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Tested in Immunohistochemistry (IHC), Flow Cytometry (Flow), Immunoprecipitation (IP) and Functional Assay (Functional) applications. This antibody reacts with Mouse samples. 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as a Method * define function as object methods * @type {Object} */ window.digitalData = { user: {}, page: {}, merchandising: {}, getQueryParam : function (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; }, getValOnce: function (value, cookieName, expiry, timeUnit) { var currentDate = new Date; var currentCookieValue; // timeUnit of 'm' is minutes represented in milliseconds // thus 86400000 = 24 hours = 1 day var interval = timeUnit == 'm' ? 60000 : 86400000; cookieName = cookieName ? cookieName : 'digitaldata_gvo'; value = value ? value : ''; expiry = expiry ? expiry : 0; currentCookieValue = this.getCookie(cookieName); if (value) { currentDate.setTime(currentDate.getTime() + expiry * interval); this.setCookie(cookieName, value, expiry == 0 ? 0 : currentDate); } return value == currentCookieValue ? '' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); var refReg = document.referrer; var referrerDomain = refReg.match(/:\/\/([^/]+)\//); if (referrerDomain !== null && referrerDomain[1].indexOf(masterDomain) == -1) { this.merchandising.referrer = referrerDomain; } } document.addEventListener('registerMerchandisingData', function (event) { for (var key in event.detail) { console.log("Listener data copied", key, event.detail[key] ); digitalData.merchandising[key] = event.detail[key]; } // Map some analytics attributes to merchandising session attributes digitalData.merchandising.sessionId = digitalData.merchandising.analyticsVisitorID; digitalData.merchandising.s_vi_low = digitalData.merchandising.analyticsVisitorIDLow; digitalData.merchandising.s_vi_high = digitalData.merchandising.analyticsVisitorIDHigh; console.log("digitalData: Captured registerMerchandisingData event"); digitalData.merchandisingDataInitted = true; // Call emailCampaignRecord if the digitalDataAnalyticsListener object is loaded if (typeof digitalDataAnalyticsListener != "undefined") { console.log("digitalData: Calling email campaign record"); digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. 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class="details-hero" ng-click="$ctrl.toggleImages('ADVANCED_VERIFICATION')"> <a class="link adv-verification-link animated-scroll" href="/sg/en/home/life-science/antibodies/invitrogen-antibody-validation.html"> <svg class="svg-icon advanced-verification-icon"> <use href="#icon-advanced-verification"></use> </svg> Advanced Verification </a> <p class="adv-verification-detail" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationSmLtr(event, this)"> This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. </p> </div> <div class="details-hero" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationPublishedFigures(event, this)"> <a class="link published-link animated-scroll " href="#image-gallery" onclick="window.THERMO_FISHER.pdp.inp.publishedFiguresHero(event, this)"> <svg class="svg-icon published-figures-icon"> <use href="#icon-published-figures"></use> </svg> 95 Published Figures </a> </div> <div class="details-hero"> 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( A ) Representative flow cytometric profiles of MSCs (upper, CD31 - , CD45 - , Ter119 - , Sca-1 + , and PDGFR-alpha + cells) and HSCs (bottom, c-Kit + , Lin - , and Sca-1 + cells). Microscopic views of MSCs (upper) and HSCs (bottom). ( B , C ) Cell proliferation of MSCs ( B ) and HSCs ( C ) 2, 4, 6, and 8 days after co-culture ( n \u003d 6). * p \u003c 0.05 and ** p \u003c 0.01 between direct and indirect co-culture. ( D ) MSC and HSC population in whole mesenchymal and hematopoietic cells. MSCs were sorted on day -1, and we waited until they attached to the bottom of the dish on day 0. After co-culture of MSCs and HSCs for 3, 5, and 7 days, cells were collected, sorted based on EGFP expression, and both cell types were detected using stem cell markers by flow cytometry. 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(a) RT-qPCR analyses of ZIKV genome in the brain of ZIKV-infected Ifnar -/- mice 7 dpi. (b) Picture of dissected brains from EB-injected mock- and ZIKV-infected mice at 7 dpi. (c) Quantification Evans blue fluorescence in brain slices from mock- and ZIKV-infected animals. Results are expressed means +- SEMs ( n \u003d 3) and analyzed using a Wilcoxon-Mann-Whitney test. ****, P \u003c 0.0001 compared to CT. (d) Three-micron consecutive paraffin sections were processed with Luxol blue and stained either with an anti-pan-flavivirus or an anti-CD45 (lymphoid cells) (brown labeling) antibody. Bars. 10 mum. (e) RT-qPCR analyses of inflammatory genes in ZIKV-infected brains. Results are expressed as means of the fold change ( n \u003d 3) using GAPDH as a housekeeping gene (genes where the ratio gene/housekeeping gene is statistically significant [ P \u003c 0.05] from CT) (see Fig. S8a ). (f) RT-qPCR analyses of CAMs in ZIKV-infected brains. Results are expressed as means of the fold change ( n \u003d 3) using GAPDH as a housekeeping gene (genes where the ratio gene/housekeeping gene is statistically significant [ P \u003c 0.05] from CT) (see Fig. S8a ). (g) RT-qPCR analyses of TJ and AJ genes in ZIKV-infected brains. Results are expressed as means of the fold change ( n \u003d 3) using GAPDH as a housekeeping gene (genes where the ratio gene/housekeeping gene is statistically significant [ P \u003c 0.05] from CT) (','shortDescription':'FIG 9 ZIKV-infected mouse brain displays local BBB impairment, leukocyte infiltration, and CAM upregulation. (a) RT-qPCR analyses of ZIKV genome in the brain of ZIKV-infected Ifnar -/- mice 7 dpi. (b) Picture of dissected brains from EB-injected mock- and ZIKV-infected mice at 7 dpi. (c) Quantification Evans blue fluorescence in brain slices from mock- and ZIKV-infected animals. Results are expressed means ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Aug 4, 2020, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'mBio','journalText':'mBio 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_27589_mBio.01183-20-f0009.jpg','benchSciPubmedId':'32753493'},{'sku':'14-0451-82','imageId':'1023482','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24775_EMS85829-f002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24775_EMS85829-f002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24775_EMS85829-f002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24775_EMS85829-f002.jpg?time\u003d20240507','sortOrder':'5','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 1, 2020, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Nature','journalText':'Nature 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24775_EMS85829-f002.jpg','benchSciPubmedId':'32296175'},{'sku':'14-0451-82','imageId':'952762','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20587_ijms-23-04900-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20587_ijms-23-04900-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20587_ijms-23-04900-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20587_ijms-23-04900-g001.jpg?time\u003d20240507','sortOrder':'6','description':'Compromised self-renewal of ASCs cultured from trappc9-null mice. ASCs were isolated from WT and trappc9-deficient mice and cultured as in Methods. Both WT and KO ASCs at passage-3 were subjected to analyses. ( A ) Confocal images showed that ASCs isolated from WT and trappc9-null (KO) mice expressed mesenchymal stem cell markers and were devoid of hematopoietic CD45. Arrowheads point to cells containing two or more nuclei. Scale bars: 100 mum. ( B ) Comparison of the growth rate between WT and trappc9-deficient (KO) ASCs. ASCs were cultured at a density of 1 x 10 5 in T25 flasks and counted every 24 h for 6 days. Cell counting was performed with a hemocytometer. ( C ) Quantification of cells with two or more nuclei revealed that trappc9-null (KO) ASCs were defective in cell division. Images captured from 3 randomly chosen visual fields from cells for each genotype were used for cell counting. ( D ) Apoptosis of cells in WT and trappc9-deficient (KO) ASC cultures was examined by flow cytometry-based analysis of phosphatidylserine exposure (Annexin V-FITC staining) and plasma membrane integrity (propidium iodide staining). Shown are dot plot graphs from one of three individual analyses. Similar observations were achieved in other two experiments. Data in ( B , C ) are Mean +- SD. Each symbol represents one experiment. Statistical significance was determined by unpaired two-tailed Student\u0027s t -test: * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001.','shortDescription':'Compromised self-renewal of ASCs cultured from trappc9-null mice. ASCs were isolated from WT and trappc9-deficient mice and cultured as in Methods. Both WT and KO ASCs at passage-3 were subjected to analyses. ( A ) Confocal images showed that ASCs isolated from WT and trappc9-null (KO) mice expressed mesenchymal stem cell markers and were devoid of hematopoietic CD45. Arrowheads point to cells containing tw... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunocytochemistry (ICC/IF)','title':'CD45 Antibody (14-0451-82) in ICC/IF','appAbv':'ICC/IF','dateTime':'Apr 28, 2022, 4:00:00 AM','appName':'Immunocytochemistry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20587_ijms-23-04900-g001.jpg','benchSciPubmedId':'35563289'},{'sku':'14-0451-82','imageId':'1023227','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24776_41467_2021_23770_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24776_41467_2021_23770_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24776_41467_2021_23770_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24776_41467_2021_23770_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'7','description':'Diurnal proliferation of adipocyte progenitor cells (APCs) in epididymal adipose tissue (eWAT). a Experimental model: adipose progenitor cells (APC) within the eWAT and iWAT stromal vascular cells were isolated at ZT0 and ZT12 from lean mice fed ad libitum control chow, for further gene expression and immunostaining analysis. b , c RT-PCR analysis reveals expression of progenitor (Dcn and CD34), endothelial (CD31), and lymphocyte (CD45) markers in eWAT/APC and eWAT/non-APC cells from lean mice isolated at ZT0 and ZT12 ( n \u003d 5 animals for APC - and n \u003d 10 animals for APC + /zeitgeber time, ZT). mRNA levels for lean mice at APC + /ZT0 were set to 1 for all genes. d Representative staining of KI67 (vs. DAPI) in eWAT-APC (scale bar \u003d 50 um). Staining performed once from 3 biological replicates. e , f RT-PCR analysis reveals expression of circadian (left panel) and proliferation genes (right panel) in eWAT/APC ( e ) and eWAT / non-APC cells ( f ) from lean mice isolated at ZT0 and ZT12 ( n \u003d 5 animals for APC - and n \u003d 10 animals for APC + /ZT). mRNA levels for lean mice at APC + /ZT0 were set to 1 for all genes. g Experimental model: EdU was administered to lean mice fed ad libitum control chow at ZT0 and ZT12. eWAT and iWAT SVF were isolated from fat pads harvested 4 h following EdU injection and the subsequent adipose APC were isolated for further analysis. h Representative fluorescence activated cell sorting of EdU-positive cells in eWAT-APC isolated at ZT4 and ZT16, 4 h follo','shortDescription':'Diurnal proliferation of adipocyte progenitor cells (APCs) in epididymal adipose tissue (eWAT). a Experimental model: adipose progenitor cells (APC) within the eWAT and iWAT stromal vascular cells were isolated at ZT0 and ZT12 from lean mice fed ad libitum control chow, for further gene expression and immunostaining analysis. b , c RT-PCR analysis reveals expression of progenitor (Dcn and CD34), endothelial... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunocytochemistry (ICC/IF)','title':'CD45 Antibody (14-0451-82) in ICC/IF','appAbv':'ICC/IF','dateTime':'Jun 9, 2021, 4:00:00 AM','appName':'Immunocytochemistry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24776_41467_2021_23770_Fig2_HTML.jpg','benchSciPubmedId':'34108488'},{'sku':'14-0451-82','imageId':'877340','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time\u003d20240507','sortOrder':'8','description':'3 Fig CXCL12 is functionally important for maintaining stromal-hematopoietic coupling. ( A ) Conceptual diagram of CXCL12 conditional deletion experiment. Col2a1-cre ; Cxcl12 GFP/+ ; R26R tdTomato mice were mated with Cxcl12 fl/fl mice to generate Col2a1-cre ; Cxcl12 GFP/fl ; R26R tdTomato (Col2a1-CXCL12 cKO) and Cxcl12 GFP/fl ; R26R tdTomato (Control) mice. In Col2a1-CXCL12 cKO mice, Cxcl12-GFP + cells lose functional CXCL12 expression but still express GFP in a Cxcl12 promoter/enhancer-dependent manner. ( B ) CD45 staining of Control (left panels) and Col2a1-CXCL12 cKO (right panels) bone marrow. Dotted area \u003d magnified view of Cxcl12 -GFP + reticular stromal cells and neighboring CD45 + hematopoietic cells. Green \u003d Cxcl12-GFP; red \u003d tdTomato; magenta \u003d CD45-Alexa647; gray \u003d DAPI. Scale bar \u003d 10 mum. n \u003d 4 mice per group. ( C ) Flow cytometry analysis of Control and Col2a1-CXCL12 cKO bone marrow cells. The percentage of CD45 + cells in total bone marrow cells (center) and CD45 + GFP + cells in whole GFP + fraction (right). n \u003d 4 mice per group. Two-tailed, Mann-Whitney U test. All data are presented as mean +- SD.','shortDescription':'3 Fig CXCL12 is functionally important for maintaining stromal-hematopoietic coupling. ( A ) Conceptual diagram of CXCL12 conditional deletion experiment. Col2a1-cre ; Cxcl12 GFP/+ ; R26R tdTomato mice were mated with Cxcl12 fl/fl mice to generate Col2a1-cre ; Cxcl12 GFP/fl ; R26R tdTomato (Col2a1-CXCL12 cKO) and Cxcl12 GFP/fl ; R26R tdTomato (Control) mice. In Col2a1-CXCL12 cKO mice, Cxcl12-GFP + cells los... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)','title':'CD45 Antibody (14-0451-82) in ICC/IF, Flow','appAbv':'Flow','dateTime':'Jun 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research','journalText':'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg','benchSciPubmedId':'33651379'},{'sku':'14-0451-82','imageId':'876396','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14822_urn-x-wiley-15821838-media-jcmm16285-jcmm16285-fig-0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14822_urn-x-wiley-15821838-media-jcmm16285-jcmm16285-fig-0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14822_urn-x-wiley-15821838-media-jcmm16285-jcmm16285-fig-0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14822_urn-x-wiley-15821838-media-jcmm16285-jcmm16285-fig-0001.jpg?time\u003d20240507','sortOrder':'9','description':'1 FIGURE Expression of Cyp26a1 in mouse uterine tissue and uterine NK cells during the peri-implantation period. (A) qPCR to detect the expression of Cyp26a1 on gd4-gd7 uterine tissue. (B) Western blotting to detect the expression of Cyp26a1 on gd4-gd7 uterine tissue. (C) qPCR to detect the expression of Cyp26a1 in CD45 + CD3 - CD122 + NK cells isolated from the uterus and spleen on gd5. (D) qPCR to detect the expression of Cyp26a1 in CD45 + CD3 - CD122 + NK cells isolated from the uterus on gd4-gd7. (E) Representative graph of flow cytometric assays to detect CD45 + CD3 - CD122 + Cyp26a1 + NK cells in the uterus on gd4-gd7, the marker molecules were as follows: CD3-PE, CD45-PerCP-Cy5.5, CD122-APC and Cyp26a1-Alexa Fluor 488, The cells under gate CD45 + CD3 - shown in the figure. (F) Percentages of Cyp26a1 + NK cells in gated CD45 + CD3 - CD122 + NK and CD122 + NK cells in gated CD45 + CD3 - cells in the uterus on gd4-gd7. (G) Upper picture: immunofluorescence detection of Cyp26a1 expression in CD45 + CD3 - CD122 + NK cells isolated from the uterus on gd5 (63 x objective); lower picture: confocal photography of Cyp26a1 + NK cells and Cyp26a1 - NK cells isolated from the uterus on gd5 (20 x and 63 x objective). Data were means +- SEM from three biological replicates, *represents P \u003c .05, **represents P \u003c .01 (two-tailed unpaired Student\u0027s t test) (A and C). Data were representative of two (A, B and C) or three (E, F and G) independent experiments','shortDescription':'1 FIGURE Expression of Cyp26a1 in mouse uterine tissue and uterine NK cells during the peri-implantation period. (A) qPCR to detect the expression of Cyp26a1 on gd4-gd7 uterine tissue. (B) Western blotting to detect the expression of Cyp26a1 on gd4-gd7 uterine tissue. (C) qPCR to detect the expression of Cyp26a1 in CD45 + CD3 - CD122 + NK cells isolated from the uterus and spleen on gd5. (D) qPCR to detect ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunocytochemistry (ICC/IF)','title':'CD45 Antibody (14-0451-82) in ICC/IF','appAbv':'ICC/IF','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Immunocytochemistry','type':'Published Figures','journalTitle':'Journal of cellular and molecular medicine','journalText':'Journal of cellular and molecular medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14822_urn-x-wiley-15821838-media-jcmm16285-jcmm16285-fig-0001.jpg','benchSciPubmedId':'33438367'},{'sku':'14-0451-82','imageId':'876420','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15168_dmm-13-044404-g2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15168_dmm-13-044404-g2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15168_dmm-13-044404-g2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15168_dmm-13-044404-g2.jpg?time\u003d20240507','sortOrder':'10','description':'Fig. 2. Optimized sample preparation protocol for scRNA-seq captures major lung cell types of the epithelial, endothelial, immune and mesenchymal lineages. (A) Distribution of the 4 color-coded lineages quantified from published whole-lung scRNA-seq datasets (; ; preprint). (B) Confocal images of immunostained adult Rosa Sun1GFP/+ ; Shh Cre/+ lungs, in which epithelial cell nuclei are genetically marked by nuclear envelope-targeted GFP (), whereas ERG and CD45 (also known as PTPRC) mark endothelial and immune cells, respectively, and triple-negative nuclei (DAPI) are considered mesenchymal. We used the GFP reporter instead of NKX2-1 because both NKX2-1 and ERG are rabbit antibodies. Percentages are from 2 lungs with 3 images each containing thousands of cells. Scale bar: 10 mum. (C) An all-inclusive FACS gating strategy to separate all live cells (Sytox Blue negative) into the 4 lung cell lineages. (D) Skewed distributions of the 4 color-coded lung cell lineages from FACS are compensated by remixing them in equal proportions, adjusted for lineage-specific cell viability, for scRNA-seq. 3245 cells were sequenced. Distributions of the constituent cell types in each lineage can be obtained from scRNA-seq. airway cells, ciliated and club cells; AM, alveolar macrophages; A/VSM, airway/vascular smooth muscle cells; baso, basophils; DC, dendritic cells; IM, interstitial macrophages; mono, monocytes; neu, neutrophils; NK cells, natural killer cells.','shortDescription':'Fig. 2. Optimized sample preparation protocol for scRNA-seq captures major lung cell types of the epithelial, endothelial, immune and mesenchymal lineages. (A) Distribution of the 4 color-coded lineages quantified from published whole-lung scRNA-seq datasets (; ; preprint). (B) Confocal images of immunostained adult Rosa Sun1GFP/+ ; Shh Cre/+ lungs, in which epithelial cell nuclei are genetically marked by ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunocytochemistry (ICC/IF)','title':'CD45 Antibody (14-0451-82) in ICC/IF','appAbv':'ICC/IF','dateTime':'Jun 26, 2020, 4:00:00 AM','appName':'Immunocytochemistry','type':'Published Figures','journalTitle':'Disease models \u0026 mechanisms','journalText':'Disease models \u0026 mechanisms 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15168_dmm-13-044404-g2.jpg','benchSciPubmedId':'32461220'},{'sku':'14-0451-82','imageId':'626493','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4922_pone0206539g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4922_pone0206539g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4922_pone0206539g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4922_pone0206539g003.jpg?time\u003d20240507','sortOrder':'11','description':'Fig 3 Immunohistological features of serially transplanted cervical cancer PDXs. Representative example of a PDX showing comparable histology (H\u0026E) and immunoreactivity for diagnostic markers of cervical cancer in the primary biopsy and primary and secondary PDXs. Columns 2 and 3 show staining patterns for p16 INK4a (brown nuclear staining), HPV (brown nuclear and cytoplasmic immunostaining). Insets, isotype IgG control showing negative immunostaining. Scale bars 10 mum.','shortDescription':'Fig 3 Immunohistological features of serially transplanted cervical cancer PDXs. Representative example of a PDX showing comparable histology (H\u0026E) and immunoreactivity for diagnostic markers of cervical cancer in the primary biopsy and primary and secondary PDXs. Columns 2 and 3 show staining patterns for p16 INK4a (brown nuclear staining), HPV (brown nuclear and cytoplasmic immunostaining). Insets, is... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunocytochemistry (ICC/IF)','title':'CD45 Antibody (14-0451-82) in ICC/IF','appAbv':'ICC/IF','dateTime':'Mar 29, 2019, 4:00:00 AM','appName':'Immunocytochemistry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4922_pone0206539g003.jpg','benchSciPubmedId':'30365542'},{'sku':'14-0451-82','imageId':'352262','imageUrl':'https://www.thermofisher.com/antibody/images/650/CD45_27912060_IF_9_nihms874807f3_20180524.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/CD45_27912060_IF_9_nihms874807f3_20180524.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/CD45_27912060_IF_9_nihms874807f3_20180524.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/CD45_27912060_IF_9_nihms874807f3_20180524.jpg?time\u003d20240507','sortOrder':'12','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry','altTag':'CD45 Antibody in Immunocytochemistry (ICC/IF)','title':'CD45 Antibody (14-0451-82) in ICC/IF','appAbv':'ICC/IF','dateTime':'Dec 1, 2016, 5:00:00 AM','appName':'Immunocytochemistry','type':'Published Figures','journalTitle':'Cell','journalText':'Cell 2016 - ','sourceType':'3','benchsci':true,'imageName':'CD45_27912060_IF_9_nihms874807f3_20180524.jpg','benchSciPubmedId':'27912060'},{'sku':'14-0451-82','imageId':'351137','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3200_jciinsight-1-87680-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3200_jciinsight-1-87680-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3200_jciinsight-1-87680-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3200_jciinsight-1-87680-g001.jpg?time\u003d20240507','sortOrder':'13','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry and Immunohistochemistry (Paraffin)','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry and Immunohistochemistry (Paraffin)','altTag':'CD45 Antibody in Immunocytochemistry, Immunohistochemistry (Paraffin) (ICC/IF, IHC (P))','title':'CD45 Antibody (14-0451-82) in ICC/IF, IHC (P)','appAbv':'IHC (P)','dateTime':'Jul 21, 2016, 4:00:00 AM','appName':'Immunohistochemistry (Paraffin)','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2016 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3200_jciinsight-1-87680-g001.jpg','benchSciPubmedId':'27699223'},{'sku':'14-0451-82','imageId':'327697','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12858_ncomms9835-f2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12858_ncomms9835-f2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12858_ncomms9835-f2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12858_ncomms9835-f2.jpg?time\u003d20240507','sortOrder':'14','description':'Figure 2 Loss of Gata5 from renal endothelial cells leads to renal alterations. ( a ) GATA5 is expressed in the kidney as assessed by western blot performed on total kidney extracts. ( b ) Gata5 is essentially expressed in the glomeruli as assessed by qPCR on isolated glomeruli (Glo) and microdissected tubules (Tub) from Wt mice kidneys. ( n \u003d3-5 per group). The results are reported as mean+-s.e.m. * P \u003c0.05 versus Gata5 +/+ mice (Mann-Whitney test). ( c , d ) Specific deletion of Gata5 in endothelial cells (e Gata5-null mice) virtually abolished renal and glomerular expression of Gata5 ( n \u003d3 per group). The results are reported as mean+-s.e.m. * P \u003c0.05 versus eGata5 +/+ mice (Mann-Whitney test). ( e ) The expression of the glomerular genes Nphs1 (nephrin) and Nphs2 (podocin) as measured by qPCR ( n \u003d6 per group) was increased in Gata5 -null mice. The results are reported as mean+-s.e.m. * P \u003c0.05 versus Gata5 +/+ mice; *** P \u003c0.005 versus Gata5 +/+ mice ( t -test for nephrin; Mann-Whitney test for podocin). ( f - i ) Absence of Gata5 induces glomerular lesions (sections are stained with periodic acid Schiff; scale bar, 30 mum; n \u003d5 per group) and renal inflammation as assessed by leucocytes CD45 immunostaining (scale bar, 200 mum; n \u003d4 per group). The results are reported as mean+-s.e.m. *** P \u003c0.005 versus Gata5 +/+ mice (Mann-Whitney test). ( j - n ) Deletion of Gata5 from endothelial cells reproduces the renal phenotype of global Gata5 deletion: both Nephs1 and Nphs2 tr','shortDescription':'Figure 2 Loss of Gata5 from renal endothelial cells leads to renal alterations. ( a ) GATA5 is expressed in the kidney as assessed by western blot performed on total kidney extracts. ( b ) Gata5 is essentially expressed in the glomeruli as assessed by qPCR on isolated glomeruli (Glo) and microdissected tubules (Tub) from Wt mice kidneys. ( n \u003d3-5 per group). The results are reported as mean+-s.e.m. * P \u003c0.0... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)','title':'CD45 Antibody (14-0451-82) in ICC/IF, Flow','appAbv':'Flow','dateTime':'Nov 30, 2015, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2015 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12858_ncomms9835-f2.jpg','benchSciPubmedId':'26617239'},{'sku':'14-0451-82','imageId':'312933','imageUrl':'https://www.thermofisher.com/antibody/images/650/pone0081030g005-20180918151446.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/pone0081030g005-20180918151446.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/pone0081030g005-20180918151446.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/pone0081030g005-20180918151446.jpg?time\u003d20240507','sortOrder':'15','description':'Figure 5 beta-catenin activation enhances hemangioblast formation. (A) (i) Scoring of the number of BL-CFC compared to the number of EB\u0026apos;sfor each condition by day 8 of differentiation shows activation of thecanonical Wnt pathway (DP-betaC or BIO) results in higher percentage ofBL-CFC compared to control cultures (Mean %, +/- SEM, n\u003d3). (ii)Hemangioblasts/Early hematopoietic progenitors (CONDITION 2) wereanalysis for expression of mesodermal markers Flk1 and Brachyury by flowcytometry. (iii) RT-PCR analysis of key self-renewal and differentiationgenes. (B) Flow cytometry analysis was performed on thehemangioblast/early hematopoietic progenitors to determine thepercentage of cells expressing CD41, CD45, c-Kit, Sca1 and Flt3. Gatingon the CD41 + , CD45 + population revealed that theseearly hematopoietic progenitors also expressed the HSC markers Sca1 andc-Kit (Representative images shown, n\u003d3). (C) (i) Total cell populationfrom CONDITION 2 were analyzed for key HSC markers Sca1 and c-Kit byflow cytometry. (ii) The early hematopoietic progenitor populations(Sca1 + c-Kit + cells) were sorted andImmunofluorescence performed to confirm higher levels of total andactive beta-catenin in DP-betaC -tet and E14 cells + BIO. (iii) RT-PCRanalysis of key hematopoietic genes within theSca-1 + c-kit + hematopoietic progenitor cellsand (iv) erythroid/globin genes. The control cells (DP-betaC + tet or E14ES cells -BIO) were used as calibrators and the fold change wascalculated using the 2 -','shortDescription':'Figure 5 beta-catenin activation enhances hemangioblast formation. (A) (i) Scoring of the number of BL-CFC compared to the number of EB\u0026apos;sfor each condition by day 8 of differentiation shows activation of thecanonical Wnt pathway (DP-betaC or BIO) results in higher percentage ofBL-CFC compared to control cultures (Mean %, +/- SEM, n\u003d3). (ii)Hemangioblasts/Early hematopoietic progenitors (CONDITION 2) we... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunocytochemistry (ICC/IF)','title':'CD45 Antibody (14-0451-82) in ICC/IF','appAbv':'ICC/IF','dateTime':'Jul 29, 2014, 4:00:00 AM','appName':'Immunocytochemistry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2014 - ','sourceType':'3','benchsci':true,'imageName':'pone0081030g005-20180918151446.jpg','benchSciPubmedId':'24324557'},{'sku':'14-0451-82','imageId':'736368','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8108_cancers-10-00403-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8108_cancers-10-00403-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8108_cancers-10-00403-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8108_cancers-10-00403-g004.jpg?time\u003d20240507','sortOrder':'16','description':'Figure 4 Regulation of CD45 + cell number by both MEK and Hh signaling pathways. ( A ) Representative immunofluorescent staining images of CD45 + cells in liver tissues after drug treatments. ( B ) Summary of A from 10 images in each group (from at least 3 mice) with the number of CD45 + cells per field under microscope (200x). ( C ) Summary of flow cytometry analysis of CD45+ cells in different treatment groups (from three mice/group). * indicates p \u003c 0.05 and ** indicates a more than additive effect via BLISS independence analysis.','shortDescription':'Figure 4 Regulation of CD45 + cell number by both MEK and Hh signaling pathways. ( A ) Representative immunofluorescent staining images of CD45 + cells in liver tissues after drug treatments. ( B ) Summary of A from 10 images in each group (from at least 3 mice) with the number of CD45 + cells per field under microscope (200x). ( C ) Summary of flow cytometry analysis of CD45+ cells in different treatm... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))','title':'CD45 Antibody (14-0451-82) in IHC (P)','appAbv':'IHC (P)','dateTime':'Oct 26, 2018, 4:00:00 AM','appName':'Immunohistochemistry (Paraffin)','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8108_cancers-10-00403-g004.jpg','benchSciPubmedId':'30373214'},{'sku':'14-0451-82','imageId':'314338','imageUrl':'https://www.thermofisher.com/antibody/images/650/CD45_29098081_IF_9_JOPH2017-1639012002_20180524.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/CD45_29098081_IF_9_JOPH2017-1639012002_20180524.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/CD45_29098081_IF_9_JOPH2017-1639012002_20180524.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/CD45_29098081_IF_9_JOPH2017-1639012002_20180524.jpg?time\u003d20240507','sortOrder':'17','description':'Figure 2 Characteristics histopathological findings of lacrimal gland in a mouse model of cGVHD. Hematoxylin \u0026 eosin (H\u0026E) staining for lacrimal gland tissue sections from GVHD-affected mouse model (a, c) and syngeneic control (b, d). Immunostaining for CD45 + cells (in green and red arrow) and cell nuclei (stained with 4\u0026apos;,6-diamidino-2-phenylindole (DAPI) in blue) in the lacrimal gland collected from the GVHD-impaired mice (e) and syngeneic controls (f). Transmission electron microscopic (TEM) findings of the lacrimal gland in a mouse model of cGVHD (g, i) and the syngeneic controls (h, j). (g, h) Yellow arrows, secretory vesicles. Scale bar \u003d 50 mu m (a, b), 25 mu m (c, d), 50 mu m (e, f), 5 mu m (g, h), and 0.5 mu m (i, j). cGVHD mice, n \u003d 10; syngeneic control mice, n \u003d 10. Representative figures from three independent experiments.','shortDescription':'Figure 2 Characteristics histopathological findings of lacrimal gland in a mouse model of cGVHD. Hematoxylin \u0026 eosin (H\u0026E) staining for lacrimal gland tissue sections from GVHD-affected mouse model (a, c) and syngeneic control (b, d). Immunostaining for CD45 + cells (in green and red arrow) and cell nuclei (stained with 4\u0026apos;,6-diamidino-2-phenylindole (DAPI) in blue) in the lacrimal gland collected from ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))','title':'CD45 Antibody (14-0451-82) in IHC (P)','appAbv':'IHC (P)','dateTime':'Mar 10, 2022, 5:00:00 AM','appName':'Immunohistochemistry (Paraffin)','type':'Published Figures','journalTitle':'Journal of ophthalmology','journalText':'Journal of ophthalmology 2022 - ','sourceType':'3','benchsci':true,'imageName':'CD45_29098081_IF_9_JOPH2017-1639012002_20180524.jpg','benchSciPubmedId':'29098081'},{'sku':'14-0451-82','imageId':'351139','imageUrl':'https://www.thermofisher.com/antibody/images/650/14569882-27699223-Ki-67-jciinsight-1-87680-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/14569882-27699223-Ki-67-jciinsight-1-87680-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/14569882-27699223-Ki-67-jciinsight-1-87680-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/14569882-27699223-Ki-67-jciinsight-1-87680-g005.jpg?time\u003d20240507','sortOrder':'18','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (Paraffin)','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (Paraffin)','altTag':'CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))','title':'CD45 Antibody (14-0451-82) in IHC (P)','appAbv':'IHC (P)','dateTime':'Jul 21, 2016, 4:00:00 AM','appName':'Immunohistochemistry (Paraffin)','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2016 - ','sourceType':'3','benchsci':true,'imageName':'14569882-27699223-Ki-67-jciinsight-1-87680-g005.jpg','benchSciPubmedId':'27699223'},{'sku':'14-0451-82','imageId':'351105','imageUrl':'https://www.thermofisher.com/antibody/images/650/14140282-27699223-CD140b-PDGFRB-jciinsight-1-87680-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/14140282-27699223-CD140b-PDGFRB-jciinsight-1-87680-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/14140282-27699223-CD140b-PDGFRB-jciinsight-1-87680-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/14140282-27699223-CD140b-PDGFRB-jciinsight-1-87680-g003.jpg?time\u003d20240507','sortOrder':'20','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (Paraffin)','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (Paraffin)','altTag':'CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))','title':'CD45 Antibody (14-0451-82) in IHC (P)','appAbv':'IHC (P)','dateTime':'Jul 21, 2016, 4:00:00 AM','appName':'Immunohistochemistry (Paraffin)','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2016 - ','sourceType':'3','benchsci':true,'imageName':'14140282-27699223-CD140b-PDGFRB-jciinsight-1-87680-g003.jpg','benchSciPubmedId':'27699223'},{'sku':'14-0451-82','imageId':'323879','imageUrl':'https://www.thermofisher.com/antibody/images/650/14045182-26151762-CD45-elife07125fs004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/14045182-26151762-CD45-elife07125fs004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/14045182-26151762-CD45-elife07125fs004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/14045182-26151762-CD45-elife07125fs004.jpg?time\u003d20240507','sortOrder':'21','description':'Figure 3--figure supplement 1. Microenvironmental remodeling in Ptf1a cKO; Kras G12D pancreata. Pancreata were harvested 2 weeks following TM administration (0.17 mg/g) to mice of the indicated genotypes. ( A - D ) Immunofluorescence for the PanIN marker CLDN18 (red), and the leukocyte marker CD45 (green), revealing association of leukocytes with PanINs in Ptf1a cKO; Kras G12D . ( E - H ) IHC for alpha-SMA, highlighting the activation of pancreatic stellate cells in Ptf1a cKO; Kras G12D pancreata. ( I - L ) Sirius Red staining, highlighting widespread fibrosis in Ptf1a cKO; Kras G12D . Scale bars: ( A - D ) 50 mum, ( E - L ) 200 mum. DOI: http://dx.doi.org/','shortDescription':'Figure 3--figure supplement 1. Microenvironmental remodeling in Ptf1a cKO; Kras G12D pancreata. Pancreata were harvested 2 weeks following TM administration (0.17 mg/g) to mice of the indicated genotypes. ( A - D ) Immunofluorescence for the PanIN marker CLDN18 (red), and the leukocyte marker CD45 (green), revealing association of leukocytes with PanINs in Ptf1a cKO; Kras G12D . ( E - H ) IHC for alpha-SMA,... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))','title':'CD45 Antibody (14-0451-82) in IHC (P)','appAbv':'IHC (P)','dateTime':'Jul 7, 2015, 4:00:00 AM','appName':'Immunohistochemistry (Paraffin)','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2015 - ','sourceType':'3','benchsci':true,'imageName':'14045182-26151762-CD45-elife07125fs004.jpg','benchSciPubmedId':'26151762'},{'sku':'14-0451-82','imageId':'310341','imageUrl':'https://www.thermofisher.com/antibody/images/650/14045182-26151762-CD45-elife07125fs008.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/14045182-26151762-CD45-elife07125fs008.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/14045182-26151762-CD45-elife07125fs008.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/14045182-26151762-CD45-elife07125fs008.jpg?time\u003d20240507','sortOrder':'22','description':'Figure 4--figure supplement 3. High-dose tamoxifen administration does not induce pancreatitis. ( A - D ) Lowand ( A\u0026apos; - D\u0026apos; ) high-magnification H\u0026E staining of wild-type pancreata, fixed 24 hr after indicated treatment. ( E - H ) Immunofluorescence for CK19 (red), CD45 (green) and DAPI (blue), highlighting inflammatory cells in the exocrine pancreas. Scale bars: ( A - D ) 200 mum, ( A\u0026apos; - D\u0026apos; ) 100 mum, ( E - H ) 50 mum. DOI: http://dx.doi.org/','shortDescription':'Figure 4--figure supplement 3. High-dose tamoxifen administration does not induce pancreatitis. ( A - D ) Lowand ( A\u0026apos; - D\u0026apos; ) high-magnification H\u0026E staining of wild-type pancreata, fixed 24 hr after indicated treatment. ( E - H ) Immunofluorescence for CK19 (red), CD45 (green) and DAPI (blue), highlighting inflammatory cells in the exocrine pancreas. Scale bars: ( A - D ) 200 mum, ( A\u0026apos; - D\u0026ap... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))','title':'CD45 Antibody (14-0451-82) in IHC (P)','appAbv':'IHC (P)','dateTime':'Jul 7, 2015, 4:00:00 AM','appName':'Immunohistochemistry (Paraffin)','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2015 - ','sourceType':'3','benchsci':true,'imageName':'14045182-26151762-CD45-elife07125fs008.jpg','benchSciPubmedId':'26151762'},{'sku':'14-0451-82','imageId':'878757','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15191_fmolb-08-737472-g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15191_fmolb-08-737472-g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15191_fmolb-08-737472-g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15191_fmolb-08-737472-g007.jpg?time\u003d20240507','sortOrder':'23','description':'FIGURE 7 miR-223-5p antagonist promoted diabetic corneal epithelial wound repair and nerve regeneration by modulating inflammatory process. (A) Immunofluorescence corneal staining reflected CD45 protein expression in the normal mice (NW group), diabetic mice (DW group), diabetic mice subconjunctivally injected with miR-223-5p antagomir (DW + antagomir group) or antagomir NC (DW + NC group) 24 h post-injury. (B) qRT-PCR results revealing the CD45 mRNA expression of the corneal epithelium in each group. (C-E) qRT-PCR detected the mRNA expression of inflammatory factors including TNF-alpha, IL-1beta, and IL-6 in the corneal epithelium of these four groups at 24 h post-wounding. (B-E) Data were analyzed by one-way ANOVA. If significant, multiple comparations were then performed. * p -value of \u003c0.05.','shortDescription':'FIGURE 7 miR-223-5p antagonist promoted diabetic corneal epithelial wound repair and nerve regeneration by modulating inflammatory process. (A) Immunofluorescence corneal staining reflected CD45 protein expression in the normal mice (NW group), diabetic mice (DW group), diabetic mice subconjunctivally injected with miR-223-5p antagomir (DW + antagomir group) or antagomir NC (DW + NC group) 24 h post-injury.... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))','title':'CD45 Antibody (14-0451-82) in IHC (F)','appAbv':'IHC (F)','dateTime':'Apr 13, 2023, 4:00:00 AM','appName':'Immunohistochemistry (Frozen)','type':'Published Figures','journalTitle':'Frontiers in molecular biosciences','journalText':'Frontiers in molecular biosciences 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15191_fmolb-08-737472-g007.jpg','benchSciPubmedId':'34513931'},{'sku':'14-0451-82','imageId':'877752','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15192_ijms-22-09484-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15192_ijms-22-09484-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15192_ijms-22-09484-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15192_ijms-22-09484-g002.jpg?time\u003d20240507','sortOrder':'24','description':'Figure 2 Neutralization of extracellular \'\'Cold-inducible RNA-binding protein\'\' (eCIRP) decreases leukocyte accumulation in ischemic tissue. ( a ) The scatter plot displays the relative number of CD45 + (pan-leukocyte marker) cells (per mm 2 ) in the ischemic gastrocnemius muscles of mice that received phosphate-buffered saline (PBS), isotype antibody (ISO) (control groups), or the anti-CIRP antibody (Anti-CIRP) and were sacrificed 7 days after femoral artery ligation (FAL). Data are means +- S.E.M., n \u003d 5 per group. n.s. p \u003e 0.05, * p \u003c 0.05 (PBS vs. ISO vs. Anti-CIRP) by one-way ANOVA with the Tukey\u0027s multiple comparisons test, a defined ischemic area (1.5 mm 2 ) of muscle tissue was analyzed per mouse. ( b ) Representative immunofluorescence staining of ischemic gastrocnemius muscles of mice treated with PBS (top), isotype antibody (middle), or anti-CIRP antibody (bottom) 7 days after FAL. Cells were stained with an antibody against CD45 (green) and DAPI (blue) to label nucleic DNA. Scale bars represent 50 um.','shortDescription':'Figure 2 Neutralization of extracellular \'\'Cold-inducible RNA-binding protein\'\' (eCIRP) decreases leukocyte accumulation in ischemic tissue. ( a ) The scatter plot displays the relative number of CD45 + (pan-leukocyte marker) cells (per mm 2 ) in the ischemic gastrocnemius muscles of mice that received phosphate-buffered saline (PBS), isotype antibody (ISO) (control groups), or the anti-CIRP antibody (Anti-... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))','title':'CD45 Antibody (14-0451-82) in IHC (F)','appAbv':'IHC (F)','dateTime':'Aug 31, 2021, 4:00:00 AM','appName':'Immunohistochemistry (Frozen)','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15192_ijms-22-09484-g002.jpg','benchSciPubmedId':'34502391'},{'sku':'14-0451-82','imageId':'875966','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14904_biology-10-00472-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14904_biology-10-00472-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14904_biology-10-00472-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14904_biology-10-00472-g001.jpg?time\u003d20240507','sortOrder':'25','description':'Figure 1 Induction of EAE and IL-16 production by tissues of EAE mice. ( A ) C57BL/6J female mice were injected with MOG 35-55 emulsified in CFA, together with PTX. Clinical symptoms were recorded over the course of 26 days. Control mice received PBS + CFA + PTX immunisation. N \u003d 15. Statistical significance was determined by one-way ANOVA with repeated measures and Bonferroni post-hoc tests. ** p \u003c 0.01, *** p \u003c 0.001. ( B - D ) CNS tissues were harvested from PBS control mice on day 16 and EAE mice on day 12, day 16 and day 26. Spinal cord ( B ), hippocampus ( C ) and cerebellum ( D ) tissues were stained for CD45 and counterstained with haematoxylin. Representative images are shown. The percentage of CD45 + cells was quantified for each group; results are expressed as mean +- SEM. N \u003d 3 for all groups. Statistical significance was determined by one-way ANOVA with Bonferroni post-hoc tests. ( E ) Spleen cell suspensions prepared from day 16 of PBS or MOG 35-55 immunised mice were incubated either with media alone or media containing MOG 35-55 (50 mug/mL), or ConA (50 mug/mL). Supernatants were collected after 72 h of culture and used to detect IL-16 production by ELISA. Results are expressed as the mean +- SEM. PBS n \u003d 4 and EAE n \u003d 6. Statistical significance was determined by one-way ANOVA with Bonferroni post hoc tests. ( F ) Supernatants from homogenised spinal cord, cerebellum or cerebrum were collected and prepared to analyse IL-16 levels by ELISA. PBS n \u003d 3, EAE n \u003d','shortDescription':'Figure 1 Induction of EAE and IL-16 production by tissues of EAE mice. ( A ) C57BL/6J female mice were injected with MOG 35-55 emulsified in CFA, together with PTX. Clinical symptoms were recorded over the course of 26 days. Control mice received PBS + CFA + PTX immunisation. N \u003d 15. Statistical significance was determined by one-way ANOVA with repeated measures and Bonferroni post-hoc tests. ** p \u003c 0.01, *... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))','title':'CD45 Antibody (14-0451-82) in IHC (F)','appAbv':'IHC (F)','dateTime':'May 27, 2021, 4:00:00 AM','appName':'Immunohistochemistry (Frozen)','type':'Published Figures','journalTitle':'Biology','journalText':'Biology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14904_biology-10-00472-g001.jpg','benchSciPubmedId':'34071825'},{'sku':'14-0451-82','imageId':'878708','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14904_biology-10-00472-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14904_biology-10-00472-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14904_biology-10-00472-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14904_biology-10-00472-g004.jpg?time\u003d20240507','sortOrder':'26','description':'Figure 4 Expression of IL-16 by infiltrating immune cells in EAE mice. Spinal cord and brains were harvested from EAE and PBS control mice. Tissue was co-stained with IL-16 (green) and CD45, CD4, or F4/80 (all red). Representative images of spinal cord ( A - C ), cerebellum ( D ) and hippocampus ( E ) tissues are shown. Dotted white lines indicate spinal cord section edges. White arrows indicate areas of colocalization. Percentage of double-positive cells in each group within the spinal cord ( A - C ), hippocampus ( F , G ) and cerebellum ( H , I ) were quantified with results expressed as the mean +- SEM. N \u003d 5. Statistical significance was determined by one-way ANOVA with Bonferroni post hoc tests. * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001 versus PBS or comparison groups are indicated by the bar lines.','shortDescription':'Figure 4 Expression of IL-16 by infiltrating immune cells in EAE mice. Spinal cord and brains were harvested from EAE and PBS control mice. Tissue was co-stained with IL-16 (green) and CD45, CD4, or F4/80 (all red). Representative images of spinal cord ( A - C ), cerebellum ( D ) and hippocampus ( E ) tissues are shown. Dotted white lines indicate spinal cord section edges. White arrows indicate areas of co... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))','title':'CD45 Antibody (14-0451-82) in IHC (F)','appAbv':'IHC (F)','dateTime':'May 27, 2021, 4:00:00 AM','appName':'Immunohistochemistry (Frozen)','type':'Published Figures','journalTitle':'Biology','journalText':'Biology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14904_biology-10-00472-g004.jpg','benchSciPubmedId':'34071825'},{'sku':'14-0451-82','imageId':'335736','imageUrl':'https://www.thermofisher.com/antibody/images/650/CD45_26147083_IF_10_nihms-687095-f0007_20180524.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/CD45_26147083_IF_10_nihms-687095-f0007_20180524.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/CD45_26147083_IF_10_nihms-687095-f0007_20180524.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/CD45_26147083_IF_10_nihms-687095-f0007_20180524.jpg?time\u003d20240507','sortOrder':'27','description':'Extended Data Figure 3 Basal stem/progenitor cell ablation promotes the differentiation of secretory cells into ciliated cells without affecting the mesenchyme a, Immunostaining for YFP lineage label (green) and the ciliated cell marker C-MYB (red) in SCGB1A1-YFP; CK5-DTA mice (n\u003d3 mice). White arrowheads point to double positive cells. b, Immunostaining for YFP lineage label (green) and the ciliated cell marker ACTUB (red) using SCGB1A1-YFP; CK5-DTA mice (n\u003d3 mice). c, Flow cytometry analysis for lineage labeled YFP + cells (x axis) and CD24 + ciliated cells (y axis) cells from control iPBS-treated or Dox-treated SCG1A1-YFP; CK5-DTA mice. d, Quantification of the percentage of FOXJ1 + cells per total DAPI + cells in tracheal sections from control iPBS-treated or iDOX-treated SCG1A1-YFP; CK5-DTA mice (n\u003d3 mice). On the right, absolute numbers of FOXJ1 + cells per tracheal section (n\u003d3 mice). e, H\u0026E staining of tracheal sections following basal cell ablation. f, Immunostaining for CD45 + hematopoietic cells (left panels), CD31 + endothelial cells (middle panels) and SMA + smooth muscle cells (right panels) (green) in control or basal cell-ablated trachea (n\u003d3 mice). All analyses were performed 3 days after cell ablation. Nuclei stained with DAPI (blue). n\u003dbiological replicates/condition. Two independent experiments. ** p\u003c0.01. Data shown in the graphs are means +- SEM. Scale bar, 20mum.','shortDescription':'Extended Data Figure 3 Basal stem/progenitor cell ablation promotes the differentiation of secretory cells into ciliated cells without affecting the mesenchyme a, Immunostaining for YFP lineage label (green) and the ciliated cell marker C-MYB (red) in SCGB1A1-YFP; CK5-DTA mice (n\u003d3 mice). White arrowheads point to double positive cells. b, Immunostaining for YFP lineage label (green) and the ciliated cell m... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))','title':'CD45 Antibody (14-0451-82) in IHC (F)','appAbv':'IHC (F)','dateTime':'Jul 30, 2015, 4:00:00 AM','appName':'Immunohistochemistry (Frozen)','type':'Published Figures','journalTitle':'Nature','journalText':'Nature 2015 - ','sourceType':'3','benchsci':true,'imageName':'CD45_26147083_IF_10_nihms-687095-f0007_20180524.jpg','benchSciPubmedId':'26147083'},{'sku':'14-0451-82','imageId':'322083','imageUrl':'https://www.thermofisher.com/antibody/images/650/14045182-22363815-CD45-pone0032193g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/14045182-22363815-CD45-pone0032193g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/14045182-22363815-CD45-pone0032193g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/14045182-22363815-CD45-pone0032193g004.jpg?time\u003d20240507','sortOrder':'28','description':'Figure 4 Skin pathology in OX40 Cre Ikbk2 fx/fx mice is not T cell dependent. (A) Photograph shows skin pathology in a representative Rag1 -/- OX40 Cre Ikbk2 fx/fx mouse (fx/fx) compared with a littermate Rag1 -/- OX40 Cre Ikbk2 fx/wt control (fx/wt). White dotted line indicates the border between dermis and epidermis. (B) Images show skin sections from 12-16 week old mice of the indicated strain stained with H\u0026E and taken at 10x magnification. (C) Confocal images of skins sections from 12-16 week old mice of the indicated mice stained for expression of CD45, cytokeratin 5 or cytokeratin 6 (red) and counter stained with DAPI. White scale bar indicates 10 um size. (D) Graph shows progress of disease development in Rag1 -/- OX40 Cre Ikbk2 fx/fx mice (blue, n \u003d 18) as compared with Rag1 sufficient OX40 Cre Ikbk2 fx/fx mice (black lines, n \u003d 9). (E) Bar chart shows mean time of disease progression to score 2 in Rag1 -/- OX40 Cre Ikbk2 fx/fx mice as compared with Rag1 sufficient OX40 Cre Ikbk2 fx/fx mice. Data are representative (A-C) of three independent experiments or are pooled (D-E) from three independent experiments.','shortDescription':'Figure 4 Skin pathology in OX40 Cre Ikbk2 fx/fx mice is not T cell dependent. (A) Photograph shows skin pathology in a representative Rag1 -/- OX40 Cre Ikbk2 fx/fx mouse (fx/fx) compared with a littermate Rag1 -/- OX40 Cre Ikbk2 fx/wt control (fx/wt). White dotted line indicates the border between dermis and epidermis. (B) Images show skin sections from 12-16 week old mice of the indicated strain stained wi... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))','title':'CD45 Antibody (14-0451-82) in IHC (F)','appAbv':'IHC (F)','dateTime':'Jun 29, 2012, 4:00:00 AM','appName':'Immunohistochemistry (Frozen)','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2012 - ','sourceType':'3','benchsci':true,'imageName':'14045182-22363815-CD45-pone0032193g004.jpg','benchSciPubmedId':'22363815'},{'sku':'14-0451-82','imageId':'327482','imageUrl':'https://www.thermofisher.com/antibody/images/650/14045182-22363815-CD45-pone0032193g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/14045182-22363815-CD45-pone0032193g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/14045182-22363815-CD45-pone0032193g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/14045182-22363815-CD45-pone0032193g002.jpg?time\u003d20240507','sortOrder':'29','description':'Figure 2 OX40 Cre Ikbk2 fx/fx mice exhibit skin epidermis hyperplasia. (A) Images show skin sections from 12-16 wk old mice of the indicated strain stained with H\u0026E and taken at 10x magnification. White dotted line indicates the border between dermis and epidermis. (B) Confocal images of skins sections from 12-16 week old mice of the indicated mice stained for expression of CD45, cytokeratin 5 or cytokeratin 6 (red) and counter stained with DAPI. White scale bar indicates 10 um size. Data are representative of 3 independent experiments and at least two mice per strain experiment.','shortDescription':'Figure 2 OX40 Cre Ikbk2 fx/fx mice exhibit skin epidermis hyperplasia. (A) Images show skin sections from 12-16 wk old mice of the indicated strain stained with H\u0026E and taken at 10x magnification. White dotted line indicates the border between dermis and epidermis. (B) Confocal images of skins sections from 12-16 week old mice of the indicated mice stained for expression of CD45, cytokeratin 5 or cytokerati... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))','title':'CD45 Antibody (14-0451-82) in IHC (F)','appAbv':'IHC (F)','dateTime':'Jun 29, 2012, 4:00:00 AM','appName':'Immunohistochemistry (Frozen)','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2012 - ','sourceType':'3','benchsci':true,'imageName':'14045182-22363815-CD45-pone0032193g002.jpg','benchSciPubmedId':'22363815'},{'sku':'14-0451-82','imageId':'952718','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20585_gr4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20585_gr4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20585_gr4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20585_gr4.jpg?time\u003d20240507','sortOrder':'30','description':'Characteristics of the corpus tissue of 6-month-old RUNX3 R122C/R122C mice. ( A ) Representative macroscopic images of the corpus of 6-month-old WT and RUNX3 R122C/R122C mice. ( B ) H\u0026E staining of the corpus of 6-month-old WT and RUNX3 R122C/R122C mice. ( C ) IF staining for Atp4a and GSII in the corpus. ( D ) IF staining for GIF, Muc5ac, E-cadherin (E-cad), and chromogranin A (ChgA) in the corpus. ( E ) Quantification of the numbers of parietal, mucous neck, and chief cells per gland in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( F ) qPCR for Muc6 , Atp4a , and Gif expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n \u003d 3 mice each). ( G ) H\u0026E staining of the gland base in 6-month-old WT and RUNX3 R122C/R122C mice. ( H ) IF staining for CD45 and E-cad in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( I ) qPCR for Il6beta and Tnf expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n \u003d 3 mice each). Scale bars : 5 mm ( A ), 100 mum ( B-D , G , and H ). Data are presented as the means +- SEM and were analyzed by the Student t test. * P \u003c .05, *** P \u003c .001. DAPI, 4\u0027,6-diamidino-2-phenylindole.','shortDescription':'Characteristics of the corpus tissue of 6-month-old RUNX3 R122C/R122C mice. ( A ) Representative macroscopic images of the corpus of 6-month-old WT and RUNX3 R122C/R122C mice. ( B ) H\u0026E staining of the corpus of 6-month-old WT and RUNX3 R122C/R122C mice. ( C ) IF staining for Atp4a and GSII in the corpus. ( D ) IF staining for GIF, Muc5ac, E-cadherin (E-cad), and chromogranin A (ChgA) in the corpus. ( E ) Q... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 18, 2022, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Cellular and molecular gastroenterology and hepatology','journalText':'Cellular and molecular gastroenterology and hepatology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20585_gr4.jpg','benchSciPubmedId':'35074568'},{'sku':'14-0451-82','imageId':'952731','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20585_gr5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20585_gr5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20585_gr5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20585_gr5.jpg?time\u003d20240507','sortOrder':'31','description':'Features of the corpus tissue of 6-month-old RUNX3 R122C/R122C mice. ( A ) qPCR for Muc5ac and Chga expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n \u003d 3 mice each). ( B ) IF staining (XZ-section) for Ki67, GSII, and CD45 in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( C and D ) IF staining for ( C ) CD68 and ( D ) F4/80 and E-cad in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( E ) IF staining for F4/80, CD163, and E-cad in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( F ) qPCR for Il1b and Ptgs2 ( Cox-2 ) expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n \u003d 3 mice each). Scale bars : 100 mum ( B , C , and E ), 50 mum ( D ). Data are presented as the means +- SEM and were analyzed by the Student t test. * P \u003c .05. DAPI, 4\u0027,6-diamidino-2-phenylindole.','shortDescription':'Features of the corpus tissue of 6-month-old RUNX3 R122C/R122C mice. ( A ) qPCR for Muc5ac and Chga expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n \u003d 3 mice each). ( B ) IF staining (XZ-section) for Ki67, GSII, and CD45 in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( C and D ) IF staining for ( C ) CD68 and ( D ) F4/80 and E-cad in the corpus ti... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 18, 2022, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Cellular and molecular gastroenterology and hepatology','journalText':'Cellular and molecular gastroenterology and hepatology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20585_gr5.jpg','benchSciPubmedId':'35074568'},{'sku':'14-0451-82','imageId':'876863','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'32','description':'Fig. 1 Isolation and characterization of mesenchymal stem cells. a Schematic showing isolation of mouse bone marrow cells (BMCs) and its properties of self-renewal and differentiation of MSCs. b Representative microscopic images displaying isolated bone marrow cells that show circular and round-shaped morphology of BMCs; whereas, adhered MSCs show fibroblast or eye-shaped morphology. c Immunofluorescence images of MSCs showing the expression of MSC-positive markers (CD29, CD44, and SCA1). d Immunophenotypic characterization of MSCs using flow cytometer showing the absolute counts of MSC positive markers such as CD29, CD44, and SCA1, as well as expression of MSC-negative (CD34, CD45, and CD11b). Isotype controls for each antibody were used as controls and FITC/rhodamine-conjugated secondary antibodies were used for their detection. e Bar graph (quantification from four independent experiments (expressed as mean +- standard error)) showing the percentage of cells expressing the MSC-positive and negative markers respectively. f , g Immunophenotypic characterization of BMCs using flow cytometer showing expression various markers (CD29, CD44, CD45, and CD11b). Bar graph expressed as mean +- standard error shows quantification of respective markers from three independent experiments.','shortDescription':'Fig. 1 Isolation and characterization of mesenchymal stem cells. a Schematic showing isolation of mouse bone marrow cells (BMCs) and its properties of self-renewal and differentiation of MSCs. b Representative microscopic images displaying isolated bone marrow cells that show circular and round-shaped morphology of BMCs; whereas, adhered MSCs show fibroblast or eye-shaped morphology. c Immunofluorescence im... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)','title':'CD45 Antibody (14-0451-82) in IHC, Flow','appAbv':'Flow','dateTime':'Oct 20, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'NPJ Regenerative medicine','journalText':'NPJ Regenerative medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15066_41536_2021_180_Fig1_HTML.jpg','benchSciPubmedId':'34671058'},{'sku':'14-0451-82','imageId':'952696','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20583_urn-x-wiley-02709139-media-hep32083-hep32083-fig-0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20583_urn-x-wiley-02709139-media-hep32083-hep32083-fig-0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20583_urn-x-wiley-02709139-media-hep32083-hep32083-fig-0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20583_urn-x-wiley-02709139-media-hep32083-hep32083-fig-0005.jpg?time\u003d20240507','sortOrder':'33','description':'5 FIG. Sab knockdown prevents decreased energy expenditure, hepatic inflammation, and fibrosis. Feeding and ASO as in Fig . 4. (A) Immunoblot of JNK, p38, ATF2, and MKK4 and phospho-forms, and Col1alpha. beta-actin is the loading control. Each line represents a single mouse liver (n \u003d 4 mice/group). Representative images of three separate blots. Regression plot of EE (B,C) and residual EE (D,E) before and after ASO treatment of the same mice. Regression plot of residual EE against fat mass. Mean values of residual EE are shown as (Delta). # P \u003c 0.05 EE in HFHC versus chow-fed groups. * P \u003c 0.05 EE of mice after versus before ASO treatment by ANCOVA (n \u003d 5-6 mice/group). (F) Representative immunohistochemistry of liver sections from Control-ASO ( Ctl-ASO ) or Sab-ASO treated mice fed the HFHC diet for 30 weeks. CD45, CD68, MPO, F4/80, TNF, and alpha-SMA stained in formalin-fixed paraffin-embedded tissue sections and color developed by DAB substrate (n \u003d 5-6 mice/group). Scale bar \u003d 100 um.','shortDescription':'5 FIG. Sab knockdown prevents decreased energy expenditure, hepatic inflammation, and fibrosis. Feeding and ASO as in Fig . 4. (A) Immunoblot of JNK, p38, ATF2, and MKK4 and phospho-forms, and Col1alpha. beta-actin is the loading control. Each line represents a single mouse liver (n \u003d 4 mice/group). Representative images of three separate blots. Regression plot of EE (B,C) and residual EE (D,E) before and a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Dec 1, 2021, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Hepatology (Baltimore, Md.)','journalText':'Hepatology (Baltimore, Md.) 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20583_urn-x-wiley-02709139-media-hep32083-hep32083-fig-0005.jpg','benchSciPubmedId':'34331779'},{'sku':'14-0451-82','imageId':'932197','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19135_urn-x-wiley-00223417-media-path5768-path5768-fig-0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19135_urn-x-wiley-00223417-media-path5768-path5768-fig-0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19135_urn-x-wiley-00223417-media-path5768-path5768-fig-0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19135_urn-x-wiley-00223417-media-path5768-path5768-fig-0002.jpg?time\u003d20240507','sortOrder':'34','description':'2 Figure LEC-specific mTOR deletion results in elevated numbers of F4/80+ macrophages in the liver. (A) IHC for F4/80 and CD45 in liver sections from WT and mTOR LEC mice (scale bar \u003d 100 mum). (B) Positive cells were counted using ImageJ software, normalized to number of cells per field of view and shown as bar charts. Mean +- SEM, statistically analyzed using unpaired two-sided Student\u0027s t- test, *** p \u003c 0.001.','shortDescription':'2 Figure LEC-specific mTOR deletion results in elevated numbers of F4/80+ macrophages in the liver. (A) IHC for F4/80 and CD45 in liver sections from WT and mTOR LEC mice (scale bar \u003d 100 mum). (B) Positive cells were counted using ImageJ software, normalized to number of cells per field of view and shown as bar charts. Mean +- SEM, statistically analyzed using unpaired two-sided Student\u0027s t- test, *** p \u003c ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Nov 1, 2021, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'The Journal of pathology','journalText':'The Journal of pathology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19135_urn-x-wiley-00223417-media-path5768-path5768-fig-0002.jpg','benchSciPubmedId':'34309874'},{'sku':'14-0451-82','imageId':'879451','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15188_ijms-22-05800-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15188_ijms-22-05800-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15188_ijms-22-05800-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15188_ijms-22-05800-g003.jpg?time\u003d20240507','sortOrder':'35','description':'Figure 3 C3-/- mice show enhanced infiltration of leukocytes. ( a ) The scatter plot shows leukocytes (CD45 + ) per mm 2 in ischemic gastrocnemius muscles isolated at day 7 after FAL. Data shown are means +- SEM, n \u003d 5 per group, a defined ischemic area (1.5 mm 2 ) of muscle tissue was analyzed per mouse. **** p \u003c 0.0001 (WT vs. C3-/-) by unpaired Student\u0027s t -test. ( b ) Representative immunofluorescence pictures of analyzed gastrocnemius muscles of WT (upper picture) and C3-/- mice (lower picture) 7 days after FAL. Cells were labeled with antibodies targeting CD45 (green) and with DAPI (blue) to label nuclei. Scale bars: 20 um.','shortDescription':'Figure 3 C3-/- mice show enhanced infiltration of leukocytes. ( a ) The scatter plot shows leukocytes (CD45 + ) per mm 2 in ischemic gastrocnemius muscles isolated at day 7 after FAL. Data shown are means +- SEM, n \u003d 5 per group, a defined ischemic area (1.5 mm 2 ) of muscle tissue was analyzed per mouse. **** p \u003c 0.0001 (WT vs. C3-/-) by unpaired Student\u0027s t -test. ( b ) Representative immunofluorescence p... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'May 28, 2021, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15188_ijms-22-05800-g003.jpg','benchSciPubmedId':'34071589'},{'sku':'14-0451-82','imageId':'876222','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15186_40478_2021_1186_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15186_40478_2021_1186_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15186_40478_2021_1186_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15186_40478_2021_1186_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'36','description':'Fig. 1 VISTA is differentially expressed in distinct MS lesion stages and decreases in EAE. a Representative images of in situ expression of VISTA in distinct MS lesion stages. b Quantification of the area positive for VISTA in MS lesion stages compared to normal-appearing regions shown as log fold change. At least 3 images were taken from each lesion and the area positive for VISTA was measured. Statistical analysis performed was a Wilcoxon signed-rank test comparing lesions to normal-appearing areas with Benjamini-Hochberg correction for multiple comparisons (n \u003d 5 for each lesion). (c) VISTA geometric mean fluorescence intensity (gMFI) on viable (DAPIneg) microglia (CD45intCD11BposLY6Cneg) during different stages of EAE including score 1(E1: early disease) score 4 (E4: peak disease), and chronic EAE (Ech), and unimmunized control (c) mice. Error bars indicate mean +- s.d. (n \u003d 5-6). Statistical analysis performed was a one-way ANOVA with Dunnett\u0027s correction for multiple comparisons. d Fold change in VISTA expression in primary neonatal mouse microglia 5 h after stimulation with LPS, Pam3CSK4, PolyI:C, myelin, IL1b, or TNFa, measured by RT-qPCR and normalized to Hprt1. Error bars indicate mean +- s.d. (n \u003d 3-5). Statistical analysis performed was a one-way ANOVA with Dunnett\u0027s correction for multiple comparisons. Boxes indicate median and lower and upper quartiles, whiskers show min/max, and outliers are indicated by points. ns \u003d not significant, * p \u003c 0.05, ** p \u003c 0.01, *','shortDescription':'Fig. 1 VISTA is differentially expressed in distinct MS lesion stages and decreases in EAE. a Representative images of in situ expression of VISTA in distinct MS lesion stages. b Quantification of the area positive for VISTA in MS lesion stages compared to normal-appearing regions shown as log fold change. At least 3 images were taken from each lesion and the area positive for VISTA was measured. Statistica... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'May 18, 2021, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Acta neuropathologica communications','journalText':'Acta neuropathologica communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15186_40478_2021_1186_Fig1_HTML.jpg','benchSciPubmedId':'34006329'},{'sku':'14-0451-82','imageId':'843468','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12874_biomedicines-09-00395-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12874_biomedicines-09-00395-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12874_biomedicines-09-00395-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12874_biomedicines-09-00395-g003.jpg?time\u003d20240507','sortOrder':'37','description':'Figure 3 Cold-inducible RNA-binding protein (CIRP) knockout decreases leukocyte infiltration in ischemic tissue. ( a ) The scatter plot displays the relative amount of CD45+ (pan-leukocyte marker) cells (per mm 2 ) of ischemic gastrocnemius muscles of wildtype and CIRP -/- mice 7 days after femoral artery ligation (FAL). Data are means +- S.E.M., n \u003d 5 per group. * p \u003c 0.05 (CIRP -/- vs. control) by unpaired, two-sided student\u0027\u0027s t-test. ( b ) Representative immunofluorescence stainings of ischemic gastrocnemius muscles of CIRP wildtype control (left) and CIRP -/- (right) mice 7 days after FAL. Smaller images display single channels, large images merged channels of leukocytes (anti-CD45, green) and nucleic acid (DAPI, blue) stains. Scale bars 50 um.','shortDescription':'Figure 3 Cold-inducible RNA-binding protein (CIRP) knockout decreases leukocyte infiltration in ischemic tissue. ( a ) The scatter plot displays the relative amount of CD45+ (pan-leukocyte marker) cells (per mm 2 ) of ischemic gastrocnemius muscles of wildtype and CIRP -/- mice 7 days after femoral artery ligation (FAL). Data are means +- S.E.M., n \u003d 5 per group. * p \u003c 0.05 (CIRP -/- vs. control) by unpaire... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 7, 2021, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Biomedicines','journalText':'Biomedicines 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12874_biomedicines-09-00395-g003.jpg','benchSciPubmedId':'33916904'},{'sku':'14-0451-82','imageId':'933502','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19145_gutjnl-2020-321112f06.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19145_gutjnl-2020-321112f06.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19145_gutjnl-2020-321112f06.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19145_gutjnl-2020-321112f06.jpg?time\u003d20240507','sortOrder':'38','description':'Figure 6 Elimination of senescent cells blocks PanIN development and reduces PDAC incidence. (A) Timeline of caerulein and repeated ABT-737 treatments during PanIN and PDAC formation period. ABT-737 was administered for 2 days every month, for four consecutive months, and mice were either sacrificed after the last treatment (point 1), or maintained for a further 3.5 months (point 2). (B) Representative images of pancreatic sections from time point one stained for CK19, SA-betaGal and CD45, labelling hematopoietic cells. (C) Percentage of tissue area containing ADM and PanIN lesions in mice treated with ABT-737 (n\u003d6) or vehicle (n\u003d3). Values indicate mean per group +-SE. (D) Levels of cytokines and chemokines in pancreata of Pdx1-Cre +/- ; LSL-Kras +/G12D mice treated with ABT-737, as measured by cytokine array. Values are shown relative to levels in vehicle-treated mice (pool of 3 mice per group). (E) Percentages of mice treated with ABT-737 or with vehicle that showed PDAC formation upon sacrifice at time point 2. Images show representative whole pancreas from mice in each group. Arrow indicates a large PDAC lesion. *P\u003c0.05, chi 2 test between ABT-737 and vehicle treated groups. (F) Pancreas to body-weight ratio in same mice as in (E). Values indicate mean across mice +-SE, n numbers as in (E). (G) Representative images of pancreatic sections from time point two stained as indicated. (H) Percentage of tissue area occupied by ADM, PanINs or PDAC in the same mice. *P\u003c0.05, t t','shortDescription':'Figure 6 Elimination of senescent cells blocks PanIN development and reduces PDAC incidence. (A) Timeline of caerulein and repeated ABT-737 treatments during PanIN and PDAC formation period. ABT-737 was administered for 2 days every month, for four consecutive months, and mice were either sacrificed after the last treatment (point 1), or maintained for a further 3.5 months (point 2). (B) Representative imag... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Feb 1, 2022, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Gut','journalText':'Gut 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19145_gutjnl-2020-321112f06.jpg','benchSciPubmedId':'33649045'},{'sku':'14-0451-82','imageId':'879329','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15170_12974_2020_2060_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15170_12974_2020_2060_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15170_12974_2020_2060_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15170_12974_2020_2060_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'39','description':'Fig. 3 USUV isolates differentially induce cellular infiltration, apoptosis, and inflammation in the mice brain. a Left panel: Immunohistochemical CD45 staining (associated with luxol blue) showing inflammatory infiltrates in the infected brain (brown staining) at 6 dpi. Some cells present caspase 3 staining after immunohistochemistry. Right panel: Quantification of CD45-positive cells and caspase 3 positive cells in USUV-infected brain compared to CT. b qRT-PCR analysis of TNFalpha, IL6, IFNbeta, and IL1beta mRNA from the brain collected at 6 dpi. Each histogram represents the mean +- SEM from 6 independent mice normalized to CT. * p \u003c 0.05 and ** p \u003c 0.01','shortDescription':'Fig. 3 USUV isolates differentially induce cellular infiltration, apoptosis, and inflammation in the mice brain. a Left panel: Immunohistochemical CD45 staining (associated with luxol blue) showing inflammatory infiltrates in the infected brain (brown staining) at 6 dpi. Some cells present caspase 3 staining after immunohistochemistry. Right panel: Quantification of CD45-positive cells and caspase 3 positiv... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Jan 6, 2021, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15170_12974_2020_2060_Fig3_HTML.jpg','benchSciPubmedId':'33407600'},{'sku':'14-0451-82','imageId':'843370','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12870_pntd.0008223.g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12870_pntd.0008223.g007.jpg?time\u003d20240507','sortOrder':'40','description':'Fig 7 USUV induces strong inflammatory responses in mouse eyes and efficiently replicates in human retinal pigment epithelium. (A) Representative photograph demonstrating ocular pathology and exudate in Ifnar -/- mice inoculated intraperitoneally with USUV at 10 4 TCID50/mouse. (B) Histological sections of uninfected (CT) or USUV-infected (6 dpi) neonatal mouse eye stained with haematoxylin/eosin/saffron and (C) immunohistochemical CD45 staining showing inflammatory infiltrates in neonatal eyes. Disruption of both inner and outer retinal structure and loss of photoreceptors layer were observed. INL: inner nuclear layer. ONL: outer nuclear layer. PL: photoreceptors layer. (D) Immunofluorescence staining shows microglia recruitment/activation in eyes of infected mice (Iba1: purple, nuclei: false colored green). Scale bar \u003d 50mum. (E) qRT-PCR analysis of CXCL10, CCL5, IL6, IFNalpha and TNFalpha mRNA collected at 6 dpi from eyes of control and infected mice. *p \u003c0 .05. (F) IPSC-derived-RPE were infected with USUV at MOI 0.2. Viral titers from apical and basolateral compartments of RPE grown on cell culture inserts were measured at 4 dpi and 7 dpi. Results are expressed as mean +- SEM of 3 independent experiments. (G) Fold regulation of statistically significant genes modulated at 2 dpi normalized to CT in USUV-infected RPE by qRT-PCR analysis using a specific interferons and receptors PCR array. Results are expressed as means of the fold regulation for 3 independent experiments a','shortDescription':'Fig 7 USUV induces strong inflammatory responses in mouse eyes and efficiently replicates in human retinal pigment epithelium. (A) Representative photograph demonstrating ocular pathology and exudate in Ifnar -/- mice inoculated intraperitoneally with USUV at 10 4 TCID50/mouse. (B) Histological sections of uninfected (CT) or USUV-infected (6 dpi) neonatal mouse eye stained with haematoxylin/eosin/saffron an... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 1, 2020, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'PLoS neglected tropical diseases','journalText':'PLoS neglected tropical diseases 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12870_pntd.0008223.g007.jpg','benchSciPubmedId':'32324736'},{'sku':'14-0451-82','imageId':'843346','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12870_pntd.0008223.g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12870_pntd.0008223.g004.jpg?time\u003d20240507','sortOrder':'41','description':'Fig 4 USUV induces massive brain inflammation. Histological sections of neonatal brain mice infected by USUV (6 dpi). (A) Immunohistochemical staining of B-cells (PAX 5), T-cells (CD3) and macrophages (F4/F80) showing T-cells and macrophages infiltration. (B) Immunofluorescence staining (Iba1 in pink, nucleus in green) shows microglia recruitment/activation in USUV-infected brain contrary to control mice (CT). (C) RT-qPCR analysis using a specific inflammatory cytokines and receptors PCR array of mRNA collected at 6 dpi from brain of control and infected mice. Fold regulation of statistically significant genes normalized to CT are indicated for 3 mice of each group. p \u003c0.05 (p value in S3A Fig ). Scale bar \u003d 50mum. (D) CXCL10 protein level in control and infected mice. (E) Representative picture of dissected brain from EB-injected mock- and USUV- infected mice at 3 and 6 dpi showing no blue labelling. Liver is used as positive control of EB staining.','shortDescription':'Fig 4 USUV induces massive brain inflammation. Histological sections of neonatal brain mice infected by USUV (6 dpi). (A) Immunohistochemical staining of B-cells (PAX 5), T-cells (CD3) and macrophages (F4/F80) showing T-cells and macrophages infiltration. (B) Immunofluorescence staining (Iba1 in pink, nucleus in green) shows microglia recruitment/activation in USUV-infected brain contrary to control mice (C... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 1, 2020, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'PLoS neglected tropical diseases','journalText':'PLoS neglected tropical diseases 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12870_pntd.0008223.g004.jpg','benchSciPubmedId':'32324736'},{'sku':'14-0451-82','imageId':'843334','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12870_pntd.0008223.g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12870_pntd.0008223.g003.jpg?time\u003d20240507','sortOrder':'42','description':'Fig 3 USUV induces apoptosis and cellular infiltration in the mouse brain. ( A) Transverse sections of the brain (thalamus) of USUV-infected and control (mock, PBS injected) mice at 6 dpi stained with haematoxylin/eosin/saffron. We observe cellular infiltration and cell shrinkage. CT \u003d control mice. (B) Some cells present nuclear condensation and caspase 3 staining after immunohistochemistry, suggesting apoptotic process in USUV-infected mice. Right panel: zoom on apoptotic cell. Arrows indicate apoptotic cells. (C) Immunohistochemical CD45 staining (associated with luxol blue) showing massive inflammatory infiltrates in multiple areas of the infected brain. (D) Quantification of CD45 positive cells in different brain area. Cor: Cortex, Cer: Cerebellum, Hyp: Hypothalamus, Hip: Hippocampus, Str: Striatum, Tha: Thalamus. (E) Immunohistochemical staining of viral antigen and CD45. The majority of infected cells are not inflammatory cells.','shortDescription':'Fig 3 USUV induces apoptosis and cellular infiltration in the mouse brain. ( A) Transverse sections of the brain (thalamus) of USUV-infected and control (mock, PBS injected) mice at 6 dpi stained with haematoxylin/eosin/saffron. We observe cellular infiltration and cell shrinkage. CT \u003d control mice. (B) Some cells present nuclear condensation and caspase 3 staining after immunohistochemistry, suggesting apo... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 1, 2020, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'PLoS neglected tropical diseases','journalText':'PLoS neglected tropical diseases 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12870_pntd.0008223.g003.jpg','benchSciPubmedId':'32324736'},{'sku':'14-0451-82','imageId':'843358','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12870_pntd.0008223.g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12870_pntd.0008223.g006.jpg?time\u003d20240507','sortOrder':'43','description':'Fig 6 USUV induces spinal cord inflammation. (A) Immunofluoresence of control (CT) and USUV-infected spinal cords of Swiss mice at 6 dpi. The virus is labeled using a pan-flavivirus antibody (green) and nuclei by DAPI (blue). Scale bar \u003d 20 mum. (B) Immunofluoresence CD45 staining showing inflammatory infiltrates in infected-spinal cord (C) not associated with USUV staining (adjacent sections). Scale bar \u003d 15 mum in panel B and 50 mum in panel C. (D) Immunofluoresence caspase 3 staining showing apoptosis in infected-spinal cord. Arrows indicate apoptotic cells. Scale bar \u003d 20 mum. (E) RT-qPCR analysis using a specific inflammatory cytokines and receptors PCR array of mRNA collected at 6 dpi from the spinal cord of control and infected mice. Fold regulation of statistically significant genes normalized to CT are indicated for 3 mice in each group. p \u003c0.05 (p value in S3B Fig ).','shortDescription':'Fig 6 USUV induces spinal cord inflammation. (A) Immunofluoresence of control (CT) and USUV-infected spinal cords of Swiss mice at 6 dpi. The virus is labeled using a pan-flavivirus antibody (green) and nuclei by DAPI (blue). Scale bar \u003d 20 mum. (B) Immunofluoresence CD45 staining showing inflammatory infiltrates in infected-spinal cord (C) not associated with USUV staining (adjacent sections). Scale bar \u003d ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 1, 2020, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'PLoS neglected tropical diseases','journalText':'PLoS neglected tropical diseases 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12870_pntd.0008223.g006.jpg','benchSciPubmedId':'32324736'},{'sku':'14-0451-82','imageId':'855494','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9912_41467_2020_15129_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9912_41467_2020_15129_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9912_41467_2020_15129_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9912_41467_2020_15129_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'44','description':'Fig. 4 cGAS-STING pathway is essential for TMZ and anti-CD47 induced immune response. a Combination TMZ and anti-CD47 antibody treatment against murine GBM cells (GL261) increased the production of type I interferons in APCs. IFNA interferon alpha , IFNB interferon beta . n \u003d 5, ** p \u003c 0.01, one-side ANOVA with Bonferroni post hoc correction. b Western blot showing combined TMZ and anti-CD47 antibody treatment resulted in the activation of cGAS-STING cytoplasmic DNA sensing pathways in BM APCs. c Combination TMZ and anti-CD47 antibody treatment promoted p65 expression and nuclear translocation in BM APCs that is dependent on STING. d STING activation is critical to the increased the production of NF-kappaB cytokine TNFalpha and IL1beta in APCs in the setting of combined TMZ and anti-CD47 antibody treatment. n \u003d 6, ** p \u003c 0.01, unpaired Student\u0027\u0027s t test. e Immunofluorescence staining of GL261 tumors implanted in WT and STING KO animals. Nuclear p-IRF3 (Ser 396) in CD45 + cells is indicative of STING signaling activation. f , g Quantification of CD45 + cell infiltration and percentage of p-IRF3 positive CD45 + , C57BL/6, n \u003d 7; knockout, n \u003d 6. Unpaired Student\u0027\u0027s t test. h GL261 tumor volume in C57BL/6 or STING KO mice at day 20 following control or combination TMZ + aCD47 treatment, n \u003d 5/group. i T-cell infiltration in GL261 tumors in C57BL/6 or STING KO mice at day 20 following control or combination TMZ + aCD47 treatment measured by CD3 + cells in total DAPI count per fie','shortDescription':'Fig. 4 cGAS-STING pathway is essential for TMZ and anti-CD47 induced immune response. a Combination TMZ and anti-CD47 antibody treatment against murine GBM cells (GL261) increased the production of type I interferons in APCs. IFNA interferon alpha , IFNB interferon beta . n \u003d 5, ** p \u003c 0.01, one-side ANOVA with Bonferroni post hoc correction. b Western blot showing combined TMZ and anti-CD47 antibody treatm... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Mar 20, 2020, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9912_41467_2020_15129_Fig4_HTML.jpg','benchSciPubmedId':'32198351'},{'sku':'14-0451-82','imageId':'726884','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_6006_elife-48448-fig3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_6006_elife-48448-fig3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_6006_elife-48448-fig3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_6006_elife-48448-fig3.jpg?time\u003d20240507','sortOrder':'45','description':'Figure 3. The MC903 model induces rapid and robust changes in neuronal tissue. ( A ) Exact permutation test (10,000 iterations, see Materials and methods) for significance of mean absolute log 2 fold change in gene expression at Day 8 (MC903 vs. ethanol) of custom-defined groups of genes for indicated categories (see Figure 3--source data 1 ). ( B ) Log 2 fold change in gene expression (MC903 vs. ethanol) in mouse trigeminal ganglia (TG) at indicated time points for all genes which were significantly differentially expressed for at least one time point in the MC903 model. Green bars \u003d increased expression in MC903 relative to ethanol; magenta \u003d decreased expression. Exact values and corrected p -values are reported in Figure 3--source data 2 and Source Data 1 Supplemental Data, respectively. ( C ) Representative composite images showing immune cells (CD45, green), and sensory neurons (Prph, magenta) with DAPI (blue) in sectioned trigeminal ganglia from mice treated with Vehicle or MC903 for five days on the cheek. ( D ) Quantification of images examining average number of CD45 + cells per section and average ratio of CD45:Peripherin cells per section after five days of treatment (p\u003d0.562 ( t \u003d 0.6318, df \u003d 4), 0.542 ( t \u003d 0.6660, df \u003d 4); two-tailed unpaired t-tests, n \u003d 33-159 fields of view (images) each of both trigeminal ganglia from three mice per condition treated bilaterally). ( E ) Representative composite images showing immune cells (CD45, green), and sensory neurons','shortDescription':'Figure 3. The MC903 model induces rapid and robust changes in neuronal tissue. ( A ) Exact permutation test (10,000 iterations, see Materials and methods) for significance of mean absolute log 2 fold change in gene expression at Day 8 (MC903 vs. ethanol) of custom-defined groups of genes for indicated categories (see Figure 3--source data 1 ). ( B ) Log 2 fold change in gene expression (MC903 vs. ethanol) i... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Oct 21, 2019, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_6006_elife-48448-fig3.jpg','benchSciPubmedId':'31631836'},{'sku':'14-0451-82','imageId':'520636','imageUrl':'https://www.thermofisher.com/antibody/images/650/pone.0206539.g002-20-20190221105219.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/pone.0206539.g002-20-20190221105219.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/pone.0206539.g002-20-20190221105219.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/pone.0206539.g002-20-20190221105219.jpg?time\u003d20240507','sortOrder':'46','description':'Fig 2 Morphology of serially transplanted cervical cancer PDXs. A) representative example of an H\u0026E stained cervical squamous cell carcinoma sample showing morphology of the tumour biopsy, primary, secondary and tertiary PDXs. B) Typical examples of negative staining for anti-human CD45 staining (second column), and anti-mouse CD45 (third column). Insets show examples of CD45 positive staining in human cervix biopsies and mouse kidney Scale bars 50 mum.','shortDescription':'Fig 2 Morphology of serially transplanted cervical cancer PDXs. A) representative example of an H\u0026E stained cervical squamous cell carcinoma sample showing morphology of the tumour biopsy, primary, secondary and tertiary PDXs. B) Typical examples of negative staining for anti-human CD45 staining (second column), and anti-mouse CD45 (third column). Insets show examples of CD45 positive staining in human c... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Mar 29, 2019, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2019 - ','sourceType':'3','benchsci':true,'imageName':'pone.0206539.g002-20-20190221105219.jpg','benchSciPubmedId':'30365542'},{'sku':'14-0451-82','imageId':'855204','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9900_F1.small.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9900_F1.small.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9900_F1.small.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9900_F1.small.jpg?time\u003d20240507','sortOrder':'47','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Sep 28, 2018, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'The Journal of biological chemistry','journalText':'The Journal of biological chemistry 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9900_F1.small.jpg','benchSciPubmedId':'30111591'},{'sku':'14-0451-82','imageId':'842450','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12744_jci-128-97720-g330.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12744_jci-128-97720-g330.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12744_jci-128-97720-g330.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12744_jci-128-97720-g330.jpg?time\u003d20240507','sortOrder':'48','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Jul 2, 2018, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'The Journal of clinical investigation','journalText':'The Journal of clinical investigation 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12744_jci-128-97720-g330.jpg','benchSciPubmedId':'29911993'},{'sku':'14-0451-82','imageId':'520633','imageUrl':'https://www.thermofisher.com/antibody/images/650/41388_2018_313_Fig3_HTML-20-20190221105219.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/41388_2018_313_Fig3_HTML-20-20190221105219.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/41388_2018_313_Fig3_HTML-20-20190221105219.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/41388_2018_313_Fig3_HTML-20-20190221105219.jpg?time\u003d20240507','sortOrder':'49','description':'Fig. 3 Par3 and aPKClamda control carcinogen-induced inflammatory signaling but not early immune cell recruitment. a Quantification of immunofluorescence analysis as previously described (2B) for p-p65 (S468) (Cell Signaling Techn. #3039) on paraffin sections of mice 24 h after DMBA treatment (% of DAPI positive cell nuclei; mean +- SEM; * p \u003c 0.05, ** p \u003c 0.01; one-way ANOVA/Tukey\u0027s post-hoc test). b Quantification of western blot analysis for total p65 protein in epidermal lysates of mice 24 h after DMBA treatment (mean +- SEM; * p \u003c 0.05, ** p \u003c 0.01; one-way ANOVA/Tukey\u0027s post-hoc test). Sample preparation and western blot analysis was performed as previously described [ 17 ]. c Quantification of immunofluorescence analysis as previously described (2B) for p-STAT3 (Y705) (Cell Signaling Techn. #9145) on paraffin sections of short-term DMBA/TPA treated mice (% of DAPI positive cell nuclei; mean + SEM; ** p \u003c 0.01, *** p \u003c 0.001; P58: n ( Cre ctrl) \u003d 5, n ( Par3 eKO) \u003d 4, n ( aPKClamda eKO) \u003d 3, n (edKO) \u003d 5; 24 h post-DMBA: n ( Cre ctrl) \u003d 3, n ( Par3 eKO) \u003d 4, n ( aPKClamda eKO) \u003d 4, n (edKO) \u003d 3; short-term DMBA/TPA: n ( Cre ctrl) \u003d 5, n ( Par3 eKO) \u003d 5, n ( aPKClamda eKO) \u003d 4, n (edKO) \u003d 4; one-way ANOVA/Tukey\u0027s post-hoc). For short-term DMBA/TPA treatments, at P58 mice were treated with a single dose of DMBA (40 mug in 200 mul acetone, Sigma) and three applications of TPA (200 mul of 10 -4 M TPA/acetone) at P65, 68 and 72, and killed 2 days a','shortDescription':'Fig. 3 Par3 and aPKClamda control carcinogen-induced inflammatory signaling but not early immune cell recruitment. a Quantification of immunofluorescence analysis as previously described (2B) for p-p65 (S468) (Cell Signaling Techn. #3039) on paraffin sections of mice 24 h after DMBA treatment (% of DAPI positive cell nuclei; mean +- SEM; * p \u003c 0.05, ** p \u003c 0.01; one-way ANOVA/Tukey\u0027s post-hoc test). b ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Sep 1, 2018, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Oncogene','journalText':'Oncogene 2018 - ','sourceType':'3','benchsci':true,'imageName':'41388_2018_313_Fig3_HTML-20-20190221105219.jpg','benchSciPubmedId':'29789715'},{'sku':'14-0451-82','imageId':'488645','imageUrl':'https://www.thermofisher.com/antibody/images/650/dvdy24634-fig-0002-1-20190103084817.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/dvdy24634-fig-0002-1-20190103084817.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/dvdy24634-fig-0002-1-20190103084817.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/dvdy24634-fig-0002-1-20190103084817.jpg?time\u003d20240507','sortOrder':'50','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Jun 1, 2018, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Developmental dynamics : an official publication of the American Association of Anatomists','journalText':'Developmental dynamics : an official publication of the American Association of Anatomists 2018 - ','sourceType':'3','benchsci':true,'imageName':'dvdy24634-fig-0002-1-20190103084817.jpg','benchSciPubmedId':'29665133'},{'sku':'14-0451-82','imageId':'877890','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15160_jnc14220-fig-0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15160_jnc14220-fig-0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15160_jnc14220-fig-0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15160_jnc14220-fig-0005.jpg?time\u003d20240507','sortOrder':'51','description':'Leukocyte infiltration into the perilesional tissue is not altered by DMF . (a) Low power magnification showing the lesion core and the perilesional area in the cerebral cortex of a DMF -treated mouse at 4 dal. Immunohistochemistry using antibodies specific to CD 45 (red) or Iba-1 (green) indicates the presence of double-immunolabeled microglia/macrophages and leukocytes immunolabelled by anti- CD 45 only. The boxed region is shown in higher magnification (b). Arrows depict CD 45 + /Iba-1 - leukocytes at perilesional sites. (c) Increased numbers of CD 45 + leukocytes in the perilesional tissue of DMF - and vehicle-treated mice compared to corresponding tissue regions in sham mice at 4 dal. No significant difference was observed between DMF - and vehicle-treated mice (sham: n \u003d 6 mice, vehicle: n \u003d 10; DMF : n \u003d 10). Scale: 100 mum (a), 50 mum (b). Statistical significance was calculated by Kruskal-Wallis test and values were adjusted for multiple comparisons by Dunn`s test (* p \u003d 0.05).','shortDescription':'Leukocyte infiltration into the perilesional tissue is not altered by DMF . (a) Low power magnification showing the lesion core and the perilesional area in the cerebral cortex of a DMF -treated mouse at 4 dal. Immunohistochemistry using antibodies specific to CD 45 (red) or Iba-1 (green) indicates the presence of double-immunolabeled microglia/macrophages and leukocytes immunolabelled by anti- CD 45 only. ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Dec 1, 2017, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Journal of neurochemistry','journalText':'Journal of neurochemistry 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15160_jnc14220-fig-0005.jpg','benchSciPubmedId':'28921587'},{'sku':'14-0451-82','imageId':'520628','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3398_srep42195-f2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3398_srep42195-f2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3398_srep42195-f2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3398_srep42195-f2.jpg?time\u003d20240507','sortOrder':'52','description':'Figure 2 HC-HA/PTX3 reduces infiltration of inflammatory and immune cells into lacrimal glands of cGVHD mice. Lacrimal glands collected at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3, were sectioned for H \u0026 E staining ( a , b) , scale bar \u003d 50 mum), immunofluorescence staining against CD45 (Red), CD4 (Green), IL-17 (White) ( c , d ), MHC class II (Red) ( f , g ), and DAPI nuclear staining (Blue) ( c - h) , scale bar \u003d 20 mum), and transmission electron microscopy ( i and j) , Ac: acinus; red arrows: infiltrating inflammatory cells; asterisks: capillary; scale bar \u003d 10 mum). Immunostaining for CD45 (red) and cell nuclei (blue) ( k and l) , scale bar \u003d 20 mum). The number of CD45 + cells per field at x200 magnification in the HC-HA/PTX3- and PBS-treated groups were counted at least 5 different field on 4 sections ( m ), ** p \u003d 0.015, N \u003d 4 for each group).','shortDescription':'Figure 2 HC-HA/PTX3 reduces infiltration of inflammatory and immune cells into lacrimal glands of cGVHD mice. Lacrimal glands collected at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3, were sectioned for H \u0026 E staining ( a , b) , scale bar \u003d 50 mum), immunofluorescence staining against CD45 (Red), CD4 (Green), IL-17 (White) ( c , d ), MHC class II (Red) ( f , g ), and DAPI nu... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Feb 6, 2017, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3398_srep42195-f2.jpg','benchSciPubmedId':'28165063'},{'sku':'14-0451-82','imageId':'527378','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3398_srep42195-f5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3398_srep42195-f5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3398_srep42195-f5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3398_srep42195-f5.jpg?time\u003d20240507','sortOrder':'53','description':'Figure 5 HC-HA/PTX3 suppresses inflammation and fibrosis in conjunctiva of cGVHD mice. Conjunctiva harvested at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3, were sectioned for H \u0026 E ( a and b) , Scale bar \u003d 100 mum) and Mallory staining ( c and d ), Scale bar \u003d 100 mum) and immunostaining for CD45 + cells (red) ( e and f ), MHC class II + cells (red) ( g and h ) and HSP47 + activated fibroblasts (green) ( i and j ) for both groups (Scale bar \u003d 50 mum for ( e - h ). The number of HSP47 + cells/field was compared between the two groups ( **p \u003d 0.005, N \u003d 4 for PBS and N \u003d 4 for HC-HA/PTX3).','shortDescription':'Figure 5 HC-HA/PTX3 suppresses inflammation and fibrosis in conjunctiva of cGVHD mice. Conjunctiva harvested at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3, were sectioned for H \u0026 E ( a and b) , Scale bar \u003d 100 mum) and Mallory staining ( c and d ), Scale bar \u003d 100 mum) and immunostaining for CD45 + cells (red) ( e and f ), MHC class II + cells (red) ( g and h ) and HSP47 + ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Feb 6, 2017, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3398_srep42195-f5.jpg','benchSciPubmedId':'28165063'},{'sku':'14-0451-82','imageId':'322937','imageUrl':'https://www.thermofisher.com/antibody/images/650/CD45_28165063_IF_9_srep42195-f4_20180524.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/CD45_28165063_IF_9_srep42195-f4_20180524.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/CD45_28165063_IF_9_srep42195-f4_20180524.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/CD45_28165063_IF_9_srep42195-f4_20180524.jpg?time\u003d20240507','sortOrder':'54','description':'Figure 4 HC-HA/PTX3 suppresses inflammatory cell and fibrocyte infiltration into lacrimal glands of cGVHD mice. Lacrimal glands collected at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3 were sectioned for immunostaining of CD45 (red)/CD34 (green) ( a , d ), CD45 (red)/collagen type I (green) and CD34 white ( b , e ), and CD45 (red)/CXCR4 (green) and CD34 (white) ( c , f ). Scale bar \u003d 20 mum.','shortDescription':'Figure 4 HC-HA/PTX3 suppresses inflammatory cell and fibrocyte infiltration into lacrimal glands of cGVHD mice. Lacrimal glands collected at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3 were sectioned for immunostaining of CD45 (red)/CD34 (green) ( a , d ), CD45 (red)/collagen type I (green) and CD34 white ( b , e ), and CD45 (red)/CXCR4 (green) and CD34 (white) ( c , f ). Sc... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Feb 6, 2017, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2017 - ','sourceType':'3','benchsci':true,'imageName':'CD45_28165063_IF_9_srep42195-f4_20180524.jpg','benchSciPubmedId':'28165063'},{'sku':'14-0451-82','imageId':'363370','imageUrl':'https://www.thermofisher.com/antibody/images/650/CD45_27165837_IF_9_nihms782512f7_20180524.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/CD45_27165837_IF_9_nihms782512f7_20180524.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/CD45_27165837_IF_9_nihms782512f7_20180524.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/CD45_27165837_IF_9_nihms782512f7_20180524.jpg?time\u003d20240507','sortOrder':'55','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Aug 1, 2016, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Kidney international','journalText':'Kidney international 2016 - ','sourceType':'3','benchsci':true,'imageName':'CD45_27165837_IF_9_nihms782512f7_20180524.jpg','benchSciPubmedId':'27165837'},{'sku':'14-0451-82','imageId':'520626','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3018_nihms779554f4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3018_nihms779554f4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3018_nihms779554f4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3018_nihms779554f4.jpg?time\u003d20240507','sortOrder':'56','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry and Flow Cytometry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry and Flow Cytometry','altTag':'CD45 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)','title':'CD45 Antibody (14-0451-82) in IHC, Flow','appAbv':'Flow','dateTime':'Jun 1, 2016, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cells (Dayton, Ohio)','journalText':'Stem cells (Dayton, Ohio) 2016 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3018_nihms779554f4.jpg','benchSciPubmedId':'27068890'},{'sku':'14-0451-82','imageId':'320319','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12862_nihms746518f5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12862_nihms746518f5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12862_nihms746518f5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12862_nihms746518f5.jpg?time\u003d20240507','sortOrder':'57','description':'Figure 5 Increased leukocyte infiltration and inflammation in tumors from PIK3CA- GEMMs (a) Detection of leukocyte subtypes in tumors from PIK3CA -GEMMs and control mice using IHC with CD45, F4/80, Gr1, and CD11b. Scale bar: 50 muM. (b) qRT-PCR examination of inflammatory-related cytokines/chemokines and receptors. Results are averages of triplicate experiments. *p\u003c0.05 (n\u003d6 for each group).','shortDescription':'Figure 5 Increased leukocyte infiltration and inflammation in tumors from PIK3CA- GEMMs (a) Detection of leukocyte subtypes in tumors from PIK3CA -GEMMs and control mice using IHC with CD45, F4/80, Gr1, and CD11b. Scale bar: 50 muM. (b) qRT-PCR examination of inflammatory-related cytokines/chemokines and receptors. Results are averages of triplicate experiments. *p\u003c0.05 (n\u003d6 for each group).','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Sep 1, 2016, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Oncogene','journalText':'Oncogene 2016 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12862_nihms746518f5.jpg','benchSciPubmedId':'26876212'},{'sku':'14-0451-82','imageId':'346118','imageUrl':'https://www.thermofisher.com/antibody/images/650/pnas1517188113sfig03-20180918151446.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/pnas1517188113sfig03-20180918151446.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/pnas1517188113sfig03-20180918151446.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/pnas1517188113sfig03-20180918151446.jpg?time\u003d20240507','sortOrder':'58','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Jan 5, 2016, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Proceedings of the National Academy of Sciences of the United States of America','journalText':'Proceedings of the National Academy of Sciences of the United States of America 2016 - ','sourceType':'3','benchsci':true,'imageName':'pnas1517188113sfig03-20180918151446.jpg','benchSciPubmedId':'26699479'},{'sku':'14-0451-82','imageId':'360634','imageUrl':'https://www.thermofisher.com/antibody/images/650/48045182-26136374-CD45-embr0016-1037-f6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/48045182-26136374-CD45-embr0016-1037-f6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/48045182-26136374-CD45-embr0016-1037-f6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/48045182-26136374-CD45-embr0016-1037-f6.jpg?time\u003d20240507','sortOrder':'59','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Aug 1, 2015, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'EMBO reports','journalText':'EMBO reports 2015 - ','sourceType':'3','benchsci':true,'imageName':'48045182-26136374-CD45-embr0016-1037-f6.jpg','benchSciPubmedId':'26136374'},{'sku':'14-0451-82','imageId':'363325','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_2307_nihms562085f1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_2307_nihms562085f1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_2307_nihms562085f1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_2307_nihms562085f1.jpg?time\u003d20240507','sortOrder':'60','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'May 1, 2014, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Stem cells (Dayton, Ohio)','journalText':'Stem cells (Dayton, Ohio) 2014 - ','sourceType':'3','benchsci':true,'imageName':'tfs_2307_nihms562085f1.jpg','benchSciPubmedId':'24446236'},{'sku':'14-0451-82','imageId':'329919','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12853_pone0052037g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12853_pone0052037g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12853_pone0052037g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12853_pone0052037g001.jpg?time\u003d20240507','sortOrder':'61','description':'Figure 1 Whole mount in situ immunohistochemistry of gd7.5 B6 implantation sites co-stained with PE-CD31 (red) and FITC-CD45 (green). Low power image (A) is a for orientation. The mesometrial side of the uterus is uppermost; the central black region (*) represents the embryonic crypt. More CD31 expression is present mesometrially than anti-mesometrially or in lateral (L) decidua. Images B, D, F are of the same field (represented by the boxed M) of the mesometrial uterus. Images C, E, G are of the same field (represented by the boxed AM) from the anti-mesometrial uterus. Image (B) illustrates the larger, web-like, less linked vessels of the decidua basalis. These are distinctly different to the narrower, more frequently linked anti-mesometrial vessels shown in (C). (B) but not (C) contains high numbers of CD31+ leukocytes. Image (D) shows the enrichment of leukocytes in decidua basalis while image (E) shows that leukocytes present anti-mesometrially are less frequent and more heterogeneous in shape and size. Red and green are merged in images (F) and (G). Image (F) shows that many cells with co-expression of CD31+ and CD45+ are present mesometrially while image (G) shows their absence anti-mesometrially. Magnification bar in (A) is 200 um; in B-G 50 um.','shortDescription':'Figure 1 Whole mount in situ immunohistochemistry of gd7.5 B6 implantation sites co-stained with PE-CD31 (red) and FITC-CD45 (green). Low power image (A) is a for orientation. The mesometrial side of the uterus is uppermost; the central black region (*) represents the embryonic crypt. More CD31 expression is present mesometrially than anti-mesometrially or in lateral (L) decidua. Images B, D, F are of the s... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Jun 25, 2013, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2013 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12853_pone0052037g001.jpg','benchSciPubmedId':'23284862'},{'sku':'14-0451-82','imageId':'357817','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12851_gr6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12851_gr6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12851_gr6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12851_gr6.jpg?time\u003d20240507','sortOrder':'62','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Dec 1, 2012, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'The American journal of pathology','journalText':'The American journal of pathology 2012 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12851_gr6.jpg','benchSciPubmedId':'23036899'},{'sku':'14-0451-82','imageId':'351992','imageUrl':'https://www.thermofisher.com/antibody/images/650/CD11b_22440612_IF_12_nihms361163f1_20180524.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/CD11b_22440612_IF_12_nihms361163f1_20180524.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/CD11b_22440612_IF_12_nihms361163f1_20180524.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/CD11b_22440612_IF_12_nihms361163f1_20180524.jpg?time\u003d20240507','sortOrder':'63','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Apr 4, 2012, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Cell metabolism','journalText':'Cell metabolism 2012 - ','sourceType':'3','benchsci':true,'imageName':'CD11b_22440612_IF_12_nihms361163f1_20180524.jpg','benchSciPubmedId':'22440612'},{'sku':'14-0451-82','imageId':'357808','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12850_nihms264070f4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12850_nihms264070f4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12850_nihms264070f4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12850_nihms264070f4.jpg?time\u003d20240507','sortOrder':'64','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'May 1, 2011, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Cancer immunology, immunotherapy : CII','journalText':'Cancer immunology, immunotherapy : CII 2011 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12850_nihms264070f4.jpg','benchSciPubmedId':'21340652'},{'sku':'14-0451-82','imageId':'487569','imageUrl':'https://www.thermofisher.com/antibody/images/650/nfig003_015-25-20190103084817.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/nfig003_015-25-20190103084817.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/nfig003_015-25-20190103084817.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/nfig003_015-25-20190103084817.jpg?time\u003d20240507','sortOrder':'65','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Sep 1, 2009, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Journal of cellular physiology','journalText':'Journal of cellular physiology 2009 - ','sourceType':'3','benchsci':true,'imageName':'nfig003_015-25-20190103084817.jpg','benchSciPubmedId':'19452445'},{'sku':'14-0451-82','imageId':'351054','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1480_nihms98872f8.