Cultrex Basement Membrane Extract, PathClear 3432-010-01: R&D Systems

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This extract provides a natural extracellular matrix hydrogel that polymerizes at 37\u00b0C to form a reconstituted basement membrane. Cultrex BME can be used in multiple applications, including maintaining growth or promoting differentiation of primary endothelial, epithelial, smooth muscle, stem cells, and organoid/3D cell cultures. It can also be utilized in cell attachment, neurite outgrowth, angiogenesis, </em>in vitro</em> cell invasion, and </em>in vivo</em> tumorigenicity assays.<br />\n<br />\nBasement membranes are continuous sheets of specialized extracellular matrix that form an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma and that play an essential role in tissue organization by influencing cell adhesion, migration, proliferation, and differentiation. The major components of BME include laminin, collagen IV, entactin, and heparin sulfate proteoglycans. 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id="content_column"> <div class="ds_title_table"> <h1 class="ds_title">Cultrex Basement Membrane Extract, PathClear </h1> <div class="dsSprite_rnd ds_brand_logo ds_rnd_logo"></div> </div> <div class="product_meta"> <span class="category_number">Catalog #: 3432-010-01</span> <br/> <span class="citations"> <a href="#product-citations" id="citation_count" class="jump_to" data-tab="3" data-tabname="product-citations"> 52 Citations </a> </span> <span class="reviews review_stars_5"> <a href="#product-reviews" id="product_reviews" class="jump_to" data-tab="6" data-tabname="product-reviews"> 9 Reviews </a> </span> <a href="/reviews/3432-010-01" rel="nofollow"><span class="submit_review"><button class="btn btn-quaternary">Submit a Review</button></span></a> <span class="datasheet_link"> <a href="#product-datasheets">Datasheet / COA / SDS</a> </span> </div> <div class="product_info">Basement Membrane Extract for use in multiple culture applications<br />Try it on your cultures! <a class="orange_button" href="https://www.bio-techne.com/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/sample-request">Request a Sample of Cultrex BME</a></div>  <div class="product_wrapper row"> <div class="product_ordering_wrapper col-xs-12 col-md-8 col-md-push-4"> <div class="product_ordering"> <form action="/products/cultrex-basement-membrane-extract-pathclear_3432-010-01" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block">     <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th class="ds_availability_column mobile-hide">Availability</th> <th class="ds_size_price_column">Size / Price</th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="3432-001-01"> <td class="dat_catalog_column">3432-001-01</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-3432-001-01 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No. 3432-010-01 - Cultrex Basement Membrane Extract, PathClear" href="https://resources.rndsystems.com/images/datasheets/3432-010-01_cultrex-basement-membrane-extract-pathclear-45202084641.png"> <img fetchpriority="high" src="https://resources.rndsystems.com/images/datasheets/3432-010-01_cultrex-basement-membrane-extract-pathclear-45202084641.png" class="img-fluid" alt="Cultrex Basement Membrane Extract" title="Cultrex Basement Membrane Extract"> </a> <div class="search_image_other_count"> <span class="search_more_images">1 Image</span> </div> </div> </div> <div id="extra_images overview-images" class="hidden"> </div> </div> <div class="product_info_wrapper"> </div> <div id="view-more-target" class="datasheet_section_element"> View <a href="/target/basement-membrane-extracts">All Products for Basement Membrane Extracts</a> </div> </div>  <div class="tabbed_content" id="rnd_atlantabio">  <div id="ds_tabs" class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details" id="dsTabs_product-details"> <span>Product Details</span> </div> <div class="tab tab_3" data-tab="3" data-tabname="product-citations" id="dsTabs_product-citations"> <span>Citations (52)</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="faqs" id="dsTabs_faqs"> <span>FAQs</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="product-reviews" id="dsTabs_product-reviews"> <span> Reviews (9) </span> </div> </div>  <div class="tab_content tab_1 tab_open" data-tab="1" data-tabname="product-details" id="product-details"> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_summary" id="product-anchor-ds_summary">Summary</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_datasheets" id="product-anchor-ds_datasheets">Product Datasheets</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_data_examples" id="product-anchor-ds_data_examples">Data