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Neurath</span></a><ul id="navlist1022372" class="navbar__list collapse "><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/about-the-lab/" class="navbar__link " title="About the lab"><span>About the lab</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/projects/" class="navbar__link " title="Projects"><span>Projects</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/funding/" class="navbar__link " title="Funding"><span>Funding</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/lab-members/" class="navbar__link " title="Lab Members"><span>Lab Members</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/open-positions/" class="navbar__link " title="Open Positions"><span>Open Positions</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/protocols/" 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href="https://www.uk-erlangen.de/" title="Zur Startseite des Universit盲tsklinikums Erlangen"><svg height="37" xmlns="http://www.w3.org/2000/svg" viewBox="0,0,63,64"><g><path d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" opacity="1" fill="#00a579"/><path d="M41.876+21.0438L20.938+21.0438L20.938+42.3789L41.876+42.3789L41.876+21.0438Z" opacity="1" fill="#2761ab"/><path d="M41.876+42.3788L20.938+42.3788L20.938+63.7138L41.876+63.7138L41.876+42.3788Z" opacity="1" fill="#00B1EB"/><path d="M41.876-0.29126L20.938-0.29126L20.938+21.0451L41.876+21.0451L41.876-0.29126Z" opacity="1" fill="#00B1EB"/></g></svg></a></li><li class="breadcrumb-item icon-arrow_right"><a class="breadcrumb-link" href="/" title="Medizin 1"><span class="breadcrumb-text">Medizin 1</span></a></li><li class="breadcrumb-item icon-arrow_right "><a class="breadcrumb-link" href="/forschung/" title="Forschung"><span class="breadcrumb-text">Forschung</span></a></li><li class="breadcrumb-item icon-arrow_right active" aria-current="page"><span class="breadcrumb-text">SFB Transregio 241</span></li></ol></div></nav><main id="page-content" class="bp-page-content main-section"><div class="section section-before-content"></div><div class="section section-default"><div id="c65260" class=" frame frame-default frame-type-textpic frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="textpic textpic-right imageorient-25"><div class="textpic-item textpic-gallery"><div class="gallery-row"><div class="gallery-item gallery-item-size-1"><div class="image-wrap"><figure class="image"><div class="position-relative"><picture class=""><source data-variant="default" data-maxwidth="765" media="(min-width: 1600px)" srcset="/fileadmin/_processed_/7/c/csm_IEC_Bildmarke_200mm_82dd261d0b.jpg 1x"><source data-variant="xlarge" data-maxwidth="595" media="(min-width: 1400px)" srcset="/fileadmin/_processed_/7/c/csm_IEC_Bildmarke_200mm_93907b96e5.jpg 1x"><source data-variant="large" data-maxwidth="595" media="(min-width: 1260px)" srcset="/fileadmin/_processed_/7/c/csm_IEC_Bildmarke_200mm_93907b96e5.jpg 1x"><source data-variant="medium" data-maxwidth="477" media="(min-width: 1024px)" srcset="/fileadmin/_processed_/7/c/csm_IEC_Bildmarke_200mm_479ef8ec76.jpg 1x"><source data-variant="small" data-maxwidth="690" media="(min-width: 720px)" srcset="/fileadmin/_processed_/7/c/csm_IEC_Bildmarke_200mm_5282b64ea6.jpg 1x"><source data-variant="extrasmall" data-maxwidth="690" srcset="/fileadmin/_processed_/7/c/csm_IEC_Bildmarke_200mm_5282b64ea6.jpg 1x"><img class="img-fluid" loading="lazy" src="/fileadmin/_processed_/7/c/csm_IEC_Bildmarke_200mm_56ab13aa73.jpg" width="765" height="348" title="" alt=""></picture></div></figure></div></div></div></div><div class="textpic-item textpic-text"><div class="frame-header"><h2 class="element-header "><span>Collaborative Research Center TRR241</span></h2></div><h2><strong>Immune Epithelial Crosstalk in Inflammatory Bowel Diseases</strong></h2></div></div></div></div></div></div></div><div id="c65261" class=" frame frame-default frame-type-textpic frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="textpic textpic-right imageorient-25"><div class="textpic-item textpic-gallery"></div><div class="textpic-item textpic-text"><p>Chronisch entz眉ndliche Darmerkrankungen (CED: Morbus Crohn, Colitis Ulcerosa) sind durch immer wiederkehrende chronische Entz眉ndungen im Magen-Darm-Trakt gekennzeichnet. Aufgrund der zunehmenden H盲ufigkeit beider Krankheiten und deren sch盲digenden