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1480_nihms98872f8.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1480_nihms98872f8.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1480_nihms98872f8.jpg?time\u003d20240507','sortOrder':'66','description':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry','altTag':'CD45 Antibody in Immunohistochemistry (IHC)','title':'CD45 Antibody (14-0451-82) in IHC','appAbv':'IHC','dateTime':'Mar 1, 2009, 5:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Hepatology (Baltimore, Md.)','journalText':'Hepatology (Baltimore, Md.) 2009 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1480_nihms98872f8.jpg','benchSciPubmedId':'19085956'},{'sku':'14-0451-82','imageId':'876514','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14977_41467_2021_23197_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14977_41467_2021_23197_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14977_41467_2021_23197_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14977_41467_2021_23197_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'67','description':'Fig. 1 Generation and characterization of a genetic system for specific targeting of cavity macrophages. a Schematic figure showing CD45-Dre mediates Stop cassette removal from Gata6-iCreER and places CreER directly under Gata6 promoter. After tamoxifen (Tam), Cre-loxP recombination labels cells by tdTomato. b Intersectional genetics marks CD45 + GATA6 + cells as tdTomato + . c Schematic figure showing experimental design using cavity macrophage tracing tool CD45-Dre;Gata6-iCreER ( G6Mo-CreER ). d Flow cytometric analysis of the percentage of tdTomato + cells in macrophages from blood, pleural, and peritoneal cavity with or without Tam. e Immunostaining for tdTomato, CD11b, GATA6, F4/80 on dissociated cells from blood, pleural, or peritoneal cavity. Boxed regions are magnified. f Quantification of the percentage of tdTomato + cells in GATA6 + or F4/80 + macrophages. Data are the mean +- SD; n \u003d 5 mice per group. g Quantification of the percentage of GATA6 + or F4/80 + macrophages in tdTomato + cells. Data are the mean +- SD; n \u003d 5 mice per group. h FACS showing the percentage of tdTomato + cells expressing F4/80. i Whole-mount epifluorescence images and immunostaining for CD45 and tdTomato shows no resident tdTomato + macrophages in visceral organs. Each image is representative of 5 individual biological samples. Scale bars, yellow, 1 mm; white, 100 um. Source data are provided as a Source Data file.','shortDescription':'Fig. 1 Generation and characterization of a genetic system for specific targeting of cavity macrophages. a Schematic figure showing CD45-Dre mediates Stop cassette removal from Gata6-iCreER and places CreER directly under Gata6 promoter. After tamoxifen (Tam), Cre-loxP recombination labels cells by tdTomato. b Intersectional genetics marks CD45 + GATA6 + cells as tdTomato + . c Schematic figure showing expe... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))','title':'CD45 Antibody (14-0451-82) in IHC (PFA)','appAbv':'IHC (PFA)','dateTime':'May 17, 2021, 4:00:00 AM','appName':'Immunohistochemistry (PFA fixed)','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14977_41467_2021_23197_Fig1_HTML.jpg','benchSciPubmedId':'34001904'},{'sku':'14-0451-82','imageId':'932874','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19139_biomedicines-09-00157-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19139_biomedicines-09-00157-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19139_biomedicines-09-00157-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19139_biomedicines-09-00157-g005.jpg?time\u003d20240507','sortOrder':'68','description':'Figure 5 Pro-inflammatory phenotype of microglia in the PFC of DAT-/- rats. ( A ) Levels of CNS microglial marker CD45 were unchanged among the three genotypes. Morphometric analysis of Iba1 + cells showed ( B ) an increase in the total length extension of microglial processes of DAT-/- rats, ( C ) while mean maximum radius did not vary among genotypes. ( D ) Number of branches was significantly higher in DAT-/- rats. ( E ) Sholl analysis displayed higher number of intersections in Iba1 + cells in DAT-/- PFC. Individual data points are shown for each group. Data are presented as mean +- SEM, * p \u003c 0.05, ** p \u003c 0.001, *** p \u003c 0.001.','shortDescription':'Figure 5 Pro-inflammatory phenotype of microglia in the PFC of DAT-/- rats. ( A ) Levels of CNS microglial marker CD45 were unchanged among the three genotypes. Morphometric analysis of Iba1 + cells showed ( B ) an increase in the total length extension of microglial processes of DAT-/- rats, ( C ) while mean maximum radius did not vary among genotypes. ( D ) Number of branches was significantly higher in D... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Western Blot (WB)','title':'CD45 Antibody (14-0451-82) in WB','appAbv':'WB','dateTime':'Feb 5, 2021, 5:00:00 AM','appName':'Western Blot','type':'Published Figures','journalTitle':'Biomedicines','journalText':'Biomedicines 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19139_biomedicines-09-00157-g005.jpg','benchSciPubmedId':'33562738'},{'sku':'14-0451-82','imageId':'1139447','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time\u003d20240507','sortOrder':'69','description':'3 Figure RBC-hitchhiking improves neoantigen-specific T-cell response of DNA nanovaccines A Scheme of the immunization procedure of RBC-Nanovaccines. B, C The expression of MHC I in CD11c + DCs and the percentage of CD45 + CD3 + , CD3 + CD4 + , and CD3 + CD8 + T cells in the spleen were analyzed by flow cytometry at the 11 th day after treatment with PBS, Nanovaccines, and RBC-Nanovaccines once or twice. n \u003d 5 animals per group in (C); data were pooled from two independent experiments. D ELISA analysis of the concentration of TNF-alpha, IFN-gamma, and CRP in the peripheral blood of mice after different treatments ( n \u003d 3-5 animals per group). E ELISPOT analysis of IFN-gamma spot-forming. F The corresponding quantification numbers of spots in (E). n \u003d 5 animals per group; data were pooled from two independent experiments. Data information: Data in (C), (D), and (F) are presented as mean +- SD. Statistical significance was calculated by one-way ANOVA with Tukey\u0027s multiple comparison test in (C, D) and two-tailed Student\u0027s t -test in (F). * P \u003c 0.05, ** P \u003c 0.01 and *** P \u003c 0.001. ns means no significant difference. Source data are available online for this figure.','shortDescription':'3 Figure RBC-hitchhiking improves neoantigen-specific T-cell response of DNA nanovaccines A Scheme of the immunization procedure of RBC-Nanovaccines. B, C The expression of MHC I in CD11c + DCs and the percentage of CD45 + CD3 + , CD3 + CD4 + , and CD3 + CD8 + T cells in the spleen were analyzed by flow cytometry at the 11 th day after treatment with PBS, Nanovaccines, and RBC-Nanovaccines once or twice. n ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 11, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'EMBO molecular medicine','journalText':'EMBO molecular medicine 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg','benchSciPubmedId':'37552209'},{'sku':'14-0451-82','imageId':'1020389','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24743_fphar-13-1095757-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24743_fphar-13-1095757-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24743_fphar-13-1095757-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24743_fphar-13-1095757-g002.jpg?time\u003d20240507','sortOrder':'70','description':'FIGURE 2 Alteration of cellular composition in the diseased status of mice and humans. (A,B) Fractions of major cells types in aneurysmal aorta vs. the corresponding normal aorta of humans (A) and mice (B) . (C) Immunofluorescence analysis for SMMHC (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the human vascular media (scale bars: 100 mum). Lu means the lumen side of the vascular wall, and A means the adventitia side of the vascular wall. (D,E) Immunofluorescence analysis for vimentin (white) (D) and CD45 (purple) (E) and overlays with DAPI-labeled nuclei (blue) showing fibroblasts and immune cells in the human aorta (scale bars: 100 mum). (F) Immunostaining for calponin (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the mouse aortic media (scale bars: 100 mum). (G) Immunostaining for vimentin (white) and DAPI overlay in the thoracic and abdominal aorta form mice subjected to 4 weeks of Ang II induction (scale bars: 500 mum). (H) Immunostaining for CD45 (red), CD68 (green), and overlays with DAPI-labeled nuclei (blue) showing macrophages in the mouse aorta (scale bars: 100 mum). (I) Flow cytometry of the proportion of macrophages (F4/80 + CD11B + ), monocytes (LY6C + CD11B + ), and T cells (CD3 + ) in CD45 + immune cells among three groups (n \u003d 3-4, per group).','shortDescription':'FIGURE 2 Alteration of cellular composition in the diseased status of mice and humans. (A,B) Fractions of major cells types in aneurysmal aorta vs. the corresponding normal aorta of humans (A) and mice (B) . (C) Immunofluorescence analysis for SMMHC (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the human vascular media (scale bars: 100 mum). Lu means th... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 2, 2023, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in pharmacology','journalText':'Frontiers in pharmacology 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24743_fphar-13-1095757-g002.jpg','benchSciPubmedId':'36703732'},{'sku':'14-0451-82','imageId':'1020332','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24778_jci-132-160097-g179.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24778_jci-132-160097-g179.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24778_jci-132-160097-g179.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24778_jci-132-160097-g179.jpg?time\u003d20240507','sortOrder':'71','description':'Figure 3 GPR92 deficiency triggers proinflammatory responses and increases the expansion of M1-like IMs. ( A ) Flow cytometry analysis of CD45 + cells in the islets from WT or KO mice on a HFD, n \u003d 6-4/group. ( B ) CD45 and CD11b double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n \u003d 3-4/group. ( C ) F4/80 and CD11c double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n \u003d 3-5/group. ( D ) Immunofluorescence of the pancreas. Scale bars: 20 mum. ( A - D ) Data and images are representative of at least 3 independent experiments. All data are expressed as mean +- SEM. *** P \u003c 0.001, ** P \u003c 0.01, * P \u003c 0.05 by 2-way ANOVA with Bonferroni\u0026apos;s post hoc. ( E ) Top 15 most-relevant, upregulated (red) and downregulated (blue) genes in the islet from WT versus KO mice on a HFD. Mean values from n \u003d 4-5/group. ( F ) Volcano plot of the fold change ( x axis) versus adjusted (adj.) P value ( y axis) of the transcriptomes between the islets from WT and KO mice on a HFD. Genes highlighted in red or blue are based on the thresholds of log 2 fold change \u003e 1 and adj. P \u003c 0.05. ( G ) Pathways of the islets from WT versus KO mice on a HFD that were either activated (red) or repressed (blue) by lack of GPR92. Normalized enrichment score (NES) is represented in log 10 ( P ).','shortDescription':'Figure 3 GPR92 deficiency triggers proinflammatory responses and increases the expansion of M1-like IMs. ( A ) Flow cytometry analysis of CD45 + cells in the islets from WT or KO mice on a HFD, n \u003d 6-4/group. ( B ) CD45 and CD11b double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n \u003d 3-4/group. ( C ) F4/80 and CD11c double-positive cells (Q4) in the islets from WT and KO mice on... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of clinical investigation','journalText':'The Journal of clinical investigation 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24778_jci-132-160097-g179.jpg','benchSciPubmedId':'36066975'},{'sku':'14-0451-82','imageId':'1020370','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g201.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g201.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24779_jciinsight-7-159875-g201.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24779_jciinsight-7-159875-g201.jpg?time\u003d20240507','sortOrder':'72','description':'Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx diaphragms. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45 + CD11b + LY6G - CD64 + F4/80 hi macrophages ( F ) from spironolactone-treated (SPR-treated) and prednisolone-treated (PRD-treated) 4.5-week-old mdx diaphragms compared with vehicle (VEH) controls. n \u003d 6 replicates per group pooled from 2 mice each were used. ( G ) Quantification of myeloid cells, neutrophils (Nphi), infiltrating monocytes (Inf. MO), macrophages (MPhi), CD206 + macrophages (CD206 + ), and F4/80 hi macrophages represented as dot plots for cells per milligram of muscle (Cells/mg). ( H ) Bar graphs with individual data points as percentages of total CD45 + leukocytes (%CD45 + ), CD45 + CD11b + myeloid cells (%CD45 + CD11b + ), or macrophages (%CD45 + CD11b + LY6G - CD64 + ) comparing SPR- and PRD-treated mice with VEH controls. Experimental replicates are denoted by black and gray dots within the graphs. Statistics used were ANOVA with the BKY test * P \u003c\u003d 0.05.','shortDescription':'Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx diaphragms. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 10, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24779_jciinsight-7-159875-g201.jpg','benchSciPubmedId':'36040807'},{'sku':'14-0451-82','imageId':'1020351','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g200.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g200.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24779_jciinsight-7-159875-g200.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24779_jciinsight-7-159875-g200.jpg?time\u003d20240507','sortOrder':'73','description':'Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx quadriceps. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45 + CD11b + LY6G - CD64 + F4/80 hi macrophages ( F ) from spironolactone-treated (SPR-treated) ( n \u003d 13) and prednisolone-treated (PRD-treated) ( n \u003d 13) 4.5-week-old mdx quadriceps compared with vehicle (VEH) ( n \u003d 12) controls. ( G ) Quantification of myeloid cells, neutrophils (Nphi), infiltrating monocytes (Inf. MO), macrophages (MPhi), CD206 + macrophages (CD206 + ), and F4/80 hi macrophages represented as dot plots for cells per milligram of muscle (Cells/mg). ( H ) Bar graphs with individual data points as percentages of total CD45 + leukocytes (%CD45 + ), CD45 + CD11b + myeloid cells (%CD45 + CD11b + ) or macrophages (%CD45 + CD11b + LY6G - CD64 + ) comparing SPR- and PRD-treated mice with VEH controls. Experimental replicates are denoted by black and gray dots within the graphs. Statistics used were ANOVA with the BKY test * P \u003c\u003d 0.05.','shortDescription':'Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx quadriceps. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 10, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24779_jciinsight-7-159875-g200.jpg','benchSciPubmedId':'36040807'},{'sku':'14-0451-82','imageId':'1020256','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time\u003d20240507','sortOrder':'74','description':'1 FIGURE Flow cytometry analysis of the CD11b+ cells. Cells isolated from non-perfused [(a)-(e)] and perfused [(f)-(j)] brains did not show significant differences. [(a), (f)] Histograms showing two CD45-expressing cell populations: CD45 low (microglia) and CD 45 high (possible macrophages). [(b), (g)] Microglia, identified as CD11b+ and CD45 low (Q3), comprised the highest proportion of cells (91.7%-94.5%), whereas a low percentage of potential macrophages (CD11b+/CD45 high, Q2) were observed. [(c), (h)] Forward scatter (FSC) analysis showing a slight smaller size of the CD45 low cells (red) respect to CD45 high (blue) cells. [(d), (i)] CD11b analysis showed a slight lower expression within CD45 low cells (red) respect to CD45 high (blue) cells. [(e), (j)] Forward scatter (FSC) and side scatter (SSC) characteristics of CD11b+/CD45 low (red) and CD11b+/CD45 high (blue) are shown','shortDescription':'1 FIGURE Flow cytometry analysis of the CD11b+ cells. Cells isolated from non-perfused [(a)-(e)] and perfused [(f)-(j)] brains did not show significant differences. [(a), (f)] Histograms showing two CD45-expressing cell populations: CD45 low (microglia) and CD 45 high (possible macrophages). [(b), (g)] Microglia, identified as CD11b+ and CD45 low (Q3), comprised the highest proportion of cells (91.7%-94.5%)... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Glia','journalText':'Glia 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg','benchSciPubmedId':'35943203'},{'sku':'14-0451-82','imageId':'952744','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20586_jciinsight-7-154824-g203.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20586_jciinsight-7-154824-g203.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20586_jciinsight-7-154824-g203.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20586_jciinsight-7-154824-g203.jpg?time\u003d20240507','sortOrder':'75','description':'Therapeutic potential of i.n. afatinib and pemigatinib application in acute EAE. ( A and B ) Clinical course (left) and linear regression analysis (right) of EAE in mice after daily i.n. treatment with vehicle, afatinib ( A ), or pemigatinib ( B ) starting from symptom onset. The experiment was repeated twice. Vehicle (PBS), n \u003d 10; afatinib, n \u003d 10; pemigatinib, n \u003d 10. Data are reported as mean +- SEM. ( C ) Unsupervised clustering t-distributed stochastic neighbor embedding (t-SNE) plot overlaid with cluster and their abundance ( D ) identified by unsupervised PhenoGraph clustering of high-dimensional flow cytometry data obtained from CNS (brain and spinal cord) tissue at peak of disease from mice treated with afatinib ( n \u003d 5) or vehicle ( n \u003d 5). ( E and F ) Quantification ( E ) and scatter plots ( F ) of CD45 - CD11b - , CD45 int CD11b + , CD45 hi CD11b + , and CD45 + CD11b - cell populations in the CNS of mice treated with afatinib ( n \u003d 5) or vehicle ( n \u003d 5) at peak of disease. Two-way ANOVA with Sidak\u0027s multiple comparisons test. ( G ) Significant differences in CNS-resident and -infiltrating cell populations in mice treated with afatinib ( n \u003d 5) or vehicle ( n \u003d 5) at peak of disease, identified by SAM analysis () (FDR cutoff, 0.1). ( H and I ) Intracellular flow cytometry quantification of iNOS, TNF-alpha, and GM-CSF in astrocytes ( H ) and microglia ( I ) in mice treated with afatinib ( n \u003d 5) or vehicle ( n \u003d 5) at peak of disease. ( J ) Relative expression of','shortDescription':'Therapeutic potential of i.n. afatinib and pemigatinib application in acute EAE. ( A and B ) Clinical course (left) and linear regression analysis (right) of EAE in mice after daily i.n. treatment with vehicle, afatinib ( A ), or pemigatinib ( B ) starting from symptom onset. The experiment was repeated twice. Vehicle (PBS), n \u003d 10; afatinib, n \u003d 10; pemigatinib, n \u003d 10. Data are reported as mean +- SEM. ( ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 8, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20586_jciinsight-7-154824-g203.jpg','benchSciPubmedId':'35393953'},{'sku':'14-0451-82','imageId':'1020313','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_21405_jci-132-157338-g101.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_21405_jci-132-157338-g101.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_21405_jci-132-157338-g101.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_21405_jci-132-157338-g101.jpg?time\u003d20240507','sortOrder':'76','description':'Downregulated ZIP8/SIRT1 signaling and decreased renewal capacity of AEC2s from old mouse lungs. ( A ) Flow cytometry analysis to gate out total AEC2s (R2), and ZIP8 expression AEC2s (R3) from lung homologies of young and old mice. ( B ) Percentage of ZIP8 + cells (R3) within total AEC2s ( n \u003d 5-6, ** P \u003c 0.01). ( C ) Number of ZIP8 + cells recovered from young and old mouse lung ( n \u003d 5-6, ** P \u003c 0.01). ( D ) CFE of mouse AEC2s isolated from young and old mouse lungs ( n \u003d 6-7, ** P \u003c 0.01). ( E and F ) Flow cytometry analysis of ZIP8 expression in gated AEC2s cultured with medium only or medium containing 100 muM ZnSO 4 ( n \u003d 6, *** P \u003c 0.001). ( G - J ) 3D organoid culture of AEC2s isolated from lungs of 2.5-, 12-, 14-, and 18-month-old mice with and without 100 muM ZnSO 4 treatment. ( G ) CFE ( n \u003d 3-4, * P \u003c 0.05, *** P \u003c 0.001, **** P \u003c 0.0001 by ANOVA). ( H - J ) Expression of Slc39a8 ( H ), Sftpc ( I ), and Pdpn ( J ) in AEC2s derived from 3D-cultured organoids with and without ZnSO 4 treatment by qPCR ( n \u003d 3-4, * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001, **** P \u003c 0.0001 by ANOVA). ( K ) Violin plots of gene expression in AEC2s from lungs of bleomycin-treated young and old mice. ( L ) IPA pathway analysis of AEC2s from young and old mice on day 4 after bleomycin injury. ( M and N ) CFE of AEC2s from uninjured 10- to 12-week-old young mice treated with SRT1720 ( n \u003d 3-6, ** P \u003c 0.01, **** P \u003c 0.0001 by ANOVA) ( M ) and splitomicin ( n \u003d 5-6, **** P \u003c 0.0001 by ANOVA) ( N','shortDescription':'Downregulated ZIP8/SIRT1 signaling and decreased renewal capacity of AEC2s from old mouse lungs. ( A ) Flow cytometry analysis to gate out total AEC2s (R2), and ZIP8 expression AEC2s (R3) from lung homologies of young and old mice. ( B ) Percentage of ZIP8 + cells (R3) within total AEC2s ( n \u003d 5-6, ** P \u003c 0.01). ( C ) Number of ZIP8 + cells recovered from young and old mouse lung ( n \u003d 5-6, ** P \u003c 0.01). ( ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of clinical investigation','journalText':'The Journal of clinical investigation 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_21405_jci-132-157338-g101.jpg','benchSciPubmedId':'35389887'},{'sku':'14-0451-82','imageId':'952699','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'77','description':'Systematic quality evaluation of clinical-grade IL10-MSCs. A The IL10 protein level in the supernatant of different IL10-MSCs clones (P5-6). MSCs with blank vector transfection were the control. B With the increase in the number of passages, the IL10 secretion gradually decreased in IL10-MSCs, but still sustained a high level. C Morphological characterization of IL10-MSCs (P6) compared with naive MSCs (P6) under light microscopy. D Representative karyotype analysis. Control MSCs (left, P6) and IL10-MSCs (right, P6) both had normal karyotypes. E Flow cytometric analysis showed IL10-MSCs were positive (\u003e 95%) for mesenchymal lineage markers (CD73, CD90, and CD105) and negative (\u003c 2%) for hematopoietic and endothelial markers (CD14, CD19, CD34, CD45, and CD3) as well as for HLA-DR, in accordance with the criteria of clinical-grade MSCs. F1-2 Tumorigenesis analysis showed that there was no tumor formation observed in any SCID mice injected with IL10-MSCs, but tumor was formed in positive control SCID mice with HESCs transplantation. Further H\u0026E staining showed no infiltration of tumor cells at the cell injection site and main organs after IL10-MSC injection. G - I Differentiation potential of IL10-MSCs in adipocytes, osteocytes, and chondrocytes stained with Oil red O, Alizarin Red, and Alcian Blue, respectively. IL10-MSCs maintained multiple lineage potential, but with downregulated adipogenic differentiation capability','shortDescription':'Systematic quality evaluation of clinical-grade IL10-MSCs. A The IL10 protein level in the supernatant of different IL10-MSCs clones (P5-6). MSCs with blank vector transfection were the control. B With the increase in the number of passages, the IL10 secretion gradually decreased in IL10-MSCs, but still sustained a high level. C Morphological characterization of IL10-MSCs (P6) compared with naive MSCs (P6) ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 17, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cellular \u0026 molecular biology letters','journalText':'Cellular \u0026 molecular biology letters 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20584_11658_2022_325_Fig1_HTML.jpg','benchSciPubmedId':'35300585'},{'sku':'14-0451-82','imageId':'1020294','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24777_ppat.1010342.g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24777_ppat.1010342.g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24777_ppat.1010342.g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24777_ppat.1010342.g002.jpg?time\u003d20240507','sortOrder':'78','description':'10.1371/journal.ppat.1010342.g002 Fig 2 Immune cell infiltration is impaired in BEX1 KO hearts during CVB3 infection. A) Hematoxylin and Eosin staining was conducted in WT and BEX1 KO mice following the indicated treatments. Scale bar \u003d 125mum. B) The gating of CD45+ cells in representative WT and BEX1 KO 7 days post-infection hearts is shown for total leukocyte abundance using flow cytometry. D-K) Total Leukocytes (C), T lymphocytes (D), total monocytes (E), natural killers (F), B lymphocytes (G), myeloid-derived cells (H), neutrophils (I), infiltrating monocytes (J), and macrophages (K) were evaluated in WT and BEX1 KO hearts at the indicated post-infection time points using flow cytometry. d \u003d days. Statistical analyses by 2-way ANOVA. (* p\u003c0.05 CVB3-treated WT vs. uninfected WT; \u0026 p\u003c0.05 CVB3-treated BEX1 KO vs. uninfected BEX1 KO; # p\u003c0.05 BEX1 KO vs. WT same treatment).','shortDescription':'10.1371/journal.ppat.1010342.g002 Fig 2 Immune cell infiltration is impaired in BEX1 KO hearts during CVB3 infection. A) Hematoxylin and Eosin staining was conducted in WT and BEX1 KO mice following the indicated treatments. Scale bar \u003d 125mum. B) The gating of CD45+ cells in representative WT and BEX1 KO 7 days post-infection hearts is shown for total leukocyte abundance using flow cytometry. D-K) Total Le... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PLoS pathogens','journalText':'PLoS pathogens 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24777_ppat.1010342.g002.jpg','benchSciPubmedId':'35192678'},{'sku':'14-0451-82','imageId':'1020275','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19229_LSA-2021-01315_FigS1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19229_LSA-2021-01315_FigS1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19229_LSA-2021-01315_FigS1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19229_LSA-2021-01315_FigS1.jpg?time\u003d20240507','sortOrder':'79','description':'Figure S1. TNF inhibits M2 gene expression (related to Fig 1 ). (A) Gating strategy of wild-type BMDMs stained for Arg1, RELMalpha, and CD301. (B) Representative blots of wild-type BMDMs stimulated with IL4/IL13 or IL4/IL13 + TNF and percentages of RELMalpha + and CD301 + macrophages were determined by flow cytometry analysis. (C) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, or left untreated and percentages of CD301 + of F4/80 + macrophages were determined by flow cytometry analysis. (D) Representative blots for Fig 1D . (E) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, and/or Etanercept and percentages of Arg1 + of F4/80 + macrophages were determined by flow cytometry analysis. Data represent three independent experiments. (F) Gating strategy for the sorting of wound macrophages. Representative flow cytometry analysis of single cell suspensions isolated from Balb/c wild-type wound tissue at 14 dpi. 7-AAD - single cells were gated and analyzed for expression of CD45 and CD11b. 7-AAD - CD45 + CD11b + cells were gated and analyzed for expression of CD11b and F4/80. 7-AAD - CD45 + CD11b + F4/80 + cells were sorted by flow cytometry. (G) Gating strategy of small peritoneal macrophages from solvent or Etanercept-treated mice stained for Arg1 and RELMalpha. All values are means +- SEM; * P \u003c 0.05; **** P \u003c 0.0001. Statistically significant differences were determined by one-way ANOVA with Tukey correction. If not indicated otherwise superscripts','shortDescription':'Figure S1. TNF inhibits M2 gene expression (related to Fig 1 ). (A) Gating strategy of wild-type BMDMs stained for Arg1, RELMalpha, and CD301. (B) Representative blots of wild-type BMDMs stimulated with IL4/IL13 or IL4/IL13 + TNF and percentages of RELMalpha + and CD301 + macrophages were determined by flow cytometry analysis. (C) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, or left untrea... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Life science alliance','journalText':'Life science alliance 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19229_LSA-2021-01315_FigS1.jpg','benchSciPubmedId':'35027468'},{'sku':'14-0451-82','imageId':'933484','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time\u003d20240507','sortOrder':'80','description':'Fig. 11 The mechanism of distant antitumor effect analysis. The flow cytometry images of DCs (CD80 + CD86 + ) mature ( A ) and quantitative analysis ( B ); flow cytometry ( C ) and quantitative analysis ( D , E ) of activated CD3 + CD4 + CD8 + T cells after each treatment; the population of CD4 + Foxp3 + Tregs in the spleen according to flow cytometry ( F ) and the ratio of CD3 + CD8 + cytotoxic T cells versus CD3 + CD4 + Foxp3 + Tregs ( G ); flow cytometry analysis of CD45 + , F4/80 + ( H ) and quantitative analysis ( I , J ) in the distant tumor','shortDescription':'Fig. 11 The mechanism of distant antitumor effect analysis. The flow cytometry images of DCs (CD80 + CD86 + ) mature ( A ) and quantitative analysis ( B ); flow cytometry ( C ) and quantitative analysis ( D , E ) of activated CD3 + CD4 + CD8 + T cells after each treatment; the population of CD4 + Foxp3 + Tregs in the spleen according to flow cytometry ( F ) and the ratio of CD3 + CD8 + cytotoxic T cells ver... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 19, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of nanobiotechnology','journalText':'Journal of nanobiotechnology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19144_12951_2021_1162_Fig11_HTML.jpg','benchSciPubmedId':'34923976'},{'sku':'14-0451-82','imageId':'933463','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19102_elife-73215-fig3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19102_elife-73215-fig3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19102_elife-73215-fig3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19102_elife-73215-fig3.jpg?time\u003d20240507','sortOrder':'81','description':'Figure 3. Myofiber-specific ablation of IRE1alpha reduces abundance of satellite cells in injured muscle. ( A ) Representative photomicrographs of uninjured and 5d-injured TA muscle sections of Ern1 fl/fl and Ern1 cKO mice after immunostaining for Pax7 (red) and laminin (green) protein. Nuclei were identified by staining with DAPI. Scale bar: 50 um. White arrows point to Pax7 + satellite cells. ( B ) Average number of Pax7 + cells per field (~0.15 mm 2 ) in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. n \u003d 6 mice per group. ( C ) Relative mRNA levels of Pax7 in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice assayed by performing qPCR (n \u003d 3-5 mice in each group). ( D ) Representative immunoblots showing levels of Pax7 and unrelated protein GAPDH in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. ( E ) Primary mononuclear cells were isolated from TA muscle of Ern1 fl/fl and Ern1 cKO mice and subjected to FACS analysis for satellite cells. Representative FACS dot plots demonstrating the percentage of alpha7-integrin + cells in 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. ( F ) Quantification of alpha7-integrin + satellite cells in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice assayed by FACS (n \u003d 4 or 5 mice in each group). Data are expressed as mean +- SEM and analyzed by one-way analysis of variance (ANOVA) followed by Tukey\u0027s multiple comparison test. * p \u003c\u003d 0.05, values significantly','shortDescription':'Figure 3. Myofiber-specific ablation of IRE1alpha reduces abundance of satellite cells in injured muscle. ( A ) Representative photomicrographs of uninjured and 5d-injured TA muscle sections of Ern1 fl/fl and Ern1 cKO mice after immunostaining for Pax7 (red) and laminin (green) protein. Nuclei were identified by staining with DAPI. Scale bar: 50 um. White arrows point to Pax7 + satellite cells. ( B ) Averag... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 23, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19102_elife-73215-fig3.jpg','benchSciPubmedId':'34812145'},{'sku':'14-0451-82','imageId':'933441','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15194_fimmu-12-763067-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15194_fimmu-12-763067-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15194_fimmu-12-763067-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15194_fimmu-12-763067-g001.jpg?time\u003d20240507','sortOrder':'82','description':'Figure 1 FCM analysis of dynamic changes of M1-like and M2-like uterine macrophages during the peri-implantation period in mice. (A) Gating strategy used to identify uterine M1-like macrophages (CD45 + F4/80 + CD206 - ) and M2-like macrophages (CD45 + F4/80 + CD206 + ) in pregnant mice. FSC vs SSC gating was used to clean up the debris and dead cells. CD45 + represents leukocyte; F4/80 + represents macrophages; CD206 - and CD206 + represent M1-like and M2-like uterine macrophages, respectively. (B) Dynamic changes of M1-like macrophages, M2-like macrophages and Mphi during peri-implantation period in mice (n\u003e\u003d3). Error bars represent means +- SEM; two-tailed unpaired t-test, ns, not significant, *P \u003c 0.05 or ***P \u003c 0.001.','shortDescription':'Figure 1 FCM analysis of dynamic changes of M1-like and M2-like uterine macrophages during the peri-implantation period in mice. (A) Gating strategy used to identify uterine M1-like macrophages (CD45 + F4/80 + CD206 - ) and M2-like macrophages (CD45 + F4/80 + CD206 + ) in pregnant mice. FSC vs SSC gating was used to clean up the debris and dead cells. CD45 + represents leukocyte; F4/80 + represents macropha... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 10, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15194_fimmu-12-763067-g001.jpg','benchSciPubmedId':'34712245'},{'sku':'14-0451-82','imageId':'933422','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15193_gr4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15193_gr4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15193_gr4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15193_gr4.jpg?time\u003d20240507','sortOrder':'84','description':'Figure 4 Cardiac-derived TGF-beta1 alters gene expression programs and inflammation in white adipose tissue. ( A ) Heat map generated using differentially expressed genes from RNA sequencing of perigonadal white adipose tissue (pgWAT) from WT and TGF mice under control and high-fat diet. ( B ) Gene ontology analysis comparing RNA sequencing of TGF and WT pgWAT under control and high-fat diet. ( C ) Body mass of WT and TGF mice following 2 weeks of control or high-fat diet. ( D ) Flow cytometry for CD45-positive cells (CD45+) in pgWAT from the indicated genotypes following 2 weeks of control or high-fat diet. ( E ) qPCR for CD74 normalized to Ppia housekeeping gene from pgWAT from the indicated genotypes following 2 weeks of control or high-fat diet. Statistics were calculated using a two-way ANOVA, where * indicates p \u003c 0.05. Data are presented as the mean +- SEM. Group sizes are listed in the order of CD WT, CD TGF, HFD WT, and HFD TGF: (A, B) n \u003d 3, 3; (C) n \u003d 11, 13, 20, 15; (D) n \u003d 4, 4, 4, 4; and (E) n \u003d 12, 10, 11, 10. Figure 4','shortDescription':'Figure 4 Cardiac-derived TGF-beta1 alters gene expression programs and inflammation in white adipose tissue. ( A ) Heat map generated using differentially expressed genes from RNA sequencing of perigonadal white adipose tissue (pgWAT) from WT and TGF mice under control and high-fat diet. ( B ) Gene ontology analysis comparing RNA sequencing of TGF and WT pgWAT under control and high-fat diet. ( C ) Body mas... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular metabolism','journalText':'Molecular metabolism 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15193_gr4.jpg','benchSciPubmedId':'34583010'},{'sku':'14-0451-82','imageId':'933396','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'85','description':'Fig. 2 PTENalpha promotes tumor immune escape. a - g Cancer vaccination model of Mock or PTENalpha transfected Pten -/- B16 cells. a Schematic diagram of the cancer vaccine model. b Tumor volumes of C57BL/6 mice subjected to the cancer vaccination model were monitored overtime. The unimmunized group refers to mice without irradiated B16 cells immunization. The statistical significances between the immunized groups were indicated (PTENalpha-unimmunized, n \u003d 4 mice; other groups, n \u003d 5 mice, mean +- s.e.m., * P (d16) \u003d 0.0254, * P (d20) \u003d 0.0339, * P (d22) \u003d 0.0487, * P (d24) \u003d 0.0450, ** P \u003d 0.0077). c The tumor-infiltrating lymphocytes (TILs) were isolated when the tumor volumes of the Mock-immunized group reach 200 mm 3 , and the cells were subjected to flow cytometry analysis. The cell counts of CD45 + cells were used for statistical analysis ( n \u003d 4 mice, mean +- SD, ** P \u003d 0.0044). Gating strategies were shown in Supplementary Fig. 3b . d - g TILs were isolated when the tumor volumes of Mock-immunized group reach 200 mm 3 , and CD45 + cells were sorted, using for 10x scRNA-seq with two replicates. 25,098 cells were identified as 12 clusters utilizing graph-based clustering. d Cd8T cells were further analyzed and identified as 4 clusters utilizing graph-based clustering. e Violin plot of differentiated genes in the 4 clusters of Cd8T cells. The color of each violin is the average expression value of a given gene. f and g Umap and proportion of the 4 clusters of Cd8T cells','shortDescription':'Fig. 2 PTENalpha promotes tumor immune escape. a - g Cancer vaccination model of Mock or PTENalpha transfected Pten -/- B16 cells. a Schematic diagram of the cancer vaccine model. b Tumor volumes of C57BL/6 mice subjected to the cancer vaccination model were monitored overtime. The unimmunized group refers to mice without irradiated B16 cells immunization. The statistical significances between the immunized... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 26, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15190_41467_2021_25417_Fig2_HTML.jpg','benchSciPubmedId':'34446716'},{'sku':'14-0451-82','imageId':'933358','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15181_ACEL-20-e13412-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g006.jpg?time\u003d20240507','sortOrder':'86','description':'FIGURE 4 Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 week ( right ) at 30 dpi. (b) Quantification of number of CD11b neg CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b neg -gated cells analyzed by CD8 vs CD45 staining. (d) Quantification of number of CD8 + CD45 + cells in each group. (e) Representative flow cytometry plots of CD8 + -gated cells analyzed by CD8 vs NS4B (WNV-specific tetramer) staining. (f, g) Quantification of (f) number and (g) percent of NS4B + of CD8 + cells in each group. (h) Representative flow cytometry plots of NS4B + -gated cells analyzed by IFNgamma vs NS4B staining. (i, j) Quantification of (i) number and (j) normalized MFI of IFNgamma + of NS4B + CD8 + cells. MFI was normalized within each experiment to the average IFNgamma MFI of NS4B + CD8 + cells isolated from 16 week mice at 30 dpi. Each mouse is represented by a symbol and lines indicate mean +- SD. These data are the representative of three independent experiments with a total of 9-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons','shortDescription':'FIGURE 4 Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 wee... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15181_ACEL-20-e13412-g006.jpg','benchSciPubmedId':'34327802'},{'sku':'14-0451-82','imageId':'932267','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time\u003d20240507','sortOrder':'87','description':'4 FIGURE Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 week ( right ) at 30 dpi. (b) Quantification of number of CD11b neg CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b neg -gated cells analyzed by CD8 vs CD45 staining. (d) Quantification of number of CD8 + CD45 + cells in each group. (e) Representative flow cytometry plots of CD8 + -gated cells analyzed by CD8 vs NS4B (WNV-specific tetramer) staining. (f, g) Quantification of (f) number and (g) percent of NS4B + of CD8 + cells in each group. (h) Representative flow cytometry plots of NS4B + -gated cells analyzed by IFNgamma vs NS4B staining. (i, j) Quantification of (i) number and (j) normalized MFI of IFNgamma + of NS4B + CD8 + cells. MFI was normalized within each experiment to the average IFNgamma MFI of NS4B + CD8 + cells isolated from 16 week mice at 30 dpi. Each mouse is represented by a symbol and lines indicate mean +- SD. These data are the representative of three independent experiments with a total of 9-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons','shortDescription':'4 FIGURE Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 wee... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg','benchSciPubmedId':'34327802'},{'sku':'14-0451-82','imageId':'932248','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time\u003d20240507','sortOrder':'88','description':'3 FIGURE Uninfected aged mice exhibit myeloid cells that lack typical microglial markers. Adult (16 week) and aged (85 week) mice were infected with 100 PFU WNV-NY via footpad inoculation. At 9 dpi, a time point just prior to when mice begin succumbing to viral infection, leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of percent of CD11b + CD45 + cells in 16 week mock, 85 week mock, 16 week infected, and 85 week infected cortex. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression. (d) Quantification of percent CD45 hi , P2RY12 + CD45 lo , and P2RY12 neg CD45 lo cells in each group. (e) Representative flow cytometry plots of P2RY12 + CD45 lo -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of percent MHCII + of P2RY12 + CD45 lo -gated cells in each group. (g) Representative flow cytometry plots of P2RY12 neg CD45 lo -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of percent MHCII + of P2RY12 neg CD45 lo -gated cells in each group. These data are representative of two experiments with 6-10 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. (i) Representative images of 16 week ( top row ) and 85 week ( bottom row ) cortical tissue sections collected fr','shortDescription':'3 FIGURE Uninfected aged mice exhibit myeloid cells that lack typical microglial markers. Adult (16 week) and aged (85 week) mice were infected with 100 PFU WNV-NY via footpad inoculation. At 9 dpi, a time point just prior to when mice begin succumbing to viral infection, leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg','benchSciPubmedId':'34327802'},{'sku':'14-0451-82','imageId':'933377','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15181_ACEL-20-e13412-g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g007.jpg?time\u003d20240507','sortOrder':'89','description':'FIGURE 5 Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of number of CD11b + CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 + cells. (d) Quantification of number of P2RY12 + CD11b + cells in each group. (e) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs CD68 expression. (f) Quantification of number of CD68 + P2RY12 + cells in each group. (g) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of number of MHCII + P2RY12 + cells in each group. These data are the representative of two independent experiments with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. Exact p values noted; * p \u003c 0.05; ** p \u003c 0.01','shortDescription':'FIGURE 5 Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b)... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15181_ACEL-20-e13412-g007.jpg','benchSciPubmedId':'34327802'},{'sku':'14-0451-82','imageId':'932286','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time\u003d20240507','sortOrder':'90','description':'5 FIGURE Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of number of CD11b + CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 + cells. (d) Quantification of number of P2RY12 + CD11b + cells in each group. (e) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs CD68 expression. (f) Quantification of number of CD68 + P2RY12 + cells in each group. (g) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of number of MHCII + P2RY12 + cells in each group. These data are the representative of two independent experiments with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. Exact p values noted; * p \u003c 0.05; ** p \u003c 0.01','shortDescription':'5 FIGURE Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b)... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg','benchSciPubmedId':'34327802'},{'sku':'14-0451-82','imageId':'933339','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15181_ACEL-20-e13412-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g004.jpg?time\u003d20240507','sortOrder':'91','description':'FIGURE 6 Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 neg cells. (b) Quantification of number of P2RY12 neg CD11b + cells in each group. (c) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs CD68 expression. (d) Quantification of number of CD68 + P2RY12 neg cells in each group. (e) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of number of MHCII + P2RY12 neg cells in each group. These data are the representative of two experiment with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. Exact p values noted; * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001; **** p \u003c 0.0001','shortDescription':'FIGURE 6 Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expres... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15181_ACEL-20-e13412-g004.jpg','benchSciPubmedId':'34327802'},{'sku':'14-0451-82','imageId':'932305','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time\u003d20240507','sortOrder':'92','description':'6 FIGURE Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 neg cells. (b) Quantification of number of P2RY12 neg CD11b + cells in each group. (c) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs CD68 expression. (d) Quantification of number of CD68 + P2RY12 neg cells in each group. (e) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of number of MHCII + P2RY12 neg cells in each group. These data are the representative of two experiment with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. Exact p values noted; * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001; **** p \u003c 0.0001','shortDescription':'6 FIGURE Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expres... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg','benchSciPubmedId':'34327802'},{'sku':'14-0451-82','imageId':'933319','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15180_elife-66063-fig1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15180_elife-66063-fig1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15180_elife-66063-fig1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15180_elife-66063-fig1.jpg?time\u003d20240507','sortOrder':'93','description':'Figure 1. Two cell populations with skeletal stem cell characteristics in postnatal long bones. ( A ) Diagram showing two previously described skeletal stem cell (SSC) populations and the downstream populations they generate, which were defined by the specific expression patterns of cell surface proteins. Top: SSC lineage tree of the osteochondral SSC (ocSSC) that gives rise to bone, cartilage, and stromal populations. Bottom: the lineage tree of the perivascular SSC (pvSSC) able to give rise to bone, cartilage, adipose tissue, and stromal populations. BCSP: bone cartilage stroma progenitor; CP: cartilage progenitor; APC: adipogenic progenitor cell; Pre-Ad. : pre-adipocyte; OPC: osteochondrogenic progenitor cell. ( B ) Representative flow cytometric gating strategy for the isolation of ocSSCs (top) and pvSSCs (bottom). ( C ) Representative confocal microscopy images of in vivo derived single-color clonal colonies of renal capsule-transplanted purified ocSSCs (left) and pvSSCs (right) derived from Actin-CreERt Rainbow mice. Three independent transplants per cell type under renal capsules were performed. ( D ) Renal capsule transplant-derived ossicles of purified GFP-labeled ocSSCs (top) and pvSSCs (bottom). Images show the photograph of the kidney with transplant (top left) and GFP signal of graft tissue (bottom left) as well as Movat pentachrome cross-section staining (right). ( E ) Quantification of ocSSC (top) and pvSSC (bottom) graft composition. Results of three separate','shortDescription':'Figure 1. Two cell populations with skeletal stem cell characteristics in postnatal long bones. ( A ) Diagram showing two previously described skeletal stem cell (SSC) populations and the downstream populations they generate, which were defined by the specific expression patterns of cell surface proteins. Top: SSC lineage tree of the osteochondral SSC (ocSSC) that gives rise to bone, cartilage, and stromal ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 19, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15180_elife-66063-fig1.jpg','benchSciPubmedId':'34280086'},{'sku':'14-0451-82','imageId':'933301','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'94','description':'Fig. 1 Cell characteristics of bone marrow derived macrophages (BMDMs) and mesenchymal stem cells (MSCs). Phase contrast microscopic image of BMDMs 5 days after in vitro culture ( A ). Flow cytometric analysis of BMDMs for F4/80 ( B ). Flow cytometric analysis of MSCs for CD90, CD105, CD34, and CD45 ( C ). CXCL12 gene knockout in MSCs. Transfection of MSCs with a GFP-positive CRISPR/Cas9 plasmid to knock out CXCL12 gene ( D ). Western blotting for knockout efficiency ( E ). beta-actin was used as a control. CXCL12 measurement in the serum-free conditioned media of MSC CXCL12+/+ and MSC CXCL12-/- by ELISA ( F ). Each point indicates an experiment (horizontal lines: mean)','shortDescription':'Fig. 1 Cell characteristics of bone marrow derived macrophages (BMDMs) and mesenchymal stem cells (MSCs). Phase contrast microscopic image of BMDMs 5 days after in vitro culture ( A ). Flow cytometric analysis of BMDMs for F4/80 ( B ). Flow cytometric analysis of MSCs for CD90, CD105, CD34, and CD45 ( C ). CXCL12 gene knockout in MSCs. Transfection of MSCs with a GFP-positive CRISPR/Cas9 plasmid to knock ou... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 26, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cellular \u0026 molecular biology letters','journalText':'Cellular \u0026 molecular biology letters 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15178_11658_2021_273_Fig1_HTML.jpg','benchSciPubmedId':'34174813'},{'sku':'14-0451-82','imageId':'933282','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'95','description':'Fig. 3 Flow cytometry analyses of the hypothalamus ( A , B , E ), visceral fat pad ( C , F ), and peritoneal cavity (PEC, D , G ) demonstrated macrophage migration following HFD. E An example of flow cytometry gating, indicating the presence of the CD45 high macrophage population that can be distinguished from the CD45 low microglia specifically in the hypothalami of HFD male mice, but not in female mice. These populations were quantified and presented as the % of all live cells in A (macrophages, CD11b+CD45 high ) and B (microglia, CD11b+Cd45 low ). C Quantification of F4/80+CD11b+ macrophages in the stromal vascular fraction of visceral adipose tissue following Ctr and HFD in males (left) and females (right). F An example of the flow cytometry gating strategy from visceral fat. D , G Peritoneal cavity (PEC) cells were analyzed by flow cytometry (gating example G ) and the percent of F4/80+CD11b+ macrophages of all live cells are presented graphically in D , males on the left and females on the right. n\u003d9-12 total, 3 repeats consisting of 3-4 mice per group. Statistical significance (*) between Ctr (gray bars) and HFD (black bars) were determined by Student\u0027s T test followed by Tukey\u0027s post hoc test','shortDescription':'Fig. 3 Flow cytometry analyses of the hypothalamus ( A , B , E ), visceral fat pad ( C , F ), and peritoneal cavity (PEC, D , G ) demonstrated macrophage migration following HFD. E An example of flow cytometry gating, indicating the presence of the CD45 high macrophage population that can be distinguished from the CD45 low microglia specifically in the hypothalami of HFD male mice, but not in female mice. T... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 21, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15177_12974_2021_2183_Fig3_HTML.jpg','benchSciPubmedId':'34154608'},{'sku':'14-0451-82','imageId':'933244','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'96','description':'Figure 2 The resident microglial population increases in proportion and total number in the ipsilateral thalamus at PSD 14. At PSD 14, brains were harvested for cell cytometry. Single cell suspensions were obtained from cortex and thalamus. Cells were stained with CD45 antibody and CD11b antibody to measure the number and percentage of microglia in thalamus . ( A ) Representative cell cytometry plots generated from ipsilateral cortex and thalamus from sham and PSD 14 brains. The percentage of microglia, peripheral myeloid cells (pMyeloids), and lymphocytes is indicated numerically on the plots. ( B ) Illustration showing location of cortex and thalamus harvest sites from brain sections corresponding to + 1 or - 2 mm from bregma. ( C ) Number of CD45 Int /CD11b + cells in cortex and thalamus for sham and PSD 14 brains. * P \u003c 0.05, unpaired t test.','shortDescription':'Figure 2 The resident microglial population increases in proportion and total number in the ipsilateral thalamus at PSD 14. At PSD 14, brains were harvested for cell cytometry. Single cell suspensions were obtained from cortex and thalamus. Cells were stained with CD45 antibody and CD11b antibody to measure the number and percentage of microglia in thalamus . ( A ) Representative cell cytometry plots genera... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 15, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15176_41598_2021_91998_Fig2_HTML.jpg','benchSciPubmedId':'34131204'},{'sku':'14-0451-82','imageId':'932342','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time\u003d20240507','sortOrder':'97','description':'1 Figure Adipoq Cre targets BM adipose lineage cells FACS analysis of tdTomato + cells in the bone marrow cells (percentages represent average values). Immunofluorescence staining of aggrecan and DAPI of femur sections from Adipoq Cre ; R26 tdTomato mice. Scale bar \u003d 200/100/50 um in left/ upper right/ bottom right images. CB: cortical bone, TB: trabecular bone. Immunofluorescence staining of RANKL and Hoechst in bone marrow cells from Adipoq Cre ; R26 tdTomato mice. Scale bar \u003d 50 um. qPCR results of Rankl in BMAT and peripheral adipose tissues, including epididymal (eWAT), inguinal (iWAT), and interscapular (iBAT) ( n \u003d 3 independent biological replicates). Data were compared using one-way ANOVA (** indicates P \u003c 0.01), and error bars are standard deviations. Immunofluorescence staining of RANKL during in vitro adipogenesis of BMSCs from Adipoq Cre ; rankl fl/fl mice ( Rankl -/- ) and rankl fl/fl mice ( Rankl +/+ ). Scale bar \u003d 50 mum. Western blotting analyses of RANKL in BMSCs during in vitro BMSCs adipogenesis ( n \u003d 3 independent biological replicates). Data were compared using an unpaired t -test (** indicates P \u003c 0.01), and error bars are standard deviations.','shortDescription':'1 Figure Adipoq Cre targets BM adipose lineage cells FACS analysis of tdTomato + cells in the bone marrow cells (percentages represent average values). Immunofluorescence staining of aggrecan and DAPI of femur sections from Adipoq Cre ; R26 tdTomato mice. Scale bar \u003d 200/100/50 um in left/ upper right/ bottom right images. CB: cortical bone, TB: trabecular bone. Immunofluorescence staining of RANKL and Hoec... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 5, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'EMBO reports','journalText':'EMBO reports 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg','benchSciPubmedId':'34121311'},{'sku':'14-0451-82','imageId':'933206','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'98','description':'Fig. 1 Genetic ablation of IL-6 reverses GBM immunosuppression. GBM was induced by RCAS-mediated genetic engineering in Ntv-a ; Ink4a-Arf -/- ; Pten fl/fl ; LSL-Luc donor mice, followed by orthotopic tumor implantation into Cdh5-Cre ERT2 ; Il6 fl/fl recipient mice that were pretreated with (IL-6-DeltaEC) or without (Control) tamoxifen. Two weeks after tumor implantation, tumors were excised. a Schematic approach. b , c Tumor-derived single-cell suspensions were analyzed by CyTOF. b Representative CyTOF sorting. c Quantitative results (mean +- SEM, n \u003d 4 mice). Statistical analysis by two-tailed Student\u0027s t -test. d - f Tumor-derived single-cell suspensions were analyzed by flow cytometry. d Analysis for CD3 + T cells. Left, representative cell sortings. Right, quantified results ( n \u003d 6 mice, mean +- SEM). Statistical analysis by two-tailed Student\u0027s t -test. e , f Analysis for e CD4 + /CD8 + T cells or f myeloid cells ( n \u003d 6 mice, mean +- SEM). Statistical analysis by two-tailed Student\u0027s t -test. g , h Tissue lysates from normal brains and tumors were subjected to ELISA analysis for g IL-10 and h TGF-beta expression (mean +- SEM, n \u003d 4 mice for IL-6-DeltaEC GBM group and n \u003d 3 mice for other groups). Statistical analysis by two-way ANOVA with Sidak\u0027s test. Source data are provided as a Source data file.','shortDescription':'Fig. 1 Genetic ablation of IL-6 reverses GBM immunosuppression. GBM was induced by RCAS-mediated genetic engineering in Ntv-a ; Ink4a-Arf -/- ; Pten fl/fl ; LSL-Luc donor mice, followed by orthotopic tumor implantation into Cdh5-Cre ERT2 ; Il6 fl/fl recipient mice that were pretreated with (IL-6-DeltaEC) or without (Control) tamoxifen. Two weeks after tumor implantation, tumors were excised. a Schematic app... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 8, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14979_41467_2021_23832_Fig1_HTML.jpg','benchSciPubmedId':'34103524'},{'sku':'14-0451-82','imageId':'933225','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'99','description':'Fig. 2 IL-6 neutralization enhances T-cell infiltration into GBM tumors and improves animal survival but does not sensitize tumor to immune checkpoint blockade. GBM was induced in WT B6 mice, followed by injection with control IgG, anti-IL-6 antibody (Ab), immune checkpoint inhibitors (ICIs), or ICIs plus anti-IL-6 Ab. a Schematic approach. b , c Survival and tumor growth analyses ( n \u003d 8-12 mice, specific n numbers are shown in the figure). b Mouse survival was monitored for 60 days and subjected to two-sided log-rank Mantel-Cox analysis. MS, median survival. c Tumor volume was analyzed by bioluminescence imaging during days 13-23 (mean +- SEM). Statistical analysis by two-way ANOVA with Dunnett\u0027s test. d - g Tumors were excised 2 days after treatment. Tumor-derived single-cell suspensions were stained with antibodies against CD45, d CD3, e CD11b, f CD4, CD8, CD3, and g Ki67, IFN-gamma, and CD69, followed by flow cytometry analyses. d Analysis for CD3 + T cells. Left, representative cell sortings. Right, quantified results ( n \u003d 6 mice, mean +- SEM). Statistical analysis by one-way ANOVA with Fisher\u0027s LSD test. e - g Quantified results for immune cells ( n \u003d 6 mice, mean +- SEM). Statistical analysis by one-way ANOVA with Fisher\u0027s LSD test. Source data are provided as a Source data file.','shortDescription':'Fig. 2 IL-6 neutralization enhances T-cell infiltration into GBM tumors and improves animal survival but does not sensitize tumor to immune checkpoint blockade. GBM was induced in WT B6 mice, followed by injection with control IgG, anti-IL-6 antibody (Ab), immune checkpoint inhibitors (ICIs), or ICIs plus anti-IL-6 Ab. a Schematic approach. b , c Survival and tumor growth analyses ( n \u003d 8-12 mice, specific ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (14-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 8, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14979_41467_2021_23832_Fig2_HTML.jpg','benchSciPubmedId':'34103524'}],'Advanced Verification':[{'sku':'14-0451-82','imageId':'757661','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8108_cancers-10-00403-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8108_cancers-10-00403-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8108_cancers-10-00403-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8108_cancers-10-00403-g004.jpg?time\u003d20240507','sortOrder':'2','description':'Figure 4 Regulation of CD45 + cell number by both MEK and Hh signaling pathways. ( A ) Representative immunofluorescent staining images of CD45 + cells in liver tissues after drug treatments. ( B ) Summary of A from 10 images in each group (from at least 3 mice) with the number of CD45 + cells per field under microscope (200x). ( C ) Summary of flow cytometry analysis of CD45+ cells in different treatment groups (from three mice/group). * indicates p \u003c 0.05 and ** indicates a more than additive effect via BLISS independence analysis. {TM}','shortDescription':'Figure 4 Regulation of CD45 + cell number by both MEK and Hh signaling pathways. ( A ) Representative immunofluorescent staining images of CD45 + cells in liver tissues after drug treatments. ( B ) Summary of A from 10 images in each group (from at least 3 mice) with the number of CD45 + cells per field under microscope (200x). ( C ) Summary of flow cytometry analysis of CD45+ cells in different treatment g... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody','title':'CD45 Antibody (14-0451-82)','appAbv':'TM','appName':'Cell treatment','type':'Advanced Verification','journalText':'','sourceType':'7','benchsci':true,'imageName':'tfs_8108_cancers-10-00403-g004.jpg','benchSciPubmedId':'0'}]}" image-displayed-id="'90427'" product-sub-type="'antibody_primary'" prod-type="'antibody'" page-type="PDP" product-id="'14-0451-82'"> <div class="tabs"> <ul class="nav nav-pills"> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Antibody Testing Data"> <a class="tab-text"> Antibody Testing Data (1) </a> </li> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Published Figures"> <a class="tab-text"> Published Figures (95) </a> </li> <li class="tab" 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<div class = "verification-certificate hide" > <span class="icon-certification"></span> <span class="adv-cert-text">{{ $ctrl.currentElement.advancedVerification.fullName }}</span> <div class="cert-provider">{{ $ctrl.currentElement.advancedVerification.text }}</div> </div> <h2 class="product-name" ng-show="!$ctrl.isVideo"> CD45 Antibody (14-0451-82) in Flow </h2> <div ng-show="!$ctrl.isVideo"> <div class="image-desc"> <div class="product-desc-text viewing-more-long-description"> <span class="image-journal-text" > </span> <span class="short-desc"> Staining of C57Bl/6 splenocytes with 0.25 µg of Rat IgG2b Isotype Control Purified (Product # 14-4031-82) (open histogram) or 0.25 µg of Anti-Mouse CD45 Purified (filled histogram) followed by Anti-Rat IgG FITC (Product # 11-4811-85). 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(IHC)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="876514" data-index="64"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14977_41467_2021_23197_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932874" data-index="65"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19139_biomedicines-09-00157-g005.jpg?time=20240507" alt="CD45 Antibody in Western Blot (WB)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1139447" data-index="66"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020389" data-index="67"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24743_fphar-13-1095757-g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020332" data-index="68"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24778_jci-132-160097-g179.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020370" data-index="69"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24779_jciinsight-7-159875-g201.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020351" data-index="70"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24779_jciinsight-7-159875-g200.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020256" data-index="71"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="952744" data-index="72"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_20586_jciinsight-7-154824-g203.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020313" data-index="73"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_21405_jci-132-157338-g101.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="952699" data-index="74"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020294" data-index="75"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24777_ppat.1010342.g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020275" data-index="76"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19229_LSA-2021-01315_FigS1.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933484" data-index="77"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933463" data-index="78"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19102_elife-73215-fig3.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933441" data-index="79"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15194_fimmu-12-763067-g001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933422" data-index="80"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15193_gr4.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933396" data-index="81"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933358" data-index="82"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g006.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932267" data-index="83"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932248" data-index="84"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933377" data-index="85"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g007.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932286" data-index="86"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933339" data-index="87"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g004.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932305" data-index="88"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933319" data-index="89"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15180_elife-66063-fig1.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933301" data-index="90"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933282" data-index="91"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933244" data-index="92"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932342" data-index="93"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933206" data-index="94"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933225" data-index="95"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="757661" data-index="96"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_8108_cancers-10-00403-g004.jpg?time=20240507" alt="CD45 Antibody"/> </div> </div> </div> </div> </div> <noscript> <div itemscope itemtype="http://schema.org/ImageGallery"> <h2>Product Image Gallery</h2> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/14-0451-82_CD45_Flow_1-20170119083539.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Staining of C57Bl/6 splenocytes with 0.25 µg of Rat IgG2b Isotype Control Purified (Product # 14-4031-82) (open histogram) or 0.25 µg of Anti-Mouse CD45 Purified (filled histogram) followed by Anti-Rat IgG FITC (Product # 11-4811-85). Cells in the lymphocyte gate were used for analysis.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24425_ijms-23-08238-g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Clonal assay of MSCs after co-culture with HSCs. ( A ) Representative flow cytometric profiles of MSCs (upper, CD31 - , CD45 - , Ter119 - , Sca-1 + , and PDGFR-alpha + cells) and HSCs (bottom, c-Kit + , Lin - , and Sca-1 + cells). Microscopic views of MSCs (upper) and HSCs (bottom). ( B , C ) Cell proliferation of MSCs ( B ) and HSCs ( C ) 2, 4, 6, and 8 days after co-culture ( n = 6). * p < 0.05 and ** p < 0.01 between direct and indirect co-culture. ( D ) MSC and HSC population in whole mesenchymal and hematopoietic cells. MSCs were sorted on day -1, and we waited until they attached to the bottom of the dish on day 0. After co-culture of MSCs and HSCs for 3, 5, and 7 days, cells were collected, sorted based on EGFP expression, and both cell types were detected using stem cell markers by flow cytometry. ( E ) Real-time PCR analysis of mesenchymal lineage marker expression in MSCs following a 3-week treatment with mesenchymal differentiation media after co-culture with HSCs ( n = 5). * p < 0.05 vs. MSCs (-HSCs).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_27589_mBio.01183-20-f0009.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">FIG 9 ZIKV-infected mouse brain displays local BBB impairment, leukocyte infiltration, and CAM upregulation. (a) RT-qPCR analyses of ZIKV genome in the brain of ZIKV-infected Ifnar -/- mice 7 dpi. (b) Picture of dissected brains from EB-injected mock- and ZIKV-infected mice at 7 dpi. (c) Quantification Evans blue fluorescence in brain slices from mock- and ZIKV-infected animals. Results are expressed means +- SEMs ( n = 3) and analyzed using a Wilcoxon-Mann-Whitney test. ****, P < 0.0001 compared to CT. (d) Three-micron consecutive paraffin sections were processed with Luxol blue and stained either with an anti-pan-flavivirus or an anti-CD45 (lymphoid cells) (brown labeling) antibody. Bars. 10 mum. (e) RT-qPCR analyses of inflammatory genes in ZIKV-infected brains. Results are expressed as means of the fold change ( n = 3) using GAPDH as a housekeeping gene (genes where the ratio gene/housekeeping gene is statistically significant [ P < 0.05] from CT) (see Fig. S8a ). (f) RT-qPCR analyses of CAMs in ZIKV-infected brains. Results are expressed as means of the fold change ( n = 3) using GAPDH as a housekeeping gene (genes where the ratio gene/housekeeping gene is statistically significant [ P < 0.05] from CT) (see Fig. S8a ). (g) RT-qPCR analyses of TJ and AJ genes in ZIKV-infected brains. Results are expressed as means of the fold change ( n = 3) using GAPDH as a housekeeping gene (genes where the ratio gene/housekeeping gene is statistically significant [ P < 0.05] from CT) (</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24775_EMS85829-f002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20587_ijms-23-04900-g001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry (ICC/IF)" title="CD45 Antibody (14-0451-82) in ICC/IF"> <figcaption itemprop="caption">Compromised self-renewal of ASCs cultured from trappc9-null mice. ASCs were isolated from WT and trappc9-deficient mice and cultured as in Methods. Both WT and KO ASCs at passage-3 were subjected to analyses. ( A ) Confocal images showed that ASCs isolated from WT and trappc9-null (KO) mice expressed mesenchymal stem cell markers and were devoid of hematopoietic CD45. Arrowheads point to cells containing two or more nuclei. Scale bars: 100 mum. ( B ) Comparison of the growth rate between WT and trappc9-deficient (KO) ASCs. ASCs were cultured at a density of 1 x 10 5 in T25 flasks and counted every 24 h for 6 days. Cell counting was performed with a hemocytometer. ( C ) Quantification of cells with two or more nuclei revealed that trappc9-null (KO) ASCs were defective in cell division. Images captured from 3 randomly chosen visual fields from cells for each genotype were used for cell counting. ( D ) Apoptosis of cells in WT and trappc9-deficient (KO) ASC cultures was examined by flow cytometry-based analysis of phosphatidylserine exposure (Annexin V-FITC staining) and plasma membrane integrity (propidium iodide staining). Shown are dot plot graphs from one of three individual analyses. Similar observations were achieved in other two experiments. Data in ( B , C ) are Mean +- SD. Each symbol represents one experiment. Statistical significance was determined by unpaired two-tailed Student's t -test: * p < 0.05; ** p < 0.01; *** p < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24776_41467_2021_23770_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry (ICC/IF)" title="CD45 Antibody (14-0451-82) in ICC/IF"> <figcaption itemprop="caption">Diurnal proliferation of adipocyte progenitor cells (APCs) in epididymal adipose tissue (eWAT). a Experimental model: adipose progenitor cells (APC) within the eWAT and iWAT stromal vascular cells were isolated at ZT0 and ZT12 from lean mice fed ad libitum control chow, for further gene expression and immunostaining analysis. b , c RT-PCR analysis reveals expression of progenitor (Dcn and CD34), endothelial (CD31), and lymphocyte (CD45) markers in eWAT/APC and eWAT/non-APC cells from lean mice isolated at ZT0 and ZT12 ( n = 5 animals for APC - and n = 10 animals for APC + /zeitgeber time, ZT). mRNA levels for lean mice at APC + /ZT0 were set to 1 for all genes. d Representative staining of KI67 (vs. DAPI) in eWAT-APC (scale bar = 50 um). Staining performed once from 3 biological replicates. e , f RT-PCR analysis reveals expression of circadian (left panel) and proliferation genes (right panel) in eWAT/APC ( e ) and eWAT / non-APC cells ( f ) from lean mice isolated at ZT0 and ZT12 ( n = 5 animals for APC - and n = 10 animals for APC + /ZT). mRNA levels for lean mice at APC + /ZT0 were set to 1 for all genes. g Experimental model: EdU was administered to lean mice fed ad libitum control chow at ZT0 and ZT12. eWAT and iWAT SVF were isolated from fat pads harvested 4 h following EdU injection and the subsequent adipose APC were isolated for further analysis. h Representative fluorescence activated cell sorting of EdU-positive cells in eWAT-APC isolated at ZT4 and ZT16, 4 h follo</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)" title="CD45 Antibody (14-0451-82) in ICC/IF, Flow"> <figcaption itemprop="caption">3 Fig CXCL12 is functionally important for maintaining stromal-hematopoietic coupling. ( A ) Conceptual diagram of CXCL12 conditional deletion experiment. Col2a1-cre ; Cxcl12 GFP/+ ; R26R tdTomato mice were mated with Cxcl12 fl/fl mice to generate Col2a1-cre ; Cxcl12 GFP/fl ; R26R tdTomato (Col2a1-CXCL12 cKO) and Cxcl12 GFP/fl ; R26R tdTomato (Control) mice. In Col2a1-CXCL12 cKO mice, Cxcl12-GFP + cells lose functional CXCL12 expression but still express GFP in a Cxcl12 promoter/enhancer-dependent manner. ( B ) CD45 staining of Control (left panels) and Col2a1-CXCL12 cKO (right panels) bone marrow. Dotted area = magnified view of Cxcl12 -GFP + reticular stromal cells and neighboring CD45 + hematopoietic cells. Green = Cxcl12-GFP; red = tdTomato; magenta = CD45-Alexa647; gray = DAPI. Scale bar = 10 mum. n = 4 mice per group. ( C ) Flow cytometry analysis of Control and Col2a1-CXCL12 cKO bone marrow cells. The percentage of CD45 + cells in total bone marrow cells (center) and CD45 + GFP + cells in whole GFP + fraction (right). n = 4 mice per group. Two-tailed, Mann-Whitney U test. All data are presented as mean +- SD.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14822_urn-x-wiley-15821838-media-jcmm16285-jcmm16285-fig-0001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry (ICC/IF)" title="CD45 Antibody (14-0451-82) in ICC/IF"> <figcaption itemprop="caption">1 FIGURE Expression of Cyp26a1 in mouse uterine tissue and uterine NK cells during the peri-implantation period. (A) qPCR to detect the expression of Cyp26a1 on gd4-gd7 uterine tissue. (B) Western blotting to detect the expression of Cyp26a1 on gd4-gd7 uterine tissue. (C) qPCR to detect the expression of Cyp26a1 in CD45 + CD3 - CD122 + NK cells isolated from the uterus and spleen on gd5. (D) qPCR to detect the expression of Cyp26a1 in CD45 + CD3 - CD122 + NK cells isolated from the uterus on gd4-gd7. (E) Representative graph of flow cytometric assays to detect CD45 + CD3 - CD122 + Cyp26a1 + NK cells in the uterus on gd4-gd7, the marker molecules were as follows: CD3-PE, CD45-PerCP-Cy5.5, CD122-APC and Cyp26a1-Alexa Fluor 488, The cells under gate CD45 + CD3 - shown in the figure. (F) Percentages of Cyp26a1 + NK cells in gated CD45 + CD3 - CD122 + NK and CD122 + NK cells in gated CD45 + CD3 - cells in the uterus on gd4-gd7. (G) Upper picture: immunofluorescence detection of Cyp26a1 expression in CD45 + CD3 - CD122 + NK cells isolated from the uterus on gd5 (63 x objective); lower picture: confocal photography of Cyp26a1 + NK cells and Cyp26a1 - NK cells isolated from the uterus on gd5 (20 x and 63 x objective). Data were means +- SEM from three biological replicates, *represents P < .05, **represents P < .01 (two-tailed unpaired Student's t test) (A and C). Data were representative of two (A, B and C) or three (E, F and G) independent experiments</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15168_dmm-13-044404-g2.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry (ICC/IF)" title="CD45 Antibody (14-0451-82) in ICC/IF"> <figcaption itemprop="caption">Fig. 2. Optimized sample preparation protocol for scRNA-seq captures major lung cell types of the epithelial, endothelial, immune and mesenchymal lineages. (A) Distribution of the 4 color-coded lineages quantified from published whole-lung scRNA-seq datasets (; ; preprint). (B) Confocal images of immunostained adult Rosa Sun1GFP/+ ; Shh Cre/+ lungs, in which epithelial cell nuclei are genetically marked by nuclear envelope-targeted GFP (), whereas ERG and CD45 (also known as PTPRC) mark endothelial and immune cells, respectively, and triple-negative nuclei (DAPI) are considered mesenchymal. We used the GFP reporter instead of NKX2-1 because both NKX2-1 and ERG are rabbit antibodies. Percentages are from 2 lungs with 3 images each containing thousands of cells. Scale bar: 10 mum. (C) An all-inclusive FACS gating strategy to separate all live cells (Sytox Blue negative) into the 4 lung cell lineages. (D) Skewed distributions of the 4 color-coded lung cell lineages from FACS are compensated by remixing them in equal proportions, adjusted for lineage-specific cell viability, for scRNA-seq. 3245 cells were sequenced. Distributions of the constituent cell types in each lineage can be obtained from scRNA-seq. airway cells, ciliated and club cells; AM, alveolar macrophages; A/VSM, airway/vascular smooth muscle cells; baso, basophils; DC, dendritic cells; IM, interstitial macrophages; mono, monocytes; neu, neutrophils; NK cells, natural killer cells.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4922_pone0206539g003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry (ICC/IF)" title="CD45 Antibody (14-0451-82) in ICC/IF"> <figcaption itemprop="caption">Fig 3 Immunohistological features of serially transplanted cervical cancer PDXs. Representative example of a PDX showing comparable histology (H&E) and immunoreactivity for diagnostic markers of cervical cancer in the primary biopsy and primary and secondary PDXs. Columns 2 and 3 show staining patterns for p16 INK4a (brown nuclear staining), HPV (brown nuclear and cytoplasmic immunostaining). Insets, isotype IgG control showing negative immunostaining. Scale bars 10 mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/CD45_27912060_IF_9_nihms874807f3_20180524.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry (ICC/IF)" title="CD45 Antibody (14-0451-82) in ICC/IF"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3200_jciinsight-1-87680-g001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry, Immunohistochemistry (Paraffin) (ICC/IF, IHC (P))" title="CD45 Antibody (14-0451-82) in ICC/IF, IHC (P)"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry and Immunohistochemistry (Paraffin)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12858_ncomms9835-f2.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)" title="CD45 Antibody (14-0451-82) in ICC/IF, Flow"> <figcaption itemprop="caption">Figure 2 Loss of Gata5 from renal endothelial cells leads to renal alterations. ( a ) GATA5 is expressed in the kidney as assessed by western blot performed on total kidney extracts. ( b ) Gata5 is essentially expressed in the glomeruli as assessed by qPCR on isolated glomeruli (Glo) and microdissected tubules (Tub) from Wt mice kidneys. ( n =3-5 per group). The results are reported as mean+-s.e.m. * P <0.05 versus Gata5 +/+ mice (Mann-Whitney test). ( c , d ) Specific deletion of Gata5 in endothelial cells (e Gata5-null mice) virtually abolished renal and glomerular expression of Gata5 ( n =3 per group). The results are reported as mean+-s.e.m. * P <0.05 versus eGata5 +/+ mice (Mann-Whitney test). ( e ) The expression of the glomerular genes Nphs1 (nephrin) and Nphs2 (podocin) as measured by qPCR ( n =6 per group) was increased in Gata5 -null mice. The results are reported as mean+-s.e.m. * P <0.05 versus Gata5 +/+ mice; *** P <0.005 versus Gata5 +/+ mice ( t -test for nephrin; Mann-Whitney test for podocin). ( f - i ) Absence of Gata5 induces glomerular lesions (sections are stained with periodic acid Schiff; scale bar, 30 mum; n =5 per group) and renal inflammation as assessed by leucocytes CD45 immunostaining (scale bar, 200 mum; n =4 per group). The results are reported as mean+-s.e.m. *** P <0.005 versus Gata5 +/+ mice (Mann-Whitney test). ( j - n ) Deletion of Gata5 from endothelial cells reproduces the renal phenotype of global Gata5 deletion: both Nephs1 and Nphs2 tr</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/pone0081030g005-20180918151446.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunocytochemistry (ICC/IF)" title="CD45 Antibody (14-0451-82) in ICC/IF"> <figcaption itemprop="caption">Figure 5 beta-catenin activation enhances hemangioblast formation. (A) (i) Scoring of the number of BL-CFC compared to the number of EB'sfor each condition by day 8 of differentiation shows activation of thecanonical Wnt pathway (DP-betaC or BIO) results in higher percentage ofBL-CFC compared to control cultures (Mean %, +/- SEM, n=3). (ii)Hemangioblasts/Early hematopoietic progenitors (CONDITION 2) wereanalysis for expression of mesodermal markers Flk1 and Brachyury by flowcytometry. (iii) RT-PCR analysis of key self-renewal and differentiationgenes. (B) Flow cytometry analysis was performed on thehemangioblast/early hematopoietic progenitors to determine thepercentage of cells expressing CD41, CD45, c-Kit, Sca1 and Flt3. Gatingon the CD41 + , CD45 + population revealed that theseearly hematopoietic progenitors also expressed the HSC markers Sca1 andc-Kit (Representative images shown, n=3). (C) (i) Total cell populationfrom CONDITION 2 were analyzed for key HSC markers Sca1 and c-Kit byflow cytometry. (ii) The early hematopoietic progenitor populations(Sca1 + c-Kit + cells) were sorted andImmunofluorescence performed to confirm higher levels of total andactive beta-catenin in DP-betaC -tet and E14 cells + BIO. (iii) RT-PCRanalysis of key hematopoietic genes within theSca-1 + c-kit + hematopoietic progenitor cellsand (iv) erythroid/globin genes. The control cells (DP-betaC + tet or E14ES cells -BIO) were used as calibrators and the fold change wascalculated using the 2 -</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8108_cancers-10-00403-g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))" title="CD45 Antibody (14-0451-82) in IHC (P)"> <figcaption itemprop="caption">Figure 4 Regulation of CD45 + cell number by both MEK and Hh signaling pathways. ( A ) Representative immunofluorescent staining images of CD45 + cells in liver tissues after drug treatments. ( B ) Summary of A from 10 images in each group (from at least 3 mice) with the number of CD45 + cells per field under microscope (200x). ( C ) Summary of flow cytometry analysis of CD45+ cells in different treatment groups (from three mice/group). * indicates p < 0.05 and ** indicates a more than additive effect via BLISS independence analysis.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/CD45_29098081_IF_9_JOPH2017-1639012002_20180524.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))" title="CD45 Antibody (14-0451-82) in IHC (P)"> <figcaption itemprop="caption">Figure 2 Characteristics histopathological findings of lacrimal gland in a mouse model of cGVHD. Hematoxylin & eosin (H&E) staining for lacrimal gland tissue sections from GVHD-affected mouse model (a, c) and syngeneic control (b, d). Immunostaining for CD45 + cells (in green and red arrow) and cell nuclei (stained with 4',6-diamidino-2-phenylindole (DAPI) in blue) in the lacrimal gland collected from the GVHD-impaired mice (e) and syngeneic controls (f). Transmission electron microscopic (TEM) findings of the lacrimal gland in a mouse model of cGVHD (g, i) and the syngeneic controls (h, j). (g, h) Yellow arrows, secretory vesicles. Scale bar = 50 mu m (a, b), 25 mu m (c, d), 50 mu m (e, f), 5 mu m (g, h), and 0.5 mu m (i, j). cGVHD mice, n = 10; syngeneic control mice, n = 10. Representative figures from three independent experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/14569882-27699223-Ki-67-jciinsight-1-87680-g005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))" title="CD45 Antibody (14-0451-82) in IHC (P)"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (Paraffin)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/14140282-27699223-CD140b-PDGFRB-jciinsight-1-87680-g003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))" title="CD45 Antibody (14-0451-82) in IHC (P)"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (Paraffin)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/14045182-26151762-CD45-elife07125fs004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))" title="CD45 Antibody (14-0451-82) in IHC (P)"> <figcaption itemprop="caption">Figure 3--figure supplement 1. Microenvironmental remodeling in Ptf1a cKO; Kras G12D pancreata. Pancreata were harvested 2 weeks following TM administration (0.17 mg/g) to mice of the indicated genotypes. ( A - D ) Immunofluorescence for the PanIN marker CLDN18 (red), and the leukocyte marker CD45 (green), revealing association of leukocytes with PanINs in Ptf1a cKO; Kras G12D . ( E - H ) IHC for alpha-SMA, highlighting the activation of pancreatic stellate cells in Ptf1a cKO; Kras G12D pancreata. ( I - L ) Sirius Red staining, highlighting widespread fibrosis in Ptf1a cKO; Kras G12D . Scale bars: ( A - D ) 50 mum, ( E - L ) 200 mum. DOI: http://dx.doi.org/</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/14045182-26151762-CD45-elife07125fs008.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))" title="CD45 Antibody (14-0451-82) in IHC (P)"> <figcaption itemprop="caption">Figure 4--figure supplement 3. High-dose tamoxifen administration does not induce pancreatitis. ( A - D ) Lowand ( A' - D' ) high-magnification H&E staining of wild-type pancreata, fixed 24 hr after indicated treatment. ( E - H ) Immunofluorescence for CK19 (red), CD45 (green) and DAPI (blue), highlighting inflammatory cells in the exocrine pancreas. Scale bars: ( A - D ) 200 mum, ( A' - D' ) 100 mum, ( E - H ) 50 mum. DOI: http://dx.doi.org/</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15191_fmolb-08-737472-g007.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))" title="CD45 Antibody (14-0451-82) in IHC (F)"> <figcaption itemprop="caption">FIGURE 7 miR-223-5p antagonist promoted diabetic corneal epithelial wound repair and nerve regeneration by modulating inflammatory process. (A) Immunofluorescence corneal staining reflected CD45 protein expression in the normal mice (NW group), diabetic mice (DW group), diabetic mice subconjunctivally injected with miR-223-5p antagomir (DW + antagomir group) or antagomir NC (DW + NC group) 24 h post-injury. (B) qRT-PCR results revealing the CD45 mRNA expression of the corneal epithelium in each group. (C-E) qRT-PCR detected the mRNA expression of inflammatory factors including TNF-alpha, IL-1beta, and IL-6 in the corneal epithelium of these four groups at 24 h post-wounding. (B-E) Data were analyzed by one-way ANOVA. If significant, multiple comparations were then performed. * p -value of <0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15192_ijms-22-09484-g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))" title="CD45 Antibody (14-0451-82) in IHC (F)"> <figcaption itemprop="caption">Figure 2 Neutralization of extracellular ""Cold-inducible RNA-binding protein"" (eCIRP) decreases leukocyte accumulation in ischemic tissue. ( a ) The scatter plot displays the relative number of CD45 + (pan-leukocyte marker) cells (per mm 2 ) in the ischemic gastrocnemius muscles of mice that received phosphate-buffered saline (PBS), isotype antibody (ISO) (control groups), or the anti-CIRP antibody (Anti-CIRP) and were sacrificed 7 days after femoral artery ligation (FAL). Data are means +- S.E.M., n = 5 per group. n.s. p > 0.05, * p < 0.05 (PBS vs. ISO vs. Anti-CIRP) by one-way ANOVA with the Tukey's multiple comparisons test, a defined ischemic area (1.5 mm 2 ) of muscle tissue was analyzed per mouse. ( b ) Representative immunofluorescence staining of ischemic gastrocnemius muscles of mice treated with PBS (top), isotype antibody (middle), or anti-CIRP antibody (bottom) 7 days after FAL. Cells were stained with an antibody against CD45 (green) and DAPI (blue) to label nucleic DNA. Scale bars represent 50 um.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14904_biology-10-00472-g001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))" title="CD45 Antibody (14-0451-82) in IHC (F)"> <figcaption itemprop="caption">Figure 1 Induction of EAE and IL-16 production by tissues of EAE mice. ( A ) C57BL/6J female mice were injected with MOG 35-55 emulsified in CFA, together with PTX. Clinical symptoms were recorded over the course of 26 days. Control mice received PBS + CFA + PTX immunisation. N = 15. Statistical significance was determined by one-way ANOVA with repeated measures and Bonferroni post-hoc tests. ** p < 0.01, *** p < 0.001. ( B - D ) CNS tissues were harvested from PBS control mice on day 16 and EAE mice on day 12, day 16 and day 26. Spinal cord ( B ), hippocampus ( C ) and cerebellum ( D ) tissues were stained for CD45 and counterstained with haematoxylin. Representative images are shown. The percentage of CD45 + cells was quantified for each group; results are expressed as mean +- SEM. N = 3 for all groups. Statistical significance was determined by one-way ANOVA with Bonferroni post-hoc tests. ( E ) Spleen cell suspensions prepared from day 16 of PBS or MOG 35-55 immunised mice were incubated either with media alone or media containing MOG 35-55 (50 mug/mL), or ConA (50 mug/mL). Supernatants were collected after 72 h of culture and used to detect IL-16 production by ELISA. Results are expressed as the mean +- SEM. PBS n = 4 and EAE n = 6. Statistical significance was determined by one-way ANOVA with Bonferroni post hoc tests. ( F ) Supernatants from homogenised spinal cord, cerebellum or cerebrum were collected and prepared to analyse IL-16 levels by ELISA. PBS n = 3, EAE n =</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14904_biology-10-00472-g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))" title="CD45 Antibody (14-0451-82) in IHC (F)"> <figcaption itemprop="caption">Figure 4 Expression of IL-16 by infiltrating immune cells in EAE mice. Spinal cord and brains were harvested from EAE and PBS control mice. Tissue was co-stained with IL-16 (green) and CD45, CD4, or F4/80 (all red). Representative images of spinal cord ( A - C ), cerebellum ( D ) and hippocampus ( E ) tissues are shown. Dotted white lines indicate spinal cord section edges. White arrows indicate areas of colocalization. Percentage of double-positive cells in each group within the spinal cord ( A - C ), hippocampus ( F , G ) and cerebellum ( H , I ) were quantified with results expressed as the mean +- SEM. N = 5. Statistical significance was determined by one-way ANOVA with Bonferroni post hoc tests. * p < 0.05, ** p < 0.01, *** p < 0.001 versus PBS or comparison groups are indicated by the bar lines.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/CD45_26147083_IF_10_nihms-687095-f0007_20180524.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))" title="CD45 Antibody (14-0451-82) in IHC (F)"> <figcaption itemprop="caption">Extended Data Figure 3 Basal stem/progenitor cell ablation promotes the differentiation of secretory cells into ciliated cells without affecting the mesenchyme a, Immunostaining for YFP lineage label (green) and the ciliated cell marker C-MYB (red) in SCGB1A1-YFP; CK5-DTA mice (n=3 mice). White arrowheads point to double positive cells. b, Immunostaining for YFP lineage label (green) and the ciliated cell marker ACTUB (red) using SCGB1A1-YFP; CK5-DTA mice (n=3 mice). c, Flow cytometry analysis for lineage labeled YFP + cells (x axis) and CD24 + ciliated cells (y axis) cells from control iPBS-treated or Dox-treated SCG1A1-YFP; CK5-DTA mice. d, Quantification of the percentage of FOXJ1 + cells per total DAPI + cells in tracheal sections from control iPBS-treated or iDOX-treated SCG1A1-YFP; CK5-DTA mice (n=3 mice). On the right, absolute numbers of FOXJ1 + cells per tracheal section (n=3 mice). e, H&E staining of tracheal sections following basal cell ablation. f, Immunostaining for CD45 + hematopoietic cells (left panels), CD31 + endothelial cells (middle panels) and SMA + smooth muscle cells (right panels) (green) in control or basal cell-ablated trachea (n=3 mice). All analyses were performed 3 days after cell ablation. Nuclei stained with DAPI (blue). n=biological replicates/condition. Two independent experiments. ** p<0.01. Data shown in the graphs are means +- SEM. Scale bar, 20mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/14045182-22363815-CD45-pone0032193g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))" title="CD45 Antibody (14-0451-82) in IHC (F)"> <figcaption itemprop="caption">Figure 4 Skin pathology in OX40 Cre Ikbk2 fx/fx mice is not T cell dependent. (A) Photograph shows skin pathology in a representative Rag1 -/- OX40 Cre Ikbk2 fx/fx mouse (fx/fx) compared with a littermate Rag1 -/- OX40 Cre Ikbk2 fx/wt control (fx/wt). White dotted line indicates the border between dermis and epidermis. (B) Images show skin sections from 12-16 week old mice of the indicated strain stained with H&E and taken at 10x magnification. (C) Confocal images of skins sections from 12-16 week old mice of the indicated mice stained for expression of CD45, cytokeratin 5 or cytokeratin 6 (red) and counter stained with DAPI. White scale bar indicates 10 um size. (D) Graph shows progress of disease development in Rag1 -/- OX40 Cre Ikbk2 fx/fx mice (blue, n = 18) as compared with Rag1 sufficient OX40 Cre Ikbk2 fx/fx mice (black lines, n = 9). (E) Bar chart shows mean time of disease progression to score 2 in Rag1 -/- OX40 Cre Ikbk2 fx/fx mice as compared with Rag1 sufficient OX40 Cre Ikbk2 fx/fx mice. Data are representative (A-C) of three independent experiments or are pooled (D-E) from three independent experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/14045182-22363815-CD45-pone0032193g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (Frozen) (IHC (F))" title="CD45 Antibody (14-0451-82) in IHC (F)"> <figcaption itemprop="caption">Figure 2 OX40 Cre Ikbk2 fx/fx mice exhibit skin epidermis hyperplasia. (A) Images show skin sections from 12-16 wk old mice of the indicated strain stained with H&E and taken at 10x magnification. White dotted line indicates the border between dermis and epidermis. (B) Confocal images of skins sections from 12-16 week old mice of the indicated mice stained for expression of CD45, cytokeratin 5 or cytokeratin 6 (red) and counter stained with DAPI. White scale bar indicates 10 um size. Data are representative of 3 independent experiments and at least two mice per strain experiment.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20585_gr4.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Characteristics of the corpus tissue of 6-month-old RUNX3 R122C/R122C mice. ( A ) Representative macroscopic images of the corpus of 6-month-old WT and RUNX3 R122C/R122C mice. ( B ) H&E staining of the corpus of 6-month-old WT and RUNX3 R122C/R122C mice. ( C ) IF staining for Atp4a and GSII in the corpus. ( D ) IF staining for GIF, Muc5ac, E-cadherin (E-cad), and chromogranin A (ChgA) in the corpus. ( E ) Quantification of the numbers of parietal, mucous neck, and chief cells per gland in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( F ) qPCR for Muc6 , Atp4a , and Gif expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n = 3 mice each). ( G ) H&E staining of the gland base in 6-month-old WT and RUNX3 R122C/R122C mice. ( H ) IF staining for CD45 and E-cad in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( I ) qPCR for Il6beta and Tnf expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n = 3 mice each). Scale bars : 5 mm ( A ), 100 mum ( B-D , G , and H ). Data are presented as the means +- SEM and were analyzed by the Student t test. * P < .05, *** P < .001. DAPI, 4',6-diamidino-2-phenylindole.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20585_gr5.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Features of the corpus tissue of 6-month-old RUNX3 R122C/R122C mice. ( A ) qPCR for Muc5ac and Chga expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n = 3 mice each). ( B ) IF staining (XZ-section) for Ki67, GSII, and CD45 in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( C and D ) IF staining for ( C ) CD68 and ( D ) F4/80 and E-cad in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( E ) IF staining for F4/80, CD163, and E-cad in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice. ( F ) qPCR for Il1b and Ptgs2 ( Cox-2 ) expression levels in the corpus tissues of 6-month-old WT and RUNX3 R122C/R122C mice ( n = 3 mice each). Scale bars : 100 mum ( B , C , and E ), 50 mum ( D ). Data are presented as the means +- SEM and were analyzed by the Student t test. * P < .05. DAPI, 4',6-diamidino-2-phenylindole.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)" title="CD45 Antibody (14-0451-82) in IHC, Flow"> <figcaption itemprop="caption">Fig. 1 Isolation and characterization of mesenchymal stem cells. a Schematic showing isolation of mouse bone marrow cells (BMCs) and its properties of self-renewal and differentiation of MSCs. b Representative microscopic images displaying isolated bone marrow cells that show circular and round-shaped morphology of BMCs; whereas, adhered MSCs show fibroblast or eye-shaped morphology. c Immunofluorescence images of MSCs showing the expression of MSC-positive markers (CD29, CD44, and SCA1). d Immunophenotypic characterization of MSCs using flow cytometer showing the absolute counts of MSC positive markers such as CD29, CD44, and SCA1, as well as expression of MSC-negative (CD34, CD45, and CD11b). Isotype controls for each antibody were used as controls and FITC/rhodamine-conjugated secondary antibodies were used for their detection. e Bar graph (quantification from four independent experiments (expressed as mean +- standard error)) showing the percentage of cells expressing the MSC-positive and negative markers respectively. f , g Immunophenotypic characterization of BMCs using flow cytometer showing expression various markers (CD29, CD44, CD45, and CD11b). Bar graph expressed as mean +- standard error shows quantification of respective markers from three independent experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20583_urn-x-wiley-02709139-media-hep32083-hep32083-fig-0005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">5 FIG. Sab knockdown prevents decreased energy expenditure, hepatic inflammation, and fibrosis. Feeding and ASO as in Fig . 4. (A) Immunoblot of JNK, p38, ATF2, and MKK4 and phospho-forms, and Col1alpha. beta-actin is the loading control. Each line represents a single mouse liver (n = 4 mice/group). Representative images of three separate blots. Regression plot of EE (B,C) and residual EE (D,E) before and after ASO treatment of the same mice. Regression plot of residual EE against fat mass. Mean values of residual EE are shown as (Delta). # P < 0.05 EE in HFHC versus chow-fed groups. * P < 0.05 EE of mice after versus before ASO treatment by ANCOVA (n = 5-6 mice/group). (F) Representative immunohistochemistry of liver sections from Control-ASO ( Ctl-ASO ) or Sab-ASO treated mice fed the HFHC diet for 30 weeks. CD45, CD68, MPO, F4/80, TNF, and alpha-SMA stained in formalin-fixed paraffin-embedded tissue sections and color developed by DAB substrate (n = 5-6 mice/group). Scale bar = 100 um.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19135_urn-x-wiley-00223417-media-path5768-path5768-fig-0002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">2 Figure LEC-specific mTOR deletion results in elevated numbers of F4/80+ macrophages in the liver. (A) IHC for F4/80 and CD45 in liver sections from WT and mTOR LEC mice (scale bar = 100 mum). (B) Positive cells were counted using ImageJ software, normalized to number of cells per field of view and shown as bar charts. Mean +- SEM, statistically analyzed using unpaired two-sided Student's t- test, *** p < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15188_ijms-22-05800-g003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 3 C3-/- mice show enhanced infiltration of leukocytes. ( a ) The scatter plot shows leukocytes (CD45 + ) per mm 2 in ischemic gastrocnemius muscles isolated at day 7 after FAL. Data shown are means +- SEM, n = 5 per group, a defined ischemic area (1.5 mm 2 ) of muscle tissue was analyzed per mouse. **** p < 0.0001 (WT vs. C3-/-) by unpaired Student's t -test. ( b ) Representative immunofluorescence pictures of analyzed gastrocnemius muscles of WT (upper picture) and C3-/- mice (lower picture) 7 days after FAL. Cells were labeled with antibodies targeting CD45 (green) and with DAPI (blue) to label nuclei. Scale bars: 20 um.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15186_40478_2021_1186_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig. 1 VISTA is differentially expressed in distinct MS lesion stages and decreases in EAE. a Representative images of in situ expression of VISTA in distinct MS lesion stages. b Quantification of the area positive for VISTA in MS lesion stages compared to normal-appearing regions shown as log fold change. At least 3 images were taken from each lesion and the area positive for VISTA was measured. Statistical analysis performed was a Wilcoxon signed-rank test comparing lesions to normal-appearing areas with Benjamini-Hochberg correction for multiple comparisons (n = 5 for each lesion). (c) VISTA geometric mean fluorescence intensity (gMFI) on viable (DAPIneg) microglia (CD45intCD11BposLY6Cneg) during different stages of EAE including score 1(E1: early disease) score 4 (E4: peak disease), and chronic EAE (Ech), and unimmunized control (c) mice. Error bars indicate mean +- s.d. (n = 5-6). Statistical analysis performed was a one-way ANOVA with Dunnett's correction for multiple comparisons. d Fold change in VISTA expression in primary neonatal mouse microglia 5 h after stimulation with LPS, Pam3CSK4, PolyI:C, myelin, IL1b, or TNFa, measured by RT-qPCR and normalized to Hprt1. Error bars indicate mean +- s.d. (n = 3-5). Statistical analysis performed was a one-way ANOVA with Dunnett's correction for multiple comparisons. Boxes indicate median and lower and upper quartiles, whiskers show min/max, and outliers are indicated by points. ns = not significant, * p < 0.05, ** p < 0.01, *</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12874_biomedicines-09-00395-g003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 3 Cold-inducible RNA-binding protein (CIRP) knockout decreases leukocyte infiltration in ischemic tissue. ( a ) The scatter plot displays the relative amount of CD45+ (pan-leukocyte marker) cells (per mm 2 ) of ischemic gastrocnemius muscles of wildtype and CIRP -/- mice 7 days after femoral artery ligation (FAL). Data are means +- S.E.M., n = 5 per group. * p < 0.05 (CIRP -/- vs. control) by unpaired, two-sided student''s t-test. ( b ) Representative immunofluorescence stainings of ischemic gastrocnemius muscles of CIRP wildtype control (left) and CIRP -/- (right) mice 7 days after FAL. Smaller images display single channels, large images merged channels of leukocytes (anti-CD45, green) and nucleic acid (DAPI, blue) stains. Scale bars 50 um.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19145_gutjnl-2020-321112f06.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 6 Elimination of senescent cells blocks PanIN development and reduces PDAC incidence. (A) Timeline of caerulein and repeated ABT-737 treatments during PanIN and PDAC formation period. ABT-737 was administered for 2 days every month, for four consecutive months, and mice were either sacrificed after the last treatment (point 1), or maintained for a further 3.5 months (point 2). (B) Representative images of pancreatic sections from time point one stained for CK19, SA-betaGal and CD45, labelling hematopoietic cells. (C) Percentage of tissue area containing ADM and PanIN lesions in mice treated with ABT-737 (n=6) or vehicle (n=3). Values indicate mean per group +-SE. (D) Levels of cytokines and chemokines in pancreata of Pdx1-Cre +/- ; LSL-Kras +/G12D mice treated with ABT-737, as measured by cytokine array. Values are shown relative to levels in vehicle-treated mice (pool of 3 mice per group). (E) Percentages of mice treated with ABT-737 or with vehicle that showed PDAC formation upon sacrifice at time point 2. Images show representative whole pancreas from mice in each group. Arrow indicates a large PDAC lesion. *P<0.05, chi 2 test between ABT-737 and vehicle treated groups. (F) Pancreas to body-weight ratio in same mice as in (E). Values indicate mean across mice +-SE, n numbers as in (E). (G) Representative images of pancreatic sections from time point two stained as indicated. (H) Percentage of tissue area occupied by ADM, PanINs or PDAC in the same mice. *P<0.05, t t</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15170_12974_2020_2060_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig. 3 USUV isolates differentially induce cellular infiltration, apoptosis, and inflammation in the mice brain. a Left panel: Immunohistochemical CD45 staining (associated with luxol blue) showing inflammatory infiltrates in the infected brain (brown staining) at 6 dpi. Some cells present caspase 3 staining after immunohistochemistry. Right panel: Quantification of CD45-positive cells and caspase 3 positive cells in USUV-infected brain compared to CT. b qRT-PCR analysis of TNFalpha, IL6, IFNbeta, and IL1beta mRNA from the brain collected at 6 dpi. Each histogram represents the mean +- SEM from 6 independent mice normalized to CT. * p < 0.05 and ** p < 0.01</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g007.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig 7 USUV induces strong inflammatory responses in mouse eyes and efficiently replicates in human retinal pigment epithelium. (A) Representative photograph demonstrating ocular pathology and exudate in Ifnar -/- mice inoculated intraperitoneally with USUV at 10 4 TCID50/mouse. (B) Histological sections of uninfected (CT) or USUV-infected (6 dpi) neonatal mouse eye stained with haematoxylin/eosin/saffron and (C) immunohistochemical CD45 staining showing inflammatory infiltrates in neonatal eyes. Disruption of both inner and outer retinal structure and loss of photoreceptors layer were observed. INL: inner nuclear layer. ONL: outer nuclear layer. PL: photoreceptors layer. (D) Immunofluorescence staining shows microglia recruitment/activation in eyes of infected mice (Iba1: purple, nuclei: false colored green). Scale bar = 50mum. (E) qRT-PCR analysis of CXCL10, CCL5, IL6, IFNalpha and TNFalpha mRNA collected at 6 dpi from eyes of control and infected mice. *p <0 .05. (F) IPSC-derived-RPE were infected with USUV at MOI 0.2. Viral titers from apical and basolateral compartments of RPE grown on cell culture inserts were measured at 4 dpi and 7 dpi. Results are expressed as mean +- SEM of 3 independent experiments. (G) Fold regulation of statistically significant genes modulated at 2 dpi normalized to CT in USUV-infected RPE by qRT-PCR analysis using a specific interferons and receptors PCR array. Results are expressed as means of the fold regulation for 3 independent experiments a</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig 4 USUV induces massive brain inflammation. Histological sections of neonatal brain mice infected by USUV (6 dpi). (A) Immunohistochemical staining of B-cells (PAX 5), T-cells (CD3) and macrophages (F4/F80) showing T-cells and macrophages infiltration. (B) Immunofluorescence staining (Iba1 in pink, nucleus in green) shows microglia recruitment/activation in USUV-infected brain contrary to control mice (CT). (C) RT-qPCR analysis using a specific inflammatory cytokines and receptors PCR array of mRNA collected at 6 dpi from brain of control and infected mice. Fold regulation of statistically significant genes normalized to CT are indicated for 3 mice of each group. p <0.05 (p value in S3A Fig ). Scale bar = 50mum. (D) CXCL10 protein level in control and infected mice. (E) Representative picture of dissected brain from EB-injected mock- and USUV- infected mice at 3 and 6 dpi showing no blue labelling. Liver is used as positive control of EB staining.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig 3 USUV induces apoptosis and cellular infiltration in the mouse brain. ( A) Transverse sections of the brain (thalamus) of USUV-infected and control (mock, PBS injected) mice at 6 dpi stained with haematoxylin/eosin/saffron. We observe cellular infiltration and cell shrinkage. CT = control mice. (B) Some cells present nuclear condensation and caspase 3 staining after immunohistochemistry, suggesting apoptotic process in USUV-infected mice. Right panel: zoom on apoptotic cell. Arrows indicate apoptotic cells. (C) Immunohistochemical CD45 staining (associated with luxol blue) showing massive inflammatory infiltrates in multiple areas of the infected brain. (D) Quantification of CD45 positive cells in different brain area. Cor: Cortex, Cer: Cerebellum, Hyp: Hypothalamus, Hip: Hippocampus, Str: Striatum, Tha: Thalamus. (E) Immunohistochemical staining of viral antigen and CD45. The majority of infected cells are not inflammatory cells.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12870_pntd.0008223.g006.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig 6 USUV induces spinal cord inflammation. (A) Immunofluoresence of control (CT) and USUV-infected spinal cords of Swiss mice at 6 dpi. The virus is labeled using a pan-flavivirus antibody (green) and nuclei by DAPI (blue). Scale bar = 20 mum. (B) Immunofluoresence CD45 staining showing inflammatory infiltrates in infected-spinal cord (C) not associated with USUV staining (adjacent sections). Scale bar = 15 mum in panel B and 50 mum in panel C. (D) Immunofluoresence caspase 3 staining showing apoptosis in infected-spinal cord. Arrows indicate apoptotic cells. Scale bar = 20 mum. (E) RT-qPCR analysis using a specific inflammatory cytokines and receptors PCR array of mRNA collected at 6 dpi from the spinal cord of control and infected mice. Fold regulation of statistically significant genes normalized to CT are indicated for 3 mice in each group. p <0.05 (p value in S3B Fig ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9912_41467_2020_15129_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig. 4 cGAS-STING pathway is essential for TMZ and anti-CD47 induced immune response. a Combination TMZ and anti-CD47 antibody treatment against murine GBM cells (GL261) increased the production of type I interferons in APCs. IFNA interferon alpha , IFNB interferon beta . n = 5, ** p < 0.01, one-side ANOVA with Bonferroni post hoc correction. b Western blot showing combined TMZ and anti-CD47 antibody treatment resulted in the activation of cGAS-STING cytoplasmic DNA sensing pathways in BM APCs. c Combination TMZ and anti-CD47 antibody treatment promoted p65 expression and nuclear translocation in BM APCs that is dependent on STING. d STING activation is critical to the increased the production of NF-kappaB cytokine TNFalpha and IL1beta in APCs in the setting of combined TMZ and anti-CD47 antibody treatment. n = 6, ** p < 0.01, unpaired Student''s t test. e Immunofluorescence staining of GL261 tumors implanted in WT and STING KO animals. Nuclear p-IRF3 (Ser 396) in CD45 + cells is indicative of STING signaling activation. f , g Quantification of CD45 + cell infiltration and percentage of p-IRF3 positive CD45 + , C57BL/6, n = 7; knockout, n = 6. Unpaired Student''s t test. h GL261 tumor volume in C57BL/6 or STING KO mice at day 20 following control or combination TMZ + aCD47 treatment, n = 5/group. i T-cell infiltration in GL261 tumors in C57BL/6 or STING KO mice at day 20 following control or combination TMZ + aCD47 treatment measured by CD3 + cells in total DAPI count per fie</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_6006_elife-48448-fig3.