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Disponible en 22 idiomas" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-22" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">22 idiomas</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AA%D8%B5%D9%81%D9%8A%D8%A9_(%D8%B7%D8%A8)" title="تصفية (طب) (árabe)" lang="ar" hreflang="ar" data-title="تصفية (طب)" data-language-autonym="العربية" data-language-local-name="árabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Klirens_(farmakologija)" title="Klirens (farmakologija) (bosnio)" lang="bs" hreflang="bs" data-title="Klirens (farmakologija)" data-language-autonym="Bosanski" data-language-local-name="bosnio" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Clearance" title="Clearance (checo)" lang="cs" hreflang="cs" data-title="Clearance" data-language-autonym="Čeština" data-language-local-name="checo" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Clearance_(pharmacology)" title="Clearance (pharmacology) (inglés)" lang="en" hreflang="en" data-title="Clearance (pharmacology)" data-language-autonym="English" data-language-local-name="inglés" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D9%84%DB%8C%D8%B1%D8%A7%D9%86%D8%B3" title="کلیرانس (persa)" lang="fa" hreflang="fa" data-title="کلیرانس" data-language-autonym="فارسی" data-language-local-name="persa" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Puhdistuma" title="Puhdistuma (finés)" lang="fi" hreflang="fi" data-title="Puhdistuma" data-language-autonym="Suomi" data-language-local-name="finés" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Clairance_(biologie)" title="Clairance (biologie) (francés)" lang="fr" hreflang="fr" data-title="Clairance (biologie)" data-language-autonym="Français" data-language-local-name="francés" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Laju_ekskresi_renal" title="Laju ekskresi renal (indonesio)" lang="id" hreflang="id" data-title="Laju ekskresi renal" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonesio" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Clearance" title="Clearance (italiano)" lang="it" hreflang="it" data-title="Clearance" data-language-autonym="Italiano" data-language-local-name="italiano" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%AF%E3%83%AA%E3%82%A2%E3%83%A9%E3%83%B3%E3%82%B9_(%E8%96%AC%E7%90%86%E5%AD%A6)" title="クリアランス (薬理学) (japonés)" lang="ja" hreflang="ja" data-title="クリアランス (薬理学)" data-language-autonym="日本語" data-language-local-name="japonés" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%B2%AD%EC%86%8C%EC%9C%A8_(%EC%95%BD%EB%A6%AC%ED%95%99)" title="청소율 (약리학) (coreano)" lang="ko" hreflang="ko" data-title="청소율 (약리학)" data-language-autonym="한국어" data-language-local-name="coreano" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Klaring_(medisch)" title="Klaring (medisch) (neerlandés)" lang="nl" hreflang="nl" data-title="Klaring (medisch)" data-language-autonym="Nederlands" data-language-local-name="neerlandés" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Clearance" title="Clearance (noruego bokmal)" lang="nb" hreflang="nb" data-title="Clearance" data-language-autonym="Norsk bokmål" data-language-local-name="noruego bokmal" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Klirens" title="Klirens (polaco)" lang="pl" hreflang="pl" data-title="Klirens" data-language-autonym="Polski" data-language-local-name="polaco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Depura%C3%A7%C3%A3o_plasm%C3%A1tica" title="Depuração plasmática (portugués)" lang="pt" hreflang="pt" data-title="Depuração plasmática" data-language-autonym="Português" data-language-local-name="portugués" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Clearance_plasmatic" title="Clearance plasmatic (rumano)" lang="ro" hreflang="ro" data-title="Clearance plasmatic" data-language-autonym="Română" data-language-local-name="rumano" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9A%D0%BB%D0%B8%D1%80%D0%B5%D0%BD%D1%81_(%D0%BC%D0%B5%D0%B4%D0%B8%D1%86%D0%B8%D0%BD%D0%B0)" title="Клиренс (медицина) (ruso)" lang="ru" hreflang="ru" data-title="Клиренс (медицина)" data-language-autonym="Русский" data-language-local-name="ruso" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Klirens" title="Klirens (serbocroata)" lang="sh" hreflang="sh" data-title="Klirens" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbocroata" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Iz%C4%8Distek" title="Izčistek (esloveno)" lang="sl" hreflang="sl" data-title="Izčistek" data-language-autonym="Slovenščina" data-language-local-name="esloveno" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Klirens" title="Klirens (serbio)" lang="sr" hreflang="sr" data-title="Klirens" data-language-autonym="Српски / srpski" data-language-local-name="serbio" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Clearance" title="Clearance (sueco)" lang="sv" hreflang="sv" data-title="Clearance" data-language-autonym="Svenska" data-language-local-name="sueco" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a 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href="http://images.google.com/images?safe=off&as_rights=(cc_publicdomain%7ccc_attribute%7ccc_sharealike%7ccc_noncommercial%7ccc_nonderived)&q=%22Depuraci%C3%B3n+%28medicina%29%22">imágenes</a></span></span></span></div><div class="hide-when-compact"><small><div>Este aviso fue puesto el 15 de marzo de 2018.