CINXE.COM

Nature ハイライト:最も分化能の高い造血幹細胞の特定 | Nature | Nature Portfolio

<!DOCTYPE html> <!--[if lt IE 9]> <html lang="ja" class="ie8"> <![endif]--> <!--[if (gte IE 9)|!(IE)]>--> <html class="html--asia" lang="ja"> <!--<![endif]--> <head> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="apple-itunes-app" content="app-id=847182178"> <meta name="keywords" content="Nature, ネイチャー, science, 科学、科学ニュース、生物学、物理学、遺伝学、天文学、天文物理学、量子物理学、進化学、進化生物学、地球物理学、気候変動、地球科学、材料科学、学際的研究、科学政策、医学、システム生物学、ゲノミクス、トランスクリプトミクス、古生物学、生態学、分子生物学、がん、免疫学、薬理学、発生学、発生生物学、構造生物学、生化学、バイオインフォマティクス、コンピューテーショナルバイオロジー、ナノテクノロジー、プロテオミクス、メタボロミクス、バイオテクノロジー、創薬、環境科学、生命学、海洋生物学、医学研究、神経科学、神経生物学、機能ゲノミクス、分子相互作用、RNA、DNA、細胞周期、シグナル伝達機構、細胞情報伝達"> <meta name="description" content="Natureは、毎週木曜日発行の国際的な総合科学ジャーナルです。掲載される論文は、独創性、重要性、社会性などの観点から査読を受けたもので、時に、科学界のみならず社会にセンセーションを巻き起こすことさえあります。また論文以外にも、社会的関心の高い、信頼性のある科学関連ニュースや、News &amp; Viewsなどの解説記事、社説や批評などを掲載し、幅広い視点から最新の科学をお届けしています。"> <link rel="icon" href="/static/common/img/favicon.ico"> <title>Nature ハイライト:最も分化能の高い造血幹細胞の特定 | Nature | Nature Portfolio</title> <!-- Latest compiled and minified CSS --> <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.2/css/bootstrap.min.css"> <!-- Optional theme --> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/drawer/3.2.0/css/drawer.min.css"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.7.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" type="text/css" href="https://cdn.jsdelivr.net/jquery.slick/1.4.1/slick.css"/> <!-- Base stylesheet --> <link rel="stylesheet" href="/ja-jp/css/general.css"> <!-- Elements stylesheet --> <link href="/dist/css/core.css" media="screen" rel="stylesheet" type="text/css"> <link href="/dist/css/enhanced.css" media="screen" rel="stylesheet" type="text/css"> <link href="/ja-jp/nature/css/styles.css" media="screen" rel="stylesheet" type="text/css" > <link href="/common/css/new-branding.css" media="screen" rel="stylesheet" type="text/css" > <!-- HTML5 shim and Respond.js for IE8 support of HTML5 elements and media queries --> <!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.2/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> <script src="https://api.html5media.info/1.1.4/html5media.min.js"></script> <![endif]--> <meta name="twitter:card" content="summary"/> <meta name="twitter:site" content="@NatureJapan"/> <meta name="twitter:domain" content="natureasia.com"/> <meta name="twitter:title" content="最も分化能の高い造血幹細胞の特定"/> <meta name="twitter:description" content="今回、藤崎譲士(米国ハーバード大学医学系大学院ほか)たちは、一酸化窒素を高発現していて免疫特権を有する造血幹細胞のサブセットと、それらが存在する特殊な骨髄内ニッチについて明らかにしている。"/> <meta name="twitter:image" content="https://www.natureasia.com/common/img/logos/journals/nature-logo-sq.png"/> <!-- Google Tag Manager for Tokyo --> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-NN9H6SH');</script> <!-- End Google Tag Manager --> <!-- Google Tag Services (DFP) --> <script src="/common/js/google-tag-services.js"></script> <script type="text/javascript"> //<!-- GoogleTagParams = {adUnitLevel: "naturejapan/highlights", doi: ["129350"]}; //--> </script> </head> <body class="body--asia drawer drawer--left reading" id="highlights"> <!-- Google Tag Manager (noscript) --> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NN9H6SH" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <!-- End Google Tag Manager (noscript) --> <header class="c-header c-header--clear-style u-pt-16" id="header" data-header> <div id="masthead" class="c-header__row"> <div class="c-header__container"> <!-- top bar menu --> <ul id="logon-box" class="c-header__menu c-header__menu--global u-text-bold register nav navbar-nav navbar-right hidden-xs"> <li id="tb-naturedotcome" class="c-header__item c-header__item--padding c-header__item--hide-md-max"><a href="http://www.nature.com" class="c-header__link" rel="external"><i class="fa fa-globe" aria-hidden="true"></i> nature.com</a></li> <esi:include src="/secure/esi/header-login/ja-jp/japan-navbar-right"> <li id="tb-register" class="c-header__item c-header__item--padding c-header__item--hide-md-max"><a href="#" class="c-header__link"><i class="fa fa-pencil-square-o" aria-hidden="true"></i> サイト登録</a></li> <li id="tb-login" class="c-header__item c-header__item--padding c-header__item--hide-md-max"><a href="#" class="c-header__link"><i class="fa fa-sign-in" aria-hidden="true"></i> ログイン</a></li> </esi:include> <li id="tb-lang" class="c-header__item c-header__item--padding c-header__item--hide-md-max dropdown"> <a href="#" class="c-header__link" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">日本語 <span class="caret"></span></a> <ul class="dropdown-menu"> <li><a href="/en">English</a></li> <li><a href="http://www.naturechina.com/?utm_source=natureasiajp" rel="external">中文(简体)</a></li> </ul> </li> </ul> <!-- end of top bar menu --> <!