CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available" lang="zh" dir="ltr"> <head> <meta charset="UTF-8"> <title>替格瑞洛 - 维基百科，自由的百科全书</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )zhwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":["",""],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"zh", "wgMonthNames":["","1月","2月","3月","4月","5月","6月","7月","8月","9月","10月","11月","12月"],"wgRequestId":"0741cb18-0055-4fa0-9853-109f8b623e14","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"替格瑞洛","wgTitle":"替格瑞洛","wgCurRevisionId":83904359,"wgRevisionId":83904359,"wgArticleId":3223859,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["使用PMID魔术链接的页面","包含医学声明的条目","带有非标准子页面的Template:drugs.com链接","無CAS號重定向的物質條目","含有未校對CAS號的條目","具有ChemSpider參數的藥物條目","從維基數據獲取的ECHA InfoCard編碼","Infobox-drug molecular-weight unexpected-character","包含Infobox drug模板条目没有结构图","没有DrugBank识别码的化学条目","没有InChI来源的条目","没有疫苗目标的包含Infobox drug模板的条目", "孤立的子导航框","使用醫學導航子模板的文章","抗血小板药","CYP3A4抑制剂","氟苯","醇","环丙基化合物","正丙基化合物"],"wgPageViewLanguage":"zh","wgPageContentLanguage":"zh","wgPageContentModel":"wikitext","wgRelevantPageName":"替格瑞洛","wgRelevantArticleId":3223859,"wgUserVariant":"zh","wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":true,"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"zh","pageLanguageDir":"ltr","pageVariantFallbacks":["zh-hans","zh-hant","zh-cn","zh-tw","zh-hk","zh-sg","zh-mo","zh-my"]},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":true,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":20000,"wgRelatedArticlesCompat":[],"wgCentralAuthMobileDomain":false, "wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q420542","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false,"wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false};RLSTATE={"ext.gadget.large-font":"ready","ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage" :"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"};RLPAGEMODULES=["ext.cite.ux-enhancements","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.edit0","ext.gadget.WikiMiniAtlas","ext.gadget.UnihanTooltips","ext.gadget.Difflink","ext.gadget.pseudonamespace-UI","ext.gadget.SpecialWikitext","ext.gadget.switcher","ext.gadget.VariantAlly","ext.gadget.AdvancedSiteNotices","ext.gadget.hideConversionTab","ext.gadget.internalLinkHelper-altcolor","ext.gadget.noteTA","ext.gadget.NavFrame","ext.gadget.collapsibleTables","ext.gadget.scrollUpButton","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups","ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions", "wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession","wikibase.sidebar.tracking"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=zh&modules=ext.cite.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=zh&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=zh&modules=ext.gadget.large-font&only=styles&skin=vector-2022"> <link rel="stylesheet" href="/w/load.php?lang=zh&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.4"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/0/0f/Ticagrelor.svg/1200px-Ticagrelor.svg.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="737"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/0/0f/Ticagrelor.svg/800px-Ticagrelor.svg.png"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="492"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/0/0f/Ticagrelor.svg/640px-Ticagrelor.svg.png"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="393"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="替格瑞洛 - 维基百科，自由的百科全书"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//zh.m.wikipedia.org/wiki/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" type="application/x-wiki" title="编辑本页" href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (zh)"> <link rel="EditURI" type="application/rsd+xml" href="//zh.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://zh.wikipedia.org/wiki/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh" href="https://zh.wikipedia.org/wiki/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh-Hans" href="https://zh.wikipedia.org/zh-hans/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh-Hans-CN" href="https://zh.wikipedia.org/zh-cn/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh-Hans-MY" href="https://zh.wikipedia.org/zh-my/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh-Hans-SG" href="https://zh.wikipedia.org/zh-sg/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh-Hant" href="https://zh.wikipedia.org/zh-hant/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh-Hant-HK" href="https://zh.wikipedia.org/zh-hk/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh-Hant-MO" href="https://zh.wikipedia.org/zh-mo/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="zh-Hant-TW" href="https://zh.wikipedia.org/zh-tw/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="alternate" hreflang="x-default" href="https://zh.wikipedia.org/wiki/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.zh"> <link rel="alternate" type="application/atom+xml" title="Wikipedia的Atom feed" href="/w/index.php?title=Special:%E6%9C%80%E8%BF%91%E6%9B%B4%E6%94%B9&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="//login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-替格瑞洛 rootpage-替格瑞洛 skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">跳转到内容</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="站点"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="主菜单" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">主菜单</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">主菜单</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">移至侧栏</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">隐藏</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> 导航 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Wikipedia:%E9%A6%96%E9%A1%B5" title="访问首页[z]" accesskey="z"><span>首页</span></a></li><li id="n-indexpage" class="mw-list-item"><a href="/wiki/Wikipedia:%E5%88%86%E7%B1%BB%E7%B4%A2%E5%BC%95" title="以分类索引搜寻中文维基百科"><span>分类索引</span></a></li><li id="n-Featured_content" class="mw-list-item"><a href="/wiki/Portal:%E7%89%B9%E8%89%B2%E5%85%A7%E5%AE%B9" title="查看中文维基百科的特色内容"><span>特色内容</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:%E6%96%B0%E8%81%9E%E5%8B%95%E6%85%8B" title="提供当前新闻事件的背景资料"><span>新闻动态</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Special:%E6%9C%80%E8%BF%91%E6%9B%B4%E6%94%B9" title="列出维基百科中的最近修改[r]" accesskey="r"><span>最近更改</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Special:%E9%9A%8F%E6%9C%BA%E9%A1%B5%E9%9D%A2" title="随机载入一个页面[x]" accesskey="x"><span>随机条目</span></a></li> </ul> </div> </div> <div id="p-help" class="vector-menu mw-portlet mw-portlet-help" > <div class="vector-menu-heading"> 帮助 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Help:%E7%9B%AE%E5%BD%95" title="寻求帮助"><span>帮助</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:%E7%A4%BE%E7%BE%A4%E9%A6%96%E9%A1%B5" title="关于本计划、你可以做什么、应该如何做"><span>维基社群</span></a></li><li id="n-policy" class="mw-list-item"><a href="/wiki/Wikipedia:%E6%96%B9%E9%87%9D%E8%88%87%E6%8C%87%E5%BC%95" title="查看维基百科的方针和指引"><span>方针与指引</span></a></li><li id="n-villagepump" class="mw-list-item"><a href="/wiki/Wikipedia:%E4%BA%92%E5%8A%A9%E5%AE%A2%E6%A0%88" title="参与维基百科社群的讨论"><span>互助客栈</span></a></li><li id="n-Information_desk" class="mw-list-item"><a href="/wiki/Wikipedia:%E7%9F%A5%E8%AF%86%E9%97%AE%E7%AD%94" title="解答任何与维基百科无关的问题的地方"><span>知识问答</span></a></li><li id="n-conversion" class="mw-list-item"><a href="/wiki/Wikipedia:%E5%AD%97%E8%AF%8D%E8%BD%AC%E6%8D%A2" title="提出字词转换请求"><span>字词转换</span></a></li><li id="n-IRC" class="mw-list-item"><a href="/wiki/Wikipedia:IRC%E8%81%8A%E5%A4%A9%E9%A2%91%E9%81%93"><span>IRC即时聊天</span></a></li><li id="n-contact" class="mw-list-item"><a href="/wiki/Wikipedia:%E8%81%94%E7%BB%9C%E6%88%91%E4%BB%AC" title="如何联络维基百科"><span>联络我们</span></a></li><li id="n-about" class="mw-list-item"><a href="/wiki/Wikipedia:%E5%85%B3%E4%BA%8E" title="查看维基百科的简介"><span>关于维基百科</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Wikipedia:%E9%A6%96%E9%A1%B5" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="维基百科" src="/static/images/mobile/copyright/wikipedia-wordmark-zh.svg" style="width: 6.5625em; height: 1.375em;"> <img class="mw-logo-tagline" alt="自由的百科全书" src="/static/images/mobile/copyright/wikipedia-tagline-zh.svg" width="103" height="14" style="width: 6.4375em; height: 0.875em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Special:%E6%90%9C%E7%B4%A2" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="搜索维基百科[f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>搜索</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="搜索维基百科" aria-label="搜索维基百科" autocapitalize="sentences" title="搜索维基百科[f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Special:搜索"> </div> <button class="cdx-button cdx-search-input__end-button">搜索</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="个人工具"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="外观"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="更改页面字体大小、宽度和颜色的外观" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="外观" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">外观</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/?utm_source=donate&utm_medium=sidebar&utm_campaign=spontaneous&uselang=zh-hans" class=""><span>资助维基百科</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:%E5%88%9B%E5%BB%BA%E8%B4%A6%E6%88%B7&returnto=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" title="我们推荐您创建账号并登录，但这不是强制性的" class=""><span>创建账号</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:%E7%94%A8%E6%88%B7%E7%99%BB%E5%BD%95&returnto=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" title="建议你登录，尽管并非必须。[o]" accesskey="o" class=""><span>登录</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="更多选项" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="个人工具" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">个人工具</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="用户菜单" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/?utm_source=donate&utm_medium=sidebar&utm_campaign=spontaneous&uselang=zh-hans"><span>资助维基百科</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:%E5%88%9B%E5%BB%BA%E8%B4%A6%E6%88%B7&returnto=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" title="我们推荐您创建账号并登录，但这不是强制性的"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>创建账号</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:%E7%94%A8%E6%88%B7%E7%99%BB%E5%BD%95&returnto=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" title="建议你登录，尽管并非必须。[o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>登录</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> 未登录编辑者的页面 <a href="/wiki/Help:%E6%96%B0%E6%89%8B%E5%85%A5%E9%97%A8" aria-label="了解有关编辑的更多信息"><span>了解详情</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:%E6%88%91%E7%9A%84%E8%B4%A1%E7%8C%AE" title="来自此IP地址的编辑列表[y]" accesskey="y"><span>贡献</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:%E6%88%91%E7%9A%84%E8%AE%A8%E8%AE%BA%E9%A1%B5" title="对于来自此IP地址编辑的讨论[n]" accesskey="n"><span>讨论</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="站点"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="目录" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">目录</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">移至侧栏</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">隐藏</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">序言</div> </a> </li> <li id="toc-简介" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#简介"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>简介</span> </div> </a> <ul id="toc-简介-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-药理毒理" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#药理毒理"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>药理毒理</span> </div> </a> <button aria-controls="toc-药理毒理-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>开关药理毒理子章节</span> </button> <ul id="toc-药理毒理-sublist" class="vector-toc-list"> <li id="toc-药效学特性" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#药效学特性"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>药效学特性</span> </div> </a> <ul id="toc-药效学特性-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-临床试验" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#临床试验"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>临床试验</span> </div> </a> <ul id="toc-临床试验-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-毒理学数据" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#毒理学数据"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>毒理学数据</span> </div> </a> <ul id="toc-毒理学数据-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-药代动力学特性" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#药代动力学特性"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>药代动力学特性</span> </div> </a> <ul id="toc-药代动力学特性-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-适应症" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#适应症"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>适应症</span> </div> </a> <ul id="toc-适应症-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-用法用量" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#用法用量"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>用法用量</span> </div> </a> <ul id="toc-用法用量-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-不良反应" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#不良反应"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>不良反应</span> </div> </a> <ul id="toc-不良反应-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-禁忌症" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#禁忌症"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>禁忌症</span> </div> </a> <ul id="toc-禁忌症-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-注意事项" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#注意事项"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>注意事项</span> </div> </a> <ul id="toc-注意事项-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-参考资料" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#参考资料"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>参考资料</span> </div> </a> <ul id="toc-参考资料-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="目录" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="开关目录" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">开关目录</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">替格瑞洛</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="前往另一种语言写成的文章。