</div></small></div></td> </tr> </tbody></table> <p>En <a href="/wiki/Medicina" title="Medicina">medicina</a>, la <b>depuración</b>, <b>separación</b>, o <b>aclaramiento</b> (<b>CL</b>, del inglés <i>clearance</i>) de una sustancia es el inverso del <a href="/w/index.php?title=Tiempo_constante&action=edit&redlink=1" class="new" title="Tiempo constante (aún no redactado)">tiempo constante</a> que describe su índice de <a href="/wiki/Eliminaci%C3%B3n_(farmacolog%C3%ADa)" title="Eliminación (farmacología)">eliminación</a> del cuerpo dividido por su <a href="/wiki/Volumen_de_distribuci%C3%B3n" title="Volumen de distribución">volumen de distribución</a> (o total de <a href="/wiki/Agua_corporal" title="Agua corporal">agua corporal</a>).<sup id="cite_ref-1" class="reference separada"><a href="#cite_note-1"><span class="corchete-llamada">[</span>1<span class="corchete-llamada">]</span></a></sup><sup class="reference nowrap"><span title="Página: 228">: 228 </span></sup> </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Archivo:Physiology_of_Nephron_es.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Physiology_of_Nephron_es.svg/220px-Physiology_of_Nephron_es.svg.png" decoding="async" width="220" height="257" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Physiology_of_Nephron_es.svg/330px-Physiology_of_Nephron_es.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Physiology_of_Nephron_es.svg/440px-Physiology_of_Nephron_es.svg.png 2x" data-file-width="1073" data-file-height="1253" /></a><figcaption>Fisiología de la nefrona.</figcaption></figure> <p>El aclaramiento, puede determinarse de una forma global (<b>aclaramiento sistémico</b>) o de forma individualizada para cada vía (<b><a href="/wiki/Aclaramiento_hep%C3%A1tico" title="Aclaramiento hepático">aclaramiento hepático</a></b>, <b>renal</b>, etc.). La ecuación que recoge este concepto sería: </p> <center><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle CL_{o}=Q\cdot {\frac {(C_{A}-C_{V})}{C_{A}}}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <msub> <mi>L</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>o</mi> </mrow> </msub> <mo>=</mo> <mi>Q</mi> <mo>⋅</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mo stretchy="false">(</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> <mo>−</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>V</mi> </mrow> </msub> <mo stretchy="false">)</mo> </mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> </mfrac> </mrow> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle CL_{o}=Q\cdot {\frac {(C_{A}-C_{V})}{C_{A}}}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/77554cc17fcf60661e32b24c6f922f3e02795cf6" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.338ex; width:22.765ex; height:6.176ex;" alt="{\displaystyle CL_{o}=Q\cdot {\frac {(C_{A}-C_{V})}{C_{A}}}}"></span></center> <p>En donde <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle CL_{o}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <msub> <mi>L</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>o</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle CL_{o}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/a52068c3a8754a168fad0b6f4c012e82c82e7285" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:4.379ex; height:2.509ex;" alt="{\displaystyle CL_{o}}"></span> es el aclaramiento del órgano, <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle C_{A}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle C_{A}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/69c5f6fde0832b5aa24cc8d90aca913e132e9929" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:3.127ex; height:2.509ex;" alt="{\displaystyle C_{A}}"></span> la concentración plasmática en sangre arterial, <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle C_{V}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>V</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle C_{V}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/00c18988639f2937d3fe4dc00dfa0b0bd7e0bec1" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:3.158ex; height:2.509ex;" alt="{\displaystyle C_{V}}"></span> la concentración plasmática en sangre venosa y <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Q}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>Q</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle Q}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/8752c7023b4b3286800fe3238271bbca681219ed" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:1.838ex; height:2.509ex;" alt="{\displaystyle Q}"></span> el <a href="/wiki/Flujo_sangu%C3%ADneo" title="Flujo sanguíneo">flujo sanguíneo</a> del órgano. </p> <div class="mw-heading mw-heading2"><h2 id="Farmacología"><span id="Farmacolog.C3.ADa"></span>Farmacología</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Depuraci%C3%B3n_(medicina)&action=edit&section=1" title="Editar