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For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions" /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Relation" content="10.1136/bmj.i5191" /> <meta name="DC.Relation" content="10.1136/bmj.39489.470347.AD" /> <meta name="DC.Relation" content="10.1136/bmj.q2269" /> <meta name="DC.Relation" content="10.1136/bmj.q2605" /> <meta name="DC.Relation" content="10.1136/bmj.q2605" /> <meta name="DC.Description" content="Clinical question What is the impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on survival and on cardiovascular and kidney outcomes for adults living with chronic kidney disease (CKD)? Current practice Few therapies slow kidney disease progression and improve long term prognosis for adults living with CKD. SGLT-2 inhibitors have demonstrated cardiovascular and kidney benefits in adults with CKD with and without type 2 diabetes. Existing guidance for SGLT-2 inhibitors does not account for the totality of current best evidence for adults with CKD and does not provide fully stratified treatment effects and recommendations across all risk groups based on risk of CKD progression and complications. Recommendations The guideline panel considered evidence regarding benefits and harms of SGLT-2 inhibitor therapy for adults with CKD over a five year period, along with contextual factors, and provided the following recommendations: 1. For adults at low risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour) 2. For adults at moderate risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour) 3. For adults at high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour) 4. For adults at very high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour). Recommendations are applicable to all adults with CKD, irrespective of type 2 diabetes status. How this guideline was created An international panel including patients, clinicians, and methodologists produced these recommendations following standards for trustworthy guidelines and using the GRADE approach. The panel identified typical risk strata of adults with CKD (from low to very high risk of CKD progression and related complications) using the classification system developed by Kidney Disease Improving Global Outcomes (KDIGO), and applied an individual patient perspective in moving from evidence to recommendations. Effects of SGLT-2 inhibitors were interpreted in absolute terms applicable to different risk strata with varying baseline risks for outcomes of benefit over a five year period. The panel explicitly considered the balance of benefits, harms, and burdens of starting an SGLT-2 inhibitor, incorporating the values and preferences of adults with different risk profiles. Interactive evidence summaries and decision aids accompany multilayered recommendations, developed in an online authoring and publication platform ([www.magicapp.org][1]) that allows reuse and adaptation. The evidence A linked systematic review and pairwise meta-analysis (13 trials including 29 614 participants) of benefits and harms associated with SGLT-2 inhibitors in adults with CKD with or without type 2 diabetes informed guidance. Among individuals at very high risk of CKD progression and complications, moderate to high certainty evidence shows SGLT-2 inhibitors (relative to placebo or standard care without SGLT-2 inhibitors) decrease all-cause and cardiovascular mortality, hospitalisation for heart failure, kidney failure, non-fatal myocardial infarction, and non-fatal stroke. Among individuals at high risk, moderate to high certainty evidence shows SGLT-2 inhibitors result in similar benefits across outcomes except demonstrating little or no effect on hospitalisation for heart failure and kidney failure. Among individuals at moderate and low risk, moderate to high certainty evidence shows SGLT-2 inhibitors probably reduce all-cause mortality and non-fatal stroke, with little or no effect for other outcomes of benefit. Risk-stratified estimates were unavailable for outcomes of harm; the panel therefore considered absolute effects summarised across risk strata. SGLT-2 inhibitors are associated with little or no effect on acute kidney injury requiring dialysis, bone fractures, lower limb amputations, ketoacidosis, genital infections, or symptomatic hypovolaemia, although a residual possibility of harms at the individual patient level remains. Understanding the recommendation In order to apply recommendations, clinicians must appropriately identify adults with CKD, consider the underlying aetiology, and risk stratify them based on glomerular filtration rate (estimated or measured) and degree of albuminuria. In addition to classifying individuals into risk strata, further estimation of a given patient’s risk based on the extent of their kidney disease and other comorbidities may be warranted to inform individual-level decisions and shared decision making. Available risk calculators may help estimate a given patient’s risk of CKD progression and complications. [1]: http://www.magicapp.org" /> <meta name="DC.Contributor" content="Arnav Agarwal" /> <meta name="DC.Contributor" content="Xiaoxi Zeng" /> <meta name="DC.Contributor" content="Sheyu Li" /> <meta name="DC.Contributor" content="Daniel Rayner" /> <meta name="DC.Contributor" content="Farid Foroutan" /> <meta name="DC.Contributor" content="Bert Aertgeerts" /> <meta name="DC.Contributor" content="Frederic Coyac" /> <meta name="DC.Contributor" content="Pauline Darbellay Farhoumand" /> <meta name="DC.Contributor" content="Andrew Demaine" /> <meta name="DC.Contributor" content="Anja Fog Heen" /> <meta name="DC.Contributor" content="Vivekanand Jha" /> <meta name="DC.Contributor" content="Edward Machuve" /> <meta name="DC.Contributor" content="Evi Nagler" /> <meta name="DC.Contributor" content="David J Tunnicliffe" /> <meta name="DC.Contributor" content="Gordon H Guyatt" /> <meta name="DC.Contributor" content="Per Olav Vandvik" /> <meta name="DC.Contributor" content="Belen Ponte" /> <meta name="DC.Contributor" content="Thomas Agoritsas" /> <meta name="article:published_time" content="2024-10-01" /> <meta name="article:section" content="Practice" /> <meta name="citation_title" content="Sodium-glucose cotransporter-2 (SGLT-2) inhibitors for adults with chronic kidney disease: a clinical practice guideline" /> <meta name="citation_abstract" lang="en" content="<h3>Abstract</h3> <h3>Clinical question</h3> <p>What is the impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on survival and on cardiovascular and kidneyoutcomes for adults living with chronic kidney disease (CKD)?</p><h3>Current practice</h3> <p>Few therapies slow kidney disease progression and improve long term prognosis for adults living with CKD. SGLT-2 inhibitors have demonstrated cardiovascular and kidney benefits in adults with CKD with and without type 2 diabetes. Existing guidance for SGLT-2 inhibitors does not account for the totality of current best evidence for adults with CKD and does not provide fully stratified treatment effects and recommendations across all risk groups based on risk of CKD progression and complications.</p><h3>Recommendations</h3> <p>The guideline panel considered evidence regarding benefits and harms of SGLT-2 inhibitor therapy for adults with CKD over a five year period, along with contextual factors, and provided the following recommendations:</p><p>1. For adults at low risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour)</p><p>2. For adults at moderate risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour)</p><p>3. For adults at high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour)</p><p>4. For adults at very high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour).</p><p>Recommendations are applicable to all adults with CKD, irrespective of type 2 diabetes status.</p><h3>How this guideline was created</h3> <p>An international panel including patients, clinicians, and methodologists produced these recommendations following standards for trustworthy guidelines and using the GRADE approach. The panel identified typical risk strata of adults with CKD (from low to very high risk of CKD progression and related complications) using the classification system developed by Kidney Disease Improving Global Outcomes (KDIGO), and applied an individual patient perspective in moving from evidence to recommendations. Effects of SGLT-2 inhibitors were interpreted in absolute terms applicable to different risk strata with varying baseline risks for outcomes of benefit over a five year period. The panel explicitly considered the balance of benefits, harms, and burdens of starting an SGLT-2 inhibitor, incorporating the values and preferences of adults with different risk profiles. Interactive evidence summaries and decision aids accompany multilayered recommendations, developed in an online authoring and publication platform (www.magicapp.org) that allows reuse and adaptation.</p><h3>The evidence</h3> <p>A linked systematic review and pairwise meta-analysis (13 trials including 29 614 participants) of benefits and harms associated with SGLT-2 inhibitors in adults with CKD with or without type 2 diabetes informed guidance. Among individuals at very high risk of CKD progression and complications, moderate to high certainty evidence shows SGLT-2 inhibitors (relative to placebo or standard care without SGLT-2 inhibitors) decrease all-cause and cardiovascular mortality, hospitalisation for heart failure, kidney failure, non-fatal myocardial infarction, and non-fatal stroke. Among individuals at high risk, moderate to high certainty evidence shows SGLT-2 inhibitors result in similar benefits across outcomes except demonstrating little or no effect on hospitalisation for heart failure and kidney failure. Among individuals at moderate and low risk, moderate to high certainty evidence shows SGLT-2 inhibitors probably reduce all-cause mortality and non-fatal stroke, with little or no effect for other outcomes of benefit. Risk-stratified estimates were unavailable for outcomes of harm; the panel therefore considered absolute effects summarised across risk strata. SGLT-2 inhibitors are associated with little or no effect on acute kidney injury requiring dialysis, bone fractures, lower limb amputations, ketoacidosis, genital infections, or symptomatic hypovolaemia, although a residual possibility of harms at the individual patient level remains.</p><h3>Understanding the recommendation</h3> <p>In order to apply recommendations, clinicians must appropriately identify adults with CKD, consider the underlying aetiology, and risk stratify them based on glomerular filtration rate (estimated or measured) and degree of albuminuria. In addition to classifying individuals into risk strata, further estimation of a given patient’s risk based on the extent of their kidney disease and other comorbidities may be warranted to inform individual-level decisions and shared decision making. Available risk calculators may help estimate a given patient’s risk of CKD progression and complications.</p>" /> <meta name="citation_journal_title" content="BMJ" /> <meta name="citation_publisher" content="British Medical Journal Publishing Group" /> <meta name="citation_publication_date" content="2024/10/01" /> <meta name="citation_mjid" content="bmj;387/oct01_4/e080257" /> <meta name="citation_id" content="387/oct01_4/e080257" /> <meta name="citation_public_url" content="https://www.bmj.com/content/387/bmj-2024-080257" /> <meta name="citation_abstract_html_url" content="https://www.bmj.com/content/387/bmj-2024-080257.abstract" /> <meta name="citation_full_html_url" content="https://www.bmj.com/content/387/bmj-2024-080257.full" /> <meta name="citation_pdf_url" content="https://www.bmj.com/content/bmj/387/bmj-2024-080257.full.pdf" /> <meta name="citation_issn" content="1756-1833" /> <meta name="citation_journal_abbrev" content="BMJ" /> <meta name="citation_doi" content="10.1136/bmj-2024-080257" /> <meta name="citation_pmid" content="39353639" /> <meta name="citation_volume" content="387" /> <meta name="citation_article_type" content="Other" /> <meta name="citation_section" content="Practice" /> <meta name="citation_author" content="Arnav Agarwal" /> <meta name="citation_author_institution" content="Department of Medicine, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5" /> <meta name="citation_author_institution" content="Department of Health Research Methods, Evidence and Impact, HSC 2C, Hamilton, Ontario, Canada, L8S 4L8" /> <meta name="citation_author_institution" content="MAGIC Evidence Ecosystem Foundation, Oslo, Norway, 0282" /> <meta name="citation_author_institution" content=". Both authors contributed equally (co-first authors)" /> <meta name="citation_author" content="Xiaoxi Zeng" /> <meta name="citation_author_institution" content="Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China, 610041" /> <meta name="citation_author_institution" content="MAGIC Evidence Ecosystem Foundation, Oslo, Norway, 0282" /> <meta name="citation_author_institution" content=". Both authors contributed equally (co-first authors)" /> <meta name="citation_author" content="Sheyu Li" /> <meta name="citation_author_institution" content="Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China, 610041" /> <meta name="citation_author_institution" content="Chinese Evidence-Based Medicine Center, Cochrane China Center and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China, 610041" /> <meta name="citation_author" content="Daniel Rayner" /> <meta name="citation_author_institution" content="Department of Health Research Methods, Evidence and Impact, HSC 2C, Hamilton, Ontario, Canada, L8S 4L8" /> <meta name="citation_author" content="Farid Foroutan" /> <meta name="citation_author_institution" content="Department of Health Research Methods, Evidence and Impact, HSC 2C, Hamilton, Ontario, Canada, L8S 4L8" /> <meta name="citation_author_institution" content="MAGIC Evidence Ecosystem Foundation, Oslo, Norway, 0282" /> <meta name="citation_author_institution" content="Ted Rogers Center for Heart Research, Toronto, Ontario, Canada, M5G 1X8" /> <meta name="citation_author" content="Bert Aertgeerts" /> <meta name="citation_author_institution" content="Academic Centre for General Practice, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium, 3000" /> <meta name="citation_author_institution" content="CEBAM, Belgian Centre for Evidence-Based Medicine, Cochrane Belgium, Leuven, Belgium, 3000." /> <meta name="citation_author" content="Frederic Coyac" /> <meta name="citation_author_institution" content="Geneva, Switzerland." /> <meta name="citation_author" content="Pauline Darbellay Farhoumand" /> <meta name="citation_author_institution" content="Division of General Internal Medicine, Department of Medicine, Hôpitaux Universitaire de Genève and University of Geneva, Geneva, Switzerland, 1205" /> <meta name="citation_author" content="Andrew Demaine" /> <meta name="citation_author_institution" content="Plymouth, United Kingdom." /> <meta name="citation_author" content="Anja Fog Heen" /> <meta name="citation_author_institution" content="MAGIC Evidence Ecosystem Foundation, Oslo, Norway, 0282" /> <meta name="citation_author_institution" content="Department of Medicine, Lovisenberg Diaconal Hospital, Oslo, Norway, 0456" /> <meta name="citation_author" content="Vivekanand Jha" /> <meta name="citation_author_institution" content="George Institute for Global Health, Elegance Tower, Jasola District Centre, New Delhi, India, 110025." /> <meta name="citation_author_institution" content="School of Public Health, Imperial College London, London, UK, SW7 2AZ" /> <meta name="citation_author_institution" content="Prasanna School of Public Health, Manipal Academy of Higher Education, Madhav Nagar, Eshwar Nagar, Manipal, Karnataka, India, 576104" /> <meta name="citation_author" content="Edward Machuve" /> <meta name="citation_author_institution" content="Geneva, Switzerland." /> <meta name="citation_author" content="Evi Nagler" /> <meta name="citation_author_institution" content="Department of Nephrology, Ghent University Hospital, Ghent, Belgium, 9000" /> <meta name="citation_author" content="David J Tunnicliffe" /> <meta name="citation_author_institution" content="Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia, 2006" /> <meta name="citation_author_institution" content="Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia, 2145" /> <meta name="citation_author" content="Gordon H Guyatt" /> <meta name="citation_author_institution" content="Department of Medicine, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5" /> <meta name="citation_author_institution" content="Department of Health Research Methods, Evidence and Impact, HSC 2C, Hamilton, Ontario, Canada, L8S 4L8" /> <meta name="citation_author_institution" content="MAGIC Evidence Ecosystem Foundation, Oslo, Norway, 0282" /> <meta name="citation_author" content="Per Olav Vandvik" /> <meta name="citation_author_institution" content="MAGIC Evidence Ecosystem Foundation, Oslo, Norway, 0282" /> <meta name="citation_author_institution" content="Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway, 2819" /> <meta name="citation_author" content="Belen Ponte" /> <meta name="citation_author_institution" content="Division of Nephrology and Hypertension, Department of Medicine, University of Geneva, University Hospitals of Geneva, Geneva, Switzerland, 1205" /> <meta name="citation_author_institution" content=". Both authors contributed equally (co-last authors)" /> <meta name="citation_author" content="Thomas Agoritsas" /> <meta name="citation_author_institution" content="Department of Health Research Methods, Evidence and Impact, HSC 2C, Hamilton, Ontario, Canada, L8S 4L8" /> <meta name="citation_author_institution" content="MAGIC Evidence Ecosystem Foundation, Oslo, Norway, 0282" /> <meta name="citation_author_institution" content="Division of General Internal Medicine, Department of Medicine, Hôpitaux Universitaire de Genève and University of Geneva, Geneva, Switzerland, 1205" /> <meta name="citation_author_institution" content=". 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Robertshaw;citation_title=Consensus recommendations for sick day medication guidance for people with diabetes, kidney, or cardiovascular disease: a modified Delphi process;citation_pages=564-74;citation_volume=81;citation_year=2023;citation_pmid=36470530;citation_doi=10.1053/j.ajkd.2022.10.012" /> <meta name="citation_reference" content="citation_journal_title=Kidney Int Rep;citation_author=K. Yau;citation_author=A. Dharia;citation_author=I. Alrowiyti;citation_author=DZI. Cherney;citation_title=Prescribing SGLT2 inhibitors in patients with CKD: expanding indications and practical considerations;citation_pages=1463-76;citation_volume=7;citation_year=2022;citation_pmid=35812300;citation_doi=10.1016/j.ekir.2022.04.094" /> <meta name="twitter:title" content="Sodium-glucose cotransporter-2 (SGLT-2) inhibitors for adults with chronic kidney disease: a clinical practice guideline" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:description" content="Clinical question What is the impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on survival and on cardiovascular and kidney outcomes for adults living with chronic kidney disease (CKD)? Current practice Few therapies slow kidney disease progression and improve long term prognosis for adults living with CKD. SGLT-2 inhibitors have demonstrated cardiovascular and kidney benefits in adults with CKD with and without type 2 diabetes. Existing guidance for SGLT-2 inhibitors does not account for the totality of current best evidence for adults with CKD and does not provide fully stratified treatment effects and recommendations across all risk groups based on risk of CKD progression and complications. Recommendations The guideline panel considered evidence regarding benefits and harms of SGLT-2 inhibitor therapy for adults with CKD over a five year period, along with contextual factors, and provided the following recommendations: 1. For adults at low risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour) 2. For adults at moderate risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour) 3. For adults at high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour) 4. For adults at very high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour). Recommendations are applicable to all adults with CKD, irrespective of type 2 diabetes status. How this guideline was created An international panel including patients, clinicians, and methodologists produced these recommendations following standards for trustworthy guidelines and using the GRADE approach. The panel identified typical risk strata of adults with CKD (from low to very high risk of CKD progression and related complications) using the classification system developed by Kidney Disease Improving Global Outcomes (KDIGO), and applied an individual patient perspective in moving from evidence to recommendations. Effects of SGLT-2 inhibitors were interpreted in absolute terms applicable to different risk strata with varying baseline risks for outcomes of benefit over a five year period. The panel explicitly considered the balance of benefits, harms, and burdens of starting an SGLT-2 inhibitor, incorporating the values and preferences of adults with different risk profiles. Interactive evidence summaries and decision aids accompany multilayered recommendations, developed in an online authoring and publication platform ([www.magicapp.org][1]) that allows reuse and adaptation. The evidence A linked systematic review and pairwise meta-analysis (13 trials including 29 614 participants) of benefits and harms associated with SGLT-2 inhibitors in adults with CKD with or without type 2 diabetes informed guidance. Among individuals at very high risk of CKD progression and complications, moderate to high certainty evidence shows SGLT-2 inhibitors (relative to placebo or standard care without SGLT-2 inhibitors) decrease all-cause and cardiovascular mortality, hospitalisation for heart failure, kidney failure, non-fatal myocardial infarction, and non-fatal stroke. Among individuals at high risk, moderate to high certainty evidence shows SGLT-2 inhibitors result in similar benefits across outcomes except demonstrating little or no effect on hospitalisation for heart failure and kidney failure. Among individuals at moderate and low risk, moderate to high certainty evidence shows SGLT-2 inhibitors probably reduce all-cause mortality and non-fatal stroke, with little or no effect for other outcomes of benefit. Risk-stratified estimates were unavailable for outcomes of harm; the panel therefore considered absolute effects summarised across risk strata. SGLT-2 inhibitors are associated with little or no effect on acute kidney injury requiring dialysis, bone fractures, lower limb amputations, ketoacidosis, genital infections, or symptomatic hypovolaemia, although a residual possibility of harms at the individual patient level remains. Understanding the recommendation In order to apply recommendations, clinicians must appropriately identify adults with CKD, consider the underlying aetiology, and risk stratify them based on glomerular filtration rate (estimated or measured) and degree of albuminuria. In addition to classifying individuals into risk strata, further estimation of a given patient’s risk based on the extent of their kidney disease and other comorbidities may be warranted to inform individual-level decisions and shared decision making. Available risk calculators may help estimate a given patient’s risk of CKD progression and complications. [1]: http://www.magicapp.org" /> <meta name="og-title" property="og:title" content="Sodium-glucose cotransporter-2 (SGLT-2) inhibitors for adults with chronic kidney disease: a clinical practice guideline" /> <meta name="og-url" property="og:url" content="https://www.bmj.com/content/387/bmj-2024-080257" /> <meta name="og-site-name" property="og:site_name" content="The BMJ" /> <meta name="og-description" property="og:description" content="Clinical question What is the impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on survival and on cardiovascular and kidney outcomes for adults living with chronic kidney disease (CKD)? Current practice Few therapies slow kidney disease progression and improve long term prognosis for adults living with CKD. SGLT-2 inhibitors have demonstrated cardiovascular and kidney benefits in adults with CKD with and without type 2 diabetes. Existing guidance for SGLT-2 inhibitors does not account for the totality of current best evidence for adults with CKD and does not provide fully stratified treatment effects and recommendations across all risk groups based on risk of CKD progression and complications. Recommendations The guideline panel considered evidence regarding benefits and harms of SGLT-2 inhibitor therapy for adults with CKD over a five year period, along with contextual factors, and provided the following recommendations: 1. For adults at low risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour) 2. For adults at moderate risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour) 3. For adults at high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour) 4. For adults at very high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour). Recommendations are applicable to all adults with CKD, irrespective of type 2 diabetes status. How this guideline was created An international panel including patients, clinicians, and methodologists produced these recommendations following standards for trustworthy guidelines and using the GRADE approach. The panel identified typical risk strata of adults with CKD (from low to very high risk of CKD progression and related complications) using the classification system developed by Kidney Disease Improving Global Outcomes (KDIGO), and applied an individual patient perspective in moving from evidence to recommendations. Effects of SGLT-2 inhibitors were interpreted in absolute terms applicable to different risk strata with varying baseline risks for outcomes of benefit over a five year period. The panel explicitly considered the balance of benefits, harms, and burdens of starting an SGLT-2 inhibitor, incorporating the values and preferences of adults with different risk profiles. Interactive evidence summaries and decision aids accompany multilayered recommendations, developed in an online authoring and publication platform ([www.magicapp.org][1]) that allows reuse and adaptation. The evidence A linked systematic review and pairwise meta-analysis (13 trials including 29 614 participants) of benefits and harms associated with SGLT-2 inhibitors in adults with CKD with or without type 2 diabetes informed guidance. Among individuals at very high risk of CKD progression and complications, moderate to high certainty evidence shows SGLT-2 inhibitors (relative to placebo or standard care without SGLT-2 inhibitors) decrease all-cause and cardiovascular mortality, hospitalisation for heart failure, kidney failure, non-fatal myocardial infarction, and non-fatal stroke. Among individuals at high risk, moderate to high certainty evidence shows SGLT-2 inhibitors result in similar benefits across outcomes except demonstrating little or no effect on hospitalisation for heart failure and kidney failure. Among individuals at moderate and low risk, moderate to high certainty evidence shows SGLT-2 inhibitors probably reduce all-cause mortality and non-fatal stroke, with little or no effect for other outcomes of benefit. Risk-stratified estimates were unavailable for outcomes of harm; the panel therefore considered absolute effects summarised across risk strata. SGLT-2 inhibitors are associated with little or no effect on acute kidney injury requiring dialysis, bone fractures, lower limb amputations, ketoacidosis, genital infections, or symptomatic hypovolaemia, although a residual possibility of harms at the individual patient level remains. Understanding the recommendation In order to apply recommendations, clinicians must appropriately identify adults with CKD, consider the underlying aetiology, and risk stratify them based on glomerular filtration rate (estimated or measured) and degree of albuminuria. In addition to classifying individuals into risk strata, further estimation of a given patient’s risk based on the extent of their kidney disease and other comorbidities may be warranted to inform individual-level decisions and shared decision making. Available risk calculators may help estimate a given patient’s risk of CKD progression and complications. 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href="/us/education">Education</a></li> <li>Sodium-glucose...