-- header logo --> <a href="/ja-jp/nature"><img src="/static/common/nature/img/logo-nature-black.svg" class="journal-logo" alt="nature"></a> <!-- end of header logo --> </div> </div> <!-- top nav and drawer nav --> <!--top nav--> <nav id="menu-bar" class="navbar navbar-default"> <div class="container"> <div id="navbar" > <button type="button" class="drawer-toggle drawer-hamburger show-burger-icon"> <span class="sr-only">toggle navigation</span> <span class="glyphicon glyphicon-menu-hamburger" aria-hidden="true"></span> </button> <!-- show on mobile only --> <div id="navbar-brand-mobile" class="hidden-md hidden-lg"><a href="/ja-jp">natureasia.com</a></div> <ul class="nav navbar-nav hidden-sm hidden-xs"> <!-- journal nav --> <li class="hidden-sm hidden-xs nav-home"> <a href="/ja-jp/nature">Journal home</a> </li> <li class="hidden-sm hidden-xs nav-toc"> <a href="/ja-jp/nature/toc">今週号</a> </li> <li class="hidden-sm hidden-xs nav-archive"> <a href="/ja-jp/nature/archive">バックナンバー</a> </li> <li class="hidden-sm hidden-xs nav-supplements"> <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">Supplements <i class="fa fa-caret-down" aria-hidden="true"></i></a> <ul class="dropdown-menu" role="menu"> <li class="dropdown-nature"><a href="/ja-jp/nature/supplements"><i>Nature</i> supplements</a></li> <li><a href="/ja-jp/nature-index/supplements">Nature Index supplements</a></li> <li><a href="/en/nature/special-issues">Special issues</a></li> </ul> </li> <li class="hidden-sm hidden-xs nav-whats-new"> <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">What's new <i class="fa fa-caret-down" aria-hidden="true"></i></a> <ul class="dropdown-menu" role="menu"> <li class="dropdown-highlight"><a href="/ja-jp/nature/pr-highlights">注目のハイライト</a></li> <li class="dropdown-top-ten"><a href="/ja-jp/nature/top-ten">The <i>Nature</i> Top Ten</a></li> <li class="dropdown-interview"><a href="/ja-jp/nature/interview">著者インタビュー</a></li> <li><a href="/ja-jp/ndigest">Nature ダイジェスト</a></li> <li><a href="/ja-jp/nature-cafe">Nature Café</a></li> <li class="dropdown-specials"><a href="/ja-jp/nature/specials"><i>Nature</i> 特別翻訳記事</a></li> </ul> </li> <li class="hidden-sm hidden-xs nav-author"> <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">著者/投稿 <i class="fa fa-caret-down" aria-hidden="true"></i></a> <ul class="dropdown-menu" role="menu"> <li class="dropdown-guide"><a href="/ja-jp/nature/authors/guideline">投稿について</a></li> <li><a href="https://mts-nature.nature.com/cgi-bin/main.plex?utm_source=natureasia&utm_medium=referral&utm_content=jp_content&utm_campaign=NJPN_3_KI_submit_Japanesesite" rel="external">投稿サイト </a></li> <li><a href="/ja-jp/info/reprints/authors">著者リプリント</a></li> <li><a href="/ja-jp/springer-nature-author-services">Springer Nature Author Services</a></li> </ul> </li> <li class="dropdown hidden-sm hidden-xs nav-about"> <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">Journalについて <i class="fa fa-caret-down" aria-hidden="true"></i></a> <ul class="dropdown-menu" role="menu"> <li class="dropdown-about"><a href="/ja-jp/nature/about-journal"><i>Nature</i> について</a></li> <li class="dropdown-na-vs-sci"><a href="/ja-jp/nature/about-journal/nature-vs-science">「ネイチャー」大解剖</a> </li> <li class="dropdown-benefits"><a href="/ja-jp/nature/about-journal/benefits"><i>Nature</i> 定期購読特典</a></li> </ul> </li> </ul> <!-- search --> <ul id="search-icon" class="nav navbar-right"> <li class="dropdown pull-right"> <a href="javascript:void(0)" class="search-dropdown-button dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"><span class="glyphicon glyphicon-search" aria-hidden="true"></span></a> <ul id="search-dropdown" class="dropdown-menu"> <li> <div id="navbar-search"> <form method="get" id="search"> <input type="text" id="search-box" class="addsearch" name="addsearch" placeholder="Search..." autofocus> <button id="search-button" type="submit" disabled><i class="glyphicon glyphicon-search"></i></button> </form> </div> </li> </ul> </li> </ul> <!-- search --> </div><!--/.nav-collapse--> </div> </nav> <!--drawer--> <div role="banner"> <nav class="drawer-nav" role="navigation"> <ul class="drawer-menu"> <!-- links to homepage and other lang websites --> <!-- natureasia.com logo --> <li> <h2><a class="drawer-brand" href="/ja-jp"><img src="/static/common/img/header/logo-natureasia-white.svg" alt="natureasia.com"></a></h2> <button type="button" class="drawer-toggle drawer-hamburger show-x-icon"> <span class="sr-only">toggle navigation</span> <span class="glyphicon glyphicon-remove" aria-hidden="true"></span> </button> </li> <!-- end of natureasia.com logo --> <!-- lang nav --> <li class="drawer-dropdown"> <a class="drawer-menu-item" href="#" data-toggle="dropdown">日本語 <span class="drawer-caret"></span></a> <ul class="drawer-dropdown-menu"> <li><a class="drawer-dropdown-menu-item" href="/en">English</a></li> <li><a class="drawer-dropdown-menu-item" href="http://www.naturechina.com/?utm_source=natureasiajp" rel="external">中文(简体)</a></li> </ul> </li> <!