Images</a> </div> <div id="ds_summary" class="datasheet_section"> <h2>Cultrex Basement Membrane Extract, PathClear Summary</h2> Cultrex Basement Membrane Extract (BME) is an extracellular matrix hydrogel that has been used extensively in general cell culture applications to study cell attachment, proliferation, and invasion. <div class="clear"> </div> <h3 class="subheader18">Key Benefits</h3> <p><span style="width:25px;display:inline-block;"></span>• Ideal for general cell culture application<br /><span style="width:25px;display:inline-block;"></span>• Polymerizes at 37°C to form a reconstituted basement membrane<br /><span style="width:25px;display:inline-block;"></span>• Quality controlled for peformance consistency</p> <h3 class="subheader18">Why Use Cultrex BME?</h3> <p>Cultrex Basement Membrane Extract (BME) is a soluble form of basement membrane purified from Engelbreth-Holm-Swarm (EHS) tumor. This extract provides a natural extracellular matrix hydrogel that polymerizes at 37°C to form a reconstituted basement membrane. Cultrex BME can be used in multiple applications, including maintaining growth or promoting differentiation of primary endothelial, epithelial, smooth muscle, stem cells, and organoid/3-D cell cultures. It can also be utilized in cell attachment, neurite outgrowth, angiogenesis, </em>in vitro</em> cell invasion, and </em>in vivo</em> tumorigenicity assays.<br /> <br /> Basement membranes are continuous sheets of specialized extracellular matrix that form an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma and that play an essential role in tissue organization by influencing cell adhesion, migration, proliferation, and differentiation. The major components of BME include laminin, collagen IV, entactin, and heparin sulfate proteoglycans.</p> <h3 class="subheader18 mt-1">Specifications</h3> <div class="ds_table summary_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Source</div> <div class="ds_table_cell summary_table_data">Murine Engelbreth-Holm-Swarm (EHS) tumor</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Sterility Testing</div> <div class="ds_table_cell summary_table_data">No bacterial or fungal growth detected following 14 days in culture</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Testing Cell Culture</div> <div class="ds_table_cell summary_table_data"><b>Tube Formation Assay</b> - Cultrex BME supports formation of capillary-like structures by human (HBMVEC; HUVEC) or mouse (SVEC4-10) endothelial cells in a tube formation assay.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Viral Testing</div> <div class="ds_table_cell summary_table_data">Tested negative by PCR test for a total of 31 organisms and viruses, including: mycoplasma, 17 bacterial and virus strains typically included in mouse antibody production (MAP) testing, and 13 additional murine infectious agents including LDEV.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Stability</div> <div class="ds_table_cell summary_table_data">Product is stable for at least two years from date of manufacture when stored at ≤ -70 °C. See lot specific Certificate of Analysis for expiration date.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Shipping Conditions</div> <div class="ds_table_cell summary_table_data">The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Storage</div> <div class="ds_table_cell summary_table_data">Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Species</div> <div class="ds_table_cell summary_table_data">Mouse</div> </div> </div> </div> <h3>Limitations</h3> <p>For research use only. Not for diagnostic use.</p> </div> <div class="datasheet_section" id="product-datasheets"> <h2 id="ds_datasheets">Product Datasheets</h2> <div class="product_datasheets"> <span class="sds-message hide"> <p class="sds-label">You must select a language.</p> <span class="close_sds_message">x</span> </span> <div class="ds_document"> <a id="cfpdf" href="https://resources.rndsystems.com/pdfs/datasheets/3432-001-01.pdf?v=20241123" class="datasheets-link " target="_blank" rel="noreferrer nofollow">Product Datasheet</a> </div> <div class="ds_document"> <div class="ds_pdfData"><a class="datasheets-link" href="https://www.rndsystems.com/cofas/cultrex-basement-membrane-extract-pathclear_3432-010-01">COA</a> </div> </div> <div class="ds_document sds_link"> <a class="sds_non_cf datasheets-link non_cf_download_link" target="_blank" rel="noreferrer" data-path="https://aero.bio-techne.com/sds/pdf/3432-010-01?v=20241123">SDS</a> </div> </div> </div> <div id="customer_also_purchased_block" class="loader" data-catalogId="3432-010-01"></div> </div>   <div class="tab_content tab_3" data-tab="3" data-tabname="product-citations" id="citations"> <a