</li> <li class="active last">Sodium-glucose cotransporter-2 (SGLT-2) inhibitors for adults with chronic kidney disease: a clinical practice guideline</li> </ol> <a id="main-content"></a> <div class="region region-content"> <section id="block-system-main" class="block block-system clearfix"> <div class="panel-display" > <div class="hero"> <div class="hero-wrapper"> <div class="hero-content" style="position: relative; left: 0px; top: 35.5px;"> </div>  </div>  </div>  <div class="row"> <div class="left-content col-xs-12 col-sm-8 col-md-8 col-lg-8"> <article> <div class="panel-pane pane-highwire-article-citation" > <div class="pane-content"> <div class="highwire-article-citation highwire-citation-type-highwire-article node1101485" data-node-nid="1101485" id="node-1101485--2318824931" data-pisa="bmj;387/oct01_4/e080257" data-pisa-master="bmj;bmj-2024-080257" data-apath="/bmj/387/bmj-2024-080257.atom"><cite class='highwire-cite 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class="scaling-svg" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 750 50" enable-background="new 0 0 750 50" xml:space="preserve"> <g id="visSumTitle" transform="translate(190,0)"> <g> <text transform="matrix(1 0 0 1 58.2085 30.2236)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="20.3891px">Visual summary of recommendation</text> </g> <g> <path fill="#FFFFFF" d="M48.739,23.664c0,0-8.202,10.645-18.32,10.645s-18.32-10.645-18.32-10.645s8.202-10.645,18.32-10.645 S48.739,23.664,48.739,23.664z"></path> <g> <g> <g> <path fill="#407DC0" d="M30.434,23.402l-4.21-7.921c1.351-0.719,2.679-1.05,4.21-1.05V23.402z"></path> </g> </g> <g> <g> <path fill="#799BD1" d="M30.434,23.402l-5.52-7.069c0.414-0.323,0.847-0.605,1.311-0.852L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#628ECA" d="M30.434,23.402l-7.434-5.017c0.562-0.834,1.121-1.434,1.913-2.053L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#006AB3" d="M30.434,23.402l-8.661-2.322c0.26-0.972,0.665-1.861,1.227-2.695L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#4981C2" d="M30.434,23.402l-7.604,4.754c-1.396-2.235-1.739-4.53-1.057-7.076L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#7498CF" d="M30.434,23.402l-5.52,7.069c-0.855-0.668-1.509-1.395-2.084-2.315L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#437FC1" d="M30.434,23.402l4.347,7.846c-3.209,1.78-6.976,1.483-9.868-0.777L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#7297CF" d="M30.434,23.402l8.661,2.322c-0.655,2.446-2.101,4.297-4.314,5.524L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#1E72B9" d="M30.434,23.402l8.933,0.782c-0.047,0.538-0.132,1.018-0.271,1.54L30.434,23.402z"></path> </g> </g> <path fill="#6F95CE" d="M39.379,22.776c-0.01-0.143-0.028-0.325-0.045-0.467l-8.9,1.093l8.933,0.782 C39.413,23.656,39.416,23.305,39.379,22.776z"></path> <g> <g> <path fill="#3A7BBF" d="M30.434,23.402l7.254-5.273c0.926,1.275,1.454,2.616,1.646,4.18L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#006AB3" d="M30.434,23.402l4.071-7.993c1.324,0.675,2.31,1.518,3.183,2.72L30.434,23.402z"></path> </g> </g> <g> <g> <path fill="#006AB3" d="M30.434,23.402v-8.971c1.52,0,2.716,0.287,4.071,0.978L30.434,23.402z"></path> </g> </g> </g> <circle cx="30.419" cy="23.416" r="5.457"></circle> <g> <path fill="#FFFFFF" d="M36.82,14.387c-1.023-0.421-2.085-0.764-3.186-0.999l-2.773,9.319L36.82,14.387z"></path> </g> </g> </g> </svg> </div> </div> <div id="image0"><div class="whiteBox" style="margin:15px; background-color: #FFF; border-radius: 12px;"><div class="scaling-svg-container" style="padding-bottom: 105.51468005283273%; margin: 0px auto 0px auto;"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" id="Layer_1" version="1.1" viewBox="0 0 695 733.327">  <rect x="140.246" y="478.42" width="541.744" height="238.769" rx="6.258" ry="6.258" fill="#ccc"></rect> <rect x="348.102" y="257.716" width="328.195" height="85.017" rx="11.831" ry="11.831" fill="#ccc"></rect> <g> <text transform="translate(55.103 32.917)" fill="#2f6eb5" font-family="InterFace-Bold, InterFace" font-size="21" font-weight="700" isolation="isolate"><tspan x="0" y="0">Population</tspan></text> <g> <g> <path d="M20.755,16.884c0-1.688,1.397-3.055,3.12-3.055s3.12,1.367,3.12,3.055-1.397,3.055-3.12,3.055c-1.723,0-3.12-1.368-3.12-3.055Z" fill="#2f6eb5"></path> <path d="M24.039,20.823h-.328c-2.176,0-3.941.456-3.941,3.859v2.211c0,1.476.532,2.298,1.369,2.74l.603,6.894h4.187l.601-6.863c.884-.44,1.45-1.271,1.45-2.772v-2.211c0-3.457-1.764-3.858-3.941-3.858Z" fill="#2f6eb5"></path> </g> <g> <path d="M30.56,14.027c0-1.933,1.6-3.499,3.573-3.499s3.574,1.566,3.574,3.499-1.6,3.499-3.574,3.499c-1.973,0-3.573-1.567-3.573-3.499Z" fill="#2f6eb5"></path> <path d="M34.321,18.538h-.376c-2.493,0-4.514.522-4.514,4.42v2.533c0,1.691.609,2.632,1.569,3.139l.691,7.897h4.796l.688-7.861c1.013-.504,1.661-1.456,1.661-3.175v-2.533c0-3.959-2.022-4.42-4.515-4.42Z" fill="#2f6eb5"></path> </g> <g> <path d="M41.185,18.622c0-1.538,1.273-2.785,2.844-2.785s2.844,1.246,2.844,2.785-1.273,2.785-2.844,2.785-2.844-1.247-2.844-2.785Z" fill="#2f6eb5"></path> <path d="M44.178,22.213h-.299c-1.984,0-3.592.416-3.592,3.517v2.016c0,1.345.485,2.094,1.248,2.498l.55,6.284h3.816l.547-6.255c.806-.401,1.322-1.159,1.322-2.526v-2.017c0-3.151-1.608-3.517-3.592-3.517Z" fill="#2f6eb5"></path> </g> </g> </g> <text transform="translate(18.804 56.359)" font-family="InterFace-Bold, InterFace" font-size="16" font-weight="700" isolation="isolate"><tspan x="0" y="0">Recommendations apply to:</tspan></text> <g> <path 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d="M78.276,115.622l-.108-.702c-.312.324-.651.556-1.017.693s-.765.207-1.197.207c-.612,0-1.155-.117-1.629-.352-.474-.233-.873-.555-1.197-.963-.324-.407-.57-.891-.738-1.449-.168-.558-.252-1.16-.252-1.809,0-.552.087-1.095.261-1.629s.432-1.008.774-1.422c.342-.414.771-.747,1.287-.999s1.116-.378,1.8-.378c.432,0,.804.033,1.116.099.312.066.576.142.792.226v-3.528h1.386v12.006h-1.278ZM78.168,108.35c-.072-.047-.171-.096-.297-.144s-.267-.093-.423-.135c-.156-.042-.318-.075-.486-.1-.168-.023-.33-.035-.486-.035-.504,0-.942.096-1.314.287-.372.192-.681.447-.927.766s-.429.681-.549,1.089c-.12.408-.18.822-.18,1.242,0,.479.054.927.162,1.341s.273.771.495,1.071c.222.3.498.537.828.711.33.174.723.261,1.179.261.36,0,.714-.075,1.062-.225.348-.15.66-.399.936-.747v-5.383Z" fill="#fff"></path> <path d="M81.984,115.622v-8.586h1.278l.09.684c.348-.264.759-.479,1.233-.647s.969-.252,1.485-.252c1.176,0,2.007.291,2.493.873.486.582.729,1.442.729,2.583v5.346h-1.386v-5.382c0-.72-.162-1.284-.486-1.692-.324-.407-.853-.611-1.584-.611-.457,0-.903.099-1.341.297-.438.197-.813.417-1.125.656v6.732h-1.386Z" fill="#fff"></path> <path 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d="M100.074,117.89c.132.048.297.093.495.136.198.042.399.062.603.062.276,0,.492-.065.648-.198.156-.132.318-.39.486-.773l.702-1.71-3.384-8.37h1.584l2.538,6.605,2.538-6.605h1.494l-4.392,10.854c-.216.528-.52.889-.909,1.08-.39.192-.795.288-1.215.288-.276,0-.567-.039-.873-.117-.306-.078-.543-.152-.711-.225l.396-1.026Z" fill="#fff"></path> <path d="M118.343,115.622l-.108-.702c-.312.324-.651.556-1.017.693s-.765.207-1.197.207c-.612,0-1.155-.117-1.629-.352-.474-.233-.873-.555-1.197-.963-.324-.407-.57-.891-.738-1.449-.168-.558-.252-1.16-.252-1.809,0-.552.087-1.095.261-1.629s.432-1.008.774-1.422c.342-.414.771-.747,1.287-.999s1.116-.378,1.8-.378c.432,0,.804.033,1.116.099.312.066.576.142.792.226v-3.528h1.386v12.006h-1.278ZM118.235,108.35c-.072-.047-.171-.096-.297-.144s-.267-.093-.423-.135c-.156-.042-.318-.075-.486-.1-.168-.023-.33-.035-.486-.035-.504,0-.942.096-1.314.287-.372.192-.681.447-.927.766s-.429.681-.549,1.089c-.12.408-.18.822-.18,1.242,0,.479.054.927.162,1.341s.273.771.495,1.071c.222.3.498.537.828.711.33.174.723.261,1.179.261.36,0,.714-.075,1.062-.225.348-.15.66-.399.936-.747v-5.383Z" fill="#fff"></path> <path 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d="M126.407,113.498c.204.384.465.682.783.891.318.211.747.315,1.287.315,1.176,0,1.764-.42,1.764-1.26,0-.252-.039-.465-.117-.64-.078-.174-.204-.329-.378-.468-.174-.138-.399-.27-.675-.396-.276-.126-.612-.262-1.008-.405-.432-.145-.798-.297-1.098-.459-.3-.162-.546-.339-.738-.531-.192-.191-.333-.407-.423-.647s-.135-.522-.135-.847c0-.695.255-1.241.765-1.638.51-.396,1.185-.594,2.025-.594.696,0,1.278.117,1.746.351.468.234.864.567,1.188.999l-.972.774c-.24-.288-.522-.528-.846-.721-.324-.191-.69-.287-1.098-.287-.504,0-.879.099-1.125.297-.246.197-.369.44-.369.729,0,.18.033.339.099.478.066.138.183.264.351.378s.387.228.657.342.615.243,1.035.387c.792.276,1.392.624,1.8,1.044.408.421.612.979.612,1.674,0,.408-.078.771-.234,1.09-.156.317-.369.585-.639.801s-.591.381-.963.495c-.372.113-.78.171-1.224.171-.852,0-1.518-.156-1.998-.468-.48-.312-.864-.708-1.152-1.188l1.08-.666Z" fill="#fff"></path> <path d="M134.309,111.248c0,1.08.246,1.926.738,2.538.492.612,1.206.918,2.142.918.54,0,.996-.132,1.368-.396.372-.264.672-.587.9-.972l.918.612c-.312.54-.717.987-1.215,1.341s-1.167.531-2.007.531c-.648,0-1.23-.1-1.746-.297-.516-.198-.957-.486-1.323-.864-.366-.378-.648-.849-.846-1.413-.198-.563-.297-1.218-.297-1.962,0-.685.093-1.299.279-1.845s.444-1.015.774-1.404.732-.69,1.206-.9.999-.314,1.575-.314c.636,0,1.191.107,1.665.324.474.216.867.519,1.179.908.312.391.546.858.702,1.404.156.546.234,1.143.234,1.791h-6.246ZM138.989,110.15c-.012-.372-.084-.699-.216-.981-.132-.281-.3-.516-.504-.702-.204-.186-.438-.323-.702-.414-.264-.09-.528-.135-.792-.135-.576,0-1.071.171-1.485.513-.414.343-.699.916-.855,1.72h4.554Z" fill="#fff"></path> <path d="M147.269,115.622l-.072-.738c-.3.301-.645.531-1.035.693-.39.162-.819.243-1.287.243-.372,0-.735-.058-1.089-.171-.354-.114-.666-.282-.936-.504-.27-.223-.489-.501-.657-.838-.168-.335-.252-.726-.252-1.17,0-.611.165-1.115.495-1.512.33-.396.747-.711,1.251-.945.504-.233,1.062-.398,1.674-.494.612-.097,1.206-.145,1.782-.145v-.108c0-.72-.153-1.235-.459-1.548-.306-.312-.747-.468-1.323-.468-.396,0-.759.087-1.089.261-.331.175-.609.405-.837.693l-.972-.684c.348-.469.759-.813,1.233-1.035s1.071-.333,1.791-.333c.96,0,1.707.246,2.241.737.534.492.801,1.314.801,2.467v5.598h-1.26ZM147.143,111.14c-.396.013-.816.043-1.26.091s-.855.141-1.233.278c-.378.139-.69.34-.936.604-.246.264-.369.611-.369,1.044,0,.276.054.51.162.702.108.191.243.351.405.477.162.126.342.216.54.271.198.054.393.081.585.081.42,0,.807-.087,1.161-.262.354-.174.669-.381.945-.621v-2.664Z" fill="#fff"></path> <path d="M151.427,113.498c.204.384.465.682.783.891.318.211.747.315,1.287.315,1.176,0,1.764-.42,1.764-1.26,0-.252-.039-.465-.117-.64-.078-.174-.204-.329-.378-.468-.174-.138-.399-.27-.675-.396-.276-.126-.612-.262-1.008-.405-.432-.145-.798-.297-1.098-.459-.3-.162-.546-.339-.738-.531-.192-.191-.333-.407-.423-.647s-.135-.522-.135-.847c0-.695.255-1.241.765-1.638.51-.396,1.185-.594,2.025-.594.696,0,1.278.117,1.746.351.468.234.864.567,1.188.999l-.972.774c-.24-.288-.522-.528-.846-.721-.324-.191-.69-.287-1.098-.287-.504,0-.879.099-1.125.297-.246.197-.369.44-.369.729,0,.18.033.339.099.478.066.138.183.264.351.378s.387.228.657.342.615.243,1.035.387c.792.276,1.392.624,1.8,1.044.408.421.612.979.612,1.674,0,.408-.078.771-.234,1.09-.156.317-.369.585-.639.801s-.591.381-.963.495c-.372.113-.78.171-1.224.171-.852,0-1.518-.156-1.998-.468-.48-.312-.864-.708-1.152-1.188l1.08-.666Z" fill="#fff"></path> <path d="M159.328,111.248c0,1.08.246,1.926.738,2.538.492.612,1.206.918,2.142.918.54,0,.996-.132,1.368-.396.372-.264.672-.587.9-.972l.918.612c-.312.54-.717.987-1.215,1.341s-1.167.531-2.007.531c-.648,0-1.23-.1-1.746-.297-.516-.198-.957-.486-1.323-.864-.366-.378-.648-.849-.846-1.413-.198-.563-.297-1.218-.297-1.962,0-.685.093-1.299.279-1.845s.444-1.015.774-1.404.732-.69,1.206-.9.999-.314,1.575-.314c.636,0,1.191.107,1.665.324.474.216.867.519,1.179.908.312.391.546.858.702,1.404.156.546.234,1.143.234,1.791h-6.246ZM164.008,110.15c-.012-.372-.084-.699-.216-.981-.132-.281-.3-.516-.504-.702-.204-.186-.438-.323-.702-.414-.264-.09-.528-.135-.792-.135-.576,0-1.071.171-1.485.513-.414.343-.699.916-.855,1.72h4.554Z" fill="#fff"></path> </g> <rect x="203.903" y="78.008" width="120.742" height="41.445" rx="8.9" ry="8.9" fill="#d1c8e4"></rect> <text transform="translate(217.54 95.205)" font-family="InterFace-Regular, InterFace" font-size="14" isolation="isolate"><tspan x="0" y="0">With or without </tspan><tspan x="19.236" y="16.8">diabetes</tspan></text> <g> <ellipse cx="520.227" cy="113.012" rx="135.129" ry="88.164" fill="#fbdace"></ellipse> <image width="282" height="201" transform="translate(400 30.963) scale(.842)" xlink:href="https://sandpit.bmj.com/site_images/2024/ckd3.png"></image> </g> </g> <text transform="translate(18.804 161.282)" font-family="InterFace-Bold, InterFace" font-size="16" font-weight="700"><tspan x="0" y="0">Recommendations may or may not apply to:</tspan></text> <text transform="translate(18.804 355.977)" font-family="InterFace-Bold, InterFace" font-size="16" font-weight="700"><tspan x="0" y="0">Risk stratification for recommendations:</tspan></text> <g> <path d="M318.679,188.395H48.211c-5.667,0-10.302-4.64-10.302-10.303s4.636-10.301,10.302-10.301h270.467c5.667,0,10.302,4.637,10.302,10.301.001,5.663-4.635,10.303-10.301,10.303Z" fill="#ee7219"></path> <text transform="translate(60.478 182.308)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="14"><tspan x="0" y="0">People receiving kidney replacement therapy</tspan></text> <g> <path d="M47.53,182.487c0-.268.049-.511.149-.743.099-.243.237-.448.413-.613.176-.193.382-.32.619-.423.236-.09.487-.143.75-.143s.514.053.75.143c.237.103.442.23.619.423.176.165.314.37.413.613.099.233.149.475.149.743,0,.27-.051.513-.149.756-.098.233-.237.45-.413.616-.176.18-.382.308-.619.41s-.487.153-.75.153-.515-.05-.75-.153c-.237-.103-.443-.23-.619-.41-.175-.165-.313-.383-.413-.616-.1-.243-.149-.485-.149-.756Z" fill="#fff"></path> <path d="M48.536,176.774c.297,0,.577-.04.841-.128.264-.078.492-.193.685-.335.192-.14.343-.32.453-.523.109-.205.165-.438.165-.668,0-.333-.11-.613-.331-.858-.22-.243-.517-.358-.891-.358-.341,0-.614.115-.816.333-.123.14-.208.308-.257.501-.061.243-.267.41-.515.41h-2.339c-.249,0-.451-.193-.451-.45,0-.255.168-.793.312-1.089.226-.46.538-.871.94-1.229.401-.333.874-.616,1.419-.796.544-.193,1.135-.295,1.773-.295.649,0,1.24.118,1.773.32.533.218.992.513,1.377.873.385.358.682.768.891,1.254.209.475.313.948.313,1.462,0,1.654-.996,2.818-2.985,3.524v.731c0,.255-.202.448-.451.448h-2.134c-.249,0-.451-.193-.451-.448v-2.23c.001-.255.203-.448.452-.448h.227Z" fill="#fff"></path> </g> </g> <g> <path d="M349.018,214.066H75.55c-5.667,0-10.302-4.64-10.302-10.303s4.636-10.301,10.302-10.301h273.467c5.667,0,10.302,4.637,10.302,10.301.001,5.663-4.635,10.303-10.301,10.303Z" fill="#ee7219"></path> <text transform="translate(87.818 207.979)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="14"><tspan x="0" y="0">People who have received a kidney transplant</tspan></text> <g> <path d="M74.869,208.158c0-.268.049-.511.149-.743.099-.243.237-.448.413-.613.176-.193.382-.32.619-.423.236-.09.487-.143.75-.143s.514.053.75.143c.237.103.442.23.619.423.176.165.314.37.413.613.099.233.149.475.149.743,0,.27-.051.513-.149.756-.098.233-.237.45-.413.616-.176.18-.382.308-.619.41s-.487.153-.75.153-.515-.05-.75-.153c-.237-.103-.443-.23-.619-.41-.175-.165-.313-.383-.413-.616-.1-.243-.149-.485-.149-.756Z" fill="#fff"></path> <path d="M75.876,202.444c.297,0,.577-.04.841-.128.264-.078.492-.193.685-.335.192-.14.343-.32.453-.523.109-.205.165-.438.165-.668,0-.333-.11-.613-.331-.858-.22-.243-.517-.358-.891-.358-.341,0-.614.115-.816.333-.123.14-.208.308-.257.501-.061.243-.267.41-.515.41h-2.339c-.249,0-.451-.193-.451-.45,0-.255.168-.793.312-1.089.226-.46.538-.871.94-1.229.401-.333.874-.616,1.419-.796.544-.193,1.135-.295,1.773-.295.649,0,1.24.118,1.773.32.533.218.992.513,1.377.873.385.358.682.768.891,1.254.209.475.313.948.313,1.462,0,1.654-.996,2.818-2.985,3.524v.731c0,.255-.202.448-.451.448h-2.134c-.249,0-.451-.193-.451-.448v-2.23c.001-.255.203-.448.452-.448h.227Z" fill="#fff"></path> </g> </g> <g> <path d="M255.574,241.088H29.106c-5.667,0-10.302-4.64-10.302-10.303s4.636-10.301,10.302-10.301h226.467c5.667,0,10.302,4.637,10.302,10.301.001,5.663-4.635,10.303-10.301,10.303Z" fill="#ee7219"></path> <text transform="translate(41.373 235.001)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="14"><tspan x="0" y="0">People with polycystic kidney disease</tspan></text> <g> <path d="M28.425,235.18c0-.268.049-.511.149-.743.099-.243.237-.448.413-.613.176-.193.382-.32.619-.423.236-.09.487-.143.75-.143s.514.053.75.143c.237.103.442.23.619.423.176.165.314.37.413.613.099.233.149.475.149.743,0,.27-.051.513-.149.756-.098.233-.237.45-.413.616-.176.18-.382.308-.619.41s-.487.153-.75.153-.515-.05-.75-.153c-.237-.103-.443-.23-.619-.41-.175-.165-.313-.383-.413-.616-.1-.243-.149-.485-.149-.756Z" fill="#fff"></path> <path 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stroke-miterlimit="10"></path> <text transform="translate(51.987 619.807)" font-family="InterFace-Regular, InterFace"><tspan font-size="18"><tspan x="0" y="0">3-30</tspan></tspan><tspan font-size="14"><tspan x="-12.302" y="16.8">mg/mmol</tspan></tspan></text> </g> <text></text> <g> <path d="M149.878,545.89c0-3.186,2.802-5.77,6.258-5.77h106.405c3.456,0,6.258,2.583,6.258,5.77v35.711c0,3.186-2.802,5.77-6.258,5.77h-106.405c-3.456,0-6.258-2.583-6.258-5.77v-35.711Z" fill="#006ab3" stroke="#fff" stroke-miterlimit="10"></path> <text transform="translate(194.156 561.504)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="18"><tspan x="0" y="0">Low</tspan></text> <text transform="translate(160.566 577.75)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="12"><tspan x="0" y="0">Recommendation 1</tspan></text> </g> <g> <path 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transform="translate(309.504 680.919)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="18"><tspan x="0" y="0">Very high</tspan></text> <text transform="translate(295.398 696.332)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="12"><tspan x="0" y="0">Recommendation 4</tspan></text> </g> <g> <path d="M554.376,545.89c0-3.186,2.802-5.77,6.258-5.77h106.405c3.456,0,6.258,2.583,6.258,5.77v35.711c0,3.186-2.802,5.77-6.258,5.77h-106.405c-3.456,0-6.258-2.583-6.258-5.77v-35.711Z" fill="#e11f21" stroke="#fff" stroke-miterlimit="10"></path> <text transform="translate(579.17 561.504)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="18"><tspan x="0" y="0">Very high</tspan></text> <text transform="translate(565.063 577.75)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="12"><tspan x="0" y="0">Recommendation 4</tspan></text> </g> <g> <path 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fill="#fff" stroke="#fff" stroke-miterlimit="10"></path> <text transform="translate(52.16 680.086)" font-family="InterFace-Regular, InterFace"><tspan font-size="17"><tspan x="0" y="0">> 30 </tspan></tspan><tspan font-size="14"><tspan x="-12.475" y="16.8">mg/mmol</tspan></tspan></text> </g> <g> <rect x="228.592" y="489.218" width="365.052" height="26.669" rx="6.258" ry="6.258" fill="#333"></rect> <text transform="translate(246.809 505.563)" fill="#fff" font-family="InterFace-Bold, InterFace" font-size="14" font-weight="700"><tspan x="0" y="0">Risk of kidney disease progression and complications</tspan></text> </g> <g> <rect x="299.015" y="372.6" width="224.206" height="26.669" rx="5.579" ry="5.579" fill="#333"></rect> <text transform="translate(318.642 388.946)" fill="#fff" font-size="14"><tspan x="0" y="0" xml:space="preserve" font-family="InterFace-Bold, InterFace" font-weight="700">GFR </tspan><tspan x="44.602" y="0" font-family="InterFace-Regular, InterFace">Glomerular filtration rate</tspan></text> </g> </svg></div></div></div><div id="image1"><div class="whiteBox" style="margin:15px; background-color: #FFF; border-radius: 12px;"><div class="scaling-svg-container" style="padding-bottom: 35.868058238955705%; margin: 0px auto 0px auto;"><svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" version="1.1" viewBox="0 0 695 249.283"> <rect x="234.964" y="53.556" width="411.097" height="172.874" rx="11.856" ry="11.856" fill="#6f4f9b" stroke-width="0"></rect> <g> <text transform="translate(51.066 37.167)" fill="#2f6eb5" font-family="InterFace-Bold, InterFace" font-size="21" font-weight="700" isolation="isolate"><tspan x="0" y="0">Interventions compared</tspan></text> <path 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d="M601.123,153.031c0,.841.191,1.498.574,1.975.383.476.938.714,1.666.714.42,0,.774-.103,1.063-.309.289-.205.522-.457.7-.756l.714.477c-.242.42-.558.768-.944,1.043-.388.275-.908.413-1.562.413-.504,0-.957-.077-1.358-.231s-.744-.378-1.028-.672c-.285-.294-.504-.66-.658-1.099s-.231-.947-.231-1.526c0-.532.072-1.01.218-1.435.145-.425.345-.789.602-1.093.257-.303.569-.536.938-.699.368-.164.776-.245,1.225-.245.494,0,.926.084,1.295.252s.674.403.917.707c.243.303.425.667.546,1.092s.183.889.183,1.393h-4.858ZM604.763,152.178c-.009-.289-.065-.544-.168-.763-.103-.22-.233-.401-.392-.547-.159-.145-.341-.252-.546-.321-.206-.07-.411-.105-.616-.105-.448,0-.833.133-1.155.399-.321.266-.544.712-.665,1.337h3.542Z" fill="#fff" stroke-width="0"></path> <path 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d="M615.641,154.907c0,.327.063.544.189.651s.287.161.483.161c.177,0,.345-.037.504-.112.158-.074.303-.163.434-.266l.42.728c-.215.159-.427.285-.637.378-.21.094-.507.141-.889.141-.505,0-.892-.129-1.162-.386-.271-.256-.406-.65-.406-1.183v-4.382h-1.148v-.882h1.148v-1.82h1.078v1.82h1.75v.882h-1.765v4.27Z" fill="#fff" stroke-width="0"></path> <path d="M619.085,154.781c.158.299.361.53.609.693.247.163.58.245,1.001.245.914,0,1.371-.327,1.371-.98,0-.195-.03-.361-.091-.497-.061-.135-.158-.256-.294-.363-.135-.107-.311-.21-.524-.309-.215-.098-.477-.203-.784-.314-.336-.112-.621-.231-.854-.357s-.425-.264-.573-.413c-.149-.149-.26-.317-.329-.504-.07-.187-.105-.406-.105-.658,0-.541.198-.966.595-1.273.397-.309.922-.462,1.575-.462.541,0,.994.091,1.358.272.364.183.672.441.924.777l-.756.602c-.187-.224-.406-.41-.658-.56s-.537-.224-.854-.224c-.393,0-.685.076-.875.23-.191.154-.287.343-.287.567,0,.14.025.264.077.371.051.107.142.205.272.294s.301.177.511.266.479.189.806.301c.615.215,1.082.485,1.399.812.317.326.477.761.477,1.302,0,.317-.062.6-.183.847-.121.248-.287.455-.497.623s-.459.297-.749.386c-.289.088-.606.133-.951.133-.663,0-1.182-.122-1.555-.364s-.672-.551-.896-.924l.84-.519Z" fill="#fff" stroke-width="0"></path> </g> <text transform="translate(250.025 181.135)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="14"><tspan x="0" y="0">Medications:</tspan></text> <text transform="translate(30.953 106.033)" fill="#fff" font-family="InterFace-Regular, InterFace" font-size="14"><tspan x="0" y="0">Usual care without </tspan><tspan x="0" y="16.8">SGLT-2 inhibitors </tspan></text> <g> <rect x="250.502" y="190.46" width="95.354" height="21.081" rx="10.541" ry="10.541" fill="#fff" stroke-width="0"></rect> <text transform="translate(258.933 204.852)" fill="#000" font-family="InterFace-Regular, InterFace" font-size="14"><tspan x="0" y="0">Empagliflozin</tspan></text> </g> <g> <rect x="352.614" y="190.46" width="91.708" height="21.081" rx="10.541" ry="10.541" fill="#fff" stroke-width="0"></rect> <text transform="translate(361.045 204.852)" fill="#000" font-family="InterFace-Regular, InterFace" font-size="14"><tspan x="0" y="0">Dapagliflozin</tspan></text> </g> <g> <rect x="451.432" y="190.46" width="91.708" height="21.081" rx="10.541" ry="10.541" fill="#fff" stroke-width="0"></rect> <text transform="translate(459.863 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class="scaling-svg-container" style="padding-bottom: 24.89208633093525%; max-width: 695px; margin: 0px auto 0px auto"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 695 173" enable-background="0 0 695 173" xml:space="preserve" style="width: 100%;"><path fill="#D8DBDF" d="M34.5,0 h626 a20,20 0 0 1 20,20 v120 a20,20 0 0 1 -20,20 h-626 a20,20 0 0 1 -20,-20 v-120 a20,20 0 0 1 20,-20"></path><path fill="#00B2A9" d="M34.5,0 h313 v90 h-333 v-70 a20,20 0 0 1 20,-20"></path><path fill="#765FA8" d="M347.5,0 h313 a20,20 0 0 1 20,20 v70 h-333 z"></path><text transform="matrix(1 0 0 1 184 28)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="18px" text-anchor="middle">No SGLT-2 inhibitors</text><text transform="matrix(1 0 0 1 511 28)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="18px" text-anchor="middle">SGLT-2 inhibitors</text><line fill="none" stroke="#FFFFFF" stroke-width="3" stroke-miterlimit="10" x1="347.5" y1="0" x2="347.5" y2="90"></line><circle fill="#FFFFFF" cx="347.776" cy="46.175" r="15.575"></circle><text transform="matrix(1 0 0 1 339.7538 50.7762)" font-family="'InterFace-Regular'" font-size="18px">or</text><g transform="translate(0,-10.598800000000011)"><path fill="#FFFFFF" d="M252.351,158.478H42.009c-8.182,0-14.876-6.694-14.876-14.876v-23.514c0-4.28,3.502-7.781,7.781-7.781h217.438c4.28,0,7.781,3.502,7.781,7.781v30.609C260.132,154.976,256.631,158.478,252.351,158.478z"></path><g transform="translate(0,0)"><path fill="#7C8696" d="M36.955,126.089c0-1.686,1.395-3.052,3.116-3.052c1.721,0,3.117,1.366,3.117,3.052c0,1.685-1.396,3.052-3.117,3.052C38.351,129.141,36.955,127.774,36.955,126.089z"></path><path fill="#7C8696" d="M40.236,130.024h-0.328c-2.174,0-3.936,0.456-3.936,3.855v2.209c0,1.474,0.531,2.295,1.368,2.737l0.602,6.887h4.182l0.6-6.855c0.883-0.439,1.449-1.27,1.449-2.769v-2.209C44.173,130.425,42.41,130.024,40.236,130.024z"></path><path fill="#7C8696" d="M46.749,124.235c0-1.931,1.598-3.496,3.57-3.496c1.971,0,3.57,1.565,3.57,3.496c0,1.93-1.599,3.496-3.57,3.496C48.347,127.731,46.749,126.166,46.749,124.235z"></path><path fill="#7C8696" d="M50.507,128.742h-0.376c-2.49,0-4.509,0.522-4.509,4.415v2.53c0,1.689,0.609,2.629,1.567,3.136l0.69,7.888h4.791l0.687-7.852c1.012-0.503,1.659-1.455,1.659-3.171v-2.53C55.016,129.202,52.997,128.742,50.507,128.742z"></path><path fill="#7C8696" d="M57.363,126.826c0-1.537,1.272-2.782,2.84-2.782c1.569,0,2.841,1.245,2.841,2.782c0,1.536-1.272,2.782-2.841,2.782C58.634,129.608,57.363,128.362,57.363,126.826z"></path><path fill="#7C8696" d="M60.353,130.412h-0.299c-1.982,0-3.588,0.415-3.588,3.514v2.013c0,1.344,0.484,2.092,1.247,2.495l0.549,6.277h3.812l0.547-6.248c0.805-0.4,1.32-1.157,1.32-2.524v-2.013C63.941,130.778,62.334,130.412,60.353,130.412z"></path></g><text transform="matrix(1 0 0 1 74.466 138.498)" font-family="'InterFace-Regular'" font-size="14px">Low risk</text></g><g transform="translate(0,-10.598800000000011)"><path fill="#FFFFFF" d="M276.914,158.478h375.71c8.182,0,14.876-6.694,14.876-14.876v-23.514c0-4.28-3.502-7.781-7.781-7.781H276.914c-4.28,0-7.781,3.502-7.781,7.781v30.609C269.132,154.976,272.634,158.478,276.914,158.478z"></path><path fill="#7C8696" d="M277.498,123.473c1.013-1.118,2.563-1.802,4.651-2.052c0.822-0.099,1.548,0.492,1.548,1.225v1.42c0,0.521-0.365,1.008-0.929,1.159c-0.667,0.179-1.158,0.473-1.474,0.881c-0.449,0.581-0.673,1.452-0.673,2.613v0.522h1.682c0.77,0,1.393,0.551,1.393,1.231v5.9c0,0.68-0.624,1.231-1.393,1.231h-5.286c-0.77,0-1.393-0.551-1.393-1.231v-6.608C275.624,126.95,276.249,124.852,277.498,123.473z M289.724,119.879c1.271-1.402,3.215-2.26,5.834-2.574c1.032-0.124,1.942,0.617,1.942,1.537v1.782c0,0.654-0.457,1.264-1.165,1.454c-0.836,0.224-1.452,0.593-1.848,1.106c-0.563,0.729-0.844,1.821-0.844,3.278v0.655h2.11c0.965,0,1.748,0.691,1.748,1.544v7.401c0,0.853-0.783,1.544-1.748,1.544h-6.631c-0.965,0-1.748-0.691-1.748-1.544v-8.288C287.374,124.24,288.157,121.609,289.724,119.879z"></path><path fill="#7C8696" d="M657.626,145.424c-1.013,1.118-2.563,1.802-4.651,2.052c-0.822,0.099-1.548-0.492-1.548-1.225v-1.42c0-0.521,0.365-1.008,0.929-1.159c0.667-0.179,1.158-0.473,1.474-0.882c0.449-0.581,0.673-1.452,0.673-2.613v-0.522h-1.682c-0.77,0-1.393-0.551-1.393-1.231v-5.9c0-0.68,0.624-1.231,1.393-1.231h5.286c0.77,0,1.393,0.551,1.393,1.231v6.608C659.5,141.947,658.875,144.045,657.626,145.424z M645.4,149.018c-1.271,1.402-3.215,2.26-5.834,2.574c-1.032,0.124-1.942-0.617-1.942-1.537v-1.782c0-0.654,0.457-1.264,1.166-1.454c0.836-0.224,1.452-0.593,1.848-1.106c0.563-0.729,0.844-1.821,0.844-3.278v-0.655h-2.11c-0.965,0-1.748-0.691-1.748-1.544v-7.401c0-0.853,0.783-1.544,1.748-1.544h6.631c0.965,0,1.748,0.691,1.748,1.544v8.288C647.751,144.657,646.967,147.289,645.4,149.018z"></path><text transform="matrix(1 0 0 1 467.816 138.6864)" font-family="'InterFace-Regular'" font-size="14px" text-anchor="middle">We suggest administering SGLT-2 inhibitors</text></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="164.011,117.552 66.011,117.552 56.011,102.552 66.011,87.552 164.011,87.552 154.011,102.552"></polygon><text transform="matrix(1 0 0 1 84.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Strong</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="160.139" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M160.648,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L160.648,91.629z M160.896,87.026c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C161.774,86.635,161.382,87.026,160.896,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M251.153,185.394h-229.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h108.9l6-6l6,6h109.001c3.2,0,5.5,2.6,5.5,5.7v45.754C256.653,183.194,254.353,185.394,251.153,185.394z"></path><text transform="matrix(1 0 0 1 24.9805 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">All or nearly all informed people would likely</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">want the intervention to the left. Benefits</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">would outweigh harms for almost everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="274.011,117.552 176.011,117.552 166.011,102.552 176.011,87.552 274.011,87.552 264.011,102.552"></polygon><text transform="matrix(1 0 0 1 198.