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 3. The MC903 model induces rapid and robust changes in neuronal tissue. ( A ) Exact permutation test (10,000 iterations, see Materials and methods) for significance of mean absolute log 2 fold change in gene expression at Day 8 (MC903 vs. ethanol) of custom-defined groups of genes for indicated categories (see Figure 3--source data 1 ). ( B ) Log 2 fold change in gene expression (MC903 vs. ethanol) in mouse trigeminal ganglia (TG) at indicated time points for all genes which were significantly differentially expressed for at least one time point in the MC903 model. Green bars = increased expression in MC903 relative to ethanol; magenta = decreased expression. Exact values and corrected p -values are reported in Figure 3--source data 2 and Source Data 1 Supplemental Data, respectively. ( C ) Representative composite images showing immune cells (CD45, green), and sensory neurons (Prph, magenta) with DAPI (blue) in sectioned trigeminal ganglia from mice treated with Vehicle or MC903 for five days on the cheek. ( D ) Quantification of images examining average number of CD45 + cells per section and average ratio of CD45:Peripherin cells per section after five days of treatment (p=0.562 ( t = 0.6318, df = 4), 0.542 ( t = 0.6660, df = 4); two-tailed unpaired t-tests, n = 33-159 fields of view (images) each of both trigeminal ganglia from three mice per condition treated bilaterally). ( E ) Representative composite images showing immune cells (CD45, green), and sensory neurons</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/pone.0206539.g002-20-20190221105219.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig 2 Morphology of serially transplanted cervical cancer PDXs. A) representative example of an H&E stained cervical squamous cell carcinoma sample showing morphology of the tumour biopsy, primary, secondary and tertiary PDXs. B) Typical examples of negative staining for anti-human CD45 staining (second column), and anti-mouse CD45 (third column). Insets show examples of CD45 positive staining in human cervix biopsies and mouse kidney Scale bars 50 mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9900_F1.small.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12744_jci-128-97720-g330.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/41388_2018_313_Fig3_HTML-20-20190221105219.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Fig. 3 Par3 and aPKClamda control carcinogen-induced inflammatory signaling but not early immune cell recruitment. a Quantification of immunofluorescence analysis as previously described (2B) for p-p65 (S468) (Cell Signaling Techn. #3039) on paraffin sections of mice 24 h after DMBA treatment (% of DAPI positive cell nuclei; mean +- SEM; * p < 0.05, ** p < 0.01; one-way ANOVA/Tukey's post-hoc test). b Quantification of western blot analysis for total p65 protein in epidermal lysates of mice 24 h after DMBA treatment (mean +- SEM; * p < 0.05, ** p < 0.01; one-way ANOVA/Tukey's post-hoc test). Sample preparation and western blot analysis was performed as previously described [ 17 ]. c Quantification of immunofluorescence analysis as previously described (2B) for p-STAT3 (Y705) (Cell Signaling Techn. #9145) on paraffin sections of short-term DMBA/TPA treated mice (% of DAPI positive cell nuclei; mean + SEM; ** p < 0.01, *** p < 0.001; P58: n ( Cre ctrl) = 5, n ( Par3 eKO) = 4, n ( aPKClamda eKO) = 3, n (edKO) = 5; 24 h post-DMBA: n ( Cre ctrl) = 3, n ( Par3 eKO) = 4, n ( aPKClamda eKO) = 4, n (edKO) = 3; short-term DMBA/TPA: n ( Cre ctrl) = 5, n ( Par3 eKO) = 5, n ( aPKClamda eKO) = 4, n (edKO) = 4; one-way ANOVA/Tukey's post-hoc). For short-term DMBA/TPA treatments, at P58 mice were treated with a single dose of DMBA (40 mug in 200 mul acetone, Sigma) and three applications of TPA (200 mul of 10 -4 M TPA/acetone) at P65, 68 and 72, and killed 2 days a</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/dvdy24634-fig-0002-1-20190103084817.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15160_jnc14220-fig-0005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Leukocyte infiltration into the perilesional tissue is not altered by DMF . (a) Low power magnification showing the lesion core and the perilesional area in the cerebral cortex of a DMF -treated mouse at 4 dal. Immunohistochemistry using antibodies specific to CD 45 (red) or Iba-1 (green) indicates the presence of double-immunolabeled microglia/macrophages and leukocytes immunolabelled by anti- CD 45 only. The boxed region is shown in higher magnification (b). Arrows depict CD 45 + /Iba-1 - leukocytes at perilesional sites. (c) Increased numbers of CD 45 + leukocytes in the perilesional tissue of DMF - and vehicle-treated mice compared to corresponding tissue regions in sham mice at 4 dal. No significant difference was observed between DMF - and vehicle-treated mice (sham: n = 6 mice, vehicle: n = 10; DMF : n = 10). Scale: 100 mum (a), 50 mum (b). Statistical significance was calculated by Kruskal-Wallis test and values were adjusted for multiple comparisons by Dunn`s test (* p = 0.05).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3398_srep42195-f2.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 2 HC-HA/PTX3 reduces infiltration of inflammatory and immune cells into lacrimal glands of cGVHD mice. Lacrimal glands collected at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3, were sectioned for H & E staining ( a , b) , scale bar = 50 mum), immunofluorescence staining against CD45 (Red), CD4 (Green), IL-17 (White) ( c , d ), MHC class II (Red) ( f , g ), and DAPI nuclear staining (Blue) ( c - h) , scale bar = 20 mum), and transmission electron microscopy ( i and j) , Ac: acinus; red arrows: infiltrating inflammatory cells; asterisks: capillary; scale bar = 10 mum). Immunostaining for CD45 (red) and cell nuclei (blue) ( k and l) , scale bar = 20 mum). The number of CD45 + cells per field at x200 magnification in the HC-HA/PTX3- and PBS-treated groups were counted at least 5 different field on 4 sections ( m ), ** p = 0.015, N = 4 for each group).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3398_srep42195-f5.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 5 HC-HA/PTX3 suppresses inflammation and fibrosis in conjunctiva of cGVHD mice. Conjunctiva harvested at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3, were sectioned for H & E ( a and b) , Scale bar = 100 mum) and Mallory staining ( c and d ), Scale bar = 100 mum) and immunostaining for CD45 + cells (red) ( e and f ), MHC class II + cells (red) ( g and h ) and HSP47 + activated fibroblasts (green) ( i and j ) for both groups (Scale bar = 50 mum for ( e - h ). The number of HSP47 + cells/field was compared between the two groups ( **p = 0.005, N = 4 for PBS and N = 4 for HC-HA/PTX3).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/CD45_28165063_IF_9_srep42195-f4_20180524.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 4 HC-HA/PTX3 suppresses inflammatory cell and fibrocyte infiltration into lacrimal glands of cGVHD mice. Lacrimal glands collected at Day 32 after BMT, i.e., 4 days after the last injection of PBS or HC-HA/PTX3 were sectioned for immunostaining of CD45 (red)/CD34 (green) ( a , d ), CD45 (red)/collagen type I (green) and CD34 white ( b , e ), and CD45 (red)/CXCR4 (green) and CD34 (white) ( c , f ). Scale bar = 20 mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/CD45_27165837_IF_9_nihms782512f7_20180524.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3018_nihms779554f4.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)" title="CD45 Antibody (14-0451-82) in IHC, Flow"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry and Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12862_nihms746518f5.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 5 Increased leukocyte infiltration and inflammation in tumors from PIK3CA- GEMMs (a) Detection of leukocyte subtypes in tumors from PIK3CA -GEMMs and control mice using IHC with CD45, F4/80, Gr1, and CD11b. Scale bar: 50 muM. (b) qRT-PCR examination of inflammatory-related cytokines/chemokines and receptors. Results are averages of triplicate experiments. *p<0.05 (n=6 for each group).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/pnas1517188113sfig03-20180918151446.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/48045182-26136374-CD45-embr0016-1037-f6.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_2307_nihms562085f1.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12853_pone0052037g001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Figure 1 Whole mount in situ immunohistochemistry of gd7.5 B6 implantation sites co-stained with PE-CD31 (red) and FITC-CD45 (green). Low power image (A) is a for orientation. The mesometrial side of the uterus is uppermost; the central black region (*) represents the embryonic crypt. More CD31 expression is present mesometrially than anti-mesometrially or in lateral (L) decidua. Images B, D, F are of the same field (represented by the boxed M) of the mesometrial uterus. Images C, E, G are of the same field (represented by the boxed AM) from the anti-mesometrial uterus. Image (B) illustrates the larger, web-like, less linked vessels of the decidua basalis. These are distinctly different to the narrower, more frequently linked anti-mesometrial vessels shown in (C). (B) but not (C) contains high numbers of CD31+ leukocytes. Image (D) shows the enrichment of leukocytes in decidua basalis while image (E) shows that leukocytes present anti-mesometrially are less frequent and more heterogeneous in shape and size. Red and green are merged in images (F) and (G). Image (F) shows that many cells with co-expression of CD31+ and CD45+ are present mesometrially while image (G) shows their absence anti-mesometrially. Magnification bar in (A) is 200 um; in B-G 50 um.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12851_gr6.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/CD11b_22440612_IF_12_nihms361163f1_20180524.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12850_nihms264070f4.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/nfig003_015-25-20190103084817.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1480_nihms98872f8.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (IHC)" title="CD45 Antibody (14-0451-82) in IHC"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14977_41467_2021_23197_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))" title="CD45 Antibody (14-0451-82) in IHC (PFA)"> <figcaption itemprop="caption">Fig. 1 Generation and characterization of a genetic system for specific targeting of cavity macrophages. a Schematic figure showing CD45-Dre mediates Stop cassette removal from Gata6-iCreER and places CreER directly under Gata6 promoter. After tamoxifen (Tam), Cre-loxP recombination labels cells by tdTomato. b Intersectional genetics marks CD45 + GATA6 + cells as tdTomato + . c Schematic figure showing experimental design using cavity macrophage tracing tool CD45-Dre;Gata6-iCreER ( G6Mo-CreER ). d Flow cytometric analysis of the percentage of tdTomato + cells in macrophages from blood, pleural, and peritoneal cavity with or without Tam. e Immunostaining for tdTomato, CD11b, GATA6, F4/80 on dissociated cells from blood, pleural, or peritoneal cavity. Boxed regions are magnified. f Quantification of the percentage of tdTomato + cells in GATA6 + or F4/80 + macrophages. Data are the mean +- SD; n = 5 mice per group. g Quantification of the percentage of GATA6 + or F4/80 + macrophages in tdTomato + cells. Data are the mean +- SD; n = 5 mice per group. h FACS showing the percentage of tdTomato + cells expressing F4/80. i Whole-mount epifluorescence images and immunostaining for CD45 and tdTomato shows no resident tdTomato + macrophages in visceral organs. Each image is representative of 5 individual biological samples. Scale bars, yellow, 1 mm; white, 100 um. Source data are provided as a Source Data file.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19139_biomedicines-09-00157-g005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Western Blot (WB)" title="CD45 Antibody (14-0451-82) in WB"> <figcaption itemprop="caption">Figure 5 Pro-inflammatory phenotype of microglia in the PFC of DAT-/- rats. ( A ) Levels of CNS microglial marker CD45 were unchanged among the three genotypes. Morphometric analysis of Iba1 + cells showed ( B ) an increase in the total length extension of microglial processes of DAT-/- rats, ( C ) while mean maximum radius did not vary among genotypes. ( D ) Number of branches was significantly higher in DAT-/- rats. ( E ) Sholl analysis displayed higher number of intersections in Iba1 + cells in DAT-/- PFC. Individual data points are shown for each group. Data are presented as mean +- SEM, * p < 0.05, ** p < 0.001, *** p < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">3 Figure RBC-hitchhiking improves neoantigen-specific T-cell response of DNA nanovaccines A Scheme of the immunization procedure of RBC-Nanovaccines. B, C The expression of MHC I in CD11c + DCs and the percentage of CD45 + CD3 + , CD3 + CD4 + , and CD3 + CD8 + T cells in the spleen were analyzed by flow cytometry at the 11 th day after treatment with PBS, Nanovaccines, and RBC-Nanovaccines once or twice. n = 5 animals per group in (C); data were pooled from two independent experiments. D ELISA analysis of the concentration of TNF-alpha, IFN-gamma, and CRP in the peripheral blood of mice after different treatments ( n = 3-5 animals per group). E ELISPOT analysis of IFN-gamma spot-forming. F The corresponding quantification numbers of spots in (E). n = 5 animals per group; data were pooled from two independent experiments. Data information: Data in (C), (D), and (F) are presented as mean +- SD. Statistical significance was calculated by one-way ANOVA with Tukey's multiple comparison test in (C, D) and two-tailed Student's t -test in (F). * P < 0.05, ** P < 0.01 and *** P < 0.001. ns means no significant difference. Source data are available online for this figure.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24743_fphar-13-1095757-g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 2 Alteration of cellular composition in the diseased status of mice and humans. (A,B) Fractions of major cells types in aneurysmal aorta vs. the corresponding normal aorta of humans (A) and mice (B) . (C) Immunofluorescence analysis for SMMHC (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the human vascular media (scale bars: 100 mum). Lu means the lumen side of the vascular wall, and A means the adventitia side of the vascular wall. (D,E) Immunofluorescence analysis for vimentin (white) (D) and CD45 (purple) (E) and overlays with DAPI-labeled nuclei (blue) showing fibroblasts and immune cells in the human aorta (scale bars: 100 mum). (F) Immunostaining for calponin (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the mouse aortic media (scale bars: 100 mum). (G) Immunostaining for vimentin (white) and DAPI overlay in the thoracic and abdominal aorta form mice subjected to 4 weeks of Ang II induction (scale bars: 500 mum). (H) Immunostaining for CD45 (red), CD68 (green), and overlays with DAPI-labeled nuclei (blue) showing macrophages in the mouse aorta (scale bars: 100 mum). (I) Flow cytometry of the proportion of macrophages (F4/80 + CD11B + ), monocytes (LY6C + CD11B + ), and T cells (CD3 + ) in CD45 + immune cells among three groups (n = 3-4, per group).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24778_jci-132-160097-g179.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 GPR92 deficiency triggers proinflammatory responses and increases the expansion of M1-like IMs. ( A ) Flow cytometry analysis of CD45 + cells in the islets from WT or KO mice on a HFD, n = 6-4/group. ( B ) CD45 and CD11b double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n = 3-4/group. ( C ) F4/80 and CD11c double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n = 3-5/group. ( D ) Immunofluorescence of the pancreas. Scale bars: 20 mum. ( A - D ) Data and images are representative of at least 3 independent experiments. All data are expressed as mean +- SEM. *** P < 0.001, ** P < 0.01, * P < 0.05 by 2-way ANOVA with Bonferroni's post hoc. ( E ) Top 15 most-relevant, upregulated (red) and downregulated (blue) genes in the islet from WT versus KO mice on a HFD. Mean values from n = 4-5/group. ( F ) Volcano plot of the fold change ( x axis) versus adjusted (adj.) P value ( y axis) of the transcriptomes between the islets from WT and KO mice on a HFD. Genes highlighted in red or blue are based on the thresholds of log 2 fold change > 1 and adj. P < 0.05. ( G ) Pathways of the islets from WT versus KO mice on a HFD that were either activated (red) or repressed (blue) by lack of GPR92. Normalized enrichment score (NES) is represented in log 10 ( P ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g201.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx diaphragms. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45 + CD11b + LY6G - CD64 + F4/80 hi macrophages ( F ) from spironolactone-treated (SPR-treated) and prednisolone-treated (PRD-treated) 4.5-week-old mdx diaphragms compared with vehicle (VEH) controls. n = 6 replicates per group pooled from 2 mice each were used. ( G ) Quantification of myeloid cells, neutrophils (Nphi), infiltrating monocytes (Inf. MO), macrophages (MPhi), CD206 + macrophages (CD206 + ), and F4/80 hi macrophages represented as dot plots for cells per milligram of muscle (Cells/mg). ( H ) Bar graphs with individual data points as percentages of total CD45 + leukocytes (%CD45 + ), CD45 + CD11b + myeloid cells (%CD45 + CD11b + ), or macrophages (%CD45 + CD11b + LY6G - CD64 + ) comparing SPR- and PRD-treated mice with VEH controls. Experimental replicates are denoted by black and gray dots within the graphs. Statistics used were ANOVA with the BKY test * P <= 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g200.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx quadriceps. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45 + CD11b + LY6G - CD64 + F4/80 hi macrophages ( F ) from spironolactone-treated (SPR-treated) ( n = 13) and prednisolone-treated (PRD-treated) ( n = 13) 4.5-week-old mdx quadriceps compared with vehicle (VEH) ( n = 12) controls. ( G ) Quantification of myeloid cells, neutrophils (Nphi), infiltrating monocytes (Inf. MO), macrophages (MPhi), CD206 + macrophages (CD206 + ), and F4/80 hi macrophages represented as dot plots for cells per milligram of muscle (Cells/mg). ( H ) Bar graphs with individual data points as percentages of total CD45 + leukocytes (%CD45 + ), CD45 + CD11b + myeloid cells (%CD45 + CD11b + ) or macrophages (%CD45 + CD11b + LY6G - CD64 + ) comparing SPR- and PRD-treated mice with VEH controls. Experimental replicates are denoted by black and gray dots within the graphs. Statistics used were ANOVA with the BKY test * P <= 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">1 FIGURE Flow cytometry analysis of the CD11b+ cells. Cells isolated from non-perfused [(a)-(e)] and perfused [(f)-(j)] brains did not show significant differences. [(a), (f)] Histograms showing two CD45-expressing cell populations: CD45 low (microglia) and CD 45 high (possible macrophages). [(b), (g)] Microglia, identified as CD11b+ and CD45 low (Q3), comprised the highest proportion of cells (91.7%-94.5%), whereas a low percentage of potential macrophages (CD11b+/CD45 high, Q2) were observed. [(c), (h)] Forward scatter (FSC) analysis showing a slight smaller size of the CD45 low cells (red) respect to CD45 high (blue) cells. [(d), (i)] CD11b analysis showed a slight lower expression within CD45 low cells (red) respect to CD45 high (blue) cells. [(e), (j)] Forward scatter (FSC) and side scatter (SSC) characteristics of CD11b+/CD45 low (red) and CD11b+/CD45 high (blue) are shown</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20586_jciinsight-7-154824-g203.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Therapeutic potential of i.n. afatinib and pemigatinib application in acute EAE. ( A and B ) Clinical course (left) and linear regression analysis (right) of EAE in mice after daily i.n. treatment with vehicle, afatinib ( A ), or pemigatinib ( B ) starting from symptom onset. The experiment was repeated twice. Vehicle (PBS), n = 10; afatinib, n = 10; pemigatinib, n = 10. Data are reported as mean +- SEM. ( C ) Unsupervised clustering t-distributed stochastic neighbor embedding (t-SNE) plot overlaid with cluster and their abundance ( D ) identified by unsupervised PhenoGraph clustering of high-dimensional flow cytometry data obtained from CNS (brain and spinal cord) tissue at peak of disease from mice treated with afatinib ( n = 5) or vehicle ( n = 5). ( E and F ) Quantification ( E ) and scatter plots ( F ) of CD45 - CD11b - , CD45 int CD11b + , CD45 hi CD11b + , and CD45 + CD11b - cell populations in the CNS of mice treated with afatinib ( n = 5) or vehicle ( n = 5) at peak of disease. Two-way ANOVA with Sidak's multiple comparisons test. ( G ) Significant differences in CNS-resident and -infiltrating cell populations in mice treated with afatinib ( n = 5) or vehicle ( n = 5) at peak of disease, identified by SAM analysis () (FDR cutoff, 0.1). ( H and I ) Intracellular flow cytometry quantification of iNOS, TNF-alpha, and GM-CSF in astrocytes ( H ) and microglia ( I ) in mice treated with afatinib ( n = 5) or vehicle ( n = 5) at peak of disease. ( J ) Relative expression of</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_21405_jci-132-157338-g101.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Downregulated ZIP8/SIRT1 signaling and decreased renewal capacity of AEC2s from old mouse lungs. ( A ) Flow cytometry analysis to gate out total AEC2s (R2), and ZIP8 expression AEC2s (R3) from lung homologies of young and old mice. ( B ) Percentage of ZIP8 + cells (R3) within total AEC2s ( n = 5-6, ** P < 0.01). ( C ) Number of ZIP8 + cells recovered from young and old mouse lung ( n = 5-6, ** P < 0.01). ( D ) CFE of mouse AEC2s isolated from young and old mouse lungs ( n = 6-7, ** P < 0.01). ( E and F ) Flow cytometry analysis of ZIP8 expression in gated AEC2s cultured with medium only or medium containing 100 muM ZnSO 4 ( n = 6, *** P < 0.001). ( G - J ) 3D organoid culture of AEC2s isolated from lungs of 2.5-, 12-, 14-, and 18-month-old mice with and without 100 muM ZnSO 4 treatment. ( G ) CFE ( n = 3-4, * P < 0.05, *** P < 0.001, **** P < 0.0001 by ANOVA). ( H - J ) Expression of Slc39a8 ( H ), Sftpc ( I ), and Pdpn ( J ) in AEC2s derived from 3D-cultured organoids with and without ZnSO 4 treatment by qPCR ( n = 3-4, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 by ANOVA). ( K ) Violin plots of gene expression in AEC2s from lungs of bleomycin-treated young and old mice. ( L ) IPA pathway analysis of AEC2s from young and old mice on day 4 after bleomycin injury. ( M and N ) CFE of AEC2s from uninjured 10- to 12-week-old young mice treated with SRT1720 ( n = 3-6, ** P < 0.01, **** P < 0.0001 by ANOVA) ( M ) and splitomicin ( n = 5-6, **** P < 0.0001 by ANOVA) ( N</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Systematic quality evaluation of clinical-grade IL10-MSCs. A The IL10 protein level in the supernatant of different IL10-MSCs clones (P5-6). MSCs with blank vector transfection were the control. B With the increase in the number of passages, the IL10 secretion gradually decreased in IL10-MSCs, but still sustained a high level. C Morphological characterization of IL10-MSCs (P6) compared with naive MSCs (P6) under light microscopy. D Representative karyotype analysis. Control MSCs (left, P6) and IL10-MSCs (right, P6) both had normal karyotypes. E Flow cytometric analysis showed IL10-MSCs were positive (> 95%) for mesenchymal lineage markers (CD73, CD90, and CD105) and negative (< 2%) for hematopoietic and endothelial markers (CD14, CD19, CD34, CD45, and CD3) as well as for HLA-DR, in accordance with the criteria of clinical-grade MSCs. F1-2 Tumorigenesis analysis showed that there was no tumor formation observed in any SCID mice injected with IL10-MSCs, but tumor was formed in positive control SCID mice with HESCs transplantation. Further H&E staining showed no infiltration of tumor cells at the cell injection site and main organs after IL10-MSC injection. G - I Differentiation potential of IL10-MSCs in adipocytes, osteocytes, and chondrocytes stained with Oil red O, Alizarin Red, and Alcian Blue, respectively. IL10-MSCs maintained multiple lineage potential, but with downregulated adipogenic differentiation capability</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24777_ppat.1010342.g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.ppat.1010342.g002 Fig 2 Immune cell infiltration is impaired in BEX1 KO hearts during CVB3 infection. A) Hematoxylin and Eosin staining was conducted in WT and BEX1 KO mice following the indicated treatments. Scale bar = 125mum. B) The gating of CD45+ cells in representative WT and BEX1 KO 7 days post-infection hearts is shown for total leukocyte abundance using flow cytometry. D-K) Total Leukocytes (C), T lymphocytes (D), total monocytes (E), natural killers (F), B lymphocytes (G), myeloid-derived cells (H), neutrophils (I), infiltrating monocytes (J), and macrophages (K) were evaluated in WT and BEX1 KO hearts at the indicated post-infection time points using flow cytometry. d = days. Statistical analyses by 2-way ANOVA. (* p<0.05 CVB3-treated WT vs. uninfected WT; & p<0.05 CVB3-treated BEX1 KO vs. uninfected BEX1 KO; # p<0.05 BEX1 KO vs. WT same treatment).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19229_LSA-2021-01315_FigS1.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Figure S1. TNF inhibits M2 gene expression (related to Fig 1 ). (A) Gating strategy of wild-type BMDMs stained for Arg1, RELMalpha, and CD301. (B) Representative blots of wild-type BMDMs stimulated with IL4/IL13 or IL4/IL13 + TNF and percentages of RELMalpha + and CD301 + macrophages were determined by flow cytometry analysis. (C) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, or left untreated and percentages of CD301 + of F4/80 + macrophages were determined by flow cytometry analysis. (D) Representative blots for Fig 1D . (E) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, and/or Etanercept and percentages of Arg1 + of F4/80 + macrophages were determined by flow cytometry analysis. Data represent three independent experiments. (F) Gating strategy for the sorting of wound macrophages. Representative flow cytometry analysis of single cell suspensions isolated from Balb/c wild-type wound tissue at 14 dpi. 7-AAD - single cells were gated and analyzed for expression of CD45 and CD11b. 7-AAD - CD45 + CD11b + cells were gated and analyzed for expression of CD11b and F4/80. 7-AAD - CD45 + CD11b + F4/80 + cells were sorted by flow cytometry. (G) Gating strategy of small peritoneal macrophages from solvent or Etanercept-treated mice stained for Arg1 and RELMalpha. All values are means +- SEM; * P < 0.05; **** P < 0.0001. Statistically significant differences were determined by one-way ANOVA with Tukey correction. If not indicated otherwise superscripts</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 11 The mechanism of distant antitumor effect analysis. The flow cytometry images of DCs (CD80 + CD86 + ) mature ( A ) and quantitative analysis ( B ); flow cytometry ( C ) and quantitative analysis ( D , E ) of activated CD3 + CD4 + CD8 + T cells after each treatment; the population of CD4 + Foxp3 + Tregs in the spleen according to flow cytometry ( F ) and the ratio of CD3 + CD8 + cytotoxic T cells versus CD3 + CD4 + Foxp3 + Tregs ( G ); flow cytometry analysis of CD45 + , F4/80 + ( H ) and quantitative analysis ( I , J ) in the distant tumor</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19102_elife-73215-fig3.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3. Myofiber-specific ablation of IRE1alpha reduces abundance of satellite cells in injured muscle. ( A ) Representative photomicrographs of uninjured and 5d-injured TA muscle sections of Ern1 fl/fl and Ern1 cKO mice after immunostaining for Pax7 (red) and laminin (green) protein. Nuclei were identified by staining with DAPI. Scale bar: 50 um. White arrows point to Pax7 + satellite cells. ( B ) Average number of Pax7 + cells per field (~0.15 mm 2 ) in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. n = 6 mice per group. ( C ) Relative mRNA levels of Pax7 in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice assayed by performing qPCR (n = 3-5 mice in each group). ( D ) Representative immunoblots showing levels of Pax7 and unrelated protein GAPDH in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. ( E ) Primary mononuclear cells were isolated from TA muscle of Ern1 fl/fl and Ern1 cKO mice and subjected to FACS analysis for satellite cells. Representative FACS dot plots demonstrating the percentage of alpha7-integrin + cells in 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. ( F ) Quantification of alpha7-integrin + satellite cells in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice assayed by FACS (n = 4 or 5 mice in each group). Data are expressed as mean +- SEM and analyzed by one-way analysis of variance (ANOVA) followed by Tukey's multiple comparison test. * p <= 0.05, values significantly</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15194_fimmu-12-763067-g001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1 FCM analysis of dynamic changes of M1-like and M2-like uterine macrophages during the peri-implantation period in mice. (A) Gating strategy used to identify uterine M1-like macrophages (CD45 + F4/80 + CD206 - ) and M2-like macrophages (CD45 + F4/80 + CD206 + ) in pregnant mice. FSC vs SSC gating was used to clean up the debris and dead cells. CD45 + represents leukocyte; F4/80 + represents macrophages; CD206 - and CD206 + represent M1-like and M2-like uterine macrophages, respectively. (B) Dynamic changes of M1-like macrophages, M2-like macrophages and Mphi during peri-implantation period in mice (n>=3). Error bars represent means +- SEM; two-tailed unpaired t-test, ns, not significant, *P < 0.05 or ***P < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15193_gr4.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Figure 4 Cardiac-derived TGF-beta1 alters gene expression programs and inflammation in white adipose tissue. ( A ) Heat map generated using differentially expressed genes from RNA sequencing of perigonadal white adipose tissue (pgWAT) from WT and TGF mice under control and high-fat diet. ( B ) Gene ontology analysis comparing RNA sequencing of TGF and WT pgWAT under control and high-fat diet. ( C ) Body mass of WT and TGF mice following 2 weeks of control or high-fat diet. ( D ) Flow cytometry for CD45-positive cells (CD45+) in pgWAT from the indicated genotypes following 2 weeks of control or high-fat diet. ( E ) qPCR for CD74 normalized to Ppia housekeeping gene from pgWAT from the indicated genotypes following 2 weeks of control or high-fat diet. Statistics were calculated using a two-way ANOVA, where * indicates p < 0.05. Data are presented as the mean +- SEM. Group sizes are listed in the order of CD WT, CD TGF, HFD WT, and HFD TGF: (A, B) n = 3, 3; (C) n = 11, 13, 20, 15; (D) n = 4, 4, 4, 4; and (E) n = 12, 10, 11, 10. Figure 4</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 PTENalpha promotes tumor immune escape. a - g Cancer vaccination model of Mock or PTENalpha transfected Pten -/- B16 cells. a Schematic diagram of the cancer vaccine model. b Tumor volumes of C57BL/6 mice subjected to the cancer vaccination model were monitored overtime. The unimmunized group refers to mice without irradiated B16 cells immunization. The statistical significances between the immunized groups were indicated (PTENalpha-unimmunized, n = 4 mice; other groups, n = 5 mice, mean +- s.e.m., * P (d16) = 0.0254, * P (d20) = 0.0339, * P (d22) = 0.0487, * P (d24) = 0.0450, ** P = 0.0077). c The tumor-infiltrating lymphocytes (TILs) were isolated when the tumor volumes of the Mock-immunized group reach 200 mm 3 , and the cells were subjected to flow cytometry analysis. The cell counts of CD45 + cells were used for statistical analysis ( n = 4 mice, mean +- SD, ** P = 0.0044). Gating strategies were shown in Supplementary Fig. 3b . d - g TILs were isolated when the tumor volumes of Mock-immunized group reach 200 mm 3 , and CD45 + cells were sorted, using for 10x scRNA-seq with two replicates. 25,098 cells were identified as 12 clusters utilizing graph-based clustering. d Cd8T cells were further analyzed and identified as 4 clusters utilizing graph-based clustering. e Violin plot of differentiated genes in the 4 clusters of Cd8T cells. The color of each violin is the average expression value of a given gene. f and g Umap and proportion of the 4 clusters of Cd8T cells</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g006.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 4 Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 week ( right ) at 30 dpi. (b) Quantification of number of CD11b neg CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b neg -gated cells analyzed by CD8 vs CD45 staining. (d) Quantification of number of CD8 + CD45 + cells in each group. (e) Representative flow cytometry plots of CD8 + -gated cells analyzed by CD8 vs NS4B (WNV-specific tetramer) staining. (f, g) Quantification of (f) number and (g) percent of NS4B + of CD8 + cells in each group. (h) Representative flow cytometry plots of NS4B + -gated cells analyzed by IFNgamma vs NS4B staining. (i, j) Quantification of (i) number and (j) normalized MFI of IFNgamma + of NS4B + CD8 + cells. MFI was normalized within each experiment to the average IFNgamma MFI of NS4B + CD8 + cells isolated from 16 week mice at 30 dpi. Each mouse is represented by a symbol and lines indicate mean +- SD. These data are the representative of three independent experiments with a total of 9-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">4 FIGURE Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 week ( right ) at 30 dpi. (b) Quantification of number of CD11b neg CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b neg -gated cells analyzed by CD8 vs CD45 staining. (d) Quantification of number of CD8 + CD45 + cells in each group. (e) Representative flow cytometry plots of CD8 + -gated cells analyzed by CD8 vs NS4B (WNV-specific tetramer) staining. (f, g) Quantification of (f) number and (g) percent of NS4B + of CD8 + cells in each group. (h) Representative flow cytometry plots of NS4B + -gated cells analyzed by IFNgamma vs NS4B staining. (i, j) Quantification of (i) number and (j) normalized MFI of IFNgamma + of NS4B + CD8 + cells. MFI was normalized within each experiment to the average IFNgamma MFI of NS4B + CD8 + cells isolated from 16 week mice at 30 dpi. Each mouse is represented by a symbol and lines indicate mean +- SD. These data are the representative of three independent experiments with a total of 9-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">3 FIGURE Uninfected aged mice exhibit myeloid cells that lack typical microglial markers. Adult (16 week) and aged (85 week) mice were infected with 100 PFU WNV-NY via footpad inoculation. At 9 dpi, a time point just prior to when mice begin succumbing to viral infection, leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of percent of CD11b + CD45 + cells in 16 week mock, 85 week mock, 16 week infected, and 85 week infected cortex. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression. (d) Quantification of percent CD45 hi , P2RY12 + CD45 lo , and P2RY12 neg CD45 lo cells in each group. (e) Representative flow cytometry plots of P2RY12 + CD45 lo -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of percent MHCII + of P2RY12 + CD45 lo -gated cells in each group. (g) Representative flow cytometry plots of P2RY12 neg CD45 lo -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of percent MHCII + of P2RY12 neg CD45 lo -gated cells in each group. These data are representative of two experiments with 6-10 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. (i) Representative images of 16 week ( top row ) and 85 week ( bottom row ) cortical tissue sections collected fr</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g007.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 5 Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of number of CD11b + CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 + cells. (d) Quantification of number of P2RY12 + CD11b + cells in each group. (e) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs CD68 expression. (f) Quantification of number of CD68 + P2RY12 + cells in each group. (g) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of number of MHCII + P2RY12 + cells in each group. These data are the representative of two independent experiments with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. Exact p values noted; * p < 0.05; ** p < 0.01</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">5 FIGURE Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of number of CD11b + CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 + cells. (d) Quantification of number of P2RY12 + CD11b + cells in each group. (e) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs CD68 expression. (f) Quantification of number of CD68 + P2RY12 + cells in each group. (g) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of number of MHCII + P2RY12 + cells in each group. These data are the representative of two independent experiments with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. Exact p values noted; * p < 0.05; ** p < 0.01</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 6 Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 neg cells. (b) Quantification of number of P2RY12 neg CD11b + cells in each group. (c) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs CD68 expression. (d) Quantification of number of CD68 + P2RY12 neg cells in each group. (e) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of number of MHCII + P2RY12 neg cells in each group. These data are the representative of two experiment with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. Exact p values noted; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">6 FIGURE Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 neg cells. (b) Quantification of number of P2RY12 neg CD11b + cells in each group. (c) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs CD68 expression. (d) Quantification of number of CD68 + P2RY12 neg cells in each group. (e) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of number of MHCII + P2RY12 neg cells in each group. These data are the representative of two experiment with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. Exact p values noted; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15180_elife-66063-fig1.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1. Two cell populations with skeletal stem cell characteristics in postnatal long bones. ( A ) Diagram showing two previously described skeletal stem cell (SSC) populations and the downstream populations they generate, which were defined by the specific expression patterns of cell surface proteins. Top: SSC lineage tree of the osteochondral SSC (ocSSC) that gives rise to bone, cartilage, and stromal populations. Bottom: the lineage tree of the perivascular SSC (pvSSC) able to give rise to bone, cartilage, adipose tissue, and stromal populations. BCSP: bone cartilage stroma progenitor; CP: cartilage progenitor; APC: adipogenic progenitor cell; Pre-Ad. : pre-adipocyte; OPC: osteochondrogenic progenitor cell. ( B ) Representative flow cytometric gating strategy for the isolation of ocSSCs (top) and pvSSCs (bottom). ( C ) Representative confocal microscopy images of in vivo derived single-color clonal colonies of renal capsule-transplanted purified ocSSCs (left) and pvSSCs (right) derived from Actin-CreERt Rainbow mice. Three independent transplants per cell type under renal capsules were performed. ( D ) Renal capsule transplant-derived ossicles of purified GFP-labeled ocSSCs (top) and pvSSCs (bottom). Images show the photograph of the kidney with transplant (top left) and GFP signal of graft tissue (bottom left) as well as Movat pentachrome cross-section staining (right). ( E ) Quantification of ocSSC (top) and pvSSC (bottom) graft composition. Results of three separate</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Cell characteristics of bone marrow derived macrophages (BMDMs) and mesenchymal stem cells (MSCs). Phase contrast microscopic image of BMDMs 5 days after in vitro culture ( A ). Flow cytometric analysis of BMDMs for F4/80 ( B ). Flow cytometric analysis of MSCs for CD90, CD105, CD34, and CD45 ( C ). CXCL12 gene knockout in MSCs. Transfection of MSCs with a GFP-positive CRISPR/Cas9 plasmid to knock out CXCL12 gene ( D ). Western blotting for knockout efficiency ( E ). beta-actin was used as a control. CXCL12 measurement in the serum-free conditioned media of MSC CXCL12+/+ and MSC CXCL12-/- by ELISA ( F ). Each point indicates an experiment (horizontal lines: mean)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 3 Flow cytometry analyses of the hypothalamus ( A , B , E ), visceral fat pad ( C , F ), and peritoneal cavity (PEC, D , G ) demonstrated macrophage migration following HFD. E An example of flow cytometry gating, indicating the presence of the CD45 high macrophage population that can be distinguished from the CD45 low microglia specifically in the hypothalami of HFD male mice, but not in female mice. These populations were quantified and presented as the % of all live cells in A (macrophages, CD11b+CD45 high ) and B (microglia, CD11b+Cd45 low ). C Quantification of F4/80+CD11b+ macrophages in the stromal vascular fraction of visceral adipose tissue following Ctr and HFD in males (left) and females (right). F An example of the flow cytometry gating strategy from visceral fat. D , G Peritoneal cavity (PEC) cells were analyzed by flow cytometry (gating example G ) and the percent of F4/80+CD11b+ macrophages of all live cells are presented graphically in D , males on the left and females on the right. n=9-12 total, 3 repeats consisting of 3-4 mice per group. Statistical significance (*) between Ctr (gray bars) and HFD (black bars) were determined by Student's T test followed by Tukey's post hoc test</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Figure 2 The resident microglial population increases in proportion and total number in the ipsilateral thalamus at PSD 14. At PSD 14, brains were harvested for cell cytometry. Single cell suspensions were obtained from cortex and thalamus. Cells were stained with CD45 antibody and CD11b antibody to measure the number and percentage of microglia in thalamus . ( A ) Representative cell cytometry plots generated from ipsilateral cortex and thalamus from sham and PSD 14 brains. The percentage of microglia, peripheral myeloid cells (pMyeloids), and lymphocytes is indicated numerically on the plots. ( B ) Illustration showing location of cortex and thalamus harvest sites from brain sections corresponding to + 1 or - 2 mm from bregma. ( C ) Number of CD45 Int /CD11b + cells in cortex and thalamus for sham and PSD 14 brains. * P < 0.05, unpaired t test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">1 Figure Adipoq Cre targets BM adipose lineage cells FACS analysis of tdTomato + cells in the bone marrow cells (percentages represent average values). Immunofluorescence staining of aggrecan and DAPI of femur sections from Adipoq Cre ; R26 tdTomato mice. Scale bar = 200/100/50 um in left/ upper right/ bottom right images. CB: cortical bone, TB: trabecular bone. Immunofluorescence staining of RANKL and Hoechst in bone marrow cells from Adipoq Cre ; R26 tdTomato mice. Scale bar = 50 um. qPCR results of Rankl in BMAT and peripheral adipose tissues, including epididymal (eWAT), inguinal (iWAT), and interscapular (iBAT) ( n = 3 independent biological replicates). Data were compared using one-way ANOVA (** indicates P < 0.01), and error bars are standard deviations. Immunofluorescence staining of RANKL during in vitro adipogenesis of BMSCs from Adipoq Cre ; rankl fl/fl mice ( Rankl -/- ) and rankl fl/fl mice ( Rankl +/+ ). Scale bar = 50 mum. Western blotting analyses of RANKL in BMSCs during in vitro BMSCs adipogenesis ( n = 3 independent biological replicates). Data were compared using an unpaired t -test (** indicates P < 0.01), and error bars are standard deviations.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Genetic ablation of IL-6 reverses GBM immunosuppression. GBM was induced by RCAS-mediated genetic engineering in Ntv-a ; Ink4a-Arf -/- ; Pten fl/fl ; LSL-Luc donor mice, followed by orthotopic tumor implantation into Cdh5-Cre ERT2 ; Il6 fl/fl recipient mice that were pretreated with (IL-6-DeltaEC) or without (Control) tamoxifen. Two weeks after tumor implantation, tumors were excised. a Schematic approach. b , c Tumor-derived single-cell suspensions were analyzed by CyTOF. b Representative CyTOF sorting. c Quantitative results (mean +- SEM, n = 4 mice). Statistical analysis by two-tailed Student's t -test. d - f Tumor-derived single-cell suspensions were analyzed by flow cytometry. d Analysis for CD3 + T cells. Left, representative cell sortings. Right, quantified results ( n = 6 mice, mean +- SEM). Statistical analysis by two-tailed Student's t -test. e , f Analysis for e CD4 + /CD8 + T cells or f myeloid cells ( n = 6 mice, mean +- SEM). Statistical analysis by two-tailed Student's t -test. g , h Tissue lysates from normal brains and tumors were subjected to ELISA analysis for g IL-10 and h TGF-beta expression (mean +- SEM, n = 4 mice for IL-6-DeltaEC GBM group and n = 3 mice for other groups). Statistical analysis by two-way ANOVA with Sidak's test. Source data are provided as a Source data file.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (14-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 IL-6 neutralization enhances T-cell infiltration into GBM tumors and improves animal survival but does not sensitize tumor to immune checkpoint blockade. GBM was induced in WT B6 mice, followed by injection with control IgG, anti-IL-6 antibody (Ab), immune checkpoint inhibitors (ICIs), or ICIs plus anti-IL-6 Ab. a Schematic approach. b , c Survival and tumor growth analyses ( n = 8-12 mice, specific n numbers are shown in the figure). b Mouse survival was monitored for 60 days and subjected to two-sided log-rank Mantel-Cox analysis. MS, median survival. c Tumor volume was analyzed by bioluminescence imaging during days 13-23 (mean +- SEM). Statistical analysis by two-way ANOVA with Dunnett's test. d - g Tumors were excised 2 days after treatment. Tumor-derived single-cell suspensions were stained with antibodies against CD45, d CD3, e CD11b, f CD4, CD8, CD3, and g Ki67, IFN-gamma, and CD69, followed by flow cytometry analyses. d Analysis for CD3 + T cells. Left, representative cell sortings. Right, quantified results ( n = 6 mice, mean +- SEM). Statistical analysis by one-way ANOVA with Fisher's LSD test. e - g Quantified results for immune cells ( n = 6 mice, mean +- SEM). Statistical analysis by one-way ANOVA with Fisher's LSD test. Source data are provided as a Source data file.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8108_cancers-10-00403-g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody" title="CD45 Antibody (14-0451-82)"> <figcaption itemprop="caption">Figure 4 Regulation of CD45 + cell number by both MEK and Hh signaling pathways. ( A ) Representative immunofluorescent staining images of CD45 + cells in liver tissues after drug treatments. ( B ) Summary of A from 10 images in each group (from at least 3 mice) with the number of CD45 + cells per field under microscope (200x). ( C ) Summary of flow cytometry analysis of CD45+ cells in different treatment groups (from three mice/group). * indicates p < 0.05 and ** indicates a more than additive effect via BLISS independence analysis. {TM}</figcaption> </figure> </div> </div> </noscript> <div id="tf-related-products-container-new"></div> <div class="product-details"> <div class="container"> <div class="row"> <div class="large-span-12 medium-span-12 small-span-12"> <h2 class="pdp-sub-heading product_details_heading">Product Details</h2></div> <div class="hidden-sku"> <h2>14-0451-82</h2> </div> <div class="product-detail-section tested-app-section new-tbl-design product-detail-section table-spec"> <div class="product-container-head"> <div class="product-item"> Applications </div> <div class="product-item dilution-lbl-head "> Tested Dilution </div> <div class="product-item published-applications"> Publications </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Western Blot 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publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Miscellaneous PubMed (Misc)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Misc-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> </div> <div class="product-detail-section tested-app-section new-tbl-design product-specific-section table-spec"> <div class="product-container-head"> <div class="product-item">Product Specifications</div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Species Reactivity</h2> </div> <div class="product-item left-flex-cls"> <span title="Mus musculus">Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Published species</h2> </div> <div class="product-item left-flex-cls"> <span>Human,</span> <span>Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2> Host/Isotype</h2> </div> <div class="product-item left-flex-cls"> <span title="Rattus">Rat / IgG2b, kappa</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Class</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Monoclonal </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Type</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Antibody </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Clone</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 30-F11 </div> </div> </div> <div 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href="/antibody/product/62-0451-82"> Super Bright 436 <span class="conjugate-indicator" style="background-color:#3D00FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/63-0451-82"> Super Bright 600 <span class="conjugate-indicator" style="background-color:#FFBE00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/64-0451-82"> Super Bright 645 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/67-0451-82"> Super Bright 702 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/78-0451-82"> Super Bright 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li class="drop-down-link-ctnr"> <a class="conjugate-dropdown-link" href="/us/en/home/global/forms/antibody-conjugates-custom-form.html" ng-attr-target="$ctrl.getRequestCustomLinkTarget()">Request custom conjugation <svg class="svg-icon external-link-icon" ng-if="$ctrl.showExternalLinkIcon()"> <use href="#external-link"></use> </svg> </a> </li> </ul> </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Form</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Liquid </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Concentration</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.5 mg/mL </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Purification</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Affinity chromatography </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage buffer</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> PBS, pH 7.2 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Contains</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.09% sodium azide </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 4° C </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Shipping conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Ambient (domestic); Wet ice (international) </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"><h2>RRID <span id="rrid-tooltip" class="rrid-tooltip-icon" ng-include="'/order/genome-database/webapp/assets/core/img/svg/mono_tooltip.svg'" data-toggle="tooltip" ng-click="$ctrl.showRridTooltip()" close-tooltip="$ctrl.closeRridTooltip()" title="Research Resource Identifiers (#RRID) are ID numbers assigned to help researchers cite key resources in the biomedical literature to improve transparency of research methods."> </span></h2> </div> <div class="product-item left-flex-cls">AB_467251</div> </div> </div> <div class="product-specific-details"> <div class="product-specific-details-tbl product-specific-add-border" > <div class="product-info-para"> <h4 class="product-info-para-heading"> Product Specific Information </h4> <p>Description: The 30-F11 monoclonal antibody reacts with all isoforms of mouse CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.<br /><br />Applications Reported: The 30-F11 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunohistochemical staining. 30-F11 has also been reported in complement-dependent cytotoxicity. (Please use Functional Grade purified 30-F11 in functional assays).<br /><br />Applications Tested: The 30-F11 antibody has been tested by flow cytometric analysis of mouse bone marrow cells and splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br /><br />Purity: Greater than 90%, as determined by SDS-PAGE.<br /><br />Aggregation: Less than 10%, as determined by HPLC.<br /><br />Filtration: 0.2 µm post-manufacturing filtered.</p> </div> <div class="product-info-para"> <h4 class="product-info-para-heading"> Target Information </h4> <p class="product-specific-target-info">CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.</p> </div> <p class="product-details-regulatoryStmt">For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.</p> </div> <div class="product-detail-panel-builder"> <tf-promo-ad ng-if="$ctrl.showPromoAd" show-promo-ad="$ctrl.showPromoAd"></tf-promo-ad> </div> </div> </div> </div> </div> <div id="rootPdpDocLoader"></div> <div id="tf-related-products-container" ng-show="emptyRelatedProductsWidget === false" > <related-products-container ng-if="showRelatedProductsWidget === true" base-url="'/api/magellan/related-products-ui/widget/v2/'" product-type="'antibody'" product-sub-type="'primary'" product-id="'14-0451-82'" country-code="'sg'" iso-language="'en'" > </related-products-container> </div> <div class="tf-pdp-divider" ng-if="emptyRelatedProductsWidget === false" ></div> <div class="references reference-section-1" id="references-component-id"> <div id="references-section-id"> <reference-section ng-if="loadReferences" default-display-card-limit="3" reference-count="443" sub-type="'Antibody'" 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itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37735598"> <div itemprop="name">Myc-dependent dedifferentiation of Gata6<sup>+</sup> epidermal cells resembles reversal of terminal differentiation.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Bernabé-Rubio M,Ali S,Bhosale PG,Goss G,Mobasseri SA,Tapia-Rojo R,Zhu T,Hiratsuka T,Battilocchi M,Tomás IM,Ganier C,Garcia-Manyes S,Watt FM</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry to elucidate the molecular basis of epidermal dedifferentiation, which may be generally applicable to adult tissues.</div> <div itemprodp="datePublished">Sun Oct 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36674843"> <div itemprop="name">siRNA-Mediated MELK Knockdown Induces Accelerated Wound Healing with Increased Collagen Deposition.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Szymanski L,Lewicki S,Markiewicz T,Cierniak S,Tassan JP,Kubiak JZ</div> <div itemprop="description">14-0451-82 was used in Immunocytochemistry to evaluate the potential of MELK silencing to accelerate wound healing.