id="citations_section"></a> <h2><span class="citations">Citations for Cultrex Basement Membrane Extract, PathClear</h2> <div id="citation"> <a id="dsTabCitations"></a> <p> R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. </p> <p> <strong><span id="maxcitations">52</span> Citations: Showing <span id="showfrom">1</span> - <span id="showto">10</span> </strong> <br/><strong>Filter your results:</strong> </p> <div class="row"> <div class="col-sm-12"> <div class="citations_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper filter_select"> <select id="selSpecies" title="Species"> <option value="All">All Species</option> <option class="citation_filterRadio" value="species" data-filter="Human"> Human </option> <option class="citation_filterRadio" value="species" data-filter="Mouse"> Mouse </option> <option class="citation_filterRadio" value="species" data-filter="Rat"> Rat </option> <option class="citation_filterRadio" value="species" data-filter="Trypanosoma brucei"> Trypanosoma brucei </option> </select> </div> <div 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Cell"> Whole Cell </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cells"> Whole Cells </option> </select> </div> </div> </div> </div> <div class="row"> <ol id="citations" class="col-xs-12" data-expandall="false" data-max-citations="52" data-max-show="10"> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Organoid"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/38689717"> Integration of single-nucleus and exosome RNA sequencing dissected inter-cellular communication and biomarkers in pancreatic ductal adenocarcinoma </a> </span><br/> Authors: Tang, R;Zhang, Z;Xu, J;Wang, W;Meng, Q;Liu, Y;Du, Q;Liang, C;Hua, J;Zhang, B;Yu, X;Shi, S;<br/> Computational and structural biotechnology journal  2024-12-01 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Organoid"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/39169164"> Novel immunotherapeutics against LGR5 to target multiple cancer types </a> </span><br/> Authors: Chen, HC;Mueller, N;Stott, K;Kapeni, C;Rivers, E;Sauer, CM;Beke, F;Walsh, SJ;Ashman, N;O'Brien, L;Rafati Fard, A;Godsinia, A;Li, C;Joud, F;Giger, O;Zlobec, I;Olan, I;Aitken, SJ;Hoare, M;Mair, R;Serrao, E;Brenton, JD;Garcia-Gimenez, A;Richardson, SE;Huntly, B;Spring, DR;Skjoedt, MO;Skjødt, K;de la Roche, M;de la Roche, M;<br/> EMBO molecular medicine  2024-08-21 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Embryoid Bodies, Organoid"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/39095390"> Huntington's disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids </a> </span><br/> Authors: Galimberti, M;Nucera, MR;Bocchi, VD;Conforti, P;Vezzoli, E;Cereda, M;Maffezzini, C;Iennaco, R;Scolz, A;Falqui, A;Cordiglieri, C;Cremona, M;Espuny-Camacho, I;Faedo, A;Felsenfeld, DP;Vogt, TF;Ranzani, V;Zuccato, C;Besusso, D;Cattaneo, E;<br/> Nature communications  2024-08-02 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37749332"> Interaction between estrogen receptor-? and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women </a> </span><br/> Authors: Cherubini, A;Ostadreza, M;Jamialahmadi, O;Pelusi, S;Rrapaj, E;Casirati, E;Passignani, G;Norouziesfahani, M;Sinopoli, E;Baselli, G;Meda, C;Dongiovanni, P;Dondossola, D;Youngson, N;Tourna, A;Chokshi, S;Bugianesi, E;EPIDEMIC Study Investigators, ;Della Torre, S;Prati, D;Romeo, S;Valenti, L;<br/> Nature medicine  2023-09-25 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37173024"> Hyaluronic acid-based dual network hydrogel with sustained release of platelet-rich plasma as a diabetic wound dressing </a> </span><br/> Authors: Zhou, J;Liu, Y;Liu, X;Wan, J;Zuo, S;Pan, T;Liu, Y;Sun, F;Gao, M;Yu, X;Zhou, W;Xu, J;Zhou, Z;Wang, S;<br/> Carbohydrate polymers  2023-08-15 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37436981"> Reconstitution of morphogen shuttling circuits </a> </span><br/> Authors: Zhu, R;Santat, LA;Markson, JS;Nandagopal, N;Gregrowicz, J;Elowitz, MB;<br/> Science advances  2023-07-14 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37461708"> Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins </a> </span><br/> Authors: Blümke, A;Ijeoma, E;Simon, J;Wellington, R;Purwaningrum, M;Doulatov, S;Leber, E;Scatena, M;Giachelli, CM;<br/> Research square  2023-07-07 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="Bioassay" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37018875"> Direct comparison of [18F]AlF-NOTA-JR11 and [18F]AlF-NOTA-octreotide for PET imaging of neuroendocrine tumors: Antagonist versus agonist </a> </span><br/> Authors: S Ahenkorah, C Cawthorne, E Murce, CM Deroose, T Cardinaels, Y Seimbille, G Bormans, M Ooms, F Cleeren<br/> Nuclear medicine and biology, 2023-03-29;118(0):108338.  