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e-con-boxed e-con e-parent" data-id="5bf8d5f" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-99c240b elementor-widget elementor-widget-heading" data-id="99c240b" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h1 class="elementor-heading-title elementor-size-default">Spatial Transcriptomics</h1> </div> </div> <div class="elementor-element elementor-element-602d4b4 elementor-widget elementor-widget-heading" data-id="602d4b4" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Our end-to-end service is supported by Vizgen MERSCOPE platform, enabling us to provide high-resolution, spatially resolved gene expression data that is crucial for both basic research and clinical applications.</h2> </div> </div> </div> </div> <div class="elementor-element elementor-element-6eafb47 e-flex e-con-boxed e-con e-parent" data-id="6eafb47" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-2f31e82 elementor-widget elementor-widget-heading" data-id="2f31e82" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Firalis Molecular Precision positions itself as a leading certified Vizgen service-provider in Europe.</h2> </div> </div> </div> </div> <div class="elementor-element elementor-element-65b42e7 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent" data-id="65b42e7" data-element_type="container" data-settings="{"animation":"fadeIn","animation_delay":200,"background_background":"gradient"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-98f6558 e-con-full e-flex e-con e-child" data-id="98f6558" data-element_type="container"> <div class="elementor-element elementor-element-6293a1c elementor-widget elementor-widget-heading" data-id="6293a1c" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">What is Spatial Transcriptomics ? </h2> </div> </div> <div class="elementor-element elementor-element-62f7312 elementor-widget elementor-widget-text-editor" data-id="62f7312" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Spatial transcriptomics</strong> is an approach allowing to obtain gene expression data in its spatial context.</p><p>In fact, it allows for the simultaneous detection of thousands of genes within a tissue sample, while preserving its native spatial organization.</p><p>This approach has broad applicability in the fields of biology, medicine, and drug discovery. </p> </div> </div> </div> <div class="elementor-element elementor-element-e7ef3bd e-con-full e-flex e-con e-child" data-id="e7ef3bd" data-element_type="container" data-settings="{"background_background":"classic"}"> </div> </div> </div> <div class="elementor-element elementor-element-774ef49 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent" data-id="774ef49" data-element_type="container" data-settings="{"animation":"fadeIn","animation_delay":300}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-65f81ab e-con-full e-flex e-con e-child" data-id="65f81ab" data-element_type="container" data-settings="{"background_background":"classic"}"> </div> <div class="elementor-element elementor-element-7a2b089 e-con-full e-flex e-con e-child" data-id="7a2b089" data-element_type="container"> <div class="elementor-element elementor-element-dc247c1 elementor-widget elementor-widget-heading" data-id="dc247c1" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Our service uses Vizgen's patented MERFISH technology, which enables the detection of up to 500 genes/panel in a single tissue sample.</h2> </div> </div> <div class="elementor-element elementor-element-91301cf elementor-widget elementor-widget-text-editor" data-id="91301cf" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>The MERFISH technology provides high spatial resolution, allowing for the vizualisation of gene expression patterns at the single-cell level. </p><p>Our genomics experts leverage this cutting-edge technology to offer an end-to-end service, ranging from sample preparation and data generation to analysis and visualization.</p><p>We also provide customized data analysis solutions to aid resarchers in gaining insights from their generated data.</p> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-3721929 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent" data-id="3721929" data-element_type="container" data-settings="{"animation":"fadeIn","animation_delay":300,"shape_divider_bottom":"triangle"}"> <div class="e-con-inner"> <div class="elementor-shape elementor-shape-bottom" data-negative="false"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 1000 100" preserveAspectRatio="none"> <path class="elementor-shape-fill" d="M500,98.9L0,6.1V0h1000v6.1L500,98.9z"/> </svg> </div> <div class="elementor-element elementor-element-fcd8cf8 elementor-widget elementor-widget-heading" data-id="fcd8cf8" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">MERFISH technology principle</h2> </div> </div> <div class="elementor-element elementor-element-79f4799 elementor-widget elementor-widget-text-editor" data-id="79f4799" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>MERFISH is an image-based transcriptomic technology measuring both expression and spatial information of RNA in individual cells from tissue slices. It allows massive multiplexing single molecule FISH measurement.