-- end of lang nav --> <!-- links to homepage and other lang websites --> <!-- journal nav --> <li class="drawer-menu-header"><i class="fa fa-book" aria-hidden="true"></i> <i>Nature</i></li> <li><a class="drawer-menu-item" href="/ja-jp/nature">Journal home</a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature/toc">今週号</a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature/archive">バックナンバー</a></li> <li class="drawer-dropdown"> <a class="drawer-menu-item" href="#" data-toggle="dropdown">Supplements <span class="drawer-caret"></span></a> <ul class="drawer-dropdown-menu"> <li><a class="drawer-dropdown-menu-item" href="/ja-jp/nature/supplements"><i>Nature</i> supplements</a></li> <li><a class="drawer-dropdown-menu-item" href="/ja-jp/nature-index/supplements">Nature Index supplements</a></li> <li><a class="drawer-dropdown-menu-item" href="/en/nature/special-issues">Special issues</a></li> </ul> </li> <li class="drawer-menu-header"><i class="fa fa-fire" aria-hidden="true"></i> What's new</li> <li><a class="drawer-menu-item" href="/ja-jp/nature/pr-highlights">注目のハイライト</a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature/top-ten">The <i>Nature</i> Top Ten</a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature/interview">著者インタビュー</a></li> <li><a class="drawer-menu-item journalname" href="/ja-jp/ndigest">Nature ダイジェスト</a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature-cafe">Nature Café</a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature/specials"><i>Nature</i> 特別翻訳記事</a></li> <li class="drawer-menu-header"><i class="fa fa-pencil-square-o" aria-hidden="true"></i> 著者/投稿</li> <li><a class="drawer-menu-item" href="/ja-jp/nature/authors/guideline">投稿について</a></li> <li><a class="drawer-menu-item" href="https://mts-nature.nature.com/cgi-bin/main.plex?utm_source=natureasia&utm_medium=referral&utm_content=jp_content&utm_campaign=NJPN_3_KI_submit_Japanesesite" rel="external">投稿サイト </a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature/authors/reprints">著者リプリント</a></li> <li><a class="drawer-menu-item" href="/ja-jp/springer-nature-author-services">Springer Nature Author Services</a></li> <li class="drawer-menu-header"><i class="fa fa-info-circle" aria-hidden="true"></i> Journalについて</li> <li><a class="drawer-menu-item" href="/ja-jp/nature/about-journal"><i>Nature</i> について</a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature/about-journal/nature-vs-science">「ネイチャー」大解剖</a></li> <li><a class="drawer-menu-item" href="/ja-jp/nature/about-journal/benefits"><i>Nature</i> 定期購読特典</a></li> <!-- end of journal nav --> <!-- secondary nav --> <!-- social icons --> <li id="social"> <div id="twitter"><a href="https://twitter.com/Naturejapan" rel="external"><i class="fa fa-twitter" aria-hidden="true"></i></a></div> <div id="facebook"><a href="https://www.facebook.com/NatureJapan" rel="external"><i class="fa fa-facebook" aria-hidden="true"></i></a></div> <div id="youtube"><a href="http://www.youtube.com/user/NatureVideoChannel" rel="external"><i class="fa fa-youtube" aria-hidden="true"></i></a></div> </li> <!-- end of social icons --> <div class="clearfix"></div> <li class="drawer-menu-header"><i class="fa fa-book" aria-hidden="true"></i> 出版誌</li> <li><a class="drawer-menu-item" href="/ja-jp/sitemap">出版誌一覧</a></li> <li class="drawer-menu-header"><i class="fa fa-flask" aria-hidden="true"></i> 専門分野ゲートウェイ</li> <li><a class="drawer-menu-item" href="/ja-jp/chemistry">化学</a></li> <li><a class="drawer-menu-item" href="/ja-jp/clinical">臨床研究</a></li> <li><a class="drawer-menu-item" href="/ja-jp/earth-env">地球と環境</a></li> <li><a class="drawer-menu-item" href="/ja-jp/life-sci">生命科学</a></li> <li><a class="drawer-menu-item" href="/ja-jp/phys-sci">物理学</a></li> <li class="drawer-menu-header"><i class="fa fa-shopping-cart" aria-hidden="true"></i> 購読情報</li> <li><a class="drawer-menu-item" href="https://www.springernature.com/jp/librarians/licensing" rel="external">法人購読 </a></li> <li><a class="drawer-menu-item" href="/ja-jp/info/personal-subscriptions">個人購読</a></li> <li class="drawer-menu-header"><i class="fa fa-pencil" aria-hidden="true"></i> ネイチャー・リサーチのサービス</li> <li><a class="drawer-menu-item" href="/ja-jp/authors">著者向けサービス</a></li> <li><a class="drawer-menu-item" href="/ja-jp/partnership">パートナーシップ</a></li> <li class="drawer-menu-header"><i class="fa fa-user" aria-hidden="true"></i> マイアカウント</li> <esi:include src="/secure/esi/header-login/ja-jp/japan-header-drawer"><li><a class="drawer-menu-item" href="https://www.natureasia.com/secure/ja-jp/register">サイト登録</a></li> <li><a class="drawer-menu-item" href="https://www.natureasia.com/secure/ja-jp/login">ログイン</a></li> </esi:include> <li