</div> <div itemprodp="datePublished">Tue Jan 10 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36731891"> <div itemprop="name">BRCA1 deficiency in mature CD8<sup>+</sup> T lymphocytes impairs antitumor immunity.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Wu B,Qi L,Chiang HC,Pan H,Zhang X,Greenbaum A,Stark E,Wang LJ,Chen Y,Haddad BR,Clagett D,Isaacs C,Elledge R,Horvath A,Hu Y,Li R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36828819"> <div itemprop="name">CD11c<sup>+</sup> microglia promote white matter repair after ischemic stroke.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Jia J,Zheng L,Ye L,Chen J,Shu S,Xu S,Bao X,Xia S,Liu R,Xu Y,Zhang M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 24 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36592421"> <div itemprop="name">Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36846458"> <div itemprop="name">The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis.</div> </a> <div itemprop="about">PeerJ</div> <div itemprop="author">Li JL,Fu GQ,Wang YY,Bian MM,Xu YM,Zhang L,Chen YQ,Zhang N,Ding SQ,Wang R,Fang R,Tang J,Hu JG,Lü HZ</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry-immunofluorescence to study if M1 cells in injured spinal cords were mainly derived from MG rather than infiltrating Mø.</div> <div itemprodp="datePublished">Tue Feb 28 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33649045"> <div itemprop="name">Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions.</div> </a> <div itemprop="about">Gut</div> <div itemprop="author">Kolodkin-Gal D,Roitman L,Ovadya Y,Azazmeh N,Assouline B,Schlesinger Y,Kalifa R,Horwitz S,Khalatnik Y,Hochner-Ger A,Imam A,Demma JA,Winter E,Benyamini H,Elgavish S,Khatib AA,Meir K,Atlan K,Pikarsky E,Parnas O,Dor Y,Zamir G,Ben-Porath I,Krizhanovsky V</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35389887"> <div itemprop="name">The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Liang J,Huang G,Liu X,Taghavifar F,Liu N,Wang Y,Deng N,Yao C,Xie T,Kulur V,Dai K,Burman A,Rowan SC,Weigt SS,Belperio J,Stripp B,Parks WC,Jiang D,Noble PW</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35300585"> <div itemprop="name">Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages.</div> </a> <div itemprop="about">Cellular & molecular biology letters</div> <div itemprop="author">Gao T,Huang F,Wang W,Xie Y,Wang B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Mar 17 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35192678"> <div itemprop="name">BEX1 is a critical determinant of viral myocarditis.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Martens CR,Dorn LE,Kenney AD,Bansal SS,Yount JS,Accornero F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35563289"> <div itemprop="name">Trappc9 Deficiency Impairs the Plasticity of Stem Cells.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Usman M,Li Y,Ke Y,Chhetri G,Islam MA,Wang Z,Li X</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Thu Apr 28 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36066975"> <div itemprop="name">GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">de Souza CO,Paschoal VA,Sun X,Vishvanath L,Zhang Q,Shao M,Onodera T,Chen S,Joffin N,Bueno LM,Gupta RK,Oh DY</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36040807"> <div itemprop="name">Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Howard ZM,Gomatam CK,Rabolli CP,Lowe J,Piepho AB,Bansal SS,Accornero F,Rafael-Fortney JA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 10 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36703732"> <div itemprop="name">Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Wu H,Xie C,Wang R,Cheng J,Xu Q,Zhao H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 02 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35943203"> <div itemprop="name">Microglial angiotensin type 2 receptors mediate sex-specific expression of inflammatory cytokines independently of circulating estrogen.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Garrido-Gil P,Pedrosa MA,Garcia-Garrote M,Pequeño-Valtierra A,Rodríguez-Castro J,García-Souto D,Rodríguez-Pérez AI,Labandeira-Garcia JL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35897814"> <div itemprop="name">Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 26 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35027468"> <div itemprop="name">Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF.</div> </a> <div itemprop="about">Life science alliance</div> <div itemprop="author">Dichtl S,Sanin DE,Koss CK,Willenborg S,Petzold A,Tanzer MC,Dahl A,Kabat AM,Lindenthal L,Zeitler L,Satzinger S,Strasser A,Mann M,Roers A,Eming SA,El Kasmi KC,Pearce EJ,Murray PJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35393953"> <div itemprop="name">Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Linnerbauer M,Lößlein L,Vandrey O,Tsaktanis T,Beer A,Naumann UJ,Panier F,Beyer T,Nirschl L,Kuramatsu JB,Winkler J,Quintana FJ,Rothhammer V</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35074568"> <div itemprop="name">A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach.</div> </a> <div itemprop="about">Cellular and molecular gastroenterology and hepatology</div> <div itemprop="author">Douchi D,Yamamura A,Matsuo J,Lee JW,Nuttonmanit N,Melissa Lim YH,Suda K,Shimura M,Chen S,Pang S,Kohu K,Kaneko M,Kiyonari H,Kaneda A,Yoshida H,Taniuchi I,Osato M,Yang H,Unno M,Bok-Yan So J,Yeoh KG,Chuang LSH,Bae SC,Ito Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Mon Apr 18 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35020422"> <div itemprop="name">Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Kumar B,Adebayo AK,Prasad M,Capitano ML,Wang R,Bhat-Nakshatri P,Anjanappa M,Simpson E,Chen D,Liu Y,Schilder JM,Colter AB,Maguire C,Temm CJ,Sandusky G,Doud EH,Wijeratne AB,Mosley AL,Broxmeyer HE,Nakshatri H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 14 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34914635"> <div itemprop="name">The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Bechara R,Amatya N,Majumder S,Zhou C,Li Y,Liu Q,McGeachy MJ,Gaffen SL</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to show that Ccl2 mRNA upregulation in human stromal fibroblasts in response to IL-17 required the RNA-binding protein IGF-2 mRNA-binding protein 2 (IGF2BP2, IMP2), which is expressed almost exclusively in nonhematopoietic cells.</div> <div itemprodp="datePublished">Tue Feb 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34914635"> <div itemprop="name">The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Bechara R,Amatya N,Majumder S,Zhou C,Li Y,Liu Q,McGeachy MJ,Gaffen SL</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to show that Ccl2 mRNA upregulation in human stromal fibroblasts in response to IL-17 required the RNA-binding protein IGF-2 mRNA-binding protein 2 (IGF2BP2, IMP2), which is expressed almost exclusively in nonhematopoietic cells.</div> <div itemprodp="datePublished">Tue Feb 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34890843"> <div itemprop="name">Candida tropicalis Infection Modulates the Gut Microbiome and Confers Enhanced Susceptibility to Colitis in Mice.</div> </a> <div itemprop="about">Cellular and molecular gastroenterology and hepatology</div> <div itemprop="author">Di Martino L,De Salvo C,Buela KA,Hager C,Ghannoum M,Osme A,Buttò L,Bamias G,Pizarro TT,Cominelli F</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to determine the effects and mechanisms of action of Candida tropicalis on intestinal inflammation and injury in mouse models.</div> <div itemprodp="datePublished">Mon Apr 04 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34391772"> <div itemprop="name">Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.</div> </a> <div itemprop="about">Gastroenterology</div> <div itemprop="author">Douchi D,Yamamura A,Matsuo J,Melissa Lim YH,Nuttonmanit N,Shimura M,Suda K,Chen S,Pang S,Kohu K,Abe T,Shioi G,Kim G,Shabbir A,Srivastava S,Unno M,Bok-Yan So J,Teh M,Yeoh KG,Chuang LSH,Ito Y</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry to investigate whether pepsinogen C (PGC) transcript-expressing cells represent the cellular origin of metaplasia and cancer using a novel Pgc-specific CreERT2 recombinase mouse model.</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33388094"> <div itemprop="name">Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Guo Q,Zhao Y,Li J,Liu J,Yang X,Guo X,Kuang M,Xia H,Zhang Z,Cao L,Luo Y,Bao L,Wang X,Wei X,Deng W,Wang N,Chen L,Chen J,Zhu H,Gao R,Qin C,Wang X,You F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Feb 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34180951"> <div itemprop="name">Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34331779"> <div itemprop="name">Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.</div> </a> <div itemprop="about">Hepatology (Baltimore, Md.)</div> <div itemprop="author">Win S,Min RWM,Zhang J,Kanel G,Wanken B,Chen Y,Li M,Wang Y,Suzuki A,Aung FWM,Murray SF,Aghajan M,Than TA,Kaplowitz N</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33996416"> <div itemprop="name">Uptake and trafficking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model.</div> </a> <div itemprop="about">Acta pharmaceutica Sinica. B</div> <div itemprop="author">Lin Z,Xi L,Chen S,Tao J,Wang Y,Chen X,Li P,Wang Z,Zheng Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33555074"> <div itemprop="name">Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 15 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33929610"> <div itemprop="name">Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.</div> </a> <div itemprop="about">Basic research in cardiology</div> <div itemprop="author">Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33082517"> <div itemprop="name">Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Deng CL,Hu CB,Ling ST,Zhao N,Bao LH,Zhou F,Xiong YC,Chen T,Sui BD,Yu XR,Hu CH</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32694652"> <div itemprop="name">Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34327802"> <div itemprop="name">Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Funk KE,Arutyunov AD,Desai P,White JP,Soung AL,Rosen SF,Diamond MS,Klein RS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34309874"> <div itemprop="name">Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer.</div> </a> <div itemprop="about">The Journal of pathology</div> <div itemprop="author">Jiao L,Eickhoff R,Egners A,Jumpertz S,Roth J,Erdem M,Kroh A,Duimel H,López-Iglesias C,Caro P,Heij LR,Schmeding M,Meierhofer D,Neumann UP,Cramer T</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32157317"> <div itemprop="name">Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.</div> </a> <div itemprop="about">Cellular and molecular life sciences : CMLS</div> <div itemprop="author">Caputo T,Tran VDT,Bararpour N,Winkler C,Aguileta G,Trang KB,Giordano Attianese GMP,Wilson A,Thomas A,Pagni M,Guex N,Desvergne B,Gilardi F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34121311"> <div itemprop="name">RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.</div> </a> <div itemprop="about">EMBO reports</div> <div itemprop="author">Hu Y,Li X,Zhi X,Cong W,Huang B,Chen H,Wang Y,Li Y,Wang L,Fang C,Guo J,Liu Y,Cui J,Cao L,Weng W,Zhou Q,Wang S,Chen X,Su J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34174813"> <div itemprop="name">Macrophage polarization by MSC-derived CXCL12 determines tumor growth.</div> </a> <div itemprop="about">Cellular & molecular biology letters</div> <div itemprop="author">Babazadeh S,Nassiri SM,Siavashi V,Sahlabadi M,Hajinasrollah M,Zamani-Ahmadmahmudi M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jun 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33296111"> <div itemprop="name">The effects of postmortem delay on mouse and human microglia gene expression.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Heng Y,Dubbelaar ML,Marie SKN,Boddeke EWGM,Eggen BJL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33068332"> <div itemprop="name">Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Zhang X,Heng Y,Kooistra SM,van Weering HRJ,Brummer ML,Gerrits E,Wesseling EM,Brouwer N,Nijboer TW,Dubbelaar ML,Boddeke EWGM,Eggen BJL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33651379"> <div itemprop="name">Intercellular Interactions of an Adipogenic CXCL12-Expressing Stromal Cell Subset in Murine Bone Marrow.</div> </a> <div itemprop="about">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</div> <div itemprop="author">Matsushita Y,Chu AKY,Ono W,Welch JD,Ono N</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33651379"> <div itemprop="name">Intercellular Interactions of an Adipogenic CXCL12-Expressing Stromal Cell Subset in Murine Bone Marrow.</div> </a> <div itemprop="about">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</div> <div itemprop="author">Matsushita Y,Chu AKY,Ono W,Welch JD,Ono N</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34095141"> <div itemprop="name">Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Ying L,Zhang M,Ma X,Si Y,Li X,Su J,Yin J,Bao Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33510091"> <div itemprop="name">VX-765 reduces neuroinflammation after spinal cord injury in mice.</div> </a> <div itemprop="about">Neural regeneration research</div> <div itemprop="author">Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry to suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18.</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33438367"> <div itemprop="name">A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Wei DP,Li DD,Gu AQ,Ji WH,Yang Y,Peng JP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33590845"> <div itemprop="name">Maternal Cripto is required for proper uterine decidualization and peri-implantation uterine remodeling.</div> </a> <div itemprop="about">Biology of reproduction</div> <div itemprop="author">Shafiei S,Farah O,Dufort D</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry-immunofluorescence to investigate Cripto's role in female reproduction.</div> <div itemprodp="datePublished">Fri May 07 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33386611"> <div itemprop="name">Alterations of macrophage and neutrophil content in skeletal muscle of aged versus young mice.</div> </a> <div itemprop="about">Muscle & nerve</div> <div itemprop="author">Kawanishi N,Machida S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34671058"> <div itemprop="name">Differential activation of Ca<sup>2+</sup> influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.</div> </a> <div itemprop="about">NPJ Regenerative medicine</div> <div itemprop="author">Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Oct 20 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34671058"> <div itemprop="name">Differential activation of Ca<sup>2+</sup> influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.</div> </a> <div itemprop="about">NPJ Regenerative medicine</div> <div itemprop="author">Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Oct 20 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34108488"> <div itemprop="name">Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ribas-Latre A,Santos RB,Fekry B,Tamim YM,Shivshankar S,Mohamed AMT,Baumgartner C,Kwok C,Gebhardt C,Rivera A,Gao Z,Sun K,Heiker JT,Snyder BE,Kolonin MG,Eckel-Mahan KL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Wed Jun 09 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34103524"> <div itemprop="name">Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yang F,He Z,Duan H,Zhang D,Li J,Yang H,Dorsey JF,Zou W,Nabavizadeh SA,Bagley SJ,Abdullah K,Brem S,Zhang L,Xu X,Byrne KT,Vonderheide RH,Gong Y,Fan Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34071825"> <div itemprop="name">Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.</div> </a> <div itemprop="about">Biology</div> <div itemprop="author">Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (Frozen)</div> <div itemprodp="datePublished">Thu May 27 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34071825"> <div itemprop="name">Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.</div> </a> <div itemprop="about">Biology</div> <div itemprop="author">Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (Frozen)</div> <div itemprodp="datePublished">Thu May 27 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34812145"> <div itemprop="name">The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Roy A,Tomaz da Silva M,Bhat R,Bohnert KR,Iwawaki T,Kumar A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 23 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34006329"> <div itemprop="name">VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Borggrewe M,Kooistra SM,Wesseling EM,Gierschek FL,Brummer ML,Nowak EC,Medeiros-Furquim T,Otto TA,Lee SW,Noelle RJ,Eggen BJL,Laman JD</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Tue May 18 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34502391"> <div itemprop="name">The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Kübler M,Beck S,Peffenköver LL,Götz P,Ishikawa-Ankerhold H,Preissner KT,Fischer S,Lasch M,Deindl E</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Tue Aug 31 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34280086"> <div itemprop="name">Distinct skeletal stem cell types orchestrate long bone skeletogenesis.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Ambrosi TH,Sinha R,Steininger HM,Hoover MY,Murphy MP,Koepke LS,Wang Y,Lu WJ,Morri M,Neff NF,Weissman IL,Longaker MT,Chan CK</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34071589"> <div itemprop="name">C3 Deficiency Leads to Increased Angiogenesis and Elevated Pro-Angiogenic Leukocyte Recruitment in Ischemic Muscle Tissue.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Götz P,Braumandl A,Kübler M,Kumaraswami K,Ishikawa-Ankerhold H,Lasch M,Deindl E</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Fri May 28 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33916904"> <div itemprop="name">Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization.</div> </a> <div itemprop="about">Biomedicines</div> <div itemprop="author">Kübler M,Beck S,Fischer S,Götz P,Kumaraswami K,Ishikawa-Ankerhold H,Lasch M,Deindl E</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Apr 07 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34001904"> <div itemprop="name">Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry (PFA fixed)</div> <div itemprodp="datePublished">Mon May 17 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34446716"> <div itemprop="name">PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34583010"> <div itemprop="name">Cardiac-derived TGF-β1 confers resistance to diet-induced obesity through the regulation of adipocyte size and function.</div> </a> <div itemprop="about">Molecular metabolism</div> <div itemprop="author">Longenecker JZ,Petrosino JM,Martens CR,Hinger SA,Royer CJ,Dorn LE,Branch DA,Serrano J,Stanford KI,Kyriazis GA,Baskin KK,Accornero F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34131204"> <div itemprop="name">Determining the effect of aging, recovery time, and post-stroke memantine treatment on delayed thalamic gliosis after cortical infarct.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Kim GS,Stephenson JM,Al Mamun A,Wu T,Goss MG,Min JW,Li J,Liu F,Marrelli SP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 15 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33407600"> <div itemprop="name">Differential neurovirulence of Usutu virus lineages in mice and neuronal cells.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Clé M,Constant O,Barthelemy J,Desmetz C,Martin MF,Lapeyre L,Cadar D,Savini G,Teodori L,Monaco F,Schmidt-Chanasit J,Saiz JC,Gonzales G,Lecollinet S,Beck C,Gosselet F,Van de Perre P,Foulongne V,Salinas S,Simonin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Jan 06 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34513931"> <div itemprop="name">Transcriptional Network Analysis Reveals the Role of miR-223-5p During Diabetic Corneal Epithelial Regeneration.</div> </a> <div itemprop="about">Frontiers in molecular biosciences</div> <div itemprop="author">Zhang Y,Dou S,Qi X,Zhang Z,Qiao Y,Wang Y,Xie J,Jiang H,Zhang B,Zhou Q,Wang Q,Xie L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Thu Apr 13 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34712245"> <div itemprop="name">Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 10 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34923976"> <div itemprop="name">A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases.</div> </a> <div itemprop="about">Journal of nanobiotechnology</div> <div itemprop="author">Qiu N,Yang X,Zhang Y,Zhang J,Ji J,Zhang Y,Kong X,Xi Y,Liu D,Ye L,Zhai G</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Dec 19 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33562738"> <div itemprop="name">Early Adolescence Prefrontal Cortex Alterations in Female Rats Lacking Dopamine Transporter.</div> </a> <div itemprop="about">Biomedicines</div> <div itemprop="author">Illiano P,Leo D,Gainetdinov RR,Pardo M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Western Blot</div> <div itemprodp="datePublished">Fri Feb 05 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34154608"> <div itemprop="name">Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Chen KE,Lainez NM,Nair MG,Coss D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33490981"> <div itemprop="name">Quantitative <i>in vivo</i> assessment of amyloid-beta phagocytic capacity in an Alzheimer's disease mouse model.</div> </a> <div itemprop="about">STAR protocols</div> <div itemprop="author">Lau SF,Wu W,Seo H,Fu AKY,Ip NY</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33947861"> <div itemprop="name">Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Little DR,Lynch AM,Yan Y,Akiyama H,Kimura S,Chen J</div> <div itemprop="description">14-0451-85 was used in Immunohistochemistry (PFA fixed) to report that the cell-type-specific function of NKX2-1 is attributed to its differential chromatin binding that is acquired or retained during development in coordination with partner transcriptional factors.</div> <div itemprodp="datePublished">Tue May 04 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33974566"> <div itemprop="name">Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Falach R,Bar-On L,Lazar S,Kadar T,Mazor O,Aftalion M,Gur D,Evgy Y,Shifman O,Aminov T,Israeli O,Cohen-Gihon I,Zaide G,Gutman H,Vagima Y,Makdasi E,Stein D,Rosenfeld R,Alcalay R,Zahavy E,Levy H,Glinert I,Ben-Shmuel A,Israely T,Melamed S,Politi B,Achdout H,Yitzhaki S,Kronman C,Sabo T</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33420041"> <div itemprop="name">Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage.</div> </a> <div itemprop="about">NPJ vaccines</div> <div itemprop="author">Dubois V,Chatagnon J,Thiriard A,Bauderlique-Le Roy H,Debrie AS,Coutte L,Locht C</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 08 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33516262"> <div itemprop="name">The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jan 30 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34023385"> <div itemprop="name">NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Larson-Casey JL,Gu L,Kang J,Dhyani A,Carter AB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33795658"> <div itemprop="name">A decrease in NAD<sup>+</sup> contributes to the loss of osteoprogenitors and bone mass with aging.</div> </a> <div itemprop="about">NPJ aging and mechanisms of disease</div> <div itemprop="author">Kim HN,Ponte F,Warren A,Ring R,Iyer S,Han L,Almeida M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33557007"> <div itemprop="name">Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 04 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34446062"> <div itemprop="name">Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Abcouwer SF,Shanmugam S,Muthusamy A,Lin CM,Kong D,Hager H,Liu X,Antonetti DA</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry to suggest that iBRB restoration occurs as TJ complexes are reorganized and that resolution of inflammation and restoration of the iBRB following retinal IR injury are functionally linked.</div> <div itemprodp="datePublished">Thu Aug 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33632814"> <div itemprop="name">Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury.</div> </a> <div itemprop="about">eNeuro</div> <div itemprop="author">Pelisch N,Rosas Almanza J,Stehlik KE,Aperi BV,Kroner A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 18 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33778195"> <div itemprop="name">T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance.</div> </a> <div itemprop="about">Bioactive materials</div> <div itemprop="author">Yang X,Zhou F,Yuan P,Dou G,Liu X,Liu S,Wang X,Jin R,Dong Y,Zhou J,Lv Y,Deng Z,Liu S,Chen X,Han Y,Jin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34309509"> <div itemprop="name">Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Hallett SA,Matsushita Y,Ono W,Sakagami N,Mizuhashi K,Tokavanich N,Nagata M,Zhou A,Hirai T,Kronenberg HM,Ono N</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to conclude that slow-cycling chondrocytes are maintained in a Wnt-inhibitory environment within the resting zone, unraveling a novel mechanism regulating maintenance and differentiation of PTHrP+ skeletal stem cells of the postnatal growth plate.</div> <div itemprodp="datePublished">Mon Jul 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33921854"> <div itemprop="name">Placenta-Expanded Stromal Cell Therapy in a Rodent Model of Simulated Weightlessness.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Rubinstein L,Paul AM,Houseman C,Abegaz M,Tabares Ruiz S,O'Neil N,Kunis G,Ofir R,Cohen J,Ronca AE,Globus RK,Tahimic CGT</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Apr 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34084287"> <div itemprop="name">Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes.</div> </a> <div itemprop="about">Journal of extracellular vesicles</div> <div itemprop="author">Zheng C,Sui B,Zhang X,Hu J,Chen J,Liu J,Wu D,Ye Q,Xiang L,Qiu X,Liu S,Deng Z,Zhou J,Liu S,Shi S,Jin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33979628"> <div itemprop="name">Integrated OMICs unveil the bone-marrow microenvironment in human leukemia.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Passaro D,Garcia-Albornoz M,Diana G,Chakravarty P,Ariza-McNaughton L,Batsivari A,Borràs-Eroles C,Abarrategi A,Waclawiczek A,Ombrato L,Malanchi I,Gribben J,Bonnet D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 11 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33692790"> <div itemprop="name">Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33692790"> <div itemprop="name">Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33670906"> <div itemprop="name">Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Hillers-Ziemer LE,Williams AE,Janquart A,Grogan C,Thompson V,Sanchez A,Arendt LM</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to suggest that prior to tumor formation, obesity alters the lung microenvironment, creating niches conducive to metastatic growth.</div> <div itemprodp="datePublished">Sun Feb 28 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34145029"> <div itemprop="name">STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33618716"> <div itemprop="name">Systemic administration of β-glucan induces immune training in microglia.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Heng Y,Zhang X,Borggrewe M,van Weering HRJ,Brummer ML,Nijboer TW,Joosten LAB,Netea MG,Boddeke EWGM,Laman JD,Eggen BJL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 22 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32296175"> <div itemprop="name">Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Jiao H,Wachsmuth L,Kumari S,Schwarzer R,Lin J,Eren RO,Fisher A,Lane R,Young GR,Kassiotis G,Kaiser WJ,Pasparakis M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32296175"> <div itemprop="name">Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Jiao H,Wachsmuth L,Kumari S,Schwarzer R,Lin J,Eren RO,Fisher A,Lane R,Young GR,Kassiotis G,Kaiser WJ,Pasparakis M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32970988"> <div itemprop="name">Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Chikina AS,Nadalin F,Maurin M,San-Roman M,Thomas-Bonafos T,Li XV,Lameiras S,Baulande S,Henri S,Malissen B,Lacerda Mariano L,Barbazan J,Blander JM,Iliev ID,Matic Vignjevic D,Lennon-Duménil AM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32298651"> <div itemprop="name">Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Rao W,Wang S,Duleba M,Niroula S,Goller K,Xie J,Mahalingam R,Neupane R,Liew AA,Vincent M,Okuda K,O'Neal WK,Boucher RC,Dickey BF,Wechsler ME,Ibrahim O,Engelhardt JF,Mertens TCJ,Wang W,Jyothula SSK,Crum CP,Karmouty-Quintana H,Parekh KR,Metersky ML,McKeon FD,Xian W</div> <div itemprop="description">14-0451-85 was used in Immunohistochemistry (Paraffin) to inundate COPD lungs by three variant progenitors epigenetically committed to distinct metaplastic lesions.</div> <div itemprodp="datePublished">Thu May 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32367039"> <div itemprop="name">Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.</div> </a> <div itemprop="about">Cell research</div> <div itemprop="author">Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32673566"> <div itemprop="name">The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 18 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32673288"> <div itemprop="name">Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Jiang X,Tian W,Granucci EJ,Tu AB,Kim D,Dahms P,Pasupneti S,Peng G,Kim Y,Lim AH,Espinoza FH,Cribb M,Dixon JB,Rockson SG,Semenza GL,Nicolls MR</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to investigate the role of the Hif2a in lymphatic endothelial cells and its contribution to disease parthenogenesis when it is dysregulated.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31983527"> <div itemprop="name">Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease.</div> </a> <div itemprop="about">The Journal of allergy and clinical immunology</div> <div itemprop="author">Shears RK,Jacques LC,Naylor G,Miyashita L,Khandaker S,Lebre F,Lavelle EC,Grigg J,French N,Neill DR,Kadioglu A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31392723"> <div itemprop="name">Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects.</div> </a> <div itemprop="about">British journal of pharmacology</div> <div itemprop="author">De Cicco P,Ercolano G,Rubino V,Terrazzano G,Ruggiero G,Cirino G,Ianaro A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32098763"> <div itemprop="name">Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Gagniac L,Rusidzé M,Boudou F,Cagnet S,Adlanmerini M,Jeannot P,Gaide N,Giton F,Besson A,Weyl A,Gourdy P,Raymond-Letron I,Arnal JF,Brisken C,Lenfant F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33330583"> <div itemprop="name">Dysfunction of B Cell Leading to Failure of Immunoglobulin Response Is Ameliorated by Dietary Silk Peptide in 14-Month-Old C57BL/6 Mice.</div> </a> <div itemprop="about">Frontiers in nutrition</div> <div itemprop="author">Chei S,Oh HJ,Lee K,Jin H,Lee JY,Lee BY</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 18 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32012286"> <div itemprop="name">Sema3A and HIF1α co-overexpressed iPSC-MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Li J,Wang T,Li C,Wang Z,Wang P,Zheng L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33132837"> <div itemprop="name">Detection of Synaptic Proteins in Microglia by Flow Cytometry.</div> </a> <div itemprop="about">Frontiers in molecular neuroscience</div> <div itemprop="author">Brioschi S,d'Errico P,Amann LS,Janova H,Wojcik SM,Meyer-Luehmann M,Rajendran L,Wieghofer P,Paolicelli RC,Biber K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 03 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33763412"> <div itemprop="name">Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway <i>via</i> Acvr2b Suppression.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Feng B,Meng L,Luan L,Fang Z,Zhao P,Zhao G</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that activin receptor type IIB expression is inhibited by miR-132 from mesenchymal stem cells which attenuates ischemic neuronal injury.</div> <div itemprodp="datePublished">Fri Mar 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32017200"> <div itemprop="name">Extracellular adenosine enhances the ability of PMNs to kill Streptococcus pneumoniae by inhibiting IL-10 production.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Siwapornchai N,Lee JN,Tchalla EYI,Bhalla M,Yeoh JH,Roggensack SE,Leong JM,Bou Ghanem EN</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to explore why the antimicrobial efficacy of polymorphonuclear leukocytes declines over the course of infection.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32461220"> <div itemprop="name">Quantitative single-cell interactomes in normal and virus-infected mouse lungs.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Cain MP,Hernandez BJ,Chen J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Fri Jun 26 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32461220"> <div itemprop="name">Quantitative single-cell interactomes in normal and virus-infected mouse lungs.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Cain MP,Hernandez BJ,Chen J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Fri Jun 26 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32341057"> <div itemprop="name">Secreted Phospholipase A<sub>2</sub> Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.</div> <div itemprodp="datePublished">Mon Jun 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32963751"> <div itemprop="name">Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.</div> </a> <div itemprop="about">Therapeutic advances in chronic disease</div> <div itemprop="author">Zhang C,Gu X,Zhao G,Wang W,Shao J,Zhu J,Yuan T,Sun J,Nie D,Zhou Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Apr 17 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32715761"> <div itemprop="name">Virtual measurements of paracellular permeability and chronic inflammation via color coded pixel-wise T<sub>1</sub> mapping.</div> </a> <div itemprop="about">American journal of physiology. Renal physiology</div> <div itemprop="author">Singh N,Zabbarova I,Ikeda Y,Maranchie J,Chermansky C,Foley L,Hitchens TK,Yoshimura N,Kanai A,Kaufman J,Tyagi P</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry to assess whether quantitative T1 relaxometry can measure permeability, chronic inflammation and mural thickening of mouse bladder wall.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33091916"> <div itemprop="name">Tissue Inhibitor of Metalloproteinases-2 Mediates Kidney Injury during Sepsis.</div> </a> <div itemprop="about">Nephron</div> <div itemprop="author">Wen X,Zhang J,Wan X,Frank AA,Qu X,Kellum JA</div> <div itemprop="description">14-0451 was used in Immunohistochemistry-immunofluorescence to propose that urinary tissue inhibitor of metalloproteinases-2 mediates sepsis-associated acute kidney injury and appears to be a viable drug target.</div> <div itemprodp="datePublished">Tue Oct 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32186753"> <div itemprop="name">Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32198351"> <div itemprop="name">Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Fri Mar 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32198351"> <div itemprop="name">Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Fri Mar 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32324736"> <div itemprop="name">Study of Usutu virus neuropathogenicity in mice and human cellular models.</div> </a> <div itemprop="about">PLoS neglected tropical diseases</div> <div itemprop="author">Clé M,Barthelemy J,Desmetz C,Foulongne V,Lapeyre L,Bolloré K,Tuaillon E,Erkilic N,Kalatzis V,Lecollinet S,Beck C,Pirot N,Glasson Y,Gosselet F,Alvarez Martinez MT,Van de Perre P,Salinas S,Simonin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32753493"> <div itemprop="name">Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier.</div> </a> <div itemprop="about">mBio</div> <div itemprop="author">Clé M,Desmetz C,Barthelemy J,Martin MF,Constant O,Maarifi G,Foulongne V,Bolloré K,Glasson Y,De Bock F,Blaquiere M,Dehouck L,Pirot N,Tuaillon E,Nisole S,Najioullah F,Van de Perre P,Cabié A,Marchi N,Gosselet F,Simonin Y,Salinas S</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to suggest a complex interplay between ZIKV and the BBB, which may trigger local inflammation, leukocyte recruitment, and possible cerebral vasculature impairment.</div> <div itemprodp="datePublished">Tue Aug 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32753493"> <div itemprop="name">Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier.</div> </a> <div itemprop="about">mBio</div> <div itemprop="author">Clé M,Desmetz C,Barthelemy J,Martin MF,Constant O,Maarifi G,Foulongne V,Bolloré K,Glasson Y,De Bock F,Blaquiere M,Dehouck L,Pirot N,Tuaillon E,Nisole S,Najioullah F,Van de Perre P,Cabié A,Marchi N,Gosselet F,Simonin Y,Salinas S</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to suggest a complex interplay between ZIKV and the BBB, which may trigger local inflammation, leukocyte recruitment, and possible cerebral vasculature impairment.</div> <div itemprodp="datePublished">Tue Aug 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33219226"> <div itemprop="name">Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Okazaki K,Anzawa H,Liu Z,Ota N,Kitamura H,Onodera Y,Alam MM,Matsumaru D,Suzuki T,Katsuoka F,Tadaka S,Motoike I,Watanabe M,Hayasaka K,Sakurada A,Okada Y,Yamamoto M,Suzuki T,Kinoshita K,Sekine H,Motohashi H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 20 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33328477"> <div itemprop="name">Eosinophils improve cardiac function after myocardial infarction.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Liu J,Yang C,Liu T,Deng Z,Fang W,Zhang X,Li J,Huang Q,Liu C,Wang Y,Yang D,Sukhova GK,Lindholt JS,Diederichsen A,Rasmussen LM,Li D,Newton G,Luscinskas FW,Liu L,Libby P,Wang J,Guo J,Shi GP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 16 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32719317"> <div itemprop="name">TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Schöpp T,Zoch A,Berrens RV,Auchynnikava T,Kabayama Y,Vasiliauskaitė L,Rappsilber J,Allshire RC,O'Carroll D</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to show that TEX15 is an essential executor of mammalian PIWI-interacting RNA-directed DNA methylation.</div> <div itemprodp="datePublished">Mon Jul 27 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32861243"> <div itemprop="name">CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ</div> <div itemprop="description">14-0451-85 was used in Immunohistochemistry (Frozen) to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.</div> <div itemprodp="datePublished">Sat Aug 29 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32346042"> <div itemprop="name">Ly6c<sup>Lo</sup> non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32731354"> <div itemprop="name">Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Kuziel G,Thompson V,D'Amato JV,Arendt LM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32160239"> <div itemprop="name">Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Zhang M,Haughey M,Wang NY,Blease K,Kapoun AM,Couto S,Belka I,Hoey T,Groza M,Hartke J,Bennett B,Cain J,Gurney A,Benish B,Castiglioni P,Drew C,Lachowicz J,Carayannopoulos L,Nathan SD,Distler J,Brenner DA,Hariharan K,Cho H,Xie W</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry to provide an anti-fibrotic strategy for targeting the Wnt/β-catenin pathway through RSPO3 blockade and support that OMP-131R10 could be an important therapeutic agent for fibrosis.</div> <div itemprodp="datePublished">Tue Jul 07 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33012781"> <div itemprop="name">Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Yang L,Liu G,Li X,Xia Z,Wang Y,Lin W,Zhang W,Zhang W,Li X</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Oct 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32582193"> <div itemprop="name">Interferon Alpha Favors Macrophage Infection by Visceral <i>Leishmania</i> Species Through Upregulation of Sialoadhesin Expression.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Van Bockstal L,Bulté D,Van den Kerkhof M,Dirkx L,Mabille D,Hendrickx S,Delputte P,Maes L,Caljon G</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to assess the impact of type I IFN on macrophage infection with L. infantum and L. donovani and the implication of sialoadhesin as an IFN-inducible surface receptor.</div> <div itemprodp="datePublished">Fri Apr 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32385263"> <div itemprop="name">A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Kim JM,Yang YS,Park KH,Ge X,Xu R,Li N,Song M,Chun H,Bok S,Charles JF,Filhol-Cochet O,Boldyreff B,Dinter T,Yu PB,Kon N,Gu W,Takarada T,Greenblatt MB,Shim JH</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 08 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33263277"> <div itemprop="name">Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Kalinski AL,Yoon C,Huffman LD,Duncker PC,Kohen R,Passino R,Hafner H,Johnson C,Kawaguchi R,Carbajal KS,Jara JS,Hollis E,Geschwind DH,Segal BM,Giger RJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 02 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32750044"> <div itemprop="name">Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Markworth JF,Brown LA,Lim E,Floyd C,Larouche J,Castor-Macias JA,Sugg KB,Sarver DC,Macpherson PC,Davis C,Aguilar CA,Maddipati KR,Brooks SV</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 17 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33036616"> <div itemprop="name">Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Lowe PP,Morel C,Ambade A,Iracheta-Vellve A,Kwiatkowski E,Satishchandran A,Furi I,Cho Y,Gyongyosi B,Catalano D,Lefebvre E,Fischer L,Seyedkazemi S,Schafer DP,Szabo G</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 09 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32759495"> <div itemprop="name">Increased FGF-23 levels are linked to ineffective erythropoiesis and impaired bone mineralization in myelodysplastic syndromes.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Weidner H,Baschant U,Lademann F,Ledesma Colunga MG,Balaian E,Hofbauer C,Misof BM,Roschger P,Blouin S,Richards WG,Platzbecker U,Hofbauer LC,Rauner M</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to identify FGF-23 as a link between altered bone structure and ineffective erythropoiesis in MDS with the prospects of a targeted therapeutic intervention.</div> <div itemprodp="datePublished">Thu Aug 06 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33234602"> <div itemprop="name">Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Shigeta K,Matsui A,Kikuchi H,Klein S,Mamessier E,Chen IX,Aoki S,Kitahara S,Inoue K,Shigeta A,Hato T,Ramjiawan RR,Staiculescu D,Zopf D,Fiebig L,Hobbs GS,Quaas A,Dima S,Popescu I,Huang P,Munn LL,Cobbold M,Goyal L,Zhu AX,Jain RK,Duda DG</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to conclude that judicious regorafenib/anti-PD1 combination therapy can inhibit tumor growth and increase survival by normalizing tumor vasculature and increasing intratumoral CXCR3+CD8 T-cell infiltration through elevated CXCL10 expression in HCC cells.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33052221"> <div itemprop="name">Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Li Y,Ritzel RM,Khan N,Cao T,He J,Lei Z,Matyas JJ,Sabirzhanov B,Liu S,Li H,Stoica BA,Loane DJ,Faden AI,Wu J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32331524"> <div itemprop="name">Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Schröder N,Schaffrath A,Welter JA,Putzka T,Griep A,Ziegler P,Brandt E,Samer S,Heneka MT,Kaddatz H,Zhan J,Kipp E,Pufe T,Tauber SC,Kipp M,Brandenburg LO</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32814714"> <div itemprop="name">Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32724083"> <div itemprop="name">Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jandke A,Melandri D,Monin L,Ushakov DS,Laing AG,Vantourout P,East P,Nitta T,Narita T,Takayanagi H,Feederle R,Hayday A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32332858"> <div itemprop="name">Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.</div> </a> <div itemprop="about">Communications biology</div> <div itemprop="author">Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33062193"> <div itemprop="name">Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Dawicki W,Allen KJH,Garg R,Geoghegan EM,Berger MS,Ludwig DL,Dadachova E</div> <div itemprop="description">14-0451-85 was used in Flow Cytometry to investigate the effect of anti-CD45 radioimmunotherapy lymphodepletion on immune cell types and on tumor control in a model of adoptive cell therapy.</div> <div itemprodp="datePublished">Tue Sep 29 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32226299"> <div itemprop="name">PPARγ inhibition boosts efficacy of PD-L1 Checkpoint Blockade Immunotherapy against Murine Melanoma in a sexually dimorphic manner.</div> </a> <div itemprop="about">International journal of biological sciences</div> <div itemprop="author">Wu B,Sun X,Yuan B,Ge F,Gupta HB,Chiang HC,Li J,Hu Y,Curiel TJ,Li R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33424855"> <div itemprop="name">A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Wu CH,Gan CH,Li LH,Chang JC,Chen ST,Menon MP,Cheng SM,Yang SP,Ho CL,Chernikov OV,Lin CH,Lam Y,Hua KF</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33072626"> <div itemprop="name">CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.</div> </a> <div itemprop="about">Frontiers in cellular and infection microbiology</div> <div itemprop="author">Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 17 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32755539"> <div itemprop="name">Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Ricci B,Tycksen E,Celik H,Belle JI,Fontana F,Civitelli R,Faccio R</div> <div itemprop="description">14-0451-85 was used in Immunohistochemistry (Paraffin), Immunohistochemistry to find Osx transcript and Osx protein expression early during hematopoiesis, in subsets of hematopoietic stem cells and multipotent progenitor populations.</div> <div itemprodp="datePublished">Wed Aug 05 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32755539"> <div itemprop="name">Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Ricci B,Tycksen E,Celik H,Belle JI,Fontana F,Civitelli R,Faccio R</div> <div itemprop="description">14-0451-85 was used in Immunohistochemistry (Paraffin), Immunohistochemistry to find Osx transcript and Osx protein expression early during hematopoiesis, in subsets of hematopoietic stem cells and multipotent progenitor populations.</div> <div itemprodp="datePublished">Wed Aug 05 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33246491"> <div itemprop="name">Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.</div> </a> <div itemprop="about">Stem cell research & therapy</div> <div itemprop="author">Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 27 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32467752"> <div itemprop="name">Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.</div> </a> <div itemprop="about">Cell & bioscience</div> <div itemprop="author">Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 14 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31982571"> <div itemprop="name">Mesenchymal Stromal Cell-Derived Exosomes Contribute to Epithelial Regeneration in Experimental Inflammatory Bowel Disease.</div> </a> <div itemprop="about">Cellular and molecular gastroenterology and hepatology</div> <div itemprop="author">Barnhoorn MC,Plug L,Jonge ESMM,Molenkamp D,Bos E,Schoonderwoerd MJA,Corver WE,van der Meulen-de Jong AE,Verspaget HW,Hawinkels LJAC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon May 10 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31523027"> <div itemprop="name">Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Chen M,Reed RR,Lane AP</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to establish a mechanism whereby chronic rhinosinusitis inflammation causes a functional switch of neuroepithelial stem cells from regeneration to immune defense.</div> <div itemprodp="datePublished">Thu Oct 03 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31039135"> <div itemprop="name">Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.</div> <div itemprodp="datePublished">Tue Apr 30 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30988397"> <div itemprop="name">RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Krishna-Subramanian S,Singer S,Armaka M,Banales JM,Holzer K,Schirmacher P,Walczak H,Kollias G,Pasparakis M,Kondylis V</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to study the role of cell death on liver disease progression.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30783017"> <div itemprop="name">Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages.</div> </a> <div itemprop="about">EMBO reports</div> <div itemprop="author">Suh SH,Choe K,Hong SP,Jeong SH,Mäkinen T,Kim KS,Alitalo K,Surh CD,Koh GY,Song JH</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to explore whether and how the gut microbiota regulates the integrity of the lacteal, a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31648279"> <div itemprop="name">The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30246247"> <div itemprop="name">Distinct Tie2 tyrosine phosphorylation sites dictate phenotypic switching in endothelial progenitor cells.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Siavashi V,Nassiri SM,Rahbarghazi R,Mohseni Z,Sharifi AM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30612298"> <div itemprop="name">Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs.</div> </a> <div itemprop="about">Journal of cell communication and signaling</div> <div itemprop="author">Cervantes-Villagrana RD,Color-Aparicio VM,Reyes-Cruz G,Vázquez-Prado J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30578308"> <div itemprop="name">Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Percopo CM,Ma M,Brenner TA,Krumholz JO,Break TJ,Laky K,Rosenberg HF</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to examine the role of the pleiotropic cytokine IL-6 in acute infection with pneumonia virus of mice.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31354896"> <div itemprop="name">Antiallodynic Effects of Cannabinoid Receptor 2 (CB<sub>2</sub>R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.</div> </a> <div itemprop="about">Pain research & management</div> <div itemprop="author">Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Dec 16 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30998512"> <div itemprop="name">Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.</div> </a> <div itemprop="about">Anti-cancer drugs</div> <div itemprop="author">Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31631836"> <div itemprop="name">Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Walsh CM,Hill RZ,Schwendinger-Schreck J,Deguine J,Brock EC,Kucirek N,Rifi Z,Wei J,Gronert K,Brem RB,Barton GM,Bautista DM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 21 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31631836"> <div itemprop="name">Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Walsh CM,Hill RZ,Schwendinger-Schreck J,Deguine J,Brock EC,Kucirek N,Rifi Z,Wei J,Gronert K,Brem RB,Barton GM,Bautista DM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 21 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30704498"> <div itemprop="name">CSF1R antagonism limits local restimulation of antiviral CD8<sup>+</sup> T cells during viral encephalitis.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Funk KE,Klein RS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jan 31 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31287416"> <div itemprop="name">Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Lim J,Park H,Heisler J,Maculins T,Roose-Girma M,Xu M,Mckenzie B,van Lookeren Campagne M,Newton K,Murthy A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 09 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31253842"> <div itemprop="name">The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Huang J,Zhao L,Fan Y,Liao L,Ma PX,Xiao G,Chen D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 28 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31596239"> <div itemprop="name">Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Carpentier KS,Davenport BJ,Haist KC,McCarthy MK,May NA,Robison A,Ruckert C,Ebel GD,Morrison TE</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to reveal a previously unrecognized innate immune pathway that controls alphavirus viremia and dissemination in vertebrate hosts, ultimately influencing disease severity and likely transmission efficiency.</div> <div itemprodp="datePublished">Wed Oct 09 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31779710"> <div itemprop="name">MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Nov 28 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30711545"> <div itemprop="name">Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons.</div> </a> <div itemprop="about">Cellular and molecular gastroenterology and hepatology</div> <div itemprop="author">Cipriani G,Terhaar ML,Eisenman ST,Ji S,Linden DR,Wright AM,Sha L,Ordog T,Szurszewski JH,Gibbons SJ,Farrugia G</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 04 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31787973"> <div itemprop="name">Exposure to Cigarette Smoke Augments Post-ischemic Brain Injury and Inflammation via Mobilization of Neutrophils and Monocytes.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Li H,Li X,Gao S,Wang D,Gao X,Li Y,Wang X,Cui Z,Ma H,Liu Q,Li M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31462297"> <div itemprop="name">Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Gao W,Zhang X,Yang W,Dou D,Zhang H,Tang Y,Zhong W,Meng J,Bai Y,Liu Y,Yang L,Chen S,Liu H,Yang C,Sun T</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to investigate if a potential option for enhancing the efficacy of PD-1 inhibitors in clinical applications exists.</div> <div itemprodp="datePublished">Wed Aug 28 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31217348"> <div itemprop="name">Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Kono M,Maeda K,Stocton-Gavanescu I,Pan W,Umeda M,Katsuyama E,Burbano C,Orite SYK,Vukelic M,Tsokos MG,Yoshida N,Tsokos GC</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that CaMK4 binds to PKM2 and promotes its activity, which is requisite for Th1 and Th17 differentiation.</div> <div itemprodp="datePublished">Thu Jun 20 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31478830"> <div itemprop="name">FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Diaz Osterman CJ,Ozmadenci D,Kleinschmidt EG,Taylor KN,Barrie AM,Jiang S,Bean LM,Sulzmaier FJ,Jean C,Tancioni I,Anderson K,Uryu S,Cordasco EA,Li J,Chen XL,Fu G,Ojalill M,Rappu P,Heino J,Mark AM,Xu G,Fisch KM,Kolev VN,Weaver DT,Pachter JA,Győrffy B,McHale MT,Connolly DC,Molinolo A,Stupack DG,Schlaepfer DD</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 03 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31603905"> <div itemprop="name">Extracellular matrix turnover and inflammation in chemically-induced TMJ arthritis mouse models.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Morel M,Ruscitto A,Pylawka S,Reeve G,Embree MC</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to provide two methods of chemically induced TMJ inflammatory arthritis through a condyle explant model and intra-articular injection model that replicate findings seen in synovial fluid of human patients, which can be used for further studies delineating the mechanisms underlying TMJ pathology.</div> <div itemprodp="datePublished">Tue Mar 10 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31356165"> <div itemprop="name">IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.