <a title="" target="_blank" href="https://www.facebook.com/sharer.php?u=https://portuguese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="" target="_blank" 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