class="drawer-menu-header"><i class="fa fa-building" aria-hidden="true"></i> 会社案内</li> <li><a class="drawer-menu-item" href="/ja-jp/info/about/profile">会社概要</a></li> <li><a class="drawer-menu-item" href="/ja-jp/info/about">CEOからのメッセージ</a></li> <li><a class="drawer-menu-item" href="/ja-jp/info">お知らせ</a></li> <li><a class="drawer-menu-item" href="/ja-jp/info/press-releases">プレスリリース</a></li> <li><a class="drawer-menu-item" href="/ja-jp/info/recruit">採用情報</a></li> <li><a class="drawer-menu-item" href="https://support.springernature.com/ja-JP/support/tickets/new" rel="external">各種お問い合わせ </a></li> <li><a class="drawer-menu-item" href="https://support.nature.com/ja-JP/support/solutions" rel="external">ヘルプ </a></li> <li><a class="drawer-menu-item" href="/ja-jp/sitemap">サイトマップ</a></li> <!-- secondary nav --> </ul> </nav> </div> <!-- end of top nav and drawer nav --> </header> <!-- ad space --> <div class="u-container"> <div class="leaderboard"> <!-- LB1 ad slot --> <aside class="c-ad c-ad--728x90 header-leaderboard hidden-xs" style="margin: auto; padding: 0; max-width: 728px; max-height: 90px; overflow-x: hidden; overflow-y: hidden;"> <div id="div-gpt-ad-LB1" class="c-ad__inner"> <script> googletag.cmd.push(function () { googletag.display('div-gpt-ad-LB1'); }); </script> </div> </aside> </div> </div> <!-- breadcrumbs --> <div class="u-container"> <ul class="c-breadcrumbs c-breadcrumbs--font u-text-bold u-mt-32"> <li class="c-breadcrumbs__item"> <a class="c-breadcrumbs__link" href="/ja-jp">Nature Japan</a> <svg class="c-breadcrumbs__chevron" width="12" height="12" aria-hidden="true" focusable="false"> <path d="m5.96738168 4.70639573 2.39518594-2.41447274c.37913917-.38219212.98637524-.38972225 1.35419292-.01894278.37750606.38054586.37784436.99719163-.00013556 1.37821513l-4.03074001 4.06319683c-.37758093.38062133-.98937525.38100976-1.367372-.00003075l-4.03091981-4.06337806c-.37759778-.38063832-.38381821-.99150444-.01600053-1.3622839.37750607-.38054587.98772445-.38240057 1.37006824.00302197l2.39538588 2.4146743.96295325.98624457z" fill-rule="evenodd" transform="matrix(0 -1 1 0 0 10)"></path> </svg> </li> <li class="c-breadcrumbs__item"><a class="c-breadcrumbs__link" href="/ja-jp/nature"><i>Nature</i></a><svg class="c-breadcrumbs__chevron" width="12" height="12" aria-hidden="true" focusable="false"><path d="m5.96738168 4.70639573 2.39518594-2.41447274c.37913917-.38219212.98637524-.38972225 1.35419292-.01894278.37750606.38054586.37784436.99719163-.00013556 1.37821513l-4.03074001 4.06319683c-.37758093.38062133-.98937525.38100976-1.367372-.00003075l-4.03091981-4.06337806c-.37759778-.38063832-.38381821-.99150444-.01600053-1.3622839.37750607-.38054587.98772445-.38240057 1.37006824.00302197l2.39538588 2.4146743.96295325.98624457z" fill-rule="evenodd" transform="matrix(0 -1 1 0 0 10)"></path></svg></li> <li class="c-breadcrumbs__item"><a class="c-breadcrumbs__link" href="/ja-jp/nature/638/8049">ハイライト</a><svg class="c-breadcrumbs__chevron" width="12" height="12" aria-hidden="true" focusable="false"> <path d="m5.96738168 4.70639573 2.39518594-2.41447274c.37913917-.38219212.98637524-.38972225 1.35419292-.01894278.37750606.38054586.37784436.99719163-.00013556 1.37821513l-4.03074001 4.06319683c-.37758093.38062133-.98937525.38100976-1.367372-.00003075l-4.03091981-4.06337806c-.37759778-.38063832-.38381821-.99150444-.01600053-1.3622839.37750607-.38054587.98772445-.38240057 1.37006824.00302197l2.39538588 2.4146743.96295325.98624457z" fill-rule="evenodd" transform="matrix(0 -1 1 0 0 10)"></path> </svg> </li> <li class="c-breadcrumbs__item active">最も分化能の高い造血幹細胞の特定</li> </ul> </div> <div id="page" class="u-container"> <div class="l-with-sidebar"> <!-- main content --> <article class="main-container"> <header> <div class="u-text-right c-card__body--toc"><i>Nature</i> ハイライト</div> <!-- AddThis Share Button BEGIN --> <!-- AddThis Button BEGIN --> <script type="text/javascript"> document.write(unescape('%3C%64%69%76%20%63%6C%61%73%73%3D%22%61%64%64%74%68%69%73%5F%74%6F%6F%6C%62%6F%78%20%61%64%64%74%68%69%73%5F%64%65%66%61%75%6C%74%5F%73%74%79%6C%65%22%20%69%64%3D%22%73%68%61%72%65%2D%63%6F%75%6E%74%22%3E%0A%09%3C%61%20%63%6C%61%73%73%3D%22%61%64%64%74%68%69%73%5F%62%75%74%74%6F%6E%5F%66%61%63%65%62%6F%6F%6B%5F%6C%69%6B%65%22%20%66%62%3A%6C%69%6B%65%3A%6C%61%79%6F%75%74%3D%22%62%75%74%74%6F%6E%5F%63%6F%75%6E%74%22%3E%3C%2F%61%3E%0A%09%3C%61%20%63%6C%61%73%73%3D%22%61%64%64%74%68%69%73%5F%62%75%74%74%6F%6E%5F%74%77%65%65%74%22%3E%3C%2F%61%3E%0A%3C%2F%64%69%76%3E')); </script> <script type="text/javascript"> var addthis_config = { data_ga_property: 'UA-1577199-1', data_ga_social: true }; </script> <script type="text/javascript" src="//s7.addthis.com/js/300/addthis_widget.js#pubid=edenbach"></script> <!