2023-03-29 <br/> </li> <li class="top-lined" data-species="Rat" data-application="Bioassay" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37095964"> VEGFA-modified DPSCs combined with LC-YE-PLGA NGCs promote facial nerve injury repair in rats </a> </span><br/> Authors: W Xu, X Xu, L Yao, B Xue, H Xi, X Cao, G Piao, S Lin, X Wang<br/> Heliyon, 2023-03-28;9(4):e14626.  2023-03-28 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/36316443"> Extracellular vesicles-transferred SBSN drives glioma aggressiveness by activating NF-kappaB via ANXA1-dependent ubiquitination of NEMO </a> </span><br/> Authors: H Chen, X Chen, Z Zhang, W Bao, Z Gao, D Li, X Xie, P Zhou, C Yang, Z Zhou, J Pan, X Kuang, R Tang, Z Feng, L Zhou, D Zhu, J Yang, L Wang, H Huang, D Tang, J Liu, L Jiang<br/> Oncogene, 2022-10-31;0(0):.  2022-10-31 <br/> </li> <div id="ds_extra_cits"> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Organoid"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/36123390"> YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma </a> </span><br/> Authors: W Yu, C Zhang, Y Wang, X Tian, Y Miao, F Meng, L Ma, X Zhang, J Xia<br/> Cancer Gene Therapy, 2022-09-19;0(0):.  2022-09-19 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Organoid"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/36085201"> Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors </a> </span><br/> Authors: EI Rivas, J Linares, M Zwick, A Gómez-Llon, M Guiu, A Labernadie, J Badia-Rame, A Lladó, L Bardia, I Pérez-Núñe, C Martínez-C, N Tarazona, A Sallent-Ar, M Garrido, T Celià-Terr, O Burgués, RR Gomis, J Albanell, A Calon<br/> Nature Communications, 2022-09-09;13(1):5310.  2022-09-09 <br/> </li> <li class="top-lined" data-species="Rat" data-application="Cell Culture" data-sampletype="Whole Cell"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35939689"> Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1 </a> </span><br/> Authors: MM Schwarz, DA Price, SS Ganaie, A Feng, N Mishra, RM Hoehl, F Fatma, SH Stubbs, SPJ Whelan, X Cui, T Egawa, DW Leung, GK Amarasingh, AL Hartman<br/> Proceedings of the National Academy of Sciences of the United States of America, 2022-08-08;119(33):e2204706119.  2022-08-08 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35113810"> Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation </a> </span><br/> Authors: MR Riccetti, MG Ushakumary, M Waltamath, J Green, J Snowball, SE Dautel, M Endale, B Lami, J Woods, SK Ahlfeld, AT Perl<br/> JCI Insight, 2022-03-08;0(0):.  2022-03-08 <br/> </li> <li class="top-lined" data-species="Rat" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35163379"> Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1alpha Delivery for Enhanced Angiogenesis in Tissue Engineering Applications </a> </span><br/> Authors: RN Power, BL Cavanagh, JE Dixon, CM Curtin, FJ O'Brien<br/> International Journal of Molecular Sciences, 2022-01-27;23(3):.  2022-01-27 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34073955"> Extracellular Matrix Components Regulate Bone Sialoprotein Expression in MDA-MB-231 Breast Cancer Cells </a> </span><br/> Authors: F Keller, R Bruch, F Clauder, M Hafner, R Rudolf<br/> Cells, 2021-05-24;10(6):.  2021-05-24 <br/> </li> <li class="top-lined" data-species="Trypanosoma brucei" data-application="" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33909626"> Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro </a> </span><br/> Authors: F Rojas, M Cayla, KR Matthews<br/> PloS Neglected Tropical Diseases, 2021-04-28;15(4):e0009284.  2021-04-28 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33592337"> Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production </a> </span><br/> Authors: PK Yang, CH Chou, CC Huang, WF Wen, HF Chen, CT Shun, HN Ho, MJ Chen<br/> Molecular Metabolism, 2021-02-13;49(0):101189.  2021-02-13 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/32674302"> Specific and Non-Invasive Fluorescent Labelling of Extracellular Vesicles for Evaluation of Intracellular Processing by Intestinal Epithelial Cells </a> </span><br/> Authors: MS Hansen, ISE Gadegaard, EC Arnspang, K Blans, LN Nejsum, JT Rasmussen<br/> Biomedicines, 2020-07-14;8(7):.  2020-07-14 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/32576280"> New generation breast cancer cell lines developed from patient-derived xenografts </a> </span><br/> Authors: J Finlay-Sch, BM Jacobsen, D Riley, KV Paul, S Turner, A Ferreira-G, JC Harrell, P Kabos, CA Sartorius<br/> Breast Cancer Res., 2020-06-23;22(1):68.  