</div> </a> <div itemprop="about">ImmunoHorizons</div> <div itemprop="author">Poholek CH,Dulson SJ,Zajac AJ,Harrington LE</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to reveal a novel role for IL-21 in shaping innate lymphoid cell responses in the intestine and provide one mechanism by which effector CD4 T cells can influence innate immunity.</div> <div itemprodp="datePublished">Tue Jun 04 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30988300"> <div itemprop="name">PDGFRα<sup>+</sup> stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Joshi PA,Waterhouse PD,Kasaian K,Fang H,Gulyaeva O,Sul HS,Boutros PC,Khokha R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Apr 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30841538"> <div itemprop="name">Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 05 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29909986"> <div itemprop="name">Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29343440"> <div itemprop="name">Chanzyme TRPM7 Mediates the Ca<sup>2+</sup> Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 16 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29452935"> <div itemprop="name">E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 20 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29335648"> <div itemprop="name">Rapid chromatin repression by Aire provides precise control of immune tolerance.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Koh AS,Miller EL,Buenrostro JD,Moskowitz DM,Wang J,Greenleaf WJ,Chang HY,Crabtree GR</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that Brg1 and Aire fine-tune the expression of tissue-specific genes at levels that prevent toxicity yet promote immune tolerance.</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30290177"> <div itemprop="name">Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Verma M,Asakura Y,Murakonda BSR,Pengo T,Latroche C,Chazaud B,McLoon LK,Asakura A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 04 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29911993"> <div itemprop="name">Endothelial cells in the innate response to allergens and initiation of atopic asthma.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Asosingh K,Weiss K,Queisser K,Wanner N,Yin M,Aronica M,Erzurum S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Mon Jul 02 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29889098"> <div itemprop="name">Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Mande P,Zirak B,Ko WC,Taravati K,Bride KL,Brodeur TY,Deng A,Dresser K,Jiang Z,Ettinger R,Fitzgerald KA,Rosenblum MD,Harris JE,Marshak-Rothstein A</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to provide a relevant system for exploring the pathophysiology of cutaneous lupus erythematosus (CLE) as well as the negative regulatory role of TLR9.</div> <div itemprodp="datePublished">Mon Jul 02 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29664017"> <div itemprop="name">Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Fu X,Khalil H,Kanisicak O,Boyer JG,Vagnozzi RJ,Maliken BD,Sargent MA,Prasad V,Valiente-Alandi I,Blaxall BC,Molkentin JD</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to analyse and classify resident cardiac fibroblast dynamics during myocardial infarction injury and stable scar formation.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29759420"> <div itemprop="name">Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice.</div> </a> <div itemprop="about">Kidney international</div> <div itemprop="author">Cosgrove D,Dufek B,Meehan DT,Delimont D,Hartnett M,Samuelson G,Gratton MA,Phillips G,MacKenna DA,Bain G</div> <div itemprop="description">14-0451 was used in Immunohistochemistry-immunofluorescence to conclude that LOXL2 plays an important role in promoting both glomerular and interstitial pathogenesis associated with Alport syndrome in mice.</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29728652"> <div itemprop="name">Defective germline reprogramming rewires the spermatogonial transcriptome.</div> </a> <div itemprop="about">Nature structural & molecular biology</div> <div itemprop="author">Vasiliauskaitė L,Berrens RV,Ivanova I,Carrieri C,Reik W,Enright AJ,O'Carroll D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30463876"> <div itemprop="name">The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Zhang W,Li Q,Li D,Li J,Aki D,Liu YC</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.</div> <div itemprodp="datePublished">Mon Dec 03 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29891135"> <div itemprop="name">11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.</div> </a> <div itemprop="about">Journal of autoimmunity</div> <div itemprop="author">Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29678751"> <div itemprop="name">Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.</div> </a> <div itemprop="about">The Journal of allergy and clinical immunology</div> <div itemprop="author">Bloodworth MH,Rusznak M,Pfister CC,Zhang J,Bastarache L,Calvillo SA,Chappell JD,Boyd KL,Toki S,Newcomb DC,Stier MT,Zhou W,Goleniewska K,Moore ML,Hartert TV,Niswender KD,Peebles RS</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the effect of activating the GLP-1R signalling pathway on mice mimicking severe respiratory infection.</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29229786"> <div itemprop="name">Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Ziegler-Waldkirch S,d'Errico P,Sauer JF,Erny D,Savanthrapadian S,Loreth D,Katzmarski N,Blank T,Bartos M,Prinz M,Meyer-Luehmann M</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the impact and functional consequences of induced AB deposits on neurons in Alzheimer's disease.</div> <div itemprodp="datePublished">Wed Jan 17 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29221807"> <div itemprop="name">Ex Vivo Selection of Transduced Hematopoietic Stem Cells for Gene Therapy of β-Hemoglobinopathies.</div> </a> <div itemprop="about">Molecular therapy : the journal of the American Society of Gene Therapy</div> <div itemprop="author">Bhukhai K,de Dreuzy E,Giorgi M,Colomb C,Negre O,Denaro M,Gillet-Legrand B,Cheuzeville J,Paulard A,Trebeden-Negre H,Borwornpinyo S,Sii-Felice K,Maouche L,Down JD,Leboulch P,Payen E</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to propose a procedure for complete selection and preservation of tranduced hematopoietic stem cells for human clinical applications.</div> <div itemprodp="datePublished">Wed Feb 07 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29449644"> <div itemprop="name">Inhibition of the JNK/MAPK signaling pathway by myogenesis-associated miRNAs is required for skeletal muscle development.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Xie SJ,Li JH,Chen HF,Tan YY,Liu SR,Zhang Y,Xu H,Yang JH,Liu S,Zheng LL,Huang MB,Guo YH,Zhang Q,Zhou H,Qu LH</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29750788"> <div itemprop="name">Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.</div> </a> <div itemprop="about">PLoS biology</div> <div itemprop="author">Mensurado S,Rei M,Lança T,Ioannou M,Gonçalves-Sousa N,Kubo H,Malissen M,Papayannopoulos V,Serre K,Silva-Santos B</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the role of tumour-associated neutrophils in the regulation of γδ17 T-cell responses in the tumour microenvironment.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29725337"> <div itemprop="name">Humanized Mice Engrafted With Human HSC Only or HSC and Thymus Support Comparable HIV-1 Replication, Immunopathology, and Responses to ART and Immune Therapy.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Cheng L,Ma J,Li G,Su L</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to report that NRG-hu Thy/HSC and NRG-hu HSC mice support similar HIV-1 infection and similar HIV-1 immunopathology; and HIV-1 replication responds similarly to cART and IFNAR blockade therapies.</div> <div itemprodp="datePublished">Fri Jun 14 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29789715"> <div itemprop="name">Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Vorhagen S,Kleefisch D,Persa OD,Graband A,Schwickert A,Saynisch M,Leitges M,Niessen CM,Iden S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29921600"> <div itemprop="name">Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Casey AE,Sinha A,Singhania R,Livingstone J,Waterhouse P,Tharmapalan P,Cruickshank J,Shehata M,Drysdale E,Fang H,Kim H,Isserlin R,Bailey S,Medina T,Deblois G,Shiah YJ,Barsyte-Lovejoy D,Hofer S,Bader G,Lupien M,Arrowsmith C,Knapp S,De Carvalho D,Berman H,Boutros PC,Kislinger T,Khokha R</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the normal cell composition of the mammary epithelium by profiling primary cell epigenomes, transcriptomes and proteomes.</div> <div itemprodp="datePublished">Mon Aug 06 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30306644"> <div itemprop="name">VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Borggrewe M,Grit C,Den Dunnen WFA,Burm SM,Bajramovic JJ,Noelle RJ,Eggen BJL,Laman JD</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30335499"> <div itemprop="name">Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.</div> </a> <div itemprop="about">American journal of physiology. Lung cellular and molecular physiology</div> <div itemprop="author">Yee MC,Nichols HL,Polley D,Saifeddine M,Pal K,Lee K,Wilson EH,Daines MO,Hollenberg MD,Boitano S,DeFea KA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29437628"> <div itemprop="name">Prophylactic Antiheparanase Activity by PG545 Is Antiviral <i>In Vitro</i> and Protects against Ross River Virus Disease in Mice.</div> </a> <div itemprop="about">Antimicrobial agents and chemotherapy</div> <div itemprop="author">Supramaniam A,Liu X,Ferro V,Herrero LJ</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to describe both prophylactic and therapeutic treatment with PG545, a low-molecular-weight heparan sulfate mimetic, for arthritogenic alphaviral infection.</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29622551"> <div itemprop="name">Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Luo X,Yang S,Liang J,Zhai Y,Shen M,Sun J,Feng Y,Lu X,Zhu H,Wang F,Sun X</div> <div itemprop="description"></div> <div itemprodp="datePublished">Mon Apr 23 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29549177"> <div itemprop="name">CCR7 on CD4<sup>+</sup> T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Belikan P,Bühler U,Wolf C,Pramanik GK,Gollan R,Zipp F,Siffrin V</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to indicate a crucial role of CCR7 in neuroinflammation during the priming of autoimmune CD4+ T cells but not in the CNS.</div> <div itemprodp="datePublished">Sun Apr 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30158126"> <div itemprop="name">The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Hansell CAH,Fraser AR,Hayes AJ,Pingen M,Burt CL,Lee KM,Medina-Ruiz L,Brownlie D,Macleod MKL,Burgoyne P,Wilson GJ,Nibbs RJB,Graham GJ</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to determine the role of Ackr2 in metastasis.</div> <div itemprodp="datePublished">Mon Oct 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30010933"> <div itemprop="name">MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Gallot YS,Straughn AR,Bohnert KR,Xiong G,Hindi SM,Kumar A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29665133"> <div itemprop="name">Isolation of a unique hepatic stellate cell population expressing integrin α8 from embryonic mouse livers.</div> </a> <div itemprop="about">Developmental dynamics : an official publication of the American Association of Anatomists</div> <div itemprop="author">Ogawa T,Li Y,Lua I,Hartner A,Asahina K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30373214"> <div itemprop="name">Simultaneous Inhibition of MEK and Hh Signaling Reduces Pancreatic Cancer Metastasis.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Gu D,Lin H,Zhang X,Fan Q,Chen S,Shahda S,Liu Y,Sun J,Xie J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Fri Oct 26 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30111591"> <div itemprop="name">Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Koenis DS,Medzikovic L,Vos M,Beldman TJ,van Loenen PB,van Tiel CM,Hamers AAJ,Otermin Rubio I,de Waard V,de Vries CJM</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to provide evidence that a transgenic mouse model commonly used to study the biological function of Nur77 has several major drawbacks, while simultaneously identifying the importance of nongenomic Nur77 activity in the regulation of bone marrow homeostasis.</div> <div itemprodp="datePublished">Fri Sep 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30111591"> <div itemprop="name">Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Koenis DS,Medzikovic L,Vos M,Beldman TJ,van Loenen PB,van Tiel CM,Hamers AAJ,Otermin Rubio I,de Waard V,de Vries CJM</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to provide evidence that a transgenic mouse model commonly used to study the biological function of Nur77 has several major drawbacks, while simultaneously identifying the importance of nongenomic Nur77 activity in the regulation of bone marrow homeostasis.</div> <div itemprodp="datePublished">Fri Sep 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30365542"> <div itemprop="name">A patient derived xenograft model of cervical cancer and cervical dysplasia.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Larmour LI,Cousins FL,Teague JA,Deane JA,Jobling TW,Gargett CE</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Fri Mar 29 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30365542"> <div itemprop="name">A patient derived xenograft model of cervical cancer and cervical dysplasia.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Larmour LI,Cousins FL,Teague JA,Deane JA,Jobling TW,Gargett CE</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Fri Mar 29 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29500407"> <div itemprop="name">MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Clemente C,Rius C,Alonso-Herranz L,Martín-Alonso M,Pollán Á,Camafeita E,Martínez F,Mota RA,Núñez V,Rodríguez C,Seiki M,Martínez-González J,Andrés V,Ricote M,Arroyo AG</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 02 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33817078"> <div itemprop="name">mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.</div> </a> <div itemprop="about">Open life sciences</div> <div itemprop="author">Wang H,Xiao Y,Su L,Cui N,Liu D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jan 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29371665"> <div itemprop="name">Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Tosic M,Allen A,Willmann D,Lepper C,Kim J,Duteil D,Schüle R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jan 25 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30254630"> <div itemprop="name">Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Sep 25 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30181538"> <div itemprop="name">Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zwick RK,Rudolph MC,Shook BA,Holtrup B,Roth E,Lei V,Van Keymeulen A,Seewaldt V,Kwei S,Wysolmerski J,Rodeheffer MS,Horsley V</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 04 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30455690"> <div itemprop="name">ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 26 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29934585"> <div itemprop="name">Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 22 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29515165"> <div itemprop="name">Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 07 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30275453"> <div itemprop="name">Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Igarashi Y,Nawaz A,Kado T,Bilal M,Kuwano T,Yamamoto S,Sasahara M,Jiuxiang X,Inujima A,Koizumi K,Imura J,Shibahara N,Usui I,Fujisaka S,Tobe K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29429943"> <div itemprop="name">CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Wakabayashi T,Naito H,Suehiro JI,Lin Y,Kawaji H,Iba T,Kouno T,Ishikawa-Kato S,Furuno M,Takara K,Muramatsu F,Weizhen J,Kidoya H,Ishihara K,Hayashizaki Y,Nishida K,Yoder MC,Takakura N</div> <div itemprop="description">14-0451-82 was used in Flow cytometry/Cell sorting to show that tissue-resident VESCs display self-renewal capacity and that vascular regeneration potential exists in peripheral blood vessels.</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28218906"> <div itemprop="name">Differential cytokine contributions of perivascular haematopoietic stem cell niches.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28134623"> <div itemprop="name">A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28094767"> <div itemprop="name">Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Stein S,Lemos V,Xu P,Demagny H,Wang X,Ryu D,Jimenez V,Bosch F,Lüscher TF,Oosterveer MH,Schoonjans K</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to suggest that compromised SUMOylation of LRH-1 promotes the development of NAFLD under lipogenic conditions through regulation of OSBPL3.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28463232"> <div itemprop="name">Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Thanabalasuriar A,Surewaard BG,Willson ME,Neupane AS,Stover CK,Warrener P,Wilson G,Keller AE,Sellman BR,DiGiandomenico A,Kubes P</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to highlight the need to block multiple evasion and subversion mechanisms in tandem to kill P. aeruginosa.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27893460"> <div itemprop="name">TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Taylor RA,Chang CF,Goods BA,Hammond MD,Mac Grory B,Ai Y,Steinschneider AF,Renfroe SC,Askenase MH,McCullough LD,Kasner SE,Mullen MT,Hafler DA,Love JC,Sansing LH</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the specific responses of microglia following intracerebral haemorrhage with the aim of identifying pathways that may aid in recovery after brain injury.</div> <div itemprodp="datePublished">Tue Jan 03 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29084819"> <div itemprop="name">Mast cells acquire MHCII from dendritic cells during skin inflammation.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to identify an innate intercellular communication arming resident mast cells with key dendritic cell(DC) functions that might contribute to the acute defence potential during critical periods of migration-based DC absence.</div> <div itemprodp="datePublished">Mon Dec 04 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28566332"> <div itemprop="name">Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jul 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28716934"> <div itemprop="name">Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Tejada MA,Montilla-García A,Cronin SJ,Cikes D,Sánchez-Fernández C,González-Cano R,Ruiz-Cantero MC,Penninger JM,Vela JM,Baeyens JM,Cobos EJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28060378"> <div itemprop="name">CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Murphy PS,Wang J,Bhagwat SP,Munger JC,Janssen WJ,Wright TW,Elliott MR</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to show that, in RAW264.7 cells, ectopic expression of both A2a and CD73 was required for TNF suppression by apoptotic cells.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28401730"> <div itemprop="name">DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Kim HN,Chang J,Shao L,Han L,Iyer S,Manolagas SC,O'Brien CA,Jilka RL,Zhou D,Almeida M</div> <div itemprop="description"></div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29187227"> <div itemprop="name">Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity.</div> </a> <div itemprop="about">Breast cancer research : BCR</div> <div itemprop="author">Chamberlin T,D'Amato JV,Arendt LM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Nov 29 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28953978"> <div itemprop="name">Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.</div> <div itemprodp="datePublished">Fri Sep 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28273719"> <div itemprop="name">Depletion of microglia exacerbates postischemic inflammation and brain injury.</div> </a> <div itemprop="about">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</div> <div itemprop="author">Jin WN,Shi SX,Li Z,Li M,Wood K,Gonzales RJ,Liu Q</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27492949"> <div itemprop="name">An atypical role for the myeloid receptor Mincle in central nervous system injury.</div> </a> <div itemprop="about">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</div> <div itemprop="author">Arumugam TV,Manzanero S,Furtado M,Biggins PJ,Hsieh YH,Gelderblom M,MacDonald KP,Salimova E,Li YI,Korn O,Dewar D,Macrae IM,Ashman RB,Tang SC,Rosenthal NA,Ruitenberg MJ,Magnus T,Wells CA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28485322"> <div itemprop="name">Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8<sup>+</sup> T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.</div> </a> <div itemprop="about">Chinese medical journal</div> <div itemprop="author">Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 20 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27577867"> <div itemprop="name">Cornea lymphatics drive the CD8<sup>+</sup> T-cell response to herpes simplex virus-1.</div> </a> <div itemprop="about">Immunology and cell biology</div> <div itemprop="author">Gurung HR,Carr MM,Carr DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28921587"> <div itemprop="name">Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Krämer T,Grob T,Menzel L,Hirnet T,Griemert E,Radyushkin K,Thal SC,Methner A,Schaefer MKE</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Fri Dec 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27860312"> <div itemprop="name">Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Meng CY,Li ZY,Fang WN,Song ZH,Yang DD,Li DD,Yang Y,Peng JP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28513874"> <div itemprop="name">β3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche.</div> </a> <div itemprop="about">Journal of cellular biochemistry</div> <div itemprop="author">Vafaei R,Nassiri SM,Siavashi V</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28497488"> <div itemprop="name">The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model.</div> </a> <div itemprop="about">The Prostate</div> <div itemprop="author">Colinot DL,Garbuz T,Bosland MC,Wang L,Rice SE,Sullivan WJ,Arrizabalaga G,Jerde TJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29098081"> <div itemprop="name">Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease.</div> </a> <div itemprop="about">Journal of ophthalmology</div> <div itemprop="author">Fukui M,Ogawa Y,Mukai S,Kamoi M,Asato T,Kawakami Y,Tsubota K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Thu Mar 10 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28165063"> <div itemprop="name">Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Mon Feb 06 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28332979"> <div itemprop="name">The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Xiong G,Hindi SM,Mann AK,Gallot YS,Bohnert KR,Cavener DR,Whittemore SR,Kumar A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Mar 23 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29296535"> <div itemprop="name">Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Field CS,Hunn MK,Ferguson PM,Ruedl C,Ancelet LR,Hermans IF</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the effect of the checkpoint blockade on the efficacy of responses induced with a whole tumour-cell vaccine.</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29162901"> <div itemprop="name">microRNA-449a modulates medullary thymic epithelial cell differentiation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Chen P,Zhang H,Sun X,Hu Y,Jiang W,Liu Z,Liu S,Zhang X</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 21 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28570274"> <div itemprop="name">Tristetraprolin expression by keratinocytes controls local and systemic inflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Andrianne M,Assabban A,La C,Mogilenko D,Salle DS,Fleury S,Doumont G,Van Simaeys G,Nedospasov SA,Blackshear PJ,Dombrowicz D,Goriely S,Van Maele L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 02 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28405519"> <div itemprop="name">The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28594896"> <div itemprop="name">Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28814662"> <div itemprop="name">Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 17 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28494939"> <div itemprop="name">Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Redgrave RE,Tual-Chalot S,Davison BJ,Singh E,Hall D,Amirrasouli MM,Gilchrist D,Medvinsky A,Arthur HM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 09 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28696292"> <div itemprop="name">Acute inflammation regulates neuroregeneration through the NF-κB pathway in olfactory epithelium.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Chen M,Reed RR,Lane AP</div> <div itemprop="description">14-0451-82 was used in Immunohistochemistry-immunofluorescence to show that the repair of neuroepithelium after lesioning is accompanied by an acute, but self-limited, inflammatory process.</div> <div itemprodp="datePublished">Tue Jul 25 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27479084"> <div itemprop="name">An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27912060"> <div itemprop="name">The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Moroishi T,Hayashi T,Pan WW,Fujita Y,Holt MV,Qin J,Carson DA,Guan KL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27043409"> <div itemprop="name">Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27019226"> <div itemprop="name">Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Esterházy D,Loschko J,London M,Jove V,Oliveira TY,Mucida D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26656646"> <div itemprop="name">Oligodendrocyte death results in immune-mediated CNS demyelination.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26472817"> <div itemprop="name">Tissue-Specific Cell Cycle Indicator Reveals Unexpected Findings for Cardiac Myocyte Proliferation.</div> </a> <div itemprop="about">Circulation research</div> <div itemprop="author">Hirai M,Chen J,Evans SM</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to highlight advantages of a cardiac myocyte-specific cell cycle reporter for studies of cardiac myocyte cell cycle regulation.</div> <div itemprodp="datePublished">Fri Jan 08 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26277898"> <div itemprop="name">The breast tumor microenvironment alters the phenotype and function of natural killer cells.</div> </a> <div itemprop="about">Cellular & molecular immunology</div> <div itemprop="author">Krneta T,Gillgrass A,Chew M,Ashkar AA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27183387"> <div itemprop="name">Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Wang J,Mizui M,Zeng LF,Bronson R,Finnell M,Terhorst C,Kyttaris VC,Tsokos GC,Zhang ZY,Kontaridis MI</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to explore the effect of inhibiting SHP2 on T cell activation, ERK/MAPK signalling and the production of cytokines associated with organ damage in sufferers of systemic lupus erythematosus.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27594448"> <div itemprop="name">Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor.</div> </a> <div itemprop="about">Molecular cell</div> <div itemprop="author">Zhang B,Kwon OJ,Henry G,Malewska A,Wei X,Zhang L,Brinkley W,Zhang Y,Castro PD,Titus M,Chen R,Sayeeduddin M,Raj GV,Mauck R,Roehrborn C,Creighton CJ,Strand DW,Ittmann MM,Xin L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27165837"> <div itemprop="name">Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease.</div> </a> <div itemprop="about">Kidney international</div> <div itemprop="author">Dufek B,Meehan DT,Delimont D,Cheung L,Gratton MA,Phillips G,Song W,Liu S,Cosgrove D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26779981"> <div itemprop="name">Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification.</div> </a> <div itemprop="about">Annals of surgery</div> <div itemprop="author">Loder S,Agarwal S,Sorkin M,Breuler C,Li J,Peterson J,Gardenier J,Hsieh HH,Wang SC,Mehrara BJ,Levi B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26699479"> <div itemprop="name">Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Nishio M,Sugimachi K,Goto H,Wang J,Morikawa T,Miyachi Y,Takano Y,Hikasa H,Itoh T,Suzuki SO,Kurihara H,Aishima S,Leask A,Sasaki T,Nakano T,Nishina H,Nishikawa Y,Sekido Y,Nakao K,Shin-Ya K,Mimori K,Suzuki A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Tue Jan 05 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26876212"> <div itemprop="name">Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Du L,Chen X,Cao Y,Lu L,Zhang F,Bornstein S,Li Y,Owens P,Malkoski S,Said S,Jin F,Kulesz-Martin M,Gross N,Wang XJ,Lu SL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26129648"> <div itemprop="name">Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26242598"> <div itemprop="name">CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Arnold IC,Mathisen S,Schulthess J,Danne C,Hegazy AN,Powrie F</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the mechanism by which IL-23 produced by CD11c+ monocytes/macrophages promotes chronic Helicobacter hepaticus-induced intestinal inflammation.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26829557"> <div itemprop="name">IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Naujoks J,Tabeling C,Dill BD,Hoffmann C,Brown AS,Kunze M,Kempa S,Peter A,Mollenkopf HJ,Dorhoi A,Kershaw O,Gruber AD,Sander LE,Witzenrath M,Herold S,Nerlich A,Hocke AC,van Driel I,Suttorp N,Bedoui S,Hilbi H,Trost M,Opitz B</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to explore the overall role IFNs play in inducing substantial remodeling of bacterial vacuoles and in stimulating production of IRG1-derived itaconic acid which targets intravacuolar pathogens.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27926943"> <div itemprop="name">The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Thiel N,Keyser KA,Lemmermann NA,Oduro JD,Wagner K,Elsner C,Halenius A,Lenac Roviš T,Brinkmann MM,Jonjić S,Cicin-Sain L,Messerle M</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that the down-modulation of CD45 expression in MCMV-infected myeloid cells represents a novel pathway of virus-host interaction.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26694097"> <div itemprop="name">Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Mayer CE,Žuklys S,Zhanybekova S,Ohigashi I,Teh HY,Sansom SN,Shikama-Dorn N,Hafen K,Macaulay IC,Deadman ME,Ponting CP,Takahama Y,Holländer GA</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to reveal the spatio-temporal dynamics that control the growth of the thymic medulla.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27068890"> <div itemprop="name">Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Agarwal S,Loder SJ,Sorkin M,Li S,Shrestha S,Zhao B,Mishina Y,James AW,Levi B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27068890"> <div itemprop="name">Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Agarwal S,Loder SJ,Sorkin M,Li S,Shrestha S,Zhao B,Mishina Y,James AW,Levi B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27357149"> <div itemprop="name">Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Menendez CM,Jinkins JK,Carr DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27259856"> <div itemprop="name">Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Harakal J,Rival C,Qiao H,Tung KS</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to suggest that Tregs maintain physiological tolerance to clinically relevant gastric autoantigens, and Th2 responses can be a pathogenic mechanism in AIG.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26663781"> <div itemprop="name">Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Poczobutt JM,Nguyen TT,Hanson D,Li H,Sippel TR,Weiser-Evans MC,Gijon M,Murphy RC,Nemenoff RA</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to reveal an antitumorigenic role for 5-LO products in the microenvironment during lung cancer progression through T cell regulation.</div> <div itemprodp="datePublished">Fri Jan 15 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26756870"> <div itemprop="name">ECM-Dependence of Endothelial Progenitor Cell Features.</div> </a> <div itemprop="about">Journal of cellular biochemistry</div> <div itemprop="author">Siavashi V,Nassiri SM,Rahbarghazi R,Vafaei R,Sariri R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26572749"> <div itemprop="name">Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Hu Y,Zhang Y,Tian K,Xun C,Wang S,Lv D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26854397"> <div itemprop="name">A flow cytometric approach to analyzing mature and progenitor endothelial cells following traumatic brain injury.</div> </a> <div itemprop="about">Journal of neuroscience methods</div> <div itemprop="author">Assis-Nascimento P,Umland O,Cepero ML,Liebl DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27699223"> <div itemprop="name">Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Sato Y,Mii A,Hamazaki Y,Fujita H,Nakata H,Masuda K,Nishiyama S,Shibuya S,Haga H,Ogawa O,Shimizu A,Narumiya S,Kaisho T,Arita M,Yanagisawa M,Miyasaka M,Sharma K,Minato N,Kawamoto H,Yanagita M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Thu Jul 21 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27699223"> <div itemprop="name">Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Sato Y,Mii A,Hamazaki Y,Fujita H,Nakata H,Masuda K,Nishiyama S,Shibuya S,Haga H,Ogawa O,Shimizu A,Narumiya S,Kaisho T,Arita M,Yanagisawa M,Miyasaka M,Sharma K,Minato N,Kawamoto H,Yanagita M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Thu Jul 21 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28000790"> <div itemprop="name">A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 21 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27272654"> <div itemprop="name">Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 08 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27441847"> <div itemprop="name">A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Fransén-Pettersson N,Duarte N,Nilsson J,Lundholm M,Mayans S,Larefalk Å,Hannibal TD,Hansen L,Schmidt-Christensen A,Ivars F,Cardell S,Palmqvist R,Rozell B,Holmberg D</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to establish a new mouse model which spontaneously develops progressive inflammation and fibrosis in multiple organs.</div> <div itemprodp="datePublished">Mon Jul 24 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27220367"> <div itemprop="name">Brain trauma elicits non-canonical macrophage activation states.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Kim CC,Nakamura MC,Hsieh CL</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the novel activation states involved in the early macrophage response to traumatic brain injury.</div> <div itemprodp="datePublished">Tue May 24 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27538380"> <div itemprop="name">Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Klose R,Krzywinska E,Castells M,Gotthardt D,Putz EM,Kantari-Mimoun C,Chikdene N,Meinecke AK,Schrödter K,Helfrich I,Fandrey J,Sexl V,Stockmann C</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 19 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27195312"> <div itemprop="name">Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Li W,Liu L,Gomez A,Zhang J,Ramadan A,Zhang Q,Choi SW,Zhang P,Greenson JK,Liu C,Jiang D,Virts E,Kelich SL,Chu HW,Flynn R,Blazar BR,Hanenberg H,Hanash S,Paczesny S</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to discover an ICOS-stimulated, Th17-prone CD4(+)CD146(+)CCR5(+) T cell subset that may serve as an early gastrointestinal graft-versus-host-disease biomarker.</div> <div itemprodp="datePublished">Thu May 05 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26789017"> <div itemprop="name">Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.</div> </a> <div itemprop="about">PLoS genetics</div> <div itemprop="author">Satoh R,Kakugawa K,Yasuda T,Yoshida H,Sibilia M,Katsura Y,Levi B,Abramson J,Koseki Y,Koseki H,van Ewijk W,Hollander GA,Kawamoto H</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that Stat3-mediated signals via EGF-R determine medullary thymic epithelial cell cellularity and architectural organisation, and hence the size of the medulla.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27853644"> <div itemprop="name">Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Kleinpeter P,Fend L,Thioudellet C,Geist M,Sfrontato N,Koerper V,Fahrner C,Schmitt D,Gantzer M,Remy-Ziller C,Brandely R,Villeval D,Rittner K,Silvestre N,Erbs P,Zitvogel L,Quéméneur E,Préville X,Marchand JB</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to develop a method to vectorise a hamster monoclonal IgG against murine PD-1 in Western Reserve oncolytic vaccina virus.</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27659202"> <div itemprop="name">Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Xiong J,Zhou MF,Wang YD,Chen LP,Xu WF,Wang YD,Deng F,Liu SD</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Sep 23 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26601958"> <div itemprop="name">Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Wang B,Merillat SA,Vincent M,Huber AK,Basrur V,Mangelberger D,Zeng L,Elenitoba-Johnson K,Miller RA,Irani DN,Dlugosz AA,Schnell S,Scaglione KM,Paulson HL</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to establish that UBE2W is an important protein for early postnatal survival and the normal functioning of multiple organ systems.</div> <div itemprodp="datePublished">Fri Feb 05 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26789196"> <div itemprop="name">Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.</div> </a> <div itemprop="about">PLoS genetics</div> <div itemprop="author">Lomada D,Jain M,Bolner M,Reeh KA,Kang R,Reddy MC,DiGiovanni J,Richie ER</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that in addition to the NFkB pathway, Stat3-mediated signals play an essential role in regulating mTEC cellularity and medullary region homeostasis.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27335895"> <div itemprop="name">Preparation of Single Cell Suspensions from Mouse Aorta.</div> </a> <div itemprop="about">Bio-protocol</div> <div itemprop="author">Hu D,Yin C,Mohanta SK,Weber C,Habenicht AJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Jun 05 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27057467"> <div itemprop="name">Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26802627"> <div itemprop="name">Trogocytosis-associated cell to cell spread of intracellular bacterial pathogens.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Steele S,Radlinski L,Taft-Benz S,Brunton J,Kawula TH</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study trogocytosis-associated cell to cell spread of intracellular bacterial pathogens.</div> <div itemprodp="datePublished">Sat Jan 23 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27302484"> <div itemprop="name">Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27493002"> <div itemprop="name">LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Shi Y,Wu W,Chai Q,Li Q,Hou Y,Xia H,Ren B,Xu H,Guo X,Jin C,Lv M,Wang Z,Fu YX,Zhu M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 05 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26147083"> <div itemprop="name">Parent stem cells can serve as niches for their daughter cells.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Pardo-Saganta A,Tata PR,Law BM,Saez B,Chow RD,Prabhu M,Gridley T,Rajagopal J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Thu Jul 30 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25769612"> <div itemprop="name">CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Hickman HD,Reynoso GV,Ngudiankama BF,Cush SS,Gibbs J,Bennink JR,Yewdell JW</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate how CD8(+) T cells locate virus-infected cells within tissues, showing that the CXCR3 chemokine receptor enables migration for the destruction of virus-infected cells.</div> <div itemprodp="datePublished">Tue Mar 17 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25769612"> <div itemprop="name">CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Hickman HD,Reynoso GV,Ngudiankama BF,Cush SS,Gibbs J,Bennink JR,Yewdell JW</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate how CD8(+) T cells locate virus-infected cells within tissues, showing that the CXCR3 chemokine receptor enables migration for the destruction of virus-infected cells.</div> <div itemprodp="datePublished">Tue Mar 17 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26680207"> <div itemprop="name">Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26030851"> <div itemprop="name">Host microbiota constantly control maturation and function of microglia in the CNS.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Erny D,Hrabě de Angelis AL,Jaitin D,Wieghofer P,Staszewski O,David E,Keren-Shaul H,Mahlakoiv T,Jakobshagen K,Buch T,Schwierzeck V,Utermöhlen O,Chun E,Garrett WS,McCoy KD,Diefenbach A,Staeheli P,Stecher B,Amit I,Prinz M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25664855"> <div itemprop="name">Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Gori JL,Butler JM,Chan YY,Chandrasekaran D,Poulos MG,Ginsberg M,Nolan DJ,Elemento O,Wood BL,Adair JE,Rafii S,Kiem HP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 02 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25559893"> <div itemprop="name">Neutrophil-related factors as biomarkers in EAE and MS.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Rumble JM,Huber AK,Krishnamoorthy G,Srinivasan A,Giles DA,Zhang X,Wang L,Segal BM</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to provide evidence of neutrophil involvement in MS and the animal model EAE, and suggest neutrophil-related molecules as an alternative source of novel biomarkers and therapeutic targets in MS.</div> <div itemprodp="datePublished">Mon Jan 12 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25637383"> <div itemprop="name">Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Herbst S,Shah A,Mazon Moya M,Marzola V,Jensen B,Reed A,Birrell MA,Saijo S,Mostowy S,Shaunak S,Armstrong-James D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25142145"> <div itemprop="name">Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies.</div> </a> <div itemprop="about">Clinical cancer research : an official journal of the American Association for Cancer Research</div> <div itemprop="author">Dai M,Yip YY,Hellstrom I,Hellstrom KE</div> <div itemprop="description">14045182 was used in flow cytometry to test the efficacy of combining different monoclonal antibodies to treat cancer</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25568183"> <div itemprop="name">β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Hong Y,Manoharan I,Suryawanshi A,Majumdar T,Angus-Hill ML,Koni PA,Manicassamy B,Mellor AL,Munn DH,Manicassamy S</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to show that dendritic cells in the tumour microenvironment acquire the ability to metabolise vitamin A to produce retinoic acid, driving immune tolerance.</div> <div itemprodp="datePublished">Sun Feb 15 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25948589"> <div itemprop="name">Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Ruscetti M,Quach B,Dadashian EL,Mulholland DJ,Wu H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25858253"> <div itemprop="name">Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.</div> </a> <div itemprop="about">Cardiovascular research</div> <div itemprop="author">Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26645581"> <div itemprop="name">The transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation.</div> </a> <div itemprop="about">Science signaling</div> <div itemprop="author">Lau E,Feng Y,Claps G,Fukuda MN,Perlina A,Donn D,Jilaveanu L,Kluger H,Freeze HH,Ronai ZA</div> <div itemprop="description">14-0451 was used in Immunofluorescence to study how inhibiting PKCε or ATF2 or increasing protein fucosylation in tumor cells may improve clinical outcome in melanoma patients.</div> <div itemprodp="datePublished">Tue Dec 08 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26136374"> <div itemprop="name">Brahma is required for cell cycle arrest and late muscle gene expression during skeletal myogenesis.</div> </a> <div itemprop="about">EMBO reports</div> <div itemprop="author">Albini S,Coutinho Toto P,Dall'Agnese A,Malecova B,Cenciarelli C,Felsani A,Caruso M,Bultman SJ,Puri PL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26151762"> <div itemprop="name">The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Krah NM,De La O JP,Swift GH,Hoang CQ,Willet SG,Chen Pan F,Cash GM,Bronner MP,Wright CV,MacDonald RJ,Murtaugh LC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Tue Jul 07 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25100292"> <div itemprop="name">Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Visekruna A,Linnerz T,Martinic V,Vachharajani N,Hartmann S,Harb H,Joeris T,Pfefferle PI,Hofer MJ,Steinhoff U</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the role c-Rel plays in regulating innate lymphoid cells which induce anti-CD40-mediated innate colitis in mice.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25563499"> <div itemprop="name">IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Jung Y,Wen T,Mingler MK,Caldwell JM,Wang YH,Chaplin DD,Lee EH,Jang MH,Woo SY,Seoh JY,Miyasaka M,Rothenberg ME</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to show that eosinophils are required for mucosal production of IgA and development of Peyer's patches in the gut.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25492473"> <div itemprop="name">Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Jiang TT,Chaturvedi V,Ertelt JM,Xin L,Clark DR,Kinder JM,Way SS</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study susceptibility against Candida albicans fungal infectiong following eradication of commensal enteric bacteria, showing loss of commensal bacteria enhances antifungal immunity through robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, suggesting that enteric bacteria restrains activation of some immune components.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26347713"> <div itemprop="name">Transcriptional Pathways in cPGI2-Induced Adipocyte Progenitor Activation for Browning.</div> </a> <div itemprop="about">Frontiers in endocrinology</div> <div itemprop="author">Bayindir I,Babaeikelishomi R,Kocanova S,Sousa IS,Lerch S,Hardt O,Wild S,Bosio A,Bystricky K,Herzig S,Vegiopoulos A</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to develop models for the mechanistic investigation of progenitor-mediated beige/brite adipocyte differentiation.</div> <div itemprodp="datePublished">Tue Sep 08 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26026061"> <div itemprop="name">Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25710908"> <div itemprop="name">Ly6C(high) monocytes control cerebral toxoplasmosis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Biswas A,Bruder D,Wolf SA,Jeron A,Mack M,Heimesaat MM,Dunay IR</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to indicate the critical importance of recruited Ly6C monocytes upon cerebral toxoplasmosis.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25681334"> <div itemprop="name">Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Grinberg-Bleyer Y,Dainichi T,Oh H,Heise N,Klein U,Schmid RM,Hayden MS,Ghosh S</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to analyse the function of canonical NF-κB in the epidermis using CRE-mediated deletion of p65 and c-Rel in keratinocytes.</div> <div itemprodp="datePublished">Sun Mar 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25710911"> <div itemprop="name">Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Suryawanshi A,Manoharan I,Hong Y,Swafford D,Majumdar T,Taketo MM,Manicassamy B,Koni PA,Thangaraju M,Sun Z,Mellor AL,Munn DH,Manicassamy S</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the factors in the tissue microenvironment and signalling networks critical for programming dendritic cells to control chronic inflammation and promote tolerance, showing that Th1/Th17 responses are regulated by canonical Wnt signalling in dendritic cells and suppresses autoimmune neuroinflammation.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26071560"> <div itemprop="name">Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Evonuk KS,Baker BJ,Doyle RE,Moseley CE,Sestero CM,Johnston BP,De Sarno P,Tang A,Gembitsky I,Hewett SJ,Weaver CT,Raman C,DeSilva TM</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the link between inflammation and glutamate dysregulation in EAE, showing that inhibition of system Xc(-) transporter attenuates autoimmune inflammatory demyelination.</div> <div itemprodp="datePublished">Wed Jul 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26257993"> <div itemprop="name">Conditional immortalization of primary adipocyte precursor cells.</div> </a> <div itemprop="about">Adipocyte</div> <div itemprop="author">Church C,Brown M,Rodeheffer MS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 10 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26170908"> <div itemprop="name">Nonadherent culture method downregulates stem cell antigen-1 expression in mouse bone marrow mesenchymal stem cells.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Deng B,Deng W,Xiao P,Zeng K,Zhang S,Zhang H,Deng DY,Yang Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26617239"> <div itemprop="name">Endothelial Gata5 transcription factor regulates blood pressure.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 30 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26617239"> <div itemprop="name">Endothelial Gata5 transcription factor regulates blood pressure.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 30 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26107883"> <div itemprop="name">Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 28 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26408258"> <div itemprop="name">Doxil synergizes with cancer immunotherapies to enhance antitumor responses in syngeneic mouse models.</div> </a> <div itemprop="about">Neoplasia (New York, N.Y.)</div> <div itemprop="author">Rios-Doria J,Durham N,Wetzel L,Rothstein R,Chesebrough J,Holoweckyj N,Zhao W,Leow CC,Hollingsworth R</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the ability of doxorubicin and liposomal doxorubicin to enhance the antitumor response of different cancer immunotherapies in mouse models.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24380384"> <div itemprop="name">Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26424146"> <div itemprop="name">Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ.</div> </a> <div itemprop="about">BMC cancer</div> <div itemprop="author">Barham W,Chen L,Tikhomirov O,Onishko H,Gleaves L,Stricker TP,Blackwell TS,Yull FE</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to determine if activation of NF-κB in mammary epithelium could play a role in the formation of hyperplastic ductal lesions.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26252890"> <div itemprop="name">Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Mandl M,Drechsler M,Jansen Y,Neideck C,Noels H,Faussner A,Soehnlein O,Weber C,Döring Y</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate how continuous diphtheria toxin-induced pDC depletion in Apoe-/- BDCA2-DTR mice receiving a high-fat diet (HFD) for 4 weeks did not alter lesion size or composition.</div> <div itemprodp="datePublished">Sun May 08 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26387951"> <div itemprop="name">The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Hermann-Kleiter N,Klepsch V,Wallner S,Siegmund K,Klepsch S,Tuzlak S,Villunger A,Kaminski S,Pfeifhofer-Obermair C,Gruber T,Wolf D,Baier G</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 29 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25658639"> <div itemprop="name">Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Szulzewsky F,Pelz A,Feng X,Synowitz M,Markovic D,Langmann T,Holtman IR,Wang X,Eggen BJ,Boddeke HW,Hambardzumyan D,Wolf SA,Kettenmann H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25575242"> <div itemprop="name">CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.</div> <div itemprodp="datePublished">Fri Jan 09 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26344905"> <div itemprop="name">Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 13 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25693182"> <div itemprop="name">Cardiac telocytes and fibroblasts in primary culture: different morphologies and immunophenotypes.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Bei Y,Zhou Q,Fu S,Lv D,Chen P,Chen Y,Wang F,Xiao J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Nov 11 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26242630"> <div itemprop="name">Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity.</div> </a> <div itemprop="about">mBio</div> <div itemprop="author">Chastain EM,Getts DR,Miller SD</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to determine that disease-susceptible SJL/J mice lacked a unique innate immune population, which plays a role in early CNS virus clearance.</div> <div itemprodp="datePublished">Tue Aug 04 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26047815"> <div itemprop="name">Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes.</div> </a> <div itemprop="about">Cardiovascular diabetology</div> <div itemprop="author">Darrow AL,Shohet RV</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jun 06 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26241678"> <div itemprop="name">Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Brown EM,Wlodarska M,Willing BP,Vonaesch P,Han J,Reynolds LA,Arrieta MC,Uhrig M,Scholz R,Partida O,Borchers CH,Sansonetti PJ,Finlay BB</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to provide evidence indicating that both diet and microbes combine to contribute to the aetiology of environmental enteropathy.</div> <div itemprodp="datePublished">Tue Aug 04 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25857745"> <div itemprop="name">Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.</div> <div itemprodp="datePublished">Fri Apr 10 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25591994"> <div itemprop="name">Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung.</div> </a> <div itemprop="about">Respiratory research</div> <div itemprop="author">Sureshbabu A,Syed MA,Boddupalli CS,Dhodapkar MV,Homer RJ,Minoo P,Bhandari V</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the mechanisms responsible for TGFβ1-induced inflammatory signals leading to abnormal alveolarization, showing that it promotes pulmonary inflammation, apoptosis and mortality via TGFβR2.</div> <div itemprodp="datePublished">Fri Jan 16 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25807527"> <div itemprop="name">Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Fukuyama S,Katsura H,Zhao D,Ozawa M,Ando T,Shoemaker JE,Ishikawa I,Yamada S,Neumann G,Watanabe S,Kitano H,Kawaoka Y</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate influenza pathogenesis using influenza viruses expressing fluorescent proteins of different colours.</div> <div itemprodp="datePublished">Wed Mar 25 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25030167"> <div itemprop="name">Reprogramming human endothelial cells to haematopoietic cells requires vascular induction.