-- AddThis Button END --> <!-- AddThis Share Button END --> <h1><span class="subject">幹細胞:</span>最も分化能の高い造血幹細胞の特定</h1> <p><time datetime="2025-02-06">2025年2月6日</time> <i>Nature</i> <b>638</b>, 8049</p> </header> <p>今回、藤崎譲士(米国ハーバード大学医学系大学院ほか)たちは、一酸化窒素を高発現していて免疫特権を有する造血幹細胞のサブセットと、それらが存在する特殊な骨髄内ニッチについて明らかにしている。</p> <!-- clearfix for highlights with floating image --> <div class="clearfix"></div> <div id="related-articles"> <p> <div>Article<span> p.206</span></div> doi: 10.1038/s41586-024-08352-6</p> <div class="c-grid c-grid--3-col-even u-mb-32"> <a href="/ja-jp/nature/638/8049/s41586-024-08352-6/%E9%AA%A8%E9%AB%84%E3%81%AE%E3%83%8B%E3%83%83%E3%83%81%E3%81%AF%E5%B9%B9%E7%B4%B0%E8%83%9E%E3%81%AE%E9%9A%8E%E5%B1%A4%E6%80%A7%E3%81%A8%E5%85%8D%E7%96%AB%E5%AF%9B%E5%AE%B9%E3%82%92%E5%88%B6%E5%BE%A1%E3%81%99%E3%82%8B" rel="external" class="u-button u-button--padding u-button--ghost u-button--block">日本語要約 <i class="fa fa-file-text-o"></i></a> <a href="https://www.nature.com/articles/s41586-024-08352-6" rel="external" class="u-button u-button--padding u-button--ghost u-button--block">Full Text <i class="fa fa-file-text-o"></i></a> <a href="https://www.nature.com/articles/s41586-024-08352-6.pdf" rel="external" class="u-button u-button--padding u-button--ghost u-button--block">PDF <i class="fa fa-file-pdf-o"></i></a> </div> </div> <!-- highlight list --> <div class="u-mt-32"> <div> <h2 class="c-section-heading">2025年2月6日号の<span> Nature</span> ハイライト</h2> </div> <div> <ul> <li class="u-mb-16"><h3><span class="subject">惑星科学:</span><a href="/ja-jp/nature/highlights/129338" title="イオに浅いマグマオーシャンは存在しない">イオに浅いマグマオーシャンは存在しない</a></h3></li> <li class="u-mb-16"><h3><span class="subject">量子シミュレーション:</span><a href="/ja-jp/nature/highlights/129339" title="大規模量子シミュレーターによる量子粗大化現象の観測">大規模量子シミュレーターによる量子粗大化現象の観測</a></h3></li> <li class="u-mb-16"><h3><span class="subject">統計物理学:</span><a href="/ja-jp/nature/highlights/129340" title="大規模群衆によって生み出される振動運動">大規模群衆によって生み出される振動運動</a></h3></li> <li class="u-mb-16"><h3><span class="subject">高分子化学:</span><a href="/ja-jp/nature/highlights/129341" title="2つの手法で重合させた分解性架橋樹脂">2つの手法で重合させた分解性架橋樹脂</a></h3></li> <li class="u-mb-16"><h3><span class="subject">化学:</span><a href="/ja-jp/nature/highlights/129342" title="C&ndash;H結合をC&ndash;Cl結合に変換する銅依存性酵素">C&ndash;H結合をC&ndash;Cl結合に変換する銅依存性酵素</a></h3></li> <li class="u-mb-16"><h3><span class="subject">気候科学:</span><a href="/ja-jp/nature/highlights/129343" title="最終間氷期を生き延びた南極棚氷">最終間氷期を生き延びた南極棚氷</a></h3></li> <li class="u-mb-16"><h3><span class="subject">保全生物学:</span><a href="/ja-jp/nature/highlights/129344" title="淡水動物は世界的に絶滅の危機にある">淡水動物は世界的に絶滅の危機にある</a></h3></li> <li class="u-mb-16"><h3><span class="subject">古生物学:</span><a href="/ja-jp/nature/highlights/129345" title="白亜紀の南極に存在した独特なカモ類">白亜紀の南極に存在した独特なカモ類</a></h3></li> <li class="u-mb-16"><h3><span class="subject">分子生物学:</span><a href="/ja-jp/nature/highlights/129346" title="母親由来のX染色体が脳を老化させる">母親由来のX染色体が脳を老化させる</a></h3></li> <li class="u-mb-16"><h3><span class="subject">神経科学:</span><a href="/ja-jp/nature/highlights/129347" title="脳細胞の老化や若返りの有望な媒介因子">脳細胞の老化や若返りの有望な媒介因子</a></h3></li> <li class="u-mb-16"><h3><span class="subject">発達障害:</span><a href="/ja-jp/nature/highlights/129348" title="異なる滑脳症に共通する基盤">異なる滑脳症に共通する基盤</a></h3></li> <li class="u-mb-16"><h3><span class="subject">植物科学:</span><a href="/ja-jp/nature/highlights/129349" title="植物の葉を病原菌から守る免疫的な細胞状態の特定">植物の葉を病原菌から守る免疫的な細胞状態の特定</a></h3></li> <li class="u-mb-16"><h3><span class="subject">幹細胞:</span><a href="/ja-jp/nature/highlights/129350" title="最も分化能の高い造血幹細胞の特定">最も分化能の高い造血幹細胞の特定</a></h3></li> <li class="u-mb-16"><h3><span class="subject">代謝:</span><a href="/ja-jp/nature/highlights/129351" title="宿主代謝と腸内細菌の機能を調和させる胆汁酸抱合体">宿主代謝と腸内細菌の機能を調和させる胆汁酸抱合体</a></h3></li> <li class="u-mb-16"><h3><span class="subject">医学研究:</span><a href="/ja-jp/nature/highlights/129352" title="がんは免疫回避にミトコンドリアも利用する">がんは免疫回避にミトコンドリアも利用する</a></h3></li> <li class="u-mb-16"><h3><span class="subject">医学研究:</span><a href="/ja-jp/nature/highlights/129353" title="個別化核酸医薬を迅速に評価できる患者由来細胞モデル">個別化核酸医薬を迅速に評価できる患者由来細胞モデル</a></h3></li> <li class="u-mb-16"><h3><span class="subject">がん:</span><a href="/ja-jp/nature/highlights/129354" title="アスパラギン酸は播種したがん細胞の翻訳を変化させて肺転移を促す">アスパラギン酸は播種したがん細胞の翻訳を変化させて肺転移を促す</a></h3></li> <li class="u-mb-16"><h3><span class="subject">分子生物学:</span><a href="/ja-jp/nature/highlights/129355" title="並んだヌクレオソームが転写因子をエンハンサーへと誘導する">並んだヌクレオソームが転写因子をエンハンサーへと誘導する</a></h3></li> <li class="u-mb-16"><h3><span class="subject">構造生物学:</span><a href="/ja-jp/nature/highlights/129356" title="非リボソームペプチド合成酵素の構造をつかまえる">非リボソームペプチド合成酵素の構造をつかまえる</a></h3></li> </ul> </div> </div> <p class="return"><a href="/ja-jp/nature/toc">目次へ戻る</a></p> </article> <!-- end of main content --> <!