19种语言可用" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-19" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">19种语言</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AA%D9%8A%D9%83%D8%A7%D8%BA%D8%B1%D9%8A%D9%84%D9%88%D8%B1" title="تيكاغريلور – 阿拉伯语" lang="ar" hreflang="ar" data-title="تيكاغريلور" data-language-autonym="العربية" data-language-local-name="阿拉伯语" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Ticagrelor" title="Ticagrelor – 德语" lang="de" hreflang="de" data-title="Ticagrelor" data-language-autonym="Deutsch" data-language-local-name="德语" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Ticagrelor" title="Ticagrelor – 英语" lang="en" hreflang="en" data-title="Ticagrelor" data-language-autonym="English" data-language-local-name="英语" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Ticagrelor" title="Ticagrelor – 西班牙语" lang="es" hreflang="es" data-title="Ticagrelor" data-language-autonym="Español" data-language-local-name="西班牙语" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AA%DB%8C%DA%A9%D8%A7%DA%AF%D8%B1%D9%84%D9%88%D8%B1" title="تیکاگرلور – 波斯语" lang="fa" hreflang="fa" data-title="تیکاگرلور" data-language-autonym="فارسی" data-language-local-name="波斯语" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Ticagrelor" title="Ticagrelor – 法语" lang="fr" hreflang="fr" data-title="Ticagrelor" data-language-autonym="Français" data-language-local-name="法语" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%98%D7%99%D7%A7%D7%92%D7%A8%D7%9C%D7%95%D7%A8" title="טיקגרלור – 希伯来语" lang="he" hreflang="he" data-title="טיקגרלור" data-language-autonym="עברית" data-language-local-name="希伯来语" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Tikagrelor" title="Tikagrelor – 印度尼西亚语" lang="id" hreflang="id" data-title="Tikagrelor" data-language-autonym="Bahasa Indonesia" data-language-local-name="印度尼西亚语" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Ticagrelor" title="Ticagrelor – 意大利语" lang="it" hreflang="it" data-title="Ticagrelor" data-language-autonym="Italiano" data-language-local-name="意大利语" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AB%E3%82%B0%E3%83%AC%E3%83%AD%E3%83%AB" title="チカグレロル – 日语" lang="ja" hreflang="ja" data-title="チカグレロル" data-language-autonym="日本語" data-language-local-name="日语" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A2%D0%B8%D0%BA%D0%B0%D0%B3%D1%80%D0%B5%D0%BB%D0%BE%D1%80" title="Тикагрелор – 马其顿语" lang="mk" hreflang="mk" data-title="Тикагрелор" data-language-autonym="Македонски" data-language-local-name="马其顿语" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Ticagrelor" title="Ticagrelor – 荷兰语" lang="nl" hreflang="nl" data-title="Ticagrelor" data-language-autonym="Nederlands" data-language-local-name="荷兰语" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%9F%E0%AC%BF%E0%AC%95%E0%AC%BE%E0%AC%97%E0%AD%8D%E0%AC%B0%E0%AD%87%E0%AC%B2%E0%AD%8B%E0%AC%B0" title="ଟିକାଗ୍ରେଲୋର – 奥里亚语" lang="or" hreflang="or" data-title="ଟିକାଗ୍ରେଲୋର" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="奥里亚语" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Ticagrelor" title="Ticagrelor – 葡萄牙语" lang="pt" hreflang="pt" data-title="Ticagrelor" data-language-autonym="Português" data-language-local-name="葡萄牙语" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Ticagrelor" title="Ticagrelor – 罗马尼亚语" lang="ro" hreflang="ro" data-title="Ticagrelor" data-language-autonym="Română" data-language-local-name="罗马尼亚语" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Tikagrelor" title="Tikagrelor – 塞尔维亚-克罗地亚语" lang="sh" hreflang="sh" data-title="Tikagrelor" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="塞尔维亚-克罗地亚语" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Tikagrelor" title="Tikagrelor – 塞尔维亚语" lang="sr" hreflang="sr" data-title="Tikagrelor" data-language-autonym="Српски / srpski" data-language-local-name="塞尔维亚语" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%9F%E0%B0%BF%E0%B0%95%E0%B0%BE%E0%B0%97%E0%B1%8D%E0%B0%B0%E0%B1%86%E0%B0%B2%E0%B0%B0%E0%B1%8D" title="టికాగ్రెలర్ – 泰卢固语" lang="te" hreflang="te" data-title="టికాగ్రెలర్" data-language-autonym="తెలుగు" data-language-local-name="泰卢固语" class="interlanguage-link-target"><span>తెలుగు</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A2%D1%96%D0%BA%D0%B0%D0%B3%D1%80%D0%B5%D0%BB%D0%BE%D1%80" title="Тікагрелор – 乌克兰语" lang="uk" hreflang="uk" data-title="Тікагрелор" data-language-autonym="Українська" data-language-local-name="乌克兰语" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q420542#sitelinks-wikipedia" title="编辑跨语言链接" class="wbc-editpage">编辑链接</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="命名空间"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" title="浏览条目正文[c]" accesskey="c"><span>条目</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" rel="discussion" title="关于此页面的讨论[t]" accesskey="t"><span>讨论</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown " > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="更改语言变体" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">不转换</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-varlang-0" class="selected ca-variants-zh mw-list-item"><a href="/zh/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh" hreflang="zh"><span>不转换</span></a></li><li id="ca-varlang-1" class="ca-variants-zh-Hans mw-list-item"><a href="/zh-hans/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh-Hans" hreflang="zh-Hans"><span>简体</span></a></li><li id="ca-varlang-2" class="ca-variants-zh-Hant mw-list-item"><a href="/zh-hant/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh-Hant" hreflang="zh-Hant"><span>繁體</span></a></li><li id="ca-varlang-3" class="ca-variants-zh-Hans-CN mw-list-item"><a href="/zh-cn/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh-Hans-CN" hreflang="zh-Hans-CN"><span>大陆简体</span></a></li><li id="ca-varlang-4" class="ca-variants-zh-Hant-HK mw-list-item"><a href="/zh-hk/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh-Hant-HK" hreflang="zh-Hant-HK"><span>香港繁體</span></a></li><li id="ca-varlang-5" class="ca-variants-zh-Hant-MO mw-list-item"><a href="/zh-mo/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh-Hant-MO" hreflang="zh-Hant-MO"><span>澳門繁體</span></a></li><li id="ca-varlang-6" class="ca-variants-zh-Hans-MY mw-list-item"><a href="/zh-my/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh-Hans-MY" hreflang="zh-Hans-MY"><span>大马简体</span></a></li><li id="ca-varlang-7" class="ca-variants-zh-Hans-SG mw-list-item"><a href="/zh-sg/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh-Hans-SG" hreflang="zh-Hans-SG"><span>新加坡简体</span></a></li><li id="ca-varlang-8" class="ca-variants-zh-Hant-TW mw-list-item"><a href="/zh-tw/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" lang="zh-Hant-TW" hreflang="zh-Hant-TW"><span>臺灣正體</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="查看"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"><span>阅读</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit" title="编辑该页面[e]" accesskey="e"><span>编辑</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=history" title="本页面的早前版本。[h]" accesskey="h"><span>查看历史</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="页面工具"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="工具" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">工具</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">工具</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">移至侧栏</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">隐藏</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="更多选项" > <div class="vector-menu-heading"> 操作 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B"><span>阅读</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit" title="编辑该页面[e]" accesskey="e"><span>编辑</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=history"><span>查看历史</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> 常规 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:%E9%93%BE%E5%85%A5%E9%A1%B5%E9%9D%A2/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" title="列出所有与本页相链的页面[j]" accesskey="j"><span>链入页面</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:%E9%93%BE%E5%87%BA%E6%9B%B4%E6%94%B9/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B" rel="nofollow" title="页面链出所有页面的更改[k]" accesskey="k"><span>相关更改</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Project:%E4%B8%8A%E4%BC%A0" title="上传图像或多媒体文件[u]" accesskey="u"><span>上传文件</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Special:%E7%89%B9%E6%AE%8A%E9%A1%B5%E9%9D%A2" title="全部特殊页面的列表[q]" accesskey="q"><span>特殊页面</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&oldid=83904359" title="此页面该修订版本的固定链接"><span>固定链接</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=info" title="关于此页面的更多信息"><span>页面信息</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:%E5%BC%95%E7%94%A8%E6%AD%A4%E9%A1%B5%E9%9D%A2&page=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&id=83904359&wpFormIdentifier=titleform" title="有关如何引用此页面的信息"><span>引用此页</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:URL%E7%BC%A9%E7%9F%AD%E7%A8%8B%E5%BA%8F&url=https%3A%2F%2Fzh.wikipedia.org%2Fwiki%2F%25E6%259B%25BF%25E6%25A0%25BC%25E7%2591%259E%25E6%25B4%259B"><span>获取短链接</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fzh.wikipedia.org%2Fwiki%2F%25E6%259B%25BF%25E6%25A0%25BC%25E7%2591%259E%25E6%25B4%259B"><span>下载二维码</span></a></li> </ul> </div> </div> <div id="p-electronpdfservice-sidebar-portlet-heading" class="vector-menu mw-portlet mw-portlet-electronpdfservice-sidebar-portlet-heading" > <div class="vector-menu-heading"> 打印/导出 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="electron-print_pdf" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=show-download-screen"><span>下载为PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="javascript:print();" rel="alternate" title="本页面的可打印版本[p]" accesskey="p"><span>打印页面</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> 在其他项目中 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Ticagrelor" hreflang="en"><span>维基共享资源</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q420542" title="链接到连接的数据仓库项目[g]" accesskey="g"><span>维基数据项目</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="页面工具"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="外观"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">外观</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">移至侧栏</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">隐藏</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">维基百科，自由的百科全书</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="zh" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r84833064">.mw-parser-output .hatnote{font-size:small}.mw-parser-output div.hatnote{padding-left:2em;margin-bottom:0.8em;margin-top:0.8em}.mw-parser-output .hatnote-notice-img::after{content:"\202f \202f \202f \202f "}.mw-parser-output .hatnote-notice-img-small::after{content:"\202f \202f "}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}body.skin-minerva .mw-parser-output .hatnote-notice-img,body.skin-minerva .mw-parser-output .hatnote-notice-img-small{display:none}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable selfref"><span typeof="mw:File"><a href="/wiki/File:Star_of_life_caution.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/20px-Star_of_life_caution.svg.png" decoding="async" width="20" height="18" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/30px-Star_of_life_caution.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/40px-Star_of_life_caution.svg.png 2x" data-file-width="210" data-file-height="190" /></a></span> <a href="/wiki/%E7%BB%B4%E5%9F%BA%E7%99%BE%E7%A7%91" title="维基百科">维基百科</a>中的醫學内容<b>仅供参考</b>，並<b>不能</b>視作專業意見。如需獲取醫療幫助或意見，请咨询专业人士。詳見<b><a href="/wiki/Wikipedia:%E5%8C%BB%E5%AD%A6%E5%A3%B0%E6%98%8E" title="Wikipedia:医学声明">醫學聲明</a></b>。</div> <style data-mw-deduplicate="TemplateStyles:r83732082">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}body.skin-minerva .mw-parser-output .infobox-header,body.skin-minerva .mw-parser-output .infobox-subheader,body.skin-minerva .mw-parser-output .infobox-above,body.skin-minerva .mw-parser-output .infobox-title,body.skin-minerva .mw-parser-output .infobox-image,body.skin-minerva .mw-parser-output .infobox-full-data,body.skin-minerva .mw-parser-output .infobox-below{text-align:center}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}html.skin-theme-clientpref-night .mw-parser-output .infobox td div:not(.notheme)[style]{background:transparent!important;color:var(--color-base,#202122)}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox td div:not(.notheme)[style]{background:transparent!important;color:var(--color-base,#202122)}}html.skin-theme-clientpref-night .mw-parser-output .infobox td div.NavHead:not(.notheme)[style]{background:transparent!important}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox td div.NavHead:not(.notheme)[style]{background:transparent!important}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="國際非專利藥名（INN）：替格瑞洛">替格瑞洛</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/File:Ticagrelor.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0f/Ticagrelor.svg/200px-Ticagrelor.svg.png" decoding="async" width="200" height="123" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0f/Ticagrelor.svg/300px-Ticagrelor.