2020-06-23 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="Bioassay" data-sampletype="Protein"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/31181457"> Analysis of protein chlorination by mass spectrometry </a> </span><br/> Authors: T Nybo, MJ Davies, A Rogowska-W<br/> Redox Biol, 2019-06-01;26(0):101236.  2019-06-01 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/30859901"> Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation </a> </span><br/> Authors: BL Baechler, D Bloemberg, J Quadrilate<br/> Autophagy, 2019-04-07;0(0):.  2019-04-07 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28439967"> Involvement of the heparanase procoagulant domain in bleeding and wound healing. </a> </span><br/> Authors: Crispel Y, Ghanem S, Attias J, Kogan I, Brenner B, Nadir Y<br/> J Thromb Haemost, 2017-06-04;15(7):1463-1472.  2017-06-04 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28373172"> Mouse embryonic dorsal root ganglia contain pluripotent stem cells that show features similar to embryonic stem cells and induced pluripotent stem cells. </a> </span><br/> Authors: Ogawa R, Fujita K, Ito K<br/> Biol Open, 2017-05-15;6(5):602-618.  2017-05-15 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28414317"> p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function. </a> </span><br/> Authors: Sen M, Akeno N, Reece A, Miller A, Simpson D, Wikenheiser-Brokamp K<br/> Oncogenesis, 2017-04-17;6(4):e320.  2017-04-17 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28292941"> Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer. </a> </span><br/> Authors: Willuda J, Linden L, Lerchen H, Kopitz C, Stelte-Ludwig B, Pena C, Lange C, Golfier S, Kneip C, Carrigan P, McLean K, Schuhmacher J, von Ahsen O, Muller J, Dittmer F, Beier R, El Sheikh S, Tebbe J, Leder G, Apeler H, Jautelat R, Ziegelbauer K, Kreft B<br/> Mol Cancer Ther, 2017-03-14;16(5):893-904.  2017-03-14 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28235023"> Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns. </a> </span><br/> Authors: Stadem P, Hilgers M, Bengo D, Cusick S, Ndidde S, Slusher T, Lund T<br/> PLoS ONE, 2017-02-24;12(2):e0172980.  2017-02-24 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28235899"> Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior. </a> </span><br/> Authors: Jones B, Kelley L, Loskutov Y, Marinak K, Kozyreva V, Smolkin M, Pugacheva E<br/> Mol Cancer Res, 2017-02-24;15(6):670-682.  2017-02-24 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28011620"> Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells. </a> </span><br/> Authors: Binda E, Visioli A, Giani F, Trivieri N, Palumbo O, Restelli S, Dezi F, Mazza T, Fusilli C, Legnani F, Carella M, Di Meco F, Duggal R, Vescovi A<br/> Cancer Res, 2016-12-23;77(4):996-1007.  2016-12-23 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/27849608"> Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression </a> </span><br/> Proc. Natl. Acad. Sci. U.S.A., 2016-11-14;0(0):.  2016-11-14 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/27578003"> Wnt signaling promotes breast cancer by blocking ITCH-mediated degradation of the YAP/TAZ transcriptional coactivator WBP2 </a> </span><br/> Cancer Res, 2016-08-30;0(0):.  2016-08-30 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26538436"> Real-time monitoring of NKCC2 endocytosis by total internal reflection fluorescence (TIRF) microscopy. </a> </span><br/> Authors: Jaykumar A, Caceres P, Sablaban I, Tannous B, Ortiz P<br/> Am J Physiol Renal Physiol, 2015-11-04;310(2):F183-91.  2015-11-04 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26503968"> Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-beta-dependent activation of matrix metalloproteases. </a> </span><br/> Authors: Romero D, Al-Shareef Z, Gorrono-Etxebarria I, Atkins S, Turrell F, Chhetri J, Bengoa-Vergniory N, Zenzmaier C, Berger P, Waxman J, Kypta R<br/> Carcinogenesis, 2015-10-26;37(1):18-29.  2015-10-26 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26432786"> Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models. </a> </span><br/> Authors: Sameni M, Tovar E, Essenburg C, Chalasani A, Linklater E, Borgman A, Cherba D, Anbalagan A, Winn M, Graveel C, Sloane B<br/> Clin Cancer Res, 2015-10-02;22(4):923-34.  2015-10-02 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26431963"> MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. </a> </span><br/> Authors: Beke L, Kig C, Linders J, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson C, Beullens M, Brehmer D, Bollen M<br/> Biosci Rep, 2015-10-02;35(6):.  2015-10-02 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26403201"> The MEF2-HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro. </a> </span><br/> Authors: Clocchiatti A, Di Giorgio E, Viviani G, Streuli C, Sgorbissa A, Picco R, Cutano V, Brancolini C<br/> J Cell Sci, 2015-09-24;128(21):3961-76.  