</p><p>Individual RNA species are encoded by error robust barcodes using combinatorial oligonucleotide labeling. Sequential rounds of oligonucleotides hybridization and imaging by a high resolution fluorescence microscope measure barcodes for spatially resolved RNA quantification of up to 500 genes.</p> </div> </div> <div class="elementor-element elementor-element-859d7e6 elementor-widget elementor-widget-image" data-id="859d7e6" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img fetchpriority="high" decoding="async" width="640" height="224" src="https://i0.wp.com/firalismolecularprecision.com/wp-content/uploads/2023/04/Illustration_SpatialT-principle.png?fit=640%2C224&ssl=1" class="attachment-large size-large wp-image-1795" alt="merfish spatial transcriptomics services provider genomics biomarker discovery" data-attachment-id="1795" data-permalink="https://firalismolecularprecision.com/cro-cdmo-services/genomic-services/spatial-transcriptomics-services/illustration_spatialt-principle/" data-orig-file="https://i0.wp.com/firalismolecularprecision.com/wp-content/uploads/2023/04/Illustration_SpatialT-principle.png?fit=4017%2C1403&ssl=1" data-orig-size="4017,1403" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="spatial transcriptomics protocol" data-image-description="<p>merfish spatial transcriptomics services provider genomics biomarker discovery</p> " data-image-caption="<p>merfish spatial transcriptomics services provider genomics biomarker discovery</p> " data-medium-file="https://i0.wp.com/firalismolecularprecision.com/wp-content/uploads/2023/04/Illustration_SpatialT-principle.png?fit=300%2C105&ssl=1" data-large-file="https://i0.wp.com/firalismolecularprecision.com/wp-content/uploads/2023/04/Illustration_SpatialT-principle.png?fit=640%2C224&ssl=1" /> </div> </div> <div class="elementor-element elementor-element-1875fda elementor-align-center elementor-button-info elementor-widget elementor-widget-button" data-id="1875fda" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-lg" href="https://www.science.org/doi/10.1126/science.aaa6090" target="_blank" rel="nofollow"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Read the original publication on " Spatially resolved, highly multiplexed RNA profiling in single cells "</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-a05050e e-flex e-con-boxed e-con e-parent" data-id="a05050e" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-fc98dcb elementor-widget elementor-widget-heading" data-id="fc98dcb" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Conducting a MERFISH experiment</h3> </div> </div> <div class="elementor-element elementor-element-35a440d elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="35a440d" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-f158399 e-flex e-con-boxed e-con e-parent" data-id="f158399" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-109ebc7 e-con-full e-flex e-con e-child" data-id="109ebc7" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-fce1be3 elementor-invisible elementor-widget elementor-widget-icon-box" data-id="fce1be3" data-element_type="widget" data-settings="{"_animation":"fadeIn","_animation_delay":100}" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-content"> <h4 class="elementor-icon-box-title"> <span > Fixation </span> </h4> <p class="elementor-icon-box-description"> Tissue samples are fixed to preserve their structure. </p> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-c711f25 e-con-full e-flex e-con e-child" data-id="c711f25" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-f662cb9 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box" data-id="f662cb9" data-element_type="widget" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-caret-right" viewBox="0 0 192 512" xmlns="http://www.w3.org/2000/svg"><path d="M0 384.662V127.338c0-17.818 21.543-26.741 34.142-14.142l128.662 128.662c7.81 7.81 7.81 20.474 0 28.284L34.142 398.804C21.543 411.404 0 402.48 0 384.662z"></path></svg> </span> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-0136b66 e-con-full e-flex e-con e-child" data-id="0136b66" data-element_type="container"> <div class="elementor-element elementor-element-0e2f89f elementor-invisible elementor-widget