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data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><p class="mw-empty-elt"> </p> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">For other uses, see <a href="/wiki/HCK_(disambiguation)" class="mw-disambig" title="HCK (disambiguation)">HCK (disambiguation)</a>.</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">HCK</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_HCK_PDB_1ad5.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Protein_HCK_PDB_1ad5.png/250px-Protein_HCK_PDB_1ad5.png" decoding="async" width="250" height="172" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Protein_HCK_PDB_1ad5.png/375px-Protein_HCK_PDB_1ad5.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Protein_HCK_PDB_1ad5.png/500px-Protein_HCK_PDB_1ad5.png 2x" data-file-width="977" data-file-height="671" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P08103%20or%20P08631">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P08103,P08631">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1AD5">1AD5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1BU1">1BU1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1QCF">1QCF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2C0I">2C0I</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2C0O">2C0O</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2C0T">2C0T</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2HCK">2HCK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2HK5">2HK5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2OI3">2OI3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2OJ2">2OJ2</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3HCK">3HCK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3NHN">3NHN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3RBB">3RBB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3REA">3REA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3REB">3REB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VRY">3VRY</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VRZ">3VRZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VS0">3VS0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VS1">3VS1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VS2">3VS2</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VS3">3VS3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VS4">3VS4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VS5">3VS5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VS6">3VS6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VS7">3VS7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4HCK">4HCK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4LUD">4LUD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4LUE">4LUE</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4ORZ">4ORZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4U5W">4U5W</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5HCK">5HCK</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/4840">HCK</a></span>, JTK9, p59Hck, p61Hck, HCK proto-oncogene, Src family tyrosine kinase</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/142370">142370</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:96052">96052</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=20489">20489</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=HCK">HCK</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000101336">HCK - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_20.svg" class="mw-file-description" title="Chromosome 20 (human)"><img alt="Chromosome 20 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/ff/Ideogram_human_chromosome_20.svg/300px-Ideogram_human_chromosome_20.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/ff/Ideogram_human_chromosome_20.svg/450px-Ideogram_human_chromosome_20.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/ff/Ideogram_human_chromosome_20.svg/600px-Ideogram_human_chromosome_20.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_20_(human)" class="mw-redirect" title="Chromosome 20 (human)">Chromosome 20 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_20_ideogram.svg" class="mw-file-description" title="Chromosome 20 (human)"><img alt="Chromosome 20 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Human_chromosome_20_ideogram.svg/300px-Human_chromosome_20_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Human_chromosome_20_ideogram.svg/450px-Human_chromosome_20_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Human_chromosome_20_ideogram.svg/600px-Human_chromosome_20_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 141.00453729396px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for HCK"><img alt="Genomic location for HCK" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 147px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for HCK"><img alt="Genomic location for HCK" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">20q11.21</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">32,052,197 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">32,101,856 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_2.svg" class="mw-file-description" title="Chromosome 2 (mouse)"><img alt="Chromosome 2 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/330px-Ideogram_house_mouse_chromosome_2.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/390px-Ideogram_house_mouse_chromosome_2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/520px-Ideogram_house_mouse_chromosome_2.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 2 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_2.svg" class="mw-file-description" title="Chromosome 2 (mouse)"><img alt="Chromosome 2 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Ideogram_of_house_mouse_chromosome_2.svg/300px-Ideogram_of_house_mouse_chromosome_2.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Ideogram_of_house_mouse_chromosome_2.svg/450px-Ideogram_of_house_mouse_chromosome_2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Ideogram_of_house_mouse_chromosome_2.svg/600px-Ideogram_of_house_mouse_chromosome_2.