2015-09-24 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25432176"> PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells. </a> </span><br/> Authors: Kolev V, Wright Q, Vidal C, Ring J, Shapiro I, Ricono J, Weaver D, Padval M, Pachter J, Xu Q<br/> Cancer Res, 2014-11-28;75(2):446-55.  2014-11-28 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25100846"> The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland. </a> </span><br/> Authors: Bittencourt F, Wu S, Bridges J, Miller W<br/> J Virol, 2014-08-06;88(20):11811-24.  2014-08-06 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24898257"> The nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress. </a> </span><br/> Authors: Zhu B, Ferry C, Markell L, Blazanin N, Glick A, Gonzalez F, Peters J<br/> J Biol Chem, 2014-06-04;289(29):20102-19.  2014-06-04 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24623414"> Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth. </a> </span><br/> Authors: Caccuri, Francesc, Giagulli, Cinzia, Reichelt, Joachim, Martorelli, Debora, Marsico, Stefania, Bugatti, Antonell, Barone, Ines, Rusnati, Marco, Guzman, Carlos A, Dolcetti, Riccardo, Caruso, Arnaldo<br/> J Virol, 2014-03-12;88(10):5706-17.  2014-03-12 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24552775"> Inhibition of tumor growth and angiogenesis by SP-2, an anti-lectin, galactoside-binding soluble 3 binding protein (LGALS3BP) antibody. </a> </span><br/> Authors: Traini S, Piccolo E, Tinari N, Rossi C, La Sorda R, Spinella F, Bagnato A, Lattanzio R, D'Egidio M, Di Risio A, Tomao F, Grassadonia A, Piantelli M, Natoli C, Iacobelli S<br/> Mol Cancer Ther, 2014-02-19;13(4):916-25.  2014-02-19 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24473118"> The interplay between hypoxia, endothelial and melanoma cells regulates vascularization and cell motility through endothelin-1 and vascular endothelial growth factor. </a> </span><br/> Authors: Spinella F, Caprara V, Cianfrocca R, Rosano L, Di Castro V, Garrafa E, Natali P, Bagnato A<br/> Carcinogenesis, 2014-01-28;35(4):840-8.  2014-01-28 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24148819"> Suppression of ERbeta signaling via ERbeta knockout or antagonist protects against bladder cancer development. </a> </span><br/> Authors: Hsu I, Chuang K, Slavin S, Da J, Lim W, Pang S, O'Brien J, Yeh S<br/> Carcinogenesis, 2013-10-22;35(3):651-61.  2013-10-22 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23293332"> Regulation of P21-activated kinase-4 by progesterone and tumor necrosis factor-alpha in human endometrium and its increased expression in advanced-stage endometriosis. </a> </span><br/> Authors: Kim S, Kim S, Ihm H, Oh Y, Chae H, Kim C, Kang B<br/> J Clin Endocrinol Metab, 2013-01-04;98(2):E238-48.  2013-01-04 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23112172"> Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells. </a> </span><br/> Authors: Zhang W, Kai K, Choi D, Iwamoto T, Nguyen Y, Wong H, Landis M, Ueno N, Chang J, Qin L<br/> Proc Natl Acad Sci U S A, 2012-10-29;109(46):18707-12.  2012-10-29 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22923784"> Translation of a tumor microenvironment mimicking 3D tumor growth co-culture assay platform to high-content screening. </a> </span><br/> Authors: Krausz E, de Hoogt R, Gustin E, Cornelissen F, Grand-Perret T, Janssen L, Vloemans N, Wuyts D, Frans S, Axel A, Peeters P, Hall B, Cik M<br/> J Biomol Screen, 2012-08-24;18(1):54-66.  2012-08-24 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22904195"> HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2. </a> </span><br/> Authors: Caccuri F, Giagulli C, Bugatti A, Benetti A, Alessandri G, Ribatti D, Marsico S, Apostoli P, Slevin M, Rusnati M, Guzman C, Fiorentini S, Caruso A<br/> Proc Natl Acad Sci U S A, 2012-08-17;109(36):14580-5.  2012-08-17 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22879538"> A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment. </a> </span><br/> Authors: Zhang W, Dang S, Hong T, Tang J, Fan J, Bu D, Sun Y, Wang Z, Wisniewski T<br/> Blood, 2012-08-09;120(14):2889-98.  2012-08-09 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22461640"> Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. </a> </span><br/> Authors: Munson J, Fried L, Rowson S, Bonner M, Karumbaiah L, Diaz B, Courtneidge S, Knaus U, Brat D, Arbiser J, Bellamkonda R<br/> Sci Transl Med, 2012-03-28;4(127):127ra36.  2012-03-28 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22379025"> Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2. </a> </span><br/> Authors: Cieply B, Riley P, Pifer P, Widmeyer J, Addison J, Ivanov A, Denvir J, Frisch S<br/> Cancer Res, 2012-02-29;72(9):2440-53.  