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0f/Ticagrelor.svg/400px-Ticagrelor.svg.png 2x" data-file-width="620" data-file-height="381" /></a></span></td></tr><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/File:Ticagrelor_ball-and-stick_animation.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ticagrelor_ball-and-stick_animation.gif/200px-Ticagrelor_ball-and-stick_animation.gif" decoding="async" width="200" height="124" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ticagrelor_ball-and-stick_animation.gif/300px-Ticagrelor_ball-and-stick_animation.gif 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ticagrelor_ball-and-stick_animation.gif/400px-Ticagrelor_ball-and-stick_animation.gif 2x" data-file-width="536" data-file-height="332" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;">臨床資料</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><span class="ilh-all" data-orig-title="藥物命名法" data-lang-code="en" data-lang-name="英语" data-foreign-title="Drug nomenclature"><span class="ilh-page"><a href="/w/index.php?title=%E8%97%A5%E7%89%A9%E5%91%BD%E5%90%8D%E6%B3%95&action=edit&redlink=1" class="new" title="藥物命名法（页面不存在）">商品名</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Drug_nomenclature" class="extiw" title="en:Drug nomenclature"><span lang="en" dir="auto">Drug nomenclature</span></a></span>）</span></span></th><td class="infobox-data" style="">Brilinta, Brilique, Possia</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;">其他名稱</th><td class="infobox-data" style="">AZD-6140</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%BE%8E%E5%9C%8B%E8%A1%9B%E7%94%9F%E7%B3%BB%E7%B5%B1%E8%97%A5%E5%B8%AB%E5%8D%94%E6%9C%83" title="美國衛生系統藥師協會">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data" style=""><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/Ticagrelor.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data" style=""><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a611050.html">a611050</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E9%86%AB%E7%99%82%E7%94%A2%E5%93%81%E6%B3%95%E5%BE%8B%E8%A6%8F%E7%AF%84" title="醫療產品法律規範">核准狀況</a></th><td class="infobox-data" style=""><div class="plainlist"> <ul><li><small><abbr title="欧盟">歐</abbr></small> <a href="/wiki/%E6%AC%A7%E6%B4%B2%E8%8D%AF%E5%93%81%E7%AE%A1%E7%90%86%E5%B1%80" title="欧洲药品管理局">EMA</a>: <span title="www.ema.europa.eu"><a rel="nofollow" class="external text" href="http://www.ema.europa.eu/ema/index.jsp?curl=%2Fpages%2Fmedicines%2Flanding%2Fepar_search.jsp&mid=&searchTab=searchByKey&alreadyLoaded=true&isNewQuery=true&status=Authorised&status=Withdrawn&status=Suspended&status=Refused&keywordSearch=Submit&searchType=name&taxonomyPath=&treeNumber=&searchGenericType=generics&keyword=yes">yes</a></span></li> <li><small><abbr title="美国">美</abbr></small> <span title="www.accessdata.fda.gov"><a href="/wiki/%E7%BE%8E%E5%9B%BD%E9%A3%9F%E5%93%81%E8%8D%AF%E5%93%81%E7%9B%91%E7%9D%A3%E7%AE%A1%E7%90%86%E5%B1%80" title="美国食品药品监督管理局">FDA</a>: <a rel="nofollow" class="external text" href="http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.SearchAction&SearchTerm=Ticagrelor&SearchType=BasicSearch">Ticagrelor</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%BB%99%E8%8D%AF%E9%80%94%E5%BE%84" title="给药途径">给药途径</a></th><td class="infobox-data" style="">Oral</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E8%A7%A3%E5%89%96%E5%AD%A6%E6%B2%BB%E7%96%97%E5%AD%A6%E5%8F%8A%E5%8C%96%E5%AD%A6%E5%88%86%E7%B1%BB%E7%B3%BB%E7%BB%9F" title="解剖学治疗学及化学分类系统">ATC碼</a></th><td class="infobox-data" style=""><style data-mw-deduplicate="TemplateStyles:r82655520">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><a href="/wiki/ATC%E4%BB%A3%E7%A0%81_(B01)" title="ATC代码 (B01)">B01AC24</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=B01AC24">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;">法律規範狀態</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E9%86%AB%E7%99%82%E7%94%A2%E5%93%81%E6%B3%95%E5%BE%8B%E8%A6%8F%E7%AF%84" title="醫療產品法律規範">法律規範</a></th><td class="infobox-data" style=""><div class="plainlist"> <ul><li><small><abbr title="美国">美</abbr>：</small><a href="/wiki/%E8%99%95%E6%96%B9%E8%97%A5" title="處方藥">处方药（<span class="Unicode">℞</span>-only）</a></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;"><a href="/wiki/%E8%8D%AF%E7%89%A9%E4%BB%A3%E8%B0%A2%E5%8A%A8%E5%8A%9B%E5%AD%A6" title="药物代谢动力学">藥物動力學</a>數據</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%94%9F%E7%89%A9%E5%88%A9%E7%94%A8%E5%BA%A6" title="生物利用度">生物利用度</a></th><td class="infobox-data" style="">36%</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E8%A1%80%E6%B5%86%E8%9B%8B%E7%99%BD%E7%BB%93%E5%90%88" title="血浆蛋白结合">血漿蛋白結合率</a></th><td class="infobox-data" style="">>99.7%</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E8%8D%AF%E7%89%A9%E4%BB%A3%E8%B0%A2" title="药物代谢">药物代谢</a></th><td class="infobox-data" style=""><a href="/w/index.php?title=Hepatic&action=edit&redlink=1" class="new" title="Hepatic（页面不存在）">Hepatic</a> (<a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a>)</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%94%9F%E7%89%A9%E5%8D%8A%E8%A1%B0%E6%9C%9F" title="生物半衰期">生物半衰期</a></th><td class="infobox-data" style="">7 hrs (ticagrelor), 8.5 hrs (<a href="/wiki/Active_metabolite" class="mw-redirect" title="Active metabolite">active metabolite</a> AR-C124910XX)</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E6%8E%92%E6%B3%84%E4%BD%9C%E7%94%A8" title="排泄作用">排泄途徑</a></th><td class="infobox-data" style=""><a href="/w/index.php?title=Biliary&action=edit&redlink=1" class="new" title="Biliary（页面不存在）">Biliary</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;">识别信息</th></tr><tr><td colspan="2" class="infobox-full-data" style=""><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC%E5%91%BD%E5%90%8D%E6%B3%95" title="IUPAC命名法">IUPAC命名法</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">(1<i>S</i>,2<i>S</i>,3<i>R</i>,5<i>S</i>)-3-[7-[(1<i>R</i>,2<i>S</i>)-2-(3,4-Difluorophenyl)cyclopropylamino]-5-(propylthio)- 3<i>H</i>-[1,2,3]triazolo[4,5-<i>d</i>]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol</div></li><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;"></div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/CAS%E5%8F%B7" title="CAS号">CAS号</a></th><td class="infobox-data" style=""><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=274693-27-5">274693-27-5</a></span> <sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/PubChem" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/9871419">9871419</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1765">1765</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.8047109.html">8047109</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%89%B9%E6%AE%8A%E6%88%90%E5%88%86%E6%A8%99%E8%AD%98" title="特殊成分標識">UNII</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/GLH0314RVC">GLH0314RVC</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D09017">D09017</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL398435">ChEMBL398435</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><span class="ilh-all" data-orig-title="CompTox化学品仪表板" data-lang-code="en" data-lang-name="英语" data-foreign-title="CompTox Chemicals Dashboard"><span class="ilh-page"><a href="/w/index.php?title=CompTox%E5%8C%96%E5%AD%A6%E5%93%81%E4%BB%AA%E8%A1%A8%E6%9D%BF&action=edit&redlink=1" class="new" title="CompTox化学品仪表板（页面不存在）">CompTox Dashboard</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/CompTox_Chemicals_Dashboard" class="extiw" title="en:CompTox Chemicals Dashboard"><span lang="en" dir="auto">CompTox Chemicals Dashboard</span></a></span>）</span></span> <span style="font-weight:normal">(<abbr title="美国国家环境保护局">EPA</abbr>)</span></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID901009337">DTXSID901009337</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q420542#P3117" title="編輯維基數據鏈接"><img alt="編輯維基數據鏈接" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E6%AD%90%E6%B4%B2%E5%8C%96%E5%AD%B8%E5%93%81%E7%AE%A1%E7%90%86%E5%B1%80" title="歐洲化學品管理局"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data" style=""><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.114.746">100.114.746</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q420542#P2566" title="編輯維基數據鏈接"><img alt="編輯維基數據鏈接" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;">化学信息</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E5%8C%96%E5%AD%A6%E5%BC%8F" title="化学式">化学式</a></th><td class="infobox-data" style=""><span title="Carbon">C</span><sub>23</sub><span title="Hydrogen">H</span><sub>28</sub><span title="Fluorine">F</span><sub>2</sub><span title="Nitrogen">N</span><sub>6</sub><span title="Oxygen">O</span><sub>4</sub><span title="Sulfur">S</span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E6%91%A9%E5%B0%94%E8%B4%A8%E9%87%8F" title="摩尔质量">摩尔质量</a></th><td class="infobox-data" style="">522.567 g/mol</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;">3D模型（<span class="ilh-all" data-orig-title="JSmol" data-lang-code="en" data-lang-name="英语" data-foreign-title="JSmol"><span class="ilh-page"><a href="/w/index.php?title=JSmol&action=edit&redlink=1" class="new" title="JSmol（页面不存在）">JSmol</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/JSmol" class="extiw" title="en:JSmol"><span lang="en" dir="auto">JSmol</span></a></span>）</span></span>）</th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CCCSC1%3DNC%28%3DC2C%28%3DN1%29N%28N%3DN2%29%5BC%40%40H%5D3C%5BC%40%40H%5D%28%5BC%40H%5D%28%5BC%40H%5D3O%29O%29OCCO%29N%5BC%40%40H%5D4C%5BC%40H%5D4C5%3DCC%28%3DC%28C%3DC5%29F%29F">交互式图像</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data" style=""><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/%E7%AE%80%E5%8C%96%E5%88%86%E5%AD%90%E7%BA%BF%E6%80%A7%E8%BE%93%E5%85%A5%E8%A7%84%E8%8C%83" title="简化分子线性输入规范">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data" style=""><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/%E5%9B%BD%E9%99%85%E5%8C%96%E5%90%88%E7%89%A9%E6%A0%87%E8%AF%86" title="国际化合物标识">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1<sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:OEKWJQXRCDYSHL-FNOIDJSQSA-N<sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></div></li></ul> </div></td></tr></tbody></table> <p><b>替格瑞洛</b>（<a href="/wiki/INN" class="mw-redirect" title="INN">INN</a>：ticagrelor）商品名<b>倍林达</b><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>（Brilinta）、<b>百無凝</b><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>，是一种<a href="/wiki/%E8%A1%80%E5%B0%8F%E6%9D%BF" title="血小板">血小板</a>聚集抑制剂，可用于预防<a href="/wiki/%E6%80%A5%E6%80%A7%E5%86%A0%E7%8A%B6%E5%8A%A8%E8%84%89%E7%BB%BC%E5%90%88%E5%BE%81" title="急性冠状动脉综合征">急性冠状动脉综合征</a>患者发生<a href="/wiki/%E4%B8%AD%E9%A3%8E" class="mw-redirect" title="中风">中风</a>、<a href="/wiki/%E5%BF%83%E8%82%8C%E6%A2%97%E6%AD%BB" title="心肌梗死">心肌梗死</a><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>。替格瑞洛外形为圆形、双凸、黄色包衣片，一面刻有“T”，其上方刻有“90”字样，另一面光滑，含90mg的替格瑞洛。 </p><p>替格瑞洛临床疗效和安全性已得到血小板抑制和患者后果结局研究（PLATO研究）<sup id="cite_ref-#1_4-0" class="reference"><a href="#cite_note-#1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>及其多项亚组研究2-11的验证和支持。PLATO研究也显示替格瑞洛的疗效明显优于<a href="/wiki/%E6%B0%AF%E5%90%A1%E6%A0%BC%E9%9B%B7" title="氯吡格雷">氯吡格雷</a><sup id="cite_ref-#1_4-1" class="reference"><a href="#cite_note-#1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>，所以被国内外多个指南列于一线推荐<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup>，且欧洲指南更是在近两年将替格瑞洛的推荐级别列于氯吡格雷之前，在替格瑞洛不能使用的患者中才能使用氯吡格雷<sup id="cite_ref-#2_15-0" class="reference"><a href="#cite_note-#2-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup>。由于替格瑞洛与<a href="/w/index.php?title=%E5%99%BB%E5%90%A9%E5%B9%B6%E5%90%A1%E5%95%B6&action=edit&redlink=1" class="new" title="噻吩并吡啶（页面不存在）">噻吩并吡啶</a>类药物（氯吡格雷）是一种不同化学分类的药物，因此将之前的中文用名“替卡格雷”更换为“替格瑞洛”。 </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="简介"><span id=".E7.AE.80.E4.BB.8B"></span>简介</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=1" title="编辑章节：简介"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>替格瑞洛是一种环戊基三唑嘧啶类（CPTP）口服抗血小板药物，ATC代码为B01AC24。该药物最早由<a href="/wiki/%E9%98%BF%E6%96%AF%E5%88%A9%E5%BA%B7" title="阿斯利康">阿斯利康</a>研发，于2011年7月在美国上市<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup>。替格瑞洛为非前体药，无须经肝脏代谢激活即可直接起效，与P2Y12 ADP受体可逆性结合<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-#3_18-0" class="reference"><a href="#cite_note-#3-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup>。PLATO研究结果显示<sup id="cite_ref-#1_4-2" class="reference"><a href="#cite_note-#1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>，替格瑞洛治疗12个月在不增加主要出血的情况下，较<a href="/wiki/%E6%B0%AF%E5%90%A1%E6%A0%BC%E9%9B%B7" title="氯吡格雷">氯吡格雷</a>进一步显著降低急性冠脉综合征（ACS）患者的心血管死亡/心肌梗死/卒中复合终点事件风险达16%，同时显著降低心血管死亡达21%。基于替格瑞洛治疗给ACS患者带来的获益，已有相关医学指南均推荐，替格瑞洛用于ACS患者的抗血小板治疗。而在<span class="ilh-all" data-orig-title="欧洲心脏病协会" data-lang-code="en" data-lang-name="英语" data-foreign-title="European_Society_of_Cardiology"><span class="ilh-page"><a href="/w/index.php?title=%E6%AC%A7%E6%B4%B2%E5%BF%83%E8%84%8F%E7%97%85%E5%8D%8F%E4%BC%9A&action=edit&redlink=1" class="new" title="欧洲心脏病协会（页面不存在）">欧洲心脏病协会</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/European_Society_of_Cardiology" class="extiw" title="en:European Society of Cardiology"><span lang="en" dir="auto">European_Society_of_Cardiology</span></a></span>）</span></span>的两个权威指南（2011年ESC NSTE-ACS 指南<sup id="cite_ref-#2_15-1" class="reference"><a href="#cite_note-#2-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup>和2012年的STEMI指南<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup>）中更是指出，在不能接受替格瑞洛治疗的患者中才能使用氯吡格雷，也充分显示了对于新药进一步降低死亡率的认可。 </p> <div class="mw-heading mw-heading2"><h2 id="药理毒理"><span id=".E8.8D.AF.E7.90.86.E6.AF.92.E7.90.86"></span>药理毒理</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=2" title="编辑章节：药理毒理"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="药效学特性"><span id=".E8.8D.AF.E6.95.88.E5.AD.A6.E7.89.B9.E6.80.A7"></span>药效学特性</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=3" title="编辑章节：药效学特性"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>替格瑞洛，为化学分类环戊基三唑嘧啶（CPTP）的一员， CPTP是一种选择性二磷酸腺苷（ADP）受体拮抗剂，作用于P2Y12ADP受体，以抑制ADP介导的血小板活化和聚集，与噻吩并吡啶类药物（如氯吡格雷）的作用机制相似。但不同的是，替格瑞洛与血小板P2Y12 ADP受体之间的相互作用具有可逆性，没有构象改变和信号传递，并且在停药后血液中的血小板功能也随之快速恢复<sup id="cite_ref-#3_18-1" class="reference"><a href="#cite_note-#3-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup>。基于替格瑞洛与噻吩并吡啶类药物是一种不同化学分类的药物，因此将之前的中文用名“替卡格雷”更换为“替格瑞洛”。 </p><p>ONSET/OFFSET研究中接受阿司匹林治疗的稳定性冠心病患者中<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup>，替格瑞洛显示出快速起效的药理作用，替格瑞洛180mg负荷剂量给药0.5小时后平均血小板聚集抑制（IPA）达41%，给药2－4小时后达到最大的IPA作用89%，此作用可保持2－8小时。 </p> <div class="mw-heading mw-heading3"><h3 id="临床试验"><span id=".E4.B8.B4.E5.BA.8A.E8.AF.95.E9.AA.8C"></span>临床试验</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=4" title="编辑章节：临床试验"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>目前验证替格瑞洛的临床疗效和安全性主要来自于PLATO研究。该研究是一项国际多中心、随机、双盲，双模拟，平行、事件驱动的临床Ⅲ期研究，入组的18624例ACS患者涵盖了全体ACS患者类型（不稳定性心绞痛、非ST段抬高心肌梗死和ST段抬高心肌梗死），及初始接受药物治疗或用经皮冠状动脉介入治疗（PCI），或用冠状动脉旁路移植术（CABG）治疗的患者。头对头地比较了替格瑞洛（负荷剂量180 mg，此后90 mg每日2次）和氯吡格雷（负荷剂量300～600 mg，此后75 mg，每日1次）用于ACS患者的抗血小板治疗的疗效与安全性<sup id="cite_ref-#1_4-3" class="reference"><a href="#cite_note-#1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>。 </p><p>结果显示，在每日使用阿司匹林的背景下，与氯吡格雷相比，替格瑞洛治疗12个月显著降低心血管死亡/心肌梗死/卒中复合终点事件风险达16%，获益主要出现在心血管死亡、心肌梗死这两项指标上，其相对风险分别下降21%和16%。此外，在治疗早期即出现效果（30天时绝对风险下降[ARR]1.0%，相对风险下降[RRR]12%），并且疗效在整个12个月内持续存在。这表明ACS患者使用替格瑞洛治疗长达12个月是合适的<sup id="cite_ref-#1_4-4" class="reference"><a href="#cite_note-#1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>。在PLATO研究的基础上还进行了多项的亚组分析，包括体重、性别、糖尿病病史、短暂性缺血发作或非出血性卒中、或血运重建、合并用药治疗、指示事件的最终诊断和随机时拟进行的治疗途径。这些研究的结果一致证明替格瑞洛的治疗作用优于氯吡格雷2-11。在安全性方面，替格瑞洛组和氯吡格雷组的主要出血发生率相似（分别为11.6%和11.2%，P=0.43）<sup id="cite_ref-#1_4-5" class="reference"><a href="#cite_note-#1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>。 </p><p>根據2019年一項藥物比對的臨床研究<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup>，與替格瑞洛相比，另一款同樣為P2Y<small>12</small>受體拮抗劑的急性冠狀動脈症候群藥物：<a href="/wiki/%E6%99%AE%E6%8B%89%E6%A0%BC%E9%9B%B7" title="普拉格雷">普拉格雷</a>在一年內對於ACS併發的猝死、心肌梗塞、中風等事件，具有顯著意義上較良好的藥效。 </p> <div class="mw-heading mw-heading3"><h3 id="毒理学数据"><span id=".E6.AF.92.E7.90.86.E5.AD.A6.E6.95.B0.E6.8D.AE"></span>毒理学数据</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=5" title="编辑章节：毒理学数据"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>基于常规安全药理学、单次及重复剂量毒理和潜在遗传毒性研究，替格瑞洛及主要代谢产物的临床前数据未显示对人体存在无法接受的不良反应风险。<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="药代动力学特性"><span id=".E8.8D.AF.E4.BB.A3.E5.8A.A8.E5.8A.9B.E5.AD.A6.E7.89.B9.E6.80.A7"></span>药代动力学特性</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=6" title="编辑章节：药代动力学特性"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>替格瑞洛的药代动力学呈线性，直至1260mg，替格瑞洛和活性代谢产物（AR C124910XX）暴露量与剂量基本成正比。<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup>替格瑞洛口服后迅速吸收，中位<a href="/wiki/%E6%9C%80%E5%A4%A7%E8%A1%80%E8%8D%AF%E6%B5%93%E5%BA%A6" title="最大血药浓度">tmax</a>约为1.5小时<sup id="cite_ref-#4_24-0" class="reference"><a href="#cite_note-#4-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup>。由于替格瑞洛为非前体药物，直接作用于P2Y12受体，无须经肝脏代谢激活，可快速生成其主要循环代谢产物AR-C124910XX。药物本身及其代谢产物均有活性，因此不但可快速且强效地抑制ADP介导的血小板聚集，且有效性不受肝脏CYP 2C19基因多态性影响。这一点在临床上非常重要，因为氯吡格雷是一种前体药物，须在肝内通过肝细胞色素P450酶（CYP）的作用下经两步代谢为活性代谢产物方可发挥抑制血小板效应。因此，基因多态性是造成氯吡格雷反应变异性的主要原因之一，导致其抗血小板效应难以预测。而CYP2C19*2等位基因在人群中普遍存在，中国多项调查显示，其在人群中的存在率约在25%~35%之间<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup>。 </p><p>替格瑞洛主要通过肝代谢消除。通过服用放射标记的替格瑞洛，测得放射物的平均回收率约为84%（粪便中含有58%，尿液中含有26%）。替格瑞洛的平均t1/2约为7小时，活性代谢产物为9小时。<sup id="cite_ref-#4_24-1" class="reference"><a href="#cite_note-#4-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup>。 </p> <div class="mw-heading mw-heading2"><h2 id="适应症"><span id=".E9.80.82.E5.BA.94.E7.97.87"></span>适应症</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=7" title="编辑章节：适应症"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>替格瑞洛用于<a href="/wiki/%E6%80%A5%E6%80%A7%E5%86%A0%E7%8A%B6%E5%8A%A8%E8%84%89%E7%BB%BC%E5%90%88%E5%BE%81" title="急性冠状动脉综合征">急性冠脉综合征</a>（不稳定性心绞痛、非ST段抬高心肌梗死或ST段抬高心肌梗死）患者，包括接受药物治疗和<a href="/wiki/%E7%BB%8F%E7%9A%AE%E5%86%A0%E7%8A%B6%E5%8A%A8%E8%84%89%E4%BB%8B%E5%85%A5%E6%B2%BB%E7%96%97" title="经皮冠状动脉介入治疗">经皮冠状动脉介入</a>（PCI）治疗的患者，降低血栓性心血管事件的发生率。与氯吡格雷相比，替格瑞洛可以降低心血管死亡、心肌梗死或卒中复合终点的发生率，两治疗组之间的差异来源于心血管死亡和心肌梗死，而在卒中方面无差异。 </p><p>在ACS患者中，对替格瑞洛与阿司匹林联合用药进行了研究。结果发现，阿司匹林维持剂量大于100mg会降低替格瑞洛减少复合终点事件的临床疗效，因此，阿司匹林的维持剂量不能超过每日100mg。 </p> <div class="mw-heading mw-heading2"><h2 id="用法用量"><span id=".E7.94.A8.E6.B3.95.E7.94.A8.E9.87.8F"></span>用法用量</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=8" title="编辑章节：用法用量"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>口服。替格瑞洛可在饭前或饭后服用。替格瑞洛起始剂量为单次负荷量180mg（90 mg×2片），此后每次1片（90mg），每日两次。除非有明确禁忌，替格瑞洛应与阿司匹林联合用药。在服用首剂负荷阿司匹林后，阿司匹林的维持剂量为每日1次，每次75～100mg。 </p><p>已经接受过负荷剂量氯吡格雷的ACS患者，可以开始使用替格瑞洛。 </p><p>治疗中应尽量避免漏服。如果患者漏服了一剂，应在预定的下次服药时间服用一片90mg（患者的下一个剂量）。 </p><p>替格瑞洛的治疗时间可长达12个月，除非有临床指征需要中止替格瑞洛治疗(例如進行手術或大出血的風險)。超过12个月的用药经验目前尚有限。急性冠脉综合征患者过早中止任何抗血小板药物（包括替格瑞洛）治疗，可能会使基础病引起的心血管死亡或心肌梗死的风险增加，因此，应避免过早中止治疗。但目前認為阿司匹靈合用替格瑞洛在3個月後，可停用阿司匹靈，可降低更多不良反應。 </p><p>臨床試驗證實了急性冠狀動脈綜合症狀患者應用阿司匹靈聯合Clopidogrel治療的益處。但在美國，Clopidogrel依然是最常使用的P2Y12註2抑製劑，但事實上已在試驗中證明治療方面，下一代P2Y12抑製劑（例如prasugrel 或替格瑞洛）比Clopidogrel來得好，因此在歐洲和美國的臨床建議均支持使用更加有效的下一代P2Y12抑製劑。這些藥物的起效時間快，其血小板的抑制作用更有效且更容易預測，並且藥物之間相互影響情形較少。對於病人及醫生的評估較有幫助，因此在非STE急性冠狀動脈綜合症狀治療中已經優先建議使用prasugrel 或替格瑞洛作為所有急性冠狀動脈綜合症狀患者的治療首選。 </p><p>相比prasugrel ，替格瑞洛停藥率高（原因有可能與ticagrelor相關的副作用，如呼吸困難），所以並不能完整地去比較兩者用藥情形，但ESC指南仍建議，對於接受PCI<sub>註3</sub>的非STE急性冠脈綜合症狀患者，應建議使用prasugrel，而不是ticagrelor。 </p> <div class="mw-heading mw-heading2"><h2 id="不良反应"><span id=".E4.B8.8D.E8.89.AF.E5.8F.8D.E5.BA.94"></span>不良反应</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=9" title="编辑章节：不良反应"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>在1万例患者中对替格瑞洛片的安全性进行了评价，其中包括治疗期超过1年的3千多例患者。在替格瑞洛治疗的患者中，最常报告的不良反应为呼吸困难、挫伤和鼻出血，这些事件的发生率高于氯吡格雷组患者。 </p><p>其他常见不良反应为：胃肠道出血，皮下或真皮出血，瘀斑以及操作部位出血，偶见不良反应为：颅内出血、头晕头痛、眼出血、咯血、呕血、胃肠道溃疡出血、痔疮出血、胃炎、口腔出血、呕吐、腹泻、腹痛、恶心、消化不良、瘙痒、皮疹及尿道和阴道出血、操作后出血；罕见不良反应为：高尿酸血症、意识混乱、感觉异常、耳出血、眩晕、腹膜后出血、便秘、关节积血、血肌酐升高、伤口出血、创伤性出血。在PLATO研究中，替格瑞洛组急性期出现室性间歇的患者为6.0%；1个月后室性间歇的发生率为2.2%。 </p> <div class="mw-heading mw-heading2"><h2 id="禁忌症"><span id=".E7.A6.81.E5.BF.8C.E7.97.87"></span>禁忌症</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=10" title="编辑章节：禁忌症"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>对替格瑞洛或替格瑞洛任何辅料成分过敏者；活动性病理性出血（如消化性溃疡或颅内出血）的患者；有颅内出血病史者；中、重度肝脏损害患者；因联合用药可导致替格瑞洛的暴露量大幅度增加，禁止替格瑞洛片与强效CYP3A4抑制剂（如：酮康唑、克拉霉素、奈法唑酮、利托那韦和阿扎那韦）联合用药。 </p> <div class="mw-heading mw-heading2"><h2 id="注意事项"><span id=".E6.B3.A8.E6.84.8F.E4.BA.8B.E9.A1.B9"></span>注意事项</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=11" title="编辑章节：注意事项"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>有出血倾向（例如近期创伤、近期手术、凝血功能障碍、活动性或近期胃肠道出血）的患者慎用替格瑞洛。 </p><p>在服用替格瑞洛片后24小时内联合使用其它可能增加出血风险药品（例如：用<a href="/wiki/%E9%9D%9E%E7%94%BE%E4%BD%93%E6%8A%97%E7%82%8E%E8%8D%AF" title="非甾体抗炎药">非甾体抗炎药</a>、口服抗凝血药和/或纤溶剂）的患者，慎用替格瑞洛。对于实施择期手术的患者，如果抗血小板药物治疗不是必须的，应在术前7天停止使用替格瑞洛。心动过缓事件风险很大的患者（例如患有病态窦房结综合征、2度或3度房室传导阻滞或心动过缓相关晕厥但未装起搏器的患者）需要谨慎使用替格瑞洛。有哮喘和/或COPD病史的患者应慎用替格瑞洛。应避免中断替格瑞洛片治疗。如果必须暂时停用替格瑞洛（如治疗出血或择期外科手术），则应尽快重新开始给予治疗。停用替格瑞洛将会增加心肌梗死、支架血栓和死亡的风险。 </p> <div class="mw-heading mw-heading2"><h2 id="参考资料"><span id=".E5.8F.82.E8.80.83.E8.B5.84.E6.96.99"></span>参考资料</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&action=edit&section=12" title="编辑章节：参考资料"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="reflist columns references-column-count references-column-count-3" style="-moz-column-count: 3; -webkit-column-count: 3; column-count: 3; list-style-type: decimal;"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external free" href="http://116.62.121.189/docs/Brilinta-Leaflet-IDL-60mg%2090mg-CN-PS10352.pdf">http://116.62.121.189/docs/Brilinta-Leaflet-IDL-60mg%2090mg-CN-PS10352.pdf</a></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external free" href="https://www1.ndmctsgh.edu.tw/pharm/pic/medinsert/005BRI08.pdf">https://www1.ndmctsgh.edu.tw/pharm/pic/medinsert/005BRI08.pdf</a></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text">Fuller R, Chavez B. Ticagrelor (brilinta), an antiplatelet drug for acute coronary syndrome. P T. 2012 Oct;37(10):562-8. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/23115464?dopt=Abstract">PMID 23115464</a>; PMCID: PMC3474441.</span> </li> <li id="cite_note-#1-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-#1_4-0"><sup><b>4.0</b></sup></a> <a href="#cite_ref-#1_4-1"><sup><b>4.1</b></sup></a> <a href="#cite_ref-#1_4-2"><sup><b>4.2</b></sup></a> <a href="#cite_ref-#1_4-3"><sup><b>4.3</b></sup></a> <a href="#cite_ref-#1_4-4"><sup><b>4.4</b></sup></a> <a href="#cite_ref-#1_4-5"><sup><b>4.5</b></sup></a></span> <span class="reference-text">1.Wallentin L,et al. N Engl J Med. 2009 Sep 10;361(11):1045-57.</span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text">2.Cannon CP，,et al. Lancet. 2010 Jan 23;375(9711):283-93. </span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text">3.Steg PG,et al. Circulation. 2010 Nov 23;122(21):2131-41.</span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text">4.James S，et al. Eur Heart J. 2010 Dec;31(24):3006-16.</span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text">5.Held C，et al. J Am Coll Cardiol. 2011 Feb 8;57(6):672-84.</span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text">6.James SK,et al.BMJ. 2011 Jun 17;342:d3527.</span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text">7.Mahaffey KW，et al. Circulation. 2011 Aug 2;124(5):544-54</span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text">8.James S，et al. Circulation. 2010 Sep 14;122(11):1056-67.</span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text">9.Mahaffey KW，et al. Circulation. 2011 Aug 2;124(5):544-54.</span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text">10.Storey RF，et al. J Am Coll Cardiol. 2010 Oct 26;56(18):1456-62.</span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text">11.Storey RF，et al. Eur Heart J. 2011 Dec;32(23):2945-53.</span> </li> <li id="cite_note-#2-15"><span class="mw-cite-backlink">^ <a href="#cite_ref-#2_15-0"><sup><b>15.0</b></sup></a> <a href="#cite_ref-#2_15-1"><sup><b>15.1</b></sup></a></span> <span class="reference-text">18.Hamm CW, et al. Eur Heart J. 2011 Dec;32(23):2999-3054.</span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><cite class="citation web"><a rel="nofollow" class="external text" href="https://www.bjnews.com.cn/detail/1724233719168964.html">华海药业替格瑞洛片在美获批，用于治疗血栓</a>. 新京报. 2024-08-21 <span class="reference-accessdate"> [<span class="nowrap">2024-08-21</span>]</span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&rft.atitle=%E5%8D%8E%E6%B5%B7%E8%8D%AF%E4%B8%9A%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B%E7%89%87%E5%9C%A8%E7%BE%8E%E8%8E%B7%E6%89%B9%EF%BC%8C%E7%94%A8%E4%BA%8E%E6%B2%BB%E7%96%97%E8%A1%80%E6%A0%93&rft.date=2024-08-21&rft.genre=unknown&rft.jtitle=%E6%96%B0%E4%BA%AC%E6%8A%A5&rft_id=https%3A%2F%2Fwww.bjnews.com.cn%2Fdetail%2F1724233719168964.html&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text">22.Schomig A. N Engl J Med. 2009 Sep 10;361(11):1108-11.</span> </li> <li id="cite_note-#3-18"><span class="mw-cite-backlink">^ <a href="#cite_ref-#3_18-0"><sup><b>18.0</b></sup></a> <a href="#cite_ref-#3_18-1"><sup><b>18.1</b></sup></a></span> <span class="reference-text">23.Becker RC, et al. Thromb Haemost. 2010 Mar;103(3):535-44.</span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text">19.Steg PG, et al. Eur Heart J. 2012 Oct;33(20):2569-619.</span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text">24.Gurbel PA et al. Circulation. 2009 Dec 22;120(25):2577-85.</span> </li> <li id="cite_note-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-21">^</a></b></span> <span class="reference-text">1. Stefanie Schüpke, M.D.N Engl J Med 2019; 381:1524-1534 DOI: 10.1056/NEJMoa1908973</span> </li> <li id="cite_note-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-22">^</a></b></span> <span class="reference-text">25.SUMMARY OF PRODUCT CHARACTERISTICS. <a rel="nofollow" class="external free" href="http://www.ema.europa.eu/">http://www.ema.europa.eu/</a> （<a rel="nofollow" class="external text" href="//web.archive.org/web/20201215233423/http://www.ema.europa.eu/">页面存档备份</a>，存于<a href="/wiki/%E4%BA%92%E8%81%94%E7%BD%91%E6%A1%A3%E6%A1%88%E9%A6%86" title="互联网档案馆">互联网档案馆</a>）</span> </li> <li id="cite_note-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-23">^</a></b></span> <span class="reference-text">26.Butler K, et al. J Clin Pharmacol. 2011 Jul;51(7):978-87.</span> </li> <li id="cite_note-#4-24"><span class="mw-cite-backlink">^ <a href="#cite_ref-#4_24-0"><sup><b>24.0</b></sup></a> <a href="#cite_ref-#4_24-1"><sup><b>24.1</b></sup></a></span> <span class="reference-text">27.PRODUCT PROFILER: Brilinta™ (ticagrelor) Tablets. P T. 2012 April; 37(4 section 2): 4–18.</span> </li> <li id="cite_note-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-25">^</a></b></span> <span class="reference-text">28.Rosemary J, et al. Curr Clin Pharmacol. 2007 Jan;2(1):93-109.