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Weak</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="271.472" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M271.981,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.041,0.436c-0.465,0.243-0.898,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.548-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.578,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L271.981,91.629z M272.229,87.026c-0.476,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.476,0,0.857,0.403,0.857,0.891C273.107,86.635,272.715,87.026,272.229,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M348.293,185.394h-244.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h115.9l6-6l6,6h117.001c3.2,0,5.5,2.6,5.5,5.7v45.754C353.793,183.194,351.493,185.394,348.293,185.394z"></path><text transform="matrix(1 0 0 1 107.1205 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">Most people would likely want the intervention</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">to the left. Benefits would outweigh harms for</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the majority, but not for everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="1" fill="#FFFFFF" points="390.511,117.552 488.511,117.552 498.511,102.552 488.511,87.552 390.511,87.552 400.511,102.552"></polygon><text transform="matrix(1 0 0 1 425.6487 107.8645)" fill="#7D5CC6" font-family="'InterFace-Bold'" font-size="18px">Weak</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="487.595" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M488.104,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L488.104,91.629z M488.352,87.026c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C489.23,86.635,488.838,87.026,488.352,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M573.214,185.394h-244.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h115.9l6-6l6,6h117.001c3.2,0,5.5,2.6,5.5,5.7v45.754C578.714,183.194,576.413,185.394,573.214,185.394z"></path><text transform="matrix(1 0 0 1 332.041 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">Most people would likely want the intervention</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">to the right. Benefits would outweigh harms</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">for the majority, but not for everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="500.511,117.552 598.511,117.552 608.511,102.552 598.511,87.552 500.511,87.552 510.511,102.552"></polygon><text transform="matrix(1 0 0 1 530.6486 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Strong</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="597.928" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M598.437,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.041,0.436c-0.465,0.243-0.898,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.548-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.578,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L598.437,91.629z M598.685,87.026c-0.476,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.476,0,0.857,0.403,0.857,0.891C599.563,86.635,599.171,87.026,598.685,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M649.787,185.394h-231.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h107.9l6-6l6,6h112.001c3.2,0,5.5,2.6,5.5,5.7v45.754C655.287,183.194,652.987,185.394,649.787,185.394z"></path><text transform="matrix(1 0 0 1 421.6153 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">All or nearly all informed people would likely</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">want the intervention to the right. Benefits</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">would outweigh harms for almost everyone</tspan></text></g></g></svg></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 315.4078 21.7755)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Rationale</text><circle fill="#FFFFFF" cx="298.537" cy="16.747" r="10.974"></circle><path fill="#2A6EBB" d="M297.269,19.248v-0.967c0-0.307,0.05-0.605,0.149-0.896s0.226-0.563,0.38-0.816c0.153-0.253,0.318-0.487,0.494-0.702c0.176-0.214,0.341-0.398,0.495-0.552c0.215-0.229,0.433-0.444,0.656-0.644c0.222-0.199,0.421-0.406,0.598-0.621s0.322-0.438,0.437-0.667c0.115-0.23,0.173-0.491,0.173-0.782c0-0.536-0.161-0.95-0.483-1.242c-0.322-0.291-0.782-0.437-1.38-0.437c-0.445,0-0.889,0.126-1.334,0.379s-0.913,0.748-1.403,1.483l-2.208-1.472c0.537-0.843,1.223-1.533,2.059-2.07c0.835-0.536,1.859-0.805,3.07-0.805c1.533,0,2.703,0.384,3.507,1.15c0.805,0.767,1.208,1.802,1.208,3.104c0,0.384-0.057,0.736-0.172,1.059c-0.115,0.321-0.265,0.629-0.449,0.92c-0.184,0.291-0.391,0.563-0.621,0.816s-0.46,0.494-0.69,0.725c-0.399,0.429-0.759,0.839-1.081,1.23c-0.322,0.391-0.483,0.809-0.483,1.253v0.553H297.269z M297.959,24.192c-0.215-0.092-0.406-0.226-0.575-0.402c-0.169-0.176-0.299-0.376-0.391-0.598c-0.092-0.223-0.138-0.456-0.138-0.702c0-0.245,0.046-0.479,0.138-0.701c0.092-0.222,0.222-0.418,0.391-0.587c0.168-0.168,0.364-0.306,0.586-0.413c0.222-0.107,0.472-0.161,0.748-0.161c0.552,0,1.004,0.188,1.357,0.563c0.353,0.376,0.529,0.809,0.529,1.299c0,0.491-0.176,0.924-0.529,1.3c-0.353,0.376-0.805,0.563-1.357,0.563C298.442,24.354,298.189,24.3,297.959,24.192z"></path></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 14.144144144144144%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 94.2" enable-background="0 0 666 94.2" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 109.7213 21.7755)" font-family="'InterFace-Regular'" font-size="14px">Moderate certainty of small but important reductions in risks of</text><text transform="matrix(1 0 0 1 109.7213 38.575500000000005)" font-family="'InterFace-Regular'" font-size="14px">all-cause mortality and non-fatal stroke, balanced against moderate</text><text transform="matrix(1 0 0 1 109.7213 55.3755)" font-family="'InterFace-Regular'" font-size="14px">certainty of no important increase in the risk of harms led to a weak</text><text transform="matrix(1 0 0 1 109.7213 72.1755)" font-family="'InterFace-Regular'" font-size="14px">recommendation in favour of treatment</text></svg></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Potential benefits</text></svg></div></h2><div class="pane-content" style="padding: 0px 0px 10px 0px; max-width: 666px; margin: 0px auto 0px auto;"><div style="clear: both;"></div><div class="scaling-svg-container" style="padding-bottom: 11.562%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 60" enable-background="0 0 666 60" xml:space="preserve" style="width: 100%;"><polygon fill="#00B2A9" points="256.718,43.109 66.888,43.109 54.888,30.943 66.888,18.776 256.718,18.776 243.718,30.943"></polygon><text transform="matrix(1 0 0 1 157.389 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No SGLT-2 inhibitors</text><polygon fill="#765FA8" points="407.721,18.776 597.551,18.776 609.551,30.943 597.551,43.109 407.721,43.109 419.721,30.943"></polygon><text transform="matrix(1 0 0 1 511.128 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">SGLT-2 inhibitors</text><g class="thishasatooltip"><polygon fill="#7C8696" points="403.351,43.109 260.522,43.109 248.522,30.943 260.522,18.776 403.351,18.776 415.351,30.943"></polygon><text transform="matrix(1 0 0 1 332.32 34.4258)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No important difference</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="395.241" cy="18.088" r="6"></circle><path fill="#FFFFFF" d="M395.751,20.48c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L395.751,20.48z M395.999,15.877c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C396.877,15.486,396.484,15.877,395.999,15.877z"></path><g transform="matrix(1 0 0 1 365 5)" class="thisisthetooltip"><path opacity="0.8" enable-background="new " d="M-349.979,51.675c-5.6,0-10.1-4.5-10.1-10.1V10.211c0-5.6,4.5-10.1,10.1-10.1H11.135c5.6,0,10.1,4.5,10.1,10.1v5.2l10,10l-10,10v6.264c0,5.6-4.5,10.1-10.1,10.1L-349.979,51.675z"></path><text transform="matrix(1 0 0 1 -353.0981 16.7624)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">The panel found that this difference was not important for most patients,</tspan><tspan x="0" y="13" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">because the intervention effects were negligible and/or very imprecise, for</tspan><tspan x="0" y="26" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">example confidence intervals that include both important benefit and harm</tspan></text></g></g></svg></div><div class="scaling-svg-container" style="padding-bottom: 3.003%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 20" enable-background="0 0 666 20" xml:space="preserve" style="width: 100%;"><text transform="matrix(0.9746 0 0 1 14.0746 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Benefits</text><path fill="none" stroke="#7C8696" stroke-miterlimit="10" d="M441.083,17.13c0,0,0-1.791,0-3.98s-2.122-3.98-4.716-3.98H189.049c-2.594,0-4.716,1.791-4.716,3.98s0,3.98,0,3.98"></path><rect x="210.591642578125" y="5" fill="#C1D3E9" width="204.03271484375" height="8"></rect><text transform="matrix(0.9746 0 0 1 312.608 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">Events per 1000 people over 5 years</text><text transform="matrix(0.9746 0 0 1 488.304 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Evidence quality</text></svg></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">All-cause mortality</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">7 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">44</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">37</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="271.0919494628906" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 28 981 patients in 11 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">all-cause mortality</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" stroke="#FFFFFF" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Cardiovascular mortality</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">11</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">9</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 27 429 patients in 7 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors have little or no</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">effect on cardiovascular death</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-309.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-309.8,69-310,68.9-309.9,68.7z"></path><path fill="#FFFFFF" d="M-201,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-200.9,69-201.1,68.9-201,68.7z"></path><path fill="#FFFFFF" d="M-190.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-190,69-190.3,68.9-190.2,68.7z"></path><path fill="#FFFFFF" d="M-179.4,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-179.2,69-179.4,68.9-179.4,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Kidney failure</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">1</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">1</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 28 221 patients in 9 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors have little or no</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">effect on kidney failure</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Non-fatal myocardial infarction</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">61</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">46</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 16 049 patients in 4 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably have little</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">or no effect on non-fatal myocardial</tspan><tspan x="0" y="29.492" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">infarction</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Non-fatal stroke</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">10 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">38</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">28</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 16 049 patients in 4 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">non-fatal stroke</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" stroke="#FFFFFF" stroke-miterlimit="10" x1="-213.5" y1="59.9" x2="-213.5" y2="126.4"></line><line fill="none" stroke="#FFFFFF" stroke-miterlimit="10" x1="-66.5" y1="59.9" x2="-66.5" y2="126.4"></line><line fill="none" stroke="#FFFFFF" stroke-miterlimit="10" x1="78" y1="59.9" x2="78" y2="126.4"></line><path fill="#FFFFFF" d="M-342.4,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-342.3,69-342.5,68.9-342.4,68.7z"></path><path fill="#FFFFFF" d="M-331.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-331.4,69-331.7,68.9-331.6,68.7z"></path><path fill="#FFFFFF" d="M-320.8,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-320.6,69-320.8,68.9-320.8,68.7z"></path><path fill="#FFFFFF" d="M-309.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-309.8,69-310,68.9-309.9,68.7z"></path><path fill="#FFFFFF" d="M-201,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-200.9,69-201.1,68.9-201,68.7z"></path><path fill="#FFFFFF" d="M-190.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-190,69-190.3,68.9-190.2,68.7z"></path><path fill="#FFFFFF" d="M-179.4,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-179.2,69-179.4,68.9-179.4,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Admission for heart failure</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">14</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">10</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 26 962 patients in 6 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors have little or no</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">effect on hospital admission for heart</tspan><tspan x="0" y="29.492" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">failure</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path 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font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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font-size="12.2883px">Patient decision aids</text><circle fill="#057482" cx="9.6" cy="8.867" r="6.9"></circle><polygon fill="#FFFFFF" points="7.687,12.367 7.687,5.267 13.887,8.767 "></polygon><g transform="translate(19.108840942382812,-17.15)"><rect x="174.277" y="20.171" fill="#057482" width="20.823" height="11.301"></rect><path fill="#057482" 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d="M181.393,27.772c0,0-0.682,0.37-1.974,0.37c-0.893,0-1.782-0.543-1.782-1.534c0-0.576,0.187-1.612,2.019-1.612h0.389V24.84c0-0.184-0.025-0.326-0.117-0.423c-0.092-0.097-0.242-0.147-0.481-0.147c-0.273,0-0.526,0.019-0.758,0.061c-0.128,0.022-0.259,0.05-0.387,0.081c-0.056,0.014-0.162,0.028-0.162,0.042v-1.081c0,0,0.023-0.005,0.034-0.008c0.038-0.008,0.078-0.017,0.12-0.022c0.122-0.023,0.248-0.045,0.378-0.064c0.128-0.017,0.262-0.033,0.401-0.042c0.133-0.008,0.262-0.014,0.376-0.014c0.406,0,0.734,0.033,0.983,0.1c0.248,0.067,0.445,0.17,0.582,0.309s0.24,0.317,0.287,0.532c0.047,0.217,0.091,0.47,0.091,0.762L181.393,27.772L181.393,27.772z M178.748,26.606c0,0.365,0.301,0.565,0.699,0.565c0.376,0,0.585-0.095,0.593-0.1l0.005-0.012v-1.041c0,0-0.342-0.044-0.579-0.044C179.063,25.974,178.748,26.193,178.748,26.606z"></path><path fill="#FFFFFF" d="M191.45,26.7c-0.078,0.359-0.209,0.648-0.385,0.866c-0.175,0.22-0.409,0.376-0.699,0.468c-0.289,0.095-0.642,0.139-1.06,0.139h-0.173c-0.058,0-0.114-0.003-0.172-0.008v1.562h-1.281v-6.002c0,0,0.632-0.541,2.323-0.541c0.262,0,0.492,0.036,0.692,0.112c0.198,0.072,0.362,0.195,0.491,0.362c0.127,0.167,0.225,0.39,0.289,0.668s0.098,0.629,0.098,1.047C191.572,25.898,191.53,26.341,191.45,26.7z M190.141,24.509c-0.05-0.086-0.111-0.147-0.19-0.178c-0.076-0.034-0.173-0.048-0.289-0.048c-0.211,0-0.701,0.095-0.701,0.268v2.505c0.07,0.006,0.142,0.012,0.211,0.014c0.07,0.006,0.14,0.006,0.203,0.006c0.178,0,0.326-0.02,0.443-0.064c0.114-0.039,0.206-0.12,0.273-0.239c0.069-0.12,0.114-0.284,0.142-0.493c0.025-0.206,0.039-0.479,0.039-0.813c0-0.242-0.011-0.443-0.03-0.596C190.222,24.715,190.189,24.596,190.141,24.509z"></path></g></svg></div></a><div class="scaling-svg-container" style="padding-bottom: 5.045045045045046%; max-width: 666px; margin: 15px auto 0px auto; clear: both;"><svg version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 33.6" enable-background="0 0 666 33.6" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 15.0713 20.0906)" fill="#000000" font-family="'InterFace-Regular'" font-size="14px">See below for summary of harms</text></svg></div><div style="clear:both;"></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Individual considerations</text></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 22.16216216216216%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 147.6" enable-background="0 0 666 147.6" xml:space="preserve" style="width: 100%;"><rect fill="#FFFFFF" x="16.5" y="16.471" width="633" height="125.6" rx="12" ry="12"></rect><path fill="#2A6EBB" d="M16.5,46.419V28.471c0-6.6,5.4-12,12-12h609c6.6,0,12,5.4,12,12v17.948"></path><text transform="matrix(1 0 0 1 333 36)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Values and preferences</text><text transform="matrix(1 0 0 1 125 70)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">The panel inferred that the majority of individuals would be inclined to receive</text><text transform="matrix(1 0 0 1 125 84.4)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">SGLT-2 inhibitors, though acknowledged that a substantial proportion may be</text><text transform="matrix(1 0 0 1 125 98.80000000000001)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">disinclined to do so when faced with marginal benefits, increased pill burden,</text><text transform="matrix(1 0 0 1 125 113.20000000000002)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">medication costs and a residual risk of harms</text></svg></div></div></div></div></div><div class="whiteBox" style="margin:15px; padding:10px; background-color: #FFF; border-radius: 12px;"><div class="scaling-svg-container" style="padding-bottom: 11.223%; max-width: 695px; margin: 0px auto 0px auto"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 695 78" enable-background="0 0 695 78" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 55.1034 36.7349)" fill="#333333" font-family="'InterFace-Bold'" font-size="21px">Recommendation 2</text><path fill="#7C8696" d="M33.809,20.915c-7.32,0-13.254,3.258-13.254,7.277c0,2.436,2.187,4.586,5.534,5.907l-1.029,7.434l6.421-6.183c0.757,0.074,1.533,0.119,2.328,0.119c7.32,0,13.254-3.258,13.254-7.277S41.129,20.915,33.809,20.915z"></path></svg></div><div class="scaling-svg-container" style="padding-bottom: 24.89208633093525%; max-width: 695px; margin: 0px auto 0px auto"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 695 173" enable-background="0 0 695 173" xml:space="preserve" style="width: 100%;"><path fill="#D8DBDF" d="M34.5,0 h626 a20,20 0 0 1 20,20 v120 a20,20 0 0 1 -20,20 h-626 a20,20 0 0 1 -20,-20 v-120 a20,20 0 0 1 20,-20"></path><path fill="#00B2A9" d="M34.5,0 h313 v90 h-333 v-70 a20,20 0 0 1 20,-20"></path><path fill="#765FA8" d="M347.5,0 h313 a20,20 0 0 1 20,20 v70 h-333 z"></path><text transform="matrix(1 0 0 1 184 28)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="18px" text-anchor="middle">No SGLT-2 inhibitors</text><text transform="matrix(1 0 0 1 511 28)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="18px" text-anchor="middle">SGLT-2 inhibitors</text><line fill="none" stroke="#FFFFFF" stroke-width="3" stroke-miterlimit="10" x1="347.5" y1="0" x2="347.5" y2="90"></line><circle fill="#FFFFFF" cx="347.776" cy="46.175" r="15.575"></circle><text transform="matrix(1 0 0 1 339.7538 50.7762)" font-family="'InterFace-Regular'" font-size="18px">or</text><g transform="translate(0,-10.598800000000011)"><path fill="#FFFFFF" d="M252.351,158.478H42.009c-8.182,0-14.876-6.694-14.876-14.876v-23.514c0-4.28,3.502-7.781,7.781-7.781h217.438c4.28,0,7.781,3.502,7.781,7.781v30.609C260.132,154.976,256.631,158.478,252.351,158.478z"></path><g transform="translate(0,0)"><path fill="#7C8696" d="M36.955,126.089c0-1.686,1.395-3.052,3.116-3.052c1.721,0,3.117,1.366,3.117,3.052c0,1.685-1.396,3.052-3.117,3.052C38.351,129.141,36.955,127.774,36.955,126.089z"></path><path fill="#7C8696" d="M40.236,130.024h-0.328c-2.174,0-3.936,0.456-3.936,3.855v2.209c0,1.474,0.531,2.295,1.368,2.737l0.602,6.887h4.182l0.6-6.855c0.883-0.439,1.449-1.27,1.449-2.769v-2.209C44.173,130.425,42.41,130.024,40.236,130.024z"></path><path fill="#7C8696" d="M46.749,124.235c0-1.931,1.598-3.496,3.57-3.496c1.971,0,3.57,1.565,3.57,3.496c0,1.93-1.599,3.496-3.57,3.496C48.347,127.731,46.749,126.166,46.749,124.235z"></path><path fill="#7C8696" d="M50.507,128.742h-0.376c-2.49,0-4.509,0.522-4.509,4.415v2.53c0,1.689,0.609,2.629,1.567,3.136l0.69,7.888h4.791l0.687-7.852c1.012-0.503,1.659-1.455,1.659-3.171v-2.53C55.016,129.202,52.997,128.742,50.507,128.742z"></path><path fill="#7C8696" d="M57.363,126.826c0-1.537,1.272-2.782,2.84-2.782c1.569,0,2.841,1.245,2.841,2.782c0,1.536-1.272,2.782-2.841,2.782C58.634,129.608,57.363,128.362,57.363,126.826z"></path><path fill="#7C8696" d="M60.353,130.412h-0.299c-1.982,0-3.588,0.415-3.588,3.514v2.013c0,1.344,0.484,2.092,1.247,2.495l0.549,6.277h3.812l0.547-6.248c0.805-0.4,1.32-1.157,1.32-2.524v-2.013C63.941,130.778,62.334,130.412,60.353,130.412z"></path></g><text transform="matrix(1 0 0 1 74.466 138.498)" font-family="'InterFace-Regular'" font-size="14px">Moderate risk</text></g><g transform="translate(0,-10.598800000000011)"><path fill="#FFFFFF" d="M276.914,158.478h375.71c8.182,0,14.876-6.694,14.876-14.876v-23.514c0-4.28-3.502-7.781-7.781-7.781H276.914c-4.28,0-7.781,3.502-7.781,7.781v30.609C269.132,154.976,272.634,158.478,276.914,158.478z"></path><path fill="#7C8696" d="M277.498,123.473c1.013-1.118,2.563-1.802,4.651-2.052c0.822-0.099,1.548,0.492,1.548,1.225v1.42c0,0.521-0.365,1.008-0.929,1.159c-0.667,0.179-1.158,0.473-1.474,0.881c-0.449,0.581-0.673,1.452-0.673,2.613v0.522h1.682c0.77,0,1.393,0.551,1.393,1.231v5.9c0,0.68-0.624,1.231-1.393,1.231h-5.286c-0.77,0-1.393-0.551-1.393-1.231v-6.608C275.624,126.95,276.249,124.852,277.498,123.473z M289.724,119.879c1.271-1.402,3.215-2.26,5.834-2.574c1.032-0.124,1.942,0.617,1.942,1.537v1.782c0,0.654-0.457,1.264-1.165,1.454c-0.836,0.224-1.452,0.593-1.848,1.106c-0.563,0.729-0.844,1.821-0.844,3.278v0.655h2.11c0.965,0,1.748,0.691,1.748,1.544v7.401c0,0.853-0.783,1.544-1.748,1.544h-6.631c-0.965,0-1.748-0.691-1.748-1.544v-8.288C287.374,124.24,288.157,121.609,289.724,119.879z"></path><path fill="#7C8696" d="M657.626,145.424c-1.013,1.118-2.563,1.802-4.651,2.052c-0.822,0.099-1.548-0.492-1.548-1.225v-1.42c0-0.521,0.365-1.008,0.929-1.159c0.667-0.179,1.158-0.473,1.474-0.882c0.449-0.581,0.673-1.452,0.673-2.613v-0.522h-1.682c-0.77,0-1.393-0.551-1.393-1.231v-5.9c0-0.68,0.624-1.231,1.393-1.231h5.286c0.77,0,1.393,0.551,1.393,1.231v6.608C659.5,141.947,658.875,144.045,657.626,145.424z M645.4,149.018c-1.271,1.402-3.215,2.26-5.834,2.574c-1.032,0.124-1.942-0.617-1.942-1.537v-1.782c0-0.654,0.457-1.264,1.166-1.454c0.836-0.224,1.452-0.593,1.848-1.106c0.563-0.729,0.844-1.821,0.844-3.278v-0.655h-2.11c-0.965,0-1.748-0.691-1.748-1.544v-7.401c0-0.853,0.783-1.544,1.748-1.544h6.631c0.965,0,1.748,0.691,1.748,1.544v8.288C647.751,144.657,646.967,147.289,645.4,149.018z"></path><text transform="matrix(1 0 0 1 467.816 138.6864)" font-family="'InterFace-Regular'" font-size="14px" text-anchor="middle">We suggest administering SGLT-2 inhibitors</text></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="164.011,117.552 66.011,117.552 56.011,102.552 66.011,87.552 164.011,87.552 154.011,102.552"></polygon><text transform="matrix(1 0 0 1 84.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Strong</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="160.139" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M160.648,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L160.648,91.629z M160.896,87.026c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C161.774,86.635,161.382,87.026,160.896,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M251.153,185.394h-229.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h108.9l6-6l6,6h109.001c3.2,0,5.5,2.6,5.5,5.7v45.754C256.653,183.194,254.353,185.394,251.153,185.394z"></path><text transform="matrix(1 0 0 1 24.9805 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">All or nearly all informed people would likely</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">want the intervention to the left. Benefits</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">would outweigh harms for almost everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="274.011,117.552 176.011,117.552 166.011,102.552 176.011,87.552 274.011,87.552 264.011,102.552"></polygon><text transform="matrix(1 0 0 1 198.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Weak</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="271.472" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M271.981,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.041,0.436c-0.465,0.243-0.898,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.548-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.578,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L271.981,91.629z M272.229,87.026c-0.476,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.476,0,0.857,0.403,0.857,0.891C273.107,86.635,272.715,87.026,272.229,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M348.293,185.394h-244.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h115.9l6-6l6,6h117.001c3.2,0,5.5,2.6,5.5,5.7v45.754C353.793,183.194,351.493,185.394,348.293,185.394z"></path><text transform="matrix(1 0 0 1 107.1205 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">Most people would likely want the intervention</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">to the left. Benefits would outweigh harms for</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the majority, but not for everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="1" fill="#FFFFFF" points="390.511,117.552 488.511,117.552 498.511,102.552 488.511,87.552 390.511,87.552 400.511,102.552"></polygon><text transform="matrix(1 0 0 1 425.6487 107.8645)" fill="#7D5CC6" font-family="'InterFace-Bold'" font-size="18px">Weak</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="487.595" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M488.104,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L488.104,91.629z M488.352,87.026c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C489.23,86.635,488.838,87.026,488.352,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M573.214,185.394h-244.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h115.9l6-6l6,6h117.001c3.2,0,5.5,2.6,5.5,5.7v45.754C578.714,183.194,576.413,185.394,573.214,185.394z"></path><text transform="matrix(1 0 0 1 332.041 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">Most people would likely want the intervention</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">to the right. Benefits would outweigh harms</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">for the majority, but not for everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="500.511,117.552 598.511,117.552 608.511,102.552 598.511,87.552 500.511,87.552 510.511,102.552"></polygon><text transform="matrix(1 0 0 1 530.6486 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Strong</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="597.928" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M598.437,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.041,0.436c-0.465,0.243-0.898,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.548-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.578,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L598.437,91.629z M598.685,87.026c-0.476,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.476,0,0.857,0.403,0.857,0.891C599.563,86.635,599.171,87.026,598.685,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M649.787,185.394h-231.