-- sidebar --> <div class="l-with-sidebar__sidebar"> <div class="u-mb-16"> <a href="/ja-jp/collections/covid-19"><img src="https://www.natureasia.com/ja-jp/image/2606/covid-19-sidebar.jpg" alt="COVID-19特別翻訳記事" class="img-responsive" style="display: inline-block !important;"></a> </div> <section> <nav> <ul class="u-h3 c-sidebar-ul c-panel c-panel--gray"> <li class="u-mb-16"> <a href="http://www.nature.com/nature" rel="external"><i class="fa fa-globe c-sidebar-icon-box"></i> 英語のサイト</a> </li> <li class="u-mb-16"><a href="/ja-jp/sitemap"><i class="fa fa-book c-sidebar-icon-box" aria-hidden="true"></i> 出版誌一覧</a></li> <li class="u-mb-16"><a href="/ja-jp/open-access"><i class="fa fa-cogs c-sidebar-icon-box"></i> オープンアクセス</a></li> <li class="u-mb-16"><a href="/ja-jp/partnership"><i class="fa fa-bullseye c-sidebar-icon-box"></i> パートナーシップ</a></li> <li class="u-mb-16"><a href="https://www.springernature.com/jp/librarians/licensing" rel="external"><i class="fa fa-laptop c-sidebar-icon-box"></i> サイトライセンス</a></li> <li class="u-mb-16"><a href="https://www.natureasia.com/secure/ja-jp/register"><i class="fa fa-envelope c-sidebar-icon-box"></i> メールマガジン登録</a></li> <li><a href="/ja-jp/nature-index"><i class="fa fa-bar-chart c-sidebar-icon-box"></i> Nature Index</a></li> </ul> <div class="u-h3 c-panel c-panel--gray u-mb-24 u-text-center"> <p>Nature Japanとつながろう:</p> <div> <a title="Twitterでフォローする" href="https://twitter.com/NatureJapan" rel="external"><i class="fa fa-twitter-square c-sidebar-social-icon"></i></a> <a title="「いいね!」する" href="https://www.facebook.com/NatureJapan" rel="external"><i class="fa fa-facebook-square c-sidebar-social-icon"></i></a> <a title="YouTubeで動画を見る" href="http://www.youtube.com/user/NatureVideoChannel" rel="external"><i class="fa fa-youtube-square c-sidebar-social-icon"></i></a> <a title="RSSフィード" href="/ja-jp/rss"><i class="fa fa-rss-square c-sidebar-social-icon"></i></a> </div> </div> </nav> </section> <section class="c-panel c-panel--gray u-pa-16 u-h2 u-mb-24"> <h2 class="u-mb-16 u-h4">ネイチャーの人気コンテンツ</h2> <ol> <li> <a href="/ja-jp/nature/highlights/129354">アスパラギン酸は播種したがん細胞の翻訳を変化させて肺転移を促す</a> </li> <li> <a href="/ja-jp/nature/highlights/129353">個別化核酸医薬を迅速に評価できる患者由来細胞モデル</a> </li> <li> <a href="/ja-jp/nature/highlights/129352">がんは免疫回避にミトコンドリアも利用する</a> </li> <li> <a href="/ja-jp/nature/highlights/129351">宿主代謝と腸内細菌の機能を調和させる胆汁酸抱合体</a> </li> <li> <a href="/ja-jp/nature/highlights/129350">最も分化能の高い造血幹細胞の特定</a> </li> <li> <a href="/ja-jp/nature/highlights/129349">植物の葉を病原菌から守る免疫的な細胞状態の特定</a> </li> <li> <a href="/ja-jp/nature/highlights/129348">異なる滑脳症に共通する基盤</a> </li> <li> <a href="/ja-jp/nature/highlights/129347">脳細胞の老化や若返りの有望な媒介因子</a> </li> <li> <a href="/ja-jp/nature/highlights/129346">母親由来のX染色体が脳を老化させる</a> </li> <li> <a href="/ja-jp/nature/highlights/129345">白亜紀の南極に存在した独特なカモ類</a> </li> </ol> </section> <section> <!-- inpage ad code --> <!-- MPU1 ad slot --> <div class="u-mb-16 u-text-center"> <img src="/static/common/img/ad-header.gif" class="ad-header" width="90" height="7" alt="advertisement"/><br/> <div id="div-gpt-ad-MPU1" style="max-width: 300px; max-height: 250px; margin: 0 auto; overflow-x: hidden;"> <script> googletag.cmd.push(function () { googletag.display('div-gpt-ad-MPU1'); }); </script> </div> </div> <!-- end inpage ad code --> </section> <section class="c-panel c-panel--gray u-mb-16"> <nav> <h2 class="u-mb-16 u-h4">専門分野ゲートウェイ</h2> <ul class="c-sidebar-ul c-sidebar-image-list"> <li class="c-icon__yellow-shape"><a href="/ja-jp/chemistry">化学</a></li> <li class="c-icon__green-dots"><a href="/ja-jp/clinical">臨床研究</a></li> <li class="c-icon__green-environment"><a href="/ja-jp/earth-env">地球と環境</a></li> <li class="c-icon__yellow-shape-b"><a href="/ja-jp/life-sci">生命科学</a></li> <li class="c-icon__purple-shape"><a href="/ja-jp/phys-sci">物理学</a></li> </ul> </nav> </section> </div> <!-- end of sidebar --> </div> </div><!-- end of row content --> <!-- footer --> <footer> <div class="c-footer"> <div class="c-footer__container"> <div class="c-footer__grid"> <div class="c-footer__group"> <h3 class="c-footer__heading">Springer Nature について</h3> <ul class="c-footer__list"> <li class="c-footer__item"> <a href="/ja-jp/info/about">CEOからのメッセージ</a> </li> <li class="c-footer__item"> <a href="/ja-jp/info/about/profile">会社案内</a> </li> <li class="c-footer__item"> <a href="/ja-jp/info/press-releases">プレスリリース</a> </li> <li class="c-footer__item"> <a href="/ja-jp/info/about/map">アクセスマップ</a> </li> <li class="c-footer__item"> <a href="/ja-jp/info/recruit">採用情報</a> </li> <li class="c-footer__item"> <a href="https://support.springernature.com/ja-JP/support/tickets/new">各種お問い合わせ</a> </li> </ul> </div> <div class="c-footer__group"> <h3 class="c-footer__heading">ディスカバリー</h3> <ul class="c-footer__list"> <li class="c-footer__item"> <a href="/ja-jp/sitemap">出版誌リスト</a> </li> <li