elementor-widget-icon-box" data-id="0e2f89f" data-element_type="widget" data-settings="{"_animation":"fadeIn","_animation_delay":200}" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-content"> <h4 class="elementor-icon-box-title"> <span > Hybridization </span> </h4> <p class="elementor-icon-box-description"> Samples are hybridized with specially designed DNA probes. </p> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-76ce56f e-con-full e-flex e-con e-child" data-id="76ce56f" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-844393f elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box" data-id="844393f" data-element_type="widget" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-caret-right" viewBox="0 0 192 512" xmlns="http://www.w3.org/2000/svg"><path d="M0 384.662V127.338c0-17.818 21.543-26.741 34.142-14.142l128.662 128.662c7.81 7.81 7.81 20.474 0 28.284L34.142 398.804C21.543 411.404 0 402.48 0 384.662z"></path></svg> </span> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-21d6f97 e-con-full e-flex e-con e-child" data-id="21d6f97" data-element_type="container"> <div class="elementor-element elementor-element-64ef134 elementor-invisible elementor-widget elementor-widget-icon-box" data-id="64ef134" data-element_type="widget" data-settings="{"_animation":"fadeIn","_animation_delay":300}" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-content"> <h4 class="elementor-icon-box-title"> <span > Imaging </span> </h4> <p class="elementor-icon-box-description"> Use a fluorescence microscope to capture images of the samples. </p> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-d47cd32 e-con-full e-flex e-con e-child" data-id="d47cd32" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-73edeb8 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box" data-id="73edeb8" data-element_type="widget" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-caret-right" viewBox="0 0 192 512" xmlns="http://www.w3.org/2000/svg"><path d="M0 384.662V127.338c0-17.818 21.543-26.741 34.142-14.142l128.662 128.662c7.81 7.81 7.81 20.474 0 28.284L34.142 398.804C21.543 411.404 0 402.48 0 384.662z"></path></svg> </span> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-a727220 e-con-full e-flex e-con e-child" data-id="a727220" data-element_type="container"> <div class="elementor-element elementor-element-07b00fa elementor-invisible elementor-widget elementor-widget-icon-box" data-id="07b00fa" data-element_type="widget" data-settings="{"_animation":"fadeIn","_animation_delay":400}" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-content"> <h4 class="elementor-icon-box-title"> <span > Detection </span> </h4> <p class="elementor-icon-box-description"> Identifying and localizing each RNA molecule based on its fluorescent signal combination. </p> </div> </div> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-14162ef e-flex e-con-boxed e-con e-parent" data-id="14162ef" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-a4a3870 elementor-widget elementor-widget-text-editor" data-id="a4a3870" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Having the MERSCOPE Platform in our labs and leveraging Vizgen’s various panels tailored for different research needs, allows us to map gene expression within your tissue samples with exceptional spatial detail, offering deep insights into tissue architecture and molecular processes.</p><p>This supports a range of applications, including <strong>biomarker discovery</strong>, <strong>understanding disease mechanisms</strong>, and <strong>analyzing cellular heterogeneity</strong>.</p><p>By providing comprehensive spatiotemporal gene expression data, we help you advance your research in <strong>drug development</strong>, <strong>disease modeling</strong>, and <strong>personalized medicine</strong>.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-e66a5b5 e-flex e-con-boxed e-con e-parent" data-id="e66a5b5" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-d0b5de9 elementor-widget elementor-widget-heading" data-id="d0b5de9" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Why Firalis Molecular Precision Is the Best Partner for Your Project</h2> </div> </div> <div class="elementor-element elementor-element-e993780 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="e993780" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-43d2315 e-flex e-con-boxed e-con e-parent" data-id="43d2315" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-83ce2ca e-flex e-con-boxed e-con e-child" data-id="83ce2ca" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-9751639 e-con-full animated-slow e-flex elementor-invisible e-con e-child" data-id="9751639" data-element_type="container" data-settings="{"animation":"fadeIn","animation_delay":200}"> <div class="elementor-element elementor-element-875f2dc elementor-view-default elementor-widget