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h107.9l6-6l6,6h112.001c3.2,0,5.5,2.6,5.5,5.7v45.754C655.287,183.194,652.987,185.394,649.787,185.394z"></path><text transform="matrix(1 0 0 1 421.6153 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">All or nearly all informed people would likely</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">want the intervention to the right. Benefits</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">would outweigh harms for almost everyone</tspan></text></g></g></svg></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 315.4078 21.7755)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Rationale</text><circle fill="#FFFFFF" cx="298.537" cy="16.747" r="10.974"></circle><path fill="#2A6EBB" d="M297.269,19.248v-0.967c0-0.307,0.05-0.605,0.149-0.896s0.226-0.563,0.38-0.816c0.153-0.253,0.318-0.487,0.494-0.702c0.176-0.214,0.341-0.398,0.495-0.552c0.215-0.229,0.433-0.444,0.656-0.644c0.222-0.199,0.421-0.406,0.598-0.621s0.322-0.438,0.437-0.667c0.115-0.23,0.173-0.491,0.173-0.782c0-0.536-0.161-0.95-0.483-1.242c-0.322-0.291-0.782-0.437-1.38-0.437c-0.445,0-0.889,0.126-1.334,0.379s-0.913,0.748-1.403,1.483l-2.208-1.472c0.537-0.843,1.223-1.533,2.059-2.07c0.835-0.536,1.859-0.805,3.07-0.805c1.533,0,2.703,0.384,3.507,1.15c0.805,0.767,1.208,1.802,1.208,3.104c0,0.384-0.057,0.736-0.172,1.059c-0.115,0.321-0.265,0.629-0.449,0.92c-0.184,0.291-0.391,0.563-0.621,0.816s-0.46,0.494-0.69,0.725c-0.399,0.429-0.759,0.839-1.081,1.23c-0.322,0.391-0.483,0.809-0.483,1.253v0.553H297.269z M297.959,24.192c-0.215-0.092-0.406-0.226-0.575-0.402c-0.169-0.176-0.299-0.376-0.391-0.598c-0.092-0.223-0.138-0.456-0.138-0.702c0-0.245,0.046-0.479,0.138-0.701c0.092-0.222,0.222-0.418,0.391-0.587c0.168-0.168,0.364-0.306,0.586-0.413c0.222-0.107,0.472-0.161,0.748-0.161c0.552,0,1.004,0.188,1.357,0.563c0.353,0.376,0.529,0.809,0.529,1.299c0,0.491-0.176,0.924-0.529,1.3c-0.353,0.376-0.805,0.563-1.357,0.563C298.442,24.354,298.189,24.3,297.959,24.192z"></path></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 14.144144144144144%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 94.2" enable-background="0 0 666 94.2" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 109.7213 21.7755)" font-family="'InterFace-Regular'" font-size="14px">Moderate certainty of important reductions in risks of all-cause</text><text transform="matrix(1 0 0 1 109.7213 38.575500000000005)" font-family="'InterFace-Regular'" font-size="14px">mortality and non-fatal stroke, balanced against moderate certainty of</text><text transform="matrix(1 0 0 1 109.7213 55.3755)" font-family="'InterFace-Regular'" font-size="14px">no important increase in the risk of harms led to a weak</text><text transform="matrix(1 0 0 1 109.7213 72.1755)" font-family="'InterFace-Regular'" font-size="14px">recommendation in favour</text></svg></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Potential benefits</text></svg></div></h2><div class="pane-content" style="padding: 0px 0px 10px 0px; max-width: 666px; margin: 0px auto 0px auto;"><div style="clear: both;"></div><div class="scaling-svg-container" style="padding-bottom: 11.562%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 60" enable-background="0 0 666 60" xml:space="preserve" style="width: 100%;"><polygon fill="#00B2A9" points="256.718,43.109 66.888,43.109 54.888,30.943 66.888,18.776 256.718,18.776 243.718,30.943"></polygon><text transform="matrix(1 0 0 1 157.389 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No SGLT-2 inhibitors</text><polygon fill="#765FA8" points="407.721,18.776 597.551,18.776 609.551,30.943 597.551,43.109 407.721,43.109 419.721,30.943"></polygon><text transform="matrix(1 0 0 1 511.128 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">SGLT-2 inhibitors</text><g class="thishasatooltip"><polygon fill="#7C8696" points="403.351,43.109 260.522,43.109 248.522,30.943 260.522,18.776 403.351,18.776 415.351,30.943"></polygon><text transform="matrix(1 0 0 1 332.32 34.4258)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No important difference</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="395.241" cy="18.088" r="6"></circle><path fill="#FFFFFF" d="M395.751,20.48c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L395.751,20.48z M395.999,15.877c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C396.877,15.486,396.484,15.877,395.999,15.877z"></path><g transform="matrix(1 0 0 1 365 5)" class="thisisthetooltip"><path opacity="0.8" enable-background="new " d="M-349.979,51.675c-5.6,0-10.1-4.5-10.1-10.1V10.211c0-5.6,4.5-10.1,10.1-10.1H11.135c5.6,0,10.1,4.5,10.1,10.1v5.2l10,10l-10,10v6.264c0,5.6-4.5,10.1-10.1,10.1L-349.979,51.675z"></path><text transform="matrix(1 0 0 1 -353.0981 16.7624)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">The panel found that this difference was not important for most patients,</tspan><tspan x="0" y="13" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">because the intervention effects were negligible and/or very imprecise, for</tspan><tspan x="0" y="26" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">example confidence intervals that include both important benefit and harm</tspan></text></g></g></svg></div><div class="scaling-svg-container" style="padding-bottom: 3.003%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 20" enable-background="0 0 666 20" xml:space="preserve" style="width: 100%;"><text transform="matrix(0.9746 0 0 1 14.0746 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Benefits</text><path fill="none" stroke="#7C8696" stroke-miterlimit="10" d="M441.083,17.13c0,0,0-1.791,0-3.98s-2.122-3.98-4.716-3.98H189.049c-2.594,0-4.716,1.791-4.716,3.98s0,3.98,0,3.98"></path><rect x="210.591642578125" y="5" fill="#C1D3E9" width="204.03271484375" height="8"></rect><text transform="matrix(0.9746 0 0 1 312.608 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">Events per 1000 people over 5 years</text><text transform="matrix(0.9746 0 0 1 488.304 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Evidence quality</text></svg></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">All-cause mortality</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">13 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">84</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">71</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="271.0919494628906" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 28 981 patients in 11 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">all-cause mortality</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" stroke="#FFFFFF" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Cardiovascular mortality</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">20</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">17</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 27 429 patients in 7 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably have little</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">or no effect on cardiovascular mortality</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-309.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-309.8,69-310,68.9-309.9,68.7z"></path><path fill="#FFFFFF" d="M-201,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-200.9,69-201.1,68.9-201,68.7z"></path><path fill="#FFFFFF" d="M-190.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-190,69-190.3,68.9-190.2,68.7z"></path><path fill="#FFFFFF" d="M-179.4,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-179.2,69-179.4,68.9-179.4,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Kidney failure</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">1</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">1</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 28 221 patients in 9 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors have little or no</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">effect on kidney failure</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Non-fatal myocardial infarction</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">73</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">55</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 16 049 patients in 4 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably have little</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">or no effect on non-fatal myocardial</tspan><tspan x="0" y="29.492" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">infarction</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Non-fatal stroke</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">13 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">49</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">36</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 16 049 patients in 4 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">non-fatal stroke</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Admission for heart failure</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">27</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">18</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 26 962 patients in 6 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors have little or no</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">effect on hospital admission for heart</tspan><tspan x="0" y="29.492" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">failure</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><a xlink:href="javascript:void(0)" onclick="window.open('https://app.magicapp.org/widget/pico/?gId=EezrQj&picoId=nJBaqe&tab=outcome','PICO','width=800,height=600,left=0,top=0')"><div class="magicLink1" style="margin: 10px 5px 5px 10px; height: 18px; max-width: 206.71409106445313px; float: left;"><svg version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 206.71409106445313 18" enable-background="0 0 206.71409106445313 18" xml:space="preserve" style="width: 100%;"><circle fill="#FFFFFF" cx="9" cy="9" r="9"></circle><circle fill="#FFFFFF" cx="197.71409106445313" cy="9" r="9"></circle><rect fill="#FFFFFF" x="9" height="18" width="188.71409106445313"></rect><path fill="#FFFFFF" 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d="M191.45,26.7c-0.078,0.359-0.209,0.648-0.385,0.866c-0.175,0.22-0.409,0.376-0.699,0.468c-0.289,0.095-0.642,0.139-1.06,0.139h-0.173c-0.058,0-0.114-0.003-0.172-0.008v1.562h-1.281v-6.002c0,0,0.632-0.541,2.323-0.541c0.262,0,0.492,0.036,0.692,0.112c0.198,0.072,0.362,0.195,0.491,0.362c0.127,0.167,0.225,0.39,0.289,0.668s0.098,0.629,0.098,1.047C191.572,25.898,191.53,26.341,191.45,26.7z M190.141,24.509c-0.05-0.086-0.111-0.147-0.19-0.178c-0.076-0.034-0.173-0.048-0.289-0.048c-0.211,0-0.701,0.095-0.701,0.268v2.505c0.07,0.006,0.142,0.012,0.211,0.014c0.07,0.006,0.14,0.006,0.203,0.006c0.178,0,0.326-0.02,0.443-0.064c0.114-0.039,0.206-0.12,0.273-0.239c0.069-0.12,0.114-0.284,0.142-0.493c0.025-0.206,0.039-0.479,0.039-0.813c0-0.242-0.011-0.443-0.03-0.596C190.222,24.715,190.189,24.596,190.141,24.509z"></path></g></svg></div></a><div class="scaling-svg-container" style="padding-bottom: 5.045045045045046%; max-width: 666px; margin: 15px auto 0px auto; clear: both;"><svg version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 33.6" enable-background="0 0 666 33.6" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 15.0713 20.0906)" fill="#000000" font-family="'InterFace-Regular'" font-size="14px">See below for summary of harms</text></svg></div><div style="clear:both;"></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Individual considerations</text></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 22.16216216216216%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 147.6" enable-background="0 0 666 147.6" xml:space="preserve" style="width: 100%;"><rect fill="#FFFFFF" x="16.5" y="16.471" width="633" height="125.6" rx="12" ry="12"></rect><path fill="#2A6EBB" d="M16.5,46.419V28.471c0-6.6,5.4-12,12-12h609c6.6,0,12,5.4,12,12v17.948"></path><text transform="matrix(1 0 0 1 333 36)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Values and preferences</text><text transform="matrix(1 0 0 1 125 70)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">The panel inferred that the majority of individuals would be inclined to receive</text><text transform="matrix(1 0 0 1 125 84.4)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">SGLT-2 inhibitors, though a substantial proportion may be disinclined to do the</text><text transform="matrix(1 0 0 1 125 98.80000000000001)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">same, given the degree of benefits, increased pill burden, medication costs and a</text><text transform="matrix(1 0 0 1 125 113.20000000000002)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">residual risk of harms</text></svg></div></div></div></div></div><div class="whiteBox" style="margin:15px; padding:10px; background-color: #FFF; border-radius: 12px;"><div class="scaling-svg-container" style="padding-bottom: 11.223%; max-width: 695px; margin: 0px auto 0px auto"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 695 78" enable-background="0 0 695 78" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 55.1034 36.7349)" fill="#333333" font-family="'InterFace-Bold'" font-size="21px">Recommendation 3</text><path fill="#7C8696" d="M33.809,20.915c-7.32,0-13.254,3.258-13.254,7.277c0,2.436,2.187,4.586,5.534,5.907l-1.029,7.434l6.421-6.183c0.757,0.074,1.533,0.119,2.328,0.119c7.32,0,13.254-3.258,13.254-7.277S41.129,20.915,33.809,20.915z"></path></svg></div><div class="scaling-svg-container" style="padding-bottom: 24.89208633093525%; max-width: 695px; margin: 0px auto 0px auto"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 695 173" enable-background="0 0 695 173" xml:space="preserve" style="width: 100%;"><path fill="#D8DBDF" d="M34.5,0 h626 a20,20 0 0 1 20,20 v120 a20,20 0 0 1 -20,20 h-626 a20,20 0 0 1 -20,-20 v-120 a20,20 0 0 1 20,-20"></path><path fill="#00B2A9" d="M34.5,0 h313 v90 h-333 v-70 a20,20 0 0 1 20,-20"></path><path fill="#765FA8" d="M347.5,0 h313 a20,20 0 0 1 20,20 v70 h-333 z"></path><text transform="matrix(1 0 0 1 184 28)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="18px" text-anchor="middle">No SGLT-2 inhibitors</text><text transform="matrix(1 0 0 1 511 28)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="18px" text-anchor="middle">SGLT-2 inhibitors</text><line fill="none" stroke="#FFFFFF" stroke-width="3" stroke-miterlimit="10" x1="347.5" y1="0" x2="347.5" y2="90"></line><circle fill="#FFFFFF" cx="347.776" cy="46.175" r="15.575"></circle><text transform="matrix(1 0 0 1 339.7538 50.7762)" font-family="'InterFace-Regular'" font-size="18px">or</text><g transform="translate(0,-10.598800000000011)"><path fill="#FFFFFF" d="M252.351,158.478H42.009c-8.182,0-14.876-6.694-14.876-14.876v-23.514c0-4.28,3.502-7.781,7.781-7.781h217.438c4.28,0,7.781,3.502,7.781,7.781v30.609C260.132,154.976,256.631,158.478,252.351,158.478z"></path><g transform="translate(0,0)"><path fill="#7C8696" d="M36.955,126.089c0-1.686,1.395-3.052,3.116-3.052c1.721,0,3.117,1.366,3.117,3.052c0,1.685-1.396,3.052-3.117,3.052C38.351,129.141,36.955,127.774,36.955,126.089z"></path><path fill="#7C8696" d="M40.236,130.024h-0.328c-2.174,0-3.936,0.456-3.936,3.855v2.209c0,1.474,0.531,2.295,1.368,2.737l0.602,6.887h4.182l0.6-6.855c0.883-0.439,1.449-1.27,1.449-2.769v-2.209C44.173,130.425,42.41,130.024,40.236,130.024z"></path><path fill="#7C8696" d="M46.749,124.235c0-1.931,1.598-3.496,3.57-3.496c1.971,0,3.57,1.565,3.57,3.496c0,1.93-1.599,3.496-3.57,3.496C48.347,127.731,46.749,126.166,46.749,124.235z"></path><path fill="#7C8696" d="M50.507,128.742h-0.376c-2.49,0-4.509,0.522-4.509,4.415v2.53c0,1.689,0.609,2.629,1.567,3.136l0.69,7.888h4.791l0.687-7.852c1.012-0.503,1.659-1.455,1.659-3.171v-2.53C55.016,129.202,52.997,128.742,50.507,128.742z"></path><path fill="#7C8696" d="M57.363,126.826c0-1.537,1.272-2.782,2.84-2.782c1.569,0,2.841,1.245,2.841,2.782c0,1.536-1.272,2.782-2.841,2.782C58.634,129.608,57.363,128.362,57.363,126.826z"></path><path fill="#7C8696" d="M60.353,130.412h-0.299c-1.982,0-3.588,0.415-3.588,3.514v2.013c0,1.344,0.484,2.092,1.247,2.495l0.549,6.277h3.812l0.547-6.248c0.805-0.4,1.32-1.157,1.32-2.524v-2.013C63.941,130.778,62.334,130.412,60.353,130.412z"></path></g><text transform="matrix(1 0 0 1 74.466 138.498)" font-family="'InterFace-Regular'" font-size="14px">High risk</text></g><g transform="translate(0,-10.598800000000011)"><path fill="#FFFFFF" d="M276.914,158.478h375.71c8.182,0,14.876-6.694,14.876-14.876v-23.514c0-4.28-3.502-7.781-7.781-7.781H276.914c-4.28,0-7.781,3.502-7.781,7.781v30.609C269.132,154.976,272.634,158.478,276.914,158.478z"></path><path fill="#7C8696" d="M277.498,123.473c1.013-1.118,2.563-1.802,4.651-2.052c0.822-0.099,1.548,0.492,1.548,1.225v1.42c0,0.521-0.365,1.008-0.929,1.159c-0.667,0.179-1.158,0.473-1.474,0.881c-0.449,0.581-0.673,1.452-0.673,2.613v0.522h1.682c0.77,0,1.393,0.551,1.393,1.231v5.9c0,0.68-0.624,1.231-1.393,1.231h-5.286c-0.77,0-1.393-0.551-1.393-1.231v-6.608C275.624,126.95,276.249,124.852,277.498,123.473z M289.724,119.879c1.271-1.402,3.215-2.26,5.834-2.574c1.032-0.124,1.942,0.617,1.942,1.537v1.782c0,0.654-0.457,1.264-1.165,1.454c-0.836,0.224-1.452,0.593-1.848,1.106c-0.563,0.729-0.844,1.821-0.844,3.278v0.655h2.11c0.965,0,1.748,0.691,1.748,1.544v7.401c0,0.853-0.783,1.544-1.748,1.544h-6.631c-0.965,0-1.748-0.691-1.748-1.544v-8.288C287.374,124.24,288.157,121.609,289.724,119.879z"></path><path fill="#7C8696" d="M657.626,145.424c-1.013,1.118-2.563,1.802-4.651,2.052c-0.822,0.099-1.548-0.492-1.548-1.225v-1.42c0-0.521,0.365-1.008,0.929-1.159c0.667-0.179,1.158-0.473,1.474-0.882c0.449-0.581,0.673-1.452,0.673-2.613v-0.522h-1.682c-0.77,0-1.393-0.551-1.393-1.231v-5.9c0-0.68,0.624-1.231,1.393-1.231h5.286c0.77,0,1.393,0.551,1.393,1.231v6.608C659.5,141.947,658.875,144.045,657.626,145.424z M645.4,149.018c-1.271,1.402-3.215,2.26-5.834,2.574c-1.032,0.124-1.942-0.617-1.942-1.537v-1.782c0-0.654,0.457-1.264,1.166-1.454c0.836-0.224,1.452-0.593,1.848-1.106c0.563-0.729,0.844-1.821,0.844-3.278v-0.655h-2.11c-0.965,0-1.748-0.691-1.748-1.544v-7.401c0-0.853,0.783-1.544,1.748-1.544h6.631c0.965,0,1.748,0.691,1.748,1.544v8.288C647.751,144.657,646.967,147.289,645.4,149.018z"></path><text transform="matrix(1 0 0 1 467.816 138.6864)" font-family="'InterFace-Regular'" font-size="14px" text-anchor="middle">We recommend administering SGLT-2 inhibitors</text></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="164.011,117.552 66.011,117.552 56.011,102.552 66.011,87.552 164.011,87.552 154.011,102.552"></polygon><text transform="matrix(1 0 0 1 81.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Strong</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="160.139" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M160.648,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L160.648,91.629z M160.896,87.026c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C161.774,86.635,161.382,87.026,160.896,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M251.153,185.394h-229.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h108.9l6-6l6,6h109.001c3.2,0,5.5,2.6,5.5,5.7v45.754C256.653,183.194,254.353,185.394,251.153,185.394z"></path><text transform="matrix(1 0 0 1 24.9805 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">All or nearly all informed people would likely</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">want the intervention to the left. Benefits</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">would outweigh harms for almost everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="274.011,117.552 176.011,117.552 166.011,102.552 176.011,87.552 274.011,87.552 264.011,102.552"></polygon><text transform="matrix(1 0 0 1 198.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Weak</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="271.472" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M271.981,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.041,0.436c-0.465,0.243-0.898,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.548-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.578,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L271.981,91.629z M272.229,87.026c-0.476,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.476,0,0.857,0.403,0.857,0.891C273.107,86.635,272.715,87.026,272.229,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M348.293,185.394h-244.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h115.9l6-6l6,6h117.001c3.2,0,5.5,2.6,5.5,5.7v45.754C353.793,183.194,351.493,185.394,348.293,185.394z"></path><text transform="matrix(1 0 0 1 107.1205 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">Most people would likely want the intervention</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">to the left. Benefits would outweigh harms for</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the majority, but not for everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="390.511,117.552 488.511,117.552 498.511,102.552 488.511,87.552 390.511,87.552 400.511,102.552"></polygon><text transform="matrix(1 0 0 1 425.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Weak</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="487.595" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M488.104,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L488.104,91.629z M488.352,87.026c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C489.23,86.635,488.838,87.026,488.352,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M573.214,185.394h-244.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h115.9l6-6l6,6h117.001c3.2,0,5.5,2.6,5.5,5.7v45.754C578.714,183.194,576.413,185.394,573.214,185.394z"></path><text transform="matrix(1 0 0 1 332.041 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">Most people would likely want the intervention</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">to the right. Benefits would outweigh harms</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">for the majority, but not for everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="1" fill="#FFFFFF" points="500.511,117.552 598.511,117.552 608.511,102.552 598.511,87.552 500.511,87.552 510.511,102.552"></polygon><text transform="matrix(1 0 0 1 527.6486 107.8645)" fill="#7D5CC6" font-family="'InterFace-Bold'" font-size="18px">Strong</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="597.928" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M598.437,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.041,0.436c-0.465,0.243-0.898,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.548-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.578,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L598.437,91.629z M598.685,87.026c-0.476,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.476,0,0.857,0.403,0.857,0.891C599.563,86.635,599.171,87.026,598.685,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M649.787,185.394h-231.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h107.9l6-6l6,6h112.001c3.2,0,5.5,2.6,5.5,5.7v45.754C655.287,183.194,652.987,185.394,649.787,185.394z"></path><text transform="matrix(1 0 0 1 421.6153 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">All or nearly all informed people would likely</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">want the intervention to the right. Benefits</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">would outweigh harms for almost everyone</tspan></text></g></g></svg></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 315.4078 21.7755)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Rationale</text><circle fill="#FFFFFF" cx="298.537" cy="16.747" r="10.974"></circle><path fill="#2A6EBB" d="M297.269,19.248v-0.967c0-0.307,0.05-0.605,0.149-0.896s0.226-0.563,0.38-0.816c0.153-0.253,0.318-0.487,0.494-0.702c0.176-0.214,0.341-0.398,0.495-0.552c0.215-0.229,0.433-0.444,0.656-0.644c0.222-0.199,0.421-0.406,0.598-0.621s0.322-0.438,0.437-0.667c0.115-0.23,0.173-0.491,0.173-0.782c0-0.536-0.161-0.95-0.483-1.242c-0.322-0.291-0.782-0.437-1.38-0.437c-0.445,0-0.889,0.126-1.334,0.379s-0.913,0.748-1.403,1.483l-2.208-1.472c0.537-0.843,1.223-1.533,2.059-2.07c0.835-0.536,1.859-0.805,3.07-0.805c1.533,0,2.703,0.384,3.507,1.15c0.805,0.767,1.208,1.802,1.208,3.104c0,0.384-0.057,0.736-0.172,1.059c-0.115,0.321-0.265,0.629-0.449,0.92c-0.184,0.291-0.391,0.563-0.621,0.816s-0.46,0.494-0.69,0.725c-0.399,0.429-0.759,0.839-1.081,1.23c-0.322,0.391-0.483,0.809-0.483,1.253v0.553H297.269z M297.959,24.192c-0.215-0.092-0.406-0.226-0.575-0.402c-0.169-0.176-0.299-0.376-0.391-0.598c-0.092-0.223-0.138-0.456-0.138-0.702c0-0.245,0.046-0.479,0.138-0.701c0.092-0.222,0.222-0.418,0.391-0.587c0.168-0.168,0.364-0.306,0.586-0.413c0.222-0.107,0.472-0.161,0.748-0.161c0.552,0,1.004,0.188,1.357,0.563c0.353,0.376,0.529,0.809,0.529,1.299c0,0.491-0.176,0.924-0.529,1.3c-0.353,0.376-0.805,0.563-1.357,0.563C298.442,24.354,298.189,24.3,297.959,24.192z"></path></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 14.144144144144144%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 94.2" enable-background="0 0 666 94.2" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 109.7213 21.7755)" font-family="'InterFace-Regular'" font-size="14px">Moderate certainty of important reductions in risks of mortality and</text><text transform="matrix(1 0 0 1 109.7213 38.575500000000005)" font-family="'InterFace-Regular'" font-size="14px">most cardiovascular and kidney outcomes, combined with moderate</text><text transform="matrix(1 0 0 1 109.7213 55.3755)" font-family="'InterFace-Regular'" font-size="14px">certainty of no important increase in the risk of harms led to a</text><text transform="matrix(1 0 0 1 109.7213 72.1755)" font-family="'InterFace-Regular'" font-size="14px">strong recommendation in favour of treatment</text></svg></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Potential benefits</text></svg></div></h2><div class="pane-content" style="padding: 0px 0px 10px 0px; max-width: 666px; margin: 0px auto 0px auto;"><div style="clear: both;"></div><div class="scaling-svg-container" style="padding-bottom: 11.562%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 60" enable-background="0 0 666 60" xml:space="preserve" style="width: 100%;"><polygon fill="#00B2A9" points="256.718,43.109 66.888,43.109 54.888,30.943 66.888,18.776 256.718,18.776 243.718,30.943"></polygon><text transform="matrix(1 0 0 1 157.389 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No SGLT-2 inhibitors</text><polygon fill="#765FA8" points="407.721,18.776 597.551,18.776 609.551,30.943 597.551,43.109 407.721,43.109 419.721,30.943"></polygon><text transform="matrix(1 0 0 1 511.128 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">SGLT-2 inhibitors</text><g class="thishasatooltip"><polygon fill="#7C8696" points="403.351,43.109 260.522,43.109 248.522,30.943 260.522,18.776 403.351,18.776 415.351,30.943"></polygon><text transform="matrix(1 0 0 1 332.32 34.4258)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No important difference</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="395.241" cy="18.088" r="6"></circle><path fill="#FFFFFF" d="M395.751,20.48c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L395.751,20.48z M395.999,15.877c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C396.877,15.486,396.484,15.877,395.999,15.877z"></path><g transform="matrix(1 0 0 1 365 5)" class="thisisthetooltip"><path opacity="0.8" enable-background="new " d="M-349.979,51.675c-5.6,0-10.1-4.5-10.1-10.1V10.211c0-5.6,4.5-10.1,10.1-10.1H11.135c5.6,0,10.1,4.5,10.1,10.1v5.2l10,10l-10,10v6.264c0,5.6-4.5,10.1-10.1,10.1L-349.979,51.675z"></path><text transform="matrix(1 0 0 1 -353.0981 16.7624)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">The panel found that this difference was not important for most patients,</tspan><tspan x="0" y="13" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">because the intervention effects were negligible and/or very imprecise, for</tspan><tspan x="0" y="26" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">example confidence intervals that include both important benefit and harm</tspan></text></g></g></svg></div><div class="scaling-svg-container" style="padding-bottom: 3.003%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 20" enable-background="0 0 666 20" xml:space="preserve" style="width: 100%;"><text transform="matrix(0.9746 0 0 1 14.0746 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Benefits</text><path fill="none" stroke="#7C8696" stroke-miterlimit="10" d="M441.083,17.13c0,0,0-1.791,0-3.98s-2.122-3.98-4.716-3.98H189.049c-2.594,0-4.716,1.791-4.716,3.98s0,3.98,0,3.98"></path><rect x="210.591642578125" y="5" fill="#C1D3E9" width="204.03271484375" height="8"></rect><text transform="matrix(0.9746 0 0 1 312.608 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">Events per 1000 people over 5 years</text><text transform="matrix(0.9746 0 0 1 488.304 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Evidence quality</text></svg></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">All-cause mortality</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">24 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">159</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">135</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="271.0919494628906" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 28 981 patients in 11 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">all-cause mortality</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" stroke="#FFFFFF" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Cardiovascular mortality</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">6 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">37</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">31</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 27 429 patients in 7 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">cardiovascular mortality</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Kidney failure</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">9</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">6</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 28 221 patients in 9 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors have little or no</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">effect on kidney failure</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-309.