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 241.66666527788px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for HCK"><img alt="Genomic location for HCK" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 247.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for HCK"><img alt="Genomic location for HCK" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">2 H1|2 75.41 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">152,950,388 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">152,993,361 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000101336">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">monocyte</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">bone marrow</li><br /><li style="line-height: 137%;">appendix</li><br /><li style="line-height: 137%;">trabecular bone</li><br /><li style="line-height: 137%;">middle frontal gyrus</li><br /><li style="line-height: 137%;">bone marrow cells</li><br /><li style="line-height: 137%;">periodontal fiber</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000003283">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">stroma of bone marrow</li><br /><li style="line-height: 137%;">tibiofemoral joint</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">rib</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">right lung lobe</li><br /><li style="line-height: 137%;">transitional epithelium of urinary bladder</li><br /><li style="line-height: 137%;">left lung</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000101336">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_HCK_208018_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/PBB_GE_HCK_208018_s_at_fs.png/250px-PBB_GE_HCK_208018_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/PBB_GE_HCK_208018_s_at_fs.png/375px-PBB_GE_HCK_208018_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/PBB_GE_HCK_208018_s_at_fs.png/500px-PBB_GE_HCK_208018_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/3055/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016740">transferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000166">nucleotide binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004672">protein kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004715">non-membrane spanning protein tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016301">kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005102">signaling receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005524">ATP binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004713">protein tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001784">phosphotyrosine residue binding</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005794">Golgi apparatus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042995">cell projection</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005925">focal adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031234">extrinsic component of cytoplasmic side of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030133">transport vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030054">cell junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005884">actin filament</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005901">caveola</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005764">lysosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005856">cytoskeleton</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031410">cytoplasmic vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002522">leukocyte migration involved in immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030838">positive regulation of actin filament polymerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038096">Fc-gamma receptor signaling pathway involved in phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016310">phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007169">transmembrane receptor protein tyrosine kinase signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019221">cytokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060333">interferon-gamma-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002376">immune system process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043299">leukocyte degranulation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043066">negative regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019049">mitigation of host defenses by virus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006468">protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045728">respiratory burst after phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051090">regulation of DNA-binding transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050727">regulation of inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008360">regulation of cell shape</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071801">regulation of podosome assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038083">peptidyl-tyrosine autophosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006909">phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007229">integrin-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046777">protein autophosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0018108">peptidyl-tyrosine phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050764">regulation of phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007498">mesoderm development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006954">inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002758">innate immune response-activating signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000251">positive regulation of actin cytoskeleton reorganization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031663">lipopolysaccharide-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006887">exocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016032">viral process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045087">innate immune