Search results for: Z. Tomkov谩

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Tomkov谩"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Z. 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Tomkov谩"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Z. Tomkov谩</h1> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Hormones and Mineral Elements Associated with Osteoporosis in Postmenopausal Women in Eastern Slovakia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=M.%20Mydl%C3%A1rov%C3%A1%20Bla%C5%A1%C4%8D%C3%A1kov%C3%A1">M. Mydl谩rov谩 Bla拧膷谩kov谩</a>, <a href="https://publications.waset.org/search?q=J.%20Por%C3%A1%C4%8Dov%C3%A1"> J. Por谩膷ov谩</a>, <a href="https://publications.waset.org/search?q=Z.%20Tomkov%C3%A1"> Z. Tomkov谩</a>, <a href="https://publications.waset.org/search?q=%C4%BD.%20Bla%C5%A1%C4%8D%C3%A1kov%C3%A1"> 慕. Bla拧膷谩kov谩</a>, <a href="https://publications.waset.org/search?q=M.%20Nagy"> M. Nagy</a>, <a href="https://publications.waset.org/search?q=M.%20Kone%C4%8Dn%C3%A1"> M. Kone膷n谩</a>, <a href="https://publications.waset.org/search?q=E.%20Petrej%C4%8D%C3%ADkov%C3%A1"> E. Petrej膷铆kov谩</a>, <a href="https://publications.waset.org/search?q=Z.%20Goga%C4%BEov%C3%A1"> Z. Goga木ov谩</a>, <a href="https://publications.waset.org/search?q=V.%20Sedl%C3%A1k"> V. Sedl谩k</a>, <a href="https://publications.waset.org/search?q=J.%20Mydl%C3%A1r"> J. Mydl谩r</a>, <a href="https://publications.waset.org/search?q=M.%20Zahat%C5%88ansk%C3%A1"> M. Zahat艌ansk谩</a>, <a href="https://publications.waset.org/search?q=K.%20Hricov%C3%A1"> K. Hricov谩 </a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Osteoporosis is a multifactorial disease that results in reduced quality of life, causes decreased bone strength, and changes in their microarchitecture. Mostly postmenopausal women are at risk. In our study, we measured anthropometric parameters of postmenopausal women (104 women of control group – CG and 105 women of osteoporotic group - OG) and determined TSH hormone levels and PTH as well as mineral elements - Ca, P, Mg and enzyme alkaline phosphatase. Through the correlation analysis in CG, we have found association based on age and BMI, P and Ca, as well as Mg and Ca; in OG we determined interdependence based on an association of age and BMI, age and Ca. Using the Student's t test, we found significantly important differences in biochemical parameters of Mg (p 藗 0,001) and TSH (p 藗 0,05) between CG and OG.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Factors" title="Factors">Factors</a>, <a href="https://publications.waset.org/search?q=bone%20mass%20density" title=" bone mass density"> bone mass density</a>, <a href="https://publications.waset.org/search?q=Central%20Europe" title=" Central Europe"> Central Europe</a>, <a href="https://publications.waset.org/search?q=biomarkers." title=" biomarkers."> biomarkers.</a> </p> <a href="https://publications.waset.org/10009355/hormones-and-mineral-elements-associated-with-osteoporosis-in-postmenopausal-women-in-eastern-slovakia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10009355/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10009355/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10009355/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10009355/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10009355/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10009355/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10009355/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10009355/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10009355/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10009355/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10009355.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">899</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Analysis of OPG Gene Polymorphism T245G (rs3134069) in Slovak Postmenopausal Women</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=I.%20Boro%C5%88ov%C3%A1">I. Boro艌ov谩</a>, <a href="https://publications.waset.org/search?q=J.%20Bernasovsk%C3%A1"> J. Bernasovsk谩</a>, <a href="https://publications.waset.org/search?q=J.%20K%C4%BEoc"> J. K木oc</a>, <a href="https://publications.waset.org/search?q=Z.%20Tomkov%C3%A1"> Z. Tomkov谩</a>, <a href="https://publications.waset.org/search?q=E.%20Petrej%C4%8D%C3%ADkov%C3%A1"> E. Petrej膷铆kov谩</a>, <a href="https://publications.waset.org/search?q=S.%20Ma%C4%8Dekov%C3%A1"> S. Ma膷ekov谩</a>, <a href="https://publications.waset.org/search?q=J.%20Por%C3%A1%C4%8Dov%C3%A1"> J. Por谩膷ov谩</a>, <a href="https://publications.waset.org/search?q=M.%20M.%20Bla%C5%A1%C4%8D%C3%A1kov%C3%A1"> M. M. Bla拧膷谩kov谩</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Osteoporosis is a common multifactorial disease with a strong genetic component characterized by reduced bone mass and increased risk of fractures. Genetic factors play an important role in the pathogenesis of osteoporosis. The aim of our study was to identify the genotype and allele distribution of T245G polymorphism in OPG gene in Slovak postmenopausal women. A total of 200 unrelated Slovak postmenopausal women with diagnosed osteoporosis and 200 normal controls were genotyped for T245G (rs3134069) polymorphism of OPG gene. Genotyping was performed using the Custom Taqman®SNP Genotyping assays. Genotypes and alleles frequencies showed no significant differences (p=0.5551; p=0.6022). The results of the present study confirm the importance of T245G polymorphism in OPG gene in the pathogenesis of osteoporosis.