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-309.8,69-310,68.9-309.9,68.7z"></path><path fill="#FFFFFF" d="M-201,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-200.9,69-201.1,68.9-201,68.7z"></path><path fill="#FFFFFF" d="M-190.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-190,69-190.3,68.9-190.2,68.7z"></path><path fill="#FFFFFF" d="M-179.4,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-179.2,69-179.4,68.9-179.4,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Non-fatal myocardial infarction</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">21 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">85</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">64</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 16 049 patients in 4 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">non-fatal myocardial infarction</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" 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d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Non-fatal stroke</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">21 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">78</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">57</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 16 049 patients in 4 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">non-fatal stroke</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Admission for heart failure</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">40</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">27</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 26 962 patients in 6 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors have little or no</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">effect on hospital admission for heart</tspan><tspan x="0" y="29.492" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">failure</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><a xlink:href="javascript:void(0)" onclick="window.open('https://app.magicapp.org/widget/pico/?gId=EezrQj&picoId=L48om5&tab=outcome','PICO','width=800,height=600,left=0,top=0')"><div class="magicLink1" style="margin: 10px 5px 5px 10px; height: 18px; max-width: 206.71409106445313px; float: left;"><svg version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 206.71409106445313 18" enable-background="0 0 206.71409106445313 18" xml:space="preserve" style="width: 100%;"><circle fill="#FFFFFF" cx="9" cy="9" r="9"></circle><circle fill="#FFFFFF" cx="197.71409106445313" cy="9" r="9"></circle><rect fill="#FFFFFF" x="9" height="18" width="188.71409106445313"></rect><path fill="#FFFFFF" 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xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 33.6" enable-background="0 0 666 33.6" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 15.0713 20.0906)" fill="#000000" font-family="'InterFace-Regular'" font-size="14px">See below for summary of harms</text></svg></div><div style="clear:both;"></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Individual considerations</text></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 20%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 133.2" enable-background="0 0 666 133.2" xml:space="preserve" style="width: 100%;"><rect fill="#FFFFFF" x="16.5" y="16.471" width="633" height="111.19999999999999" rx="12" ry="12"></rect><path fill="#2A6EBB" d="M16.5,46.419V28.471c0-6.6,5.4-12,12-12h609c6.6,0,12,5.4,12,12v17.948"></path><text transform="matrix(1 0 0 1 333 36)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Values and preferences</text><text transform="matrix(1 0 0 1 125 70)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">The panel inferred that all or almost all individuals would be inclined to receive</text><text transform="matrix(1 0 0 1 125 84.4)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">SGLT-2 inhibitors, given benefits substantially outweigh possible harms. No</text><text transform="matrix(1 0 0 1 125 98.80000000000001)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">significant variability in patient preference was anticipated</text></svg></div></div></div></div></div><div class="whiteBox" style="margin:15px; padding:10px; background-color: #FFF; border-radius: 12px;"><div class="scaling-svg-container" style="padding-bottom: 11.223%; max-width: 695px; margin: 0px auto 0px auto"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 695 78" enable-background="0 0 695 78" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 55.1034 36.7349)" fill="#333333" font-family="'InterFace-Bold'" font-size="21px">Recommendation 4</text><path fill="#7C8696" d="M33.809,20.915c-7.32,0-13.254,3.258-13.254,7.277c0,2.436,2.187,4.586,5.534,5.907l-1.029,7.434l6.421-6.183c0.757,0.074,1.533,0.119,2.328,0.119c7.32,0,13.254-3.258,13.254-7.277S41.129,20.915,33.809,20.915z"></path></svg></div><div class="scaling-svg-container" style="padding-bottom: 24.89208633093525%; max-width: 695px; margin: 0px auto 0px auto"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 695 173" enable-background="0 0 695 173" xml:space="preserve" style="width: 100%;"><path fill="#D8DBDF" d="M34.5,0 h626 a20,20 0 0 1 20,20 v120 a20,20 0 0 1 -20,20 h-626 a20,20 0 0 1 -20,-20 v-120 a20,20 0 0 1 20,-20"></path><path fill="#00B2A9" d="M34.5,0 h313 v90 h-333 v-70 a20,20 0 0 1 20,-20"></path><path fill="#765FA8" d="M347.5,0 h313 a20,20 0 0 1 20,20 v70 h-333 z"></path><text transform="matrix(1 0 0 1 184 28)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="18px" text-anchor="middle">No SGLT-2 inhibitors</text><text transform="matrix(1 0 0 1 511 28)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="18px" text-anchor="middle">SGLT-2 inhibitors</text><line fill="none" stroke="#FFFFFF" stroke-width="3" stroke-miterlimit="10" x1="347.5" y1="0" x2="347.5" y2="90"></line><circle fill="#FFFFFF" cx="347.776" cy="46.175" r="15.575"></circle><text transform="matrix(1 0 0 1 339.7538 50.7762)" font-family="'InterFace-Regular'" font-size="18px">or</text><g transform="translate(0,-10.598800000000011)"><path fill="#FFFFFF" d="M252.351,158.478H42.009c-8.182,0-14.876-6.694-14.876-14.876v-23.514c0-4.28,3.502-7.781,7.781-7.781h217.438c4.28,0,7.781,3.502,7.781,7.781v30.609C260.132,154.976,256.631,158.478,252.351,158.478z"></path><g transform="translate(0,0)"><path fill="#7C8696" d="M36.955,126.089c0-1.686,1.395-3.052,3.116-3.052c1.721,0,3.117,1.366,3.117,3.052c0,1.685-1.396,3.052-3.117,3.052C38.351,129.141,36.955,127.774,36.955,126.089z"></path><path fill="#7C8696" d="M40.236,130.024h-0.328c-2.174,0-3.936,0.456-3.936,3.855v2.209c0,1.474,0.531,2.295,1.368,2.737l0.602,6.887h4.182l0.6-6.855c0.883-0.439,1.449-1.27,1.449-2.769v-2.209C44.173,130.425,42.41,130.024,40.236,130.024z"></path><path fill="#7C8696" d="M46.749,124.235c0-1.931,1.598-3.496,3.57-3.496c1.971,0,3.57,1.565,3.57,3.496c0,1.93-1.599,3.496-3.57,3.496C48.347,127.731,46.749,126.166,46.749,124.235z"></path><path fill="#7C8696" d="M50.507,128.742h-0.376c-2.49,0-4.509,0.522-4.509,4.415v2.53c0,1.689,0.609,2.629,1.567,3.136l0.69,7.888h4.791l0.687-7.852c1.012-0.503,1.659-1.455,1.659-3.171v-2.53C55.016,129.202,52.997,128.742,50.507,128.742z"></path><path fill="#7C8696" d="M57.363,126.826c0-1.537,1.272-2.782,2.84-2.782c1.569,0,2.841,1.245,2.841,2.782c0,1.536-1.272,2.782-2.841,2.782C58.634,129.608,57.363,128.362,57.363,126.826z"></path><path fill="#7C8696" d="M60.353,130.412h-0.299c-1.982,0-3.588,0.415-3.588,3.514v2.013c0,1.344,0.484,2.092,1.247,2.495l0.549,6.277h3.812l0.547-6.248c0.805-0.4,1.32-1.157,1.32-2.524v-2.013C63.941,130.778,62.334,130.412,60.353,130.412z"></path></g><text transform="matrix(1 0 0 1 74.466 138.498)" font-family="'InterFace-Regular'" font-size="14px">Very high risk</text></g><g transform="translate(0,-10.598800000000011)"><path fill="#FFFFFF" d="M276.914,158.478h375.71c8.182,0,14.876-6.694,14.876-14.876v-23.514c0-4.28-3.502-7.781-7.781-7.781H276.914c-4.28,0-7.781,3.502-7.781,7.781v30.609C269.132,154.976,272.634,158.478,276.914,158.478z"></path><path fill="#7C8696" d="M277.498,123.473c1.013-1.118,2.563-1.802,4.651-2.052c0.822-0.099,1.548,0.492,1.548,1.225v1.42c0,0.521-0.365,1.008-0.929,1.159c-0.667,0.179-1.158,0.473-1.474,0.881c-0.449,0.581-0.673,1.452-0.673,2.613v0.522h1.682c0.77,0,1.393,0.551,1.393,1.231v5.9c0,0.68-0.624,1.231-1.393,1.231h-5.286c-0.77,0-1.393-0.551-1.393-1.231v-6.608C275.624,126.95,276.249,124.852,277.498,123.473z M289.724,119.879c1.271-1.402,3.215-2.26,5.834-2.574c1.032-0.124,1.942,0.617,1.942,1.537v1.782c0,0.654-0.457,1.264-1.165,1.454c-0.836,0.224-1.452,0.593-1.848,1.106c-0.563,0.729-0.844,1.821-0.844,3.278v0.655h2.11c0.965,0,1.748,0.691,1.748,1.544v7.401c0,0.853-0.783,1.544-1.748,1.544h-6.631c-0.965,0-1.748-0.691-1.748-1.544v-8.288C287.374,124.24,288.157,121.609,289.724,119.879z"></path><path fill="#7C8696" d="M657.626,145.424c-1.013,1.118-2.563,1.802-4.651,2.052c-0.822,0.099-1.548-0.492-1.548-1.225v-1.42c0-0.521,0.365-1.008,0.929-1.159c0.667-0.179,1.158-0.473,1.474-0.882c0.449-0.581,0.673-1.452,0.673-2.613v-0.522h-1.682c-0.77,0-1.393-0.551-1.393-1.231v-5.9c0-0.68,0.624-1.231,1.393-1.231h5.286c0.77,0,1.393,0.551,1.393,1.231v6.608C659.5,141.947,658.875,144.045,657.626,145.424z M645.4,149.018c-1.271,1.402-3.215,2.26-5.834,2.574c-1.032,0.124-1.942-0.617-1.942-1.537v-1.782c0-0.654,0.457-1.264,1.166-1.454c0.836-0.224,1.452-0.593,1.848-1.106c0.563-0.729,0.844-1.821,0.844-3.278v-0.655h-2.11c-0.965,0-1.748-0.691-1.748-1.544v-7.401c0-0.853,0.783-1.544,1.748-1.544h6.631c0.965,0,1.748,0.691,1.748,1.544v8.288C647.751,144.657,646.967,147.289,645.4,149.018z"></path><text transform="matrix(1 0 0 1 467.816 138.6864)" font-family="'InterFace-Regular'" font-size="14px" text-anchor="middle">We recommend administering SGLT-2 inhibitors</text></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="164.011,117.552 66.011,117.552 56.011,102.552 66.011,87.552 164.011,87.552 154.011,102.552"></polygon><text transform="matrix(1 0 0 1 81.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Strong</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="160.139" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M160.648,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L160.648,91.629z M160.896,87.026c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C161.774,86.635,161.382,87.026,160.896,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M251.153,185.394h-229.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h108.9l6-6l6,6h109.001c3.2,0,5.5,2.6,5.5,5.7v45.754C256.653,183.194,254.353,185.394,251.153,185.394z"></path><text transform="matrix(1 0 0 1 24.9805 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">All or nearly all informed people would likely</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">want the intervention to the left. Benefits</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">would outweigh harms for almost everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="274.011,117.552 176.011,117.552 166.011,102.552 176.011,87.552 274.011,87.552 264.011,102.552"></polygon><text transform="matrix(1 0 0 1 198.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Weak</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="271.472" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M271.981,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.041,0.436c-0.465,0.243-0.898,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.548-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.578,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L271.981,91.629z M272.229,87.026c-0.476,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.476,0,0.857,0.403,0.857,0.891C273.107,86.635,272.715,87.026,272.229,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M348.293,185.394h-244.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h115.9l6-6l6,6h117.001c3.2,0,5.5,2.6,5.5,5.7v45.754C353.793,183.194,351.493,185.394,348.293,185.394z"></path><text transform="matrix(1 0 0 1 107.1205 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">Most people would likely want the intervention</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">to the left. Benefits would outweigh harms for</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the majority, but not for everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="0.2" fill="#FFFFFF" points="390.511,117.552 488.511,117.552 498.511,102.552 488.511,87.552 390.511,87.552 400.511,102.552"></polygon><text transform="matrix(1 0 0 1 425.6487 107.8645)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="18px">Weak</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="487.595" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M488.104,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L488.104,91.629z M488.352,87.026c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C489.23,86.635,488.838,87.026,488.352,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M573.214,185.394h-244.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h115.9l6-6l6,6h117.001c3.2,0,5.5,2.6,5.5,5.7v45.754C578.714,183.194,576.413,185.394,573.214,185.394z"></path><text transform="matrix(1 0 0 1 332.041 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">Most people would likely want the intervention</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">to the right. Benefits would outweigh harms</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">for the majority, but not for everyone</tspan></text></g></g><g class="thishasatooltip" transform="translate(14.4892, -42.398799999999994)"><polygon opacity="1" fill="#FFFFFF" points="500.511,117.552 598.511,117.552 608.511,102.552 598.511,87.552 500.511,87.552 510.511,102.552"></polygon><text transform="matrix(1 0 0 1 527.6486 107.8645)" fill="#7D5CC6" font-family="'InterFace-Bold'" font-size="18px">Strong</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="597.928" cy="89.237" r="6"></circle><path fill="#FFFFFF" d="M598.437,91.629c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.041,0.436c-0.465,0.243-0.898,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.548-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.578,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L598.437,91.629z M598.685,87.026c-0.476,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.476,0,0.857,0.403,0.857,0.891C599.563,86.635,599.171,87.026,598.685,87.026z"></path><g class="thisisthetooltip" transform="matrix(1 0 0 1 0 0)"><path opacity="0.8" enable-background="new " d="M649.787,185.394h-231.9c-3.2,0-6.1-2.2-6.1-5.4V134.14c0-3.1,2.9-5.7,6.1-5.7h107.9l6-6l6,6h112.001c3.2,0,5.5,2.6,5.5,5.7v45.754C655.287,183.194,652.987,185.394,649.787,185.394z"></path><text transform="matrix(1 0 0 1 421.6153 145.54)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">All or nearly all informed people would likely</tspan><tspan x="0" y="13.8" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">want the intervention to the right. Benefits</tspan><tspan x="0" y="27.6" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">would outweigh harms for almost everyone</tspan></text></g></g></svg></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 315.4078 21.7755)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Rationale</text><circle fill="#FFFFFF" cx="298.537" cy="16.747" r="10.974"></circle><path fill="#2A6EBB" d="M297.269,19.248v-0.967c0-0.307,0.05-0.605,0.149-0.896s0.226-0.563,0.38-0.816c0.153-0.253,0.318-0.487,0.494-0.702c0.176-0.214,0.341-0.398,0.495-0.552c0.215-0.229,0.433-0.444,0.656-0.644c0.222-0.199,0.421-0.406,0.598-0.621s0.322-0.438,0.437-0.667c0.115-0.23,0.173-0.491,0.173-0.782c0-0.536-0.161-0.95-0.483-1.242c-0.322-0.291-0.782-0.437-1.38-0.437c-0.445,0-0.889,0.126-1.334,0.379s-0.913,0.748-1.403,1.483l-2.208-1.472c0.537-0.843,1.223-1.533,2.059-2.07c0.835-0.536,1.859-0.805,3.07-0.805c1.533,0,2.703,0.384,3.507,1.15c0.805,0.767,1.208,1.802,1.208,3.104c0,0.384-0.057,0.736-0.172,1.059c-0.115,0.321-0.265,0.629-0.449,0.92c-0.184,0.291-0.391,0.563-0.621,0.816s-0.46,0.494-0.69,0.725c-0.399,0.429-0.759,0.839-1.081,1.23c-0.322,0.391-0.483,0.809-0.483,1.253v0.553H297.269z M297.959,24.192c-0.215-0.092-0.406-0.226-0.575-0.402c-0.169-0.176-0.299-0.376-0.391-0.598c-0.092-0.223-0.138-0.456-0.138-0.702c0-0.245,0.046-0.479,0.138-0.701c0.092-0.222,0.222-0.418,0.391-0.587c0.168-0.168,0.364-0.306,0.586-0.413c0.222-0.107,0.472-0.161,0.748-0.161c0.552,0,1.004,0.188,1.357,0.563c0.353,0.376,0.529,0.809,0.529,1.299c0,0.491-0.176,0.924-0.529,1.3c-0.353,0.376-0.805,0.563-1.357,0.563C298.442,24.354,298.189,24.3,297.959,24.192z"></path></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 16.666666666666664%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 111" enable-background="0 0 666 111" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 109.7213 21.7755)" font-family="'InterFace-Regular'" font-size="14px">High certainty of an overall survival benefit and reduced risk of</text><text transform="matrix(1 0 0 1 109.7213 38.575500000000005)" font-family="'InterFace-Regular'" font-size="14px">kidney failure, moderate certainty of important reductions in</text><text transform="matrix(1 0 0 1 109.7213 55.3755)" font-family="'InterFace-Regular'" font-size="14px">cardiovascular mortality and outcomes, and moderate certainty of no</text><text transform="matrix(1 0 0 1 109.7213 72.1755)" font-family="'InterFace-Regular'" font-size="14px">important increase in the risk of harms led to a strong recommendation</text><text transform="matrix(1 0 0 1 109.7213 88.97550000000001)" font-family="'InterFace-Regular'" font-size="14px">in favour</text></svg></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Potential benefits</text></svg></div></h2><div class="pane-content" style="padding: 0px 0px 10px 0px; max-width: 666px; margin: 0px auto 0px auto;"><div style="clear: both;"></div><div class="scaling-svg-container" style="padding-bottom: 11.562%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 60" enable-background="0 0 666 60" xml:space="preserve" style="width: 100%;"><polygon fill="#00B2A9" points="256.718,43.109 66.888,43.109 54.888,30.943 66.888,18.776 256.718,18.776 243.718,30.943"></polygon><text transform="matrix(1 0 0 1 157.389 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No SGLT-2 inhibitors</text><polygon fill="#765FA8" points="407.721,18.776 597.551,18.776 609.551,30.943 597.551,43.109 407.721,43.109 419.721,30.943"></polygon><text transform="matrix(1 0 0 1 511.128 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">SGLT-2 inhibitors</text><g class="thishasatooltip"><polygon fill="#7C8696" points="403.351,43.109 260.522,43.109 248.522,30.943 260.522,18.776 403.351,18.776 415.351,30.943"></polygon><text transform="matrix(1 0 0 1 332.32 34.4258)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No important difference</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="395.241" cy="18.088" r="6"></circle><path fill="#FFFFFF" d="M395.751,20.48c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L395.751,20.48z M395.999,15.877c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C396.877,15.486,396.484,15.877,395.999,15.877z"></path><g transform="matrix(1 0 0 1 365 5)" class="thisisthetooltip"><path opacity="0.8" enable-background="new " d="M-349.979,51.675c-5.6,0-10.1-4.5-10.1-10.1V10.211c0-5.6,4.5-10.1,10.1-10.1H11.135c5.6,0,10.1,4.5,10.1,10.1v5.2l10,10l-10,10v6.264c0,5.6-4.5,10.1-10.1,10.1L-349.979,51.675z"></path><text transform="matrix(1 0 0 1 -353.0981 16.7624)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">The panel found that this difference was not important for most patients,</tspan><tspan x="0" y="13" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">because the intervention effects were negligible and/or very imprecise, for</tspan><tspan x="0" y="26" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">example confidence intervals that include both important benefit and harm</tspan></text></g></g></svg></div><div class="scaling-svg-container" style="padding-bottom: 3.003%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 20" enable-background="0 0 666 20" xml:space="preserve" style="width: 100%;"><text transform="matrix(0.9746 0 0 1 14.0746 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Benefits</text><path fill="none" stroke="#7C8696" stroke-miterlimit="10" d="M441.083,17.13c0,0,0-1.791,0-3.98s-2.122-3.98-4.716-3.98H189.049c-2.594,0-4.716,1.791-4.716,3.98s0,3.98,0,3.98"></path><rect x="210.591642578125" y="5" fill="#C1D3E9" width="204.03271484375" height="8"></rect><text transform="matrix(0.9746 0 0 1 312.608 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">Events per 1000 people over 5 years</text><text transform="matrix(0.9746 0 0 1 488.304 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Evidence quality</text></svg></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">All-cause mortality</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">48 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">323</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">275</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="271.0919494628906" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 28 981 patients in 11 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors decrease all-cause</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">mortality</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" stroke="#FFFFFF" 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d="M-309.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-309.8,69-310,68.9-309.9,68.7z"></path><path fill="#FFFFFF" d="M-201,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-200.9,69-201.1,68.9-201,68.7z"></path><path fill="#FFFFFF" d="M-190.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-190,69-190.3,68.9-190.2,68.7z"></path><path fill="#FFFFFF" d="M-179.4,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-179.2,69-179.4,68.9-179.4,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Cardiovascular mortality</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">10 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">64</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">54</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 27 429 patients in 7 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">cardiovascular mortality</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" 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d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Kidney failure</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">58 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">181</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">123</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">High</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#EEAA1F" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 28 221 patients in 9 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors decrease kidney</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">failure</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">High</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(390.29061698913574,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(475.29061698913574,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-23.709383010864258,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" 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transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Non-fatal myocardial infarction</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">32 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">127</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">95</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 16 049 patients in 4 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">non-fatal myocardial infarction</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Non-fatal stroke</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">25 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">93</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">68</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 16 049 patients in 4 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">non-fatal stroke</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-309.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-309.8,69-310,68.9-309.9,68.7z"></path><path fill="#FFFFFF" d="M-201,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-200.9,69-201.1,68.9-201,68.7z"></path><path fill="#FFFFFF" d="M-190.