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Sandler VM,Lis R,Liu Y,Kedem A,James D,Elemento O,Butler JM,Scandura JM,Rafii S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 17 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24412613"> <div itemprop="name">Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Campbell EL,Bruyninckx WJ,Kelly CJ,Glover LE,McNamee EN,Bowers BE,Bayless AJ,Scully M,Saeedi BJ,Golden-Mason L,Ehrentraut SF,Curtis VF,Burgess A,Garvey JF,Sorensen A,Nemenoff R,Jedlicka P,Taylor CT,Kominsky DJ,Colgan SP</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate whether transmigrating neutrophils influence the transcriptional profile of the surrounding mucosa.</div> <div itemprodp="datePublished">Thu Jan 16 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24657994"> <div itemprop="name">CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.</div> </a> <div itemprop="about">Circulation</div> <div itemprop="author">Laroumanie F,Douin-Echinard V,Pozzo J,Lairez O,Tortosa F,Vinel C,Delage C,Calise D,Dutaur M,Parini A,Pizzinat N</div> <div itemprop="description">14-0451 was used in Immunohistochemistry-immunofluorescence to investigate the involvement of T cells in the progression to heart failure using a transverse aortic constriction (TAC) model.</div> <div itemprodp="datePublished">Tue May 27 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24633226"> <div itemprop="name">Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25037571"> <div itemprop="name">Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation.</div> </a> <div itemprop="about">Circulation research</div> <div itemprop="author">Ali SR,Ranjbarvaziri S,Talkhabi M,Zhao P,Subat A,Hojjat A,Kamran P,Müller AM,Volz KS,Tang Z,Red-Horse K,Ardehali R</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the developmental origins of cardiac fibroblasts and characterise their corresponding phenotypes, to aid in determining the proliferation rates of each developmental subset.</div> <div itemprodp="datePublished">Fri Sep 12 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25037571"> <div itemprop="name">Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation.</div> </a> <div itemprop="about">Circulation research</div> <div itemprop="author">Ali SR,Ranjbarvaziri S,Talkhabi M,Zhao P,Subat A,Hojjat A,Kamran P,Müller AM,Volz KS,Tang Z,Red-Horse K,Ardehali R</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the developmental origins of cardiac fibroblasts and characterise their corresponding phenotypes, to aid in determining the proliferation rates of each developmental subset.</div> <div itemprodp="datePublished">Fri Sep 12 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24937432"> <div itemprop="name">Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Moore-Morris T,Guimarães-Camboa N,Banerjee I,Zambon AC,Kisseleva T,Velayoudon A,Stallcup WB,Gu Y,Dalton ND,Cedenilla M,Gomez-Amaro R,Zhou B,Brenner DA,Peterson KL,Chen J,Evans SM</div> <div itemprop="description">14-0451 was used in Immunofluorescence to study the the origins of cardiac fibroblasts during development and in fibrosis.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25332287"> <div itemprop="name">Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Velardi E,Tsai JJ,Holland AM,Wertheimer T,Yu VW,Zakrzewski JL,Tuckett AZ,Singer NV,West ML,Smith OM,Young LF,Kreines FM,Levy ER,Boyd RL,Scadden DT,Dudakov JA,van den Brink MR</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to reveal a novel mechanism underlying improved thymic regeneration upon sex steroid ablation.</div> <div itemprodp="datePublished">Mon Nov 17 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24399752"> <div itemprop="name">Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Basler M,Mundt S,Muchamuel T,Moll C,Jiang J,Groettrup M,Kirk CJ</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the therapeutic efficacy of an immunoproteasome inhibitor, ONX 0914, in two different mouse models of multiple sclerosis.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24968718"> <div itemprop="name">Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Diana J,Lehuen A</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to determine the cellular and molecular mechanisms leading to the recruitment of neutrophils in the pancreatic islets of non-obese diabetic mice.</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24583793"> <div itemprop="name">Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor.</div> </a> <div itemprop="about">Clinical cancer research : an official journal of the American Association for Cancer Research</div> <div itemprop="author">Kim TS,Cavnar MJ,Cohen NA,Sorenson EC,Greer JB,Seifert AM,Crawley MH,Green BL,Popow R,Pillarsetty N,Veach DR,Ku AT,Rossi F,Besmer P,Antonescu CR,Zeng S,Dematteo RP</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to explore the ability of PLX3397 to deplete tumour-associated macrophages in gastrointestinal stromal cancer models.</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25074920"> <div itemprop="name">p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Senturk S,Yao Z,Camiolo M,Stiles B,Rathod T,Walsh AM,Nemajerova A,Lazzara MJ,Altorki NK,Krainer A,Moll UM,Lowe SW,Cartegni L,Sordella R</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to describe a unique mode of p53 regulation involving alternative splicing of the TP53 gene.</div> <div itemprodp="datePublished">Tue Aug 12 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25074920"> <div itemprop="name">p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Senturk S,Yao Z,Camiolo M,Stiles B,Rathod T,Walsh AM,Nemajerova A,Lazzara MJ,Altorki NK,Krainer A,Moll UM,Lowe SW,Cartegni L,Sordella R</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to describe a unique mode of p53 regulation involving alternative splicing of the TP53 gene.</div> <div itemprodp="datePublished">Tue Aug 12 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24624965"> <div itemprop="name">Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells.</div> </a> <div itemprop="about">Journal of biomedical science</div> <div itemprop="author">Cheng CC,Lee YH,Lin SP,Huangfu WC,Liu IH</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Mar 13 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24733756"> <div itemprop="name">Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Cekanaviciute E,Fathali N,Doyle KP,Williams AM,Han J,Buckwalter MS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24766345"> <div itemprop="name">Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice.</div> </a> <div itemprop="about">Antioxidants & redox signaling</div> <div itemprop="author">Kim MJ,Ryu JC,Kwon Y,Lee S,Bae YS,Yoon JH,Ryu JH</div> <div itemprop="description">14-0451 was used in Functional assays to investigate the molecular mechanisms of ROS production in type II alveolar epithelial cells, showing that dual oxidase 2 is essential for hyperoxia-induced acute lung injury.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24222670"> <div itemprop="name">Paradoxical resistance to high-fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor-overexpressing mice.</div> </a> <div itemprop="about">American journal of physiology. Endocrinology and metabolism</div> <div itemprop="author">Kuhn E,Bourgeois C,Keo V,Viengchareun S,Muscat A,Meduri G,Le Menuet D,Fève B,Lombès M</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the in vivo metabolic impact of the mineralocorticoid receptor (MR), showing that overexpression of MR leads to resistance to high-fat diet-induced obesity and altered macrophage polarisation.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24446236"> <div itemprop="name">Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Suga H,Rennert RC,Rodrigues M,Sorkin M,Glotzbach JP,Januszyk M,Fujiwara T,Longaker MT,Gurtner GC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24446236"> <div itemprop="name">Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Suga H,Rennert RC,Rodrigues M,Sorkin M,Glotzbach JP,Januszyk M,Fujiwara T,Longaker MT,Gurtner GC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25451154"> <div itemprop="name">Bone marrow mesenchymal stem cells provide an antibiotic-protective niche for persistent viable Mycobacterium tuberculosis that survive antibiotic treatment.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Beamer G,Major S,Das B,Campos-Neto A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Dec 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24913979"> <div itemprop="name">Cytokine-regulated neutrophil recruitment is required for brain but not spinal cord inflammation during experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Simmons SB,Liggitt D,Goverman JM</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the pathways that determine whether damage occurs in the brain or spinal cord in multiple sclerosis, showing that cytokine-regulated neutrophil recruitment is required for brain but not spinal cord.</div> <div itemprodp="datePublished">Tue Jul 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25274531"> <div itemprop="name">Regulatory T cells dynamically regulate selectin ligand function during multiple challenge contact hypersensitivity.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Abeynaike LD,Deane JA,Westhorpe CL,Chow Z,Alikhan MA,Kitching AR,Issekutz A,Hickey MJ</div> <div itemprop="description">14-0451 was used in Immunohistochemistry on frozen tissues to study the rolling of endogenous regulatory T cells in dermal postcapillary venules.</div> <div itemprodp="datePublished">Sat Nov 15 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24807637"> <div itemprop="name">IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.</div> </a> <div itemprop="about">Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology</div> <div itemprop="author">Lajoie S,Lewkowich I,Herman NS,Sproles A,Pesce JT,Wynn TA,Grusby MJ,Hamid Q,Wills-Karp M</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to suggest that IL-21 plays an important role in the allergic diathesis by enhancing Th2 cytokine production through multiple mechanisms.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24777188"> <div itemprop="name">Negative selection by apoptosis enriches progenitors in naïve and expanded human umbilical cord blood grafts.</div> </a> <div itemprop="about">Bone marrow transplantation</div> <div itemprop="author">Mizrahi K,Ash S,Peled T,Yaniv I,Stein J,Askenasy N</div> <div itemprop="description">14-0451-82 was used in Flow cytometry/Cell sorting to evaluate the influence of TNF-α and Fas-ligand on viability and function of umbilical cord blood cells.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24566711"> <div itemprop="name">Apoptotic signaling through Fas and TNF receptors ameliorates GVHD in mobilized peripheral blood grafts.</div> </a> <div itemprop="about">Bone marrow transplantation</div> <div itemprop="author">Mizrahi K,Yaniv I,Ash S,Stein J,Askenasy N</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to assess the susceptibility of mobilised peripheral blood cells to spontaneous and receptor-induced apoptosis as a possible approach to GVHD prophylaxis.</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24683512"> <div itemprop="name">Fgf2 improves functional recovery-decreasing gliosis and increasing radial glia and neural progenitor cells after spinal cord injury.</div> </a> <div itemprop="about">Brain and behavior</div> <div itemprop="author">Goldshmit Y,Frisca F,Pinto AR,Pébay A,Tang JK,Siegel AL,Kaslin J,Currie PD</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that early pharmacological intervention with Fgf2 following spinal cord injury is neuroprotective.</div> <div itemprodp="datePublished">Sat Mar 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24852660"> <div itemprop="name">Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells.</div> </a> <div itemprop="about">Experimental hematology</div> <div itemprop="author">Duong KL,Das S,Yu S,Barr JY,Jena S,Kim E,Zavazava N,Colgan JD,Xue HH,Levasseur DN</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24829059"> <div itemprop="name">KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice.</div> </a> <div itemprop="about">Autoimmunity</div> <div itemprop="author">Koga T,Mizui M,Yoshida N,Otomo K,Lieberman LA,Crispín JC,Tsokos GC</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the mechanism of CaMK4 on Treg cells in systemic lupus erythematosus, showing that inhibition promotes generation and function of Foxp3+ Tregs.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25238161"> <div itemprop="name">No beneficial effect of general and specific anti-inflammatory therapies on aortic dilatation in Marfan mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Franken R,Hibender S,den Hartog AW,Radonic T,de Vries CJ,Zwinderman AH,Groenink M,Mulder BJ,de Waard V</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to examine the efficacy of anti-inflammatory therapies in attenuating aortic root dilation in Marfan syndrome and compared effects to the main preventative agent, losartan.</div> <div itemprodp="datePublished">Tue Jun 16 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24401681"> <div itemprop="name">A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Yang M,Rainone A,Shi XQ,Fournier S,Zhang J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 08 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25198549"> <div itemprop="name">Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu May 28 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25445147"> <div itemprop="name">Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Hari A,Zhang Y,Tu Z,Detampel P,Stenner M,Ganguly A,Shi Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 02 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25054064"> <div itemprop="name">The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Li M,Bolduc AR,Hoda MN,Gamble DN,Dolisca SB,Bolduc AK,Hoang K,Ashley C,McCall D,Rojiani AM,Maria BL,Rixe O,MacDonald TJ,Heeger PS,Mellor AL,Munn DH,Johnson TS</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to investigate whether Indoleamine 2,3-dioxygenase protects glioblastoma from the full effects of chemo-radiation therapy by preventing vascular activation and complement-dependent tumour destruction.</div> <div itemprodp="datePublished">Wed Jul 23 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24366868"> <div itemprop="name">The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 14 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25347065"> <div itemprop="name">CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.</div> <div itemprodp="datePublished">Mon Oct 27 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24991401"> <div itemprop="name">Intravenous immunoglobulin (IVIg) provides protection against endothelial cell dysfunction and death in ischemic stroke.</div> </a> <div itemprop="about">Experimental & translational stroke medicine</div> <div itemprop="author">Widiapradja A,Santro T,Basta M,Sobey CG,Manzanero S,Arumugam TV</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study how intravenous immunoglobulin protects endothelial cells from ischaemic insult, supporting its use as a pharmacological intervention for stroke therapy.</div> <div itemprodp="datePublished">Thu Jul 03 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23671208"> <div itemprop="name">Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis.</div> </a> <div itemprop="about">Circulation</div> <div itemprop="author">Kania G,Siegert S,Behnke S,Prados-Rosales R,Casadevall A,Lüscher TF,Luther SA,Kopf M,Eriksson U,Blyszczuk P</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate how activation of innate pattern-recognition receptors is critical not only for disease induction but also for counterregulatory mechanisms, protecting the heart from exaggerated autoimmunity.</div> <div itemprodp="datePublished">Tue Jun 11 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23414756"> <div itemprop="name">Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Hickman HD,Reynoso GV,Ngudiankama BF,Rubin EJ,Magadán JG,Cush SS,Gibbs J,Molon B,Bronte V,Bennink JR,Yewdell JW</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to explore the spatiotemporal organization between antiviral immune cells and vaccinia virus-infected murine cells.</div> <div itemprodp="datePublished">Wed Feb 13 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23624557"> <div itemprop="name">Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Taketomi Y,Ueno N,Kojima T,Sato H,Murase R,Yamamoto K,Tanaka S,Sakanaka M,Nakamura M,Nishito Y,Kawana M,Kambe N,Ikeda K,Taguchi R,Nakamizo S,Kabashima K,Gelb MH,Arita M,Yokomizo T,Nakamura M,Watanabe K,Hirai H,Nakamura M,Okayama Y,Ra C,Aritake K,Urade Y,Morimoto K,Sugimoto Y,Shimizu T,Narumiya S,Hara S,Murakami M</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to report that PLA2G3, a mammalian homolog of anaphylactic bee venom phospholipase A2, regulates mast cell maturation via a lipid mediator circuit.</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23434824"> <div itemprop="name">Nrf2 regulates haematopoietic stem cell function.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23327924"> <div itemprop="name">Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.</div> <div itemprodp="datePublished">Thu Apr 25 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23748430"> <div itemprop="name">A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling.</div> </a> <div itemprop="about">Circulation research</div> <div itemprop="author">Chen YC,Bui AV,Diesch J,Manasseh R,Hausding C,Rivera J,Haviv I,Agrotis A,Htun NM,Jowett J,Hagemeyer CE,Hannan RD,Bobik A,Peter K</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to develop and test therapeutic strategies aimed at preventing plaque rupture.</div> <div itemprodp="datePublished">Fri Jul 19 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23348743"> <div itemprop="name">Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Gandhirajan RK,Meng S,Chandramoorthy HC,Mallilankaraman K,Mancarella S,Gao H,Razmpour R,Yang XF,Houser SR,Chen J,Koch WJ,Wang H,Soboloff J,Gill DL,Madesh M</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to elucidate the molecular mechanisms behind the development of LPS-induced acute lung injury.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23615497"> <div itemprop="name">Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions.</div> </a> <div itemprop="about">Kidney international</div> <div itemprop="author">Hu J,Zhang L,Wang N,Ding R,Cui S,Zhu F,Xie Y,Sun X,Wu D,Hong Q,Li Q,Shi S,Liu X,Chen X</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study how mesenchymal stem cells ameliorate ischemic acute kidney injury by inducing regulatory T cells through interactions with splenocytes.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23319699"> <div itemprop="name">HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.</div> <div itemprodp="datePublished">Mon Feb 11 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23704211"> <div itemprop="name">Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Baird JR,Fox BA,Sanders KL,Lizotte PH,Cubillos-Ruiz JR,Scarlett UK,Rutkowski MR,Conejo-Garcia JR,Fiering S,Bzik DJ</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to establish that cps preferentially invades tumour-associated antigen-presenting cells and restores their ability to trigger potent anti-tumour CD8(+) T-cell responses.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23650399"> <div itemprop="name">Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Coombes JL,Charsar BA,Han SJ,Halkias J,Chan SW,Koshy AA,Striepen B,Robey EA</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to explore the parasite-host interaction between Toxoplasma gondii and intestinal immune cells.</div> <div itemprodp="datePublished">Tue May 21 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22990625"> <div itemprop="name">Colonic patch and colonic SILT development are independent and differentially regulated events.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Baptista AP,Olivier BJ,Goverse G,Greuter M,Knippenberg M,Kusser K,Domingues RG,Veiga-Fernandes H,Luster AD,Lugering A,Randall TD,Cupedo T,Mebius RE</div> <div itemprop="description">14-0451 was used in Immunofluorescence to distinguish the different mechanisms responsible for the formation of two distinct colonic lymphoid tissues.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24166977"> <div itemprop="name">Unique features of naive CD8+ T cell activation by IL-2.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J</div> <div itemprop="description">14-0451 was used in in vitro experiments to demonstrate that IL-2 elicits a unique signaling pattern associated with strong lymphocyte-specific protein tyrosine kinase/JAK3-dependent activation of the PI3K/AKT pathway.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24106006"> <div itemprop="name">Interferon gamma causes olfactory dysfunction without concomitant neuroepithelial damage.</div> </a> <div itemprop="about">International forum of allergy & rhinology</div> <div itemprop="author">Pozharskaya T,Lane AP</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to investigate the direct effect of IFN-γ on olfactory neuron function that may underlie olfactory loss in CRSsNP or viral infections.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23562810"> <div itemprop="name">The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Lee SY,Goverman JM</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to analyse the role of Tim-3 signalling within various innate immune cells on the development of experimental autoimmune encephalomyelitis.</div> <div itemprodp="datePublished">Wed May 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23267022"> <div itemprop="name">Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Zhang F,Wei W,Chai H,Xie X</div> <div itemprop="description">14-0451 was used in Immunofluorescence on frozen tissues to investigate the effect of aurintricarboxylic acid (ATA) on experimental autoimmune encephalomyelitis (EAE), showing that ATA ameliorates EAE by blocking chemokine-mediated pathogenic cell migration and infiltration.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23211619"> <div itemprop="name">Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity.</div> </a> <div itemprop="about">Journal of immunotherapy (Hagerstown, Md. : 1997)</div> <div itemprop="author">Barr KM,Jing W,Hallett WH,Gershan JA,Johnson BD</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to examine immune effectors at vaccine sites to identify mechanisms responsible for the generation of ineffective antitumor immunity, providing insights to dysfunctional T-cell immunity.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23370675"> <div itemprop="name">Stromal cells participate in the murine esophageal mucosal injury response.</div> </a> <div itemprop="about">American journal of physiology. Gastrointestinal and liver physiology</div> <div itemprop="author">Shaker A,Binkley J,Darwech I,Swietlicki E,McDonald K,Newberry R,Rubin DC</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the involvement of esophageal mesenchymal cells expressing α-smooth muscle actin (α-SMA) and vimentin during esophageal injury and repair.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23657854"> <div itemprop="name">Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI.</div> </a> <div itemprop="about">American journal of physiology. Renal physiology</div> <div itemprop="author">Winterberg PD,Wang Y,Lin KM,Hartono JR,Nagami GT,Zhou XJ,Shelton JM,Richardson JA,Lu CY</div> <div itemprop="description">14-0451-82 was used in Magnetic cell separation to show that interferon regulatory factor 1 mediates reactive oxygen species signalling, generated during ischemic acute kidney injury and induces interferon-α production.</div> <div itemprodp="datePublished">Mon Jul 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23980105"> <div itemprop="name">CD38 controls the innate immune response against Listeria monocytogenes.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Lischke T,Heesch K,Schumacher V,Schneider M,Haag F,Koch-Nolte F,Mittrücker HW</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to evaluate the key enzymes governing the innate immune response.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24324557"> <div itemprop="name">Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Tarafdar A,Dobbin E,Corrigan P,Freeburn R,Wheadon H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Tue Jul 29 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24012753"> <div itemprop="name">Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Poulos MG,Guo P,Kofler NM,Pinho S,Gutkin MC,Tikhonova A,Aifantis I,Frenette PS,Kitajewski J,Rafii S,Butler JM</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that Jagged-1 expressed in the bone marrow vascular niche regulates homeostatic and regenerative haematopoiesis through a Notch-dependent mechanism.</div> <div itemprodp="datePublished">Thu Sep 12 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24396708"> <div itemprop="name">Activation and crosstalk between TNF family receptors in umbilical cord blood cells is not responsible for loss of engraftment capacity following culture.</div> </a> <div itemprop="about">American journal of stem cells</div> <div itemprop="author">Mizrahi K,Askenasy N</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to assess crosstalk between the Fas, TNF and TRAIL receptors, to determine whether it contributes to increased mortality and decreased activity of UCB progenitors.</div> <div itemprodp="datePublished">Tue Jan 07 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23585844"> <div itemprop="name">In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemia in NSG mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">von Bonin M,Wermke M,Cosgun KN,Thiede C,Bornhauser M,Wagemaker G,Waskow C</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind the limitations of xenotransplantation assays of cells from leukaemia patients into immune compromised mice.</div> <div itemprodp="datePublished">Tue Oct 22 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23520544"> <div itemprop="name">Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">El-Zaatari M,Kao JY,Tessier A,Bai L,Hayes MM,Fontaine C,Eaton KA,Merchant JL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 10 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24044641"> <div itemprop="name">Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Kohman RA,Bhattacharya TK,Wojcik E,Rhodes JS</div> <div itemprop="description">14-0451-82 was used in Flow cytometry/Cell sorting to indicate that running-wheel access modulates microglia activation, but these effects vary by age, sex, and brain region.</div> <div itemprodp="datePublished">Wed Sep 18 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22820644"> <div itemprop="name">The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Schmidt EP,Yang Y,Janssen WJ,Gandjeva A,Perez MJ,Barthel L,Zemans RL,Bowman JC,Koyanagi DE,Yunt ZX,Smith LP,Cheng SS,Overdier KH,Thompson KR,Geraci MW,Douglas IS,Pearse DB,Tuder RM</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to elucidate the mechanisms by which glycocalyx loss occurs during sepsis, and how this allows for neutrophil adhesion within the pulmonary circulation.</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22425250"> <div itemprop="name">Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Roberts NA,White AJ,Jenkinson WE,Turchinovich G,Nakamura K,Withers DR,McConnell FM,Desanti GE,Benezech C,Parnell SM,Cunningham AF,Paolino M,Penninger JM,Simon AK,Nitta T,Ohigashi I,Takahama Y,Caamano JH,Hayday AC,Lane PJ,Jenkinson EJ,Anderson G</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the temporal development of Vγ5(+) γδ T cells during thymus medulla formation.</div> <div itemprodp="datePublished">Fri Mar 23 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22464170"> <div itemprop="name">Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.</div> <div itemprodp="datePublished">Fri Apr 20 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22340596"> <div itemprop="name">Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Buchstaller J,McKeever PE,Morrison SJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 14 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22440612"> <div itemprop="name">Autophagy links inflammasomes to atherosclerotic progression.</div> </a> <div itemprop="about">Cell metabolism</div> <div itemprop="author">Razani B,Feng C,Coleman T,Emanuel R,Wen H,Hwang S,Ting JP,Virgin HW,Kastan MB,Semenkovich CF</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Wed Apr 04 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22729249"> <div itemprop="name">IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Wang Y,Szretter KJ,Vermi W,Gilfillan S,Rossini C,Cella M,Barrow AD,Diamond MS,Colonna M</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate whether IL-34 is responsible for the lack of Langerhans cells and microglia in CSF1R-deficient mice.</div> <div itemprodp="datePublished">Sun Jun 24 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22993390"> <div itemprop="name">Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.</div> <div itemprodp="datePublished">Thu Dec 06 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22472773"> <div itemprop="name">Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Rayamajhi M,Delgado C,Condon TV,Riches DW,Lenz LL</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate mechanisms of Bacillus anthracis spore traffic from the lungs to the lung-draining lymph nodes in a mouse model of inhalation anthrax.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22628281"> <div itemprop="name">Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23036899"> <div itemprop="name">Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Syu LJ,El-Zaatari M,Eaton KA,Liu Z,Tetarbe M,Keeley TM,Pero J,Ferris J,Wilbert D,Kaatz A,Zheng X,Qiao X,Grachtchouk M,Gumucio DL,Merchant JL,Samuelson LC,Dlugosz AA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22222225"> <div itemprop="name">Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">McDonald KG,Leach MR,Brooke KWM,Wang C,Wheeler LW,Hanly EK,Rowley CW,Levin MS,Wagner M,Li E,Newberry RD</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to study dendritic cell production of all-trans retinoic acid (ATRA) in vivo.</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22844125"> <div itemprop="name">Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Yang RK,Kalogriopoulos NA,Rakhmilevich AL,Ranheim EA,Seo S,Kim K,Alderson KL,Gan J,Reisfeld RA,Gillies SD,Hank JA,Sondel PM</div> <div itemprop="description">14-0451 was used in Immunohistochemistry to study how IT-IC resulted in increased numbers of activated T and NK cells within tumours, better IC retention in the tumour, enhanced inhibition of tumour growth, and improved survival compared with i.v.-IC.</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22686371"> <div itemprop="name">A model of GAG/MIP-2/CXCR2 interfaces and its functional effects.</div> </a> <div itemprop="about">Biochemistry</div> <div itemprop="author">Rajasekaran D,Keeler C,Syed MA,Jones MC,Harrison JK,Wu D,Bhandari V,Hodsdon ME,Lolis EJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 17 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22363815"> <div itemprop="name">Tissue specific deletion of inhibitor of kappa B kinase 2 with OX40-Cre reveals the unanticipated expression from the OX40 locus in skin epidermis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Cornish GH,Tung SL,Marshall D,Ley S,Seddon BP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Fri Jun 29 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23284862"> <div itemprop="name">Delta-like ligand (DLL)1 expression in early mouse decidua and its localization to uterine natural killer cells.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Degaki KY,Chen Z,Yamada AT,Croy BA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Tue Jun 25 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22472278"> <div itemprop="name">Cell type-associated differences in migration, survival, and immunogenicity following grafting in CNS tissue.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Praet J,Reekmans K,Lin D,De Vocht N,Bergwerf I,Tambuyzer B,Daans J,Hens N,Goossens H,Pauwels P,Berneman Z,Van der Linden A,Ponsaerts P</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 06 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23066023"> <div itemprop="name">Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Tosello-Trampont AC,Landes SG,Nguyen V,Novobrantseva TI,Hahn YS</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to define the mechanisms that trigger nonalcoholic steatohepatitis.</div> <div itemprodp="datePublished">Fri Nov 23 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22005300"> <div itemprop="name">Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Cheung R,Shen F,Phillips JH,McGeachy MJ,Cua DJ,Heyworth PG,Pierce RH</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to identify the MDL-1/Syk/PI3K/Akt/eNOS pathway as a potential new target for the prevention of the progression of SIRS to shock.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21633411"> <div itemprop="name">Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4.</div> </a> <div itemprop="about">Kidney international</div> <div itemprop="author">Chen J,Hartono JR,John R,Bennett M,Zhou XJ,Wang Y,Wu Q,Winterberg PD,Nagami GT,Lu CY</div> <div itemprop="description">14-0451 was used in Immunopurification to study the regulation of leukocytes' early interleukin 6 production during ischemic acute kidney injury.</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21825019"> <div itemprop="name">Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Tagliani E,Shi C,Nancy P,Tay CS,Pamer EG,Erlebacher A</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to provide insight into the regulation of MΦ tissue densities under noninflammatory conditions and reveal a central role for CSF-1 in the coordination of MΦ and DC homeostasis.</div> <div itemprodp="datePublished">Mon Aug 29 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21514665"> <div itemprop="name">Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy.</div> </a> <div itemprop="about">Biomaterials</div> <div itemprop="author">Kwong B,Liu H,Irvine DJ</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate whether systemic exposure to immuno-agonist compounds could be limited to local tumour tissue, showing that liposome-anchored combinatorial immunotherapy could induce potent anti-tumor response.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21525884"> <div itemprop="name">A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis.</div> </a> <div itemprop="about">The Journal of investigative dermatology</div> <div itemprop="author">Kautz-Neu K,Kostka SL,Dinges S,Iwakura Y,Udey MC,von Stebut E</div> <div itemprop="description">14-0451 was used in an ELISA assay to suggest that in addition to effects on Th education, IL-1α/β signalling also modulates DC homeostasis with increased signalling, leading to down-modulation of IL-12 synthesis and worsened disease outcome after infection with Leishmania major.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21525884"> <div itemprop="name">A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis.</div> </a> <div itemprop="about">The Journal of investigative dermatology</div> <div itemprop="author">Kautz-Neu K,Kostka SL,Dinges S,Iwakura Y,Udey MC,von Stebut E</div> <div itemprop="description">14-0451 was used in an ELISA assay to suggest that in addition to effects on Th education, IL-1α/β signalling also modulates DC homeostasis with increased signalling, leading to down-modulation of IL-12 synthesis and worsened disease outcome after infection with Leishmania major.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21989919"> <div itemprop="name">ER71 directs mesodermal fate decisions during embryogenesis.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21340652"> <div itemprop="name">The anti-tumor effect of resveratrol alone or in combination with immunotherapy in a neuroblastoma model.</div> </a> <div itemprop="about">Cancer immunology, immunotherapy : CII</div> <div itemprop="author">Soto BL,Hank JA,Van De Voort TJ,Subramanian L,Polans AS,Rakhmilevich AL,Yang RK,Seo S,Kim K,Reisfeld RA,Gillies SD,Sondel PM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21178002"> <div itemprop="name">Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Atibalentja DF,Murphy KM,Unanue ER</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to evaluate the presentation of blood-derived protein Ags by antigen presenting cells in the thymus.</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21296809"> <div itemprop="name">Effect of topical azithromycin on corneal innate immune responses.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Sadrai Z,Hajrasouliha AR,Chauhan S,Saban DR,Dastjerdi MH,Dana R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 19 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21703864"> <div itemprop="name">Myeloid cells migrate in response to IL-24.</div> </a> <div itemprop="about">Cytokine</div> <div itemprop="author">Buzas K,Oppenheim JJ,Zack Howard OM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21365015"> <div itemprop="name">Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">McFarland AP,Savan R,Wagage S,Addison A,Ramakrishnan K,Karwan M,Duong T,Young HA</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to identify a correlation between the loss/down-regulation of IFNAR1 on DCs and exacerbation of colitis.</div> <div itemprodp="datePublished">Fri Feb 18 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21092405"> <div itemprop="name">Clinical potential of intravenous neural stem cell delivery for treatment of neuroinflammatory disease in mice?</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Reekmans KP,Praet J,De Vocht N,Tambuyzer BR,Bergwerf I,Daans J,Baekelandt V,Vanhoutte G,Goossens H,Jorens PG,Ysebaert DK,Chatterjee S,Pauwels P,Van Marck E,Berneman ZN,Van der Linden A,Ponsaerts P</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 09 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21714479"> <div itemprop="name">Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes.</div> </a> <div itemprop="about">Cancer immunity</div> <div itemprop="author">Wu TH,Schreiber K,Arina A,Khodarev NN,Efimova EV,Rowley DA,Weichselbaum RR,Schreiber H</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to characterize stepwise progression of an antigenic tumor and show that different mechanisms work to prevent tumor cell recognition and elimination.</div> <div itemprodp="datePublished">Thu Jun 30 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20404100"> <div itemprop="name">Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Danzl NM,Donlin LT,Alexandropoulos K</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to reveal the role of the signalling protein Sin in the thymic stroma, specifically in medullary thymic epithelial cells.</div> <div itemprodp="datePublished">Mon May 10 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21056990"> <div itemprop="name">CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Kim M,Koh YJ,Kim KE,Koh BI,Nam DH,Alitalo K,Kim I,Koh GY</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the mechanisms responsible for the aggressive characteristics of malignant melanomas, showing that CXCR4 signaling regulates metastasis.</div> <div itemprodp="datePublished">Wed Dec 15 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19487812"> <div itemprop="name">The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Kuhn M,Völker K,Schwarz K,Carbajo-Lozoya J,Flögel U,Jacoby C,Stypmann J,van Eickels M,Gambaryan S,Hartmann M,Werner M,Wieland T,Schrader J,Baba HA</div> <div itemprop="description">14-0451 was used in Immunohistochemistry on paraffin embedded tissues to identify a novel function of cardiac atrial natriuretic peptide and B-type natriuretic peptide as paracrine regulators of vascular regeneration.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19020532"> <div itemprop="name">Mice that overexpress human heat shock protein 27 have increased renal injury following ischemia reperfusion.</div> </a> <div itemprop="about">Kidney international</div> <div itemprop="author">Chen SW,Kim M,Kim M,Song JH,Park SW,Wells D,Brown K,Belleroche Jd,D'Agati VD,Lee HT</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate increased renal injury in mice that overexpress human heat shock protein 27 following ischemia reperfusion.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19085956"> <div itemprop="name">Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development.</div> </a> <div itemprop="about">Hepatology (Baltimore, Md.)</div> <div itemprop="author">Asahina K,Tsai SY,Li P,Ishii M,Maxson RE,Sucov HM,Tsukamoto H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19360122"> <div itemprop="name">The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Shimada K,Chen S,Dempsey PW,Sorrentino R,Alsabeh R,Slepenkin AV,Peterson E,Doherty TM,Underhill D,Crother TR,Arditi M</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the role of the Nod/Rip2 pathway in responses to Chlamydophila pneumoniae infection, showing that it is essential for host defences against pneumonia.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19452445"> <div itemprop="name">Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Kunimoto K,Nojima H,Yamazaki Y,Yoshikawa T,Okanoue T,Tsukita S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Immunofluorescence</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19574419"> <div itemprop="name">Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells.</div> </a> <div itemprop="about">American journal of physiology. Lung cellular and molecular physiology</div> <div itemprop="author">Cagnina RE,Ramos SI,Marshall MA,Wang G,Frazier CR,Linden J</div> <div itemprop="description">14-0451 was used in Functional assays to determine the sites of expression of the A(2B) receptor in the mouse lung, showing that they are highly expressed on murine type II alveolar epithelial cells.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19864606"> <div itemprop="name">Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Graham KL,Zabel BA,Loghavi S,Zuniga LA,Ho PP,Sobel RA,Butcher EC</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the involvement of chemokine-like receptor-1 in experimental autoimmune encephalomyelitis.</div> <div itemprodp="datePublished">Sun Nov 15 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19264338"> <div itemprop="name">Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.</div> </a> <div itemprop="about">Virology</div> <div itemprop="author">Steel CD,Hahto SM,Ciavarra RP</div> <div itemprop="description">14-0451-82 was used in Flow Cytometry to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.</div> <div itemprodp="datePublished">Sat Apr 25 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18464929"> <div itemprop="name">p21Cip1 modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Olive M,Mellad JA,Beltran LE,Ma M,Cimato T,Noguchi AC,San H,Childs R,Kovacic JC,Boehm M</div> <div itemprop="description">14-0451 was used in Immunofluorescence on frozen tissues to show that p21Cip1 orchestrates the complex interactions between local vascular and circulating immune cells during vascular wound repair.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18566405"> <div itemprop="name">Th1 and Th2 cells form morphologically distinct immunological synapses.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Thauland TJ,Koguchi Y,Wetzel SA,Dustin ML,Parker DC</div> <div itemprop="description">14-0451 was used in Immunocytochemistry-immunoflourescence to indicate that the immunological synapse formed by Th1 and Th2 cells are distinct in structure.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18558197"> <div itemprop="name">Donor major histocompatibility complex class I expression determines the outcome of prenatal transplantation.</div> </a> <div itemprop="about">Journal of pediatric surgery</div> <div itemprop="author">Durkin ET,Jones KA,Elnaggar D,Shaaban AF</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate whether donor cell MHC class I expression facilitates engraftment in prenatal allogeneic recipients, showing that it determines the outcome of prenatal transplantation.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17702899"> <div itemprop="name">Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Chappaz S,Flueck L,Farr AG,Rolink AG,Finke D</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to investigate the role of TSLP in lymphopoiesis and immune cell development in IL-7-deficient mice.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17661344"> <div itemprop="name">Optimized isolation enables ex vivo analysis of microglia from various central nervous system regions.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">de Haas AH,Boddeke HW,Brouwer N,Biber K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 14-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17897956"> <div itemprop="name">Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Chen IJ,Chen HL,Demetriou M</div> <div itemprop="description">14-0451 was used in Immunofluorescence to investigate the role of the galectin lattice and actin cytoskeleton in controlling microdomain structure and coordinating signal transduction across the plasma membrane.</div> <div itemprodp="datePublished">Fri Nov 30 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16938836"> <div itemprop="name">Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Coles MC,Veiga-Fernandes H,Foster KE,Norton T,Pagakis SN,Seddon B,Kioussis D</div> <div itemprop="description">14-0451 was used in Flow cytometry/Cell sorting to reveal a potential role for mature lymphocytes and IL7/IL7r interactions in postnatal lymph node development.</div> <div itemprodp="datePublished">Tue Sep 05 00:00:00 EDT 2006</div> </div> </noscript> </div> <div class="border-bottom"></div> <div class="product-bioinformatics-details"> <div class="container"> <h2 class="pdp-sub-heading">Bioinformatics</h2> <div class="row"> <div class="large-span-6 medium-span-12 small-span-12"> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="proteinContent"> <strong>Protein Aliases:</strong> CD45; L-CA; Leukocyte common antigen; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Receptor-type tyrosine-protein phosphatase C; T200; T220 and B220 </p> <p class="view-buttons" id="ptnViewBtn" ng-class="$ctrl.bioContentLines('proteinContent', 'ptnViewBtn')"> <a id="proteinViewMoreBtn" ng-click="$ctrl.bioContentViewMore('proteinViewMoreBtn', 'proteinViewLessBtn', 'proteinContent')"> View more </a> <a id="proteinViewLessBtn" ng-click="$ctrl.bioContentViewLess('proteinViewLessBtn', 'proteinViewMoreBtn', 'proteinContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="geneContent"> <strong>Gene Aliases:</strong> B220; Cd45; CD45R; L-CA; loc; Ly-5; Lyt-4; Ptprc; T200 </p> <p class="view-buttons" id="geneViewBtn" ng-class="$ctrl.bioContentLines('geneContent', 'geneViewBtn')"> <a id="geneViewMoreBtn" ng-click="$ctrl.bioContentViewMore('geneViewMoreBtn', 'geneViewLessBtn', 'geneContent')"> View more </a> <a id="geneViewLessBtn" ng-click="$ctrl.bioContentViewLess('geneViewLessBtn', 'geneViewMoreBtn', 'geneContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="unitProContent"> <strong>UniProt ID:</strong> <a href="http://www.uniprot.org/uniprot/P06800" target="_blank">(Mouse) P06800</a> </p> <p class="view-buttons" id="unitViewBtn" ng-class="$ctrl.bioContentLines('unitProContent', 'unitViewBtn')"> <a id="unitProViewMoreBtn" ng-click="$ctrl.bioContentViewMore('unitProViewMoreBtn', 'unitProViewLessBtn', 'unitProContent')"> View more </a> <a id="unitProViewLessBtn" ng-click="$ctrl.bioContentViewLess('unitProViewLessBtn', 'unitProViewMoreBtn', 'unitProContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="entrezContent"> <strong>Entrez Gene ID:</strong> <a href="http://www.ncbi.nlm.nih.gov/gene?term=19264" target="_blank">(Mouse) 19264</a> </p> <p class="view-buttons" id="etzViewBtn" ng-class="$ctrl.bioContentLines('entrezContent', 'etzViewBtn')"> <a id="entrezViewMoreBtn" ng-click="$ctrl.bioContentViewMore('entrezViewMoreBtn', 'entrezViewLessBtn', 'entrezContent')"> View more </a> <a id="entrezViewLessBtn" ng-click="$ctrl.bioContentViewLess('entrezViewLessBtn', 'entrezViewMoreBtn', 'entrezContent')"> View less </a> </p> </div> </div> <div class="large-span-6 medium-span-12 small-span-12"> <div class="accordion" id="accordion-bioinformatics"> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseOne"> Function(s) </a> </div> <div id="collapseOne" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/phosphoprotein phosphatase activity"> phosphoprotein phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/protein tyrosine phosphatase activity"> protein tyrosine phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/protein binding"> protein binding </a> <a class="icon" href="/antibody/primary/panther/heparin binding"> heparin binding </a> <a class="icon" href="/antibody/primary/panther/hydrolase activity"> hydrolase activity </a> <a class="icon" href="/antibody/primary/panther/phosphatase activity"> phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/protein kinase binding"> protein kinase binding </a> <a class="icon" href="/antibody/primary/panther/heparan sulfate proteoglycan binding"> heparan sulfate proteoglycan binding </a> <a class="icon" href="/antibody/primary/panther/protein phosphatase"> protein phosphatase </a> <a class="icon" href="/antibody/primary/panther/protein modifying enzyme"> protein modifying enzyme </a> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseTwo"> Process(es) </a> </div> <div id="collapseTwo" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/activation of MAPK activity"> activation of MAPK activity </a> <a class="icon" href="/antibody/primary/panther/negative regulation of T cell mediated cytotoxicity"> negative regulation of T cell mediated cytotoxicity </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell mediated cytotoxicity"> positive regulation of T cell mediated cytotoxicity </a> <a class="icon" href="/antibody/primary/panther/negative regulation of cytokine-mediated signaling pathway"> negative regulation of cytokine-mediated signaling pathway </a> <a class="icon" href="/antibody/primary/panther/hematopoietic progenitor cell differentiation"> hematopoietic progenitor cell differentiation </a> <a class="icon" href="/antibody/primary/panther/immunoglobulin biosynthetic process"> immunoglobulin biosynthetic process </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell mediated immunity"> positive regulation of T cell mediated immunity </a> <a class="icon" href="/antibody/primary/panther/regulation of humoral immune response mediated by circulating immunoglobulin"> regulation of humoral immune response mediated by circulating immunoglobulin </a> <a class="icon" href="/antibody/primary/panther/positive regulation of humoral immune response mediated by circulating immunoglobulin"> positive regulation of humoral immune response mediated by circulating immunoglobulin </a> <a class="icon" href="/antibody/primary/panther/negative regulation of protein kinase activity"> negative regulation of protein kinase activity </a> <a class="icon" href="/antibody/primary/panther/protein dephosphorylation"> protein dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/negative regulation of cell adhesion involved in substrate-bound cell migration"> negative regulation of cell adhesion involved in substrate-bound cell migration </a> <a class="icon" href="/antibody/primary/panther/leukocyte cell-cell adhesion"> leukocyte cell-cell adhesion </a> <a class="icon" href="/antibody/primary/panther/response to gamma radiation"> response to gamma radiation </a> <a class="icon" href="/antibody/primary/panther/dephosphorylation"> dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/B cell differentiation"> B cell differentiation </a> <a class="icon" href="/antibody/primary/panther/T cell differentiation"> T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of B cell proliferation"> positive regulation of B cell proliferation </a> <a class="icon" href="/antibody/primary/panther/negative regulation of protein autophosphorylation"> negative regulation of protein autophosphorylation </a> <a class="icon" href="/antibody/primary/panther/heterotypic cell-cell adhesion"> heterotypic cell-cell adhesion </a> <a class="icon" href="/antibody/primary/panther/peptidyl-tyrosine dephosphorylation"> peptidyl-tyrosine dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/T cell proliferation"> T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/B cell proliferation"> B cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell proliferation"> positive regulation of T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of MAPK cascade"> positive regulation of MAPK cascade </a> <a class="icon" href="/antibody/primary/panther/cell cycle phase transition"> cell cycle phase transition </a> <a class="icon" href="/antibody/primary/panther/positive thymic T cell selection"> positive thymic T cell selection </a> <a class="icon" href="/antibody/primary/panther/negative thymic T cell selection"> negative thymic T cell selection </a> <a class="icon" href="/antibody/primary/panther/regulation of B cell differentiation"> regulation of B cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell differentiation"> positive regulation of T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of gamma-delta T cell differentiation"> positive regulation of gamma-delta T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of alpha-beta T cell proliferation"> positive regulation of alpha-beta T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of isotype switching to IgG isotypes"> positive regulation of isotype switching to IgG isotypes </a> <a class="icon" href="/antibody/primary/panther/bone marrow development"> bone marrow development </a> <a class="icon" href="/antibody/primary/panther/stem cell development"> stem cell development </a> <a class="icon" href="/antibody/primary/panther/negative regulation of peptidyl-tyrosine phosphorylation"> negative regulation of peptidyl-tyrosine phosphorylation </a> <a class="icon" href="/antibody/primary/panther/T cell receptor signaling pathway"> T cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/B cell receptor signaling pathway"> B cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/regulation of B cell receptor signaling pathway"> regulation of B cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/positive regulation of antigen receptor-mediated signaling pathway"> positive regulation of antigen receptor-mediated signaling pathway </a> <a class="icon" href="/antibody/primary/panther/release of sequestered calcium ion into cytosol"> release of sequestered calcium ion into cytosol </a> <a class="icon" href="/antibody/primary/panther/defense response to virus"> defense response to virus </a> <a class="icon" href="/antibody/primary/panther/regulation of cell cycle"> regulation of cell cycle </a> <a class="icon" href="/antibody/primary/panther/positive regulation of hematopoietic stem cell migration"> positive regulation of hematopoietic stem cell migration </a> <a class="icon" href="/antibody/primary/panther/positive regulation of stem cell proliferation"> positive regulation of stem cell proliferation </a> <a class="icon" href="/antibody/primary/panther/regulation of extrinsic apoptotic signaling pathway"> regulation of extrinsic apoptotic signaling pathway </a> <a class="icon" href="/antibody/primary/panther/positive regulation of extrinsic apoptotic signaling pathway"> positive regulation of extrinsic apoptotic signaling pathway </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="recommended-products border-bottom hidden">  It has to be done as per old AB suggested Products section. </div> <script type="text/javascript" src="/order/genome-database/assets/core/js/magellanCore.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript"> $m.addPerformanceMark('abPDPScripts:loadBegin'); </script> <script type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/angular108-document-scripts.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" 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