Eigenschaften, besteht eine dringende Notwendigkeit, neue Erkenntnisse in der Pathophysiologie beider Erkrankungen zu erlangen, die dazu beitragen neue und innovative Therapieans盲tze zu entwickeln. Bisweilen ist die Ursachenforschung zur Krankheitsentstehung noch sehr l眉ckenhaft. Besonders im Hinblick auf die lokalen Interaktionen zwischen den Zellen gibt es viele offene Fragen. Der TRR241 ist eine gemeinsame Initiative zwischen Erlangen, Berlin und Kiel und macht es sich zur Aufgabe neu erworbenes Wissen 眉ber die mukosale Immunregulation und den Schutz der Epithelbarriere in ein neues Konzept zu integrieren. Ziel dieses Konzepts ist es, ein besseres Verst盲ndnis der Kommunikation zwischen Immunzellen und dem Epithel im CED Krankheitsverlauf zu erlangen.</p><p>Die grundlegende Hypothese unserer Initiative ist, das fehlgeleitete Signale zwischen dem Epithel und den Immunzellen zur Entstehung von chronisch entz眉ndlichen Darmerkrankungen beitragen. Wir sind voller Zuversicht, dass wir mit Hilfe unserer spezialisierten und multimodalen Anwendungen die zugrundeliegenden Prozesse zwischen Immunzellen und Epithel erforschen k枚nnen und dass aus diesen Erkenntnissen spezifische und innovative Strategien entstehen, um CED Erkrankungen entgegenzuwirken. Dieser Sonderforschungsbereich (SFB) vereint 盲u脽ert erfahrene Wissenschaftler aus der Gastroenterologie, Immunologie, Zellbiologie und Molekularbiologie. Durch den Zusammenschluss dieser Wissenschaftler vereinen wir die fachliche Expertise auf den Gebieten der experimentellen, translationalen und klinisch-orientierten Forschung. Durch die fachliche Kompetenz aller Beteiligten wollen wir gew盲hrleisten, die von uns gesteckten Ziele zu erreichen. Das Forschungsprogramm des SFB beinhaltet nicht nur die Erweiterung der Grundlagenforschung zur CED Entstehung, wir m枚chten auch eine einzigartige Plattform f眉r translationale Studien, wie auch pr盲klinische und klinische Studien anbieten. Die Forschungsarbeiten in Erlangen, Berlin und Kiel werden durch die Verwendung modernster Techniken gest眉tzt, wie zum Beispiel <em>In Vivo</em> Imaging, Next Generation Sequencing, intestinale Organoid Technologie und Molekular Imaging.</p><p><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%28Erlangen+OR+Kiel+OR+Berlin%29+AND+%28Triantafyllopoulou+A%5BAuthor+-+Last%5D+OR+Diefenbach+A%5BAuthor+-+Last%5D+OR+G%C3%BCnther+C%5BAuthor+-+Last%5D+OR+Becker+C%5BAuthor+-+Last%5D+OR+Wirtz+S%5BAuthor+-+Last%5D+OR+Hegazy+AN%5BAuthor+-+Last%5D+OR+St%C3%BCrzl+M+%5BAuthor+-+Last%5D+OR+Britzen-Laurent+N%5BAuthor+-+Last%5D+OR+Lopez-Posadas+R%5BAuthor+-+Last%5D+OR+Atreya+I%5BAuthor+-+Last%5D+OR+Hildner+K%5BAuthor+-+Last%5D+OR+Neufert+C%5BAuthor+-+Last%5D+OR+Siegmund+B%5BAuthor+-+Last%5D+OR+Weidinger+C%5BAuthor+-+Last%5D+OR+Romagnani+C%5BAuthor+-+Last%5D+OR+Ludwig+LSH%5BAuthor+-+Last%5D+OR+Sanders+A%5BAuthor+-+Last%5D+OR+Chang+HD%5BAuthor+-+Last%5D+OR+Ronchi+F%5BAuthor+-+Last%5D+OR+Leppkes+M%5BAuthor+-+Last%5D+OR+Scheibe+K%5BAuthor+-+Last%5D+OR+Patankar+JV%5BAuthor+-+Last%5D+OR+Klose+CSN%5BAuthor+-+Last%5D+OR+Krug+SM%5BAuthor+-+Last%5D+OR+Schulzke+JD%5BAuthor+-+Last%5D+OR+Bacher+P%5BAuthor+-+Last%5D+OR+Scheffold+A%5BAuthor+-+Last%5D+OR+Zundler+S%5BAuthor+-+Last%5D+OR+Sch%C3%BCrmann+S%5BAuthor+-+Last%5D+OR+Waldner+M%5BAuthor+-+Last%5D+OR+Atreya+R%5BAuthor+-+Last%5D+OR+Bojarski+C%5BAuthor+-+Last%5D+OR+Pr%C3%BCss+M%5BAuthor+-+Last%5D+OR+Schumann+M%5BAuthor+-+Last%5D+OR+Neurath+MF%5BAuthor+-+Last%5D+OR+Bosch-Voskens+C%5BAuthor+-+Last%5D+OR+Trajanoski+Z%5BAuthor+-+Last%5D+OR+K%C3%BChl+A%5BAuthor+-+Last%5D%29&sort=date" target="_blank" class="link link-external" title="Publikationen TRR - 241" rel="noreferrer">Publikationen </a></p><p>Mehr Informationen: <a href="http://www.transregio241.com" target="_blank" class="link link-external" rel="noreferrer">www.transregio241.de</a></p></div></div></div></div></div></div></div><div id="c90231" class=" frame frame-default frame-type-list frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>Forschungskoordination</span></h3></div><div class="result-list-items contact-items result-list-items-glossar columnsCount2"><div class="result-list-item result-list-item-image"><div class="list-item-image"><div class="image-wrap contact-image ratio ratio-1x1"><a title="脰ffnet die Visitenkarte von Prof. Dr. rer. nat. 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