response</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=3055&rn=1">3055</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=15162&rn=1">15162</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000101336;db=core">ENSG00000101336</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000003283;db=core">ENSMUSG00000003283</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P08631">P08631</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P08103">P08103</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_002110">NM_002110</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001172129">NM_001172129</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001172130">NM_001172130</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001172131">NM_001172131</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001172132">NM_001172132</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001172133">NM_001172133</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001172117">NM_001172117</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_010407">NM_010407</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001165600">NP_001165600</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001165601">NP_001165601</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001165602">NP_001165602</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001165603">NP_001165603</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001165604">NP_001165604</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_002101">NP_002101</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001165588">NP_001165588</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_034537">NP_034537</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr20:32052197-32101856">Chr 20: 32.05 – 32.1 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr2:152950388-152993361">Chr 2: 152.95 – 152.99 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18026836" class="extiw" title="d:Q18026836">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18251150" class="extiw" title="d:Q18251150">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Tyrosine-protein kinase HCK</b> is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i>HCK</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid3496523_5-0" class="reference"><a href="#cite_note-pmid3496523-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HCK&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HCK comprises five distinct domains which include two terminal domains and three SH domains. The N-terminal domain is important for lipid modifications and a C-terminal domain includes a regulatory tyrosine residue. Next, HCK comprises three highly conserved SH domains: SH1, SH2, and SH3. The catalytic SH1 domain houses the kinase's active site. The regulatory SH3 and SH2 domains are tightly bound together when HCK is in an inactive state.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Signaling">Signaling</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HCK&action=edit&section=2" title="Edit section: Signaling"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HCK is localized in the cytoplasm where it executes its functions as a kinase.  In a steady state, HCK remains in an inactive conformation. Upon interaction with stimuli, such as TLR4 or IL-2,<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> C-terminal tyrosine residues of HCK are dephosphorylated by phosphatases, e.g. CD45, and the inactive conformation of HCK is disrupted resulting in HCK activation.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Activated HCK can then phosphorylate downstream molecules such as Bcr/Abl, PI3K/AKT, MAPK/ERK or STAT5 which then participate in myeloid cell polarization, proliferation and migration.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:0_14-0" class="reference"><a href="#cite_note-:0-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> A case study of a patient with a loss of C-terminal tyrosine residue in HCK showed that the patient suffered from severe pneumonia and vasculitis. This was due to increased HCK activity which led to increased myeloid cell migration and effector functions, such as the production of pro-inflammatory cytokines IL1b, IL-6, IL-8, and TNF-a, and the production of reactive oxygen species. These abnormal functions manifested as the infiltration of inflammatory leukocytes into the lungs and skin, resulting in pneumonia and vasculitis.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HCK&action=edit&section=3" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HCK plays a key role during inflammation as it participates in actin-dependent processes like phagocytosis, membrane remodeling, and cell migration. It has also been shown that HCK participates in NLRP3 inflammasome formation and LPS-induced inflammatory response in mice. However, the mechanism of action is yet to be elucidated.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> HCK not only participates in inflammation-associated processes but also in cancerous processes. It has been shown, that HCK is part of a CXCL12/CXCR4 signaling axis that is partially responsible for the migration of leukemic cells in the bone marrow of patients with acute myeloid leukemia. This finding proposes HCK to be a novel target for the treatment of acute myeloid leukemia.<sup id="cite_ref-:0_14-1" class="reference"><a href="#cite_note-:0-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> HCK and the Src family kinases have also been implicated in driving cell survival in drug-tolerant cancer cells. <sup id="cite_ref-:1_17-0" class="reference"><a href="#cite_note-:1-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HCK&action=edit&section=4" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HCK has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/ADAM15" title="ADAM15">ADAM15</a><sup id="cite_ref-pmid11741929_18-0" class="reference"><a href="#cite_note-pmid11741929-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/BCR_gene" class="mw-redirect" title="BCR gene">BCR gene</a>,<sup id="cite_ref-pmid12592324_19-0" class="reference"><a href="#cite_note-pmid12592324-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10849448_20-0" class="reference"><a href="#cite_note-pmid10849448-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Cbl_gene" class="mw-redirect" title="Cbl