CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "conbio.onlinelibrary.wiley.com",cType: 'managed',cRay: '8e93a6966c333f5e',cH: 'HQVk7zPO6i5sJo82hzoQiHa8Er_kxiRs6C9jFl4alV0-1732726577-1.2.1.1-ubWKfLjk5QxzAyWQkGZtFSAkVeA17h99ASG8IOtXxELJsbTG1Iw.aGtJxZ32HJeV',cUPMDTk: "\/journal\/1755263x?__cf_chl_tk=3msw8ObaVgdqqXkyhRgjgiwJ2Z1WwwUSLm0ynCvVMu0-1732726577-1.0.1.1-6.mwb.3LeRcGGVaCnvYLPXij3wj0gulzQRzY3yDQj.4",cFPWv: 'b',cITimeS: '1732726577',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/journal\/1755263x?__cf_chl_f_tk=3msw8ObaVgdqqXkyhRgjgiwJ2Z1WwwUSLm0ynCvVMu0-1732726577-1.0.1.1-6.mwb.3LeRcGGVaCnvYLPXij3wj0gulzQRzY3yDQj.4",md: "v5jY7jFVEJCnRh.uF5XfkoXL8kaf4DNyrpLJDOKttls-1732726577-1.2.1.1-Z1qIUw9MUUnf8qzDhU21us_q84ykxjtmnpAESGqal_58AGTXzXlzNQOWahkn4vZ8UOX3oCLLqHm6NQZtDdmPC8bT3t6Rjm5WbfEau3AcyJ5yN3eA7EkgPCqqF9CCthBwhi166K3XeRtvNsDJsvrFr4VQBl68AIcUCuFl.TBmnbJFsF.xYVgwhcj2Ilxx.zPGDfp7npgTHScKCOzAZ57AsLpOw0AoJhLbNt4xdBfGd.aM2Ax5N5go0DzI1QTjBHpgSMlZEWd_Q1cLWc301qIU8CzTaPadX2hap.x35j087_1fmR_N67S7MISrrsJZ3v2TiEkku95UGJIJlQrQ.ymGdXjIzPnIDlRij7lxH3WXGLt8RnvGEqNZfavJr0Qgrrtzvb0_d9pAbjgJXLkxelTCBllFWWYd5UF5j3C1FKu_vNRy0pwFqMkCEXwop9pHiho7dHE6mRxonwG5a0ftgzjTjH7f5T6ePO03OTHCWz1kQImJR9e8pgNhzyeh50Myr2oLdetjE7TUYqUj3o17SVfoAY2JXqqHRm9IJzVTVqesD.Yef9GS1ZcomBHNjTk_MLV0KRNF7OJ5T42VSD0DiYyoQ7I.aIPn_HJqZU6M4cIOS4hs13DijJsnaSKfXBA6yeFJ52TH79Z8.7PTBNQjM3ficHFC_qVJ49dy.lJhAe6jVmN86R7VOi_bOfNe6IWr1WtTPxB4aRjtiarCmB6525qPjy2JHVcxoT_QOauktYFpNi1j51CKiHc0lFz4mJHvnsYFEipy8Muc4pcUQDbBZEArztYifwXj_Zr7ZcaAYFu5KvVNY95Ukn1w4m..moDeDo0MRhrvUCM3KQijscP4ZeRR3g3OJYLlj7YeH.LShqnZuZwslRuqfM92kFqvtJpnbeUgp627BIcryJWhgEdn5Tj4EexYdunPtisl6MCnYpXNof9zTkqmVlQOOkyOE.z_DsenGliLFT7_LOHpDlg1jCKMv6Not7elopzz5Sc7nDgbvJsyV046zJ0QEa.0gFXFaLrGPaKR3nJWDsqUf3CxD.ds73fh0GFFjbaYqUKX56GrWudgaRVgsax5mhWghkDwmbzKYRvHrkrs33CtZU_HV.omnhTHUJfjHVePVWWnsNO.mB4kyfCSJh26fVTyAu9Mz.V7knBMJrgbyXoLe192Z4FnSjrMYLksgjTjdj4oGzkXLGzn5PBJGd.k9xrnPpp4vUgTGef9jWe1Igmj3_ZhVJoThfYViN.YTEIybiq.yW5noVtfd5mA1wiOqxK8QMaTXINmcRYyr4e3eKV5q_IBB57PPnrZXP7Y.bGsv7o6gIN.hL5ix3uMzZ4Al_scd70CW8Z8WsW26BVdF3mHs1J81c4IKB0fqXe54F1dydjCyk8EuoccpPRc658gkoci_TQSb0CBh1QH5x5zGMIKsGTXzLm_FiOaBrR5m6RA_ZiTkpdDRkT0LryF7Rsv9GEYDMJhxxZM7hfhSF._gHa.7ZAkTZxlyTacH2EXiEBX5USCYRa0wBHxlez_esJjc5pbbOm.vC2wzvGJimC28QuHpaRqPd2oMEesDKbRVV1FUidH8gnWxwurPCFIVo5EhuPpNHzcbyMgKpoirZd4kLSSKJU.Wj2OYxlt8bmUBJQ45_yf.2Ivgey7vqjNSG3QB1Du0FMKNiUfl4eMhOKDzO4UDyE.sxlJMLAo9sYvJc6EX8pLg0D3iIyMf.1TUI3Th6tA7CG9JB2Alwcsckr26NRnKwP0X18qAKp86nzmo50_6Ij5i2YcnuuCuwhAsT26M0ATwGceGSNCbIz5zR6JMtoK9jU_5xt_ZVuQhPsbO2RkGTdOiT9YTn1W5ZhtoorJfLVp1mvihPeHaVRt8jVAwlCAyDCNU4wGcpst58VrM4tXk_IxQQR92aAbTj3UGPF4z41va6hyDDa9XQbeMnauLE.otml6OGFy2KJEkNRsYv1vLHHpFUVEggk23wIl_RYaKBWCYVGb8gOOFZEZ2Wzk6YPmAgAzKHNn_TUNzTU47VoVscpanCF9pPiBzLLVqhVllAQbFdhKL67HXrmECo3UlGXsqgDHwbwVeRS90QnP61701bM_P8wTCsUSGAJub.0le0PPl9nNQFWsDYDFq1XpTAwTUIn3faiZSYB5R9I6F6rWAmPux98CW.rg.Lb9CEfACpVQVE1xzpIw_g2WaJvi2H2yZLh5OA_eQIP4Jp.l6NoPM_BotpDBcmWZ4N.hWDnWRA8cRbwaB21zE04OLweDutevrFZLa6fU.wb9kBwUHrUSNDS0AGXJxubitgYmWVpyUhFK3c2uYuSjvmgnVTeLIRiuAQzQCupmpjp5pdvWb6DkjMQ1ZSqqRw9FtoG9aQeD0p0kTf9vKvrAXvG._0EKo_d_N.tMLFLOn6CDtDMnU.rpbTSy9EPXc7lcW.hkUeCqN47p4xu8wmI9noHKrzlwjO.6zlse9EVjD3mI1hGpslaotyEDY04lr1sHe7cFku3HDTG4_oo1nJf_0Ab8NtHyBCXHD9Z991cCnixH3v07b8ZuwBWlzyvTsY.d.aT.6pgyD8782yeNEHdrwZ_WsG1lCR6VWmShBcTEfp1M3PafPEx6TZoW2CGQuzPWC_PY3u3PGsai2U.bXuLQDp.idO6mj_1fY_9qYIcucVcoQMEeaJAIiRuCSMJ3EpW03pMMvt89WHYJmZaDPf6UOVmWA9XQugpA1o98_jgcLrWaiUWwNKbTyvqPMzXEZfI9gHeKWVV6U7Soq8_OTovABf2Y6bDkujLsjyp2O9HBVil5ScbEH74xbyMJvyoyeYM1TztG6cOCaSo2mkw8VbzZUCmcFBvSxAo3leW3wbqeDsqfVPg_XrzGLbwfwSpjkdycCqiSCg85kUy2mjTx_HkcG5AUk76vSjDgMjtLEN4_992pB8F158dQPwcBEgFKHArC7QDy5zYyC.ScUrXB_DpA.FaqftSyXRivcprLMV7VD9gWMVGcQYn.ABEAFIfX69c",mdrd: "L1k06QPBPn8xGS51T7yAg1Hp4OKVZWcimJ6Rf7_GuEY-1732726577-1.2.1.1-kRVBFBSz_c7RRxoUFDohwCbYHYnl8JsTs2Od2fA39SeimFs7OppTaWvT7WMRCFpW1LhaI.VdCpDRQMgsL.ISJ8hj9hxmPe0SD5a6k78hfcNACE_7E_A34piq4dQZ8anPVTaX4Ms9LAQZdEOixsRP6DqGXllhX8xiehc2Jm3X86IghGszePRNyB3li2rW49ZTjdKvgImhptrCfmKrM7yY3QBacxCYVQKRF1mVZjLW9IO4X5RcH52_Wf7i4oZskw0KWYL1w2Hi16xQwFiDZqzal7r7kGi3QQn4wmNlrvjHLAqa4dfmo6PM0