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-190,69-190.3,68.9-190.2,68.7z"></path><path fill="#FFFFFF" d="M-179.4,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-179.2,69-179.4,68.9-179.4,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Admission for heart failure</text><polygon fill="#765FA8" points="318.227,15 440.227,15 447.227,7.5 440.227,0 318.227,0"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 323.2949 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="start">25 fewer</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">79</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#FFFFFF">54</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" 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29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 26 962 patients in 6 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably decrease</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">hospital admission for heart failure</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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font-size="12.2883px">Patient decision aids</text><circle fill="#057482" cx="9.6" cy="8.867" r="6.9"></circle><polygon fill="#FFFFFF" points="7.687,12.367 7.687,5.267 13.887,8.767 "></polygon><g transform="translate(19.108840942382812,-17.15)"><rect x="174.277" y="20.171" fill="#057482" width="20.823" height="11.301"></rect><path fill="#057482" 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fill="#FFFFFF" d="M186.463,26.7c-0.08,0.359-0.209,0.648-0.385,0.866c-0.178,0.22-0.409,0.376-0.699,0.468c-0.289,0.095-0.643,0.139-1.06,0.139h-0.173c-0.058,0-0.117-0.003-0.172-0.008v1.562h-1.284v-6.002c0,0,0.632-0.541,2.322-0.541c0.265,0,0.496,0.036,0.696,0.112c0.198,0.072,0.363,0.195,0.491,0.362c0.128,0.167,0.225,0.39,0.289,0.668s0.095,0.629,0.095,1.047C186.583,25.898,186.544,26.341,186.463,26.7z M185.155,24.509c-0.05-0.086-0.111-0.147-0.19-0.178c-0.077-0.034-0.173-0.048-0.29-0.048c-0.211,0-0.701,0.095-0.701,0.268v2.505c0.069,0.006,0.139,0.012,0.211,0.014c0.07,0.006,0.136,0.006,0.2,0.006c0.181,0,0.329-0.02,0.445-0.064c0.114-0.039,0.206-0.12,0.273-0.239c0.07-0.12,0.114-0.284,0.139-0.493c0.029-0.206,0.039-0.479,0.039-0.813c0-0.242-0.008-0.443-0.028-0.596C185.236,24.715,185.202,24.596,185.155,24.509z"></path><path fill="#FFFFFF" d="M181.393,27.772c0,0-0.682,0.37-1.974,0.37c-0.893,0-1.782-0.543-1.782-1.534c0-0.576,0.187-1.612,2.019-1.612h0.389V24.84c0-0.184-0.025-0.326-0.117-0.423c-0.092-0.097-0.242-0.147-0.481-0.147c-0.273,0-0.526,0.019-0.758,0.061c-0.128,0.022-0.259,0.05-0.387,0.081c-0.056,0.014-0.162,0.028-0.162,0.042v-1.081c0,0,0.023-0.005,0.034-0.008c0.038-0.008,0.078-0.017,0.12-0.022c0.122-0.023,0.248-0.045,0.378-0.064c0.128-0.017,0.262-0.033,0.401-0.042c0.133-0.008,0.262-0.014,0.376-0.014c0.406,0,0.734,0.033,0.983,0.1c0.248,0.067,0.445,0.17,0.582,0.309s0.24,0.317,0.287,0.532c0.047,0.217,0.091,0.47,0.091,0.762L181.393,27.772L181.393,27.772z M178.748,26.606c0,0.365,0.301,0.565,0.699,0.565c0.376,0,0.585-0.095,0.593-0.1l0.005-0.012v-1.041c0,0-0.342-0.044-0.579-0.044C179.063,25.974,178.748,26.193,178.748,26.606z"></path><path fill="#FFFFFF" d="M191.45,26.7c-0.078,0.359-0.209,0.648-0.385,0.866c-0.175,0.22-0.409,0.376-0.699,0.468c-0.289,0.095-0.642,0.139-1.06,0.139h-0.173c-0.058,0-0.114-0.003-0.172-0.008v1.562h-1.281v-6.002c0,0,0.632-0.541,2.323-0.541c0.262,0,0.492,0.036,0.692,0.112c0.198,0.072,0.362,0.195,0.491,0.362c0.127,0.167,0.225,0.39,0.289,0.668s0.098,0.629,0.098,1.047C191.572,25.898,191.53,26.341,191.45,26.7z M190.141,24.509c-0.05-0.086-0.111-0.147-0.19-0.178c-0.076-0.034-0.173-0.048-0.289-0.048c-0.211,0-0.701,0.095-0.701,0.268v2.505c0.07,0.006,0.142,0.012,0.211,0.014c0.07,0.006,0.14,0.006,0.203,0.006c0.178,0,0.326-0.02,0.443-0.064c0.114-0.039,0.206-0.12,0.273-0.239c0.069-0.12,0.114-0.284,0.142-0.493c0.025-0.206,0.039-0.479,0.039-0.813c0-0.242-0.011-0.443-0.03-0.596C190.222,24.715,190.189,24.596,190.141,24.509z"></path></g></svg></div></a><div class="scaling-svg-container" style="padding-bottom: 5.045045045045046%; max-width: 666px; margin: 15px auto 0px auto; clear: both;"><svg version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 33.6" enable-background="0 0 666 33.6" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 15.0713 20.0906)" fill="#000000" font-family="'InterFace-Regular'" font-size="14px">See below for summary of harms</text></svg></div><div style="clear:both;"></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Individual considerations</text></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 20%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 133.2" enable-background="0 0 666 133.2" xml:space="preserve" style="width: 100%;"><rect fill="#FFFFFF" x="16.5" y="16.471" width="633" height="111.19999999999999" rx="12" ry="12"></rect><path fill="#2A6EBB" d="M16.5,46.419V28.471c0-6.6,5.4-12,12-12h609c6.6,0,12,5.4,12,12v17.948"></path><text transform="matrix(1 0 0 1 333 36)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Values and preferences</text><text transform="matrix(1 0 0 1 125 70)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">The panel inferred that all or almost all individuals would be inclined to receive</text><text transform="matrix(1 0 0 1 125 84.4)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">SGLT-2 inhibitors, given benefits substantially outweigh possible harms. No</text><text transform="matrix(1 0 0 1 125 98.80000000000001)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">significant variability in patient preference was anticipated</text></svg></div></div></div></div></div><div class="whiteBox" style="margin:15px; padding:10px; background-color: #FFF; border-radius: 12px;"><div class="scaling-svg-container" style="padding-bottom: 11.223%; max-width: 695px; margin: 0px auto 0px auto"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 695 78" enable-background="0 0 695 78" xml:space="preserve" style="width: 100%;"><text transform="matrix(1 0 0 1 55.1034 36.7349)" fill="#333333" font-family="'InterFace-Bold'" font-size="21px">Harms (all patients)</text><path fill="#eb6467" stroke-width="0" d="M33.409,17.725c.609-1.055,1.605-1.055,2.214,0l11.517,19.947c.609,1.055.111,1.917-1.107,1.917h-23.033c-1.218,0-1.716-.863-1.107-1.917l11.517-19.947Z"></path><polygon fill="#fff" stroke-width="0" points="24.875 37.228 34.516 20.531 44.156 37.228 24.875 37.228"></polygon><path fill="#454444" stroke-width="0" d="M33.771,29.832c-.145-1.039-.261-1.916-.349-2.629-.088-.713-.132-1.233-.132-1.559s.111-.605.333-.838c.222-.233.52-.349.892-.349s.669.116.892.349c.222.233.333.512.333.838s-.044.845-.132,1.559c-.088.713-.204,1.59-.349,2.629-.145,1.039-.253,1.895-.326,2.567h-.838c-.072-.672-.181-1.528-.326-2.567ZM33.671,35.431c-.233-.233-.349-.514-.349-.845s.116-.613.349-.845c.233-.233.514-.349.845-.349s.613.116.845.349c.233.233.349.515.349.845s-.116.613-.349.845c-.233.233-.515.349-.845.349s-.613-.116-.845-.349Z"></path></svg></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Applicable across risk levels</text></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 14.03903903903904%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 93.5" enable-background="0 0 666 93.5" xml:space="preserve" style="width: 100%;"><rect x="125" y="10" fill="#FFFFFF" width="400" height="63.5" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 135 33)" fill="#000000" font-family="'InterFace-Regular'" font-size="12px">Harm outcomes were not risk-stratified. To reflect the uncertainty in</text><text transform="matrix(1 0 0 1 135 47.5)" fill="#000000" font-family="'InterFace-Regular'" font-size="12px">using unstratified absolute effect estimates, certainty in evidence was</text><text transform="matrix(1 0 0 1 135 62)" fill="#000000" font-family="'InterFace-Regular'" font-size="12px">rated down for indirectness in baseline risks</text></svg></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Potential harms</text></svg></div></h2><div class="pane-content" style="padding: 0px 0px 10px 0px; max-width: 666px; margin: 0px auto 0px auto;"><div style="clear: both;"></div><div class="scaling-svg-container" style="padding-bottom: 11.562%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 60" enable-background="0 0 666 60" xml:space="preserve" style="width: 100%;"><polygon fill="#00B2A9" points="256.718,43.109 66.888,43.109 54.888,30.943 66.888,18.776 256.718,18.776 243.718,30.943"></polygon><text transform="matrix(1 0 0 1 157.389 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No SGLT-2 inhibitors</text><polygon fill="#765FA8" points="407.721,18.776 597.551,18.776 609.551,30.943 597.551,43.109 407.721,43.109 419.721,30.943"></polygon><text transform="matrix(1 0 0 1 511.128 33.5013)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">SGLT-2 inhibitors</text><g class="thishasatooltip"><polygon fill="#7C8696" points="403.351,43.109 260.522,43.109 248.522,30.943 260.522,18.776 403.351,18.776 415.351,30.943"></polygon><text transform="matrix(1 0 0 1 332.32 34.4258)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">No important difference</text><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="395.241" cy="18.088" r="6"></circle><path fill="#FFFFFF" d="M395.751,20.48c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L395.751,20.48z M395.999,15.877c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C396.877,15.486,396.484,15.877,395.999,15.877z"></path><g transform="matrix(1 0 0 1 365 5)" class="thisisthetooltip"><path opacity="0.8" enable-background="new " d="M-349.979,51.675c-5.6,0-10.1-4.5-10.1-10.1V10.211c0-5.6,4.5-10.1,10.1-10.1H11.135c5.6,0,10.1,4.5,10.1,10.1v5.2l10,10l-10,10v6.264c0,5.6-4.5,10.1-10.1,10.1L-349.979,51.675z"></path><text transform="matrix(1 0 0 1 -353.0981 16.7624)" enable-background="new "><tspan x="0" y="0" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">The panel found that this difference was not important for most patients,</tspan><tspan x="0" y="13" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">because the intervention effects were negligible and/or very imprecise, for</tspan><tspan x="0" y="26" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">example confidence intervals that include both important benefit and harm</tspan></text></g></g></svg></div><div class="scaling-svg-container" style="padding-bottom: 3.003%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 20" enable-background="0 0 666 20" xml:space="preserve" style="width: 100%;"><text transform="matrix(0.9746 0 0 1 14.0746 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Harms</text><path fill="none" stroke="#7C8696" stroke-miterlimit="10" d="M441.083,17.13c0,0,0-1.791,0-3.98s-2.122-3.98-4.716-3.98H189.049c-2.594,0-4.716,1.791-4.716,3.98s0,3.98,0,3.98"></path><rect x="210.591642578125" y="5" fill="#C1D3E9" width="204.03271484375" height="8"></rect><text transform="matrix(0.9746 0 0 1 312.608 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">Events per 1000 people over 5 years</text><text transform="matrix(0.9746 0 0 1 488.304 13.5564)" font-family="'InterFace-Bold'" font-size="12.2883px">Evidence quality</text></svg></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Kidney injury requiring dialysis</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">23</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">14</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="255.65357971191406" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 8701 patients in 2 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably have little</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">or no effect on acute kidney injury</tspan><tspan x="0" y="29.492" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">requiring dialysis</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" stroke="#FFFFFF" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Lower limb amputation</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">29</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">31</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Low</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#FAE5BC" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 26 763 patients in 7 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors may have little or no</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">effect on lower limb amputation</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Low</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(387.4285469055176,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(472.4285469055176,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#7C8696" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(-26.571453094482422,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-309.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-309.8,69-310,68.9-309.9,68.7z"></path><path fill="#FFFFFF" d="M-201,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-200.9,69-201.1,68.9-201,68.7z"></path><path fill="#FFFFFF" d="M-190.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-190,69-190.3,68.9-190.2,68.7z"></path><path fill="#FFFFFF" d="M-179.4,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-179.2,69-179.4,68.9-179.4,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Ketoacidosis</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">3</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">7</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 26 912 patients in 6 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably have little</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">or no effect on ketoacidosis</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Fracture</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">91</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">93</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="271.0919494628906" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 29 276 patients in 12 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably have little</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">or no effect on fracture</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Genital infection</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">16</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">43</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="271.0919494628906" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 29 597 patients in 13 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably have little</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">or no effect on genital infections</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div class="accordion-group" style="padding: 1px 10px 1px 10px;"><h2 class="accord-title rr-graphic-title"><div class="scaling-svg-container" style="padding-bottom: 2.392%; max-width: 627px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 627 15" enable-background="0 0 627 15" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M619.867,15H7.133C3.21,15,0,11.79,0,7.867l0-0.735C0,3.21,3.21,0,7.133,0l612.735,0C623.79,0,627,3.21,627,7.133v0.735C627,11.79,623.79,15,619.867,15z"></path><text transform="matrix(1 0 0 1 8.2104 11.2426)" font-family="'InterFace-Regular'" font-size="12.2883px">Symptomatic hypovolemia</text><polygon fill="#7C8696" points="399.412,15 228.588,15 221.588,7.5 228.588,0 399.412,0 405.412,7.5"></polygon><text fill="#FFFFFF" transform="matrix(1 0 0 1 315.11 11.1465)" font-family="'InterFace-Bold'" font-size="12.2883px" text-anchor="middle">No important difference</text><text transform="matrix(1 0 0 1 183.4097 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#00B2A9">111</text><text transform="matrix(1 0 0 1 439.877 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px" text-anchor="end" fill="#765FA8">143</text><text transform="matrix(1 0 0 1 514.752 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">Moderate</text><path fill="#EEAA1F" d="M469.116,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C469.287,11.862,469.048,11.689,469.116,11.482z"></path><path fill="#EEAA1F" d="M479.953,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C480.124,11.862,479.885,11.689,479.953,11.482z"></path><path fill="#EEAA1F" d="M490.79,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C490.96,11.862,490.722,11.689,490.79,11.482z"></path><path fill="#FAE5BC" d="M501.627,11.482l2.641-8.073c0.068-0.207,0.36-0.207,0.427,0l2.633,8.06c0.068,0.207-0.17,0.38-0.346,0.251l-6.86-5.005c-0.176-0.128-0.085-0.406,0.133-0.406h8.418c0.217,0,0.308,0.277,0.133,0.406l-6.831,5.019C501.797,11.862,501.559,11.689,501.627,11.482z"></path><text transform="matrix(1 0 0 1 582.915 11.1465)" font-family="'InterFace-Regular'" font-size="12.2883px">More</text><path d="M616.91,11.58c-0.155,0.155-0.402,0.155-0.556,0l-4.585-4.579c-0.155-0.155-0.155-0.408,0-0.563l1.026-1.019c0.155-0.155,0.402-0.155,0.557,0l3.281,3.281l3.281-3.281c0.155-0.155,0.402-0.155,0.557,0l1.026,1.019c0.155,0.155,0.155,0.408,0,0.563L616.91,11.58z"></path></svg></div></h2><div class="pane-content rr-outcome-pane" style="max-width: 601px; margin: 1px auto 10px auto; "><div class="scaling-svg-container" style="padding-bottom: 25.124792013311147%; max-width: 601px; margin: 1px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 601 151" enable-background="0 0 601 151" xml:space="preserve" style="width: 100%;"><rect x="21.128" y="14.34" fill="#B2E8E5" width="264.4617919921875" height="27.492"></rect><rect x="35.39" y="9.891" transform="matrix(0.7071 -0.7071 0.7071 0.7071 0.0658 35.9028)" fill="#B2E8E5" width="15.962" height="15.962"></rect><text transform="matrix(1 0 0 1 29.7787 31.3985)" font-family="'InterFace-Regular'" font-size="12.2883px">Based on data from 27 550 patients in 8 studies</text><g transform="translate(0,20)"><path fill="#C8CCD3" d="M308.8,33.9c6.1,0,11,4.9,11,11v31c0,6.1-4.9,11-11,11H33.1c-6.1,0-11-4.9-11-11v-31c0-6.1,4.9-11,11-11H308.8 M308.8,32.9H33.1c-6.6,0-12,5.4-12,12v31c0,6.6,5.4,12,12,12h275.7c6.6,0,12-5.4,12-12v-31C320.8,38.3,315.4,32.9,308.8,32.9L308.8,32.9z"></path><path fill="#A2A9B4" d="M84.1,87.9h-51c-6.6,0-12-5.4-12-12v-31c0-6.6,5.4-12,12-12h51"></path><ellipse fill="#FFFFFF" cx="53.544" cy="56.4" rx="17.417" ry="9.562"></ellipse><polygon fill="#FFFFFF" points="44.1,59.2 42,74 54.3,62.1"></polygon><text transform="translate(94.5221 48.6479)"><tspan x="0" y="0" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">SGLT-2 inhibitors probably have little</tspan><tspan x="0" y="14.746" fill="#1D1D1B" font-family="'InterFace-Regular'" font-size="12.2883px">or no effect on symptomatic hypovolemia</tspan></text></g><path fill="#F0AB00" opacity="0.3" d="M348.097,24.626v105.058c0,5.145,4.171,9.316,9.316,9.316h222.72c5.654,0,10.28-4.626,10.28-10.28V25.141c0-5.578-4.564-10.141-10.141-10.141h-67.026l-10-11.333l-10,11.333H357.723C352.429,15,348.097,19.332,348.097,24.626z"></path><text font-family="'InterFace-Bold'" font-size="12.2883px" transform="translate(361.0023 31.08)">Moderate</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(416.85326385498047,31.08)">GRADE rating,</text><text font-family="'InterFace-Regular'" font-size="12.2883px" transform="translate(501.85326385498047,31.08)">because of:</text><g transform="translate(0,0)"><path fill="#FFFFFF" d="M575.618,53.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,50.049,579.539,53.257,575.618,53.257z"></path><path fill="#EEAA1F" d="M447.413,53.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.9483" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Risk of bias</text><text x="452.58" y="49.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,72.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,69.049,579.539,72.257,575.618,72.257z"></path><path fill="#EEAA1F" d="M447.413,72.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.3677" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Imprecision</text><text x="452.58" y="68.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#7C8696" d="M575.618,91.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,88.049,579.539,91.257,575.618,91.257z"></path><path fill="#EEAA1F" d="M447.413,91.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.8648" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Indirectness</text><text x="452.58" y="87.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF">Serious</text><path fill="#FFFFFF" d="M575.618,110.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,107.049,579.539,110.257,575.618,110.257z"></path><path fill="#EEAA1F" d="M447.413,110.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.0801" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Inconsistency</text><text x="452.58" y="106.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text><path fill="#FFFFFF" d="M575.618,129.257h-210.66c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h210.66c3.921,0,7.128,3.208,7.128,7.128v0C582.747,126.049,579.539,129.257,575.618,129.257z"></path><path fill="#EEAA1F" d="M447.413,129.257h-82.455c-3.921,0-7.128-3.208-7.128-7.128v0c0-3.921,3.208-7.128,7.128-7.128h82.455"></path><text x="443.1461" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#FFFFFF" text-anchor="end">Publication bias</text><text x="452.58" y="125.6665" font-family="'InterFace-Regular'" font-size="12.2883px" fill="#1D1D1B">No serious concerns</text></g><g transform="translate(2.8532638549804688,0)" class="thishasatooltip"><circle fill="#2A6EBB" stroke="#FFFFFF" stroke-miterlimit="10" cx="488.795" cy="24.562" r="6"></circle><path fill="#FFFFFF" d="M489.304,26.954c-0.041,0.181-0.072,0.318-0.072,0.436c0,0.243,0.134,0.339,0.424,0.339c0.124,0,0.227-0.011,0.361-0.021l0.042,0.436c-0.465,0.243-0.899,0.371-1.395,0.371c-0.661,0-0.961-0.34-0.961-0.955c0-0.19,0.031-0.402,0.083-0.636l0.547-2.28c0.041-0.159,0.062-0.308,0.062-0.403c0-0.371-0.228-0.52-0.733-0.52l0.093-0.413c0.32-0.17,0.806-0.351,1.312-0.351c0.579,0,0.888,0.266,0.888,0.859c0,0.17-0.021,0.35-0.072,0.572L489.304,26.954z M489.552,22.351c-0.475,0-0.868-0.392-0.868-0.88c0-0.487,0.393-0.891,0.889-0.891c0.475,0,0.857,0.403,0.857,0.891C490.431,21.96,490.038,22.351,489.552,22.351z"></path><g class="thisisthetooltip" transform="translate(355,8)"><path opacity="0.8" enable-background="new " d="M-355.7,43.6c0-5.6,4.5-10.1,10.1-10.1H123l10-10l10,10h49.5c5.6,0,10.1,4.5,10.1,10.1v82.2c0,5.6-4.5,10.1-10.1,10.1h-538c-5.6,0-10.1-4.5-10.1-10.1L-355.7,43.6z"></path><text transform="matrix(0.9746 0 0 1 -134.5737 47.909)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">GRADE certainty ratings</text><text transform="matrix(0.9746 0 0 1 -297.9473 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">High</text><text transform="matrix(0.9746 0 0 1 -344.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors have a lot of</text><text transform="matrix(0.9746 0 0 1 -344.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">confidence that the true</text><text transform="matrix(0.9746 0 0 1 -344.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">effect is similar to the</text><text transform="matrix(0.9746 0 0 1 -344.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -156.0044 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Moderate</text><text transform="matrix(0.9746 0 0 1 -202.6631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The authors believe that</text><text transform="matrix(0.9746 0 0 1 -202.6631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the true effect is probably</text><text transform="matrix(0.9746 0 0 1 -202.6631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">close to the</text><text transform="matrix(0.9746 0 0 1 -202.6631 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><text transform="matrix(0.9746 0 0 1 -5.6768 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Low</text><text transform="matrix(0.9746 0 0 1 -53.1631 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect might be</text><text transform="matrix(0.9746 0 0 1 -53.1631 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">markedly different from</text><text transform="matrix(0.9746 0 0 1 -53.1631 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">the estimated effect</text><text transform="matrix(0.9746 0 0 1 137.7656 68.6673)" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12.2883px">Very low</text><text transform="matrix(0.9746 0 0 1 91.3369 84.9095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">The true effect is</text><text transform="matrix(0.9746 0 0 1 91.3369 98.1097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">probably markedly</text><text transform="matrix(0.9746 0 0 1 91.3369 111.4095)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">different from the</text><text transform="matrix(0.9746 0 0 1 91.3369 124.6097)" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12.2883px">estimated effect</text><line fill="none" 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d="M-168.5,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-168.4,69-168.6,68.9-168.5,68.7z"></path><path fill="#FFFFFF" d="M-50.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-50.5,69-50.8,68.9-50.7,68.7z"></path><path fill="#FFFFFF" d="M-39.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-39.7,69-39.9,68.9-39.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-29,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.5c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-28.9,69-29.1,68.9-29,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M-18.2,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C-18,69-18.3,68.9-18.2,68.7z"></path><path fill="#FFFFFF" d="M93,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C93.2,69,93,68.9,93,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M103.9,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C104.1,69,103.8,68.9,103.9,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M114.7,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C114.9,69,114.7,68.9,114.7,68.7z"></path><path opacity="0.3" fill="#FFFFFF" enable-background="new " d="M125.6,68.7l2.6-8.1c0.1-0.2,0.4-0.2,0.4,0l2.6,8.1c0.1,0.2-0.2,0.4-0.3,0.3l-6.9-5c-0.2-0.1-0.1-0.4,0.1-0.4h8.4c0.2,0,0.3,0.3,0.1,0.4l-6.8,5C125.7,69,125.5,68.9,125.6,68.7z"></path></g></g></svg></div></div></div><div style="clear:both;"></div></div></div></div><div class="dropdown-background" style="border-radius: 20px; max-width: 666px; margin: 0px auto 10px auto;"><div class="accordion-group"><h2 class="dropdown-title accord-title" style="border-radius: 20px; margin:0px;"><div class="scaling-svg-container" style="padding-bottom: 5.105%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 34" enable-background="0 0 666 34" xml:space="preserve" style="width: 100%;"><path fill="#FFFFFF" d="M643.96,21.985c-0.25,0.25-0.65,0.25-0.901,0l-7.42-7.41c-0.25-0.25-0.25-0.66,0-0.911l1.66-1.649c0.25-0.25,0.65-0.25,0.901,0l5.31,5.31l5.31-5.31c0.25-0.25,0.65-0.25,0.901,0l1.66,1.649c0.25,0.25,0.25,0.66,0,0.911L643.96,21.985z"></path><text transform="matrix(1 0 0 1 333 21.7755)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Individual considerations</text></svg></div></h2><div class="pane-content" style="padding: 10px; max-width: 666px; margin: 0px auto 0px auto;"><div class="scaling-svg-container" style="padding-bottom: 84.08408408408408%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 560" enable-background="0 0 666 560" xml:space="preserve" style="width: 100%;"><rect fill="#FFFFFF" x="16.5" y="16.471" width="633" height="538" rx="12" ry="12"></rect><path fill="#2A6EBB" d="M16.5,46.419V28.471c0-6.6,5.4-12,12-12h609c6.6,0,12,5.4,12,12v17.948"></path><text transform="matrix(1 0 0 1 333 36)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Key practical issues</text><text transform="matrix(1 0 0 1 330 67)" text-anchor="middle" font-family="'InterFace-Bold'" font-size="15px">SGLT-2 inhibitors</text><rect x="16.5" y="79" fill="#5a8ac7" width="633" height="17.846"></rect><text transform="matrix(1 0 0 1 333 92)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12px">Practical considerations</text><rect x="130" y="102" fill="#765FA8" width="400" height="33" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 115)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">SGLT-2 inhibitors may be initiated at the highest possible dose and do not</text><text transform="matrix(1 0 0 1 330 128)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">require dose titration</text><rect x="130" y="140" fill="#765FA8" width="400" height="33" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 153)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">SGLT-2 inhibitors may be initiated in adults with estimated GFR ≥ 20 ml/min</text><text transform="matrix(1 0 0 1 330 166)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">per 1.73 m²</text><rect x="130" y="178" fill="#765FA8" width="400" height="33" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 191)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">Once initiated, SGLT-2 inhibitors may be continued even if estimated GFR <</text><text transform="matrix(1 0 0 1 330 204)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">20 ml/min per 1.73 m² until dialysis initiation</text><rect x="130" y="216" fill="#765FA8" width="400" height="59" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 229)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">While SGLT-2 inhibitors are likely to cause a transient decline in GFR shortly</text><text transform="matrix(1 0 0 1 330 242)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">after initiation, routine kidney function monitoring is not warranted except in</text><text transform="matrix(1 0 0 1 330 255)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">higher risk individuals (for example people with prior acute kidney injury or</text><text transform="matrix(1 0 0 1 330 268)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">risk of volume depletion)</text><rect x="130" y="280" fill="#765FA8" width="400" height="46" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 293)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">A transient decline in GFR should not be a reason to discontinue therapy</text><text transform="matrix(1 0 0 1 330 306)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">unless it exceeds 25% from baseline. If discontinued, therapy should be</text><text transform="matrix(1 0 0 1 330 319)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">re-initiated after recovery of kidney function</text><rect x="130" y="331" fill="#765FA8" width="400" height="46" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 344)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">Individuals taking diuretics or otherwise at risk of volume depletion may</text><text transform="matrix(1 0 0 1 330 357)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">require closer monitoring and diuretic titration when initiating SGLT-2</text><text transform="matrix(1 0 0 1 330 370)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">inhibitors</text><rect x="130" y="382" fill="#765FA8" width="400" height="33" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 395)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">SGLT-2 inhibitors are recommended in individuals with concomitant heart</text><text transform="matrix(1 0 0 1 330 408)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">failure, irrespective of kidney function and degree of albuminuria</text><rect x="16.5" y="425" fill="#5a8ac7" width="633" height="17.846"></rect><text transform="matrix(1 0 0 1 333 438)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="12px">Counselling to patients</text><rect x="130" y="448" fill="#765FA8" width="400" height="46" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 461)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">Advise patients about potential adverse events, including genital mycotic</text><text transform="matrix(1 0 0 1 330 474)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">infections, acute kidney injury, fractures, euglycaemic ketoacidosis, volume</text><text transform="matrix(1 0 0 1 330 487)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">depletion, Fournier's gangrene and amputations</text><rect x="130" y="499" fill="#765FA8" width="400" height="46" rx="8" ry="8"></rect><text transform="matrix(1 0 0 1 330 512)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">Advise patients about temporarily stopping medication when unwell,</text><text transform="matrix(1 0 0 1 330 525)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">engaging in prolonged fasting, undergoing surgery or suffering from severe</text><text transform="matrix(1 0 0 1 330 538)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Regular'" font-size="12px">gastrointestinal losses such as diarrhoea or vomiting (sick day counselling)</text></svg></div><div class="scaling-svg-container" style="padding-bottom: 22.16216216216216%; max-width: 666px; margin: 0px auto 0px auto;"><svg class="scaling-svg" version="1.1" xmlns="https://www.w3.org/2000/svg" xmlns:xlink="https://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 666 147.6" enable-background="0 0 666 147.6" xml:space="preserve" style="width: 100%;"><rect fill="#FFFFFF" x="16.5" y="16.471" width="633" height="125.6" rx="12" ry="12"></rect><path fill="#2A6EBB" d="M16.5,46.419V28.471c0-6.6,5.4-12,12-12h609c6.6,0,12,5.4,12,12v17.948"></path><text transform="matrix(1 0 0 1 333 36)" text-anchor="middle" fill="#FFFFFF" font-family="'InterFace-Bold'" font-size="15px">Resources and availability</text><text transform="matrix(1 0 0 1 125 70)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">SGLT-2 inhibitors are widely available internationally. Most SGLT-2 inhibitors are</text><text transform="matrix(1 0 0 1 125 84.4)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">available as once-daily oral regimens. Individuals initiating SGLT-2 inhibitors</text><text transform="matrix(1 0 0 1 125 98.80000000000001)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">require counselling regarding possibility of adverse events and sick day</text><text transform="matrix(1 0 0 1 125 113.20000000000002)" text-anchor="start" font-family="'InterFace-Regular'" font-size="12px">counselling</text></svg></div></div></div></div></div></div> <p style="margin: 15px 0px 0px 0px;">©BMJ Publishing Group Limited.