</span> </li> </ol></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r84265675">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:" :"}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist-pipe dd::after,.mw-parser-output .hlist-pipe li::after{content:" | ";font-weight:normal}.mw-parser-output .hlist-hyphen dd::after,.mw-parser-output .hlist-hyphen li::after{content:" - ";font-weight:normal}.mw-parser-output .hlist-comma dd::after,.mw-parser-output .hlist-comma li::after{content:"、";font-weight:normal}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:"（"counter(listitem)"\a0 "}.mw-parser-output ul.cslist,.mw-parser-output ul.sslist{margin:0;padding:0;display:inline-block;list-style:none}.mw-parser-output .cslist li,.mw-parser-output .sslist li{margin:0;display:inline-block}.mw-parser-output .cslist li::after{content:"，"}.mw-parser-output .sslist li::after{content:"；"}.mw-parser-output .cslist li:last-child::after,.mw-parser-output .sslist li:last-child::after{content:none}</style><style data-mw-deduplicate="TemplateStyles:r84261037">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{text-align:center;padding-left:1em;padding-right:1em}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf;position:relative}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em;width:auto;padding-left:0.2em;position:absolute;left:1em}.mw-parser-output .navbox .mw-collapsible-toggle{margin-left:0.5em;position:absolute;right:1em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><style data-mw-deduplicate="TemplateStyles:r84244141">.mw-parser-output .navbar{display:inline;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:110%;margin:0 8em}.mw-parser-output .navbar-ct-mini{font-size:110%;margin:0 5em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="抗血栓药（英语：-&#123;Antithrombotic&#125;-）（溶血栓药（英语：-&#123;Thrombolytic_drug&#125;-）、抗凝剂与抗血小板药（英语：-&#123;antiplatelet_drug&#125;-））（B01）" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="collapsible-title navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84244141"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:%E6%8A%97%E8%A1%80%E6%A0%93%E8%8D%AF" title="Template:抗血栓药"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:%E6%8A%97%E8%A1%80%E6%A0%93%E8%8D%AF" title="Template talk:抗血栓药"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:%E6%8A%97%E8%A1%80%E6%A0%93%E8%8D%AF" title="Special:编辑页面/Template:抗血栓药"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="抗血栓药（英语：-&#123;Antithrombotic&#125;-）（溶血栓药（英语：-&#123;Thrombolytic_drug&#125;-）、抗凝剂与抗血小板药（英语：-&#123;antiplatelet_drug&#125;-））（B01）" style="font-size:110%;margin:0 5em"><span class="ilh-all" data-orig-title="抗血栓药" data-lang-code="en" data-lang-name="英语" data-foreign-title="Antithrombotic"><span class="ilh-page"><a href="/w/index.php?title=%E6%8A%97%E8%A1%80%E6%A0%93%E8%8D%AF&action=edit&redlink=1" class="new" title="抗血栓药（页面不存在）">抗血栓药</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Antithrombotic" class="extiw" title="en:Antithrombotic"><span lang="en" dir="auto">Antithrombotic</span></a></span>）</span></span>（<span class="ilh-all" data-orig-title="溶血栓药" data-lang-code="en" data-lang-name="英语" data-foreign-title="Thrombolytic drug"><span class="ilh-page"><a href="/w/index.php?title=%E6%BA%B6%E8%A1%80%E6%A0%93%E8%8D%AF&action=edit&redlink=1" class="new" title="溶血栓药（页面不存在）">溶血栓药</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Thrombolytic_drug" class="extiw" title="en:Thrombolytic drug"><span lang="en" dir="auto">Thrombolytic drug</span></a></span>）</span></span>、<a href="/wiki/%E6%8A%97%E5%87%9D%E5%89%82" title="抗凝剂">抗凝剂</a>与<span class="ilh-all" data-orig-title="抗血小板药" data-lang-code="en" data-lang-name="英语" data-foreign-title="antiplatelet drug"><span class="ilh-page"><a href="/w/index.php?title=%E6%8A%97%E8%A1%80%E5%B0%8F%E6%9D%BF%E8%8D%AF&action=edit&redlink=1" class="new" title="抗血小板药（页面不存在）">抗血小板药</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/antiplatelet_drug" class="extiw" title="en:antiplatelet drug"><span lang="en" dir="auto">antiplatelet drug</span></a></span>）</span></span>）（<a href="/wiki/ATC%E4%BB%A3%E7%A0%81_(B01)" title="ATC代码 (B01)">B01</a>）</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:MistyRose;"><span class="ilh-all" data-orig-title="抗血小板药" data-lang-code="en" data-lang-name="英语" data-foreign-title="Antiplatelet drug"><span class="ilh-page"><a href="/w/index.php?title=%E6%8A%97%E8%A1%80%E5%B0%8F%E6%9D%BF%E8%8D%AF&action=edit&redlink=1" class="new" title="抗血小板药（页面不存在）">抗血小板药</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Antiplatelet_drug" class="extiw" title="en:Antiplatelet drug"><span lang="en" dir="auto">Antiplatelet drug</span></a></span>）</span></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><span class="ilh-all" data-orig-title="糖蛋白IIb／IIIa抑制剂" data-lang-code="en" data-lang-name="英语" data-foreign-title="Glycoprotein IIb/IIIa inhibitors"><span class="ilh-page"><a href="/w/index.php?title=%E7%B3%96%E8%9B%8B%E7%99%BDIIb%EF%BC%8FIIIa%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="糖蛋白IIb／IIIa抑制剂（页面不存在）">糖蛋白IIb／IIIa<br />抑制剂</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Glycoprotein_IIb/IIIa_inhibitors" class="extiw" title="en:Glycoprotein IIb/IIIa inhibitors"><span lang="en" dir="auto">Glycoprotein IIb/IIIa inhibitors</span></a></span>）</span></span>类</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="阿昔单抗" data-lang-code="en" data-lang-name="英语" data-foreign-title="Abciximab"><span class="ilh-page"><a href="/w/index.php?title=%E9%98%BF%E6%98%94%E5%8D%95%E6%8A%97&action=edit&redlink=1" class="new" title="阿昔单抗（页面不存在）">阿昔单抗</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Abciximab" class="extiw" title="en:Abciximab"><span lang="en" dir="auto">Abciximab</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="依替巴肽" data-lang-code="en" data-lang-name="英语" data-foreign-title="Eptifibatide"><span class="ilh-page"><a href="/w/index.php?title=%E4%BE%9D%E6%9B%BF%E5%B7%B4%E8%82%BD&action=edit&redlink=1" class="new" title="依替巴肽（页面不存在）">依替巴肽</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Eptifibatide" class="extiw" title="en:Eptifibatide"><span lang="en" dir="auto">Eptifibatide</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="替罗非班" data-lang-code="en" data-lang-name="英语" data-foreign-title="Tirofiban"><span class="ilh-page"><a href="/w/index.php?title=%E6%9B%BF%E7%BD%97%E9%9D%9E%E7%8F%AD&action=edit&redlink=1" class="new" title="替罗非班（页面不存在）">替罗非班</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Tirofiban" class="extiw" title="en:Tirofiban"><span lang="en" dir="auto">Tirofiban</span></a></span>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><span class="ilh-all" data-orig-title="P2Y12" data-lang-code="en" data-lang-name="英语" data-foreign-title="P2Y12"><span class="ilh-page"><a href="/w/index.php?title=P2Y12&action=edit&redlink=1" class="new" title="P2Y12（页面不存在）">ADP受体／P2Y<sub>12</sub></a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/P2Y12" class="extiw" title="en:P2Y12"><span lang="en" dir="auto">P2Y12</span></a></span>）</span></span><span class="ilh-all" data-orig-title="腺苷二磷酸受体抑制剂" data-lang-code="en" data-lang-name="英语" data-foreign-title="Adenosine diphosphate receptor inhibitor"><span class="ilh-page"><a href="/w/index.php?title=%E8%85%BA%E8%8B%B7%E4%BA%8C%E7%A3%B7%E9%85%B8%E5%8F%97%E4%BD%93%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="腺苷二磷酸受体抑制剂（页面不存在）">抑制剂</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Adenosine_diphosphate_receptor_inhibitor" class="extiw" title="en:Adenosine diphosphate receptor inhibitor"><span lang="en" dir="auto">Adenosine diphosphate receptor inhibitor</span></a></span>）</span></span>类</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="噻吩并吡啶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Thienopyridine"><span class="ilh-page"><a href="/w/index.php?title=%E5%99%BB%E5%90%A9%E5%B9%B6%E5%90%A1%E5%95%B6&action=edit&redlink=1" class="new" title="噻吩并吡啶（页面不存在）">噻吩并吡啶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Thienopyridine" class="extiw" title="en:Thienopyridine"><span lang="en" dir="auto">Thienopyridine</span></a></span>）</span></span>（<a href="/wiki/%E6%B0%AF%E5%90%A1%E6%A0%BC%E9%9B%B7" title="氯吡格雷">氯吡格雷</a>、<a href="/wiki/%E6%99%AE%E6%8B%89%E6%A0%BC%E9%9B%B7" title="普拉格雷">普拉格雷</a>、<span class="ilh-all" data-orig-title="噻氯匹啶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ticlopidine"><span class="ilh-page"><a href="/w/index.php?title=%E5%99%BB%E6%B0%AF%E5%8C%B9%E5%95%B6&action=edit&redlink=1" class="new" title="噻氯匹啶（页面不存在）">噻氯匹啶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ticlopidine" class="extiw" title="en:Ticlopidine"><span lang="en" dir="auto">Ticlopidine</span></a></span>）</span></span>）</li> <li><a href="/wiki/%E6%A0%B8%E8%8B%B7%E9%85%B8" title="核苷酸">核苷酸</a>／<a href="/wiki/%E6%A0%B8%E8%8B%B7" title="核苷">核苷</a>类似物（<span class="ilh-all" data-orig-title="坎格雷洛" data-lang-code="en" data-lang-name="英语" data-foreign-title="Cangrelor"><span class="ilh-page"><a href="/w/index.php?title=%E5%9D%8E%E6%A0%BC%E9%9B%B7%E6%B4%9B&action=edit&redlink=1" class="new" title="坎格雷洛（页面不存在）">坎格雷洛</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Cangrelor" class="extiw" title="en:Cangrelor"><span lang="en" dir="auto">Cangrelor</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="依诺格雷" data-lang-code="en" data-lang-name="英语" data-foreign-title="Elinogrel"><span class="ilh-page"><a href="/w/index.php?title=%E4%BE%9D%E8%AF%BA%E6%A0%BC%E9%9B%B7&action=edit&redlink=1" class="new" title="依诺格雷（页面不存在）">依诺格雷</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Elinogrel" class="extiw" title="en:Elinogrel"><span lang="en" dir="auto">Elinogrel</span></a></span>）</span></span>、<a class="mw-selflink selflink">替格瑞洛</a>(替卡格雷)）</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><span class="ilh-all" data-orig-title="前列腺素类似物" data-lang-code="en" data-lang-name="英语" data-foreign-title="Prostaglandin analogue"><span class="ilh-page"><a href="/w/index.php?title=%E5%89%8D%E5%88%97%E8%85%BA%E7%B4%A0%E7%B1%BB%E4%BC%BC%E7%89%A9&action=edit&redlink=1" class="new" title="前列腺素类似物（页面不存在）">前列腺素类似物</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Prostaglandin_analogue" class="extiw" title="en:Prostaglandin analogue"><span lang="en" dir="auto">Prostaglandin analogue</span></a></span>）</span></span>类<br />（<a href="/wiki/%E5%89%8D%E5%88%97%E7%8E%AF%E7%B4%A0" title="前列环素">PGI2</a>）</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="Beraprost" data-lang-code="en" data-lang-name="英语" data-foreign-title="Beraprost"><span class="ilh-page"><a href="/w/index.php?title=Beraprost&action=edit&redlink=1" class="new" title="Beraprost（页面不存在）">Beraprost</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Beraprost" class="extiw" title="en:Beraprost"><span lang="en" dir="auto">Beraprost</span></a></span>）</span></span></li> <li><a href="/wiki/%E5%89%8D%E5%88%97%E7%8E%AF%E7%B4%A0" title="前列环素">前列环素</a></li> <li><span class="ilh-all" data-orig-title="伊洛前列素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Iloprost"><span class="ilh-page"><a href="/w/index.php?title=%E4%BC%8A%E6%B4%9B%E5%89%8D%E5%88%97%E7%B4%A0&action=edit&redlink=1" class="new" title="伊洛前列素（页面不存在）">伊洛前列素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Iloprost" class="extiw" title="en:Iloprost"><span lang="en" dir="auto">Iloprost</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="曲前列环素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Treprostinil"><span class="ilh-page"><a href="/w/index.php?title=%E6%9B%B2%E5%89%8D%E5%88%97%E7%8E%AF%E7%B4%A0&action=edit&redlink=1" class="new" title="曲前列环素（页面不存在）">曲前列环素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Treprostinil" class="extiw" title="en:Treprostinil"><span lang="en" dir="auto">Treprostinil</span></a></span>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><span class="ilh-all" data-orig-title="COX抑制剂" data-lang-code="en" data-lang-name="英语" data-foreign-title="Mechanism of action of aspirin"><span class="ilh-page"><a href="/w/index.php?title=COX%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="COX抑制剂（页面不存在）">COX抑制剂</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Mechanism_of_action_of_aspirin" class="extiw" title="en:Mechanism of action of aspirin"><span lang="en" dir="auto">Mechanism of action of aspirin</span></a></span>）</span></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E4%B9%99%E9%85%B0%E6%B0%B4%E6%9D%A8%E9%85%B8" title="乙酰水杨酸">乙酰水杨酸／阿司匹林</a><sup>#</sup></li> <li><span class="ilh-all" data-orig-title="阿洛普令" data-lang-code="en" data-lang-name="英语" data-foreign-title="Aloxiprin"><span class="ilh-page"><a href="/w/index.php?title=%E9%98%BF%E6%B4%9B%E6%99%AE%E4%BB%A4&action=edit&redlink=1" class="new" title="阿洛普令（页面不存在）">阿洛普令</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Aloxiprin" class="extiw" title="en:Aloxiprin"><span lang="en" dir="auto">Aloxiprin</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="卡巴匹林钙" data-lang-code="en" data-lang-name="英语" data-foreign-title="Carbasalate calcium"><span class="ilh-page"><a href="/w/index.php?title=%E5%8D%A1%E5%B7%B4%E5%8C%B9%E6%9E%97%E9%92%99&action=edit&redlink=1" class="new" title="卡巴匹林钙（页面不存在）">卡巴匹林钙</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Carbasalate_calcium" class="extiw" title="en:Carbasalate calcium"><span lang="en" dir="auto">Carbasalate calcium</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="吲哚布芬" data-lang-code="en" data-lang-name="英语" data-foreign-title="Indobufen"><span class="ilh-page"><a href="/w/index.php?title=%E5%90%B2%E5%93%9A%E5%B8%83%E8%8A%AC&action=edit&redlink=1" class="new" title="吲哚布芬（页面不存在）">吲哚布芬</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Indobufen" class="extiw" title="en:Indobufen"><span lang="en" dir="auto">Indobufen</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="三氟柳" data-lang-code="en" data-lang-name="英语" data-foreign-title="Triflusal"><span class="ilh-page"><a href="/w/index.php?title=%E4%B8%89%E6%B0%9F%E6%9F%B3&action=edit&redlink=1" class="new" title="三氟柳（页面不存在）">三氟柳</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Triflusal" class="extiw" title="en:Triflusal"><span lang="en" dir="auto">Triflusal</span></a></span>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><a