gene">Cbl gene</a>,<sup id="cite_ref-pmid11896602_21-0" class="reference"><a href="#cite_note-pmid11896602-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10092522_22-0" class="reference"><a href="#cite_note-pmid10092522-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ELMO1" title="ELMO1">ELMO1</a>,<sup id="cite_ref-pmid12029088_23-0" class="reference"><a href="#cite_note-pmid12029088-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">Granulocyte colony-stimulating factor receptor</a>,<sup id="cite_ref-pmid9790917_24-0" class="reference"><a href="#cite_note-pmid9790917-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RAPGEF1" title="RAPGEF1">RAPGEF1</a>,<sup id="cite_ref-pmid14551197_25-0" class="reference"><a href="#cite_note-pmid14551197-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RAS_p21_protein_activator_1" title="RAS p21 protein activator 1">RAS p21 protein activator 1</a>,<sup id="cite_ref-pmid7782336_26-0" class="reference"><a href="#cite_note-pmid7782336-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/RASA3" title="RASA3">RASA3</a>.<sup id="cite_ref-pmid7782336_26-1" class="reference"><a href="#cite_note-pmid7782336-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HCK&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000101336">GRCh38: Ensembl release 89: ENSG00000101336</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li 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"The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains". <i>Leukemia</i>. <b>17</b> (2): <span class="nowrap">283–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.leu.2402778">10.1038/sj.leu.2402778</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12592324">12592324</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:8695384">8695384</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=The+interaction+of+the+Bcr-Abl+tyrosine+kinase+with+the+Src+kinase+Hck+is+mediated+by+multiple+binding+domains&rft.volume=17&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E283-%3C%2Fspan%3E9&rft.date=2003-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A8695384%23id-name%3DS2CID&rft_id=info%3Apmid%2F12592324&rft_id=info%3Adoi%2F10.1038%2Fsj.leu.2402778&rft.aulast=Stanglmaier&rft.aufirst=M&rft.au=Warmuth%2C+M&rft.au=Kleinlein%2C+I&rft.au=Reis%2C+S&rft.au=Hallek%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></span> </li> <li id="cite_note-pmid10849448-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10849448_20-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLionbergerWilsonSmithgall2000" class="citation journal cs1">Lionberger JM, Wilson MB, Smithgall TE (Jun 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.C000126200">"Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck"</a>. <i>The Journal of Biological Chemistry</i>. <b>275</b> (24): <span class="nowrap">18581–</span>5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.C000126200">10.1074/jbc.C000126200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10849448">10849448</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Transformation+of+myeloid+leukemia+cells+to+cytokine+independence+by+Bcr-Abl+is+suppressed+by+kinase-defective+Hck&rft.volume=275&rft.issue=24&rft.pages=%3Cspan+class%3D%22nowrap%22%3E18581-%3C%2Fspan%3E5&rft.date=2000-06&rft_id=info%3Adoi%2F10.1074%2Fjbc.C000126200&rft_id=info%3Apmid%2F10849448&rft.aulast=Lionberger&rft.aufirst=JM&rft.au=Wilson%2C+MB&rft.au=Smithgall%2C+TE&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.C000126200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></span> </li> <li id="cite_note-pmid11896602-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11896602_21-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHowlettRobbins2002" class="citation journal cs1">Howlett CJ, Robbins SM (Mar 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.onc.1205228">"Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation"</a>. <i>Oncogene</i>. <b>21</b> (11): <span class="nowrap">1707–</span>16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.onc.1205228">10.1038/sj.onc.1205228</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11896602">11896602</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:34296309">34296309</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Membrane-anchored+Cbl+suppresses+Hck+protein-tyrosine+kinase+mediated+cellular+transformation&rft.volume=21&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1707-%3C%2Fspan%3E16&rft.date=2002-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A34296309%23id-name%3DS2CID&rft_id=info%3Apmid%2F11896602&rft_id=info%3Adoi%2F10.1038%2Fsj.onc.1205228&rft.aulast=Howlett&rft.aufirst=CJ&rft.au=Robbins%2C+SM&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fsj.onc.1205228&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></span> </li> <li id="cite_note-pmid10092522-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10092522_22-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHowlettBissonResekTigley1999" class="citation journal cs1">Howlett CJ, Bisson SA, Resek ME, Tigley AW, Robbins SM (Apr 1999). "The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". <i>Biochemical and Biophysical Research Communications</i>. <b>257</b> (1): <span class="nowrap">129–</span>38. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.1999.0427">10.1006/bbrc.1999.0427</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10092522">10092522</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=The+proto-oncogene+p120%28Cbl%29+is+a+downstream+substrate+of+the+Hck+protein-tyrosine+kinase&rft.volume=257&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E129-%3C%2Fspan%3E38&rft.date=1999-04&rft_id=info%3Adoi%2F10.1006%2Fbbrc.1999.0427&rft_id=info%3Apmid%2F10092522&rft.aulast=Howlett&rft.aufirst=CJ&rft.au=Bisson%2C+SA&rft.au=Resek%2C+ME&rft.au=Tigley%2C+AW&rft.au=Robbins%2C+SM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></span> </li> <li id="cite_note-pmid12029088-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12029088_23-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFScottZappacostaKimAnnan2002" class="citation journal cs1">Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (Aug 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M202783200">"Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (31): <span class="nowrap">28238–</span>46. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M202783200">10.1074/jbc.M202783200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12029088">12029088</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Identification+of+novel+SH3+domain+ligands+for+the+Src+family+kinase+Hck.+Wiskott-Aldrich+syndrome+protein+%28WASP%29%2C+WASP-interacting+protein+%28WIP%29%2C+and+ELMO1&rft.volume=277&rft.issue=31&rft.pages=%3Cspan+class%3D%22nowrap%22%3E28238-%3C%2Fspan%3E46&rft.date=2002-08&rft_id=info%3Adoi%2F10.1074%2Fjbc.M202783200&rft_id=info%3Apmid%2F12029088&rft.aulast=Scott&rft.aufirst=MP&rft.au=Zappacosta%2C+F&rft.au=Kim%2C+EY&rft.au=Annan%2C+RS&rft.au=Miller%2C+WT&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M202783200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></span> </li> <li id="cite_note-pmid9790917-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9790917_24-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWardMonkhouseCsarTouw1998" class="citation journal cs1">Ward AC, Monkhouse JL, Csar XF, Touw IP, Bello PA (Oct 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". <i>Biochemical and Biophysical Research Communications</i>. <b>251</b> (1): <span class="nowrap">117–</span>23. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.1998.9441">10.1006/bbrc.1998.9441</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9790917">9790917</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=The+Src-like+tyrosine+kinase+Hck+is+activated+by+granulocyte+colony-stimulating+factor+%28G-CSF%29+and+docks+to+the+activated+G-CSF+receptor&rft.volume=251&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E117-%3C%2Fspan%3E23&rft.date=1998-10&rft_id=info%3Adoi%2F10.1006%2Fbbrc.1998.9441&rft_id=info%3Apmid%2F9790917&rft.aulast=Ward&rft.aufirst=AC&rft.au=Monkhouse%2C+JL&rft.au=Csar%2C+XF&rft.au=Touw%2C+IP&rft.au=Bello%2C+PA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></span> </li> <li id="cite_note-pmid14551197-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid14551197_25-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFShivakrupaRadhaSudhakarSwarup2003" class="citation journal cs1">Shivakrupa R, Radha V, Sudhakar C, Swarup G (Dec 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M310656200">"Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain"</a>. <i>The Journal of Biological Chemistry</i>. <b>278</b> (52): <span class="nowrap">52188–</span>94. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M310656200">10.1074/jbc.M310656200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14551197">14551197</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Physical+and+functional+interaction+between+Hck+tyrosine+kinase+and+guanine+nucleotide+exchange+factor+C3G+results+in+apoptosis%2C+which+is+independent+of+C3G+catalytic+domain&rft.volume=278&rft.issue=52&rft.pages=%3Cspan+class%3D%22nowrap%22%3E52188-%3C%2Fspan%3E94&rft.date=2003-12&rft_id=info%3Adoi%2F10.1074%2Fjbc.M310656200&rft_id=info%3Apmid%2F14551197&rft.aulast=Shivakrupa&rft.aufirst=R&rft.au=Radha%2C+V&rft.au=Sudhakar%2C+C&rft.au=Swarup%2C+G&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M310656200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></span> </li> <li id="cite_note-pmid7782336-26"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid7782336_26-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid7782336_26-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBriggsBryantJoveSanderson1995" class="citation journal cs1">Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE (Jun 1995). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.270.24.14718">"The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck"</a>. <i>The Journal of Biological Chemistry</i>. <b>270</b> (24): <span class="nowrap">14718–</span>24. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.270.24.14718">10.1074/jbc.270.24.14718</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7782336">7782336</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=The+Ras+GTPase-activating+protein+%28GAP%29+is+an+SH3+domain-binding+protein+and+substrate+for+the+Src-related+tyrosine+kinase%2C+Hck&rft.volume=270&rft.issue=24&rft.pages=%3Cspan+class%3D%22nowrap%22%3E14718-%3C%2Fspan%3E24&rft.date=1995-06&rft_id=info%3Adoi%2F10.1074%2Fjbc.270.24.14718&rft_id=info%3Apmid%2F7782336&rft.aulast=Briggs&rft.aufirst=SD&rft.au=Bryant%2C+SS&rft.au=Jove%2C+R&rft.au=Sanderson%2C+SD&rft.au=Smithgall%2C+TE&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.270.24.14718&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HCK&action=edit&section=6" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGeyerFacklerPeterlin2001" class="citation journal cs1">Geyer M, Fackler OT, Peterlin BM (2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083955">"Structure--function relationships in HIV-1 Nef"</a>. <i>EMBO Rep</i>. <b>2</b> (7): <span class="nowrap">580–</span>5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fembo-reports%2Fkve141">10.1093/embo-reports/kve141</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083955">1083955</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11463741">11463741</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=EMBO+Rep.&rft.atitle=Structure--function+relationships+in+HIV-1+Nef.