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=OPG%20gene" title="OPG gene">OPG gene</a>, <a href="https://publications.waset.org/search?q=osteoporosis" title=" osteoporosis"> osteoporosis</a>, <a href="https://publications.waset.org/search?q=Real-time%20PCR" title=" Real-time PCR"> Real-time PCR</a>, <a href="https://publications.waset.org/search?q=T245G%0D%0Apolymorphism." title=" T245G polymorphism."> T245G polymorphism.</a> </p> <a href="https://publications.waset.org/9999452/analysis-of-opg-gene-polymorphism-t245g-rs3134069-in-slovak-postmenopausal-women" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9999452/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9999452/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9999452/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9999452/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9999452/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9999452/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9999452/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9999452/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9999452/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9999452/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9999452.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2346</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> TNFRSF11B Gene Polymorphisms A163G and G11811C in Prediction of Osteoporosis Risk</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Boro%C5%88ov%C3%A1%20I.">Boro艌ov谩 I.</a>, <a href="https://publications.waset.org/search?q=Bernasovsk%C3%A1%20J."> Bernasovsk谩 J.</a>, <a href="https://publications.waset.org/search?q=K%C4%BEoc%20J."> K木oc J.</a>, <a href="https://publications.waset.org/search?q=Tomkov%C3%A1%20Z."> Tomkov谩 Z.</a>, <a href="https://publications.waset.org/search?q=Petrej%C4%8D%C3%ADkov%C3%A1%20E."> Petrej膷铆kov谩 E.</a>, <a href="https://publications.waset.org/search?q=Gabrikov%C3%A1%20D."> Gabrikov谩 D.</a>, <a href="https://publications.waset.org/search?q=Ma%C4%8Dekov%C3%A1%20S."> Ma膷ekov谩 S.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Osteoporosis is a complex health disease characterized by low bone mineral density, which is determined by an interaction of genetics with metabolic and environmental factors. Current research in genetics of osteoporosis is focused on identification of responsible genes and polymorphisms. TNFRSF11B gene plays a key role in bone remodeling. The aim of this study was to investigate the genotype and allele distribution of A163G (rs3102735) osteoprotegerin gene promoter and G1181C (rs2073618) osteoprotegerin first exon polymorphisms in the group of 180 unrelated postmenopausal women with diagnosed osteoporosis and 180 normal controls. Genomic DNA was isolated from peripheral blood leukocytes using standard methodology. Genotyping for presence of different polymorphisms was performed using the Custom Taqman®SNP Genotyping assays. Hardy-Weinberg equilibrium was tested for each SNP in the groups of participants using the chi-square (χ<sup>2</sup>) test. The distribution of investigated genotypes in the group of patients with osteoporosis were as follows: AA (66.7%), AG (32.2%), GG (1.1%) for A163G polymorphism; GG (19.4%), CG (44.4%), CC (36.1%) for G1181C polymorphism. The distribution of genotypes in normal controls were follows: AA (71.1%), AG (26.1%), GG (2.8%) for A163G polymorphism; GG (22.2%), CG (48.9%), CC (28.9%) for G1181C polymorphism. In A163G polymorphism the variant G allele was more common among patients with osteoporosis: 17.2% versus 15.8% in normal controls. Also, in G1181C polymorphism the phenomenon of more frequent occurrence of C allele in the group of patients with osteoporosis was observed (58.3% versus 53.3%). Genotype and allele distributions showed no significant differences (A163G: χ<sup>2</sup>=0.270, p=0.605; χ<sup>2</sup>=0.250, p=0.616; G1181C: χ<sup>2</sup>= 1.730, p=0.188; χ<sup>2</sup>=1.820, p=0.177). Our results represents an initial study, further studies of more numerous file and associations studies will be carried out. Knowing the distribution of genotypes is important for assessing the impact of these polymorphisms on various parameters associated with osteoporosis. Screening for identification of “at-risk” women likely to develop osteoporosis and initiating subsequent early intervention appears to be most effective strategy to substantially reduce the risks of osteoporosis.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Osteoporosis" title="Osteoporosis">Osteoporosis</a>, <a href="https://publications.waset.org/search?q=Real-time%20PCR%20method" title=" Real-time PCR method"> Real-time PCR method</a>, <a href="https://publications.waset.org/search?q=SNP%20polymorphisms." title=" SNP polymorphisms."> SNP polymorphisms.</a> </p> <a href="https://publications.waset.org/9997241/tnfrsf11b-gene-polymorphisms-a163g-and-g11811c-in-prediction-of-osteoporosis-risk" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9997241/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9997241/bibtex" target="_blank" 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Search results for: Z. Tomkov谩