href="/wiki/%E5%87%9D%E8%A1%80%E5%99%81%E7%83%B7" class="mw-redirect" title="凝血噁烷">凝血噁烷</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="血栓素合成酶抑制剂" data-lang-code="en" data-lang-name="英语" data-foreign-title="Thromboxane synthase inhibitors"><span class="ilh-page"><a href="/w/index.php?title=%E8%A1%80%E6%A0%93%E7%B4%A0%E5%90%88%E6%88%90%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="血栓素合成酶抑制剂（页面不存在）">血栓素合成酶抑制剂</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Thromboxane_synthase_inhibitors" class="extiw" title="en:Thromboxane synthase inhibitors"><span lang="en" dir="auto">Thromboxane synthase inhibitors</span></a></span>）</span></span>（<a href="/wiki/%E5%8F%8C%E5%98%A7%E8%BE%BE%E8%8E%AB" title="双嘧达莫">双嘧达莫</a>、<span class="ilh-all" data-orig-title="吡考他胺" data-lang-code="en" data-lang-name="英语" data-foreign-title="Picotamide"><span class="ilh-page"><a href="/w/index.php?title=%E5%90%A1%E8%80%83%E4%BB%96%E8%83%BA&action=edit&redlink=1" class="new" title="吡考他胺（页面不存在）">吡考他胺</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Picotamide" class="extiw" title="en:Picotamide"><span lang="en" dir="auto">Picotamide</span></a></span>）</span></span>）</li> <li><span class="ilh-all" data-orig-title="血栓素受体拮抗剂" data-lang-code="en" data-lang-name="英语" data-foreign-title="Thromboxane receptor antagonist"><span class="ilh-page"><a href="/w/index.php?title=%E8%A1%80%E6%A0%93%E7%B4%A0%E5%8F%97%E4%BD%93%E6%8B%AE%E6%8A%97%E5%89%82&action=edit&redlink=1" class="new" title="血栓素受体拮抗剂（页面不存在）">受体拮抗剂</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Thromboxane_receptor_antagonist" class="extiw" title="en:Thromboxane receptor antagonist"><span lang="en" dir="auto">Thromboxane receptor antagonist</span></a></span>）</span></span>（<span class="ilh-all" data-orig-title="Terutroban" data-lang-code="en" data-lang-name="英语" data-foreign-title="Terutroban"><span class="ilh-page"><a href="/w/index.php?title=Terutroban&action=edit&redlink=1" class="new" title="Terutroban（页面不存在）">Terutroban</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Terutroban" class="extiw" title="en:Terutroban"><span lang="en" dir="auto">Terutroban</span></a></span>）</span></span><sup>†</sup>）</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><a href="/wiki/%E7%A3%B7%E9%85%B8%E4%BA%8C%E9%85%AF%E9%85%B6%E6%8A%91%E5%88%B6%E8%8D%AF" title="磷酸二酯酶抑制药">磷酸二酯酶抑制药</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E8%A5%BF%E6%B4%9B%E4%BB%96%E5%94%91" title="西洛他唑">西洛他唑</a></li> <li><a href="/wiki/%E5%8F%8C%E5%98%A7%E8%BE%BE%E8%8E%AB" title="双嘧达莫">双嘧达莫</a></li> <li><span class="ilh-all" data-orig-title="三氟柳" data-lang-code="en" data-lang-name="英语" data-foreign-title="Triflusal"><span class="ilh-page"><a href="/w/index.php?title=%E4%B8%89%E6%B0%9F%E6%9F%B3&action=edit&redlink=1" class="new" title="三氟柳（页面不存在）">三氟柳</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Triflusal" class="extiw" title="en:Triflusal"><span lang="en" dir="auto">Triflusal</span></a></span>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose">其他</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="氯克罗孟" data-lang-code="en" data-lang-name="英语" data-foreign-title="Cloricromen"><span class="ilh-page"><a href="/w/index.php?title=%E6%B0%AF%E5%85%8B%E7%BD%97%E5%AD%9F&action=edit&redlink=1" class="new" title="氯克罗孟（页面不存在）">氯克罗孟</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Cloricromen" class="extiw" title="en:Cloricromen"><span lang="en" dir="auto">Cloricromen</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="地他唑" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ditazole"><span class="ilh-page"><a href="/w/index.php?title=%E5%9C%B0%E4%BB%96%E5%94%91&action=edit&redlink=1" class="new" title="地他唑（页面不存在）">地他唑</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ditazole" class="extiw" title="en:Ditazole"><span lang="en" dir="auto">Ditazole</span></a></span>）</span></span></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:MistyRose;"><a href="/wiki/%E6%8A%97%E5%87%9D%E5%89%82" title="抗凝剂">抗凝剂</a>类</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><a href="/wiki/%E7%BB%B4%E7%94%9F%E7%B4%A0K" title="维生素K">维生素K</a>拮抗剂<br />（抑制<a href="/wiki/%E5%87%9D%E8%A1%80%E9%85%B6" title="凝血酶">II</a>、<span class="ilh-all" data-orig-title="VII因子" data-lang-code="en" data-lang-name="英语" data-foreign-title="Factor VII"><span class="ilh-page"><a href="/w/index.php?title=VII%E5%9B%A0%E5%AD%90&action=edit&redlink=1" class="new" title="VII因子（页面不存在）">VII</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Factor_VII" class="extiw" title="en:Factor VII"><span lang="en" dir="auto">Factor VII</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="IX因子" data-lang-code="en" data-lang-name="英语" data-foreign-title="Factor IX"><span class="ilh-page"><a href="/w/index.php?title=IX%E5%9B%A0%E5%AD%90&action=edit&redlink=1" class="new" title="IX因子（页面不存在）">IX</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Factor_IX" class="extiw" title="en:Factor IX"><span lang="en" dir="auto">Factor IX</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="X因子" data-lang-code="en" data-lang-name="英语" data-foreign-title="Factor X"><span class="ilh-page"><a href="/w/index.php?title=X%E5%9B%A0%E5%AD%90&action=edit&redlink=1" class="new" title="X因子（页面不存在）">X</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Factor_X" class="extiw" title="en:Factor X"><span lang="en" dir="auto">Factor X</span></a></span>）</span></span>）</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"><a href="/wiki/%E9%A6%99%E8%B1%86%E7%B4%A0%E7%B1%BB%E8%8D%AF%E7%89%A9" title="香豆素类药物">香豆素类</a>（<span class="ilh-all" data-orig-title="醋硝香豆醇" data-lang-code="en" data-lang-name="英语" data-foreign-title="Acenocoumarol"><span class="ilh-page"><a href="/w/index.php?title=%E9%86%8B%E7%A1%9D%E9%A6%99%E8%B1%86%E9%86%87&action=edit&redlink=1" class="new" title="醋硝香豆醇（页面不存在）">醋硝香豆醇</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Acenocoumarol" class="extiw" title="en:Acenocoumarol"><span lang="en" dir="auto">Acenocoumarol</span></a></span>）</span></span>、<a href="/wiki/%E6%9D%80%E9%BC%A0%E8%BF%B7" title="杀鼠迷">杀鼠迷</a>、<a href="/wiki/%E5%8F%8C%E9%A6%99%E8%B1%86%E7%B4%A0" title="双香豆素">双香豆素</a>、<a href="/wiki/%E4%BA%8C%E7%BE%9F%E9%A6%99%E8%B1%86%E7%B4%A0%E4%B9%99%E9%85%B8%E4%B9%99%E9%85%AF" title="二羟香豆素乙酸乙酯">二羟香豆素乙酸乙酯</a>、<a href="/wiki/%E8%8B%AF%E4%B8%99%E7%BE%9F%E5%9F%BA%E9%A6%99%E8%B1%86%E7%B4%A0" title="苯丙羟基香豆素">苯丙羟基香豆素</a>、<a href="/wiki/%E5%8D%8E%E6%B3%95%E6%9E%97" title="华法林">华法林</a>） <p><a href="/wiki/1,3-%E8%8C%9A%E6%BB%A1%E4%BA%8C%E9%85%AE" title="1,3-茚满二酮">1,3-茚满二酮</a>衍生物（<a href="/wiki/%E6%B0%AF%E8%8C%9A%E4%BA%8C%E9%85%AE" title="氯茚二酮">氯茚二酮</a>、<a href="/wiki/%E6%95%8C%E9%BC%A0" title="敌鼠">敌鼠</a>、<a href="/wiki/%E8%8B%AF%E8%8C%9A%E4%BA%8C%E9%85%AE" title="苯茚二酮">苯茚二酮</a>、<a href="/wiki/%E8%8C%B4%E8%8C%9A%E4%BA%8C%E9%85%AE" title="茴茚二酮">茴茚二酮</a>） </p> 其他（<span class="ilh-all" data-orig-title="噻氯香豆素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Tioclomarol"><span class="ilh-page"><a href="/w/index.php?title=%E5%99%BB%E6%B0%AF%E9%A6%99%E8%B1%86%E7%B4%A0&action=edit&redlink=1" class="new" title="噻氯香豆素（页面不存在）">噻氯香豆素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Tioclomarol" class="extiw" title="en:Tioclomarol"><span lang="en" dir="auto">Tioclomarol</span></a></span>）</span></span>）</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><span class="ilh-all" data-orig-title="xa因子" data-lang-code="en" data-lang-name="英语" data-foreign-title="Factor Xa"><span class="ilh-page"><a href="/w/index.php?title=Xa%E5%9B%A0%E5%AD%90&action=edit&redlink=1" class="new" title="Xa因子（页面不存在）">xa因子</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Factor_Xa" class="extiw" title="en:Factor Xa"><span lang="en" dir="auto">Factor Xa</span></a></span>）</span></span>抑制剂<br />（部分抑制II）</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><a href="/wiki/%E8%82%9D%E7%B4%A0" title="肝素">肝素</a>组／<br /><a href="/wiki/%E7%B3%96%E8%83%BA%E8%81%9A%E7%B3%96" title="糖胺聚糖">糖胺聚糖</a>类／<br />（bind<span class="ilh-all" data-orig-title="抗凝血酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Antithrombin"><span class="ilh-page"><a href="/w/index.php?title=%E6%8A%97%E5%87%9D%E8%A1%80%E9%85%B6&action=edit&redlink=1" class="new" title="抗凝血酶（页面不存在）">抗凝血酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Antithrombin" class="extiw" title="en:Antithrombin"><span lang="en" dir="auto">Antithrombin</span></a></span>）</span></span>）</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"><a href="/wiki/%E8%82%9D%E7%B4%A0" title="肝素">低分子量肝素</a>（<span class="ilh-all" data-orig-title="贝米肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Bemiparin sodium"><span class="ilh-page"><a href="/w/index.php?title=%E8%B4%9D%E7%B1%B3%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="贝米肝素（页面不存在）">贝米肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Bemiparin_sodium" class="extiw" title="en:Bemiparin sodium"><span lang="en" dir="auto">Bemiparin sodium</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="舍托肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Certoparin sodium"><span class="ilh-page"><a href="/w/index.php?title=%E8%88%8D%E6%89%98%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="舍托肝素（页面不存在）">舍托肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Certoparin_sodium" class="extiw" title="en:Certoparin sodium"><span lang="en" dir="auto">Certoparin sodium</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="达肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Dalteparin sodium"><span class="ilh-page"><a href="/w/index.php?title=%E8%BE%BE%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="达肝素（页面不存在）">达肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Dalteparin_sodium" class="extiw" title="en:Dalteparin sodium"><span lang="en" dir="auto">Dalteparin sodium</span></a></span>）</span></span>、<a href="/wiki/%E4%BE%9D%E8%AF%BA%E8%82%9D%E7%B4%A0%E9%92%A0" title="依诺肝素钠">依诺肝素</a>、<span class="ilh-all" data-orig-title="那屈肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Nadroparin calcium"><span class="ilh-page"><a href="/w/index.php?title=%E9%82%A3%E5%B1%88%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="那屈肝素（页面不存在）">那屈肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Nadroparin_calcium" class="extiw" title="en:Nadroparin calcium"><span lang="en" dir="auto">Nadroparin calcium</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="帕肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Parnaparin sodium"><span class="ilh-page"><a href="/w/index.php?title=%E5%B8%95%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="帕肝素（页面不存在）">帕肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Parnaparin_sodium" class="extiw" title="en:Parnaparin sodium"><span lang="en" dir="auto">Parnaparin sodium</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="瑞肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Reviparin sodium"><span class="ilh-page"><a href="/w/index.php?title=%E7%91%9E%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="瑞肝素（页面不存在）">瑞肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Reviparin_sodium" class="extiw" title="en:Reviparin sodium"><span lang="en" dir="auto">Reviparin sodium</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="亭扎肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Tinzaparin sodium"><span class="ilh-page"><a href="/w/index.php?title=%E4%BA%AD%E6%89%8E%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="亭扎肝素（页面不存在）">亭扎肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Tinzaparin_sodium" class="extiw" title="en:Tinzaparin sodium"><span lang="en" dir="auto">Tinzaparin sodium</span></a></span>）</span></span>） <p><a href="/wiki/%E4%BD%8E%E8%81%9A%E6%9C%A8%E7%B3%96" title="低聚木糖">低聚木糖</a>（<a href="/wiki/%E7%A3%BA%E8%BE%BE%E8%82%9D%E7%99%B8%E9%92%A0" title="磺达肝癸钠">磺达肝癸钠</a>、<span class="ilh-all" data-orig-title="艾卓肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Idraparinux"><span class="ilh-page"><a href="/w/index.php?title=%E8%89%BE%E5%8D%93%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="艾卓肝素（页面不存在）">艾卓肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Idraparinux" class="extiw" title="en:Idraparinux"><span lang="en" dir="auto">Idraparinux</span></a></span>）</span></span>） </p> <span class="ilh-all" data-orig-title="类肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Direct Xa inhibitor"><span class="ilh-page"><a href="/w/index.php?title=%E7%B1%BB%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="类肝素（页面不存在）">类肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Direct_Xa_inhibitor" class="extiw" title="en:Direct Xa inhibitor"><span lang="en" dir="auto">Direct Xa inhibitor</span></a></span>）</span></span>（<span class="ilh-all" data-orig-title="达那肝素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Danaparoid"><span class="ilh-page"><a href="/w/index.php?title=%E8%BE%BE%E9%82%A3%E8%82%9D%E7%B4%A0&action=edit&redlink=1" class="new" title="达那肝素（页面不存在）">达那肝素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Danaparoid" class="extiw" title="en:Danaparoid"><span lang="en" dir="auto">Danaparoid</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="舒洛地特" data-lang-code="en" data-lang-name="英语" data-foreign-title="Dermatan sulfate"><span class="ilh-page"><a href="/w/index.php?title=%E8%88%92%E6%B4%9B%E5%9C%B0%E7%89%B9&action=edit&redlink=1" class="new" title="舒洛地特（页面不存在）">舒洛地特</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Dermatan_sulfate" class="extiw" title="en:Dermatan sulfate"><span lang="en" dir="auto">Dermatan sulfate</span></a></span>）</span></span>、<span class="ilh-all" data-orig-title="硫酸皮肤素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Sulodexide"><span class="ilh-page"><a