Application of Analytical Chemistry and Bioanalytical Chemis

<!DOCTYPE html> <html lang="fr"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <title>Application of Analytical Chemistry and Bioanalytical Chemis | 109419</title> <meta name="keywords" content="Gary F Massart, "/> <meta name="description" content="Bile Acids (BAs) constitute an important class of biological molecules produced in the metabolism of all vertebrates. In mammals, they exhibit the so calle..109419"/> <meta name="citation_publisher" content="Premiers savants" /> <meta name="citation_journal_title" content="Aperçus de l'électrochimie analytique"> <meta name="citation_title" content="Application of Analytical Chemistry and Bioanalytical Chemistry"> <meta name="citation_author" content="Gary F Massart" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="7"> <meta name="citation_issue" content="5"> <meta name="citation_abstract" content="Bile Acids (BAs) constitute an important class of biological molecules produced in the metabolism of all vertebrates. In mammals, they exhibit the so called C24 structure: 24 carbon atoms form a steroid nucleus (three six-member rings indicated as A, B C and a five-member ring indicated as D) and a fivecarbon side chain with a carboxyl group at the C-24 position. The A and B rings are linked in cis configuration, inducing an overall bent shape. Such a structural feature delineates a concave and convex side of the steroidal backbone where OH groups in α orientation (up to three) and two methyl groups in β orientation, respectively, point out. Therefore, two opposite faces with hydrophilic and hydrophobic properties can be distinguished. Further variations of the molecular structure can be observed at C-3 carbon due to hydroxyl, sulfate or glucuronate substituents. C-6 and C-24 glucoronide conjugates were also found in humans. Other C-24 substituents are glycine or taurine. 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In mammals, they exhibit the so called C24 structure: 24 carbon atoms form a steroid nucleus (three six-member rings indicated as A, B C and a five-member ring indicated as D) and a fivecarbon side chain with a carboxyl group at the C-24 position. The A and B rings are linked in cis configuration, inducing an overall bent shape. Such a structural feature delineates a concave and convex side of the steroidal backbone where OH groups in α orientation (up to three) and two methyl groups in β orientation, respectively, point out. Therefore, two opposite faces with hydrophilic and hydrophobic properties can be distinguished. Further variations of the molecular structure can be observed at C-3 carbon due to hydroxyl, sulfate or glucuronate substituents. C-6 and C-24 glucoronide conjugates were also found in humans. Other C-24 substituents are glycine or taurine.</p> </p> <div class="alert alert-info text-left"><b>Avertissement:</b> test</div> <div class="nav social-icons align-items-center"> <p class="m-0">Partagez cet article:</p> <a class="facebook" title="Cliquez ici" target="_blank" href="https://www.facebook.com/sharer.php?u=https://french.primescholars.com/abstract/application-of-analytical-chemistry-and-bioanalytical-chemistry-109419.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="twitter" title="Cliquez ici" target="_blank" href="https://twitter.com/share?url=https://french.primescholars.com/abstract/application-of-analytical-chemistry-and-bioanalytical-chemistry-109419.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="linkedin" title="Cliquez ici" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://french.primescholars.com/abstract/application-of-analytical-chemistry-and-bioanalytical-chemistry-109419.html" 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Application of Analytical Chemistry and Bioanalytical Chemis | 109419