elementor-widget-icon" data-id="875f2dc" data-element_type="widget" data-widget_type="icon.default"> <div class="elementor-widget-container"> <div class="elementor-icon-wrapper"> <div class="elementor-icon"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-users" viewBox="0 0 640 512" xmlns="http://www.w3.org/2000/svg"><path d="M96 224c35.3 0 64-28.7 64-64s-28.7-64-64-64-64 28.7-64 64 28.7 64 64 64zm448 0c35.3 0 64-28.7 64-64s-28.7-64-64-64-64 28.7-64 64 28.7 64 64 64zm32 32h-64c-17.6 0-33.5 7.1-45.1 18.6 40.3 22.1 68.9 62 75.1 109.4h66c17.7 0 32-14.3 32-32v-32c0-35.3-28.7-64-64-64zm-256 0c61.9 0 112-50.1 112-112S381.9 32 320 32 208 82.1 208 144s50.1 112 112 112zm76.8 32h-8.3c-20.8 10-43.9 16-68.5 16s-47.6-6-68.5-16h-8.3C179.6 288 128 339.6 128 403.2V432c0 26.5 21.5 48 48 48h288c26.5 0 48-21.5 48-48v-28.8c0-63.6-51.6-115.2-115.2-115.2zm-223.7-13.4C161.5 263.1 145.6 256 128 256H64c-35.3 0-64 28.7-64 64v32c0 17.7 14.3 32 32 32h65.9c6.3-47.4 34.9-87.3 75.2-109.4z"></path></svg> </div> </div> </div> </div> <div class="elementor-element elementor-element-40196e4 elementor-widget elementor-widget-heading" data-id="40196e4" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Qualified team</h2> </div> </div> <div class="elementor-element elementor-element-a854e3b elementor-widget elementor-widget-text-editor" data-id="a854e3b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Our experts have extensive experience in sequencing and bioinformatics analysis and are committed to providing personalized assistance throughout your entire project for a successful project outcome.</p> </div> </div> </div> <div class="elementor-element elementor-element-c037ed4 e-con-full animated-slow e-flex elementor-invisible e-con e-child" data-id="c037ed4" data-element_type="container" data-settings="{"animation":"fadeIn","animation_delay":200}"> <div class="elementor-element elementor-element-92fd5f7 elementor-view-default elementor-widget elementor-widget-icon" data-id="92fd5f7" data-element_type="widget" data-widget_type="icon.default"> <div class="elementor-widget-container"> <div class="elementor-icon-wrapper"> <div class="elementor-icon"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-desktop" viewBox="0 0 576 512" xmlns="http://www.w3.org/2000/svg"><path d="M528 0H48C21.5 0 0 21.5 0 48v320c0 26.5 21.5 48 48 48h192l-16 48h-72c-13.3 0-24 10.7-24 24s10.7 24 24 24h272c13.3 0 24-10.7 24-24s-10.7-24-24-24h-72l-16-48h192c26.5 0 48-21.5 48-48V48c0-26.5-21.5-48-48-48zm-16 352H64V64h448v288z"></path></svg> </div> </div> </div> </div> <div class="elementor-element elementor-element-d8c1598 elementor-widget elementor-widget-heading" data-id="d8c1598" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">High-quality data</h2> </div> </div> <div class="elementor-element elementor-element-5cb20f5 elementor-widget elementor-widget-text-editor" data-id="5cb20f5" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Our genomics experts leverage cutting-edge technology and quality control measures to ensure high-quality data generation and work closely with you to ensure that your research objectives are met.</p> </div> </div> </div> <div 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176-176-78.8-176-176-176zm92.52 157.26l-37.93 36.96 8.97 52.22c1.6 9.36-8.26 16.51-16.65 12.09L256 393.88l-46.9 24.65c-8.4 4.45-18.25-2.74-16.65-12.09l8.97-52.22-37.93-36.96c-6.82-6.64-3.05-18.23 6.35-19.59l52.43-7.64 23.43-47.52c2.11-4.28 6.19-6.39 10.28-6.39 4.11 0 8.22 2.14 10.33 6.39l23.43 47.52 52.43 7.64c9.4 1.36 13.17 12.95 6.35 19.59z"></path></svg> </div> </div> </div> </div> <div class="elementor-element elementor-element-90b8ac3 elementor-widget elementor-widget-heading" data-id="90b8ac3" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Certified service provider</h2> </div> </div> <div class="elementor-element elementor-element-eac29e1 elementor-widget elementor-widget-text-editor" data-id="eac29e1" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>We are positioned as a leading certified service-provider in Europe for Vizgen’s MERSCOPE Platform. We adhere to the highest standards of quality and performance, ensuring that our clients receive accurate, reliable, and actionable data.</p> </div> </div> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-359918d e-flex e-con-boxed e-con e-parent" data-id="359918d" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-78c197b elementor-widget elementor-widget-heading" data-id="78c197b" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">OUR COMMITMENT</h3> </div> </div> <div class="elementor-element elementor-element-6a14424 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="6a14424" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div 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