&rft.volume=2&rft.issue=7&rft.pages=%3Cspan+class%3D%22nowrap%22%3E580-%3C%2Fspan%3E5&rft.date=2001&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1083955%23id-name%3DPMC&rft_id=info%3Apmid%2F11463741&rft_id=info%3Adoi%2F10.1093%2Fembo-reports%2Fkve141&rft.aulast=Geyer&rft.aufirst=M&rft.au=Fackler%2C+OT&rft.au=Peterlin%2C+BM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1083955&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHCK" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLakeCarrFengMundy2003" class="citation journal cs1">Lake JA, Carr J, Feng F, Mundy L, Burrell 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class="mw-file-description" title="1ad5: SRC FAMILY KINASE HCK-AMP-PNP COMPLEX"><img alt="1ad5: SRC FAMILY KINASE HCK-AMP-PNP COMPLEX" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/70/PDB_1ad5_EBI.jpg/250px-PDB_1ad5_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/70/PDB_1ad5_EBI.jpg/330px-PDB_1ad5_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/70/PDB_1ad5_EBI.jpg/500px-PDB_1ad5_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ad5</b>: SRC FAMILY KINASE HCK-AMP-PNP COMPLEX</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1bu1_EBI.jpg" class="mw-file-description" title="1bu1: SRC FAMILY KINASE HCK SH3 DOMAIN"><img alt="1bu1: SRC FAMILY KINASE HCK SH3 DOMAIN" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/PDB_1bu1_EBI.jpg/180px-PDB_1bu1_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/PDB_1bu1_EBI.jpg/270px-PDB_1bu1_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/78/PDB_1bu1_EBI.jpg/360px-PDB_1bu1_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1bu1</b>: SRC FAMILY KINASE HCK SH3 DOMAIN</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1qcf_EBI.jpg" class="mw-file-description" title="1qcf: CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR"><img alt="1qcf: CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d4/PDB_1qcf_EBI.jpg/180px-PDB_1qcf_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d4/PDB_1qcf_EBI.jpg/270px-PDB_1qcf_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d4/PDB_1qcf_EBI.jpg/360px-PDB_1qcf_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1qcf</b>: CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2c0i_EBI.png" class="mw-file-description" title="2c0i: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983"><img alt="2c0i: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/PDB_2c0i_EBI.png/180px-PDB_2c0i_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/PDB_2c0i_EBI.png/270px-PDB_2c0i_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7e/PDB_2c0i_EBI.png/360px-PDB_2c0i_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2c0i</b>: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2c0o_EBI.png" class="mw-file-description" title="2c0o: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-770041"><img alt="2c0o: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-770041" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/PDB_2c0o_EBI.png/180px-PDB_2c0o_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/PDB_2c0o_EBI.png/270px-PDB_2c0o_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d5/PDB_2c0o_EBI.png/360px-PDB_2c0o_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2c0o</b>: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-770041</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2c0t_EBI.png" class="mw-file-description" title="2c0t: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359"><img alt="2c0t: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/PDB_2c0t_EBI.png/250px-PDB_2c0t_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/PDB_2c0t_EBI.png/330px-PDB_2c0t_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/24/PDB_2c0t_EBI.png/500px-PDB_2c0t_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2c0t</b>: SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2hck_EBI.jpg" class="mw-file-description" title="2hck: SRC FAMILY KINASE HCK-QUERCETIN COMPLEX"><img alt="2hck: SRC FAMILY KINASE HCK-QUERCETIN COMPLEX" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/PDB_2hck_EBI.jpg/180px-PDB_2hck_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/PDB_2hck_EBI.jpg/270px-PDB_2hck_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9c/PDB_2hck_EBI.jpg/360px-PDB_2hck_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2hck</b>: SRC FAMILY KINASE HCK-QUERCETIN COMPLEX</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2hk5_EBI.jpg" class="mw-file-description" title="2hk5: Hck Kinase in Complex with Lck targeted Inhibitor PG-1009247"><img alt="2hk5: Hck Kinase in Complex with Lck targeted Inhibitor PG-1009247" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/85/PDB_2hk5_EBI.jpg/180px-PDB_2hk5_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/85/PDB_2hk5_EBI.jpg/270px-PDB_2hk5_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/85/PDB_2hk5_EBI.jpg/360px-PDB_2hk5_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2hk5</b>: Hck Kinase in Complex with Lck targeted Inhibitor PG-1009247</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2oi3_EBI.png" class="mw-file-description" title="2oi3: NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high affinity ligand (PD1)"><img alt="2oi3: NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high affinity ligand (PD1)" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/31/PDB_2oi3_EBI.png/250px-PDB_2oi3_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/31/PDB_2oi3_EBI.png/330px-PDB_2oi3_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/31/PDB_2oi3_EBI.png/500px-PDB_2oi3_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2oi3</b>: NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high affinity ligand (PD1)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2oj2_EBI.png" class="mw-file-description" title="2oj2: NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high affinity ligand (PD1)"><img alt="2oj2: NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high affinity ligand (PD1)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/PDB_2oj2_EBI.png/180px-PDB_2oj2_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/PDB_2oj2_EBI.png/270px-PDB_2oj2_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fa/PDB_2oj2_EBI.png/360px-PDB_2oj2_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2oj2</b>: NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high affinity ligand (PD1)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_3hck_EBI.jpg" class="mw-file-description" title="3hck: NMR ensemble of the uncomplexed human HCK SH2 domain, 20 structures"><img alt="3hck: NMR ensemble of the uncomplexed human HCK SH2 domain, 20 