class="c-footer__item"> <a href="https://www.nature.com/research-intelligence/">Nature Research Intelligence</a> </li> <li class="c-footer__item"> <a href="https://www.nature.com/nature-index/">Nature Index</a> </li> <li class="c-footer__item"> <a href="https://www.springernature.com/jp/librarians/tools-services/implement/discovery/discovery-services-new">ディスカバリーサービス</a> </li> <li class="c-footer__item"> <a href="/ja-jp/interviews">著者インタビュー</a> </li> <li class="c-footer__item"> <a href="/ja-jp/partner-contents">Partner Contents</a> </li> </ul> </div> <div class="c-footer__group"> <h3 class="c-footer__heading">情報</h3> <ul class="c-footer__list"> <li class="c-footer__item"> <a href="/ja-jp/info">インフォメーション</a> </li> <li class="c-footer__item"> <a href="/ja-jp/open-access">オープンアクセス</a> </li> <li class="c-footer__item"> <a href="/ja-jp/info/personal-subscriptions">個人 / 学生購読について</a> </li> <li class="c-footer__item"> <a href="/ja-jp/info/price-list/personal">個人 / 学生購読価格表</a> </li> <li class="c-footer__item"> <a href="/secure/ja-jp/subscribe/single">各号の購入</a> </li> </ul> </div> <div class="c-footer__group"> <h3 class="c-footer__heading">著者・研究者向けサービス</h3> <ul class="c-footer__list"> <li class="c-footer__item"> <a href="/ja-jp/info/reprints/authors">著者リプリント</a> </li> <li class="c-footer__item"> <a href="/ja-jp/nature/authors/guideline">Nature 投稿について</a> </li> <li class="c-footer__item"> <a href="/ja-jp/springer-nature-author-services">Springer Nature Author Services</a> </li> <li class="c-footer__item"> <a href="/ja-jp/partnership/services/masterclasses">Nature Masterclasses</a> </li> <li class="c-footer__item"> <a href="/ja-jp/partnership/services/academies">Nature Masterclasses-Expert Trainer-Led Workshops</a> </li> <li class="c-footer__item"> <a href="/ja-jp/partnership/services/online-solution/value">著者向けソリューション</a> </li> </ul> </div> <div class="c-footer__group"> <h3 class="c-footer__heading">図書館・機関向けサービス</h3> <ul class="c-footer__list"> <li class="c-footer__item"> <a href="https://www.springernature.com/jp/librarians">図書館の皆様へ</a> </li> <li class="c-footer__item"> <a href="https://www.springernature.com/jp/librarians/tools-services/implement/librarianportal">管理者用ポータル</a> </li> <li class="c-footer__item"> <a href="/ja-jp/open-access/press-releases">オープンアクセス推進の歩み</a> </li> <li class="c-footer__item"> <a href="https://www.springernature.com/jp/librarians/licensing">ライセンス情報</a> </li> </ul> </div> <div class="c-footer__group"> <h3 class="c-footer__heading">パートナーシップと広告</h3> <ul class="c-footer__list"> <li class="c-footer__item"> <a href="/ja-jp/partnership">パートナーシップ</a> </li> <li class="c-footer__item"> <a href="/ja-jp/partnership/services/branded-contents">ブランデッド・コンテンツ</a> </li> <li class="c-footer__item"> <a href="/ja-jp/partnership/services/spotlight-focalpoint">Spotlight / Focal Point</a> </li> <li class="c-footer__item"> <a href="/ja-jp/nature-cafe">Nature Café</a> </li> </ul> </div> <div class="c-footer__group"> <h3 class="c-footer__heading">キャリア開発</h3> <ul class="c-footer__list"> <li class="c-footer__item"> <a href="https://www.nature.com/naturecareers">Nature Careers</a> </li> <li class="c-footer__item"> <a href="https://conferences.nature.com/">Nature Conferences</a> </li> </ul> </div> <div class="c-footer__group"> <h3 class="c-footer__heading">地域別ウェブサイト</h3> <ul class="c-footer__list"> <li class="c-footer__item"> <a href="https://www.nature.com/natafrica">Nature Africa</a> </li> <li class="c-footer__item"> <a href="http://www.naturechina.com/">Nature China</a> </li> <li class="c-footer__item"> <a href="https://www.nature.com/nindia">Nature India</a> </li> <li class="c-footer__item"> <a href="https://www.nature.com/natitaly">Nature Italy</a> </li> <li class="c-footer__item"> <a href="/ja-jp/">Nature Japan</a> </li> <li class="c-footer__item"> <a href="https://www.nature.com/nmiddleeast/">Nature Middle East</a> </li> </ul> </div> </div> <div class="c-footer__container"> <ul class="c-footer__links"> <li class="c-footer__item"> <a class="c-footer__link" href="/ja-jp/info/privacy">プライバシー規約</a> </li> <li class="c-footer__item"> <a class="c-footer__link" href="/ja-jp/info/isms-policy">ISMS 基本方針</a> </li> <li class="c-footer__item"> <button style="background: rgb(47, 47, 47); border: 1px soligit cd rgb(47, 47, 47);text-decoration: underline;" class="c-footer__link" onclick="javascript:;" data-cc-action="preferences" data-track="click" data-track-action="manage cookies" data-track-label="link" >プライバシーの選択/Cookieの管理</button> </li> <li class="c-footer__item"> <a class="c-footer__link" href="/ja-jp/info/transactions">特定商取引に基づく表示</a> </li> <li class="c-footer__item"> <a class="c-footer__link" href="https://support.nature.com/ja-JP/support/solutions">ヘルプ</a> </li> </ul> </div> </div> <div class="c-footer__container"> <a href="https://www.springernature.com/" class="c-footer__link"> <img src="https://www.natureasia.com/static/common/img/footer/sn-logo-white.svg" alt="Springer Nature" loading="lazy" width="200" height="20" /> </a> <p class="c-footer__legal" data-test="copyright"> &copy; 2025 Springer Nature Limited </p> </div> </div> </footer> <!