</p> <p style="font-size:10px;">Disclaimer: This infographic is not a validated clinical decision aid. This information is provided without any representations, conditions or warranties that it is accurate or up to date. BMJ and its licensors assume no responsibility for any aspect of treatment administered with the aid of this information. Any reliance placed on this information is strictly at the user's own risk. 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Please see:</h3><ul class="highwire-corrections-list"><li class="relation-2661027 first last"><a href="/content/387/bmj.q2605">Sodium-glucose cotransporter-2 (SGLT-2) inhibitors for adults with chronic kidney disease: a clinical practice guideline - November 21, 2024</a></li> </ul></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-markup" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article fulltext-view "><span class="highwire-journal-article-marker-start"></span><div class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Arnav Agarwal</span><span class="contrib-role">, internist, methods co-chair</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">2</a><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">3</a><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">4</a><a id="xref-aff-22-1" class="xref-aff" href="#aff-22">*</a>, </li><li class="contributor" id="contrib-2"><span class="name">Xiaoxi Zeng</span><span class="contrib-role">, nephrologist, methods co-chair trainee</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">1</a><a id="xref-aff-4-2" class="xref-aff" href="#aff-4">4</a><a id="xref-aff-22-2" class="xref-aff" href="#aff-22">*</a>, </li><li class="contributor" id="contrib-3"><span class="name">Sheyu Li</span><span class="contrib-role">, endocrinologist, methodologist</span><a id="xref-aff-5-1" class="xref-aff" href="#aff-5">5</a><a id="xref-aff-6-1" class="xref-aff" href="#aff-6">6</a>, </li><li class="contributor" id="contrib-4"><span class="name">Daniel Rayner</span><span class="contrib-role">, methodologist</span><a id="xref-aff-3-2" class="xref-aff" href="#aff-3">3</a>, </li><li class="contributor" id="contrib-5"><span class="name">Farid Foroutan</span><span class="contrib-role">, methodologist</span><a id="xref-aff-3-3" class="xref-aff" href="#aff-3">3</a><a id="xref-aff-4-3" class="xref-aff" href="#aff-4">4</a><a id="xref-aff-7-1" class="xref-aff" href="#aff-7">7</a>, </li><li class="contributor" id="contrib-6"><span class="name">Bert Aertgeerts</span><span class="contrib-role">, primary care physician</span><a id="xref-aff-8-1" class="xref-aff" href="#aff-8">8</a><a id="xref-aff-9-1" class="xref-aff" href="#aff-9">9</a>, </li><li class="contributor" id="contrib-7"><span class="name">Frederic Coyac</span><span class="contrib-role">, patient partner</span><a id="xref-aff-10-1" class="xref-aff" href="#aff-10">10</a>, </li><li class="contributor" id="contrib-8"><span class="name">Pauline Darbellay Farhoumand</span><span class="contrib-role">, internist</span><a id="xref-aff-11-1" class="xref-aff" href="#aff-11">11</a>, </li><li class="contributor" id="contrib-9"><span class="name">Andrew Demaine</span><span class="contrib-role">, patient partner</span><a id="xref-aff-12-1" class="xref-aff" href="#aff-12">12</a>, </li><li class="contributor" id="contrib-10"><span class="name">Anja Fog Heen</span><span class="contrib-role">, endocrinologist, methodologist</span><a id="xref-aff-4-4" class="xref-aff" href="#aff-4">4</a><a id="xref-aff-13-1" class="xref-aff" href="#aff-13">13</a>, </li><li class="contributor" id="contrib-11"><span class="name">Vivekanand Jha</span><span class="contrib-role">, nephrologist</span><a id="xref-aff-14-1" class="xref-aff" href="#aff-14">14</a><a id="xref-aff-15-1" class="xref-aff" href="#aff-15">15</a><a id="xref-aff-16-1" class="xref-aff" href="#aff-16">16</a>, </li><li class="contributor" id="contrib-12"><span class="name">Edward Machuve</span><span class="contrib-role">, patient partner</span><a id="xref-aff-10-2" class="xref-aff" href="#aff-10">10</a>, </li><li class="contributor" id="contrib-13"><span class="name">Evi Nagler</span><span class="contrib-role">, nephrologist</span><a id="xref-aff-17-1" class="xref-aff" href="#aff-17">17</a>, </li><li class="contributor" id="contrib-14"><span class="name">David J Tunnicliffe</span><span class="contrib-role">, methodologist</span><a id="xref-aff-18-1" class="xref-aff" href="#aff-18">18</a><a id="xref-aff-19-1" class="xref-aff" href="#aff-19">19</a>, </li><li class="contributor" id="contrib-15"><span class="name">Gordon H Guyatt</span><span class="contrib-role">, internist, methodologist</span><a id="xref-aff-2-2" class="xref-aff" href="#aff-2">2</a><a id="xref-aff-3-4" class="xref-aff" href="#aff-3">3</a><a id="xref-aff-4-5" class="xref-aff" href="#aff-4">4</a>, </li><li class="contributor" id="contrib-16"><span class="name">Per Olav Vandvik</span><span class="contrib-role">, internist, methodologist</span><a id="xref-aff-4-6" class="xref-aff" href="#aff-4">4</a><a id="xref-aff-20-1" class="xref-aff" href="#aff-20">20</a>, </li><li class="contributor" id="contrib-17"><span class="name">Belen Ponte</span><span class="contrib-role">, nephrologist, clinical co-chair</span><a id="xref-aff-21-1" class="xref-aff" href="#aff-21">21</a><a id="xref-aff-23-1" class="xref-aff" href="#aff-23">†</a>, </li><li class="last" id="contrib-18"><span class="name">Thomas Agoritsas</span><span class="contrib-role">, internist, methodologist</span><a id="xref-aff-3-5" class="xref-aff" href="#aff-3">3</a><a id="xref-aff-4-7" class="xref-aff" href="#aff-4">4</a><a id="xref-aff-11-2" class="xref-aff" href="#aff-11">11</a><a id="xref-aff-23-2" class="xref-aff" href="#aff-23">†</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>1</sup>Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China, 610041</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>2</sup>Department of Medicine, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>3</sup>Department of Health Research Methods, Evidence and Impact, HSC 2C, Hamilton, Ontario, Canada, L8S 4L8</address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>4</sup>MAGIC Evidence Ecosystem Foundation, Oslo, Norway, 0282</address></li><li class="aff"><a id="aff-5" name="aff-5"></a><address><sup>5</sup>Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China, 610041</address></li><li class="aff"><a id="aff-6" name="aff-6"></a><address><sup>6</sup>Chinese Evidence-Based Medicine Center, Cochrane China Center and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China, 610041</address></li><li class="aff"><a id="aff-7" name="aff-7"></a><address><sup>7</sup>Ted Rogers Center for Heart Research, Toronto, Ontario, Canada, M5G 1X8</address></li><li class="aff"><a id="aff-8" name="aff-8"></a><address><sup>8</sup>Academic Centre for General Practice, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium, 3000</address></li><li class="aff"><a id="aff-9" name="aff-9"></a><address><sup>9</sup>CEBAM, Belgian Centre for Evidence-Based Medicine, Cochrane Belgium, Leuven, Belgium, 3000.</address></li><li class="aff"><a id="aff-10" name="aff-10"></a><address><sup>10</sup>Geneva, Switzerland.</address></li><li class="aff"><a id="aff-11" name="aff-11"></a><address><sup>11</sup>Division of General Internal Medicine, Department of Medicine, Hôpitaux Universitaire de Genève and University of Geneva, Geneva, Switzerland, 1205</address></li><li class="aff"><a id="aff-12" name="aff-12"></a><address><sup>12</sup>Plymouth, United Kingdom.</address></li><li class="aff"><a id="aff-13" name="aff-13"></a><address><sup>13</sup>Department of Medicine, Lovisenberg Diaconal Hospital, Oslo, Norway, 0456</address></li><li class="aff"><a id="aff-14" name="aff-14"></a><address><sup>14</sup>George Institute for Global Health, Elegance Tower, Jasola District Centre, New Delhi, India, 110025.</address></li><li class="aff"><a id="aff-15" name="aff-15"></a><address><sup>15</sup>School of Public Health, Imperial College London, London, UK, SW7 2AZ</address></li><li class="aff"><a id="aff-16" name="aff-16"></a><address><sup>16</sup>Prasanna School of Public Health, Manipal Academy of Higher Education, Madhav Nagar, Eshwar Nagar, Manipal, Karnataka, India, 576104</address></li><li class="aff"><a id="aff-17" name="aff-17"></a><address><sup>17</sup>Department of Nephrology, Ghent University Hospital, Ghent, Belgium, 9000</address></li><li class="aff"><a id="aff-18" name="aff-18"></a><address><sup>18</sup>Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia, 2006</address></li><li class="aff"><a id="aff-19" name="aff-19"></a><address><sup>19</sup>Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia, 2145</address></li><li class="aff"><a id="aff-20" name="aff-20"></a><address><sup>20</sup>Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway, 2819</address></li><li class="aff"><a id="aff-21" name="aff-21"></a><address><sup>21</sup>Division of Nephrology and Hypertension, Department of Medicine, University of Geneva, University Hospitals of Geneva, Geneva, Switzerland, 1205</address></li><li class="aff"><a id="aff-22" name="aff-22"></a><address><sup>*</sup>. Both authors contributed equally (co-first authors)</address></li><li class="aff"><a id="aff-23" name="aff-23"></a><address><sup>†</sup>. Both authors contributed equally (co-last authors)</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Correspondence to: S Li <span class="em-link"><span class="em-addr">lisheyu{at}gmail.com</span></span>, B Ponte <span class="em-link"><span class="em-addr">belen.ponte{at}hug.ch</span></span>, T Agoritsas <span class="em-link"><span class="em-addr">thomas.agoritsas{at}unige.ch</span></span></li></ol></div><div class="section abstract" id="abstract-1"><h2 class="">Abstract</h2><div id="sec-1" class="subsection"><p id="p-1"><strong>Clinical question</strong> What is the impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on survival and on cardiovascular and kidney outcomes for adults living with chronic kidney disease (CKD)?</p></div><div id="sec-2" class="subsection"><p id="p-2"><strong>Current practice</strong> Few therapies slow kidney disease progression and improve long term prognosis for adults living with CKD. SGLT-2 inhibitors have demonstrated cardiovascular and kidney benefits in adults with CKD with and without type 2 diabetes. Existing guidance for SGLT-2 inhibitors does not account for the totality of current best evidence for adults with CKD and does not provide fully stratified treatment effects and recommendations across all risk groups based on risk of CKD progression and complications.</p></div><div id="sec-3" class="subsection"><p id="p-3"><strong>Recommendations</strong> The guideline panel considered evidence regarding benefits and harms of SGLT-2 inhibitor therapy for adults with CKD over a five year period, along with contextual factors, and provided the following recommendations:</p><p id="p-4">1. For adults at low risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour)</p><p id="p-5">2. For adults at moderate risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour)</p><p id="p-6">3. For adults at high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour)</p><p id="p-7">4. For adults at very high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour).</p><p id="p-8">Recommendations are applicable to all adults with CKD, irrespective of type 2 diabetes status.</p></div><div id="sec-4" class="subsection"><p id="p-9"><strong>How this guideline was created</strong> An international panel including patients, clinicians, and methodologists produced these recommendations following standards for trustworthy guidelines and using the GRADE approach. The panel identified typical risk strata of adults with CKD (from low to very high risk of CKD progression and related complications) using the classification system developed by Kidney Disease Improving Global Outcomes (KDIGO), and applied an individual patient perspective in moving from evidence to recommendations. Effects of SGLT-2 inhibitors were interpreted in absolute terms applicable to different risk strata with varying baseline risks for outcomes of benefit over a five year period. The panel explicitly considered the balance of benefits, harms, and burdens of starting an SGLT-2 inhibitor, incorporating the values and preferences of adults with different risk profiles. Interactive evidence summaries and decision aids accompany multilayered recommendations, developed in an online authoring and publication platform (<a href="http://www.magicapp.org">www.magicapp.org</a>) that allows reuse and adaptation.</p></div><div id="sec-5" class="subsection"><p id="p-10"><strong>The evidence</strong> A linked systematic review and pairwise meta-analysis (13 trials including 29 614 participants) of benefits and harms associated with SGLT-2 inhibitors in adults with CKD with or without type 2 diabetes informed guidance. Among individuals at very high risk of CKD progression and complications, moderate to high certainty evidence shows SGLT-2 inhibitors (relative to placebo or standard care without SGLT-2 inhibitors) decrease all-cause and cardiovascular mortality, hospitalisation for heart failure, kidney failure, non-fatal myocardial infarction, and non-fatal stroke. Among individuals at high risk, moderate to high certainty evidence shows SGLT-2 inhibitors result in similar benefits across outcomes except demonstrating little or no effect on hospitalisation for heart failure and kidney failure. Among individuals at moderate and low risk, moderate to high certainty evidence shows SGLT-2 inhibitors probably reduce all-cause mortality and non-fatal stroke, with little or no effect for other outcomes of benefit. Risk-stratified estimates were unavailable for outcomes of harm; the panel therefore considered absolute effects summarised across risk strata. SGLT-2 inhibitors are associated with little or no effect on acute kidney injury requiring dialysis, bone fractures, lower limb amputations, ketoacidosis, genital infections, or symptomatic hypovolaemia, although a residual possibility of harms at the individual patient level remains.</p></div><div id="sec-6" class="subsection"><p id="p-11"><strong>Understanding the recommendation</strong> In order to apply recommendations, clinicians must appropriately identify adults with CKD, consider the underlying aetiology, and risk stratify them based on glomerular filtration rate (estimated or measured) and degree of albuminuria. In addition to classifying individuals into risk strata, further estimation of a given patient’s risk based on the extent of their kidney disease and other comorbidities may be warranted to inform individual-level decisions and shared decision making. Available risk calculators may help estimate a given patient’s risk of CKD progression and complications.</p></div></div><div class="section other1" id="sec-7"><h2 class="">Why is the guideline needed?</h2><p id="p-12">Chronic kidney disease (CKD) is characterised by abnormalities of kidney structure or function, present for a minimum of three months, and is classified based on aetiology, glomerular filtration rate (GFR), and degree of albuminuria.<a id="xref-ref-1-1" class="xref-bibr" href="#ref-1">1</a> CKD affects approximately 850 million individuals internationally, is the tenth leading cause of death, and is projected to be the fifth leading cause by 2050.<a id="xref-ref-2-1" class="xref-bibr" href="#ref-2">2</a><a id="xref-ref-3-1" class="xref-bibr" href="#ref-3">3</a><a id="xref-ref-4-1" class="xref-bibr" href="#ref-4">4</a> Although clinical trajectories vary across individuals, CKD is generally progressive, with declining GFR and progressive albuminuria associated with an increasing risk of cardiovascular complications, kidney failure, and premature death.<a id="xref-ref-5-1" class="xref-bibr" href="#ref-5">5</a><a id="xref-ref-6-1" class="xref-bibr" href="#ref-6">6</a></p><p id="p-13">For a long time, therapies to slow progression of kidney disease and improve long term prognosis of adults living with CKD were lacking. Sodium-glucose co-transporter-2 (SGLT-2) inhibitors have emerged—alongside renin-angiotensin system inhibitors, glucagon-like peptide 1 agonists, and non-steroidal mineralocorticoid receptor antagonists—as therapies with potential cardiovascular and kidney protective effects among individuals with type 2 diabetes and CKD.<a id="xref-ref-7-1" class="xref-bibr" href="#ref-7">7</a> Recently, two randomised trials have demonstrated similar cardiovascular and kidney benefits with the use of SGLT-2 inhibitors among non-diabetic individuals with CKD at varying GFRs and degrees of albuminuria.<a id="xref-ref-8-1" class="xref-bibr" href="#ref-8">8</a><a id="xref-ref-9-1" class="xref-bibr" href="#ref-9">9</a></p><p id="p-14">Previous guidelines from Kidney Disease: Improving Global Outcomes (KDIGO) recommended the use of SGLT-2 inhibitors for patients with type 2 diabetes, CKD, and an estimated GFR of ≥20 mL/min per 1.73 m<sup>2</sup>.<a id="xref-ref-10-1" class="xref-bibr" href="#ref-10">10</a> Their more recent guidance provide recommendations for SGLT-2 inhibitors more broadly for adults with CKD irrespective of diabetes status; however, recommendations are limited to specific risk groups (that is, an estimated GFR ≥20 mL/min per 1.73 m<sup>2</sup> with urine albumin to creatinine ratio (ACR) ≥20 mg/mmol (≥200 mg/g) with concurrent heart failure; or with an estimated GFR 20-45 mL/min per 1.73 m<sup>2</sup> with urine ACR <20 mg/mmol).<a id="xref-ref-11-1" class="xref-bibr" href="#ref-11">11</a> Moreover, these recommendations are primarily informed by a systematic review and meta-analysis of large double-blind, placebo-controlled trials of at least six months duration evaluating SGLT-2 inhibitors across disease populations including CKD. The review included only four large trials including adults with CKD and did not account for the entirety of existing randomised trial evidence applicable to the CKD population. The review and practice guideline did not take into account treatment effects in absolute terms based on varying prognoses and baseline risks (that is, likelihood of events occurring without treatment), therefore failing to provide risk-stratified interpretations of the evidence and risk-stratified recommendations.<a id="xref-ref-11-2" class="xref-bibr" href="#ref-11">11</a><a id="xref-ref-12-1" class="xref-bibr" href="#ref-12">12</a></p><p id="p-15">We need trustworthy and actionable guidelines that consider all available randomised trial evidence regarding benefits and harms, translate evidence into absolute effects for patient-important outcomes over a reasonable timeframe, and provide risk-stratified recommendations that account for the variable prognoses of adults living with CKD. An international guideline panel involving diverse healthcare professionals, patient partners, and methodologists experienced in guideline development provides the basis for practice guidance that can be used, adapted, and widely implemented.<a id="xref-ref-13-1" class="xref-bibr" href="#ref-13">13</a></p><div class="boxed-text" id="boxed-text-1"><h3>Linked resources in this <em>BMJ</em> Rapid Recommendations cluster</h3><p id="p-16">Recommendations are informed by a systematic review and meta-analysis evaluating SGLT-2 inhibitors for adults with CKD, including individuals with and without type 2 diabetes. Summary of findings tables included in the guideline are directly informed by the systematic review.</p><p id="p-17">This guideline on SGLT-2 inhibitors for individuals with CKD parallels an ongoing living <em>BMJ</em> Rapid Recommendation on drugs for type 2 diabetes, informed by a living systematic review and network meta-analysis. The living diabetes guideline provides recommendations across varying degrees of cardiovascular and kidney risk profiles, and includes recommendations for SGLT-2 inhibitors in individuals with type 2 diabetes. Approaches to risk stratification and recommendations provided are harmonised between the two guidelines by the MAGIC Evidence Ecosystem Foundation (<a href="http://www.magicevidence.org">www.magicevidence.org</a>).</p><p id="p-18">This guideline, as well as the parallel living guideline on drugs for diabetes, contribute to the <em>BMJ</em> Rapid Recommendations series, focused on providing clinicians with trustworthy recommendations for potentially practice changing evidence. <em>BMJ</em> Rapid Recommendations represent a collaborative effort between MAGIC and <em>The BMJ</em>.<a id="xref-ref-19-1" class="xref-bibr" href="#ref-19">19</a> MAGICapp (<a href="http://www.magicapp.org">www.magicapp.org</a>) houses the full version of the guideline, including interactive decision aids, and is accessible across all devices in multilayered formats.<a id="xref-ref-20-1" class="xref-bibr" href="#ref-20">20</a> Readers can access an interactive version of this guideline with associated evidence summaries and interactive decision aids via MAGICapp (link below).</p><div id="sec-8" class="subsection"><h4>Linked resouces</h4><ul class="list-unord " id="list-1"><li id="list-item-1"><p id="p-19">Zou X, Shi Q, Vandvik P, et al. Sodium glucose co-transporter-2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes: a systematic review and meta-analysis. <em>BMJ Med</em> 2024;3:e001009, doi:<a href="/lookup/doi/10.1136/bmjmed-2024-001009">10.1136/bmjmed-2024-001009</a>.</p></li><li id="list-item-2"><p id="p-20">Agarwal A, Zeng X, Li S, et al. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors for adults with chronic kidney disease: a clinical practice guideline. <em>BMJ</em> 2024;386:e080257, doi:<a href="/lookup/doi/10.1136/bmj-2024-080257">10.1136/bmj-2024-080257</a></p></li><li id="list-item-3"><p id="p-21">MAGICapp: <a href="https://app.magicapp.org/#/guideline/EezrQj">https://app.magicapp.org/#/guideline/EezrQj</a></p></li></ul></div></div></div><div class="section other2" id="sec-9"><h2 class="">Context for recommendations</h2><p id="p-22">This practice guidance is intended to facilitate evidence-informed decision making for nephrologists, endocrinologists, internal medicine physicians, general practitioners, and patients with established CKD regardless of degree of kidney dysfunction and albuminuria. The recommendations take into account all available evidence regarding SGLT-2 inhibitors for adults with CKD; the expertise and experience of healthcare professionals, researchers, guideline methodologists, and people living with CKD; and the values and preferences of people with CKD when making treatment decisions, informed directly by patient partners on the guideline panel. The recommendations also take into account other factors such as practical issues, affordability, and health equity; follow standards for trustworthy guidelines; and use the GRADE approach.<a id="xref-ref-13-2" class="xref-bibr" href="#ref-13">13</a><a id="xref-ref-14-1" class="xref-bibr" href="#ref-14">14</a></p><div id="sec-10" class="subsection"><h3>Approach to risk stratification</h3><p id="p-23">Risks of death, adverse cardiovascular outcomes, and progression to kidney failure vary across GFRs and degrees of albuminuria. No single prognostic model was identified that accurately risk-stratifies individuals with varying CKD profiles and produces reliable estimates for all prioritised cardiovascular and kidney outcomes and harms. Ultimately, the panel agreed to use the CGA classification, which incorporates underlying cause of CKD (C), GFR (G), and degree of albuminuria (A), initially introduced in 2012 by KDIGO and maintained in its most recent practice guidance.<a id="xref-ref-1-2" class="xref-bibr" href="#ref-1">1</a><a id="xref-ref-10-2" class="xref-bibr" href="#ref-10">10</a><a id="xref-ref-11-3" class="xref-bibr" href="#ref-11">11</a> Data from a United Kingdom-based primary care database of records collected as part of routine care with general practitioners (99 129 patients) informed baseline risks and absolute effects across cardiovascular and kidney outcomes—specifically, all-cause and cardiovascular mortality, hospitalisation for heart failure, non-fatal myocardial infarction, non-fatal stroke, and kidney failure (see “How this guideline was created” below for more details). <a id="xref-ref-15-1" class="xref-bibr" href="#ref-15">15</a> Absolute effects were estimated over a five year time-frame.</p><p id="p-24"><a id="xref-table-wrap-1-1" class="xref-table" href="#T1">Table 1</a> summarises the four risk strata, adopting KDIGO’s classification system based on GFR and albuminuria categories; users may refer to reference materials from KDIGO for a visual representation of the risk stratification approach. </p><div id="T1" class="table pos-float"><div class="table"><div class="table-caption"><span class="table-label">Table 1</span> <p id="p-25" class="first-child">Chronic kidney disease (CKD) prognosis classification system used by KDIGO (adopted from the KDIGO 2024 clinical practice guideline for the evaluation and management of CKD<a id="xref-ref-11-4" class="xref-bibr" href="#ref-11">11</a>) </p><div class="sb-div caption-clear"></div></div><div class="table-inline"><div class="callout"><span>View this table:</span><ul class="callout-links"><li><a href="/highwire/markup/1101486/expansion?width=1000&height=500&iframe=true&postprocessors=highwire_figures%2Chighwire_math" class="colorbox colorbox-load table-expand-popup" rel="gallery-fragment-tables">View popup</a></li><li><a href="" class="table-expand-inline" data-table-url="/highwire/markup/1101486/expansion?postprocessors=highwire_figures%2Chighwire_math">View inline</a></li></ul></div></div></div><div></div></div><p id="p-27">Beyond accounting for GFR and degree of albuminuria, risk needs to be further stratified in order to tailor care to a given individual. To accomplish this, clinicians may choose to consider other comorbidities, and may use one of several available prognostic models (see appendix).</p></div><div id="sec-11" class="subsection"><h3>Applicability of recommendations</h3><p id="p-28">Recommendations apply to most adults with established CKD irrespective of type 2 diabetes status, heart failure status, sex, gender, or ethnicity. In line with internationally accepted definitions, CKD is defined as abnormalities in kidney structure or function for a minimum of three months, with health implications. Either decreased GFR (<60 mL/min per 1.73 m<sup>2</sup>) or one or more markers of kidney damage (such as albuminuria with an albumin to creatinine ratio ≥3 mg/mmol) must be present to establish the diagnosis. This guideline does not apply to adults meeting neither criterion and therefore not having CKD.</p><p id="p-29">Recommendations may not be applicable to certain other groups based on specific clinical considerations and lack of representation in included studies:</p><ul class="list-unord " id="list-2"><li id="list-item-4"><p id="p-30">Individuals receiving kidney replacement therapy</p></li><li id="list-item-5"><p id="p-31">Individuals who have received a kidney transplant</p></li><li id="list-item-6"><p id="p-32">Individuals with polycystic kidney disease</p></li><li id="list-item-7"><p id="p-33">Individuals with rare kidney diseases</p></li><li id="list-item-8"><p id="p-34">Individuals with estimated GFR <20 mL/min per 1.73 m<sup>2</sup> and not receiving kidney replacement therapy.</p></li></ul><p id="p-35">Age is not accounted for in the definition and classification system published by KDIGO in 2012 and maintained in its most recent practice guidelines. This may result in possible overestimation of risk in older adults (such as ≥65 years) and underestimation of risk in younger individuals (such as <40 years),<a id="xref-ref-16-1" class="xref-bibr" href="#ref-16">16</a> making recommendations less applicable to these groups.</p><p id="p-36">Moreover, individuals with rare kidney diseases (encompassing over 150 conditions as defined by KDIGO) can have higher rates of kidney failure but higher rates of survival relative to the general population of adults with CKD. Evidence regarding SGLT-2 inhibitors in such cases is either low certainty or non-existent. Recommendations may therefore be less applicable to these individuals.