href="/w/index.php?title=%E7%A1%AB%E9%85%B8%E7%9A%AE%E8%82%A4%E7%B4%A0&action=edit&redlink=1" class="new" title="硫酸皮肤素（页面不存在）">硫酸皮肤素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Sulodexide" class="extiw" title="en:Sulodexide"><span lang="en" dir="auto">Sulodexide</span></a></span>）</span></span>）</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><span class="ilh-all" data-orig-title="Xa因子直接抑制剂" data-lang-code="en" data-lang-name="英语" data-foreign-title="Direct Xa inhibitor"><span class="ilh-page"><a href="/w/index.php?title=Xa%E5%9B%A0%E5%AD%90%E7%9B%B4%E6%8E%A5%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="Xa因子直接抑制剂（页面不存在）">Xa因子直接抑制剂</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Direct_Xa_inhibitor" class="extiw" title="en:Direct Xa inhibitor"><span lang="en" dir="auto">Direct Xa inhibitor</span></a></span>）</span></span><br />（xabans）</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E9%98%BF%E5%93%8C%E6%B2%99%E7%8F%AD" title="阿哌沙班">阿哌沙班</a></li> <li><span class="ilh-all" data-orig-title="贝曲西班" data-lang-code="en" data-lang-name="英语" data-foreign-title="Betrixaban"><span class="ilh-page"><a href="/w/index.php?title=%E8%B4%9D%E6%9B%B2%E8%A5%BF%E7%8F%AD&action=edit&redlink=1" class="new" title="贝曲西班（页面不存在）">贝曲西班</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Betrixaban" class="extiw" title="en:Betrixaban"><span lang="en" dir="auto">Betrixaban</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="依杜沙班" data-lang-code="en" data-lang-name="英语" data-foreign-title="Edoxaban"><span class="ilh-page"><a href="/w/index.php?title=%E4%BE%9D%E6%9D%9C%E6%B2%99%E7%8F%AD&action=edit&redlink=1" class="new" title="依杜沙班（页面不存在）">依杜沙班</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Edoxaban" class="extiw" title="en:Edoxaban"><span lang="en" dir="auto">Edoxaban</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="奥米沙班" data-lang-code="en" data-lang-name="英语" data-foreign-title="Otamixaban"><span class="ilh-page"><a href="/w/index.php?title=%E5%A5%A5%E7%B1%B3%E6%B2%99%E7%8F%AD&action=edit&redlink=1" class="new" title="奥米沙班（页面不存在）">奥米沙班</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Otamixaban" class="extiw" title="en:Otamixaban"><span lang="en" dir="auto">Otamixaban</span></a></span>）</span></span></li> <li><a href="/wiki/%E5%88%A9%E4%BC%90%E6%B2%99%E7%8F%AD" title="利伐沙班">利伐沙班</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose"><span class="ilh-all" data-orig-title="直接凝血酶抑制剂" data-lang-code="en" data-lang-name="英语" data-foreign-title="Direct thrombin inhibitor"><span class="ilh-page"><a href="/w/index.php?title=%E7%9B%B4%E6%8E%A5%E5%87%9D%E8%A1%80%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="直接凝血酶抑制剂（页面不存在）">直接凝血酶抑制剂</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Direct_thrombin_inhibitor" class="extiw" title="en:Direct thrombin inhibitor"><span lang="en" dir="auto">Direct thrombin inhibitor</span></a></span>）</span></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em">二价：<a href="/wiki/%E6%B0%B4%E8%9B%AD%E7%B4%A0" title="水蛭素">水蛭素</a>（<span class="ilh-all" data-orig-title="比伐卢定" data-lang-code="en" data-lang-name="英语" data-foreign-title="Bivalirudin"><span class="ilh-page"><a href="/w/index.php?title=%E6%AF%94%E4%BC%90%E5%8D%A2%E5%AE%9A&action=edit&redlink=1" class="new" title="比伐卢定（页面不存在）">比伐卢定</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Bivalirudin" class="extiw" title="en:Bivalirudin"><span lang="en" dir="auto">Bivalirudin</span></a></span>）</span></span>、<a href="/wiki/%E6%B0%B4%E8%9B%AD%E7%B4%A0" title="水蛭素">地西卢定</a>、<span class="ilh-all" data-orig-title="来匹卢定" data-lang-code="en" data-lang-name="英语" data-foreign-title="Lepirudin"><span class="ilh-page"><a href="/w/index.php?title=%E6%9D%A5%E5%8C%B9%E5%8D%A2%E5%AE%9A&action=edit&redlink=1" class="new" title="来匹卢定（页面不存在）">来匹卢定</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Lepirudin" class="extiw" title="en:Lepirudin"><span lang="en" dir="auto">Lepirudin</span></a></span>）</span></span>、<a href="/wiki/%E6%B0%B4%E8%9B%AD%E7%B4%A0" title="水蛭素">水蛭素</a>） <ul><li>单价：<span class="ilh-all" data-orig-title="阿加曲班" data-lang-code="en" data-lang-name="英语" data-foreign-title="Argatroban"><span class="ilh-page"><a href="/w/index.php?title=%E9%98%BF%E5%8A%A0%E6%9B%B2%E7%8F%AD&action=edit&redlink=1" class="new" title="阿加曲班（页面不存在）">阿加曲班</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Argatroban" class="extiw" title="en:Argatroban"><span lang="en" dir="auto">Argatroban</span></a></span>）</span></span></li> <li><a href="/wiki/%E9%81%94%E6%AF%94%E5%8A%A0%E7%BE%A4" title="達比加群">達比加群</a></li> <li><span class="ilh-all" data-orig-title="美拉加群" data-lang-code="en" data-lang-name="英语" data-foreign-title="Melagatran"><span class="ilh-page"><a href="/w/index.php?title=%E7%BE%8E%E6%8B%89%E5%8A%A0%E7%BE%A4&action=edit&redlink=1" class="new" title="美拉加群（页面不存在）">美拉加群</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Melagatran" class="extiw" title="en:Melagatran"><span lang="en" dir="auto">Melagatran</span></a></span>）</span></span><sup>‡</sup></li> <li><span class="ilh-all" data-orig-title="希美加群" data-lang-code="en" data-lang-name="英语" data-foreign-title="Melagatran"><span class="ilh-page"><a href="/w/index.php?title=%E5%B8%8C%E7%BE%8E%E5%8A%A0%E7%BE%A4&action=edit&redlink=1" class="new" title="希美加群（页面不存在）">希美加群</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Melagatran" class="extiw" title="en:Melagatran"><span lang="en" dir="auto">Melagatran</span></a></span>）</span></span><sup>‡</sup></li></ul></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: MistyRose">其他</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <li><span class="ilh-all" data-orig-title="REG1" data-lang-code="en" data-lang-name="英语" data-foreign-title="REG1"><span class="ilh-page"><a href="/w/index.php?title=REG1&action=edit&redlink=1" class="new" title="REG1（页面不存在）">REG1</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/REG1" class="extiw" title="en:REG1"><span lang="en" dir="auto">REG1</span></a></span>）</span></span></li> <li><a href="/wiki/%E9%98%BF%E8%B4%9D%E8%A5%BF%E5%8D%95%E6%8A%97" title="阿贝西单抗">阿贝西单抗</a></li> <li><span class="ilh-all" data-orig-title="去纤苷" data-lang-code="en" data-lang-name="英语" data-foreign-title="Defibrotide"><span class="ilh-page"><a href="/w/index.php?title=%E5%8E%BB%E7%BA%A4%E8%8B%B7&action=edit&redlink=1" class="new" title="去纤苷（页面不存在）">去纤苷</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Defibrotide" class="extiw" title="en:Defibrotide"><span lang="en" dir="auto">Defibrotide</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="雷马曲班" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ramatroban"><span class="ilh-page"><a href="/w/index.php?title=%E9%9B%B7%E9%A9%AC%E6%9B%B2%E7%8F%AD&action=edit&redlink=1" class="new" title="雷马曲班（页面不存在）">雷马曲班</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ramatroban" class="extiw" title="en:Ramatroban"><span lang="en" dir="auto">Ramatroban</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="抗凝血酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Antithrombin"><span class="ilh-page"><a href="/w/index.php?title=%E6%8A%97%E5%87%9D%E8%A1%80%E9%85%B6&action=edit&redlink=1" class="new" title="抗凝血酶（页面不存在）">抗凝血酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Antithrombin" class="extiw" title="en:Antithrombin"><span lang="en" dir="auto">Antithrombin</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="蛋白质C" data-lang-code="en" data-lang-name="英语" data-foreign-title="Protein C"><span class="ilh-page"><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8C&action=edit&redlink=1" class="new" title="蛋白质C（页面不存在）">蛋白质C</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Protein_C" class="extiw" title="en:Protein C"><span lang="en" dir="auto">Protein C</span></a></span>）</span></span>（<span class="ilh-all" data-orig-title="Drotrecogin alfa" data-lang-code="en" data-lang-name="英语" data-foreign-title="Drotrecogin alfa"><span class="ilh-page"><a href="/w/index.php?title=Drotrecogin_alfa&action=edit&redlink=1" class="new" title="Drotrecogin alfa（页面不存在）">Drotrecogin alfa</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Drotrecogin_alfa" class="extiw" title="en:Drotrecogin alfa"><span lang="en" dir="auto">Drotrecogin alfa</span></a></span>）</span></span>）</li> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:MistyRose;"><span class="ilh-all" data-orig-title="溶血栓药" data-lang-code="en" data-lang-name="英语" data-foreign-title="Thrombolytic drug"><span class="ilh-page"><a href="/w/index.php?title=%E6%BA%B6%E8%A1%80%E6%A0%93%E8%8D%AF&action=edit&redlink=1" class="new" title="溶血栓药（页面不存在）">溶血栓药</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Thrombolytic_drug" class="extiw" title="en:Thrombolytic drug"><span lang="en" dir="auto">Thrombolytic drug</span></a></span>）</span></span>类／<br /><span class="ilh-all" data-orig-title="溶纤维蛋白药" data-lang-code="en" data-lang-name="英语" data-foreign-title="fibrinolytic"><span class="ilh-page"><a href="/w/index.php?title=%E6%BA%B6%E7%BA%A4%E7%BB%B4%E8%9B%8B%E7%99%BD%E8%8D%AF&action=edit&redlink=1" class="new" title="溶纤维蛋白药（页面不存在）">溶纤维蛋白药</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/fibrinolytic" class="extiw" title="en:fibrinolytic"><span lang="en" dir="auto">fibrinolytic</span></a></span>）</span></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"><a href="/wiki/%E7%BA%A4%E7%BB%B4%E8%9B%8B%E7%99%BD%E6%BA%B6%E9%85%B6%E5%8E%9F%E6%BF%80%E6%B4%BB%E7%89%A9" title="纤维蛋白溶酶原激活物">纤维蛋白溶酶原激活物</a>类：<span class="ilh-all" data-orig-title="重组组织纤维溶酶原激活物" data-lang-code="en" data-lang-name="英语" data-foreign-title="Recombinant tissue plasminogen activators"><span class="ilh-page"><a href="/w/index.php?title=%E9%87%8D%E7%BB%84%E7%BB%84%E7%BB%87%E7%BA%A4%E7%BB%B4%E6%BA%B6%E9%85%B6%E5%8E%9F%E6%BF%80%E6%B4%BB%E7%89%A9&action=edit&redlink=1" class="new" title="重组组织纤维溶酶原激活物（页面不存在）">重组组织纤维溶酶原激活物</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Recombinant_tissue_plasminogen_activators" class="extiw" title="en:Recombinant tissue plasminogen activators"><span lang="en" dir="auto">Recombinant tissue plasminogen activators</span></a></span>）</span></span>（<a href="/wiki/%E9%98%BF%E6%9B%BF%E6%99%AE%E9%85%B6" title="阿替普酶">阿替普酶</a>、<span class="ilh-all" data-orig-title="瑞替普酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Reteplase"><span class="ilh-page"><a href="/w/index.php?title=%E7%91%9E%E6%9B%BF%E6%99%AE%E9%85%B6&action=edit&redlink=1" class="new" title="瑞替普酶（页面不存在）">瑞替普酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Reteplase" class="extiw" title="en:Reteplase"><span lang="en" dir="auto">Reteplase</span></a></span>）</span></span>、<a href="/wiki/%E6%9B%BF%E5%A5%88%E6%99%AE%E9%85%B6" title="替奈普酶">替奈普酶</a>） <ul><li>UPA（<a href="/wiki/%E5%B0%BF%E6%BF%80%E9%85%B6" title="尿激酶">尿激酶</a>、<span class="ilh-all" data-orig-title="沙芦普酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Saruplase"><span class="ilh-page"><a href="/w/index.php?title=%E6%B2%99%E8%8A%A6%E6%99%AE%E9%85%B6&action=edit&redlink=1" class="new" title="沙芦普酶（页面不存在）">沙芦普酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Saruplase" class="extiw" title="en:Saruplase"><span lang="en" dir="auto">Saruplase</span></a></span>）</span></span>）</li> <li><a href="/wiki/%E9%93%BE%E6%BF%80%E9%85%B6" title="链激酶">链激酶</a><sup>#</sup></li> <li><span class="ilh-all" data-orig-title="阿尼普酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Anistreplase"><span class="ilh-page"><a href="/w/index.php?title=%E9%98%BF%E5%B0%BC%E6%99%AE%E9%85%B6&action=edit&redlink=1" class="new" title="阿尼普酶（页面不存在）">阿尼普酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Anistreplase" class="extiw" title="en:Anistreplase"><span lang="en" dir="auto">Anistreplase</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="孟替普酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Monteplase"><span class="ilh-page"><a href="/w/index.php?title=%E5%AD%9F%E6%9B%BF%E6%99%AE%E9%85%B6&action=edit&redlink=1" class="new" title="孟替普酶（页面不存在）">孟替普酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Monteplase" class="extiw" title="en:Monteplase"><span lang="en" dir="auto">Monteplase</span></a></span>）</span></span></li> <li>其他<a href="/wiki/%E4%B8%9D%E6%B0%A8%E9%85%B8%E5%86%85%E8%82%BD%E9%85%B6" class="mw-redirect" title="丝氨酸内肽酶">丝氨酸内肽酶</a>：<span class="ilh-all" data-orig-title="安克洛酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ancrod"><span class="ilh-page"><a href="/w/index.php?title=%E5%AE%89%E5%85%8B%E6%B4%9B%E9%85%B6&action=edit&redlink=1" class="new" title="安克洛酶（页面不存在）">安克洛酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ancrod" class="extiw" title="en:Ancrod"><span lang="en" dir="auto">Ancrod</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="纤维蛋白酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Brinase"><span class="ilh-page"><a href="/w/index.php?title=%E7%BA%A4%E7%BB%B4%E8%9B%8B%E7%99%BD%E9%85%B6&action=edit&redlink=1" class="new" title="纤维蛋白酶（页面不存在）">纤维蛋白酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Brinase" class="extiw" title="en:Brinase"><span lang="en" dir="auto">Brinase</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="溶纤维蛋白酵素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Fibrinolysin"><span class="ilh-page"><a href="/w/index.php?title=%E6%BA%B6%E7%BA%A4%E7%BB%B4%E8%9B%8B%E7%99%BD%E9%85%B5%E7%B4%A0&action=edit&redlink=1" class="new" title="溶纤维蛋白酵素（页面不存在）">溶纤维蛋白酵素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Fibrinolysin" class="extiw" title="en:Fibrinolysin"><span lang="en" dir="auto">Fibrinolysin</span></a></span>）</span></span></li></ul></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:MistyRose;">非医用</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px;;;"><div style="padding:0em 0.25em"> <li><a href="/wiki/%E6%9F%A0%E6%AA%AC%E9%85%B8%E7%9B%90" class="mw-redirect" title="柠檬酸盐">柠檬酸盐</a></li> <li><a