structures" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cd/PDB_3hck_EBI.jpg/250px-PDB_3hck_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cd/PDB_3hck_EBI.jpg/330px-PDB_3hck_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cd/PDB_3hck_EBI.jpg/500px-PDB_3hck_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>3hck</b>: NMR ensemble of the uncomplexed human HCK SH2 domain, 20 structures</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_4hck_EBI.jpg" class="mw-file-description" title="4hck: HUMAN HCK SH3 DOMAIN, NMR, 25 STRUCTURES"><img alt="4hck: HUMAN HCK SH3 DOMAIN, NMR, 25 STRUCTURES" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3f/PDB_4hck_EBI.jpg/250px-PDB_4hck_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3f/PDB_4hck_EBI.jpg/330px-PDB_4hck_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3f/PDB_4hck_EBI.jpg/500px-PDB_4hck_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>4hck</b>: HUMAN HCK SH3 DOMAIN, NMR, 25 STRUCTURES</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_5hck_EBI.jpg" class="mw-file-description" title="5hck: HUMAN HCK SH3 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE"><img alt="5hck: HUMAN HCK SH3 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/PDB_5hck_EBI.jpg/180px-PDB_5hck_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/PDB_5hck_EBI.jpg/270px-PDB_5hck_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e6/PDB_5hck_EBI.jpg/360px-PDB_5hck_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>5hck</b>: HUMAN HCK SH3 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div 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template">e</abbr></a></li></ul></div><div id="Protein_kinases:_tyrosine_kinases_(EC_2.7.10)82" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein_kinase" title="Protein kinase">Protein kinases</a>: <a href="/wiki/Tyrosine_kinase" title="Tyrosine kinase">tyrosine kinases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 2.7.10)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Receptor_tyrosine_kinases_(EC_2.7.10.1)82" style="font-size:114%;margin:0 4em"><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Receptor tyrosine kinases</a> (EC 2.7.10.1)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">Growth factor receptors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/ErbB" title="ErbB">EGF receptor family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGFR</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">ERBB2</a></li> <li><a href="/wiki/ERBB3" title="ERBB3">ERBB3</a></li> <li><a href="/wiki/ERBB4" title="ERBB4">ERBB4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Insulin_receptor" title="Insulin receptor">Insulin receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">IGF1R</a></li> <li><a href="/wiki/Insulin_receptor" title="Insulin receptor">INSR</a></li> <li><a href="/wiki/INSRR" title="INSRR">INSRR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/RTK_class_III" title="RTK class III">PDGF receptor family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CSF1R</a></li> <li><a href="/wiki/CD135" title="CD135">FLT3</a></li> <li><a href="/wiki/CD117" class="mw-redirect" title="CD117">KIT</a></li> <li><a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGFR</a> (<a href="/wiki/PDGFRA" class="mw-redirect" title="PDGFRA">PDGFRA</a></li> <li><a href="/wiki/PDGFRB" title="PDGFRB">PDGFRB</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">FGFR2</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/VEGF_receptors" class="mw-redirect" title="VEGF receptors">VEGF receptors</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FLT1" class="mw-redirect" title="FLT1">VEGFR1</a></li> <li><a href="/wiki/Kinase_insert_domain_receptor" title="Kinase insert domain receptor">VEGFR2</a></li> <li><a href="/wiki/VEGFR3" class="mw-redirect" title="VEGFR3">VEGFR3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/C-Met" class="mw-redirect" title="C-Met">HGF receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C-Met" class="mw-redirect" title="C-Met">MET</a></li> <li><a href="/wiki/MST1R" title="MST1R">RON</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Trk_receptor" title="Trk receptor">Trk receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">NTRK1</a></li> <li><a href="/wiki/NTRK2" class="mw-redirect" title="NTRK2">NTRK2</a></li> <li><a href="/wiki/NTRK3" class="mw-redirect" title="NTRK3">NTRK3</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ephrin_receptor" title="Ephrin receptor">EPH receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EPH_receptor_A1" title="EPH receptor A1">EPHA1</a></li> <li><a href="/wiki/EPH_receptor_A2" title="EPH receptor A2">EPHA2</a></li> <li><a href="/wiki/EPH_receptor_A3" title="EPH receptor A3">EPHA3</a></li> <li><a href="/wiki/EPH_receptor_A4" title="EPH receptor A4">EPHA4</a></li> <li><a href="/wiki/EPH_receptor_A5" title="EPH receptor A5">EPHA5</a></li> <li><a href="/wiki/EPHA6" title="EPHA6">EPHA6</a></li> <li><a href="/wiki/EPHA7" title="EPHA7">EPHA7</a></li> <li><a href="/wiki/EPHA8" title="EPHA8">EPHA8</a></li> <li><a href="/wiki/EPH_receptor_B1" title="EPH receptor B1">EPHB1</a></li> <li><a href="/wiki/EPH_receptor_B2" title="EPH receptor B2">EPHB2</a></li> <li><a href="/wiki/EPHB3" title="EPHB3">EPHB3</a></li> <li><a href="/wiki/EPH_receptor_B4" title="EPH receptor B4">EPHB4</a></li> <li><a href="/w/index.php?title=EPHB5&action=edit&redlink=1" class="new" title="EPHB5 (page does not exist)">EPHB5</a></li> <li><a href="/wiki/EPHB6" title="EPHB6">EPHB6</a></li> <li><a href="/w/index.php?title=EPHX&action=edit&redlink=1" class="new" title="EPHX (page does not exist)">EPHX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leukocyte_receptor_tyrosine_kinase" title="Leukocyte receptor tyrosine kinase">LTK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leukocyte_receptor_tyrosine_kinase" title="Leukocyte receptor tyrosine kinase">LTK</a></li> <li><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">ALK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Angiopoietin_receptor" title="Angiopoietin receptor">TIE receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TIE1" title="TIE1">TIE</a></li> <li><a href="/wiki/TEK_tyrosine_kinase" title="TEK tyrosine