ElastoDB: Home

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <meta http-equiv="content-type" content="text/html; charset=iso-8859-1" /> <meta name="author" content="Trevis Alleyne" />  <meta name="description" content="ElastoDB. A comprehensive database of elastin gene and gene product sequences." /> <meta name="keywords" content="ElastoDB, elastin, tropoelastin, bioinformatics, computational biology, elastic, Parkinson Lab" /> <link rel="stylesheet" type="text/css" href="style.css" /> <link rel="Shortcut Icon" type="image/ico" href="./img/favicon3.ico" /> <script type="text/javascript" src="./jscript.js"></script> <title>ElastoDB: Home</title> </head> <body> <div id="centreBlock"> <div id="header"> <a href="./"><img src="/elastin/img/edb_logo3.gif" alt="ElastoDB logo" title="Return to ElastoDB home" /></a> </div> <div id="menu"> <hr /> <span> <a href="/elastin" accesskey="H" alt="Home">Home</a> | <a href="/elastin/search/search.php" accesskey="S" alt="Search" title="Search with the Sequence Browser">Search</a> | <a href="/elastin/contact.php" accesskey="C" alt="Contact Info">Contact</a> | <a href="/elastin/links.php" accesskey="L" alt="Links">Links</a> </span> <hr /> </div> <div id="rightBlock"> <br /> <a href="/"><img src="./img/lab_logo_white_small.jpg" alt="The Parkinson Lab" title="Parkinson Lab" /></a> <br /> <br /> <br /> <a href="http://www.sickkids.on.ca"><img src="./img/sickkidslogo.gif" alt="SickKids" title="SickKids" /></a> <br /> <br /> <br /> <br /> <br /> <br /> <img src="elasto.png" class="screen" alt="ElastoDB Sequence Browser Screenshot" title="Screenshot of the ElastoDB Sequence Browser" /> </div> <div id="content"> <h1>Welcome to ElastoDB!</h1> <h2>The Elastin Sequence Database</h2> <h3>What is elastin?</h3> <p>Elastin is a polymeric, extracellular protein responsible for providing elasticity to vertebrate tissues which are subjected to repeated cycles of stretching and mechanical manipulation. The constant mechanical stresses that these tissues undergo, coupled with the low turnover rate of elastin, means that elastin molecules need to be extremely resilient and highly durable. Indeed, the production or development of abnormal elastin may lead directly to genetic diseases such as supravalvular aortic stenosis (SVAS), cutis laxa, and elastoderma. <br /> <br /> It is clear that analysis of elastin sequences across multiple species will yield insights into the physical properties of these sequences along with knowledge about their evolution. However, until recently relatively few elastin sequences have been characterized despite the existence of several newly completed vertebrate genomes. For some lower vertebrates, no genomic or cDNA elastin sequences existed at all. <br /> <br /> </p> <h3>What is ElastoDB?</h3> <p>ElastoDB is a repository for well-characterized elastin sequences to facilitate its study. The database has since expanded to include other non-elastin sequences that share elastic properties.  <br /> <br /> To begin, click on <b>Search</b> from the menu bar to access the ElastoDB Sequence Browser. <br /> <br /> ElastoDB was developed at the The Parkinson Lab led by Dr. John Parkinson. It is hosted and supported by The Hospital for Sick Children, Toronto, Ontario, Canada. <br /> </p> <br /> </div> </div> </body> </html>

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ElastoDB: Home