href="/wiki/%E4%B9%99%E4%BA%8C%E8%83%BA%E5%9B%9B%E4%B9%99%E9%85%B8" title="乙二胺四乙酸">乙二胺四乙酸</a></li> <li><a href="/wiki/%E8%8D%89%E9%85%B8%E7%9B%90" title="草酸盐">草酸盐</a></li> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background: transparent; padding: 0px;"><div><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/%E4%B8%96%E7%95%8C%E5%8D%AB%E7%94%9F%E7%BB%84%E7%BB%87%E5%9F%BA%E6%9C%AC%E8%8D%AF%E7%89%A9%E6%A0%87%E5%87%86%E6%B8%85%E5%8D%95" title="世界卫生组织基本药物标准清单">世卫基本药物（WHO-EM）</a></li> <li><sup>‡</sup>从市场<a href="/wiki/%E6%92%A4%E5%9B%9E%E8%8D%AF%E5%93%81%E5%88%97%E8%A1%A8" title="撤回药品列表">撤回</a></li> <li><sup>†</sup><a href="/wiki/%E8%87%A8%E5%BA%8A%E8%A9%A6%E9%A9%97" title="臨床試驗">臨床試驗</a><a href="/wiki/%E8%87%A8%E5%BA%8A%E8%A9%A6%E9%A9%97#Ⅲ期临床试验" title="臨床試驗">第三階段</a></li> <li><sup>§</sup>臨床試驗<a href="/wiki/%E8%87%A8%E5%BA%8A%E8%A9%A6%E9%A9%97#Ⅱ期临床试验" title="臨床試驗">未到第三階段</a></li></ul> </div></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Myeloid_navs" title="Template:Myeloid navs"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Myeloid_navs" title="Template talk:Myeloid navs"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:Myeloid_navs" title="Special:编辑页面/Template:Myeloid navs"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="骨髓來源細胞索引" style="font-size:110%;margin:0 5em"><a href="/wiki/%E9%AA%A8%E9%AB%93" title="骨髓">骨髓來源細胞</a>索引</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">描述</th><td class="navbox-list-with-group navbox-list navbox-_ODDEVEN_ hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="Template:Myeloid innate immune system" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Myeloid innate immune system"><span class="ilh-page"><a href="/w/index.php?title=Template:Myeloid_innate_immune_system&action=edit&redlink=1" class="new" title="Template:Myeloid innate immune system（页面不存在）">免疫系統</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Myeloid_innate_immune_system" class="extiw" title="en:Template:Myeloid innate immune system"><span lang="en" dir="auto">Template:Myeloid innate immune system</span></a></span>）</span></span></li> <li><a href="/wiki/Template:%E9%AB%93%E6%A0%B7%E8%A1%80%E7%BB%86%E8%83%9E%E4%B8%8E%E8%A1%80%E6%B5%86" title="Template:髓样血细胞与血浆">細胞</a></li> <li><a href="/wiki/Template:Blood_physiology" title="Template:Blood physiology">生理學</a> <ul><li><span class="ilh-all" data-orig-title="Template:Coagulation" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Coagulation"><span class="ilh-page"><a href="/w/index.php?title=Template:Coagulation&action=edit&redlink=1" class="new" title="Template:Coagulation（页面不存在）">凝結</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Coagulation" class="extiw" title="en:Template:Coagulation"><span lang="en" dir="auto">Template:Coagulation</span></a></span>）</span></span></li> <li><a href="/wiki/Template:%E8%A1%80%E7%BA%A2%E7%B4%A0%E8%9B%8B%E7%99%BD" title="Template:血红素蛋白">蛋白質</a></li> <li><a href="/wiki/Template:Granule_contents" title="Template:Granule contents">細粒內容物</a></li> <li><span class="ilh-all" data-orig-title="Template:Colony-stimulating factors" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Colony-stimulating factors"><span class="ilh-page"><a href="/w/index.php?title=Template:Colony-stimulating_factors&action=edit&redlink=1" class="new" title="Template:Colony-stimulating factors（页面不存在）">株落刺激</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Colony-stimulating_factors" class="extiw" title="en:Template:Colony-stimulating factors"><span lang="en" dir="auto">Template:Colony-stimulating factors</span></a></span>）</span></span></li> <li><a href="/wiki/%E8%A1%80%E5%9F%BA%E8%B3%AA" title="血基質">血基質</a>和<a href="/wiki/%E5%8D%9F%E5%95%89" title="卟啉">卟啉</a> <ul><li><a href="/wiki/Template:%E5%8D%9F%E5%95%89%E4%BB%A3%E8%B0%A2%E9%85%B6%E7%B1%BB" title="Template:卟啉代谢酶类">代謝酶</a></li> <li><a href="/wiki/Template:%E8%A1%80%E7%BA%A2%E7%B4%A0%E4%BB%A3%E8%B0%A2%E4%B8%AD%E9%97%B4%E4%BA%A7%E7%89%A9" title="Template:血红素代谢中间产物">中间产物</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">疾病</th><td class="navbox-list-with-group navbox-list navbox-_ODDEVEN_ hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:Hematology" title="Template:Hematology">紅血球</a></li> <li><span class="ilh-all" data-orig-title="Template:單核球和顆粒球疾病" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Monocyte and granulocyte disease"><span class="ilh-page"><a href="/w/index.php?title=Template:%E5%96%AE%E6%A0%B8%E7%90%83%E5%92%8C%E9%A1%86%E7%B2%92%E7%90%83%E7%96%BE%E7%97%85&action=edit&redlink=1" class="new" title="Template:單核球和顆粒球疾病（页面不存在）">單核球和顆粒球</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Monocyte_and_granulocyte_disease" class="extiw" title="en:Template:Monocyte and granulocyte disease"><span lang="en" dir="auto">Template:Monocyte and granulocyte disease</span></a></span>）</span></span></li> <li><a href="/wiki/Template:%E6%81%B6%E6%80%A7%E9%AB%93%E7%B3%BB%E8%82%BF%E7%98%A4" title="Template:恶性髓系肿瘤">腫瘤與癌症</a></li> <li><span class="ilh-all" data-orig-title="Template:Histiocytosis" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Histiocytosis"><span class="ilh-page"><a href="/w/index.php?title=Template:Histiocytosis&action=edit&redlink=1" class="new" title="Template:Histiocytosis（页面不存在）">組織細胞增多症</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Histiocytosis" class="extiw" title="en:Template:Histiocytosis"><span lang="en" dir="auto">Template:Histiocytosis</span></a></span>）</span></span></li> <li><a href="/wiki/Template:Cardiovascular_system_symptoms_and_signs" title="Template:Cardiovascular system symptoms and signs">症狀和體徵</a> <ul><li><span class="ilh-all" data-orig-title="Template:Eponymous medical signs for hematology" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Eponymous medical signs for hematology"><span class="ilh-page"><a href="/w/index.php?title=Template:Eponymous_medical_signs_for_hematology&action=edit&redlink=1" class="new" title="Template:Eponymous medical signs for hematology（页面不存在）">同名</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Eponymous_medical_signs_for_hematology" class="extiw" title="en:Template:Eponymous medical signs for hematology"><span lang="en" dir="auto">Template:Eponymous medical signs for hematology</span></a></span>）</span></span></li></ul></li> <li><a href="/wiki/Template:Myeloid_blood_tests" title="Template:Myeloid blood tests">驗血</a> <ul><li><a href="/wiki/Template:%E8%A1%80%E6%B6%B2%E4%B8%B4%E5%BA%8A%E4%B8%8E%E5%AE%9E%E9%AA%8C%E5%AE%A4%E5%BC%82%E5%B8%B8%E6%89%80%E8%A7%81" title="Template:血液临床与实验室异常所见">發現</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">治療</th><td class="navbox-list-with-group navbox-list navbox-_ODDEVEN_ hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:%E8%BC%B8%E8%A1%80%E9%86%AB%E5%AD%B8" title="Template:輸血醫學">輸血</a></li> <li>藥物 <ul><li><a href="/wiki/Template:%E6%8A%97%E8%A1%80%E6%A0%93%E8%8D%AF" title="Template:抗血栓药">血栓形成</a></li> <li><a href="/wiki/Template:%E6%8A%97%E5%87%BA%E8%A1%80%E8%8D%AF" title="Template:抗出血药">流血</a></li> <li><a href="/wiki/Template:%E5%85%B6%E4%BB%96%E8%A1%80%E6%B6%B2%E5%88%B6%E5%89%82" title="Template:其他血液制剂">其他</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">检索自“<a dir="ltr" href="https://zh.wikipedia.org/w/index.php?title=替格瑞洛&oldid=83904359">https://zh.wikipedia.org/w/index.php?title=替格瑞洛&oldid=83904359</a>”</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Special:%E9%A1%B5%E9%9D%A2%E5%88%86%E7%B1%BB" title="Special:页面分类">分类</a>：<ul><li><a href="/wiki/Category:%E6%8A%97%E8%A1%80%E5%B0%8F%E6%9D%BF%E8%8D%AF" title="Category:抗血小板药">抗血小板药</a></li><li><a href="/wiki/Category:CYP3A4%E6%8A%91%E5%88%B6%E5%89%82" title="Category:CYP3A4抑制剂">CYP3A4抑制剂</a></li><li><a href="/wiki/Category:%E6%B0%9F%E8%8B%AF" title="Category:氟苯">氟苯</a></li><li><a href="/wiki/Category:%E9%86%87" title="Category:醇">醇</a></li><li><a href="/wiki/Category:%E7%8E%AF%E4%B8%99%E5%9F%BA%E5%8C%96%E5%90%88%E7%89%A9" title="Category:环丙基化合物">环丙基化合物</a></li><li><a href="/wiki/Category:%E6%AD%A3%E4%B8%99%E5%9F%BA%E5%8C%96%E5%90%88%E7%89%A9" title="Category:正丙基化合物">正丙基化合物</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">隐藏分类：<ul><li><a href="/wiki/Category:%E4%BD%BF%E7%94%A8PMID%E9%AD%94%E6%9C%AF%E9%93%BE%E6%8E%A5%E7%9A%84%E9%A1%B5%E9%9D%A2" title="Category:使用PMID魔术链接的页面">使用PMID魔术链接的页面</a></li><li><a href="/wiki/Category:%E5%8C%85%E5%90%AB%E5%8C%BB%E5%AD%A6%E5%A3%B0%E6%98%8E%E7%9A%84%E6%9D%A1%E7%9B%AE" title="Category:包含医学声明的条目">包含医学声明的条目</a></li><li><a href="/wiki/Category:%E5%B8%A6%E6%9C%89%E9%9D%9E%E6%A0%87%E5%87%86%E5%AD%90%E9%A1%B5%E9%9D%A2%E7%9A%84Template:drugs.com%E9%93%BE%E6%8E%A5" title="Category:带有非标准子页面的Template:drugs.com链接">带有非标准子页面的Template:drugs.com链接</a></li><li><a href="/wiki/Category:%E7%84%A1CAS%E8%99%9F%E9%87%8D%E5%AE%9A%E5%90%91%E7%9A%84%E7%89%A9%E8%B3%AA%E6%A2%9D%E7%9B%AE" title="Category:無CAS號重定向的物質條目">無CAS號重定向的物質條目</a></li><li><a href="/wiki/Category:%E5%90%AB%E6%9C%89%E6%9C%AA%E6%A0%A1%E5%B0%8DCAS%E8%99%9F%E7%9A%84%E6%A2%9D%E7%9B%AE" title="Category:含有未校對CAS號的條目">含有未校對CAS號的條目</a></li><li><a href="/wiki/Category:%E5%85%B7%E6%9C%89ChemSpider%E5%8F%83%E6%95%B8%E7%9A%84%E8%97%A5%E7%89%A9%E6%A2%9D%E7%9B%AE" title="Category:具有ChemSpider參數的藥物條目">具有ChemSpider參數的藥物條目</a></li><li><a href="/wiki/Category:%E5%BE%9E%E7%B6%AD%E5%9F%BA%E6%95%B8%E6%93%9A%E7%8D%B2%E5%8F%96%E7%9A%84ECHA_InfoCard%E7%B7%A8%E7%A2%BC" title="Category:從維基數據獲取的ECHA InfoCard編碼">從維基數據獲取的ECHA InfoCard編碼</a></li><li><a href="/wiki/Category:Infobox-drug_molecular-weight_unexpected-character" title="Category:Infobox-drug molecular-weight unexpected-character">Infobox-drug molecular-weight unexpected-character</a></li><li><a href="/wiki/Category:%E5%8C%85%E5%90%ABInfobox_drug%E6%A8%A1%E6%9D%BF%E6%9D%A1%E7%9B%AE%E6%B2%A1%E6%9C%89%E7%BB%93%E6%9E%84%E5%9B%BE" title="Category:包含Infobox drug模板条目没有结构图">包含Infobox drug模板条目没有结构图</a></li><li><a href="/wiki/Category:%E6%B2%A1%E6%9C%89DrugBank%E8%AF%86%E5%88%AB%E7%A0%81%E7%9A%84%E5%8C%96%E5%AD%A6%E6%9D%A1%E7%9B%AE" title="Category:没有DrugBank识别码的化学条目">没有DrugBank识别码的化学条目</a></li><li><a href="/wiki/Category:%E6%B2%A1%E6%9C%89InChI%E6%9D%A5%E6%BA%90%E7%9A%84%E6%9D%A1%E7%9B%AE" title="Category:没有InChI来源的条目">没有InChI来源的条目</a></li><li><a href="/wiki/Category:%E6%B2%A1%E6%9C%89%E7%96%AB%E8%8B%97%E7%9B%AE%E6%A0%87%E7%9A%84%E5%8C%85%E5%90%ABInfobox_drug%E6%A8%A1%E6%9D%BF%E7%9A%84%E6%9D%A1%E7%9B%AE" title="Category:没有疫苗目标的包含Infobox drug模板的条目">没有疫苗目标的包含Infobox drug模板的条目</a></li><li><a href="/wiki/Category:%E5%AD%A4%E7%AB%8B%E7%9A%84%E5%AD%90%E5%AF%BC%E8%88%AA%E6%A1%86" title="Category:孤立的子导航框">孤立的子导航框</a></li><li><a href="/wiki/Category:%E4%BD%BF%E7%94%A8%E9%86%AB%E5%AD%B8%E5%B0%8E%E8%88%AA%E5%AD%90%E6%A8%A1%E6%9D%BF%E7%9A%84%E6%96%87%E7%AB%A0" title="Category:使用醫學導航子模板的文章">使用醫學導航子模板的文章</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> 本页面最后修订于2024年8月21日 (星期三) 13:04。</li> <li id="footer-info-copyright">本站的全部文字在<a rel="nofollow" class="external text" href="//creativecommons.org/licenses/by-sa/4.0/deed.zh">知识共享署名-相同方式共享 4.0协议</a>之条款下提供，附加条款亦可能应用。（请参阅<a class="external text" href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use">使用条款</a>）<br /> Wikipedia®和维基百科标志是<a rel="nofollow" class="external text" href="https://wikimediafoundation.org/zh">维基媒体基金会</a>的注册商标；维基™是维基媒体基金会的商标。<br /> 维基媒体基金会是按美国国內稅收法501(c)(3)登记的<a class="external text" href="https://donate.wikimedia.org/wiki/Special:MyLanguage/Tax_deductibility">非营利慈善机构</a>。<br /></li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">隐私政策</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:%E5%85%B3%E4%BA%8E">关于维基百科</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:%E5%85%8D%E8%B4%A3%E5%A3%B0%E6%98%8E">免责声明</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">行为准则</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">开发者</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/zh.wikipedia.org">统计</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Cookie声明</a></li> <li id="footer-places-mobileview"><a href="//zh.m.wikipedia.org/w/index.php?title=%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">手机版视图</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-f69cdc8f6-gxw57","wgBackendResponseTime":193,"wgPageParseReport":{"limitreport":{"cputime":"0.925","walltime":"1.178","ppvisitednodes":{"value":7667,"limit":1000000},"postexpandincludesize":{"value":303767,"limit":2097152},"templateargumentsize":{"value":7986,"limit":2097152},"expansiondepth":{"value":21,"limit":100},"expensivefunctioncount":{"value":81,"limit":500},"unstrip-depth":{"value":0,"limit":20},"unstrip-size":{"value":29450,"limit":5000000},"entityaccesscount":{"value":1,"limit":400},"timingprofile":["100.00% 929.232 1 -total"," 47.98% 445.801 1 Template:Drugbox"," 40.99% 380.854 1 Template:Infobox"," 37.32% 346.835 1 Template:Antithrombotics"," 36.73% 341.334 1 Template:NavboxV2"," 21.77% 202.326 82 Template:Le"," 10.98% 102.003 1 Template:Myeloid_navs"," 9.20% 85.464 1 Template:Navbox"," 7.24% 67.280 16 Template:Unbulleted_list"," 7.13% 66.235 1 Template:Reflist"]},"scribunto":{"limitreport-timeusage":{"value":"0.423","limit":"10.000"},"limitreport-memusage":{"value":5631585,"limit":52428800}},"cachereport":{"origin":"mw-api-int.codfw.main-849f99967d-dfhgl","timestamp":"20241124102313","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"\u66ff\u683c\u745e\u6d1b","url":"https:\/\/zh.wikipedia.org\/wiki\/%E6%9B%BF%E6%A0%BC%E7%91%9E%E6%B4%9B","sameAs":"http:\/\/www.wikidata.org\/entity\/Q420542","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q420542","author":{"@type":"Organization","name":"\u7ef4\u57fa\u5a92\u4f53\u9879\u76ee\u8d21\u732e\u8005"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2012-12-21T03:13:02Z","dateModified":"2024-08-21T13:04:50Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/0\/0f\/Ticagrelor.svg"}</script> </body> </html>