sección: Farmacología"><span>editar</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La <i>depuración</i> es un control usado en el área de <a href="/wiki/Farmacolog%C3%ADa" title="Farmacología">farmacología</a>, y se define como la capacidad que tiene un órgano para eliminar un <a href="/wiki/F%C3%A1rmaco" title="Fármaco">fármaco</a>. Se expresa mediante el número de mililitros de <a href="/wiki/Plasma_sangu%C3%ADneo" class="mw-redirect" title="Plasma sanguíneo">plasma</a> que se depura de una sustancia (<a href="/wiki/F%C3%A1rmaco" title="Fármaco">fármaco</a>) determinada por minuto. </p><p>La expulsión del fármaco puede ser consecuencia de procesos que tienen lugar en <a href="/wiki/Ri%C3%B1%C3%B3n" title="Riñón">riñones</a>, <a href="/wiki/H%C3%ADgado" title="Hígado">hígado</a> y otros órganos. </p><p>El <a href="/wiki/Aclaramiento_renal" title="Aclaramiento renal">aclaramiento renal</a> es usado también para evaluar algunos aspectos de la función renal. </p> <div class="mw-heading mw-heading2"><h2 id="Referencias">Referencias</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Depuraci%C3%B3n_(medicina)&action=edit&section=2" title="Editar sección: Referencias"><span>editar</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="listaref" style="list-style-type: decimal;"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><span id="CITAREFWright1972" class="citation libro">Wright, Samson (1972). <a rel="nofollow" class="external text" href="https://www.worldcat.org/oclc/396722036"><i>Samson Wright's applied physiology</i></a>. Cyril Arthur Keele, Neil Eric (12th edición). London: English Language Book Society, and Oxford University Press. <small><a href="/wiki/ISBN" title="ISBN">ISBN</a> <a href="/wiki/Especial:FuentesDeLibros/0-19-263321-X" title="Especial:FuentesDeLibros/0-19-263321-X">0-19-263321-X</a></small>. <small><a href="/wiki/OCLC" title="OCLC">OCLC</a> <a rel="nofollow" class="external text" href="//www.worldcat.org/oclc/396722036">396722036</a></small>.</span><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fes.wikipedia.org%3ADepuraci%C3%B3n+%28medicina%29&rft.au=Wright%2C+Samson&rft.aufirst=Samson&rft.aulast=Wright&rft.btitle=Samson+Wright%27s+applied+physiology&rft.date=1972&rft.edition=12th&rft.genre=book&rft.isbn=0-19-263321-X&rft.place=London&rft.pub=English+Language+Book+Society%2C+and+Oxford+University+Press&rft_id=https%3A%2F%2Fwww.worldcat.org%2Foclc%2F396722036&rft_id=info%3Aoclcnum%2F396722036&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div><style data-mw-deduplicate="TemplateStyles:r161257576">.mw-parser-output .mw-authority-control{margin-top:1.5em}.mw-parser-output .mw-authority-control .navbox table{margin:0}.mw-parser-output .mw-authority-control .navbox hr:last-child{display:none}.mw-parser-output .mw-authority-control .navbox+.mw-mf-linked-projects{display:none}.mw-parser-output .mw-authority-control .mw-mf-linked-projects{display:flex;padding:0.5em;border:1px solid var(--border-color-base,#a2a9b1);background-color:var(--background-color-neutral,#eaecf0);color:var(--color-base,#202122)}.mw-parser-output .mw-authority-control .mw-mf-linked-projects ul li{margin-bottom:0}.mw-parser-output .mw-authority-control .navbox{border:1px solid var(--border-color-base,#a2a9b1);background-color:var(--background-color-neutral-subtle,#f8f9fa)}.mw-parser-output .mw-authority-control .navbox-list{border-color:#f8f9fa}.mw-parser-output .mw-authority-control .navbox th{background-color:#eeeeff}html.skin-theme-clientpref-night .mw-parser-output .mw-authority-control .mw-mf-linked-projects{border:1px solid var(--border-color-base,#72777d);background-color:var(--background-color-neutral,#27292d);color:var(--color-base,#eaecf0)}html.skin-theme-clientpref-night .mw-parser-output .mw-authority-control .navbox{border:1px solid var(--border-color-base,#72777d)!important;background-color:var(--background-color-neutral-subtle,#202122)!important}html.skin-theme-clientpref-night .mw-parser-output .mw-authority-control .navbox-list{border-color:#202122!important}html.skin-theme-clientpref-night .mw-parser-output .mw-authority-control .navbox th{background-color:#27292d!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .mw-authority-control .mw-mf-linked-projects{border:1px solid var(--border-color-base,#72777d)!important;background-color:var(--background-color-neutral,#27292d)!important;color:var(--color-base,#eaecf0)!important}html.skin-theme-clientpref-os .mw-parser-output .mw-authority-control .navbox{border:1px solid var(--border-color-base,#72777d)!important;background-color:var(--background-color-neutral-subtle,#202122)!important}html.skin-theme-clientpref-os .mw-parser-output .mw-authority-control .navbox-list{border-color:#202122!important}html.skin-theme-clientpref-os .mw-parser-output .mw-authority-control .navbox th{background-color:#27292d!important}}</style><div class="mw-authority-control"><div role="navigation" class="navbox" aria-label="Navbox" style="width: inherit;padding:3px"><table class="hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width: 12%; 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