-- end footer --> </div><!-- end of container --> <!-- pmark & isms jpn & eng only --> <div id="privacy-logos" class="container"> <div class="row"> <!--<a href="http://www.isms.jipdec.or.jp/isms.html" rel="external" title="ISMS適合性評価制度"><img src="/common/img/footer/isms-logo.png" width="150" height="75" alt="ISMS適合性評価制度" id="isms" /></a>--> <a href="http://privacymark.jp" rel="external" title="プライバシーマーク制度"><img src="/static/common/img/footer/pmark-logo-jpn.png" alt="プライバシーマーク制度" id="pmark" /></a> </div> </div> <!-- back to top btn --> <a id="backTop"><i class="fa fa-angle-up"></i></a> <!-- Bootstrap core JavaScript ================================================== --> <!-- Placed at the end of the document so the pages load faster --> <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.11.1/jquery.min.js"></script> <!-- Latest compiled and minified JavaScript --> <script src="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.2/js/bootstrap.min.js"></script> <script src="https://www.natureasia.com/ja-jp/partnership/js/bootstrap-tour.js"></script> <script src="https://www.natureasia.com/ja-jp/partnership/js/intro.js"></script> <!-- IE10 viewport hack for Surface/desktop Windows 8 bug --> <script src="/common/js/ie10-viewport-bug-workaround.js"></script> <script src="/common/js/external/external-ja-jp.js"></script> <script src="/common/js/jquery.backTop.min.js"></script> <script src="/common/js/jquery.cookie.js"></script> <script> function startTour() { var tour = introJs() tour.setOption('tooltipPosition', 'auto'); tour.setOption('positionPrecedence', ['left', 'right', 'top', 'bottom']); tour.start(); } </script> <script> $(document).ready( function() { $('#backTop').backTop({ // the scroll position in px from the top 'position' : 400, // scroll animation speed 'speed' : 500, // red, white, black or green 'color' : 'theme-color', }); }); </script> <!-- drawer js menu --> <script src="https://cdnjs.cloudflare.com/ajax/libs/iScroll/5.1.3/iscroll.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/drawer/3.2.0/js/drawer.min.js"></script> <script src="/common/js/drawer-fix.js"></script> <script> // Scroll to top button $(function() { var scroll = $(document).scrollTop(); if (scroll > 3) { $('body,html').animate({scrollTop: scroll+1}); $('body,html').animate({scrollTop: scroll-1}); } }); </script> <script> // Activate tooltips $(function () { $('[data-toggle="tooltip"]').tooltip() }) </script> <script> $(function () { $('[data-toggle="popover"]').popover({ trigger: 'hover', html: 'true', } ); }); </script> <script> function toggleChevron(e) { $(e.target) .prev('.panel-heading') .find("span.indicator") .toggleClass('glyphicon-chevron-down glyphicon-chevron-up'); } $('#accordion').on('hidden.bs.collapse', toggleChevron); $('#accordion').on('shown.bs.collapse', toggleChevron); </script> <script> // Nature Digest filters $(function() { $('#keyword-side').change(function() { window.location = '/ja-jp/ndigest/filters?' + $.param({tag: $(this).val()}); }); }); </script> <script type="text/javascript" src="/common/js/jquery.matchHeight.js"></script> <script> $(function(){ $('.matchHeight').matchHeight(); }); </script> <!-- tracking for manuscript submission system outbound links --> <script type="text/javascript"> //<!-- $(function () { $('head').append('<style>#maintenance-message { display: none; }</style>'); }); //--> </script> <script type="text/javascript" src="https://addsearch.com/js/?key=ebc194c06f94d3874adcb3ae820c94e1"></script> <script type="text/javascript"> //<!-- $(document).ready(function() { // Prevent the form submission. $('#search').on('submit', function(e) { e.preventDefault(); }); // If search toggle button is selected, auto-focus on search box. $('.search-dropdown-button').on('click touchend', function() { $('#search-box').focus(); }); }); //--> </script> <script type="text/javascript" src="/common/js/jquery.esi-parser.js"></script> <script type="text/javascript"> //<!-- $(function() { console.log('Unknown Journal - MTS link'); $('.ga-mts-goal').click(function(e) { e.preventDefault(); var link = $(this).attr('href'); var j = $(this).attr('data-journal'); var relOrNotRel = $(this).attr('rel'); ga('webPub.send', 'event', { eventCategory: 'link', eventAction: 'click', eventLabel: j + ' - MTS link', transport: 'beacon', hitCallback: function() { if (relOrNotRel !== 'external') { window.location = link; } } }); return false; }); }); //--> </script> </body> </html>

Pages: 1 2 3 4 5 6 7 8 9 10