2012-02-29 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22266111"> Cathepsin B inhibition limits bone metastasis in breast cancer. </a> </span><br/> Authors: Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, Bidwell B, Edgington L, Wang L, Moin K, Sloane B, Anderson R, Bogyo M, Parker B<br/> Cancer Res, 2012-01-19;72(5):1199-209.  2012-01-19 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/2842065"> Timing and targeting: the biological functions of Dam methylation in E. coli. </a> </span><br/> Authors: Messer W, Noyer-Weidner M<br/> Cell, 1988-09-09;54(6):735-7.  1988-09-09 <br/> </li> </div> </ol> </div> <div class="clearfix"><button class="btn btn-quinary ds_extra_cits pull-right toggle_cits_down" id="toggle_cits"></button></div> </div> </div>  <div class="tab_content tab_4" data-tab="4" data-tabname="product-faqs" id="product-faqs"> <h2>FAQs</h2> <div class="row"> <div class="col-xs-12"> <ol id="faq_list"> <li> <span class="faq_question"><p>What kinds of tumor cells or biopsy specimens grow <em>in vivo </em>with Cultrex® BME?</p></span> <ul class="faq_answer"> <li><p>Many cell lines and tumor biopsy specimens (usually cut into small fragments) have been found to grow <em>in vivo</em> when implanted with Cultrex<sup>®</sup> BME. These include melanoma, intestinal, prostate, breast, lung, renal, and liver cancers as well as the 3T3 mouse embryonic fibroblast cell line.</p></li> </ul> </li> <li> <span class="faq_question"><p>How does Cultrex<sup>®</sup> Basement Membrane Extract (BME) promote cell differentiation?</p></span> <ul class="faq_answer"> <li><p>All epithelial and endothelial cells are in contact with a basement membrane matrix on at least one of their surfaces. By providing them with their natural matrix <em>in vitro</em> as a substrate for the cells that provides biological cues, the cells can assume a more physiological morphology (i.e. correct shape) and begin expression of cell-lineage specific proteins. Two-dimensional plastic surfaces, in combination with serum-containing media, cause cells to flatten, proliferate and de-differentiate.</p></li> </ul> </li> <li> <span class="faq_question"><p>How should Cultrex Basement Membrane Extract (BME) be stored and handled?</p></span> <ul class="faq_answer"> <li><p>For best practices for handling our BME products, please refer to our helpful guide at the following link: <a href="https://www.bio-techne.com/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/cell-culture-matrix-for-your-research">https://www.bio-techne.com/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/cell-culture-matrix-for-your-research</a></p></li> </ul> </li> <li> <span class="faq_question"><p>What is the percent of Laminin I in Cultrex® Basement Membrane Extract, PathClear, Catalog # 3432-010-01?</p></span> <ul class="faq_answer"> <li><p>Cultrex® Basement Membrane Extract (BME), Pathclear, is composed of ≤ 60 % of Laminin I. Laminin is the major component of Cultrex BME. Other components are Collagen IV, which makes up ≤ 40% and Entactin which makes up ≤ 10%.</p></li> </ul> </li> </ol> <a class="btn btn-quinary view_all_faqs_btn" href="/resources/faqs/"> View all FAQs </a> </div> </div> </div>   <div class="tab_content tab_6" data-tab="6" data-tabname="product-reviews" id="reviews"> <h3>Reviews for Cultrex Basement Membrane Extract, PathClear</h3> <div class="row"> <div class="col-xs-12"> <div class="datasheet_section"> <div class="row"> <div class="col-md-6"> <p> Average Rating: 4.9 <span class="review_stars_5"></span> (Based on 9 Reviews) </p> <div class="review_rating_progress"> <div class="row"> <div class="col-xs-3"> 5 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="88.888888888889" aria-valuemin="0" aria-valuemax="100" style="width:88.888888888889%"> </div> </div> </div> <div class="col-xs-3"> 88.89% </div> </div> <div class="row"> <div class="col-xs-3"> 4 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="11.111111111111" aria-valuemin="0" aria-valuemax="100" style="width:11.111111111111%"> </div> </div> </div> <div class="col-xs-3"> 11.11% </div> </div> <div class="row"> <div class="col-xs-3"> 3 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 2 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 1 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> </div> </div> <div class="col-md-6"> <div class="well"> <h4>Have you used Cultrex Basement Membrane Extract, PathClear?</h4> <h5><strong>Submit a review and receive an Amazon gift card.