kinase">TEK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_tyrosine_kinase-like_orphan_receptor" title="Receptor tyrosine kinase-like orphan receptor">ROR receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ROR1" title="ROR1">ROR1</a></li> <li><a href="/wiki/ROR2" title="ROR2">ROR2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/DDR1" title="DDR1">DDR receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DDR1" title="DDR1">DDR1</a></li> <li><a href="/wiki/Discoidin_domain-containing_receptor_2" title="Discoidin domain-containing receptor 2">DDR2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/PTK7" title="PTK7">PTK7 receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PTK7" title="PTK7">PTK7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Related_to_receptor_tyrosine_kinase" title="Related to receptor tyrosine kinase">RYK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Related_to_receptor_tyrosine_kinase" title="Related to receptor tyrosine kinase">RYK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/MuSK_protein" title="MuSK protein">MuSK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MuSK_protein" title="MuSK protein">MUSK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">ROS receptor family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ROS1" title="ROS1">ROS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/AATK" title="AATK">AATYK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AATK" title="AATK">AATYK</a></li> <li><a href="/wiki/LMTK2" title="LMTK2">AATYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/AXL_receptor_tyrosine_kinase" title="AXL receptor tyrosine kinase">AXL receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AXL_receptor_tyrosine_kinase" title="AXL receptor tyrosine kinase">AXL</a></li> <li><a href="/wiki/MERTK" title="MERTK">MER</a></li> <li><a href="/wiki/TYRO3" title="TYRO3">TYRO3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">uncategorised</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STYK1" title="STYK1">STYK1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Non-receptor_tyrosine_kinases_(EC_2.7.10.2)82" style="font-size:114%;margin:0 4em"><a href="/wiki/Non-receptor_tyrosine_kinase" title="Non-receptor tyrosine kinase">Non-receptor tyrosine kinases</a> (EC 2.7.10.2)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/ABL_(gene)" title="ABL (gene)">ABL</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abl_gene" class="mw-redirect" title="Abl gene">ABL1</a></li> <li><a href="/wiki/ABL2" title="ABL2">ARG</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TNK2" title="TNK2">ACK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TNK2" title="TNK2">ACK1</a></li> <li><a href="/w/index.php?title=TNK1&action=edit&redlink=1" class="new" title="TNK1 (page does not exist)">TNK1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine-protein_kinase_CSK" title="Tyrosine-protein kinase CSK">CSK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C-src_tyrosine_kinase" class="mw-redirect" title="C-src tyrosine kinase">CSK</a></li> <li><a href="/wiki/Megakaryocyte-associated_tyrosine_kinase" title="Megakaryocyte-associated tyrosine kinase">MATK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/PTK2" title="PTK2">FAK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PTK2" title="PTK2">FAK</a></li> <li><a href="/wiki/PTK2B" title="PTK2B">PYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Feline_sarcoma_oncogene" class="mw-redirect" title="Feline sarcoma oncogene">FES</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Feline_sarcoma_oncogene" class="mw-redirect" title="Feline sarcoma oncogene">FES</a></li> <li><a href="/wiki/FER_(gene)" title="FER (gene)">FER</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fyn-related_kinase" title="Fyn-related kinase">FRK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fyn-related_kinase" title="Fyn-related kinase">FRK</a></li> <li><a href="/wiki/PTK6" title="PTK6">BRK</a></li> <li><a href="/w/index.php?title=SRMS_(gene)&action=edit&redlink=1" class="new" title="SRMS (gene) (page does not exist)">SRMS</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Janus_kinase_1" title="Janus kinase 1">JAK1</a></li> <li><a href="/wiki/Janus_kinase_2" title="Janus kinase 2">JAK2</a></li> <li><a href="/wiki/Janus_kinase_3" title="Janus kinase 3">JAK3</a></li> <li><a href="/wiki/Tyrosine_kinase_2" title="Tyrosine kinase 2">TYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">SRC-A family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Proto-oncogene_tyrosine-protein_kinase_Src" title="Proto-oncogene tyrosine-protein kinase Src">SRC</a></li> <li><a href="/wiki/FGR_(gene)" title="FGR (gene)">FGR</a></li> <li><a href="/wiki/FYN" title="FYN">FYN</a></li> <li><a href="/wiki/YES1" class="mw-redirect" title="YES1">YES1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">SRC-B family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosine-protein_kinase_BLK" title="Tyrosine-protein kinase BLK">BLK</a></li> <li><a class="mw-selflink selflink">HCK</a></li> <li><a href="/wiki/Lck" class="mw-redirect" title="Lck">LCK</a></li> <li><a href="/wiki/LYN" title="LYN">LYN</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TEC_(gene)" title="TEC (gene)">TEC</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TEC_(gene)" title="TEC (gene)">TEC</a></li> <li><a href="/wiki/BMX_(gene)" title="BMX (gene)">BMX</a></li> <li><a href="/wiki/Bruton%27s_tyrosine_kinase" title="Bruton's tyrosine kinase">BTK</a></li> <li><a href="/wiki/ITK_(gene)" title="ITK (gene)">ITK</a></li> <li><a href="/wiki/TXK_(gene)" title="TXK (gene)">TXK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine-protein_kinase_SYK" title="Tyrosine-protein kinase SYK">SYK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosine-protein_kinase_SYK" title="Tyrosine-protein kinase SYK">SYK</a></li> <li><a href="/wiki/ZAP-70" class="mw-redirect" title="ZAP-70">ZAP70</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Enzymes56" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes56" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a 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