<a id="xref-ref-17-1" class="xref-bibr" href="#ref-17">17</a></p><div class="boxed-text" id="boxed-text-2"><h3>How this guideline was created</h3><div id="sec-12" class="subsection"><h4>Standards, methods, and processes for trustworthy guidance</h4><p id="p-37">This <em>BMJ Rapid Recommendation</em> was developed in accordance with standards for trustworthy guidance from the Institute of Medicine,<a id="xref-ref-13-3" class="xref-bibr" href="#ref-13">13</a> and strives to meet criteria for methodological rigour as per AGREE-II.<a id="xref-ref-21-1" class="xref-bibr" href="#ref-21">21</a></p></div><div id="sec-13" class="subsection"><h4>Who was involved?</h4><p id="p-38">We recruited an international guideline panel including patient partners (individuals living with CKD irrespective of disease stage and with or without a history of cardiovascular and kidney complications), general practitioners, internal medicine physicians, endocrinologists, nephrologists, and methodologists. Panel members were diverse in geography, sex, and expertise. The panel collectively determined the scope of this guideline and formulated recommendations. Methods and clinical co-chairs were selected by the MAGIC Evidence Ecosystem Foundation to lead panel deliberations.</p><p id="p-39">No panel member reported financial conflicts of interest. Intellectual conflicts of interest were minimised and managed in accordance with established policies for <em>The BMJ</em> and MAGIC.</p></div><div id="sec-14" class="subsection"><h4>What research did the guideline panel request and review?</h4><p id="p-40">The panel defined the clinical question and related population, intervention, outcomes and subgroups of interest to be addressed by the guideline. To fully address the specified question, an independent team of clinical epidemiologists, clinical experts, and biostatisticians conducted a pairwise systematic review to examine benefits and harms addressing the clinical question. Team members had expertise in GRADE methods.<a id="xref-ref-14-2" class="xref-bibr" href="#ref-14">14</a></p><p id="p-41">A second independent team of epidemiologists, clinical experts, and biostatisticians conducted a review of existing literature to identify prognostic models and classification systems to guide risk stratification of adults across different degrees of CKD severity. Identified prognostic models and classifications were reviewed by a core team of methodologists, and informed the strategy used for risk stratification in the guideline.</p><p id="p-42">The panel did not prioritise a separate systematic review on the values and preferences of adults with CKD and instead relied on input from patient partners and clinical experts on the panel to inform their judgments.</p></div><div id="sec-15" class="subsection"><h4>What outcomes did the guideline panel request and review?</h4><p id="p-43">Twelve patient-important outcomes were selected in the systematic review summarising benefits and harms of SGLT-2 inhibitor therapy. Panel members completed a survey to prioritise these outcomes from the perspective of an average adult with CKD.</p><p id="p-44">The following outcomes were deemed as being of critical importance (rated 7 to 9 on a 9-point ordinal scale): all-cause mortality, cardiovascular mortality, kidney failure, non-fatal stroke, hospitalisation for heart failure, non-fatal myocardial infarction, acute kidney injury requiring dialysis, and lower limb amputation.</p><p id="p-45">The following outcomes were deemed as being of importance (rated as 4 to 6 on the scale): ketoacidosis, bone fracture, genital infection, and symptomatic hypovolaemia.</p><p id="p-46">All 12 outcomes—six addressing benefit and six addressing harm (adverse events)—were retained as being patient-important.</p></div><div id="sec-16" class="subsection"><h4>How did the panel formulate recommendations?</h4><p id="p-47">Pre-established standards, methods, and processes for the <em>BMJ </em>Rapid Recommendations for developing trustworthy guidelines were adopted.<a id="xref-ref-19-2" class="xref-bibr" href="#ref-19">19</a><a id="xref-ref-20-2" class="xref-bibr" href="#ref-20">20</a> The GRADE approach provided the framework for evaluating certainty of available evidence and determining the strength and direction of recommendations. With GRADE, recommendations can be strong or weak, and for or against a treatment or course of action.<a id="xref-ref-14-3" class="xref-bibr" href="#ref-14">14</a></p><p id="p-48">To facilitate panel deliberations regarding interpretation of effects associated with SGLT-2 inhibitors, a survey was conducted asking panel members to rate the relative importance to patients of identified outcomes on an ordinal scale from 1 (not patient-important) to 9 (of critical importance). </p><p id="p-49">The panel adopted a consensus based approach to establish thresholds for minimal important differences for each prioritised outcome. The minimal important difference is the smallest treatment effect that a patient would deem as being important. Established thresholds facilitated interpretation of absolute effects (differentiating important from unimportant (that is, little or no difference) effects) and directly influenced ratings of precision when evaluating certainty of evidence using GRADE. Thresholds were generally inversely proportional to the relative patient importance of outcomes (that is, more patient-important outcomes were assigned lower thresholds whereby a treatment effect was deemed important). The minimal important difference thresholds used are summarised in the Summary of Findings tables provided in MAGICapp and in the linked systematic review and meta-analysis.</p><p id="p-50">Panel meetings were facilitated by methods and clinical co-chairs, and were conducted in July 2023 via web conference. The panel reviewed survey results regarding outcome prioritisation; reached agreement regarding an approach to risk stratification, patient values and preferences, and minimal important difference thresholds for interpreting treatment effects in absolute terms; and reviewed Summary of Findings tables, providing risk-stratified summaries of evidence across prioritised outcomes and their respective certainty ratings. A consensus based approach was adopted to move from evidence to recommendations, with informal voting used to anchor discussions and facilitate consensus. When the panel was unable to reach a consensus by discussion, a priori voting rules were established; voting was limited to panel members with clinical expertise and patient partners, excluding methodologists.</p><p id="p-51">In addition to consideration of absolute benefits and harms for prioritised patient-important outcomes and associated certainty of the evidence, several other factors were considered in moving from evidence to recommendations. Decisional domains included values and preferences of individuals living with CKD, feasibility, and acceptability. Issues related to equity were discussed but did not weigh heavily on deliberations when making recommendations. The panel also provided input regarding practicalities of administering SGLT-2 inhibitors, and issues related to applicability of recommendations to specific groups.</p><p id="p-52">Guidance was drafted by the methods chair with input from the clinical chair and methods trainee co-chair, and was circulated for review to the panel. Internal feedback was incorporated, and the panel approved the final version of the guidance prior to submission.</p></div><div id="sec-17" class="subsection"><h4>What is the approach to prognosis and risk prediction for outcomes?</h4><p id="p-53">The methods team conducted a review of existing prognostic models for risk stratification of individuals with CKD and establishing risk-stratified prognoses (that is, baseline risks) for cardiovascular and kidney outcomes. Evaluation of identified prognostic models, including those reported by the CKD Prognosis Consortium, yielded no models that provided accurate risk stratification (that is, adequate discrimination and calibration) across the majority of prioritised cardiovascular and kidney outcomes.</p><p id="p-54">The KDIGO classification was considered as an alternate approach to risk stratification of individuals with CKD based on a combined assessment of GFR (measured or estimated) and albuminuria levels.<a id="xref-ref-1-3" class="xref-bibr" href="#ref-1">1</a> This classification system was adopted due to its widespread use and practicality of application in clinical practice, requiring only GFR and albuminuria inputs to estimate risk. Data from a large retrospective cohort study including a primary care database—the United Kingdom Clinical Practice Research Datalink (CPRD)—was used to inform baseline risks and absolute effects across cardiovascular and kidney outcomes using this classification. The United Kingdom CPRD uses medical records collected as part of routine care with general practitioners, and was deemed appropriately representative of a community based population with CKD. Data were used to inform risk-stratified estimates for all-cause and cardiovascular mortality, hospitalisation for heart failure, non-fatal myocardial infarction, non-fatal stroke, and kidney failure.<a id="xref-ref-15-2" class="xref-bibr" href="#ref-15">15</a> Absolute effects were estimated over a five year time-frame for all outcomes.</p><p id="p-55">The methods team and panel acknowledged several limitations with adopting the KDIGO classification for risk stratification. The classification uses fixed thresholds for GFR and albuminuria without stratifying for age. Among younger individuals, a small GFR decline with or without albuminuria may represent pathological CKD with a higher risk of mortality and cardiovascular and kidney-related sequelae. On the contrary, among older individuals, an isolated decline in GFR may represent a physiological process without similar increases in these risks.<a id="xref-ref-16-2" class="xref-bibr" href="#ref-16">16</a> Therefore, universal thresholds for both variables could lead to a misleading incidence of CKD without proportionally increased or decreased risks of kidney failure and mortality, and with a risk of underestimating risk in younger individuals and overestimating it in older individuals.<a id="xref-ref-16-3" class="xref-bibr" href="#ref-16">16</a> The panel also noted issues related to GFR being either estimated or measured in the classification system and that different equations may be used to estimate GFR.</p><p id="p-56">The panel acknowledged that, although risk stratification was made possible for outcomes of benefit with this strategy, harm outcomes were not able to be similarly risk-stratified. Treatment effects were anticipated to be similar irrespective of baseline kidney function.<a id="xref-ref-22-1" class="xref-bibr" href="#ref-22">22</a> However, possible variation in baseline risks of harms across risk strata was anticipated (such as higher risk CKD groups are at higher risk of developing acute kidney injury). Certainty in evidence was therefore downgraded for indirectness in baseline risks to reflect the uncertainty in using the unstratified absolute effect estimates for these outcomes to inform decision making.</p></div><div id="sec-18" class="subsection"><h4>How were values and preferences of patients incorporated?</h4><p id="p-57">In the absence of a systematic review regarding the values and preferences of adults with CKD as they apply to SGLT-2 inhibitors, the panel relied on their own judgments of what well informed adults would value after carefully balancing benefits, harms, and burdens of therapy. Input from three patient partners who live with CKD informed judgments. The following values and preferences were deemed to be typical of well informed adults with CKD:</p><ul class="list-unord " id="list-3"><li id="list-item-9"><p id="p-58">Most adults living with CKD would be inclined to accept SGLT-2 inhibitor therapy when faced with moderate or high certainty of potential benefit and moderate or high certainty of little or no increased risk of harms. The larger the benefit, the more individuals would be willing to accept therapy.</p></li><li id="list-item-10"><p id="p-59">Most adults living with CKD would be disinclined to accept SGLT-2 inhibitor when faced with moderate or high certainty of little or no benefit regardless of associated harms.</p></li></ul><p id="p-60">Even when faced with moderate or high certainty of unimportant harms, there remains a possibility for harm that may drive individuals to avoid therapy unless benefits are compelling. Moreover, the introduction of an additional medication for individuals who may already be taking numerous medications (increased pill burden) may be considered an important harm. These considerations were incorporated when making recommendations.</p></div></div></div></div><div class="section other3" id="sec-19"><h2 class="">The recommendations</h2><p id="p-61">Recommendations across risk strata were informed by 13 randomised trials including 29 614 participants.</p><div id="sec-20" class="subsection"><h3>Recommendation 1: For adults at low risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour)</h3><p id="p-62"><em>Understanding the recommendation</em>—Moderate certainty of small but important reductions in risks of all-cause mortality and non-fatal stroke, balanced against moderate certainty of no important increase in the risk of harms, led to a weak recommendation in favour of treatment. The panel deliberated on whether treatment effects justified a weak recommendation in favour or against—given that benefits are more marginal than in higher risk groups and there remains a possibility of adverse events at the individual level (even in the absence of an important increase in risk per 1000 individuals)—and ultimately concluded that most patients would be inclined to accept treatment.</p><p id="p-63"><em>Benefits and harms</em>—In adults at low risk, SGLT-2 inhibitors probably decrease all-cause mortality (7 fewer per 1000 adults, 95% confidence interval 11 fewer to 1 fewer) and non-fatal stroke (10 fewer per 1000, 16 fewer to 2 fewer) (both moderate certainty) with little or no effect on cardiovascular mortality, hospitalisation for heart failure, kidney failure, and non-fatal myocardial infarction (all moderate to high certainty). Therapy is probably associated with little or no increased risk of harms, including acute kidney injury requiring dialysis (9 fewer per 1000, 14 fewer to 1 fewer), bone fracture (2 more per 1000, 10 fewer to 15 more), lower limb amputation (2 more per 1000, 4 fewer to 10 more), ketoacidosis (4 more per 1000, 1 more to 9 more), genital infection (27 more per 1000, 17 more to 39 more), and symptomatic hypovolaemia (32 more per 1000, 17 more to 49 more) (low certainty for lower limb amputation; moderate certainty for all other outcomes). Despite no effect estimates crossing the pre-established thresholds for minimal important differences across harm outcomes, the panel acknowledged adverse events remained plausible at the individual patient level.</p><p id="p-64"><em>Values and preferences</em>—Applying the values and preferences agreed on by the panel with patient partner input (see “How this guideline was created”), the majority of individuals would be expected to accept SGLT-2 inhibitors, though a reasonable proportion would likely decline, given the marginal benefits, increased pill burden, medication costs, and a residual possibility of harms.</p></div><div id="sec-21" class="subsection"><h3>Recommendation 2: For adults at moderate risk of CKD progression and complications, we suggest administering SGLT-2 inhibitors (weak recommendation in favour)</h3><p id="p-65"><em>Understanding the recommendation</em>—Moderate certainty of important reductions in risks of all-cause mortality and non-fatal stroke, balanced against moderate certainty of no important increase in the risk of harms, justified a weak recommendation in favour.</p><p id="p-66"><em>Benefits and harms</em>—In adults at moderate risk, SGLT-2 inhibitors probably decrease all-cause mortality (13 fewer per 1000, 95% CI 22 fewer to 2 fewer) and non-fatal stroke (13 fewer per 1000, 21 fewer to 3 fewer) (both moderate certainty), with little or no effect on cardiovascular mortality, non-fatal myocardial infarction (both moderate certainty), hospitalisation for heart failure, and kidney failure (both high certainty). Harms are the same as for adults in other risk strata, acknowledging uncertainty given lack of risk-stratified estimates and the residual possibility of adverse events at the individual patient level.</p><p id="p-67"><em>Values and preferences</em>—Same as for recommendation 1.</p></div><div id="sec-22" class="subsection"><h3>Recommendation 3: For adults at high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour)</h3><p id="p-68"><em>Understanding the recommendation</em>—Moderate certainty of important reductions in risks of mortality and most cardiovascular and kidney outcomes, combined with moderate certainty of no important increase in the risk of harms, motivated a strong recommendation in favour of treatment.</p><p id="p-69"><em>Benefits and harms</em>—In individuals at high risk, SGLT-2 inhibitors probably decrease all-cause mortality (24 fewer per 1000, 95% CI 41 fewer to 3 fewer) and cardiovascular mortality (6 fewer per 1000, 10 fewer to 1 fewer), non-fatal myocardial infarction (21 fewer per 1000, 34 fewer to 6 fewer), and non-fatal stroke (21 fewer per 1000, 34 fewer to 5 fewer) (all moderate certainty), with little or no effect on hospitalisation for heart failure and kidney failure (both high certainty). Harms are the same as for adults in other risk strata, acknowledging uncertainty given lack of risk-stratified estimates and the residual possibility of adverse events at the individual patient level.</p><p id="p-70"><em>Values and preferences</em>—Applying the values and preferences agreed on by the panel with patient partner input (see “How this guideline was created”), the panel inferred that all or almost all individuals would be inclined to receive SGLT-2 inhibitors in light of benefits substantially outweighing potential harms and treatment burdens, and did not anticipate substantial variability in preferences.</p></div><div id="sec-23" class="subsection"><h3>Recommendation 4: For adults at very high risk of CKD progression and complications, we recommend administering SGLT-2 inhibitors (strong recommendation in favour)</h3><p id="p-71"><em>Understanding the recommendation</em>—High certainty of an overall survival benefit and reduced risk of kidney failure, moderate certainty of important reductions in cardiovascular mortality and outcomes, and moderate certainty of no important increase in the risk of harms, justified a strong recommendation in favour.</p><p id="p-72"><em>Benefits and harms</em>—In individuals at very high risk, SGLT-2 inhibitors decrease all-cause mortality (48 fewer per 1000, 95% CI 84 fewer to 6 fewer) and kidney failure (58 fewer per 1000, 72 fewer to 42 fewer) (both high certainty), and probably decrease cardiovascular mortality (10 fewer per 1000, 17 fewer to 3 fewer), hospitalisation for heart failure (25 fewer per 1000, 32 fewer to 17 fewer), non-fatal myocardial infarction (32 fewer per 1000, 51 fewer to 9 fewer), and non-fatal stroke (25 fewer per 1000, 40 fewer to 6 fewer) (all moderate certainty). Harms are the same as for adults in other risk strata, acknowledging uncertainty given lack of risk-stratified estimates and the residual possibility of adverse events at the individual patient level.</p><p id="p-73"><em>Values and preferences</em>—Same as recommendation 3.</p><div class="boxed-text" id="boxed-text-3"><h3>Resource, equity, acceptability, and feasibility considerations</h3><p id="p-74">SGLT-2 inhibitors are widely available internationally.<a id="xref-ref-23-1" class="xref-bibr" href="#ref-23">23</a> Most SGLT-2 inhibitors are available as once-daily oral regimens. Individuals initiating SGLT-2 inhibitors require counselling regarding possibility of adverse events and sick day rules,<a id="xref-ref-24-1" class="xref-bibr" href="#ref-24">24</a><a id="xref-ref-25-1" class="xref-bibr" href="#ref-25">25</a> but otherwise do not require intensive follow-up. These considerations are applicable across risk strata.</p></div><div class="boxed-text" id="boxed-text-4"><h3>Practical considerations</h3><ul class="list-simple " id="list-4"><li id="list-item-11"><p id="p-75">The following should be considered when prescribing SGLT-2 inhibitors to adults with CKD:</p><ul class="list-unord " id="list-5"><li id="list-item-12"><p id="p-76">SGLT-2 inhibitors may be initiated at the highest possible dose and do not require dose titration</p></li><li id="list-item-13"><p id="p-77">SGLT-2 inhibitors may be initiated in adults with estimated glomerular filtration rate (GFR) ≥20 mL/min per 1.73 m<sup>2</sup></p></li><li id="list-item-14"><p id="p-78">Once initiated, SGLT-2 inhibitors may be continued even if estimated GFR <20 mL/min per 1.73 m<sup>2</sup> until dialysis initiation</p></li><li id="list-item-15"><p id="p-79">SGLT-2 inhibitors are likely to cause an acute transient decline in GFR within two to four weeks after initiation. However, it is not routinely necessary to check blood tests after initiating an SGLT-2 inhibitor in adults with CKD, except in high risk individuals such as those with prior acute kidney injury or at risk of volume depletion</p></li><li id="list-item-16"><p id="p-80">A transient decline in GFR should not be a reason to discontinue therapy unless it exceeds 25% from baseline. If treatment is discontinued, another attempt to initiate therapy may be pursued after recovery of kidney function</p></li><li id="list-item-17"><p id="p-81">Individuals who are taking diuretics at baseline or are otherwise at risk of volume depletion may require closer monitoring and diuretic titration when initiating SGLT-2 inhibitors. This may be particularly pertinent with exposure to hot weather</p></li><li id="list-item-18"><p id="p-82">In individuals with concomitant heart failure, SGLT-2 inhibitors should be initiated irrespective of kidney function and degree of albuminuria</p></li></ul></li><li id="list-item-19"><p id="p-83">Individuals should be counselled regarding the following:</p><ul class="list-unord " id="list-6"><li id="list-item-20"><p id="p-84">Potential adverse events, including genital mycotic infections, acute kidney injury, fractures, euglycaemic ketoacidosis, volume depletion, Fournier's gangrene, and amputations. Even for harm outcomes where important increases in risk are not evident, a residual risk of such events exists and warrants counselling</p></li><li id="list-item-21"><p id="p-85">The need to stop medication if unwell, engaging in prolonged fasting, undergoing surgery, or experiencing severe gastrointestinal losses such as diarrhoea or vomiting (that is, sick day counselling).</p></li></ul></li></ul><p id="p-86">The beneficial effects of SGLT-2 inhibitors are considered to be class effects. By extension, all SGLT-2 inhibitors are considered similarly. SGLT-2 inhibitors that may be considered for use in individuals with CKD include canagliflozin, dapagliflozin, and empagliflozin.</p></div></div></div><div class="section other4" id="sec-24"><h2 class="">Key uncertainties and future directions</h2><p id="p-87">We identified the following key uncertainties and areas for future research:</p><ul class="list-unord " id="list-7"><li id="list-item-22"><p id="p-88">Development of a prognostic model that estimates cardiovascular and kidney risk in adults with CKD (currently available models either do not provide accurate risk stratification or do not do so for the majority of key outcomes)</p></li><li id="list-item-23"><p id="p-89">Risk estimation for patient-important outcomes that incorporates age stratification (not currently incorporated into the KDIGO classification based on GFR and albuminuria)</p></li><li id="list-item-24"><p id="p-90">Risk-stratified estimates for patient-important harm outcomes (no robust evidence currently available to inform baseline risks across different risk strata)</p></li><li id="list-item-25"><p id="p-91">Safety of initiating SGLT-2 inhibitors with a baseline GFR <20 mL/min per 1.73 m<sup>2</sup> (current evidence and guidance are less applicable to this group)</p></li><li id="list-item-26"><p id="p-92">Impact of initiating SGLT-2 inhibitors among adults receiving kidney replacement therapy (peritoneal or haemodialysis) or after kidney transplantation (current evidence and guidance are less applicable to these groups)</p></li><li id="list-item-27"><p id="p-93">Impact of continuing SGLT-2 inhibitors with low GFRs (particularly <20 mL/min per 1.73 m<sup>2</sup>) or for adults who begin kidney replacement therapy (current evidence and guidance are more uncertain for or less applicable to these groups)</p></li><li id="list-item-28"><p id="p-94">Impact of initiating SGLT-2 inhibitors for adults with rare kidney diseases, particularly autosomal dominant polycystic kidney disease (current evidence and guidance are less applicable to these groups)</p></li><li id="list-item-29"><p id="p-95">Impact of initiating SGLT-2 inhibitors for adults with other diseases in which kidney disease is often implicated, such as antineutrophil cytoplasmic antibody (ANCA) associated vasculitis and lupus nephritis (current evidence and guidance are less applicable to these groups)<a id="xref-ref-18-1" class="xref-bibr" href="#ref-18">18</a></p></li><li id="list-item-30"><p id="p-96">Evidence of values and preferences of adults with CKD regarding use of SGLT-2 inhibitors as it applies to different risk strata (more robust evidence incorporating input from a larger cohort of adults living with CKD is warranted).</p></li></ul><div class="boxed-text" id="boxed-text-5"><h3>How patients were involved in the creation of this article</h3><p id="p-97">The panel included three patients with CKD. Their perspectives informed judgments regarding values and preferences associated with decision-making related to SGLT-2 inhibitors.</p></div></div><div class="section ack" id="ack-1"><h2>Acknowledgments</h2><p id="p-98">We thank all the following panel members who contributed to this endeavour:</p><p id="p-99">• Patient partners: Frederic Coyac, Andrew Demaine, Edward Machuve.</p><p id="p-100">• Clinical experts: Bert Aertgeerts, Pauline Darbellay Farhoumand, Anja Fog Heen, Vivekanand Jha, Evi Nagler, Belen Ponte (clinical co-chair).</p><p id="p-101">• Methodologists: Arnav Agarwal (methods co-chair), Thomas Agoritsas (MAGIC lead and primary supervisor), Farid Foroutan, Gordon Guyatt, Sheyu Li, Daniel Rayner, David Tunnicliffe, Per Olav Vandvik, Xiaoxi Zeng (methods co-chair trainee).</p></div><div class="section fn-group" id="fn-group-1"><h2>Footnotes</h2><ul><li class="fn-financial-disclosure" id="fn-2"><p id="p-102">Funding: This guideline was funded by the West China Hospital, Sichuan University (ZYJC18010 and ZYYC24001). The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. MAGIC provided oversight and methodological contributions and support throughout the guideline process.</p></li><li class="fn-conflict" id="fn-3"><p id="p-103">Competing interests: All authors have completed the <em>BMJ</em> Rapid Recommendations disclosure of interests form. <em>The BMJ</em> has judged that there are no disqualifying financial ties to commercial companies. The authors declare the following other interests: none.</p></li><li class="fn-other" id="fn-4"><p id="p-104">Provenance and peer review: This publication was commissioned by <em>The BMJ</em> in partnership with the MAGIC Evidence Ecosystem Foundation, in the context of the <em>BMJ</em> Rapid Recommendations. Pre-publication internal and external peer review was managed by MAGIC, and internal review was managed by <em>The BMJ</em>. 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class="nlm-given-names">Arnav</span> <span class="nlm-surname">Agarwal</span> <span class="nlm-role">internist, methods co-chair</span></span>, <span data-delta="1"><span class="nlm-given-names">Xiaoxi</span> <span class="nlm-surname">Zeng</span> <span class="nlm-role">nephrologist, methods co-chair trainee</span></span>, <span data-delta="2"><span class="nlm-given-names">Sheyu</span> <span class="nlm-surname">Li</span> <span class="nlm-role">endocrinologist, methodologist</span></span>, <span data-delta="3"><span class="nlm-given-names">Daniel</span> <span class="nlm-surname">Rayner</span> <span class="nlm-role">methodologist</span></span>, <span data-delta="4"><span class="nlm-given-names">Farid</span> <span class="nlm-surname">Foroutan</span> <span class="nlm-role">methodologist</span></span>, <span data-delta="5"><span class="nlm-given-names">Bert</span> <span class="nlm-surname">Aertgeerts</span> <span class="nlm-role">primary care physician</span></span> et al</div> <div 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