</strong></h5> <div class="review_reward_txt"> <p>$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image</p> <p>$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image</p> </div> <a class="btn btn-quinary" href="/reviews/3432-010-01"> Submit a Review </a> </div> </div> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <div class="reviews_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper"> <select class="review_filter_rating"> <option value="all">All Ratings</option> <option value="5">5</option> <option value="4">4</option> </select> </div> <div class="select_wrapper"> <select class="review_filter_application"> <option value="all">All Applications</option> <option value="In vivo study"> In vivo study </option> <option value="Cell migration/motility"> Cell migration/motility </option> <option value="Cell Proliferation"> Cell Proliferation </option> </select> </div> </div> </div> </div> <br/> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Cultrex Basement Membrane Extract, PathClear</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 10/16/2023 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_79971.jpg" data-title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Cultrex Basement Membrane Extract, PathClear 3432-010-01" title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_79971.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Cultrex Basement Membrane Extract, PathClear</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 05/25/2023 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_78536.jpg" data-title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Cultrex Basement Membrane Extract, PathClear 3432-010-01" title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_78536.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Cultrex Basement Membrane Extract, PathClear</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 05/15/2023 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_78176.jpg" data-title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Cultrex Basement Membrane Extract, PathClear 3432-010-01" title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_78176.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Cultrex Basement Membrane Extract, PathClear</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 11/06/2022 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_75786.jpg" data-title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Cultrex Basement Membrane Extract, PathClear 3432-010-01" title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_75786.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Cultrex Basement Membrane Extract, PathClear</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 05/23/2022 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> <div class="review_how_used"><p>Used for 3D culture experiments. Went very well</p></div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_72921_0.jpg" data-title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Cultrex Basement Membrane Extract, PathClear 3432-010-01" title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_72921_0.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="4" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_4">Cultrex Basement Membrane Extract, PathClear</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 02/01/2022 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> <div class="review_how_used"><p>for 3D cell culture</p></div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_70731_0.jpg" data-title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Cultrex Basement Membrane Extract, PathClear 3432-010-01" title="Cultrex Basement Membrane Extract, PathClear 3432-010-01" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_3432-010-01_70731_0.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application="In vivo study"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Cultrex PathClear Basement Membrane Extract (2 x 5 mL)</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 08/20/2018 </div> <div class="row"> <div class="review_specifics col-xs-12"> <span class="ds_review_data"> <strong>Application:</strong> In vivo study </span> </div> </div> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application="Cell migration/motility"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Cultrex PathClear Basement Membrane Extract</div> <div class="review_date">By <span class="review_reviewer">Leslie Priddy</span> on 04/01/2018 </div> <div class="row"> <div class="review_specifics col-xs-12"> <span class="ds_review_data"> <strong>Application:</strong> Cell migration/motility </span> </div> </div> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application="Cell Proliferation"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Cultrex PathClear Basement Membrane Extract</div> <div class="review_date">By 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