jGkm5vWySehzgAXh45RzBXcojVASy1sRh01vZ7bsqPzDy5wDJRkY_4NLvO2OVNrctWUoBdISnY0RfQOXnKUc6CjAOFblERf5XUmwzmQ31NyNqrTEmS8NdcTpajX9gChh6Hvv_rD44_8TZqZX8ezdbA5CccmKHz4AFlzDFKgUybEaly8V9DUq6RO1RMUaw.vrZtCInIS3P57Ljt_NpHWuU9ZCWYpz6A55dJJ6wDtudJjM2lQzlmHaflJD5oq11fh7NACGxPPwIqGnLYC_riiUqrAjL06ykK2NrbyzE3F.W.2M4u2Nn7hZTQfGR7M90BQ5NR51Bb34jkkkCcIdFxiga82NoEfT3rnDy8c59npEvHp3rO7TAJDTrymO6TAosjwsiT1TQPxT9eBDzSIOKWZ48ccsSd0LbjkEpyYp9o2mslhdoD7N70zsipY5jJP_Akd2wUUeiZkm31UE11hH.vu0_u_JE_DhBS7wfC8Z1dBafjyqoGZ4Eh7.wrOWmPA47rFgwJA.F3gOnbvVrxemZ0_K_1p9kxHXqnTKAxCqswbtNlGnuMCI1O9JdWZl2M34tlhArZpnzCJHRmbk9kn0NWrCIlbxzVPdNIKGTfwWPZSdb6f0t.xV6rUL3oo3RXAvCXOTRoRwOpDOMx0E2dR9QpglJ2aBiZgtiwF82tF4Yn4jBhtJ7pzKST537YJIOC4BEqEF8MxfSex76GEwpNUG_HYHZL75g4x0BqknkKYR5wIH35Ec5sGo_tk8ltzumkHuyOWUVB70OMv0i66qBXYgGarreRdTX1.DDn4MPoU9T5l3UBsfKqNA6TtjZKaBW3NA9vz6v..QKrvYGK9oZUwwA4UKfOH9rHK1niE7QlrXFHyOWWL4dZYcgR2LoIpFv4j.DZe8EQpZPjKK8Z8E4s0bRc2XnYhMAIu7WazzNT8AHpuv6wkRz_nf7GxHvvxOQPOMYyPaBVF0kiVK3F_NUNks0zUkveNkI.C7JmSR_rk.uKkG_0HqrY5H50DIVGiviHNh7cFw.4MwyKkbYNaA3FvZB0NbckaFi1z0KpMDpudLjXZxelScA9xI_qIiHgP_b22pIe5ltG6HFFxb2.FQJkD0vWHzEinRuuC5vj2Ov4DLhp1InVbuNBXoy02E6NFAyqef83yAPgMDgO2CLl2YrSM_SxaelaN8JcfEmrZrjj066tH9g3YJXFMRnF6AFSx0PSEwy4At4kTzQav2xVRzaY2Yw2agLZS2P1y7i2dM9O_fwlAJ2aJvMrmYj.60z0OVfUFagr3OhXHIcT.LdGDI2uJHVeiFgpOJ6.ez9HaEEo0Rs6Z1iC6wIkVnMl0WUWY9C9kNBcFIZSAdFAvxq8XDGmrdwIZE0aYa9KcnwZrJogaVQUC8IlhnfMAmJxmxgX1nznm0RR0P59JTCgfyHblDBCVMzy9IAKCMh42klnDOY.bLy6qQtDtbN8RNd7bpieH66r8uDtLCYjh7gxkUbCR7qRp8ORUfKF1jkauSpqHXDhyB3DdtonF09ysEg.AD3DbfNQIT6CFCufA4neWtpwJLlEoBbgSj05lEhy7dkascdEILQlNvP1WNGGL7yzrOYnK4kj9I1nNlcoEDdJo8RcTcTjpJ3bULPUSmBMudnqmlRWoDexyh1onuT._P.CDFu3S6dQd2_aHmtGnJZKNATecMoDgt9R5tquiNH9LBkG0U1XAv7s3hyBo5Om5v9ZW5RI"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8e93a6966c333f5e';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/journal\/1755263x?__cf_chl_rt_tk=3msw8ObaVgdqqXkyhRgjgiwJ2Z1WwwUSLm0ynCvVMu0-1732726577-1.0.1.1-6.mwb.3LeRcGGVaCnvYLPXij3wj0gulzQRzY3yDQj.4" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>